Veterinary, Animal Science and Zoology, Obstetrics and Gynecology
44
Scopus Publications
832
Scholar Citations
16
Scholar h-index
30
Scholar i10-index
Scopus Publications
Comparative Effects of Aminophylline, Caffeine, and Doxapram in Hypoxic Neonatal Dogs Born by Cesarean Section Júlia Cosenza Mendonça, Keylla Helena Nobre Pacífico Pereira, Gleice Mendes Xavier, Kárita da Mata Fuchs, Thaís Gomes Faustino, et al. Animals, 2025 Background: Perinatal hypoxia is a leading cause of early mortality in canine neonates and accounts for over 90% of early deaths in canine neonates. Respiratory depression may result from dystocia, prolonged labor, or anesthetic protocols used during cesarean delivery, requiring rapid pharmacological support. This study evaluated the effects of aminophylline, caffeine, and doxapram on clinical and biochemical viability parameters in hypoxic neonatal dogs. Methods: Forty-five puppies born via elective or emergency cesarean section were included, of which 35 exhibiting cardiorespiratory depression (heart rate ≤ 180 bpm, respiratory rate < 15 movements per minute, Apgar score < 7, and reflex score < 3) were randomly allocated into aminophylline group (AG; n = 12), caffeine group (CafG; n = 11), or doxapram group (DG; n = 12). Ten clinically healthy neonates constituted the physiological control group (CG). Apgar score, neonatal reflexes, lactate, blood glucose, oxygen saturation, blood gas parameters, and cardiac troponin I (cTnI) were evaluated immediately after birth (M1) and 10 min following treatment (M10). Results: No significant differences were observed in laboratory parameters among groups (p > 0.05). Although all evaluated drugs improved clinical status by increasing heart rate, respiratory rate, and reflex scores, caffeine produced the greatest enhancement in vitality. The Δ Apgar score showed a significant difference between CafG and DG (p = 0.0095), while no statistical differences were detected between AG and CafG (p = 0.08) or between AG and GD (p = 0.60). Conclusions: Aminophylline, caffeine, and doxapram supported postnatal resuscitation in hypoxic neonatal puppies; however, caffeine demonstrated superior improvement in Apgar recovery, suggesting its potential as a preferred pharmacological adjunct in neonatal canine resuscitation protocols.
Anencephaly and palatoschisis in 2 newborn puppies Canadian Veterinary Journal La Revue Veterinaire Canadienne, 2025
Impact of Delivery Method on Serum Cortisol Levels and Neonatal Outcomes in Canine Cesarean Sections Renatha Almeida de Araújo, João Domingos Rocha-Júnior, Jaqueline Tamara Bonavina, Melissa de Oliveira Bianchini, Samara Beretta, et al. Animals, 2025 In this study, thirty female dogs, aged one to five years and varying in weight, in the last week of gestation were evaluated. The animals were divided into two groups: GC, which comprised twenty-two bitches undergoing elective cesarean section, and GD, which consisted of eight dogs requiring therapeutic cesarean section as a treatment to dystocia. We found that cortisol levels in the amniotic fluid were significantly higher in pups delivered via elective cesareans (mean: 9.86 ng/mL) compared to those from therapeutic c-sections (mean: 4.11 ng/mL). This observation contrasted with previous studies that reported lower cortisol levels in elective procedures, suggesting complexities in the physiological responses to different delivery methods that warrant further investigation. Notably, our study observed no significant association between amniotic fluid meconium presence and other distress markers, indicating that meconium may be more closely associated with fetal maturation rather than distress (p > 0.05). Neonatal viability (Apgar score) revealed that 92.86% of the neonates from elective procedures demonstrated no distress shortly after delivery, contrasting with 56.25% in therapeutic c-section. Fetal distress can be a direct consequence of dystocia caused by various stressors, such as pain and hypoxia. These factors can impair the fetus’ ability to adapt to extrauterine life, often leading to lower Apgar scores. Notably, neonatal weight was directly related to fetal cortisol levels, while no significant associations were noted between the litter size or birth order and cortisol concentrations, irrespective of the delivery type. These findings underscore the need for ongoing investigation into the relationships between cesarean delivery types, maternal and neonatal stress markers, and resultant health outcomes, aiming to enhance care strategies for expectant canine mothers and their puppies.
Clinical Approach to Cleft Lip and Palate with or Without Surgical Correction in Ten Brachycephalic Puppies Gleice Mendes Xavier, Keylla Helena Nobre Pacífico Pereira, Kárita da Mata Fuchs, Júlia Conseza Mendonça, Rebeca Bastos Abibe, et al. Veterinary Sciences, 2025 Congenital defects are among the leading causes of neonatal mortality in small animals. Among them, cleft palate is one of the most commonly found malformations in dogs. Appropriate clinical management and surgical correction are determining factors for the survival of puppies affected by this alteration. Thus, the objective of this study is to describe 10 clinical cases of successful clinical management of cleft palate, highlighting the therapeutic strategies used, the results obtained, and the evolution of patients after treatment. Ten neonatal dogs of three breeds were treated by the Small Animal Reproduction Service of FMVZ, Unesp—Botucatu: French Bulldog (6), Pug (3), and American Bully (1) presented with cleft palate at birth or during the first week of age. Patients underwent clinical and nutritional management, in addition to immunological support. At four months of age, the patients underwent medially positioned flap repair. The animals were fed via an esophageal tube for 10 days after surgery. The clinical management proved to be effective since, throughout the follow-up, the animals showed good development and did not present complications arising from the cleft palate, and the surgical procedures were successful, restoring the quality of life of the animals.
Vaginal Seeding: Is There Any Positive Effect in Canine C-Sections? Samara Beretta, Renatha Almeida de Araújo, Melissa Oliveira Bianchini, Jaqueline Tamara Bonavina, João Domingos Rocha-Júnior, et al. Animals, 2025 This study aimed to scrutinize variations in the intestinal microbiota of neonatal dogs born through natural birth versus elective cesarean section, focusing on evaluating the influence of vaginal seeding on the microbiota of cesarean-born neonates. Samples were collected from cesarean-sectioned females before anesthesia and from naturally birthing females during prodrome signs, along with neonates at eight time points from birth to 15 days of age. In the cesarean section group, seeding was performed in half of the neonates (cesarean section seeding group; seeding consisted of gently rubbing the gauze, obtained from the mother’s vagina, onto the mouths, faces, and bodies of the newborns), while the other half underwent microbiological sample collection without seeding (cesarean section group). Another group (normal birth group) consisted of naturally born neonates. Microbiota analysis included counting for enterobacteria, Staphylococcus spp., and Streptococcus spp. The results suggested that vertical transmission played a crucial role, but the method of birth did not emerge as the primary determinant of observed differences. Under study conditions, vaginal seeding failed to effectively modulate the microbiota of neonates born through elective cesarean section. Further investigations into the gut–brain axis are suggested for understanding factors influencing the initial development of the canine intestinal microbiota in neonates born through different delivery routes.
Safety Assessment of an Oral Therapeutic Dose of Firocoxib on Healthy Horses Renatha A. Araújo, Nathali A. A. Sales, Roberta C. Basile, Walter H. Feringer-Junior, Maricy Apparício, et al. Veterinary Sciences, 2023 Firocoxib is a non-steroidal anti-inflammatory drug specifically formulated for veterinary medicine and selectively acts on inhibiting the cyclooxygenase 2 enzyme (COX-2). This study evaluated the possible adverse effects of administering oral therapeutic firocoxib on gastric mucosa, hematological parameters, coagulation cascade, and hepatic and renal biochemistry in healthy horses. Nine clinically healthy Arabian horses, approximately 9 years old, received 0.1 mg/kg of oral firocoxib for 14 days. The gastroscopic examination was conducted 1 day before starting treatment (D0) and two days after the last blood collection (D23). Venous blood samples were obtained for laboratory tests on day 1, immediately prior to the initiation of treatment (D1), after 7 and 14 days of treatment (D7 and D14), and 7 days after the conclusion of treatment (D21. No changes were found in the gastroscopic and hematological tests. Coagulation and serum biochemistry levels remain between these species’ average values. However, the increased activated partial thromboplastin time (aPTT) and prothrombin time (PT) indicate reduced blood coagulation capacity, which contradicts the expected effect of treatment with selective COX-2 inhibitors, as these drugs theoretically promote coagulation. Administering firocoxib to horses is safe as it does not cause significant adverse reactions. Therefore, it is a suitable option for managing inflammatory conditions in these animals with attention to an unexpected adverse anti-coagulopathy effect, and further study is warranted.
True vaginal prolapse associated with retroflection of the urinary bladder in a bitch Canadian Veterinary Journal, 2023
Prostatic omentalisation in dogs Maricy Apparício, Wilter Ricardo Russiano Vicente, Eliandra Antônia Pirez, Giuliano Queiroz Mostachio, Ana Paula Coelho Ribeiro, et al. Brazilian Journal of Veterinary Research and Animal Science, 2006
Omentalisation as a treatment for prostatic cysts and abscesses Australian Veterinary Practitioner, 2004
Comparative Effects of Aminophylline, Caffeine, and Doxapram in Hypoxic Neonatal Dogs Born by Cesarean Section JC Mendonça, KHNP Pereira, GM Xavier, KM Fuchs, TG Faustino, ... Animals 15 (23), 3485 , 2025 2025
Histological alterations in placentas of normal and anomalous pups: correlation with neonatal outcomes and fetal health LM Lovo, MV Estevam, S Beretta, A Marmol, LM Pasqui, ... Theriogenology 243, 117458 , 2025 2025 Citations: 2
Effects of aminophylline, caffeine and doxapram in hypoxic neonatal dogs born by caesarean section-Preliminary results JC Mendonca, KH Pereira, G Xavier, K Fuchs, M Apparicio, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Congenital aplasia cutis in a newborn Cavalier King Charles Spaniel dog-Case report JC Mendonca, KH Pereira, K Fuchs, G Xavier, M Apparicio, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
CT and histopathological findings in canine fetal anasarcas FA Rodrigues-Silva, A Hataka, VMV Machado, FB Guimaraes, RO Barreto, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Severe metritis caused by retained placentas in a Queen-Case report RO Barreto, MF Ferreira, DR Gomes, MA Lopes, FF Souza, M Apparicio REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Preputial neoplasms in dogs: A retrospective study RO Barreto, FA Rodrigues-Silva, L Sito-Silva, D Camilo, B Lippe, ... REPRODUCTION IN DOMESTIC ANIMALS 60 , 2025 2025
Impact of Delivery Method on Serum Cortisol Levels and Neonatal Outcomes in Canine Cesarean Sections RA de Araújo, JD Rocha-Júnior, JT Bonavina, MO Bianchini, S Beretta, ... Animals 15 (12), 1739 , 2025 2025
Anencephaly and palatoschisis in 2 newborn puppies MV Estevam, S Beretta, NF Smargiassi, DCJ Armani, MC Maronezi, ... The Canadian Veterinary Journal 66 (6), 628-634 , 2025 2025 Citations: 1
Clinical Approach to Cleft Lip and Palate with or Without Surgical Correction in Ten Brachycephalic Puppies GM Xavier, KHNP Pereira, KM Fuchs, JC Mendonça, RB Abibe, ... Veterinary Sciences 12 (5), 474 , 2025 2025 Citations: 1
Vaginal seeding: is there any positive effect in canine C-sections? S Beretta, RA Araújo, MO Bianchini, JT Bonavina, JD Rocha-Júnior, ... Animals 15 (3), 416 , 2025 2025 Citations: 2
Clinical Approach to Cleft Lip and Palate with or Without Surgical Correction in Ten Brachycephalic Puppies. Vet. Sci. 2025, 12, 474 GM Xavier, K Pereira, KM Fuchs, JC Mendonça, RB Abibe, CVS Brandão, ... development 49, 50 , 2025 2025
Da gestação ao parto: avanços na obstetrícia de cães e gatos M Apparício, MV Estevam, FB Guimarães Rev Bras Reprod Anim 49 (1), 327-334 , 2025 2025
Cryopreservation of canine ovarian tissue by slow freezing and vitrification: evaluation of follicular morphology and apoptosis rate NAL Stábile, FR de Oliveira, RA Furtado, CBML Felippe, MR Tavares, ... Theriogenology 230, 8-14 , 2024 2024 Citations: 9
The most common congenital malformations in dogs: Literature review and practical guide MV Estevam, GH Toniollo, M Apparicio Research in Veterinary Science 171, 105230 , 2024 2024 Citations: 16
Safety Assessment of an Oral Therapeutic Dose of Firocoxib on Healthy Horses RA Araújo, NAA Sales, RC Basile, WH Feringer-Junior, M Apparício, ... Veterinary Sciences 10 (9), 531 , 2023 2023 Citations: 3
Evaluation of the Effect of the Oral Therapeutic Dose of Firocoxib on Healthy Horses RA De Araújo, NAA Sales, RC Basile, WH Feringer-Junior, M Apparício, ... Preprints , 2023 2023
True vaginal prolapse associated with retroflection of the urinary bladder in a bitch S Beretta, M Apparício, P de Castro Moraes, CV Ribeiro, MV Estevam, ... The Canadian Veterinary Journal 64 (3), 252-256 , 2023 2023 Citations: 2
The importance of the intestinal microbiota in humans and dogs in the neonatal period S Beretta, M Apparicio, GH Toniollo, MV Cardozo Animal Reproduction 20, e20230082 , 2023 2023 Citations: 11
In vivo embryo development in bitches inseminated laparoscopically after ovulation time estimated based on a single progesterone determination AE Alves, TF Motheo, MF Apparicio, GQ Mostachio, RM Santos, ... Animal reproduction 20, e20220079 , 2023 2023 Citations: 5
MOST CITED SCHOLAR PUBLICATIONS
Abdominal sequelae after pedicled TRAM flap breast reconstruction JY Petit, M Rietjens, MAR Ferreira, D Montrucoli, E Lifrange, P Martinelli Plastic and reconstructive surgery 99 (3), 723-729 , 1997 1997 Citations: 102
Chemical composition of lipids present in cat and dog oocyte by matrix‐assisted desorption ionization mass spectrometry (MALDI‐MS) M Apparicio, CR Ferreira, A Tata, VG Santos, AE Alves, GQ Mostachio, ... Reproduction in Domestic Animals 47, 113-117 , 2012 2012 Citations: 58
Reprodução e obstetrícia em cães e gatos M APPARÍCIO, WRR VICENTE São Paulo: MedVet, 9-13 , 2015 2015 Citations: 41
Congenital malformations in brachycephalic dogs: A retrospective study MV Estevam, S Beretta, NF Smargiassi, M Apparício, GH Toniollo, ... Frontiers in veterinary science 9, 981923 , 2022 2022 Citations: 40
Omentalização prostática em cãse M Apparício, WRR Vicente, EA Pirez, GQ Mostachio, APC Ribeiro, ... 2006 Citations: 36
Effect of vitrification of feline ovarian cortex on follicular and oocyte quality and competence GC Luvoni, I Tessaro, M Apparicio, E Ruggeri, AM Luciano, SC Modina Reproduction in domestic animals 47 (3), 385-391 , 2012 2012 Citations: 33
A survey of three years consultation: 119 cases of pyometra, prognosis and outcome DG Martins, M Apparicio, WRR Vicente Journal of Animal Science Advances 5 (2), 1202-1207 , 2015 2015 Citations: 27
Intra-prostatic injection of botulinum toxin type A in treatment of dogs with spontaneous benign prostatic hyperplasia GQ Mostachio, M Apparício, TF Motheo, AE Alves, WRR Vicente Animal Reproduction Science 133 (3-4), 224-228 , 2012 2012 Citations: 25
Developmental competence of domestic cat vitrified oocytes in 3D enriched culture conditions M Colombo, MG Morselli, MR Tavares, M Apparicio, GC Luvoni Animals 9 (6), 329 , 2019 2019 Citations: 24
Uterine leucocyte infiltration after artificial insemination in bitches APC Ribeiro, WRR Vicente, M Apparício, CRF Gadelha, AE Alves, ... Theriogenology 66 (6-7), 1462-1464 , 2006 2006 Citations: 23
Leucogram and serum acute phase protein concentrations in queens submitted to conventional or videolaparoscopic ovariectomy AE Alves, APC Ribeiro, PA Di Filippo, MF Apparicio, JJ Fagliari, ... Arquivo Brasileiro de Medicina Veterinária e Zootecnia 62 (1), 86-91 , 2010 2010 Citations: 20
Age-related ultrasonography, cytology, and microbiologic exam of canine prostate CRF Gadelha, WRR Vicente, APC Ribeiro, MF Apparício, GJ Covizzi, ... Arquivo Brasileiro de Medicina Veterinária e Zootecnia 61 (6), 1261-1267 , 2009 2009 Citations: 20
TUMOR VENÉREO TRANSMISSÍVEL (TVT) CANINO NO ÚTERO: RELATO DE CASO. GQ Mostachio, EA Pires-Buttler, M Apparício, DJ Cardilli, WRR Vicente, ... Ars veterinaria 23 (2), 71-74 , 2007 2007 Citations: 20
Acquired vesicovaginal fistula secondary to ovariohysterectomy in a bitch: a case report CRF Gadelha, APC Ribeiro, MF Apparício, GJ Covizzi, WRR Vicente Arquivo Brasileiro de Medicina Veterinária e Zootecnia 56, 183-186 , 2004 2004 Citations: 20
Vitrification of immature feline oocytes with a commercial kit for bovine embryo vitrification M Apparicio, E Ruggeri, GC Luvoni Reproduction in Domestic Animals 48 (2), 240-244 , 2013 2013 Citations: 19
Effects of hormonal supplementation on nuclear maturation and cortical granules distribution of canine oocytes during various reproductive stages M Apparicio, AE Alves, EA Pires‐Butler, APC Ribeiro, GJ Covizzi, ... Reproduction in domestic animals 46 (5), 896-903 , 2011 2011 Citations: 17
The most common congenital malformations in dogs: Literature review and practical guide MV Estevam, GH Toniollo, M Apparicio Research in Veterinary Science 171, 105230 , 2024 2024 Citations: 16
Evaluation of different fragment sizes and cryoprotectants for cryopreservation of feline testicular tissues BI Macente, GH Toniollo, M Apparicio, CFM Mansano, HE Thomé, ... Reproduction in Domestic Animals 52, 242-247 , 2017 2017 Citations: 16
Evaluation of creatine kinase (CK) and aspartate aminotransferase (AST) activities after laparoscopic or conventional ovariectomy in queens AE Alves, APC Ribeiro, PA Filippo, MF Apparicio, TF Motheo, ... Schweizer Archiv Für Tierheilkunde 151 (5), 223-227 , 2009 2009 Citations: 16
Granulosa cells in three‐dimensional culture: A follicle‐like structure for domestic cat vitrified oocytes M Colombo, MG Morselli, M Apparicio, GC Luvoni Reproduction in Domestic Animals 55, 74-80 , 2020 2020 Citations: 14
