Reproducibility and workflow efficiency of a novel software for quantitative coronary plaque characterization using photon-counting and energy-integrating detector computed tomography B. Sipos, B. Vattay, M. Boussoussou, M. Vecsey-Nagy, B. Nagy, A. Kubovje, P. Maurovich-Horvat, C. Schwemmer, V. Haase, M. Kiss, M. Schoebinger, B. Merkely, B. Szilveszter European Journal of Radiology, 2026 INTRODUCTION: The clinical adoption of quantitative coronary plaque characterization with coronary CT angiography (CCTA) is currently limited by time demands and lack of standardization across software platforms. This study aimed to evaluate the reproducibility and efficiency of a novel plaque quantification tool and to compare results between energy-integrating detector (EID-CT) and photon-counting detector (PCD)-CT. METHODS: In total, 170 patients were retrospectively enrolled in the current study: 86 patients were scanned using conventional EID-CT, while 84 using a dual-source PCD-CT. Quantitative plaque analysis was carried out using dedicated plaque analysis tools: syngo.CT Coronary Cockpit (Software 1, currently not commercially available) and MEDIS QAngioCT (Software 2) by three experienced readers. Total plaque volume (TPV) was quantified both automatically and manually. RESULTS: ). CONCLUSION: The prototype software offers a promising approach for rapid, reproducible quantification of coronary atherosclerosis, with PCD-CT technology further reducing manual corrections and inter-platform variability.
Assessing coronary in-stent restenosis using ultrahigh-resolution photon-counting detector CT: results from a two-center study Bálint Szilveszter, Muhammad Taha Hagar, Péter Kulyassa, Barbara Sipos, Anikó Kubovje, Borbála Vattay, Melinda Boussoussou, Sámuel Beke, Kristóf Nagy, Lili Száraz, Pál Maurovich-Horvat, Akos Varga-Szemes, Tilman Emrich, Milán Vecsey-Nagy European Journal of Radiology, 2026 INTRODUCTION: To assess the diagnostic accuracy of ultrahigh-resolution (UHR) photon-counting detector (PCD)-CT for detecting obstructive and non-obstructive coronary in-stent restenosis (ISR), using invasive coronary angiography (ICA) as the reference. METHODS: Consecutive patients with coronary stents who underwent clinically indicated coronary CT angiography (CCTA) on a dual-source PCD-CT were retrospectively identified from two academic centers. All UHR scans were reconstructed at 0.2 mm and 0.4 mm slice thickness, the latter served as an energy-integrating detector CT-like proxy. Series were assessed for the presence of non-obstructive (<50%) and obstructive (≥50%) ISR, with diagnostic accuracy validated against ICA in the overall cohort and in a sub-analysis of stents < 3 mm in diameter. RESULTS: Fifty patients (16.0% women; 70.9 ± 10.8 years) with 106 coronary stents were included. ICA identified 17 non-obstructive and 27 obstructive ISR. Non-obstructive ISR was detected in 10 stents on 0.2 mm UHR and 14 on 0.4 mm EID-like standard-resolution reconstructions.Obstructive ISR was described in 26 (0.2 mm) vs. 32 (0.4 mm) stents, respectively. The proportion of evaluable stents increased from 91.5% based on 0.4 mm to 99.1% with 0.2 mm UHR. Compared with standard-resolution images, 0.2-mm UHR improved non-obstructive ISR sensitivity (90.5%vs82.9%), specificity (100.0%vs78.5%), and accuracy (96.2%vs80.2%); and in obstructive ISR, specificity (98.7%vs82.3%), positive predictive value (96.3%vs64.1%), and accuracy (98.1%vs84.9%). Thin-slice UHR achieved higher accuracy in small-caliber stents (<3mm), for both non-obstructive (94.1vs73.5%) and obstructive ISR (94.1%vs79.4%). CONCLUSION: UHR PCD-CT demonstrated excellent diagnostic accuracy and significant improvements in ISR detection compared to the quasi-standard reconstructions, including non-obstructive and small-caliber stent ISR.
Comparative analysis of therapeutic strategies in atrial fibrillation patients with left atrial appendage thrombus despite optimal NOAC therapy Ferenc Komlósi, Bence Arnóth, Imre Szakál, Patrik Tóth, Henriette Mészáros, Helga Sánta, Gyula Bohus, Péter Vámosi, Elektra Bartha, Márton Horváth, Melinda Boussoussou, Nándor Szegedi, Zoltán Salló, István Osztheimer, Péter Perge, Gábor Széplaki, László Gellér, Béla Merkely, Klaudia Vivien Nagy Clinical Research in Cardiology, 2026 Background and aims Left atrial appendage (LAA) thrombus is the primary cause of stroke and systemic embolism in atrial fibrillation (AF). Non-vitamin-K oral anticoagulants (NOACs) effectively reduce LAA thrombus prevalence and stroke risk. However, the optimal treatment of a NOAC-resistant thrombus remains unclear. We aimed to evaluate therapeutic strategies for resolving LAA thrombus in patients on optimal NOAC therapy. Methods We retrospectively analyzed patients scheduled for cardioversion or catheter ablation of AF between 2014 and 2023 with LAA thrombus on transesophageal echocardiography (TEE) despite being on optimal NOAC therapy. We assessed how the applied management strategy affected thrombus resolution. Results Among the analyzed 120 patients, a change to a different NOAC occurred in 41% of cases, a transition to a VKA in 30%, and the supplementation with antiplatelet therapy in 11%. In contrast, 18% of the patients received unchanged therapy. Follow-up imaging at 65 [44 – 95] days showed successful thrombus resolution in 92 (77%) of cases, predicted by a lower CHA2DS2-VASc score (p = 0.01). Any modification of antithrombotic therapy was an independent predictor of thrombus resolution (OR 5.28 [1.55–18], p = 0.01). Of the four strategies, there was a trend toward better thrombus resolution with switching to a VKA (OR 3.23 [1.03–10.1], p = 0.04). Conclusion Resolution of LAA thrombus in patients already on adequate NOAC treatment may require a revision of the anticoagulation strategy. In addition, transitioning from NOAC to VKA might be considered. Graphical abstract
Comparative analysis of photon-counting and energy-integrating detector CT to identify obstructive coronary artery disease Melinda Boussoussou, Milán Vecsey-Nagy, Zsófia Jokkel, Borbála Vattay, Anikó Kubovje, Barbara Sipos, Márton Kolossváry, Anikó Ilona Nagy, Lili Száraz, Sámuel Beke, Bernard Schmidt, Máté Kiss, Béla Merkely, Josua A. Decker, Tilman Emrich, Akos Varga-Szemes, Pál Maurovich-Horvat, Bálint Szilveszter European Radiology, 2026 Objective To evaluate the patient-, vessel- and segment-based diagnostic performance of photon-counting detector CT (PCD-CT) compared to energy-integrating detector CT (EID-CT) for detecting ≥ 50% or ≥ 70% stenosis using invasive coronary angiography (ICA) as a reference standard. Materials and methods Patients with stable chest pain and ≥ 50% stenosis detected on dual source PCD-CT who subsequently underwent ICA were prospectively enroled. Diagnostic accuracy was calculated for PCD-CT vs ICA and additionally for a patient cohort scanned with EID-CT with similar risk profiles and disease prevalence. A Monte Carlo simulation based on diagnostic accuracy parameters was performed to estimate the potential reduction in ICA referrals. Results A total of 143 patients (66 ± 9 years, 27.3% female) with 572 vessels and 2431 segments were evaluated with PCD-CT and ICA. Regarding EID-CT, 109 patients (65 ± 9 years, 31.0% female), 436 vessels and 1853 segments were assessed, with every patient undergoing ICA. PCD-CT demonstrated significantly higher accuracy than EID-CT in detecting ≥ 50% stenosis: 88.1% vs 77.9% (patient level), 91.6% vs 77.8% (vessel level), and 97.7% vs 92.4% (segment level) ( p < 0.01 for all). For detecting ≥ 70% stenosis, PCD-CT also showed higher accuracy than EID-CT: 90.9% vs 70.6% (patient level), 94.6% vs 80.9% (vessel level), and 98.6% vs 94.1% (segment level) ( p < 0.01 for all). We demonstrated a potential mean reduction of 14.8% in ICA referrals when utilising PCD-CT compared to EID-CT. Conclusions PCD-CT provides improved per-patient, per-vessel and per-segment diagnostic performance in detecting obstructive CAD in symptomatic patients when compared to patients scanned on EID-CT. PCD-CT may lead to a significant decrease in ICA utilisation. Key Points Question Accurate coronary CT angiography guides treatment, but its diagnostic accuracy is limited by various factors . Findings Photon counting detector (PCD)-CT improved diagnostic performance in detecting ≥ 50% or ≥ 70% stenosis, potentially reducing unnecessary ICA referrals by 14.8% . Clinical relevance PCD-CT improves diagnostic accuracy over EID-CT and may reduce unnecessary ICA . Graphical Abstract
Oesophageal safety of high and very high power short duration pulmonary vein isolation: a randomized comparison of the 50 W and 90 W power settings—the HPSD oesophagus study Ferenc Komlósi, Klaudia Vivien Nagy, Péter Perge, Zoltán Salló, István Osztheimer, Edit Tanai, Patrik Tóth, Gábor Orbán, Arnold-Béla Ferencz, Márton Boga, István Hizoh, Veronika Papp, István Hritz, Attila Szijártó, Melinda Boussoussou, Béla Merkely, László Gellér, Nándor Szegedi European Heart Journal Open, 2026 Aims Point-by-point radiofrequency catheter ablation is commonly used for pulmonary vein isolation (PVI) in atrial fibrillation (AF). Very high power short duration (vHPSD) technology offers similar efficacy to high power short duration (HPSD) with reduced procedure times. A major complication of thermal ablation is atrio-oesophageal fistula (AEF), with oesophageal lesions and gastroparesis indicating increased risk. A direct comparison of HPSD and vHPSD regarding thermal safety is lacking. This randomized, single-centre study aimed to compare the thermal safety of vHPSD to HPSD and identify anatomical and biophysical predictors of thermal injury (ClinicalTrials.gov ID: NCT06617442). Methods and results Patients undergoing first-time PVI for AF were randomized to either HPSD (50 W) or vHPSD (90 W). The study followed a non-inferiority design, with the primary endpoint being a composite of oesophageal mucosal lesion and gastroparesis, assessed via endoscopy within 15 days post-procedure. Pre-procedural computed tomography scans were analysed for anatomical risk factors. Among 100 patients (50 per group), the primary endpoint occurred in 7 (14%) of the vHPSD group and 6 (12%) of the HPSD group (estimated mean difference −2%, lower bound of one-sided 95% CI −0.13), confirming non-inferiority. A smaller inter-lesion distance on the posterior wall was associated with increased risk (3.76 mm vs. 4.16 mm, P = 0.042). Conclusion Pulmonary vein isolation using 90 W (vHPSD) applications was non-inferior to the 50 W (HPSD) power setting in terms of oesophageal safety. A smaller inter-lesion distance on the posterior wall was predictive of oesophageal injury.
The impact of iterative reconstruction algorithms on dynamic computed tomography myocardial perfusion parameters Sarolta Borzsák, Borbála Vattay, Melinda Boussoussou, Milán Vecsey-Nagy, Márton Kolossváry, Ádám Levente Jermendy, Alexisz Panajotu, Dénes Juhász, Ferenc Imre Suhai, Béla Merkely, Bálint Szilveszter Imaging, 2026 Objectives Dynamic myocardial CT perfusion (CTP) enables the functional assessment of coronary artery disease. We aimed to assess the impact of iterative reconstruction using hybrid- (HIR) and model-based iterative reconstruction (IMR) – as compared to filtered back projection (FBP) on CTP-derived myocardial blood flow (MBF). Methods In our observational study we analyzed 35 patients who underwent dynamic myocardial CTP for the assessment of myocardial ischemia. Images were reconstructed using FBP, HIR and IMR algorithms. Qualitative and quantitative analysis of myocardial perfusion was performed by visual assessment and measurement of MBF on all reconstructed datasets. Image quality and interobserver variability were also assessed. Results Mean MBF was 105.61 ± 27.54 mL/100 g min −1 for FBP, 105.07 ± 27.72 mL/100 g min −1 for HIR and 103.69 ± 27.62 mL/100 g min −1 for IMR, without significant differences between the algorithms ( P = 0.49). Image noise was significantly lower using novel iterative reconstructions compared to FBP (mean SDaorta: 48.3 ± 19.7 for FBP, 30.4 ± 13.3 for HIR and 19.5 ± 5.9 for IMR, P < 0.001 for all). Intraclass correlation coefficient for MBF was 0.96, while kappa value was 0.45 for visual assessment. Conclusion Iterative reconstruction techniques reduce noise without altering MBF values of dynamic myocardial CTP. Therefore, further dose reduction may be achieved for dynamic myocardial CTP imaging.
Association of high-risk CT coronary artery plaque features with major adverse cardiovascular events: a prespecified secondary analysis of the DISCHARGE trial Bálint Szilveszter, Federico Biavati, Charlotte Sørum, Theodora Benedek, Patrick Donnelly, José F. Rodriguez-Palomares, Andrejs Erglis, Cyril Štěchovský, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Pal Maurovich-Horvat, Helena Domínguez Vall-Lamora, Imre Benedek, Clare Orr, Filipa Valente, Ligita Zvaigzne, Vojtěch Suchánek, Antanas Jankauskas, Filip Ađić, Michael Woinke, Niall Mulvihill, Iñigo Lecumberri, Erica Thwaite, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Donata Kuśmierz, Gudrun Maria Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Alberto Boi, Michael Fisher, Béla Merkely, Thomas Fritz Hansen, Rosca Aurelian, Stephanie Kelly, Bruno García del Blanco, Ainhoa Rubio, Melinda Boussoussou, Tem Jørgensen, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, Borbála Vattay, Roxana Hodas, Adriane Elisabeth Napp, Robert Haase, Sarah Feger, Mahmoud M. A. Mohamed, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Michelle C. Williams, Melanie Estrella, Maria Bosserdt, Peter Martus, Klaus F. Kofoed, Marc Dewey European Radiology, 2026 Objectives The prognostic role of high-risk plaque (HRP) features, including high coronary calcium scores detected by CT, beyond traditional cardiovascular risk factors and obstructive coronary artery disease (CAD), remains uncertain. This study evaluated the prognostic value of a combined HRP definition in stable chest pain patients with low-to-intermediate pretest probability of CAD. Materials and methods This prespecified analysis included participants randomized to the CT arm of the pragmatic, prospective 26-center European DISCHARGE trial (NCT02400229). The primary endpoint was major adverse cardiovascular events (MACE: cardiovascular death, nonfatal myocardial infarction, or stroke); the secondary endpoint was expanded MACE (transient ischemic attack and major procedure-related complications). Our combined HRP definition was any coronary plaque with positive remodeling, napkin-ring sign, low attenuation, or total calcium score ≥ 400 Agatston units. Results Among 1745 participants (age: 60 ± 10 years, 990 female), 35 MACE and 47 expanded MACE occurred at a median follow-up of 3.5 years (IQR: 2.9–4.2). After risk factor adjustment, the combined HRP definition was associated with a higher risk of MACE (HR: 3.81; 95% CI: 1.01–14.6; p = 0.050) and remained significantly associated with expanded MACE (HR: 0.21; 95% CI: 1.07–9.66; p = 0.038). Patients with both HRP and obstructive CAD conferred the highest MACE (HR: 8.78; 95% CI: 2.90–26.6; p < 0.001) and expanded MACE risk (HR: 7.31; 95% CI: 3.06–17.48; p < 0.001) compared with patients without HRP or obstructive CAD. HRP alone showed a prognostic impact comparable to obstructive CAD alone. Conclusion HRP features on coronary CT provide incremental predictive value for MACE, comparable to obstructive CAD, after adjusting for traditional cardiovascular risk factors in this large pan-European cohort. Trial registration ClinicalTrials.gov NCT02400229. Key Points Question Do high-risk plaque (HRP) features on coronary CT have incremental prognostic value after adjustment for cardiovascular risk factors in stable chest pain? Findings A combined definition of HRP features on coronary CT was independently associated with major adverse cardiovascular events, with similar prognostic value to obstructive coronary artery disease after risk adjustment. Clinical relevance HRP features, including a coronary artery calcium score ≥ 400 Agatston units or traditional high-risk plaque characteristics on coronary CT, provide incremental prognostic value in predicting MACE in stable chest pain patients, offering a potential tool for improved risk stratification and management. Graphical Abstract
Interaction Between Statin Use, Coronary Artery Disease Phenotypes, on Computed Tomography Angiography, and Cardiovascular Outcomes Bálint Szilveszter, Borbála Vattay, Melinda Boussoussou, Milán Nagy-Vecsey, György Rokszin, Ibolya Fábián, Judit Simon, Béla Merkely, Pál Maurovich-Horvat, Márton Kolossváry Jacc Cardiovascular Imaging, 2025 BACKGROUND: Although statins are recommended for decreasing cardiovascular risk, their efficacy across different patient phenotypes stratified by coronary artery disease (CAD) remains unclear. OBJECTIVES: This study aims to evaluate whether statins decrease major adverse cardiac events (MACE) among CAD phenotypes according to severity, vulnerability and extent categorized by coronary computed tomography angiography (CTA). METHODS: The authors analyzed consecutive patients who were referred for coronary CTA at a tertiary center for the assessment of chronic coronary syndrome. The primary endpoint was MACE defined as a composite of all-cause mortality, acute myocardial infarction, or revascularization for unstable angina. Statin use was defined as annualized days on statin therapy (days on statin based on redeemed prescriptions, divided by follow-up time), and analyzed for each 10% increase in statin use over the follow-up period. Interaction analysis, adjusting for risk factors was applied to define treatment benefit across CAD phenotypes. RESULTS: Overall, 11,026 individuals (mean age: 58.6 ± 11.9 years, 54.7% male) were analyzed who underwent coronary CTA between January 1, 2013, and December 31, 2020. A 10% increase in statin use was associated with lower risk for MACE the stratified Cox-regression model in patients with CAD (adjusted HR [aHR]: 0.95 [95% CI: 0.92-0.99]; P = 0.006), but not in patients without CAD (aHR: 0.95 [95% CI: 0.84-1.07]; P = 0.370). In the total population using interaction analysis including CAD phenotypes, a 10% increase in statin use decreased the risk for MACE in the presence of obstructive CAD (aHR: 0.91 [95% CI: 0.85-0.97]; P = 0.006), high-risk plaque (aHR: 0.82 [95% CI: 0.68-0.98]; P = 0.026), calcium score of ≥400 (aHR: 0.93 [95% CI: 0.87-0.99]; P = 0.024), and segment involvement score of >4 (aHR: 0.89 [95% CI: 0.84-0.95]; P < 0.001), but not for any CAD (aHR: 0.95 [95% CI: 0.85-1.07]; P = 0.411). CONCLUSIONS: Statin efficacy to decrease MACE depends on CAD phenotypes and increases with the extent and severity of disease and in the presence of high-risk plaques. Patients without CAD have no benefit from statin therapy regarding MACE. Coronary CTA may play a pivotal role in optimizing statin allocation for personalized treatment decisions to prevent MACE.
Prognostic and therapeutic implications of a low aortic valve calcium score in patients with low-gradient aortic stenosis D Juhász, M Vecsey-Nagy, Á L Jermendy, B Szilveszter, J Simon, B Vattay, M Boussoussou, D Dávid, P Maurovich-Horvát, B Merkely, A Apor, L Molnár, E Dósa, M Rakovics, J Johnson, A Manouras, A I Nagy European Heart Journal Cardiovascular Imaging, 2025 Aims Low-gradient (LG) aortic stenosis (AS) poses a diagnostic challenge. Aortic valve calcium score (AVCS) assessment has emerged as a complementary diagnostic method when echocardiography provides discordant results. However, the diagnostic and prognostic values of AVCS in LGAS have not been thoroughly studied. Our aims in this study were to investigate the prognostic importance of AVCS in LGAS and to assess whether symptomatic patients with LGAS and low AVCS may benefit from aortic valve intervention (AVI). Methods and results A total of 327 symptomatic patients (78.5 ± 7.3 years, 51% women) with severe AS defined by the aortic valve area who underwent computed tomography for transcatheter aortic valve intervention (TAVI) planning were enrolled. AVCS was measured. AVCS &lt; 2000AU in men and &lt; 1200 AU in women was considered a low AVCS. A total of 243 patients had high gradient (HG) and 84 had LGAS. A low AVCS was present in 25 (10%) patients with HG and 34 (40%) with LGAS. Over a median follow-up period of 4.9 years, 194 deaths occurred. In multivariate analysis, AVCS was a significant independent predictor of all-cause mortality among patients with HGAS [adjusted hazard ratio (aHR): 2.317; CI: 1.104–4.861; P = 0.026] but not among those with LGAS (aHR: 0.848; CI: 0.434–1.658; P = 0.630). After propensity score matching between patients who underwent AVI and those who were medically treated, AVI (94% TAVI) was a significant and independent predictor of survival among LGAS patients with a low AVCS even after adjustment for clinical variables (aHR: 0.102, CI: 0.028–0.369; P &lt; 0.001). Conclusion The prevalence of a low AVCS is much higher in patients with LGAS than in those with HGAS. In patients with symptomatic severe LGAS, a low AVCS does not entail a better prognosis. AVI is equally beneficial in LGAS patients with a high or low AVCS, similarly to those with HGAS.
Line Profile Edge-Width Half Maximum Analysis of Mixed Coronary Plaque Phantom by Photon Counting CT: Impact of Calcium and Iodine on Detection of Low Attenuation Plaque with Ground Truth Reference Bálint Szilveszter, Anikó Kubovje, Márton Kolossváry, Hugo Marques, Borbála Vattay, Zsófia Jokkel, Milán Vecsey-Nagy, Melinda Boussoussou, Shawn Newlander, George Wesbey, Elliot McVeigh Progress in Biomedical Optics and Imaging Proceedings of SPIE, 2025 The majority of acute myocardial infarcts (AMI) occur in non-calcified plaques with <50% stenosis. Low-attenuation plaque (LAP) is this most important compositional plaque feature predicting future development of AMI. A recent societal expert consensus statement concluded that accuracy and reproducibility of LAP quantitation by CT is poor. Photon counting CT (PCD-CT) has shown ultra-high resolution (UHR) acquisition mode reduces blooming and partial volume averaging (PVA) artifacts in comparison to standard resolution mode with helical full rotation CT angiography (CTA), however its impact on LAP detection is unknown. Therefore, we evaluated the impact of UHR on detection of LAP in a mixed coronary plaque (-60 HU pericardial fat, 1000 HU iodine lumen, 75 HU LAP, and 300 HU calcified plaque (CP)) with a clinical coronary CTA acquisition with simulated gating in comparison to ground truth. We show a profound impact of iodine and CP on LAP detection in both UHR and standard reconstructions. These limitations can provide a realistic foundation upon which to optimize PCD-CT CCTA protocols.
Health Status Outcomes After Computed Tomography or Invasive Coronary Angiography for Stable Chest Pain A Prespecified Secondary Analysis of the DISCHARGE Randomized Clinical Trial , Sebastian Flynn, Lucia Moore, Massimo Mancone, Nina Rieckmann, Konrad Neumann, Pál Maurovich-Horvat, Klaus F. Kofoed, Theodora Benedek, Maria Bosserdt, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Cyril Štěchovský, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Bela Merkely, Andreas D. Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtěch Suchánek, Laura Zajančkauskienė, Filip Ađić, Michael Woinke, Darragh Waters, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Lucia Ilaria Birtolo, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Gildo Matta, Michael Fisher, Bálint Szilveszter, Linnea Larsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Zsófia D. Drobni, Birgit Jurlander, Susan Regan, Hug Cuéllar Calabria, Melinda Boussoussou, Thomas Engstrøm, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud M. A. Mohamed, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Florian Michallek, Daniel B. Mark, Peter Martus, Jonathan D. Dodd, Harold C. Sox, Lina M. Serna-Higuita, Marc Dewey JAMA Cardiology, 2025
Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial Massimo Mancone, Aldo J. Vázquez Mézquita, Lucia Ilaria Birtolo, Pal Maurovich-Horvat, Klaus F. Kofoed, Theodora Benedek, Patrick Donnelly, Jose Rodriguez-Palomares, Andrejs Erglis, Cyril Štěchovský, Gintare Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhanni Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jaqueline Müller-Nordhorn, Bela Merkely, Per E. Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtěch Suchánek, Antanas Jankauskas, Filip Ađić, Michael Woinke, Stephen Keane, Ignacio Lecumberri, Erica Thwaite, Mariusz Kruk, Vladimir Jovanovic, Donata Kuśmierz, Gudren Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Vitanio Palmisano, Michael Fisher, Zsófia D. Drobni, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Melinda Boussoussou, Jens D. Hove, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, Dávid Becker, Linnea Larsen, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Pamela S. Douglas, Melanie Estrella, Maria Bosserdt, Peter Martus, Lina M. Serna-Higuita, Jonathan D. Dodd, Marc Dewey European Radiology, 2024
Erratum. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease. Diabetes Care 2023;46:2015–2023 Theodora Benedek, Viktoria Wieske, Bálint Szilveszter, Klaus F. Kofoed, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Josef Veselka, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Bela Merkely, Per E. Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Martin Horváth, Antanas Jankauskas, Filip Ađić, Michael Woinke, Niall Mulvihill, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Milica Stefanovic, Massimo Mancone, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Marco Melis, Michael Fisher, Melinda Boussoussou, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Mihály Károlyi, Jens D. Hove, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, László Gellér, Linnea Larsen, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, John Danesh, Melanie Estrella, Maria Bosserdt, Peter Martus, Jonathan D. Dodd, Marc Dewey Diabetes Care, 2024
Age and Computed Tomography and Invasive Coronary Angiography in Stable Chest Pain: A Prespecified Secondary Analysis of the DISCHARGE Randomized Clinical Trial , Maria Bosserdt, Lina M. Serna-Higuita, Gudrun Feuchtner, Bela Merkely, Klaus F. Kofoed, Theodora Benedek, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Cyril Štěchovský, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Bálint Szilveszter, Per E. Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtěch Suchánek, Antanas Jankauskas, Filip Ađić, Michael Woinke, Mark Hensey, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Donata Kuśmierz, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Maurizio Porcu, Michael Fisher, Melinda Boussoussou, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Pál Maurovich-Horvat, Jens D. Hove, Ioana Rodean, Susan Regan, Hug Cuellar-Calabria, Levente Molnár, Linnea Larsen, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Harold C. Sox, Marc Dewey JAMA Cardiology, 2024
Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain Federico Biavati, Luca Saba, Melinda Boussoussou, Klaus F. Kofoed, Theodora Benedek, Patrick Donnelly, José Rodríguez-Palomares, Andrejs Erglis, Cyril Štěchovský, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Pál Maurovich-Horvat, Per E. Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtěch Suchánek, Antanas Jankauskas, Filip Ađić, Michael Woinke, Diarmaid Cadogan, Iñigo Lecumberri, Erica Thwaite, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Riccardo Cau, Michael Fisher, Bela Merkely, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno García del Blanco, Ainhoa Rubio, Bálint Szilveszter, Jens D. Hove, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, István Ferenc Édes, Linnea Larsen, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Matthew J. Budoff, Melanie Estrella, Peter Martus, Maria Bosserdt, Marc Dewey, and Radiology, 2024
Computed tomography versus invasive coronary angiography in patients with diabetes and suspected coronary artery disease Theodora Benedek, Viktoria Wieske, Bálint Szilveszter, Klaus F. Kofoed, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Josef Veselka, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Bela Merkely, Per E. Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Martin Horváth, Antanas Jankauskas, Filip Ađić, Michael Woinke, Niall Mulvihill, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Milica Stefanovic, Massimo Mancone, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Marco Melis, Michael Fisher, Melinda Boussoussou, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Mihály Károlyi, Jens D. Hove, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, László Gellér, Linnea Larsen, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, John Danesh, Melanie Estrella, Maria Bosserdt, Peter Martus, Jonathan D. Dodd, Marc Dewey Diabetes Care, 2023
CT or Invasive Coronary Angiography in Stable Chest Pain , Pál Maurovich-Horvat, Maria Bosserdt, Klaus F. Kofoed, Nina Rieckmann, Theodora Benedek, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Cyril Štěchovský, Gintare Šakalyte, Nada Čemerlić Adić, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Iñaki Gutierrez-Ibarluzea, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Bela Merkely, Andreas D. Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtěch Suchánek, Laura Zajančkauskiene, Filip Adić, Michael Woinke, Mark Hensey, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Gildo Matta, Michael Fisher, Bálint Szilveszter, Linnea Larsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Zsófia D. Drobni, Birgit Jurlander, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, Melinda Boussoussou, Thomas Engstrøm, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Marc Dewey New England Journal of Medicine, 2022
THE GLOBAL THREAT OF CLIMATE CHANGE: IMPLICATIONS ON CARDIOVASCULAR DISEASES AND THE LATEST KNOWLEDGE CONCERNING PREVENTIVE MEDICINE Encyclopedia of Climate Change Volume 11 11 Volume Set, 2020
