Regulation of DNA methylation and demethylation processes in eukaryotic cells;
DNA methylation, modulation of gene expression and cell differentiation;
Molecular mechanisms of the gene therapy by small fragment homologous replacement (SFHR);
Molecular genetics of cystic fibrosis and of CFTR-related disorders, as well as study of the genotype/phenotype relationship in this diseases;
Functional characterization of CFTR (cystic fibrosis transmembrane conductance regulator) and ENaC (epithelial sodium channel) genes in physiologic and pathologic conditions;
Molecular diagnostic methodologies and pathogenetic mechanisms underlying cystic fibrosis, CFTR-related disorders, atherosclerosis, alcohol addiction and neurological disorders;
Setup and automation of mutational search methodologies.
115
Scopus Publications
Scopus Publications
MethPy: a new software for analyzing non-CpG methylation after bisulfite assay and Sanger sequencing Martina Roiati, Luiza Diniz Ferreira Borges, Andrea Cattani, Marco Lucarelli, Andrea Fuso Scientific Reports, 2025 Despite the advent of "methylomic" analyses, bisulfite modification of genomic DNA followed by Sanger sequencing remains the most precise assay for investigating the methylation profile of specific sequences at single-cytosine resolution. We and others highlighted the possibility that cytosine methylation outside the canonical CpG dinucleotides-indicated as "non-CpG" or "CpH" methylation-can be significantly present, particularly in brain cells and tissues and that these non-CpG methyl-groups also display a functional role in modulating gene expression. The sequencing output obtained after bisulfite assay needs to be compared to the reference sequence to identify the modified cytosines. This task can be performed through software-assisted analysis but, so far, limitedly at the CpG moieties. To address this gap, the MethPy software has been developed to analyze non-CpG methylation profiles in an automated manner. MethPy was programmed in Python and enables the comparison of bisulfite-modified sequences with their corresponding genomic ones. The results are immediately showed with the option to show multiple output formats (text, tables, and graphs). To our knowledge, this is the first tool that allows the analysis of non-CpG methylation at single-base resolution and may contribute to streamlining and accelerating the analysis of Sanger sequencing of bisulfite PCR products.
CFTR Modulator Response in Nasal Organoids Derived from People with Cystic Fibrosis Stefania Lo Cicero, Germana Castelli, Aurora Ceci, Anna Maria Cerio, Giovanna Blaconà, Mariarita Virgulti, Sara Allushi, Giovanni Sette, Francesca Spadaro, Felice Amato, Paola Melotti, Claudio Sorio, Giuseppe Cimino, Mauro Biffoni, Marco Lucarelli, Adriana Eramo Cells, 2025 Despite the progressive extension of CFTR variant eligibility to the triple combination of elexacaftor/tezacaftor/ivacaftor (ETI), most rare CFTR pathogenic variants remain ineligible for CFTR modulators. It is crucial to determine whether unexplored variants are rescuable by clinical modulators and to identify innovative therapeutic strategies for rescuing non-responder variants. The approach known as “theratyping” (in vitro testing of genotypes) has been accepted by the Food and Drug Administration (FDA) for the extension of clinical modulators’ approval for in vitro responding genotypes. We used one of the most advanced models for theratyping: organoids derived from nasal epithelia of people with cystic fibrosis (pwCF). We optimized the forskolin-induced swelling (FIS) of organoids to assess CFTR basal or modulator-restored function. Nasal organoids mimicked the original epithelial tissue, CFTR residual activity, and modulator response. We set up the FIS assay using nasal organoids with reference genotypes and theratyped 38 rare (non-F508del) CFTR genotypes, either eligible or non-eligible for FDA approval, for treatment with ETI or ivacaftor. We found strong correspondence between the in vitro response of CFTR variants to modulators and their FDA approval status. Additionally, some previously uncharacterized CFTR variants have proven responsive to clinical modulators, with significant therapeutic implications. These results suggest that the nasal organoid FIS assay, pending confirmation of the prediction in the corresponding pwCF, might be considered as a powerful in vitro tool to predict modulator efficacy in each pwCF, guiding out-of-label prescription in CF, and to identify uncharacterized variants responsive to modulators. This approach may allow comparison of the efficacy of different therapeutics or the identification of innovative strategies for non-responding genotypes, improving personalized therapy and quality of life for pwCF.
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic Daniele Antinori, Marco Lucarelli, Andrea Fuso Essays in Biochemistry, 2025 Alzheimer’s disease (AD) is a neurodegenerative disease, representing the seventh cause of death worldwide and the first cause of dementia. Several pathogenic mechanisms have been connected to this pathology, including protein aggregation, oxidative stress, metabolic dysfunction, mitochondrial dysfunction, neuroinflammation, synaptic dysfunction, and cell death. The etiology of AD is multifactorial, suggesting that, in addition to a genetic component, the environment may strongly influence its onset and progression. Exposure to heavy metals, such as lead, cadmium, mercury, and arsenic (As), is known to be associated with AD, with As showing one of the strongest correlations, in relation to the epigenetic changes. The World Health Organization (WHO) set a very low limit for its concentration to 10 μg/l in drinking water. The possibility that As may induce epigenetic effects is a recent hypothesis. Evidence, so far, suggests that As may induce DNA hypomethylation in the brain, by mechanisms not yet completely disclosed. This minireview aims to provide evidence to support the role of As exposure in AD, maintaining a focus on oxidative stress and ferroptosis, with a perspective on DNA methylation.
One-carbon metabolism modulates miR-29a–DNA methylation crosstalk in Alzheimer's disease Tiziana Raia, Rosaria A. Cavallaro, Luiza Diniz Ferreira Borges, Stefano Cinti, Mariano Bizzarri, Isidre Ferrer, Marco Lucarelli, Andrea Fuso Alzheimer S and Dementia, 2025 INTRODUCTIONAlzheimer's disease (AD)’s multifactorial nature stresses the role of epigenetics in affecting different pathological pathways. We demonstrated that one‐carbon metabolism epigenetically impacts AD‐like phenotype. Here, we investigated the crosstalk between methylation and microRNAs in AD.METHODSWe altered one‐carbon metabolism to induce hypo‐ and hyper‐methylation, in SK‐N‐BE neuroblastoma cells and TgCRND8 mice. miRNAs were profiled through a polymerase chain reaction array, then we focused on miR‐29a expression and methylation of its genomic locus. Finally, we assessed miR‐29a expression and methylation in the brain of AD subjects.RESULTSMiR‐29a was repressed in hypomethylating and expressed in hypermethylating conditions. The expression of miR‐29a and of its target, BACE1, was inversely correlated.DISCUSSIONWe demonstrated for the first time that miR‐29a is modulated by one‐carbon metabolism through DNA methylation, disclosing the molecular mechanisms regulating BACE1 expression in AD. These data confirm miR‐29a’s protective role in AD and support miR‐29a as a potential biomarker for AD.
miRNAs from Zebrafish Embryo Extracts Inhibit Breast Cancer Invasiveness and Migration by Modulating miR-218-5p/PI3K Pathway Noemi Monti, Daniele Antinori, Sara Proietti, Aurora Piombarolo, Alessandro Querqui, Guglielmo Lentini, Domenico Liguoro, Michele Aventaggiato, Marco Lucarelli, Andrea Pensotti, Alessandro Giuliani, Marco Tafani, Andrea Fuso, Mariano Bizzarri International Journal of Molecular Sciences, 2025 Herein, we demonstrate that soluble factors extracted from the distinct phases of the development of zebrafish embryos (ZFEs) exhibit a specific miRNA profile. We removed proteins and concentrated miRNAs in different phase-related samples, which we investigated further. We observed that ZFEs modulate miRNA expression in both normal and cancerous breast cells, significantly inhibiting the invasiveness and motility of triple-negative breast cancer cells. Namely, ZFEs reactivate the synthesis of miR-218-5p in cancerous cells, leading to the downregulation of PI3K, which consequently alters the distribution of phosphoinositides (such as PIP2/PIP3). Moreover, the silencing of miR-218-5p abolished the ZFE effects. Restoring a proper PIP2/PIP3 ratio is crucial for promoting the regression of the malignant phenotype. Phenotypic reversion follows the extensive cytoskeleton rearrangement and the re-emergence of E-cadherin/β-catenin complexes. In addition, ZFEs antagonize the Epithelial Mesenchymal Transition (EMT) by modulating several pathways, including the TCTP-p53 axis. Overall, these results show that embryo extracts enriched with fish miRNAs reactivate endogenous miR-218-5p in cancerous cells, which in turn downregulates critical pathways involved in tumor progression and metastasis.
Alcohol Consumption and Autoimmune Diseases Sergio Terracina, Brunella Caronti, Marco Lucarelli, Silvia Francati, Maria Grazia Piccioni, Luigi Tarani, Mauro Ceccanti, Micaela Caserta, Loredana Verdone, Sabrina Venditti, Marco Fiore, Giampiero Ferraguti International Journal of Molecular Sciences, 2025 Alcohol is the second-most misused substance after tobacco. It has been identified as a causal factor in more than 200 diseases and 5.3% of all deaths and is associated with significant behavioral, social, and economic difficulties. As alcohol consumption may modulate the immune system’s regulatory mechanisms to avoid attacking the body’s tissues, it has been proven to play a dichotomic role in autoimmune diseases (ADs) based on the quantity of consumption. In this review, we report updated evidence on the role of alcohol in ADs, with a focus on alcohol addiction and the human biological immune system and the relationship between them, with alcohol as a risk or protective factor. Then, in this narrative review, we report the main evidence on the most studied ADs where alcohol represents a key modulator, including autoimmune thyroiditis, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, diabetes, allergic rhinitis, and primary biliary cholangitis. Alcohol at low–moderate dosages seems mostly to have a protective role in these diseases, while at higher dosages, the collateral risks surpass possible benefits. The specific mechanisms by which low-to-moderate alcohol intake relieves AD symptoms are not yet fully understood; however, emerging studies suggest that alcohol may have a systemic immunomodulatory effect, potentially altering the balance of anti-inflammatory innate and adaptive immune cells, as well as cytokines (via the NF-κB or NLRP3 pathways). It might influence the composition of the gut microbiome (increasing amounts of beneficial gut microbes) and the production of their fatty acid metabolites, such as short-chain fatty acids (SCFAs) and polyunsaturated fatty acids (PUFAs), as well as elevated concentrations of acetate, high-density lipoprotein (HDL), and nitric oxide (NO). Unfortunately, a definite acceptable daily intake (ADI) of ethanol is complicated to establish because of the many mechanisms associated with alcohol consumption such that despite the interesting content of these findings, there is a limit to their applicability and risks should be weighed in cases of alcoholic drinking recommendations. The aim of future studies should be to modulate those beneficial pathways involved in the alcohol-protective role of ADs with various strategies to avoid the risks associated with alcohol intake.
Alcohol Consumption and Breast and Ovarian Cancer Development: Molecular Pathways and Mechanisms F. Fanfarillo, Brunella Caronti, Marco Lucarelli, Silvia Francati, Luigi Tarani, Mauro Ceccanti, M. Piccioni, L. Verdone, M. Caserta, Sabrina Venditti, G. Ferraguti, Marco Fiore Current Issues in Molecular Biology, 2024 Alcohol consumption has been consistently linked to an increased risk of several cancers, including breast and ovarian cancer. Despite substantial evidence supporting this association, the precise mechanisms underlying alcohol’s contribution to cancer pathogenesis remain incompletely understood. This narrative review focuses on the key current literature on the biological pathways through which alcohol may influence the development of breast and ovarian cancer. Key mechanisms discussed include the modulation of estrogen levels, the generation of reactive oxygen species, the production of acetaldehyde, the promotion of chronic inflammation, and the induction of epigenetic changes. Alcohol’s impact on estrogenic signaling, particularly in the regulation of estrogen and progesterone, is explored in the context of hormone-dependent cancers. Additionally, the role of alcohol-induced DNA damage, mutagenesis, and immune system modulation in tumor initiation and progression is examined. Overall, this review emphasizes the importance of alcohol as a modifiable risk factor for breast and ovarian cancer and highlights the need for further research to clarify its role in cancer biology.
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: clinical hallmarks Michela Menghi, Ginevra Micangeli, Roberto Paparella, M. Ceccanti, Giovanna Coriale, Giampiero Ferraguti, M. Fiore, Daniela Fiorentino, M. Piccioni, Luigi Tarani Rivista Di Psichiatria, 2024 Riassunto. Il disturbo dello spettro feto-alcolico (FASD) è una condizione che si verifica quando una persona è esposta all'alcol durante la gravidanza. Le principali manifestazioni cliniche includono anomalie craniofacciali, ritardo della crescita, difetti alla nascita e cambiamenti nella struttura e nella funzione del cervello. Queste alterazioni possono causare deficit nelle capacità cognitive, nella funzione esecutiva, nella memoria, nella vista, nell'udito, nelle capacità motorie, nel comportamento e nell'adattamento sociale. Gli effetti dell'alcol si estendono oltre il cervello, influenzando altri sistemi tra cui organi sensoriali, cuore e reni. Dato che la diagnosi di FASD implica l'esclusione di altre condizioni, i medici devono avere familiarità con le sue caratteristiche principali per facilitare l'identificazione precoce e implementare strategie sanitarie appropriate per la paziente. Inoltre, c'è un'urgente necessità di strategie di prevenzione primaria incentrate sulla sensibilizzazione sui rischi associati al consumo di alcol durante la gravidanza. Gli articoli estratti in questa rassegna mirano ad analizzare e valutare studi incentrati sulle caratteristiche cliniche osservate nei bambini con la FASD; sono stati reperiti da database online come Medline, Medline Complete e PubMed, che coprono la letteratura pubblicata in lingua inglese tra il 1981 e il 2024, utilizzando termini di ricerca come disturbi dello spettro feto-alcolico, sindrome feto-alcolica, esposizione prenatale all'alcol e difetti alla nascita correlati all'alcol. I dati sottolineano che l'esposizione prenatale all'alcol colpisce principalmente il cervello e le sue funzioni, con conseguenti gravi impatti. Inoltre, si osservano frequentemente anomalie in altri organi vitali come i sistemi sensoriale, cardiovascolare e renale.
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: detecting alcohol drinking during pregnancy Giampiero Ferraguti, Francesca Fanfarillo, Simona Nicotera, Sergio Terracina, Clementina Moschella, Alessandro Mattia, Maria Chiara David, S. Pichini, Giovanna Coriale, Daniela Fiorentino, M. Ceccanti, M. Piccioni, Luigi Tarani, M. Fiore Rivista Di Psichiatria, 2024 Riassunto. Il disturbo dello spettro feto-alcolico (FASD) è un termine onnicomprensivo utilizzato per descrivere una serie di disturbi causati dal consumo di alcol durante la gestazione. Gli effetti dannosi si manifestano principalmente nel sistema nervoso centrale, nella crescita e nelle caratteristiche facciali distintive. Dato che non esistono trattamenti noti per il FASD, lo screening meticoloso per questa condizione nelle prime fasi della gravidanza ha un significato immenso, limitando le gravi conseguenze derivanti dall'esposizione all'alcol in utero. Le misure di screening per la FASD comprendono la valutazione dei biomarcatori dell'alcol come il fosfatidiletanolo (PEth) nel flusso sanguigno materno, gli esteri etilici degli acidi grassi (FAEE) nel meconio e l'etilglucuronide (EtG) nel meconio, nelle urine materne e nei capelli. In particolare, l'EtG urinario è altamente sensibile e potrebbe essere utilizzato di routine nelle donne in gravidanza per rilevare anche il consumo occasionale. Sono inoltre disponibili valutazioni tramite questionari tra cui AUDIT-C, T-ACE e TWEAK, insieme a un diario alimentare per identificare l'abuso di alcol e le gravidanze ad alto rischio. Tuttavia, questi questionari potrebbero fornire un quadro inadeguato del consumo di alcol nelle donne a causa della loro inclinazione a mentire per conformarsi alle aspettative socioculturali prevalenti. Pertanto, questo lavoro evidenzia l'indispensabile integrazione del rilevamento dei biomarcatori dell'alcol nel corso del monitoraggio della gravidanza, poiché costituisce uno strumento prezioso per facilitare la scoperta precoce di un eventuale FASD.
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: structural abnormalities Sergio Terracina, Giampiero Ferraguti, Francesca Fanfarillo, Giovanna Coriale, Mauro Ceccanti, et al. Rivista Di Psichiatria, 2024 Fetal Alcohol Spectrum Disorders (FASD) encompass a range of conditions caused by prenatal alcohol consumption, leading to physical, behavioral, and learning challenges. It is a significant cause of preventable mental disability, with a prevalence rate of 7.7 cases per 1,000 individuals in the Western world. FASD includes various categories such as alcohol-related neurodevelopmental disorders (ARND), alcohol-related birth defects (ARBD), partial fetal alcohol syndrome (pFAS), and FAS. Mortality is primarily linked to external causes and individuals with FAS may have a projected lifespan of around 34 years. This review highlights the key features of FASD, including neurological impact, behavioral abnormalities, placental and congenital malformations, organic abnormalities, and hormonal and immune disruption. Additionally, potential therapeutic approaches for FASD are briefly discussed based on the different manifestations. Prevention remains the most effective strategy to reduce its incidence, although the general population’s understanding of this topic is currently insufficient. Timely diagnosis and intervention are crucial as they can significantly enhance outcomes through appropriate support and management strategies. Increasing awareness among citizens about the detrimental effects of alcohol use disorders on newborn health is of utmost importance.
Nerve Growth Factor and the Role of Inflammation in Tumor Development Giampiero Ferraguti, Sergio Terracina, Luigi Tarani, Francesca Fanfarillo, Sara Allushi, Brunella Caronti, Paola Tirassa, Antonella Polimeni, Marco Lucarelli, Luca Cavalcanti, Antonio Greco, Marco Fiore Current Issues in Molecular Biology, 2024
In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells Karina Kleinfelder, Virginia Lotti, Adriana Eramo, Felice Amato, Stefania Lo Cicero, Germana Castelli, Francesca Spadaro, Alessia Farinazzo, Daniele Dell’Orco, Sara Preato, Jessica Conti, Luca Rodella, Francesco Tomba, Angelo Cerofolini, Elena Baldisseri, Marina Bertini, Sonia Volpi, Valeria Rachela Villella, Speranza Esposito, Immacolata Zollo, Giuseppe Castaldo, Carlo Laudanna, Eric J. Sorsher, Jeong Hong, Disha Joshi, Garry Cutting, Marco Lucarelli, Paola Melotti, Claudio Sorio Iscience, 2023
Nerve Growth Factor and Autoimmune Diseases Sergio Terracina, Giampiero Ferraguti, Luigi Tarani, Francesca Fanfarillo, Paola Tirassa, Massimo Ralli, Giannicola Iannella, Antonella Polimeni, Marco Lucarelli, Antonio Greco, Marco Fiore Current Issues in Molecular Biology, 2023
The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study Marco Fiore, Antonio Minni, Luca Cavalcanti, Giammarco Raponi, Gianluca Puggioni, Alessandro Mattia, Sara Gariglio, Andrea Colizza, Piero Giuseppe Meliante, Federica Zoccali, Luigi Tarani, Christian Barbato, Marco Lucarelli, Flavio Maria Ceci, Silvia Francati, Giampiero Ferraguti, Mauro Ceccanti, Carla Petrella Antioxidants, 2023
Blood Biomarkers from the Emergency Department Disclose Severe Omicron COVID-19-Associated Outcomes Fiorenza Pennacchia, Eqrem Rusi, Wael Abu Ruqa, Maria Antonella Zingaropoli, Patrizia Pasculli, Giuseppina Talarico, Giuseppe Bruno, Christian Barbato, Antonio Minni, Luigi Tarani, Gioacchino Galardo, Francesco Pugliese, Marco Lucarelli, Giampiero Ferraguti, Maria Rosa Ciardi, Marco Fiore Microorganisms, 2023
NGF and BDNF in pediatrics syndromes Giampiero Ferraguti, Sergio Terracina, Ginevra Micangeli, Marco Lucarelli, Luigi Tarani, Mauro Ceccanti, Matteo Spaziani, Valerio D’Orazi, Carla Petrella, Marco Fiore Neuroscience and Biobehavioral Reviews, 2023
Sperm DNA Fragmentation and Sperm-Borne miRNAs: Molecular Biomarkers of Embryo Development? Anna Chiara Conflitti, Gaia Cicolani, Alessandra Buonacquisto, Francesco Pallotti, Fabiana Faja, Serena Bianchini, Giovanna Blaconà, Sabina Maria Bruno, Antonella Linari, Marco Lucarelli, Diletta Montanino, Ludovico Muzii, Andrea Lenzi, Francesco Lombardo, Donatella Paoli International Journal of Molecular Sciences, 2023
Investigating Biomarkers for COVID-19 Morbidity and Mortality Marco Fiore, Flavio Maria Ceci, Giampiero Ferraguti, Marco Lucarelli, Antonio Angeloni, Enea Bonci, Carla Petrella, Silvia Francati, Christian Barbato, Maria Grazia Di Certo, Francesca Gabanella, Francesca Gavaruzzi, Claudio Maria Mastroianni, Antonio Minni, Antonio Greco, Massimo Ralli, Mauro Ceccanti, Luigi Tarani Current Topics in Medicinal Chemistry, 2023
Clinical outcomes of a large cohort of individuals with the F508del/5T;TG12 CFTR genotype Antonella Tosco, Alice Castaldo, Carla Colombo, Laura Claut, Vincenzo Carnovale, Paola Iacotucci, Marco Lucarelli, Giuseppe Cimino, Benedetta Fabrizzi, Nicole Caporelli, Fabio Majo, Fabiana Ciciriello, Rita Padoan, Piercarlo Poli, Giovanni Taccetti, Claudia Centrone, Rosaria Casciaro, Carlo Castellani, Donatello Salvatore, Carmela Colangelo, Paolo Bonomi, Giuseppe Castaldo, Vito Terlizzi Journal of Cystic Fibrosis, 2022
Early Routine Biomarkers of SARS-CoV-2 Morbidity and Mortality: Outcomes from an Emergency Section Flavio Maria Ceci, Marco Fiore, Francesca Gavaruzzi, Antonio Angeloni, Marco Lucarelli, Carolina Scagnolari, Enea Bonci, Francesca Gabanella, Maria Grazia Di Certo, Christian Barbato, Carla Petrella, Antonio Greco, Marco De Vincentiis, Massimo Ralli, Claudio Passananti, Roberto Poscia, Antonio Minni, Mauro Ceccanti, Luigi Tarani, Giampiero Ferraguti Diagnostics, 2022
Safety of multiple vaccinations and durability of vaccine‐induced antibodies in an Italian military cohort 5 years after immunization Claudia Ferlito, Vincenzo Visco, Roberto Biselli, Maria Sofia Cattaruzza, Giulia Carreras, Gerardo Salerno, Florigio Lista, Maria Rosaria Capobianchi, Concetta Castilletti, Daniele Lapa, Guido Antonelli, Massimo Gentile, Maurizio Sorice, Gloria Riitano, Giuseppe Lucania, Valeria Riccieri, Fabrizio Mainiero, Antonio Angeloni, Marco Lucarelli, Giampiero Ferraguti, Alberto Autore, Marco Lastilla, Simonetta Salemi, Michela Ileen Biondo, Andrea Picchianti-Diamanti, Sara Caporuscio, Raffaela Teloni, Sabrina Mariotti, Roberto Nisini, Raffaele D’Amelio Biomedicines, 2022
Vitamin K deficiency and covid-19 Emanuela Anastasi, Cristiano Ialongo, Raffaella Labriola, Giampiero Ferraguti, Marco Lucarelli, Antonio Angeloni Scandinavian Journal of Clinical and Laboratory Investigation, 2020
Trans-heterozygosity for mutations enhances the risk of recurrent/chronic pancreatitis in patients with Cystic Fibrosis Valentina Maria Sofia, Cecilia Surace, Vito Terlizzi, Letizia Da Sacco, Federico Alghisi, Antonella Angiolillo, Cesare Braggion, Natalia Cirilli, Carla Colombo, Antonella Di Lullo, Rita Padoan, Serena Quattrucci, Valeria Raia, Giuseppe Tuccio, Federica Zarrilli, Anna Cristina Tomaiuolo, Antonio Novelli, Vincenzina Lucidi, Marco Lucarelli, Giuseppe Castaldo, Adriano Angioni Molecular Medicine, 2018
Serum urate and uric acid excretion Advances in Experimental Medicine and Biology, 1991
Detritus food webs in three lakes of Central Italy: effects of species delections on structure and function Ecologia Atti 3 Congresso Della Societa Italiana Di Ecologia Siena 1987 Tomo 2, 1989
