Scopus Publications
- Case report: Spatiotemporal HER2 heterogeneity in AFP-producing gastric cancer: navigating long-term survival with molecularly-guided therapy in a refractory case
Yanwen Diao, Haobo Yin, Xin Sun, Qian Dong, Jingdong Zhang
Frontiers in Immunology, 2026
Alpha-fetoprotein-producing gastric cancer (AFPGC) is a rare, aggressive subtype with poor prognosis. We report a metastatic AFPGC case showing spatiotemporal human epidermal growth factor receptor 2 (HER2) heterogeneity. Following progression on first-line FLOT chemotherapy, the 65-year-old male received second-line apatinib plus programmed death-1 (PD-1) inhibitor. At progression (27 months), a lymph node biopsy revealed HER2 conversion from 1+ to 3 +. Third-line anti-HER2 antibody-drug conjugate (ADC) DP303c rapidly achieved partial response with normalized AFP. Despite treatment discontinuation due to neurotoxicity after 5 cycles, response persisted. Overall survival reached 79 months. This case highlights: 1) efficacy of anti-angiogenic and immunotherapy in AFPGC; 2) necessity of re-biopsy for detecting HER2 heterogeneity; and 3) potent activity of ADCs against HER2-converted metastases, enabling remarkable survival through sequential precision therapy. - Tumor-Derived Alpha-1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang
Advanced Science, 2026
Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving neutrophil extracellular traps (NETs) and the transmembrane protein coiled‐coil domain‐containing protein 25 (CCDC25). We demonstrate that A1AT, highly expressed by a liver‐metastatic CRC cell line established in a mouse model, directly induces NETs’ formation. Simultaneously, intracellular A1AT binds to CCDC25, preventing its lysosomal degradation and thereby increasing its surface expression. This A1AT‐mediated upregulation of CCDC25 sensitizes tumor cells to surrounding NET–DNA. Upon engagement, the ILK–RAC1–CDC42 signaling cascade activates, driving extensive cytoskeletal rearrangement and enhancing the migratory and invasive capabilities of CRC cells. Collectively, our findings elucidate a mechanism wherein tumor cells exploit the A1AT–NET–CCDC25 axis to manipulate neutrophil function and boost metastatic potential. This axis represents a critical driver of CRC liver metastasis, offering novel biomarkers and promising therapeutic targets. - Corrigendum to “SKP2 contributes to AKT activation by ubiquitination degradation of PHLPP1, impedes autophagy, and facilitates the survival of thyroid carcinoma” [Molecules and Cells Volume 46, Issue 6, June 2023, 360-373] (Molecules and Cells (2023) 46(6) (360–373), (S1016847823000456), (10.14348/molcells.2022.2242))
Yuan Shao, Wanli Ren, Hao Dai, Fangli Yang, Xiang Li, Shaoqiang Zhang, Junsong Liu, Xiaobao Yao, Qian Zhao, Xin Sun, Zhiwei Zheng, Chongwen Xu
Molecules and Cells, 2025 - Ginsenoside Rk1 inhibits the malignant progression of lung cancer by inactivating the INSR/PI3K/AKT pathway
Ning Du, Dingli Song, Xin Sun, Hong Ren, Yunfeng Zhang
Tissue and Cell, 2025 - Serum TUBB is a potential biomarker for the diagnosis of non-small cell lung cancer
Ning Du, Dingli Song, Dapeng Liu, Xin Liu, Xin Sun, Guangjian Zhang, Hong Ren, Yunfeng Zhang
Journal of Cancer Metastasis and Treatment, 2025
Aim: To identify serum biomarkers for non-small cell lung cancer (NSCLC) and assess their potential for early diagnosis. Experimental: MB-WCX coupled with MALDI-TOF MS was utilized to profile serum samples from 64 NSCLC patients and 64 healthy subjects, followed by ClinProTools software and Liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS) for recognition and characterization of differentially expressed peaks. Enzyme-linked immunosorbent assay (ELISA) confirmed protein concentrations, while The Cancer Genome Atlas (TCGA) database was leveraged for validation of candidate biomarkers in a larger cohort. Results: 39 distinct proteomic m/z peaks were identified for NSCLC subjects, with five of these peaks significantly distinguishing NSCLC from healthy controls (HC). A model developed using the GA (Genetic Algorithm) with ClinProt data demonstrated a sensitivity of 84.72% and a specificity of 88.68% in identifying NSCLC patients. Peaks 2 through 5 were observed to be downregulated in the NSCLC group. Notably, a peptide peak, Peak 1, with an m/z value of 1,866, identified as a fragment of TUBB, was upregulated in NSCLC. ELISA validated the increased serum TUBB levels in NSCLC patients (P < 0.001). Furthermore, analysis of TUBB expression in lung cancer tissues through TCGA data revealed elevated TUBB expression in lung cancer tissues. Conclusions: Serum TUBB is identified as a potential diagnostic biomarker for NSCLC, which may benefit early diagnosis and enhance the survival rate of NSCLC patients. - RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma
Jinxiang Zhu, Longwei Guo, Hao Dai, Zhiwei Zheng, Jinfeng Yan, Junsong Liu, Shaoqiang Zhang, Xiang Li, Xin Sun, Qian Zhao, Chongwen Xu
Cell Biology and Toxicology, 2024
Background RING Finger Protein 115 (RNF115), a notable E3 ligase, is known to modulate tumorigenesis and metastasis. In our investigation, we endeavor to unravel the putative function and inherent mechanism through which RNF115 influences the evolution of thyroid carcinoma (THCA). Methods We analyzed RNF115 expression in THCA using the Cancer Genome Atlas (TCGA) database. The influence of RNF115 on the progression of THCA was evaluated using both in vitro and in vivo experimental approaches. The protein regulated by RNF115 was identified through bioinformatics analysis, and its biological significance was further explored. Results In both THCA tissues and cells, RNF115 showed elevated expression levels. Enhanced expression of RNF115 fostered cell proliferation, tumor growth, and the exacerbation of epithelial-mesenchymal transition (EMT) in THCA, while also promoting tumor lung metastasis. Bioinformatics analysis identified cyclin-dependent kinase 10 (CDK10) as a downstream target of RNF115, which was found to be ubiquitinated and degraded by RNF115 in THCA cells. Functionally, overexpression of CDK10 was found to counteract the promotion of malignant phenotype in THCA induced by RNF115. From a mechanistic perspective, RNF115 activated the Raf-1 pathway and enhanced cancer cell cycle progression by degrading CDK10 in THCA cells. Conclusion RNF115 triggers cell proliferation, EMT, and tumor metastasis by ubiquitinating and degrading CDK10. The regulation of the Raf-1 pathway and cell cycle progression in THCA may be profoundly influenced by this process. - Refining the optimal CAF cluster marker for predicting TME-dependent survival expectancy and treatment benefits in NSCLC patients
Kai Li, Rui Wang, Guo-Wei Liu, Zi-Yang Peng, Ji-Chang Wang, Guo-Dong Xiao, Shou-Ching Tang, Ning Du, Jia Zhang, Jing Zhang, Hong Ren, Xin Sun, Yi-Ping Yang, Da-Peng Liu
Scientific Reports, 2024
The tumor microenvironment (TME) plays a pivotal role in the onset, progression, and treatment response of cancer. Among the various components of the TME, cancer-associated fibroblasts (CAFs) are key regulators of both immune and non-immune cellular functions. Leveraging single-cell RNA sequencing (scRNA) data, we have uncovered previously hidden and promising roles within this specific CAF subgroup, paving the way for its clinical application. However, several critical questions persist, primarily stemming from the heterogeneous nature of CAFs and the use of different fibroblast markers in various sample analyses, causing confusion and hindrance in their clinical implementation. In this groundbreaking study, we have systematically screened multiple databases to identify the most robust marker for distinguishing CAFs in lung cancer, with a particular focus on their potential use in early diagnosis, staging, and treatment response evaluation. Our investigation revealed that COL1A1, COL1A2, FAP, and PDGFRA are effective markers for characterizing CAF subgroups in most lung adenocarcinoma datasets. Through comprehensive analysis of treatment responses, we determined that COL1A1 stands out as the most effective indicator among all CAF markers. COL1A1 not only deciphers the TME signatures related to CAFs but also demonstrates a highly sensitive and specific correlation with treatment responses and multiple survival outcomes. For the first time, we have unveiled the distinct roles played by clusters of CAF markers in differentiating various TME groups. Our findings confirm the sensitive and unique contributions of CAFs to the responses of multiple lung cancer therapies. These insights significantly enhance our understanding of TME functions and drive the translational application of extensive scRNA sequence results. COL1A1 emerges as the most sensitive and specific marker for defining CAF subgroups in scRNA analysis. The CAF ratios represented by COL1A1 can potentially serve as a reliable predictor of treatment responses in clinical practice, thus providing valuable insights into the influential roles of TME components. This research marks a crucial step forward in revolutionizing our approach to cancer diagnosis and treatment. - Author Correction: The immunotherapy candidate TNFSF4 may help the induction of a promising immunological response in breast carcinomas (Scientific Reports, (2021), 11, 1, (18587), 10.1038/s41598-021-98131-4)
Kai Li, Lei Ma, Ye Sun, Xiang Li, Hong Ren, Shou-Ching Tang, Xin Sun
Scientific Reports, 2023
The original version of this Article contained an error in Figure 6, panel E, where the labeling of the flow cytometry antibody gate and thresholds was incorrect. Additionally, the manually added scale number and the gates data have been deleted. The original Figure 6 and accompanying legend appear below. Figure 6 Exploration of the putative clinical roles of TNFSF4. ( A ) IHC staining images are shown to clarify different expression patterns (left to right, in sequence, < 25%, 25–75%, and > 75%). A lymph node slide was set as a positive control, and an unstained slide was set as a negative control. ( B ) High RNA expression of TNFSF4 was universally identified in breast carcinoma, with testing and calculation based on FPKM, and the cutoff line is labeled, which was used for clinical predictions. ( C , D ) Higher TNFSF4 expression pointed to poorer survival outcomes. ( E , F ) Flow cytometry with FACSAria sorting was applied to isolate stem cells from ZR75-1, MCF-7, and MM-231 cells. ( G , H ) Stem cells with a CD44 + /24 − or ALDH1A1 + phenotype were identified and isolated, and the TNFSF4 expression patterns in different cell lines were checked to illustrate the increased expression. Full size image - Correction: M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way (Journal of Experimental & Clinical Cancer Research, (2021), 40, 1, (325), 10.1186/s13046-021-02137-9)
Kai Li, Zi-Yang Peng, Shan Gao, Qing-Shi Wang, Rui Wang, Xiang Li, Guo-Dong Xiao, Jing Zhang, Hong Ren, Shou-Ching Tang, Xin Sun
Journal of Experimental and Clinical Cancer Research, 2023 - Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
Kai Li, Zi-Yang Peng, Rui Wang, Xiang Li, Ning Du, Da-Peng Liu, Jia Zhang, Yun-Feng Zhang, Lei Ma, Ye Sun, Shou-Ching Tang, Hong Ren, Yi-Ping Yang, Xin Sun
Molecular Cancer, 2023
Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational points in the EGFR gene have significantly reduced suffering and provided greater relief to patients with lung adenocarcinoma (LUAD). The third-generation EGFR-TKI, Osimertinib, has been successfully employed in clinical treatments to overcome resistance to both original and acquired T790M and L858R mutational points. Nevertheless, the issue of treatment failure response has emerged as an insurmountable problem. Methods By employing a combination of multiple and integrated approaches, we successfully identified a distinct population within the tumor group that plays a significant role in carcinogenesis, resistance, and recurrence. Our research suggests that addressing TKI resistance may involve targeting the renewal and repopulation of stem-like cells. To investigate the underlying mechanisms, we conducted RNA Microarray and m6A Epi-Transcriptomic Microarray analyses, followed by assessment of transcription factors. Additionally, we specifically designed a tag to detect the polypeptide circRNA-AA, and its expression was confirmed through m6A regulations. Results We initially identified unique molecular signatures present in cancer stem cells that contributed to poor therapeutic responses. Activation of the alternative Wnt pathway was found to sustain the renewal and resistant status of these cells. Through bioinformatics analysis and array studies, we observed a significant decrease in the expression of circFBXW7 in Osimertinib-resistant cell lines. Notably, the abnormal expression pattern of circFBXW7 determined the cellular response to Osimertinib. Functional investigations revealed that circFBXW7 inhibits the renewal of cancer stem cells and resensitizes both resistant LUAD cells and stem cells to Osimertinib. In terms of the underlying mechanism, we discovered that circFBXW7 can be translated into short polypeptides known as circFBXW7-185AA. These polypeptides interact with β-catenin in an m6A-dependent manner. This interaction leads to reduced stability of β-catenin by inducing subsequent ubiquitination, thereby suppressing the activation of canonical Wnt signaling. Additionally, we predicted that the m6A reader, YTHDF3, shares common binding sites with hsa-Let-7d-5p. Enforced expression of Let-7d post-transcriptionally decreases the levels of YTHDF3. The repression of Let-7d by Wnt signaling releases the stimulation of m6A modification by YTHDF3, promoting the translation of circFBXW7-185AA. This creates a positive feedback loop contributing to the cascade of cancer initiation and promotion. Conclusions Our bench study, in vivo experiments, and clinical validation have unequivocally shown that circFBXW7 effectively inhibits the abilities of LUAD stem cells and reverses resistance to TKIs by modulating Wnt pathway functions through the action of circFBXW7-185AA on β-catenin ubiquitination and inhibition. The regulatory role of circRNA in Osimertinib treatment has been rarely reported, and our findings reveal that this process operates under the influence of m6A modification. These results highlight the tremendous potential of this approach in enhancing therapeutic strategies and overcoming resistance to multiple TKI treatments. - Erratum: Correction: MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells (Oncotarget)
Guodong Xiao, Xiang Li, Gang Li, Boxiang Zhang, Chongwen Xu, Sida Qin, Ning Du, Jichang Wang, Shou-Ching Tang, Jing Zhang, Hong Ren, Ke Chen, Xin Sun
Oncotarget, 2023 - SKP2 Contributes to AKT Activation by Ubiquitination Degradation of PHLPP1, Impedes Autophagy, and Facilitates the Survival of Thyroid Carcinoma
Yuan Shao, Wanli Ren, Hao Dai, Fangli Yang, Xiang Li, Shaoqiang Zhang, Junsong Liu, Xiaobao Yao, Qian Zhao, Xin Sun, Zhiwei Zheng, Chongwen Xu
Molecules and Cells, 2023 - HIF-1α inhibitor YC-1 suppresses triple-negative breast cancer growth and angiogenesis by targeting PlGF/VEGFR1-induced macrophage polarization
Yan Li, Meng-Zhao Zhang, Shu-Jing Zhang, Xin Sun, Can Zhou, Juan Li, Jie Liu, Jun Feng, Shao-Ying Lu, Liu Pei-Jun, Ji-Chang Wang
Biomedicine and Pharmacotherapy, 2023 - LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877–5p/WISP2 axis
Jinxiang Zhu, Hao Dai, Xiang Li, Longwei Guo, Xin Sun, Zhiwei Zheng, Chongwen Xu
Pathology Research and Practice, 2023 - Anisodamine Enhances Macrophage M2 Polarization through Suppressing G9a-Mediated Interferon Regulatory Factor 4 Silencing to Alleviate Lipopolysaccharide-Induced Acute Lung Injury
Yunfeng Zhang, Dingli Song, Ziyang Peng, Rui Wang, Kai Li, Hong Ren, Xin Sun, Ning Du, Shou-Ching Tang
Journal of Pharmacology and Experimental Therapeutics, 2022 - Magnetic anchoring and traction technique-assisted thoracoscopic esophagectomy: Report of three cases
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2022 - The role of magnetic anchoring and traction technique in thoracoscopic lymphadenectomy along the left recurrent laryngeal nerve
Junke Fu, Yunhao Li, Ziwei Wang, Yuan Cheng, Nanzheng Chen, Xin Sun, Boxiang Zhang, Ziyang Peng, Wenwen Chen, Rongkai Qian, Aihua Shi, Xiaopeng Yan, Haohua Wang, Feng Ma, Yi Lv, Yong Zhang
Surgical Endoscopy, 2022 - Evaluation of tyrosine kinase inhibitors combined with antiprogrammed cell death protein 1 antibody in tyrosine kinase inhibitor-responsive patients with microsatellite stable/proficient mismatch repair metastatic colorectal adenocarcinoma: protocol for open-label, single-arm trial
Qian Dong, Yanwen Diao, Xin Sun, Yang Zhou, Jialing Ran, Jingdong Zhang
BMJ Open, 2022 - Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner
Kai Li, Shan Gao, Lei Ma, Ye Sun, Zi-Yang Peng, Jie Wu, Ning Du, Hong Ren, Shou-Ching Tang, Xin Sun
Frontiers in Oncology, 2022 - LINC00891 regulated by miR-128-3p/GATA2 axis impedes lung cancer cell proliferation, invasion and EMT by inhibiting RhoA pathway
Yunfeng Zhang, Dingli Song, Ziyang Peng, Rui Wang, Kai Li, Hong Ren, Xin Sun, Ning Du, Shou-Ching Tang
Acta Biochimica Et Biophysica Sinica, 2022 - Stem signatures associating SOX2 antibody helps to define diagnosis and prognosis prediction with esophageal cancer
Zi-Yang Peng, Qing-Shi Wang, Kai Li, Si-Si Chen, Xiang Li, Guo-Dong Xiao, Shou-Ching Tang, Hong Ren, Zhe Wang, Xin Sun
Annals of Medicine, 2022 - The immunotherapy candidate TNFSF4 may help the induction of a promising immunological response in breast carcinomas
Kai Li, Lei Ma, Ye Sun, Xiang Li, Hong Ren, Shou-Ching Tang, Xin Sun
Scientific Reports, 2021 - M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way
Kai Li, Zi-Yang Peng, Shan Gao, Qing-Shi Wang, Rui Wang, Xiang Li, Guo-Dong Xiao, Jing Zhang, Hong Ren, Shou-Ching Tang, Xin Sun
Journal of Experimental and Clinical Cancer Research, 2021 - Effectiveness of neoadjuvant chemotherapy on the survival outcomes of patients with resectable non-small-cell lung cancer: A meta-analysis of randomized controlled trials
Yunfeng Zhang, Xiayun Hu, Dapeng Liu, Rui Wang, Xin Sun, Ziyang Peng, Hong Ren, Ning Du
Surgical Oncology, 2021 - Dynamic monitoring of serum specific tumor markers predicts the response to PD-1 blockade and prognosis of patients with malignant tumors
Qian Dong, Xin Sun, Yang Zhou, Yan-Wen Diao, Jia-Ling Ran, Jing-Dong Zhang
Translational Cancer Research, 2021 - Lung cancer pathogenesis and poor response to therapy were dependent on driver oncogenic mutations
Xin Sun, Kai Li, Rui Zhao, Ye Sun, Jie Xu, Zi-Yang Peng, Run-Dong Song, Hong Ren, Shou-Ching Tang
Life Sciences, 2021 - Stem signatures associated antibodies yield early diagnosis and precise prognosis predication of patients with non-small cell lung cancer
Si-Si Chen, Kai Li, Jie Wu, Zi-Yang Peng, Zhi-Dong Wang, Ji-Chang Wang, Chong-Wen Xu, Cai-lin Zhu, Bao-Cheng Li, Hong Ren, Shou-Ching Tang, Xin Sun
Journal of Cancer Research and Clinical Oncology, 2021 - OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3
Boxiang Zhang, Chengcheng Yang, Rui Wang, Jie Wu, Yunfeng Zhang, Dapeng Liu, Xin Sun, Xiang Li, Hong Ren, Sida Qin
Journal of Experimental and Clinical Cancer Research, 2020 - Predicting the Survival of Triple-Negative Breast Cancer in Different Stages: A SEER Population Based Research Referring to Clinicopathological Factors
Si-Si Chen, Shou-Ching Tang, Kai Li, Jie Wu, Xiang Li, Hong Ren, Xin Sun
Cancer Investigation, 2020 - Identification of a Novel Cancer Stemness-Associated ceRNA Axis in Lung Adenocarcinoma via Stemness Indices Analysis
Pihua Han, Haiming Yang, Xiang Li, Jie Wu, Peili Wang, Dapeng Liu, Guodong Xiao, Xin Sun, Hong Ren
Oncology Research, 2020 - Matrine Inhibitory Effect on Self-renewal and Re-sensitization of 5-FU Resistant NSCLC Stem Cells were through Let-7b dependent Downregulation of CCND1
Xiang Li, Meng Wang, Ning Du, Ting Liang, Guo-Dong Xiao, Kai Li, Ji-Chang Wang, Chong-Wen Xu, Zi-Yang Peng, Shou-Ching Tang, Xin Sun
Cell Cycle, 2020 - PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin
Qiang Ma, Jing-Tao Gu, Bo Wang, Jun Feng, Lin Yang, Xiao-Wei Kang, Peng Duan, Xin Sun, Pei-Jun Liu, Ji-Chang Wang
European Journal of Pharmacology, 2019 - FAM83A-AS1 promotes lung adenocarcinoma cell migration and invasion by targeting miR-150-5p and modifying MMP14
Guodong Xiao, Peili Wang, Xiaoqiang Zheng, Dapeng Liu, Xin Sun
Cell Cycle, 2019 - TUSC7 suppression of Notch activation through sponging MiR-146 recapitulated the asymmetric cell division in lung adenocarcinoma stem cells
Guanglin Huang, Meng Wang, Xiang Li, Jie Wu, Sisi Chen, Ning Du, Kai Li, Jichang Wang, Chongwen Xu, Hong Ren, Shou-Ching Tang, Xin Sun
Life Sciences, 2019 - Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation
Ji-Chang Wang, Guang-Yue Li, Bo Wang, Su-Xia Han, Xin Sun, Yi-Na Jiang, Yan-Wei Shen, Can Zhou, Jun Feng, Shao-Ying Lu, Jian-Lin Liu, Mao-De Wang, Pei-Jun Liu
Journal of Experimental and Clinical Cancer Research, 2019 - miR-497-5p inhibits tumor cell growth and invasion by targeting SOX5 in non–small-cell lung cancer
Gang Li, Kai Wang, Jiansheng Wang, Sida Qin, Xin Sun, Hong Ren
Journal of Cellular Biochemistry, 2019 - Appcation of detection of circulating tumor cells and exosome mir-21 in diagnosis of lung ground glass opacity
Journal of Jilin University Medicine Edition, 2019 - H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let-7c in breast cancer stem-like cells
Meng Wang, Yuan Li, Guo‐Dong Xiao, Xiao‐Qiang Zheng, Ji‐Chang Wang, Chong‐Wen Xu, Sida Qin, Hong Ren, Shou‐Ching Tang, Xin Sun
Cell Proliferation, 2019 - MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer
Yamei Pang, Jian Liu, Xiang Li, Guodong Xiao, Huangzhen Wang, Ganghua Yang, Yanbo Li, Shou‐Ching Tang, Sida Qin, Ning Du, Henggang Zhang, Dapeng Liu, Xin Sun, Hong Ren
Journal of Cellular and Molecular Medicine, 2018 - Prognostic Significance of Albumin–Globulin Score in Patients with Operable Non-Small-Cell Lung Cancer
Xiang Li, Sida Qin, Xin Sun, Dapeng Liu, Boxiang Zhang, Guodong Xiao, Hong Ren
Annals of Surgical Oncology, 2018 - SNHG6 functions as a competing endogenous RNA to regulate E2F7 expression by sponging miR-26a-5p in lung adenocarcinoma
Rui Liang, Guodong Xiao, Meng Wang, Xiang Li, Yuan Li, ZengQian Hui, Xin Sun, Sida Qin, Boxiang Zhang, Ning Du, Dapeng Liu, Hong Ren
Biomedicine and Pharmacotherapy, 2018 - Clinical study of the oxygen drive aerosol inhalation with budesonide and ambroxol in the prevention of adult post-thoracotomy pneumonia
Beijing Da Xue Xue Bao Yi Xue Ban Journal of Peking University Health Sciences, 2018 - A miR-26a/E2F7 feedback loop contributes to tamoxifen resistance in ER-positive breast cancer
Jian Liu, Xiang Li, Meng Wang, Guodong Xiao, Ganghua Yang, Huangzhen Wang, Yanbo Li, Xin Sun, Sida Qin, Ning Du, Hong Ren, Yamei Pang
International Journal of Oncology, 2018 - FBXW7 suppresses epithelial-mesenchymal transition and chemo-resistance of non-small-cell lung cancer cells by targeting snai1 for ubiquitin-dependent degradation
Guodong Xiao, Yuan Li, Meng Wang, Xiang Li, Sida Qin, Xin Sun, Rui Liang, Boxiang Zhang, Ning Du, Chongwen Xu, Hong Ren, Dapeng Liu
Cell Proliferation, 2018 - Metformin's antitumour and anti-angiogenic activities are mediated by skewing macrophage polarization
Ji‐Chang Wang, Xin Sun, Qiang Ma, Gui‐Feng Fu, Long‐Long Cong, Hong Zhang, De‐Fu Fan, Jun Feng, Shao‐Ying Lu, Jian‐Lin Liu, Guang‐Yue Li, Pei‐Jun Liu
Journal of Cellular and Molecular Medicine, 2018 - MiR-146a promotes the asymmetric division and inhibits the self-renewal ability of breast cancer stem-like cells via indirect upregulation of Let-7
Rui Liang, Yuan Li, Meng Wang, Shou-Ching Tang, Guodong Xiao, Xin Sun, Gang Li, Ning Du, Dapeng Liu, Hong Ren
Cell Cycle, 2018 - Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1α-induced pro-angiogenic factor
Ji‐Chang Wang, Xiong‐Xiong Li, Xin Sun, Guang‐Yue Li, Jing‐Lan Sun, Yuan‐Peng Ye, Long‐Long Cong, Wei‐Ming Li, Shao‐Ying Lu, Jun Feng, Pei‐Jun Liu
Cancer Science, 2018 - Breast cancer stem-like cells are sensitized to tamoxifen induction of self-renewal inhibition with enforced Let-7c dependent on Wnt blocking
Xin Sun, Chongwen Xu, Guodong Xiao, Jinying Meng, Jichang Wang, Shou‑Ching Tang, Sida Qin, Ning Du, Gang Li, Hong Ren, Dapeng Liu
International Journal of Molecular Medicine, 2018 - Retrospective observational cohort study on cosmetic outcome of using Ti-Ni memory alloy wire for intradermal suture following mastectomy in patients with breast cancer
Gang Li, Sida Qin, Xin Sun, Jiansheng Wang, Yunfeng Zhang, Jia Zhang, Jing Zhang, Shou‑Ching Tang, Hong Ren
Oncology Letters, 2018 - CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade
C Xu, G Xiao, B Zhang, M Wang, J Wang, D Liu, J Zhang, H Ren, X Sun
Gene Therapy, 2018 - The efficacy and safety of anti-PD-1/PD-L1 antibody therapy versus docetaxel for pretreated advanced NSCLC: A meta-analysis
Guanghong Huang, Xin Sun, Dapeng Liu, Yunfeng Zhang, Boxiang Zhang, Guodong Xiao, Xiang Li, Xiao Gao, Chenhao Hu, Meng Wang, Hong Ren, Sida Qin
Oncotarget, 2018 - miR-367 stimulates Wnt cascade activation through degrading FBXW7 in NSCLC stem cells
Guodong Xiao, Boxiang Zhang, Jinying Meng, Jichang Wang, Chongwen Xu, Shou-Ching Tang, Xiang Li, Jing Zhang, Rui Liang, Hong Ren, Xin Sun
Cell Cycle, 2017 - Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers
Guodong Xiao, Jinying Meng, Jing Zhang, Gang Li, Ning Du, Sida Qin, Jichang Wang, Chongwen Xu, Hong Ren, Shou-Ching Tang, Xin Sun
Cancer Investigation, 2017 - Nano Let.7b sensitization of eliminating esophageal cancer stem.like cells is dependent on blockade of Wnt activation of symmetric division
Yamei Pang, Jian Liu, Xiang Li, Yiwen Zhang, Boxiang Zhang, Jing Zhang, Ning Du, Chongwen Xu, Rui Liang, Hong Ren, Shou-Ching Tang, Xin Sun
International Journal of Oncology, 2017 - MiR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC
Guodong Xiao, Xiao Gao, Xin Sun, Chengcheng Yang, Boxiang Zhang, Ruiying Sun, Guanghong Huang, Xiang Li, Jian Liu, Ning Du, Dapeng Liu, Rui Liang, Hong Ren, Sida Qin
Oncology Reports, 2017 - Effects of rhTIMP-3 combined with DDP on growth inhibition and apoptosis of lung cancer cell A549
Journal of Xi an Jiaotong University Medical Sciences, 2017 - Suppression of hypoxia-induced excessive angiogenesis by metformin via elevating tumor blood perfusion
Ji-Chang Wang, Guang-Yue Li, Ping-Ping Li, Xin Sun, Wei-Ming Li, Yan Li, Shao-Ying Lu, Pei-Jun Liu
Oncotarget, 2017 - Augmented expression of polo-like kinase 1 indicates poor clinical outcome for breast patients: A systematic review and meta-analysis
Yunfeng Zhang, Zhibin Wu, Dapeng Liu, Meng Wang, Guodong Xiao, Peili Wang, Xin Sun, Hong Ren, Shou-Ching Tang, Ning Du
Oncotarget, 2017 - MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells
Guodong Xiao, Xiang Li, Gang Li, Boxiang Zhang, Chongwen Xu, Sida Qin, Ning Du, Jichang Wang, Shou-Ching Tang, Jing Zhang, Hong Ren, Ke Chen, Xin Sun
Oncotarget, 2017 - Analysis of risk factors for post-operative complications and prognostic predictors of disease recurrence following definitive treatment of patients with esophageal cancer from two medical centers in Northwest China
Jichang Wang, Boxiang Zhang, Jinying Meng, Guodong Xiao, Xiang Li, Gang Li, Sida Qin, Ning Du, Jia Zhang, Jing Zhang, Chongwen Xu, Shou-Ching Tang, Rui Liang, Hong Ren, Xin Sun
Experimental and Therapeutic Medicine, 2017 - Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation
Sida Qin, Boxiang Zhang, Guodong Xiao, Xin Sun, Gang Li, Guanghong Huang, Xiao Gao, Xiang Li, Huangzhen Wang, Chengcheng Yang, Hong Ren
Tumor Biology, 2016 - XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC
Sida Qin, Chengcheng Yang, Boxiang Zhang, Xiang Li, Xin Sun, Gang Li, Jing Zhang, Guodong Xiao, Xiao Gao, Guanghong Huang, Peili Wang, Hong Ren
International Journal of Oncology, 2016 - LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC
Chengcheng Yang, Huangzhen Wang, Boxiang Zhang, Yimeng Chen, Yamin Zhang, Xin Sun, Guodong Xiao, Kejun Nan, Hong Ren, Sida Qin
Journal of Experimental and Clinical Cancer Research, 2016 - The insights of Let-7 miRNAs in oncogenesis and stem cell potency
Xin Sun, Jian Liu, Chongwen Xu, Shou‐Ching Tang, Hong Ren
Journal of Cellular and Molecular Medicine, 2016 - CDH1 promoter methylation correlates with decreased gene expression and poor prognosis in patients with breast cancer
JIAN LIU, XIN SUN, SIDA QIN, HUANGZHEN WANG, NING DU, YANBO LI, YAMEI PANG, CUICUI WANG, CHONGWEN XU, HONG REN
Oncology Letters, 2016 - Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells
X Sun, C Xu, S-C Tang, J Wang, H Wang, P Wang, N Du, S Qin, G Li, S Xu, Z Tao, Dapeng Liu, H Ren
Cancer Gene Therapy, 2016 - miR-101 inhibits the proliferation and migration of breast cancer cells via downregulating the expression of DNA methyltransferase 3a
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Chinese Journal of Cellular and Molecular Immunology, 2016 - Hyperthermia induces apoptosis by targeting Survivin in esophageal cancer
SIDA QIN, CHONGWEN XU, SHUO LI, XIFANG WANG, XIN SUN, PEILI WANG, BOXIANG ZHANG, HONG REN
Oncology Reports, 2015 - Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3
SIDA QIN, CHONGWEN XU, SHUO LI, CHENGCHENG YANG, XIN SUN, XIFANG WANG, SHOU-CHING TANG, HONG REN
Molecular Medicine Reports, 2015 - DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1
Xin Sun, Shou‐Ching Tang, Chongwen Xu, Chenguang Wang, Sida Qin, Ning Du, Jian Liu, Yiwen Zhang, Xiang Li, Gang Luo, Jie Zhou, Fei Xu, Hong Ren
Journal of Cellular and Molecular Medicine, 2015 - The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a CXCL signaling module
Ke Chen, Kongming Wu, Xuanmao Jiao, Liping Wang, Xiaoming Ju, Min Wang, Gabriele Di Sante, Shaohua Xu, Qiong Wang, Kevin Li, Xin Sun, Congwen Xu, Zhiping Li, Mathew C. Casimiro, Adam Ertel, Sankar Addya, Peter A. McCue, Michael P. Lisanti, Chenguang Wang, Richard J. Davis, Graeme Mardon, Richard G. Pestell
Cancer Research, 2015 - MicroRNA-221 accelerates the proliferation of laryngeal cancer cell line Hep-2 by suppressing Apaf-1
XIN SUN, BIN LIU, XU-DONG ZHAO, LI-YIN WANG, WEN-YUE JI
Oncology Reports, 2015 - Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis
Jichang Wang, Guangyue Li, Yaochun Wang, Shouching Tang, Xin Sun, Xuefei Feng, Yan Li, Gang Bao, Pingping Li, Xiaona Mao, Maode Wang, Peijun Liu
Oncotarget, 2015 - Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells
Chongwen Xu, Xin Sun, Sida Qin, Huangzhen Wang, Zhiwei Zheng, Shaohua Xu, Gang Luo, Peng Liu, Jian Liu, Ning Du, Yunfeng Zhang, Dapeng Liu, Hong Ren
Cell Cycle, 2015 - Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration
Gabriele Di Sante, Liping Wang, Chenguang Wang, Xuanmiao Jiao, Mathew C. Casimiro, Ke Chen, Timothy G. Pestell, Ismail Yaman, Agnese Di Rocco, Xin Sun, Yoshiyuki Horio, Michael J. Powell, Xiaohong He, Michael W. McBurney, Richard G. Pestell
Molecular Endocrinology, 2015 - MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1
Xin Sun, Shiwen Jiang, Jian Liu, Huangzhen Wang, Yiwen Zhang, Shou-Ching Tang, Jichang Wang, Ning Du, Chongwen Xu, Chenguang Wang, Sida Qin, Jia Zhang, Dapeng Liu, Yunfeng Zhang, Xiaojun Li, Jiansheng Wang, Jun Dong, Xin Wang, Shaohua Xu, Zhen Tao, Fei Xu, Jie Zhou, Tao Wang, Hong Ren
Oncotarget, 2015 - MicroRNAs and cancer stem cells: the sword and the shield
X Sun, X Jiao, T G Pestell, C Fan, S Qin, E Mirabelli, H Ren, R G Pestell
Oncogene, 2014 - MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)
XIN SUN, ZHI-MING WANG, YAN SONG, XU-HUI TAI, WEN-YUE JI, HUI GU
International Journal of Oncology, 2014 - Possible carcinogenesis of tumor suppressor let-7
Xin Sun, Chong Fan, Ning Du, Hong Ren
Medical Hypotheses, 2013 - Let-7: A regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells
XIN SUN, SIDA QIN, CHONG FAN, CHONGWEN XU, NING DU, HONG REN
Oncology Reports, 2013 - Inhibition of p21-activated kinase 4 expression suppresses the proliferation of Hep-2 laryngeal carcinoma cells via activation of the ATM/Chk1/2/p53 pathway
XIN SUN, BIN LIU, JIN WANG, JUN LI, WEN-YUE JI
International Journal of Oncology, 2013 - The role of HOXA9 in human laryngeal squamous cell carcinoma
Xin Sun, Bin Liu, Wenyue Ji, Xiaolin Ma, Xinqi Wang, Hui Gu
Oncology Research, 2013 - The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma
Jin Wang, Yan Xu, Jun Li, Xin Sun, Li-Ping Wang, Wen-Yue Ji
Oral Oncology, 2012 - Angiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signaling
Hong Ren
Oncology Reports, 2012 - [Role of let-7 in maintaining characteristics of breast cancer stem cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Chinese Journal of Cellular and Molecular Immunology, 2012 - [Overexpression of Smac gene enhanced chemotherapeutic sensitivity of esophageal cancer cell line Eca109 to cisplatin].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Chinese Journal of Cellular and Molecular Immunology, 2012 - [Expression of caspase-8 in non-small cell lung cancer and its role in invasion and metastasis of lung cancer A549 cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Chinese Journal of Cellular and Molecular Immunology, 2012
RECENT SCHOLAR PUBLICATIONS
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C Wang, Y Meng, C Xi, Y Li, J Zhang, J Dong, Y Lian, S Xu, G Bai, X Sun
Journal of Materiomics 11 (5), 101050 , 2025
2025
Citations: 1 - Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signalling
G Ye, X Sun, J Li, M Pu, J Zhang
Journal of Advanced Research , 2025
2025
Citations: 14 - The tumor suppressor Parkin exerts anticancer effects through regulating mitochondrial GAPDH activity
X Sun, G Ye, J Li, L Yuan, G Bai, YJ Xu, J Zhang
Oncogene 43 (44), 3215-3226 , 2024
2024
Citations: 7 - Refining the optimal CAF cluster marker for predicting TME-dependent survival expectancy and treatment benefits in NSCLC patients
K Li, R Wang, GW Liu, ZY Peng, JC Wang, GD Xiao, SC Tang, N Du, ...
Scientific Reports 14 (1), 16766 , 2024
2024
Citations: 20 - Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway
G Ye, X Sun, J Li, Y Mai, R Gao, J Zhang
Journal of pharmaceutical analysis 14 (6), 100926 , 2024
2024
Citations: 24 - Sintilimab combined with anlotinib as first-line treatment for advanced sarcomatoid carcinoma of head and neck: a case report and literature review
L Wang, Y Huang, X Sun
Frontiers in Oncology 14, 1362160 , 2024
2024
Citations: 3 - Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer
X Sun, G Ye, J Li, H Shou, G Bai, J Zhang
Clinical and Translational Medicine 13 (10), e1457 , 2023
2023
Citations: 23 - Author correction: the immunotherapy candidate TNFSF4 May help the induction of a promising immunological response in breast carcinomas
K Li, L Ma, Y Sun, X Li, H Ren, SC Tang, X Sun
Scientific Reports 13 (1), 12450 , 2023
2023
Citations: 1 - Parkin exerts the tumor‐suppressive effect through targeting mitochondria
X Sun, G Ye, Y Mai, Y Shu, L Wang, J Zhang
Medicinal Research Reviews 43 (4), 855-871 , 2023
2023
Citations: 13 - Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
K Li, ZY Peng, R Wang, X Li, N Du, DP Liu, J Zhang, YF Zhang, L Ma, ...
Molecular cancer 22 (1), 103 , 2023
2023
Citations: 82 - HIF-1α inhibitor YC-1 suppresses triple-negative breast cancer growth and angiogenesis by targeting PlGF/VEGFR1-induced macrophage polarization
Y Li, MZ Zhang, SJ Zhang, X Sun, C Zhou, J Li, J Liu, J Feng, SY Lu, ...
Biomedicine & Pharmacotherapy 161, 114423 , 2023
2023
Citations: 38 - Stem signatures associating SOX2 antibody helps to define diagnosis and prognosis prediction with esophageal cancer
ZY Peng, QS Wang, K Li, SS Chen, X Li, GD Xiao, SC Tang, H Ren, ...
Annals of Medicine 54 (1), 921-932 , 2022
2022
Citations: 13 - A Quassinoid Diterpenoid Eurycomanone from Eurycoma longifolia Jack Exerts Anti-Cancer Effect through Autophagy Inhibition
G Ye, M Xu, Y Shu, X Sun, Y Mai, Y Hong, J Zhang, J Tian
Molecules 27 (14), 4398 , 2022
2022
Citations: 10 - Anisodamine enhances macrophage M2 polarization through suppressing G9a-mediated interferon regulatory factor 4 silencing to alleviate lipopolysaccharide-induced acute lung injury
Y Zhang, D Song, Z Peng, R Wang, K Li, H Ren, X Sun, N Du, SC Tang
The Journal of Pharmacology and Experimental Therapeutics 381 (3), 247-256 , 2022
2022
Citations: 12 - LINC00891 regulated by miR-128-3p/GATA2 axis impedes lung cancer cell proliferation, invasion and EMT by inhibiting RhoA pathway: LINC00891 impedes lung cancer progression
Y Zhang, D Song, Z Peng, R Wang, K Li, H Ren, X Sun, N Du, SC Tang
Acta biochimica et biophysica Sinica 54 (3), 378 , 2022
2022
Citations: 28 - The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
X Sun, Y Hong, Y Shu, C Wu, G Ye, H Chen, H Zhou, R Gao, J Zhang
Journal of Ginseng Research 46 (2), 266-274 , 2022
2022
Citations: 38 - Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
X Sun, Y Shu, G Ye, C Wu, M Xu, R Gao, D Huang, J Zhang
Acta Pharmaceutica Sinica B 12 (2), 838-852 , 2022
2022
Citations: 83 - Stimulation of Let-7 maturation by metformin improved the response to tyrosine kinase inhibitor therapy in an m6A dependent manner
K Li, S Gao, L Ma, Y Sun, ZY Peng, J Wu, N Du, H Ren, SC Tang, X Sun
Frontiers in Oncology 11, 731561 , 2022
2022
Citations: 27 - DHOK exerts anti-cancer effect through autophagy inhibition in colorectal cancer
Y Shu, X Sun, G Ye, M Xu, Z Wu, C Wu, S Li, J Tian, H Han, J Zhang
Frontiers in Cell and Developmental Biology 9, 760022 , 2021
2021
Citations: 6 - M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way
K Li, ZY Peng, S Gao, QS Wang, R Wang, X Li, GD Xiao, J Zhang, H Ren, ...
Journal of Experimental & Clinical Cancer Research 40 (1), 325 , 2021
2021
Citations: 53
MOST CITED SCHOLAR PUBLICATIONS
- MicroRNAs and cancer stem cells: the sword and the shield
X Sun, X Jiao, TG Pestell, C Fan, S Qin, E Mirabelli, H Ren, RG Pestell
Oncogene 33 (42), 4967-4977 , 2014
2014
Citations: 182 - Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation
JC Wang, GY Li, B Wang, SX Han, X Sun, YN Jiang, YW Shen, C Zhou, ...
Journal of Experimental & Clinical Cancer Research 38 (1), 235 , 2019
2019
Citations: 150 - Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis
J Wang, G Li, Y Wang, S Tang, X Sun, X Feng, Y Li, G Bao, P Li, X Mao, ...
Oncotarget 6 (42), 44579 , 2015
2015
Citations: 123 - Angiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signaling
N Du, J Feng, LJ Hu, X Sun, HB Sun, Y Zhao, YP Yang, H Ren
Oncology reports 27 (6), 1893-1903 , 2012
2012
Citations: 119 - Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells
X Sun, C Xu, SC Tang, J Wang, H Wang, P Wang, N Du, S Qin, G Li, S Xu, ...
Cancer Gene Therapy 23 (4), 83-89 , 2016
2016
Citations: 107 - The insights of Let‐7 miRNAs in oncogenesis and stem cell potency
X Sun, J Liu, C Xu, SC Tang, H Ren
Journal of cellular and molecular medicine 20 (9), 1779-1788 , 2016
2016
Citations: 106 - Metformin's antitumour and anti‐angiogenic activities are mediated by skewing macrophage polarization
JC Wang, X Sun, Q Ma, GF Fu, LL Cong, H Zhang, DF Fan, J Feng, SY Lu, ...
Journal of cellular and molecular medicine 22 (8), 3825-3836 , 2018
2018
Citations: 100 - SNHG6 functions as a competing endogenous RNA to regulate E2F7 expression by sponging miR-26a-5p in lung adenocarcinoma
R Liang, G Xiao, M Wang, X Li, Y Li, ZQ Hui, X Sun, S Qin, B Zhang, N Du, ...
Biomedicine & Pharmacotherapy 107, 1434-1446 , 2018
2018
Citations: 91 - CDH1 promoter methylation correlates with decreased gene expression and poor prognosis in patients with breast cancer
J Liu, X Sun, S Qin, H Wang, N Du, Y Li, Y Pang, C Wang, C Xu, H Ren
Oncology letters 11 (4), 2635-2643 , 2016
2016
Citations: 91 - MYC and DNMT 3A‐mediated DNA methylation represses micro RNA‐200b in triple negative breast cancer
Y Pang, J Liu, X Li, G Xiao, H Wang, G Yang, Y Li, SC Tang, S Qin, N Du, ...
Journal of Cellular and Molecular Medicine 22 (12), 6262-6274 , 2018
2018
Citations: 85 - Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
X Sun, Y Shu, G Ye, C Wu, M Xu, R Gao, D Huang, J Zhang
Acta Pharmaceutica Sinica B 12 (2), 838-852 , 2022
2022
Citations: 83 - Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
K Li, ZY Peng, R Wang, X Li, N Du, DP Liu, J Zhang, YF Zhang, L Ma, ...
Molecular cancer 22 (1), 103 , 2023
2023
Citations: 82 - LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC
C Yang, H Wang, B Zhang, Y Chen, Y Zhang, X Sun, G Xiao, K Nan, ...
Journal of Experimental & Clinical Cancer Research 35 (1), 158 , 2016
2016
Citations: 80 - Let-7: a regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells
X Sun, S Qin, C Fan, C Xu, N Du, H Ren
Oncology reports 29 (5), 2079-2087 , 2013
2013
Citations: 78 - Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF‐1α‐induced pro‐angiogenic factor
JC Wang, XX Li, X Sun, GY Li, JL Sun, YP Ye, LL Cong, WM Li, SY Lu, ...
Cancer Science 109 (5), 1627-1637 , 2018
2018
Citations: 74 - miR‐497‐5p inhibits tumor cell growth and invasion by targeting SOX5 in non–small‐cell lung cancer
G Li, K Wang, J Wang, S Qin, X Sun, H Ren
Journal of cellular biochemistry 120 (6), 10587-10595 , 2019
2019
Citations: 68 - FBXW 7 suppresses epithelial‐mesenchymal transition and chemo‐resistance of non‐small‐cell lung cancer cells by targeting snai1 for ubiquitin‐dependent degradation
G Xiao, Y Li, M Wang, X Li, S Qin, X Sun, R Liang, B Zhang, N Du, C Xu, ...
Cell proliferation 51 (5), e12473 , 2018
2018
Citations: 67 - FAM83A-AS1 promotes lung adenocarcinoma cell migration and invasion by targeting miR-150-5p and modifying MMP14
G Xiao, P Wang, X Zheng, D Liu, X Sun
Cell Cycle 18 (21), 2972-2985 , 2019
2019
Citations: 58 - Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells
C Xu, X Sun, S Qin, H Wang, Z Zheng, S Xu, G Luo, P Liu, J Liu, N Du, ...
Cell Cycle 14 (11), 1686-1697 , 2015
2015
Citations: 58 - M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way
K Li, ZY Peng, S Gao, QS Wang, R Wang, X Li, GD Xiao, J Zhang, H Ren, ...
Journal of Experimental & Clinical Cancer Research 40 (1), 325 , 2021
2021
Citations: 53
