Meidita Kemala Sari

@umri.ac.id

Jurusan Kimia/ Fakultas Matematika Ilmu Pengetahuan Alam dan Kesehatan
Universitas Muhammadiyah Riau

Meidita Kemala Sari


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https://researchid.co/meiditaks_97

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Inorganic Chemistry, Colloid and Surface Chemistry
4

Scopus Publications

40

Scholar Citations

4

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Synthesis, Antimalarial Activities of Secondary Amine-Substituted Eugenol Compounds against Plasmodium falciparum and in silico Molecular Docking Analysis
    Jufrizal Syahri, Rahmiwati Hilma, Nurlaili Nurlaili, Meidita Kemala Sari, Neni Frimayanti, Amatul Hamizah Ali, Jalifah Latip
    Sains Malaysiana, 2023
    Multi-resistance cases with antimalarial drugs had been developed in over the years. One of the ways of developing antimalarial drugs is to focus on searching for the potential antifolate inhibitors against Plasmodium sp. from synthetic or natural products. The aims of this research was to synthesis secondary amine-substituted eugenol compounds through the Mannich reaction for antimalarial evaluation using Plasmodium falciparum 3D7. The compounds were also evaluated on Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) as a protein target and the compounds’ drug-likeness properties were determined. Five secondary amine-substituted eugenol compounds (1a-e) were synthesized via substitution of the secondary amine i.e., pyrrolidine, piperidine, methyl piperidine, and morpholine in the eugenol structures. The plasmodium lactate dehydrogenase assay (pLDH) showed that 1a and 1c had good antimalarial effects against P. falciparum 3D7 with the IC50s values of 0.89 mM and 0.62 mM, respectively. The molecular docking analysis showed that 1a and 1c had perfect interaction with PfDHFR-TS (PDB ID: 1J3I) with strong hydrogen bond interactions occurring with PfDHFR-TS protein. The eugenol derivatives 1a and 1c exerted CDOCKER binding energies of -6.1407 and -6.6536 kcal/mol, respectively. Based on this research, it was found that PfDHFR-TS is a plausible protein target for the synthesized secondary amine-substituted eugenol in P. falciparum infection. The substitution of a secondary amine group for eugenol significantly enhanced the antimalarial properties of the compounds. Thus, eugenol derivatives are potential compounds to be pursued to combat folate resistance in malarial infection.
  • Adsorption of Pb(II) from Aqueous Solutions onto Humic Acid Modified by Urea-Formaldehyde: Effect of pH, Ionic Strength, Contact Time, and Initial Concentration
    Meidita Kemala Sari, Rahmat Basuki, Bambang Rusdiarso
    Indonesian Journal of Chemistry, 2021
    Humic acid (HA) and urea-formaldehyde (UF) have been frequently reported as heavy metal adsorbents. However, the literature has never written HA modification by UF to improve the adsorbent’s performance. In this study, a new adsorbent of humic acid-urea formaldehyde (HA-UF) was synthesized. The reaction of the conducted the formation of HA-UF –COOH group of HA with the –NH2 group of UF was evidenced by decreasing total acidity from 549.26 cmol/kg (in HA) to 349.30 cmol/kg (in HA-UF). The success of HA-UF formation was characterized by attenuated total reflection-infrared (ATR-IR), energy dispersive X-Ray (EDX), and X-ray diffraction (XRD). The high stability of HA-UF was shown by 96.8% remaining in solid form at pH 12.4. Adsorption behavior of Pb(II) onto HA-UF was influenced by the ionic strength and pH, which were mainly driven by the ion exchange mechanism (EDR = 9.75 kJ/mol). The higher ionic strength will affect decreasing adsorbed Pb(II) at the optimum pH of 5.5. The effect of initial Pb(II) concentration (isotherm) shows that the data fitted well with the Langmuir-b isotherm model indicated the monolayer adsorption of Pb(II) onto homogenous surfaces of the HA-UF with the adsorption capacity of 2.26 × 10–4 mol/g (which is higher than its original HA of 1.12 × 10–4 mol/g). The Ho (pseudo-second-order) kinetics model represented the effect of contact time (kinetics) was represented by the Ho kinetics model. The synthesized adsorbent is also reusable, with 88.59% of adsorption capacity remaining in the fifth recycle run. Therefore, the adsorbent of HA-UF is suggested to be a promising candidate for adsorption applications.
  • Synthesis and characterization of composite of Al2O3/activated carbon by hydrothermal method
    Allwar Allwar, Meidita Kemala Sari, Feby Rahmawati, Afra Najiyah Amatullah
    Key Engineering Materials, 2019
    Composite of Al2O3/activated carbon (Al2O3/AC) has been successfully synthesized by hydrothermal method. It was synthesized from activated carbon from oil palm shell waste by mixing with Al2O3 powder in ethanol. The mixer was placed in a hydrothermal reactor and heated up to 250°C for 3 hours. Comparison study of surface area between activated carbon and composite of Al2O3/AC indicate that surface area decreased from 67.6 to 65.3 m2/g. However, XRD analysis shows that there was a slight different hkl phase. Characterization using FTIR showed that the composite have more oxygen functional groups compared with activated carbon. SEM-EDX of composite of Al2O3/AC showed an increasing of crystalline structure on the surface.
  • Synthesis and characterization of composite of Al2O3/activated carbon from palm oil shell by hydrothermal method
    Allwar Allwar, Meidita Kemala Sari
    Aip Conference Proceedings, 2018
    Composite of Al2O3/activated carbon (Al2O3/AC) has been successfully synthesized by hydrothermal method. Composite of Al2O3/AC was synthesized from activated carbon by mixing with Al2O3 powder in liquid phase using ethanol and treated with hydrothermal at a temperature of 250°C for 3 hours. Comparison study of surface area between activated carbon and composite of Al2O3/AC indicate that surface area increase from 63.6 to 67.87 m2/g. However, XRD analysis shows that there is slight different hkl phase. Characterization using FTIR show that the composite have more oxygen functional groups compared with activated carbon.

RECENT SCHOLAR PUBLICATIONS

  • Pemantauan Kandungan Logam pada Pupuk dan Limbah Palm Oil Mill Effluent (POME) di Riau menggunakan Atomic Absorbtion Spectroscopy (AAS) dalam Mendukung Tujuan Pembangunan …
    MK Sari
    Proceedings National Conference Sinesia 2 (1), 299-317 , 2026
    2026.0
  • Pemantauan Logam pada Pupuk dan POME menggunakan AAS untuk Industri Sawit Berkelanjutan di Riau
    MK Sari, SH Siregar, D David, MW Nugraha, AA Manurung
    National Conference Sinesia III | Tut Wuri Handayani 3 (2), 299-317 , 2026
    2026.0
  • Pemanfaatan Asam humat dari Gambut Degradasi Riau untuk Adsorpsi Logam Berat Berkelanjutan
    MK Sari, B Rusdiarso, DR Eliana, SH Siregar
    National Conference Sinesia III | Tut Wuri Handayani 3 (2), 281-298 , 2026
    2026.0
  • Penguatan Kesadaran Digital Masyarakat terhadap Ancaman Siber dan Judi Online melalui Program KKN MAs
    MK Sari, M Tauhid, MNI Hasbi, E Alkautsar, N Aditiya, H Fitriana, ...
    Jurnal Pengabdian UntukMu NegeRI 10 (1), 187-195 , 2026
    2026.0
  • PEMBERDAYAAN UMKM MELALUI DIVERSIFIKASI OLAHAN BUAH SEMANGKA DI DESA RAWANG AIR PUTIH
    N Aditiya, A Afrizal, MK Sari
    Jurnal Abdimas UM Jambi 3 (1), 29-34 , 2026
    2026.0
  • KINETIKA KIMIA (KONSEP, MODEL MATEMATIS DAN APLIKASINYA DALAM SISTEM ALAM)
    MK Sari, SH Siregar
    https://www.academia.edu/151115942 … , 2026
    2026.0
  • Fun English Day: Meningkatkan Minat Belajar Bahasa Siswa Dasar melalui Kegiatan Pengabdian Masyarakat di Rawang Air Putih
    MK Sari
    Jurnal Pengabdian UntukMu negeRi 9 (3), 474-479 , 2025
    2025.0
    Citations: 2
  • ANALISA PENGUJIAN KADAR NITRAT, NITRIT DAN KLORIDA PADA AIR MINERAL DENGAN METODE SPEKTROFOTOMETRI UV–VIS DAN TITRIMETRI
    R Hidayati, H Nasution, MK Sari
    Jurnal Inovasi Teknik Kimia 10 (4), 24-30 , 2025
    2025.0
  • Reevaluasi Miskonsepsi Struktur Atom Dan Partikel Subatom Serta Implikasinya Terhadap Pemahaman Ilmiah: Studi Literatur
    PC Moneteringtyas, MK Sari, I Pangestika, DN Rohmah, I Masriah
    Journal of Chemistry Sciences and Education 2 (01), 39-46 , 2025
    2025.0
  • RESPONS SISWA TERHADAP PROGRAM SEKOLAH BINAAN SMK SE-RIAU PROGRAM KIMIA FAKULTAS MIPA DAN KESEHATAN UMRI
    H Nasution, SH Siregar, AP Rahayu, J Syahri, Prasetya, R Hilma, R Syafri, ...
    MESTAKA: Jurnal Pengabdian Kepada Masyarakat 4 (1), 064-069 , 2025
    2025.0
  • Analysis of Phosphorus And Potassium As Macronutrients And Zinc As A Micronutrient In Solid Organic Fertilizer Derived From Biowaste As An Applied Science Innovation …
    D David, MK Sari, SH Siregar
    Urecol Journal.Part D: Applied Sciences 5 (2), 1-15 , 2025
    2025.0
  • Synthesis, Antimalarial Activities of Secondary Amine-Substituted Eugenol Compounds Against Plasmodium falciparum and in silico Molecular Docking Analysis
    J Syahri, R Hilma, N Nurlaili, MK Sari, N Frimayanti, AH Ali, J Latip
    Sains Malaysiana 52 (12), 3463-3474 , 2023
    2023.0
    Citations: 9
  • The Study of pH and Ionic Strength on Ni (II) and Pb (II) sorption using Humic Acid-Urea Formaldehyde (AHUF)
    MK Sari, B Rusdiarso
    Indonesian Journal of Chemical Science and Technology (IJCST) 5 (1), 31-41 , 2022
    2022.0
    Citations: 4
  • Indonesian Journal of Chemical State University of Medan
    MK Sari, B Rusdiarso
    Indonesian Journal of Chemical Science and Techonology 5 (1), 31-41 , 2022
    2022.0
    Citations: 5
  • SINTESIS DAN KARAKTERISASI ASAM HUMAT DARI TANAH GAMBUT RIAU TERMODIFIKASI UREA-FORMALDEHIDA SEBAGAI ADSORBEN: STUDI EFEK KEKUATAN ION TERHADAP ADSORPSI Pb(II) DAN Ni(II)
    MK Sari
    http://etd.repository.ugm.ac.id/penelitian/detail/202610 , 2021
    2021.0
  • Adsorption of Pb (II) from Aqueous Solutions onto Humic Acid Modified by Urea-Formaldehyde: Effect of pH, Ionic Strength, Contact Time, and Initial Concentration
    MK Sari, R Basuki, B Rusdiarso
    Indonesian Journal of Chemistry , 2021
    2021.0
    Citations: 11
  • Application of Nanocomposit Of Al2O3/Activated Carbon Prepared by Hydrothermal Process for Phenol Removal
    A Allwar, MK Sari
    JKPK (Jurnal Kimia dan Pendidikan Kimia) 5 (1), 16-23 , 2020
    2020.0
    Citations: 1
  • Synthesis and Characterization of Composite of Al 2 O 3 / Activated Carbon by Hydrothermal Method
    A Allwar, MK Sari, F Rahmawati, AN Amatullah
    Key Engineering Materials 801, 298-303 , 2019
    2019.0
    Citations: 5
  • Synthesis and characterization of composite of Al 2 O 3 /activated carbon from palm oil shell by hydrothermal method
    A Allwar, MK Sari
    AIP Conference Proceedings 2026 (1), 020094 , 2018
    2018.0
    Citations: 3
  • BPA Pada Galon, Perang Dagang atau Bahaya Kesehatan?
    D Assifa, MK Sari

MOST CITED SCHOLAR PUBLICATIONS

  • Adsorption of Pb (II) from Aqueous Solutions onto Humic Acid Modified by Urea-Formaldehyde: Effect of pH, Ionic Strength, Contact Time, and Initial Concentration
    MK Sari, R Basuki, B Rusdiarso
    Indonesian Journal of Chemistry , 2021
    2021.0
    Citations: 11
  • Synthesis, Antimalarial Activities of Secondary Amine-Substituted Eugenol Compounds Against Plasmodium falciparum and in silico Molecular Docking Analysis
    J Syahri, R Hilma, N Nurlaili, MK Sari, N Frimayanti, AH Ali, J Latip
    Sains Malaysiana 52 (12), 3463-3474 , 2023
    2023.0
    Citations: 9
  • Indonesian Journal of Chemical State University of Medan
    MK Sari, B Rusdiarso
    Indonesian Journal of Chemical Science and Techonology 5 (1), 31-41 , 2022
    2022.0
    Citations: 5
  • Synthesis and Characterization of Composite of Al 2 O 3 / Activated Carbon by Hydrothermal Method
    A Allwar, MK Sari, F Rahmawati, AN Amatullah
    Key Engineering Materials 801, 298-303 , 2019
    2019.0
    Citations: 5
  • The Study of pH and Ionic Strength on Ni (II) and Pb (II) sorption using Humic Acid-Urea Formaldehyde (AHUF)
    MK Sari, B Rusdiarso
    Indonesian Journal of Chemical Science and Technology (IJCST) 5 (1), 31-41 , 2022
    2022.0
    Citations: 4
  • Synthesis and characterization of composite of Al 2 O 3 /activated carbon from palm oil shell by hydrothermal method
    A Allwar, MK Sari
    AIP Conference Proceedings 2026 (1), 020094 , 2018
    2018.0
    Citations: 3
  • Fun English Day: Meningkatkan Minat Belajar Bahasa Siswa Dasar melalui Kegiatan Pengabdian Masyarakat di Rawang Air Putih
    MK Sari
    Jurnal Pengabdian UntukMu negeRi 9 (3), 474-479 , 2025
    2025.0
    Citations: 2
  • Application of Nanocomposit Of Al2O3/Activated Carbon Prepared by Hydrothermal Process for Phenol Removal
    A Allwar, MK Sari
    JKPK (Jurnal Kimia dan Pendidikan Kimia) 5 (1), 16-23 , 2020
    2020.0
    Citations: 1
  • Pemantauan Kandungan Logam pada Pupuk dan Limbah Palm Oil Mill Effluent (POME) di Riau menggunakan Atomic Absorbtion Spectroscopy (AAS) dalam Mendukung Tujuan Pembangunan …
    MK Sari
    Proceedings National Conference Sinesia 2 (1), 299-317 , 2026
    2026.0
  • Pemantauan Logam pada Pupuk dan POME menggunakan AAS untuk Industri Sawit Berkelanjutan di Riau
    MK Sari, SH Siregar, D David, MW Nugraha, AA Manurung
    National Conference Sinesia III | Tut Wuri Handayani 3 (2), 299-317 , 2026
    2026.0
  • Pemanfaatan Asam humat dari Gambut Degradasi Riau untuk Adsorpsi Logam Berat Berkelanjutan
    MK Sari, B Rusdiarso, DR Eliana, SH Siregar
    National Conference Sinesia III | Tut Wuri Handayani 3 (2), 281-298 , 2026
    2026.0
  • Penguatan Kesadaran Digital Masyarakat terhadap Ancaman Siber dan Judi Online melalui Program KKN MAs
    MK Sari, M Tauhid, MNI Hasbi, E Alkautsar, N Aditiya, H Fitriana, ...
    Jurnal Pengabdian UntukMu NegeRI 10 (1), 187-195 , 2026
    2026.0
  • PEMBERDAYAAN UMKM MELALUI DIVERSIFIKASI OLAHAN BUAH SEMANGKA DI DESA RAWANG AIR PUTIH
    N Aditiya, A Afrizal, MK Sari
    Jurnal Abdimas UM Jambi 3 (1), 29-34 , 2026
    2026.0
  • KINETIKA KIMIA (KONSEP, MODEL MATEMATIS DAN APLIKASINYA DALAM SISTEM ALAM)
    MK Sari, SH Siregar
    https://www.academia.edu/151115942 … , 2026
    2026.0
  • ANALISA PENGUJIAN KADAR NITRAT, NITRIT DAN KLORIDA PADA AIR MINERAL DENGAN METODE SPEKTROFOTOMETRI UV–VIS DAN TITRIMETRI
    R Hidayati, H Nasution, MK Sari
    Jurnal Inovasi Teknik Kimia 10 (4), 24-30 , 2025
    2025.0
  • Reevaluasi Miskonsepsi Struktur Atom Dan Partikel Subatom Serta Implikasinya Terhadap Pemahaman Ilmiah: Studi Literatur
    PC Moneteringtyas, MK Sari, I Pangestika, DN Rohmah, I Masriah
    Journal of Chemistry Sciences and Education 2 (01), 39-46 , 2025
    2025.0
  • RESPONS SISWA TERHADAP PROGRAM SEKOLAH BINAAN SMK SE-RIAU PROGRAM KIMIA FAKULTAS MIPA DAN KESEHATAN UMRI
    H Nasution, SH Siregar, AP Rahayu, J Syahri, Prasetya, R Hilma, R Syafri, ...
    MESTAKA: Jurnal Pengabdian Kepada Masyarakat 4 (1), 064-069 , 2025
    2025.0
  • Analysis of Phosphorus And Potassium As Macronutrients And Zinc As A Micronutrient In Solid Organic Fertilizer Derived From Biowaste As An Applied Science Innovation …
    D David, MK Sari, SH Siregar
    Urecol Journal.Part D: Applied Sciences 5 (2), 1-15 , 2025
    2025.0
  • SINTESIS DAN KARAKTERISASI ASAM HUMAT DARI TANAH GAMBUT RIAU TERMODIFIKASI UREA-FORMALDEHIDA SEBAGAI ADSORBEN: STUDI EFEK KEKUATAN ION TERHADAP ADSORPSI Pb(II) DAN Ni(II)
    MK Sari
    http://etd.repository.ugm.ac.id/penelitian/detail/202610 , 2021
    2021.0
  • BPA Pada Galon, Perang Dagang atau Bahaya Kesehatan?
    D Assifa, MK Sari