RUSSOLINA BENEDETA ZINGALI

Scopus Publications

BmooMPα-I ameliorates aortic fibrosis and hypertrophy in 2K1C hypertensive rats by reducing matrix metalloproteinase-2 activity
Wictoria Farias Dias, Jorge Eduardo Chang Estrada, Stefanne de Cassia Pereira Silva, Pricila Rodrigues Gonçalves, Anderson Maciel Lima, Moises Hamoy, Russolina Benedeta Zingali, Andreimar Martins Soares, Marta Chagas Monteiro, Raquel Fernanda Gerlach, Keuri Eleuterio Rodrigues, Alejandro Ferraz Prado
Toxicon, 2026
Matrix metalloproteinase 2 (MMP-2) is the major MMP involved in hypertension and plays a central role in vascular remodeling in response to hemodynamic changes by promoting upregulation of transforming growth factor beta 1 (TGF-β1), vascular hypertrophy, fibrosis, and oxidative stress. BmooMPα-I, a metalloproteinase isolated from Bothrops moojeni venom, exhibits kininogenase activity, is capable of hydrolyzing angiotensin I, and exerts antihypertensive and cardioprotective effects. This study evaluated the effect of BmooMPα-I on MMP-2 activity and expression, TGF-β1 expression, redox balance, and vascular remodeling in the aorta of two-kidney, one-clip (2K1C) hypertensive rats. Male Wistar rats (180-200g) underwent 2K1C surgery, and Sham animals underwent the same procedure without the arterial clip. After two weeks, animals were divided into four groups: Sham vehicle (saline), Sham BmooMPα-I 1 μg/kg, 2K1C vehicle, and 2K1C BmooMPα-I 1 μg/kg. Animals were treated daily for two weeks. A sustained increase in systolic blood pressure (SBP) was observed in 2K1C animals, accompanied by increased activity and expression of MMP-2 and TGF-β1, oxidative stress, vascular remodeling, and fibrosis in the aorta compared to Sham animals (p < 0.05). After two weeks of BmooMPα-I treatment, 2K1C animals showed a significant reduction in SBP, along with decreased MMP-2 activity and expression, as well TGF-β1 levels. Additionally, BmooMPα-I reversed oxidative stress, hypertrophy, and collagen deposition in the aorta compared to the 2K1C vehicle group (p < 0.05), reaching values similar to Sham (p < 0.05). We conclude that BmooMPα-I exerts an antihypertensive effect and reduces MMP-2 activity and expression, negatively modulates TGF-β1 expression, and reverses oxidative stress, vascular remodeling, and fibrosis.
A Novel Trypsin Inhibitor With Immunomodulatory Activity From the Leaves of Cissus verticillata subsp. verticillata (L.) Nicolson & C.E. Jarvis
Luis Afonso Silveira Farias, Robson Raion de Vasconcelos Alves, Abdênego Rodrigues da Silva, Georon Ferreira de Sousa, Pollyanna Michelle da Silva, Ana Rosa Peixoto, Roberto Araújo Sá, Thâmarah de Albuquerque Lima, Russolina Benedeta Zingali, Cristiane Moutinho Lagos de Melo, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Maria Tereza dos Santos Correia
Chemistry and Biodiversity, 2025
In this study, we purified and characterized a trypsin inhibitor (CvLTI) from the leaves of Cissus verticillata subsp. verticillata. CvLTI was isolated using a trypsin‐agarose column and evaluated for stability towards heating (30°C– 100°C) and incubation at different pH values (2.0–10.0). Furthermore, CvLTI was investigated for antibacterial activity against phytopathogens, hemolytic activity as well as cytotoxicity and immunomodulatory effects on peripheral blood mononuclear cells (PBMCs). CvLTI (14.3 kDa, pI 5.3) showed sequence similarities with an endochitinase and showed a trypsin inhibitory activity thermostable and higher at acidic pH. The inhibitor exerted bacteriostatic effects on Pectobacterium isolates (minimum inhibitory concentration: 462 µg/mL). CvLTI showed hemolytic activity with an EC50 of 33 µg/mL. CvLTI (12.5 and 25.0 µg/mL) induced the release of cytokines interleukin (IL)‐4, IL‐6, IL‐10 and tumor necrosis factor‐α by PBMCs. These data will drive further studies on the toxicity, antitumor, and anti‐inflammatory potentials of safe doses of CvLTI.
Surface hydrophobic clusters modulate the folding stability and molecular recognition of the disintegrin jarastatin
Ariana A. Vasconcelos, Russolina B. Zingali, Fabio C.L. Almeida
Journal of Biological Chemistry, 2025
Disintegrins are cysteine-rich proteins found in snake venoms. These proteins selectively bind to integrins, which play a key role in the regulation of many physiopathological processes. They are coreless proteins that display almost all hydrophobic residues on the protein surface. The exposed hydrophobic residues form surface clusters stabilized by the interaction with the hydrophilic residues in the vicinity and the hydration shell. In the present work, we aimed to determine the stability of surface hydrophobic clusters (SHCs) and their role in protein folding and biological activity. We used urea denaturation curves followed by 1 H and 15 N chemical shifts to determine the free energy of unfolding (ΔG F-U ) and CLEANEX experiments to measure the water exchange rates of the surface amides (k ex ). The amides with higher local stability and protection from water exchange are those near or at the SHCs, which form a hydrophobic face. SHCs act as foldons, guiding oxidative folding and contributing to the formation of the disulfide bond framework, which is essential for establishing the concave shape and, ultimately, the binding cleft. On the opposite side of the protein are the residues with lower local stability and amides that exchange fast with water. This face coincides with the binding cleft of the protein to the αVβ3 integrin. Taken together, the present work established a correlation between protein hydration and the binding surface.
Bothrops jararacussu Venom Inactivated by High Hydrostatic Pressure Enhances the Immunogenicity Response in Horses and Triggers Unexpected Cross-Reactivity with Other Snake Venoms
Ricardo Teixeira-Araujo, Marisa Carvalho Suarez, Carlos Correa-Netto, Luis Eduardo Ribeiro da Cunha, Debora Foguel, Russolina Benedeta Zingali
Toxins, 2025
High hydrostatic pressure (HHP) has been used for viral inactivation to facilitate vaccine development when immunogenicity is maintained or even increased. In this work, we used HHP to inactivate Bothrops jararacussu venom. Our protocol promotes the loss of or decrease in many biological activities in venom. Horses were immunized with pressurized venom, and in contrast to native venom, this procedure does not induce any damage to animals. Furthermore, the serum obtained with pressurized venom efficiently neutralized all biological activities of B. jararacussu venom. Antibody titrations were higher in serum produced with pressurized venom compared to that produced by native venom, and this antivenom was not only effective against the venom of B. jararacussu but against the venom of other species and genera. In conclusion, our data show a new technique for producing hyperimmune serum using venom inactivated by HHP, and this method is associated with a reduction in toxic effects in immunized animals and higher potency.
Antioxidant Capacity and Angiotensin-I Converting Enzyme (ACE)-Inhibitory Activities of Peptide Fractions Obtained from Triggerfish (Balistes capriscus) Co-products
Monique Lopes Ribeiro, Anna Clara da Silva Kefner, Ana Lúcia de Oliveira Carvalho, Augusto Vieira Magalhães, Russolina Benedeta Zingali, Maria Aparecida Cicilini, Alexandre Martins Costa Santos
Food and Bioprocess Technology, 2025
Embryos extract from germinated yellow soybean (Glycine max [L.] Merrill) inhibits promastigotes form of Leishmania amazonensis
P. M. Pedrote, D. M. D. Bouts, C. L. A. Passos, J. D. Inácio, L.F.O. Gervazoni, R. Zingali, M. S. Almeida, K. M. S. Cabral, C. Follmer, E. E. Almeida-Amaral, E. Fialho
Brazilian Journal of Biology, 2025
We investigated the effect of extracts of the germinated seeds of yellow soybean cultivar BRS 258 (Glycine max [L.] Merrill) against Leishmania amazonensis promastigotes. The yellow soybean embryos extract (YSEE) was fractionated on a Sephacryl S-100 gel filtration column coupled to AKTA. Then, the fractions were applied on a 1D SDS-PAGE gels and analyzed using a Micromass ESI-Q-ToF mass spectrometer coupled to a NanoUPLC. The anti-Leishmania properties of the soybean and the Jack bean (Canavalia ensiformis) urease were evaluated by measuring promastigotes mitochondrial activity using the MTT method. The YSEE reduced significantly L. amazonensis promastigotes cell viability (94.9%) and this inhibition can be related to an embryo-specific urease. We suggest that this enzyme was able to reduce the cell viability of L. amazonensis, since an anti-Leishmania activity was confirmed with an isolated urease of the legume Jack bean. The results suggest a possible relationship of soybean embryos with urease and leishmanicidal activities. Up to now, no data were found in the literature that demonstrates an anti-Leishmaniaactivity from an embryo-specific urease of soybean.
Intramuscular injection of Bothrops jararaca venom provoked acute kidney injury (AKI): Underpinned by impaired renal filtration, Na+ handling, and tissue damage
Taissa Nunes Guerrero, Mayara Amorim Romanelli, Dayene Santos Gomes, Russolina Benedeta Zingali, Lucienne da Silva Lara
Toxicon, 2024
Cutaneous glands of the striped toad, Rhinella crucifer (Wied-Neuwied, 1821) (Amphibia: Bufonidae): Histological study and bioactivities of glandular secretions
Géssica Gomes Barbosa, Tulíbia Laurindo Silva, Ana Patrícia Silva de Oliveira, Thâmarah de Albuquerque Lima, Pollyanna Michelle da Silva, Carlos José Correia de Santana, Jeymesson Raphael Cardoso Vieira, Dyeime Ribeiro de Sousa, Francisco Assis Leite Souza, Rafael Pereira, Russolina Benedeta Zingali, Romero Marcos Pedrosa Brandão Costa, Patrícia Maria Guedes Paiva, Gilberto Gonçalves Rodrigues, Mariana S. Castro, Thiago Henrique Napoleão
Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, 2024
Dengue virus non-structural protein 3 inhibits mitochondrial respiration by impairing complex I function
Bruna G. Sousa, Nathane C. Mebus-Antunes, Lorena O. Fernandes-Siqueira, Marjolly B. Caruso, Georgia N. Saraiva, Clara F. Carvalho, Thais C. Neves-Martins, Antonio Galina, Russolina B. Zingali, Julianna D. Zeidler, Andrea T. Da Poian
Msphere, 2024
Dengue virus (DENV) infection is known to affect host cell metabolism, but the molecular players involved are still poorly known. Using a proteomics approach, we identified six DENV proteins associated with mitochondria isolated from infected hepatocytes, and most of the peptides identified were from NS3. We also found an at least twofold decrease of several electron transport system (ETS) host proteins. Thus, we investigated whether NS3 could modulate the ETS function by incubating recombinant DENV NS3 constructs in mitochondria isolated from mouse liver. We found that NS3pro (NS3 protease domain), but not the correspondent catalytically inactive mutant (NS3proS135A), impairs complex I (CI)-dependent NADH:ubiquinone oxidoreductase activity, but not the activities of complexes II, III, IV, or V. Accordingly, using high-resolution respirometry, we found that both NS3pro and full-length NS3 decrease the respiratory rates associated with malate/pyruvate oxidation in mitochondria. The NS3-induced impairment in mitochondrial respiration occurs without altering either leak respiration or mitochondria’s capacity to maintain membrane potential, suggesting that NS3 does not deeply affect mitochondrial integrity. Remarkably, CI activity is also inhibited in DENV-infected cells, supporting that the NS3 effects observed in isolated mitochondria may be relevant in the context of the infection. Finally, in silico analyses revealed the presence of potential NS3 cleavage sites in 17 subunits of mouse CI and 16 subunits of human CI, most of them located on the CI surface, suggesting that CI is prone to undergo proteolysis by NS3. Our findings suggest that DENV NS3 can modulate mitochondrial bioenergetics by directly affecting CI function. IMPORTANCE Dengue virus (DENV) infection is a major public health problem worldwide, affecting about 400 million people yearly. Despite its importance, many molecular aspects of dengue pathogenesis remain poorly known. For several years, our group has been investigating DENV-induced metabolic alterations in the host cells, focusing on the bioenergetics of mitochondrial respiration. The results of the present study reveal that the DENV non-structural protein 3 (NS3) is found in the mitochondria of infected cells, impairing mitochondrial respiration by directly targeting one of the components of the electron transport system, the respiratory complex I (CI). NS3 acts as the viral protease during the DENV replication cycle, and its proteolytic activity seems necessary for inhibiting CI function. Our findings uncover new nuances of DENV-induced metabolic alterations, highlighting NS3 as an important player in the modulation of mitochondria function during infection.
Anti-hemostatic, antithrombotic, and chemical profiles of a curly-leaf variety of Petroselinum crispum (Apiaceae), a food and medicinal aromatic herb
Alessandra Lyra Guedes, Livia Marques Casanova, Mariana Neubarth Coelho, Flávia Serra Frattani, Sônia Soares Costa, Russolina Benedeta Zingali
Fitoterapia, 2024
Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis
Jorge Eduardo Chang Estrada, Taissa Nunes Guerrero, Daniel Fernando Reyes-Enríquez, Erica Santos Nardy, Roseane Guimarães Ferreira, Cristian José Ruiz Calderón, Irmgardt A. Wellmann, Kaio Murilo Monteiro Espíndola, Alejandro Ferraz do Prado, Andreimar Martins Soares, Marcos Roberto de Mattos Fontes, Marta Chagas Monteiro, Russolina Benedeta Zingali
Toxins, 2024
Toward the mechanism of jarastatin (rJast) inhibition of the integrin αVβ3
Ariana A. Vasconcelos, Jorge C. Estrada, Icaro P. Caruso, Eleonora Kurtenbach, Russolina B. Zingali, Fabio C.L. Almeida
International Journal of Biological Macromolecules, 2024
When a name changes everything: taxonomy and conservation of the Atlantic bushmaster (Lachesis Daudin, 1803) (Serpentes: Viperidae: Crotalinae)
Breno Hamdan, Sandro L. Bonatto, Dennis Rödder, Victor Corrêa Seixas, Rogério Mercês Ferreira Santos, Diego José Santana, Larissa Gonçalves Machado, Jessica Matos Kleiz-Ferreira, Marco A. de Freitas, Rodrigo Castellari Gonzalez, Thabata Cavalcante, Moisés Barbosa de Souza, Cristiane Barros Régis, Daniel Silva Fernandes, Hugo Fernandes-Ferreira, Russolina Benedeta Zingali
Systematics and Biodiversity, 2024
rJararacin, a recombinant disintegrin from Bothrops jararaca venom: Exploring its effects on hemostasis and thrombosis
Victor David, Luciana Serrão Wermelinger, Flávia Serra Frattani, Antonio Gilclêr Ferreira Lima, Yasmyn Fernandes Silva Santos, Paulo Antônio de Souza Mourão, Fabio Ceneviva Lacerda Almeida, Eleonora Kurtenbach, Russolina Benedeta Zingali
Archives of Biochemistry and Biophysics, 2023
The Brazilian Atlantic Bushmaster Lachesis (Linnaeus, 1766) Mitogenome With Insights On Snake Evolution And Divergence (Serpentes: Viperidae: Crotalinae)
BRENO HAMDAN, VICTOR C. SEIXAS, GISELE L. NUNES, GUILHERME OLIVEIRA, SANDRO L. BONATTO, AMANDA VIDAL, EDER S. PIRES, RUSSOLINA B. ZINGALI
Anais Da Academia Brasileira De Ciencias, 2023
Monoclonal-Based Antivenomics Reveals Conserved Neutralizing Epitopes in Type I PLA2 Molecules from Coral Snakes
Carlos Corrêa-Netto, Marcelo A. Strauch, Marcos Monteiro-Machado, Ricardo Teixeira-Araújo, Juliana Guzzo Fonseca, Moema Leitão-Araújo, Maria Lúcia Machado-Alves, Libia Sanz, Juan J. Calvete, Paulo A. Melo, Russolina Benedeta Zingali
Toxins, 2023
BmooMPα-I, a Metalloproteinase Isolated from Bothrops moojeni Venom, Reduces Blood Pressure, Reverses Left Ventricular Remodeling and Improves Cardiac Electrical Conduction in Rats with Renovascular Hypertension
Jorge Eduardo Chang Estrada, Keuri Eleutério Rodrigues, Anderson Maciel, Cahy Manoel Bannwart, Wictória Farias Dias, Moisés Hamoy, Russolina Benedeta Zingali, Andreimar Martins Soares, Carolina Heitmann Mares Azevedo Ribeiro, Raquel Fernanda Gerlach, Marta Chagas Monteiro, Alejandro Ferraz Prado
Toxins, 2022
The recombinant disintegrin, jarastatin, inhibits platelet adhesion and endothelial cell migration
Barbara Barbosa Succar, Roberta F.G. Saldanha-Gama, Aline Sol Valle, Luciana Serrão Wermelinger, Christina Barja-Fidalgo, Eleonora Kurtenbach, Russolina Benedeta Zingali
Toxicon, 2022
Proteomic Analysis of HCC-1954 and MCF-7 Cell Lines Highlights Crosstalk between αv and β1 Integrins, E-Cadherin and HER-2
Denise de Abreu Pereira, Vanessa Sandim, Thais F. B. Fernandes, Vitor Hugo Almeida, Murilo Ramos Rocha, Ronaldo J. F. C. do Amaral, Maria Isabel D. Rossi, Dário Eluan Kalume, Russolina B. Zingali
International Journal of Molecular Sciences, 2022
Pharmacological Screening of Venoms from Five Brazilian Micrurus Species on Different Ion Channels
Jessica Matos Kleiz-Ferreira, Hans Bernaerts, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Russolina Benedeta Zingali, Jan Tytgat
International Journal of Molecular Sciences, 2022
15N, 13C, and 1H resonance assignments of Jarastatin: a disintegrin of Bothrops jararaca
Ariana Azevedo Vasconcelos, Barbara Barbosa Succar, Leonardo Bartkevihi di Piero, Eleonora Kurtenbach, Russolina Benedeta Zingali, Fabio C. L. Almeida
Biomolecular NMR Assignments, 2022
Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction
Ariana A. Vasconcelos, Jorge C. Estrada, Victor David, Luciana S. Wermelinger, Fabio C. L. Almeida, Russolina B. Zingali
Frontiers in Molecular Biosciences, 2021
Polyclonal F(ab’)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency
Luis Eduardo R. Cunha, Adilson A. Stolet, Marcelo A. Strauch, Victor A.R. Pereira, Carlos H. Dumard, Andre M.O. Gomes, Fábio L. Monteiro, Luiza M. Higa, Patrícia N.C. Souza, Juliana G. Fonseca, Francisco E. Pontes, Leonardo G.R. Meirelles, José W.M. Albuquerque, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Tulio M. Lima, Renata G.F. Alvim, Federico F. Marsili, Marcella Moreira Caldeira, Russolina B. Zingali, Guilherme A.P. de Oliveira, Thiago M.L. Souza, Alexandre S. Silva, Rodrigo Muller, Daniela del Rosário Flores Rodrigues, Luciana Jesus da Costa, Arthur Daniel R. Alves, Marcelo Alves Pinto, Andréa C. Oliveira, Herbert L.M. Guedes, Amilcar Tanuri, Leda R. Castilho, Jerson L. Silva
Iscience, 2021
Chalcones identify cTXNPx as a potential antileishmanial drug target
Douglas O. Escrivani, Rebecca L. Charlton, Marjolly B. Caruso, Gabriela A. Burle-Caldas, Maria Paula G. Borsodi, Russolina B. Zingali, Natalia Arruda-Costa, Marcos V. Palmeira-Mello, Jéssica B. de Jesus, Alessandra M. T. Souza, Bárbara Abrahim-Vieira, Stefanie Freitag-Pohl, Ehmke Pohl, Paul W. Denny, Bartira Rossi-Bergmann, Patrick G. Steel
Plos Neglected Tropical Diseases, 2021
Cellular Growth Arrest and Efflux Pumps Are Associated With Antibiotic Persisters in Streptococcus pyogenes Induced in Biofilm-Like Environments
Caroline Lopes Martini, Amada Zambrana Coronado, Maria Celeste Nunes Melo, Clarice Neffa Gobbi, Úrsula Santos Lopez, Marcos Correa de Mattos, Thais Tavares Amorim, Ana Maria Nunes Botelho, Ana Tereza Ribeiro Vasconcelos, Luiz Gonzaga Paula Almeida, Paul J. Planet, Russolina Benedeta Zingali, Agnes Marie Sá Figueiredo, Bernadete Teixeira Ferreira-Carvalho
Frontiers in Microbiology, 2021
Three-finger toxins from brazilian coral snakes: From molecular framework to insights in biological function
Jessica Matos Kleiz-Ferreira, Nuria Cirauqui, Edson Araujo Trajano, Marcius da Silva Almeida, Russolina Benedeta Zingali
Toxins, 2021
Oral treatment with a chemically characterized parsley (Petroselinum crispum var. neapolitanum Danert) aqueous extract reduces thrombi formation in rats
Flávia Serra Frattani, Mariane Assafim, Livia Marques Casanova, Jacqueline Elis de Souza, Douglas Siqueira de Almeida Chaves, Sônia Soares Costa, Russolina Benedeta Zingali
Journal of Traditional and Complementary Medicine, 2021
Quantitative proteomic analysis reveals altered enzyme expression profile in Zea mays roots during the early stages of colonization by Herbaspirillum seropedicae
Rosane de Oliveira Nunes, Giselli Domiciano Abrahão, Wilber de Sousa Alves, Jaqueline Aparecida de Oliveira, Fábio César Sousa Nogueira, Luciano Pasqualoto Canellas, Fábio Lopes Olivares, Russolina Benedeta Zingali, Márcia Regina Soares
Proteomics, 2021
Widow spiders in the New World: a review on Latrodectus Walckenaer, 1805 (Theridiidae) and latrodectism in the Americas
Marjolly Brigido Caruso, Pedro Santana Sales Lauria, Claudio Maurício Vieira de Souza, Luciana Lyra Casais-e-Silva, Russolina Benedeta Zingali
Journal of Venomous Animals and Toxins Including Tropical Diseases, 2021
Investigation of the ability of the oviposition-stimulant lectin from Moringa oleifera seeds (WSMoL) to bind with membrane proteins present in the legs of Aedes aegypti
Livia Lais de Santana Silva, Nataly Diniz de Lima Santos, Stella Cristina Cabral Silva, Thâmarah de Albuquerque Lima, Luana Cassandra Breitenbach Barroso Coelho, Russolina Benedeta Zingali, Daniela Maria do Amaral Ferraz Navarro, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva
International Journal of Biological Macromolecules, 2020
Evaluation of the Enzymatic Arsenal Secreted by Myceliophthora thermophila During Growth on Sugarcane Bagasse With a Focus on LPMOs
Maria Angela B. Grieco, Mireille Haon, Sacha Grisel, Ana Lucia de Oliveira-Carvalho, Augusto Vieira Magalhães, Russolina B. Zingali, Nei Pereira, Jean-Guy Berrin
Frontiers in Bioengineering and Biotechnology, 2020
Schinus terebinthifolia leaf lectin (SteLL) is an immunomodulatory agent by altering cytokine release by mice splenocytes
Ardilles Juan Carlos Alves dos Santos, Bárbara Rafaela da Silva Barros, Lethícia Maria de Souza Aguiar, Leydianne Leite de Siqueira Patriota, Thâmarah de Albuquerque Lima, Russolina Benedeta Zingali, Patrícia Maria Guedes Paiva, Thiago Henrique Napoleão, Cristiane Moutinho Lagos de Melo, Emmanuel Viana Pontual
3 Biotech, 2020
Polysaccharide composition of an anticoagulant fraction from the aqueous extract of Marsypianthes chamaedrys (Lamiaceae)
Mariana N. Coelho, Paulo A.G. Soares, Flávia S. Frattani, Luiza M.M. Camargo, Ana M.F. Tovar, Paula F. de Aguiar, Russolina B. Zingali, Paulo A.S. Mourão, Sônia S. Costa
International Journal of Biological Macromolecules, 2020
Protective factors in mature human milk: a look into the proteome and peptidome of adolescent mothers' breast milk
Isabele Batista Campanhon, Márcia Regina Soares da Silva, Mariana Torquato Quezado de Magalhães, Russolina Benedeta Zingali, Flávia Fioruci Bezerra, Alexandre Guedes Torres
British Journal of Nutrition, 2019
Evaluation of the effects of humic acids on maize root architecture by label-free proteomics analysis
Rosane Oliveira Nunes, Giselli Abrahão Domiciano, Wilber Sousa Alves, Ana Claudia Amaral Melo, Fábio Cesar Sousa Nogueira, Luciano Pasqualoto Canellas, Fábio Lopes Olivares, Russolina Benedeta Zingali, Márcia Regina Soares
Scientific Reports, 2019
Portulaca elatior root contains a trehalose-binding lectin with antibacterial and antifungal activities
José Dayvid Ferreira da Silva, Suéllen Pedrosa da Silva, Pollyanna Michelle da Silva, Amanda Mota Vieira, Larissa Cardoso Correa de Araújo, Thâmarah de Albuquerque Lima, Ana Patrícia Silva de Oliveira, Lidiane Vasconcelos do Nascimento Carvalho, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Irapuan Oliveira Pinheiro, Russolina Benedeta Zingali, Maria do Socorro de Mendonça Cavalcanti, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva
International Journal of Biological Macromolecules, 2019
A trypsin inhibitor from Moringa oleifera flower extract is cytotoxic to Trypanosoma cruzi with high selectivity over mammalian cells
Emmanuel V. Pontual, Divar F. Pires-Neto, Karina Fraige, Taciana M. M. Higino, Belany E. A. Carvalho, Neyla M. P. Alves, Thâmarah A. Lima, Russolina B. Zingali, Luana C. B. B. Coelho, Vanderlan S. Bolzani, Regina C. B. Q. Figueiredo, Thiago H. Napoleão, Patrícia M. G. Paiva
Natural Product Research, 2018
Pain-like behaviors and local mechanisms involved in the nociception experimentally induced by Latrodectus curacaviensis spider venom
Pedro Santana Sales Lauria, Luciana Lyra Casais-e-Silva, Renan Fernandes do Espírito-Santo, Claudio Maurício Vieira de Souza, Russolina Benedeta Zingali, Marjolly Brígido Caruso, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
Toxicology Letters, 2018
Protein Profile of Blood Monocytes is Altered in HTLV-1 Infected Patients: Implications for HAM/TSP Disease
Juliana Echevarria-Lima, Denise de Abreu Pereira, Thais Silva de Oliveira, Otávio de Melo Espíndola, Marco Antonio Lima, Ana Cláudia Celestino Leite, Vanessa Sandim, Clarissa Rodrigues Nascimento, Dario E. Kalume, Russolina B. Zingali
Scientific Reports, 2018
Recombinant and chimeric disintegrins in preclinical research
Victor David, Barbara Barbosa Succar, João Alfredo De Moraes, Roberta Ferreira Gomes Saldanha-Gama, Christina Barja-Fidalgo, Russolina Benedeta Zingali
Toxins, 2018
Binding targets of termiticidal lectins from the bark and leaf of Myracrodruon urundeuva in the gut of Nasutitermes corniger workers
Thâmarah A Lima, Leonardo P Dornelles, Ana Patrícia S Oliveira, Caio CS Guedes, Sueden O Souza, Roberto A Sá, Russolina B Zingali, Thiago H Napoleão, Patrícia MG Paiva
Pest Management Science, 2018
Purification and characterization of a protease from the visceral mass of Mytella charruana and its evaluation to obtain antimicrobial peptides
Leonardo Prezzi Dornelles, Maria de Fátima Deodato de Souza, Pollyanna Michelle da Silva, Thamara Figueiredo Procópio, Ricardo Salas Roldan Filho, Thâmarah de Albuquerque Lima, Ana Patrícia Silva de Oliveira, Russolina Benedeta Zingali, Patrícia Maria Guedes Paiva, Emmanuel Viana Pontual, Thiago Henrique Napoleão
Food Chemistry, 2018
Breast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms
Fausto G. Gomes, Vanessa Sandim, Vitor H. Almeida, Araci M.R. Rondon, Barbara B. Succar, Eugenio D. Hottz, Ana Carolina Leal, Brunno Renato F. Verçoza, Juliany Cola F. Rodrigues, Patrícia T. Bozza, Russolina B. Zingali, Robson Q. Monteiro
Thrombosis Research, 2017
The antithrombotic and haemostatic effects of LASSBio-752: a synthetic, orally active compound in an arterial and venous thrombosis model in rats
Flávia S Frattani, Lidia M Lima, Eliezer J Barreiro, Russolina B Zingali
Journal of Pharmacy and Pharmacology, 2017
The costa of trichomonads: A complex macromolecular cytoskeleton structure made of uncommon proteins
Ivone de Andrade Rosa, Marjolly Brigido Caruso, Eidy de Oliveira Santos, Luiz Gonzaga, Russolina Benedeta Zingali, Ana Tereza R de Vasconcelos, Wanderley de Souza, Marlene Benchimol
Biology of the Cell, 2017
Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: A study with crotamine
Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali, Carlos Correa-Netto
Journal of Venomous Animals and Toxins Including Tropical Diseases, 2017
Can anti-bothropstoxin-I antibodies discriminate between Bothrops jararaca and Bothrops jararacussu venoms
Ricardo Teixeira Araujo, Carlos Corrêa-Netto, Leonora Brazil-Más, Caio Raony Farina Silveira, Irene Fernandes, Russolina Benedeta Zingali
Journal of Venomous Animals and Toxins Including Tropical Diseases, 2017
Proteomic analysis of the secretome of HepG2 cells indicates differential proteolytic processing after infection with dengue virus
Marjolly B. Caruso, Monique R.O. Trugilho, Luiza M. Higa, André S. Teixeira-Ferreira, Jonas Perales, Andrea T. Da Poian, Russolina B. Zingali
Journal of Proteomics, 2017
A proteomic approach to compare saliva from individuals with and without oral leukoplakia
Danielle Resende Camisasca, Lorena da Rós Gonçalves, Márcia Regina Soares, Vanessa Sandim, Fábio César Sousa Nogueira, Carlos Henrique Saraiva Garcia, Rodrigo Santana, Silvia Paula de Oliveira, Luisa Aguirre Buexm, Paulo Antônio Silvestre de Faria, Fernando Luiz Dias, Denise de Abreu Pereira, Russolina B. Zingali, Gilda Alves, Simone Queiroz Chaves Lourenço
Journal of Proteomics, 2017
Differences between renal effects of venom from two Bothrops jararaca populations from southeastern and southern Brazil
Roberta Jeane Bezerra Jorge, Antônio Rafael Coelho Jorge, Ramon Róseo Paula Pessoa Bezerra de Menezes, Clarissa Perdigão Mello, Danya Bandeira Lima, João Alison de Moraes Silveira, Natacha Teresa Queiroz Alves, Aline Diogo Marinho, Rafael Matos Ximenes, Carlos Corrêa-Netto, Larissa Gonçalves Machado, Russolina Benedeta Zingali, Alice Maria Costa Martins, Helena Serra Azul Monteiro
Toxicon, 2017
The juicy sarcotesta of Punica granatum contains a lectin that affects growth, survival as well as adherence and invasive capacities of human pathogenic bacteria
Pollyanna M. Silva, Thiago H. Napoleão, Laysa C.P.B.B. Silva, Deborah T.O. Fortes, Thâmarah A. Lima, Russolina B. Zingali, Emmanuel V. Pontual, Janete M. Araújo, Paloma L. Medeiros, Claudio G. Rodrigues, Francis S. Gomes, Patrícia M.G. Paiva
Journal of Functional Foods, 2016
Evaluation of antimicrobial, cytotoxic, and hemolytic activities from venom of the spider Lasiodora sp.
Felipe Roberto Borba Ferreira, Pollyanna Michelle da Silva, Tatiana Soares, Larissa Gonçalves Machado, Larissa Cardoso Corrêa de Araújo, Teresinha Gonçalves da Silva, Gabriela Souto Vieira de Mello, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rego, Emmanuel Viana Pontual, Russolina Benedeta Zingali, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva
Toxicon, 2016
Biotechnological value of Moringa oleifera seed cake as source of insecticidal lectin against Aedes aegypti
Ana Patrícia Silva de Oliveira, Livia Lais de Santana Silva, Thâmarah de Albuquerque Lima, Emmanuel Viana Pontual, Nataly Diniz de Lima Santos, Luana Cassandra Breitenbach Barroso Coelho, Daniela Maria do Amaral Ferraz Navarro, Russolina Benedeta Zingali, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva
Process Biochemistry, 2016
Exploiting the antithrombotic effect of the (pro)thrombin inhibitor bothrojaracin
Mariane Assafim, Flávia S. Frattani, Marcos S. Ferreira, Dione M. Silva, Robson Q. Monteiro, Russolina B. Zingali
Toxicon, 2016
Metaproteomics reveals metabolic transitions between healthy and diseased stony coral Mussismilia braziliensis
Gizele D. Garcia, Eidy de O. Santos, Gabriele V. Sousa, Russolina B. Zingali, Cristiane C. Thompson, Fabiano L. Thompson
Molecular Ecology, 2016
Differential proteomic analysis of outer membrane enriched extracts of Bacteroides fragilis grown under bile salts stress
Renata F. Boente, Heidi Pauer, Deborah N.S. Silva, Joaquim Santos Filho, Vanessa Sandim, Luis Caetano M. Antunes, Rosana Barreto Rocha Ferreira, Russolina B. Zingali, Regina M.C.P. Domingues, Leandro A. Lobo
Anaerobe, 2016
Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest
Larissa Gonçalves-Machado, Davinia Pla, Libia Sanz, Roberta Jeane B. Jorge, Moema Leitão-De-Araújo, Maria Lúcia M. Alves, Diego Janisch Alvares, Joari De Miranda, Jenifer Nowatzki, Karen de Morais-Zani, Wilson Fernandes, Anita Mitico Tanaka-Azevedo, Julián Fernández, Russolina B. Zingali, José María Gutiérrez, Carlos Corrêa-Netto, Juan J. Calvete
Journal of Proteomics, 2016
Proteomic analysis reveals differentially secreted proteins in the urine from patients with clear cell renal cell carcinoma
Vanessa Sandim, Denise de Abreu Pereira, Dário Eluan Kalume, Ana Lucia Oliveira-Carvalho, Antonio Augusto Ornellas, Marcia Regina Soares, Gilda Alves, Russolina Benedeta Zingali
Urologic Oncology Seminars and Original Investigations, 2016
Proteomics of cell-cell interactions in health and disease
Rafael S. Lindoso, Vanessa Sandim, Federica Collino, Adriana B. Carvalho, Juliana Dias, Milene R. da Costa, Russolina B. Zingali, Adalberto Vieyra
Proteomics, 2016
Ecotin: Exploring a feasible antithrombotic profile
Luciana Serrão Wermelinger, Flávia Serra Frattani, Tatiana Correa Carneiro-Lobo, Charles S. Craik, Helena Carla Castro, Russolina Benedeta Zingali
International Journal of Biological Macromolecules, 2015
Isoforms of Hsp70-binding human LDL in adult Schistosoma mansoni worms
Adriana S. A. Pereira, Marília G. S. Cavalcanti, Russolina B. Zingali, José L. Lima-Filho, Maria E. C. Chaves
Parasitology Research, 2015
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus
Leandro Koifman, Paulo Ornellas, Antonio Augusto Ornellas, Denise de Abreu Pereira, Benedeta Russolina Zingali, Silvia Maria Baeta Cavalcanti, Larissa Alves Afonso, Vanessa Sandim, Gilda Alves
International Braz J Urol, 2015
Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil
Roberta Jeane B. Jorge, Helena S.A. Monteiro, Larissa Gonçalves-Machado, Míriam C. Guarnieri, Rafael M. Ximenes, Diva M. Borges-Nojosa, Karla P. de O. Luna, Russolina B. Zingali, Carlos Corrêa-Netto, José María Gutiérrez, Libia Sanz, Juan J. Calvete, Davinia Pla
Journal of Proteomics, 2015
Functional variability of snake venom metalloproteinases: Adaptive advantages in targeting different prey and implications for human envenomation
Juliana L. Bernardoni, Leijiane F. Sousa, Luciana S. Wermelinger, Aline S. Lopes, Benedito C. Prezoto, Solange M. T. Serrano, Russolina B. Zingali, Ana M. Moura-da-Silva
Plos One, 2014
Modulation of α-enolase post-translational modifications by dengue virus: Increased secretion of the basic isoforms in infected hepatic cells
Luiza M. Higa, Bruno M. Curi, Renato S. Aguiar, Cynthia C. Cardoso, André G. De Lorenzi, Silvia L. F. Sena, Russolina B. Zingali, Andrea T. Da Poian
Plos One, 2014
Four conventional soybean [Glycine max (L.) Merrill] seeds exhibit different protein profiles as revealed by proteomic analysis
Luciana S. Gomes, Raquel Senna, Vanessa Sandim, Mário A. C. Silva-Neto, Jonas E. A. Perales, Russolina B. Zingali, Márcia R. Soares, Eliane Fialho
Journal of Agricultural and Food Chemistry, 2014
Purification and characterization of the lectin from taro (colocasia esculenta) and its effect on mouse splenocyte proliferation in vitro and in vivo
Patrícia Ribeiro Pereira, Eduardo Mere Del Aguila, Maurício Afonso Verícimo, Russolina Benedeta Zingali, Vânia Margaret Flosi Paschoalin, Joab Trajano Silva
Protein Journal, 2014
New insights on the Golgi complex of Tritrichomonas foetus
IVONE De ANDRADE ROSA, MARJOLLY BRIGIDO CARUSO, SILAS PESSINI RODRIGUES, REINALDO BARROS GERALDO, LUIZA WILGES KIST, MAURICIO REIS BOGO, LUIZ GONZAGA, ANA TEREZA R DE VASCONCELOS, JOSE ANDRES MORGADO-DÍAZ, RUSSOLINA BENEDETA ZINGALI, MARLENE BENCHIMOL
Parasitology, 2014
Molecular characterization of Rhodnius prolixus' embryonic cuticle
Paula S. Souza-Ferreira, Mônica F. Moreira, Geórgia C. Atella, Ana Lúcia Oliveira-Carvalho, Roberto Eizemberg, David Majerowicz, Ana C.A. Melo, Russolina B. Zingali, Hatisaburo Masuda
Insect Biochemistry and Molecular Biology, 2014
Crovirin, a Snake Venom Cysteine-Rich Secretory Protein (CRISP) with Promising Activity against Trypanosomes and Leishmania
Camila M. Adade, Ana Lúcia O. Carvalho, Marcelo A. Tomaz, Tatiana F. R. Costa, Joseane L. Godinho, Paulo A. Melo, Ana Paula C. A. Lima, Juliany C. F. Rodrigues, Russolina B. Zingali, Thaïs Souto-Padrón
Plos Neglected Tropical Diseases, 2014
Pyruvate decarboxylase activity is regulated by the Ser/Thr protein phosphatase Sit4p in the yeast Saccharomyces cerevisiae
Leandro José de Assis, Russolina Benedeta Zingali, Claudio Akio Masuda, Silas Pessini Rodrigues, Monica Montero-Lomelí
FEMS Yeast Research, 2013
Oral antithrombotic effects of acylhydrazone derivatives
Fl^|^aacutevia Serra Frattani, Eduardo Oliveira Coriolano, Lidia Moreira Lima, Eliezer Jesus Barreiro, Russolina Benedeta Zingali
Journal of Atherosclerosis and Thrombosis, 2013
Feather keratin hydrolysates obtained from microbial keratinases: Effect on hair fiber
Ana Lúcia Vazquez Villa, Márcia Regina Senrra Aragão, Elisabete Pereira dos Santos, Ana Maria Mazotto, Russolina B Zingali, Edilma Paraguai de Souza, Alane Beatriz Vermelho
BMC Biotechnology, 2013
The Molecular and Structural Characterization of Two Vitellogenins from the Free-Living Nematode Oscheius tipulae
Daniela P. Almenara, Joselene P. de Moura, Cristiane P. Scarabotto, Russolina B. Zingali, Carlos E. Winter
Plos One, 2013
Investigation of thrombin activity with par 1-based fluorogenic peptides
Saulo Vieira, Flavia Reis, Reinaldo Geraldo, Denis Dutra, Luiz Juliano, Maria Julianod, Julio Mignaco, Russolina Zingali
Protein and Peptide Letters, 2013
Label-free quantitative proteomics reveals differentially regulated proteins in the latex of sticky diseased Carica papaya L. plants
Silas P. Rodrigues, José A. Ventura, Clemente Aguilar, Ernesto S. Nakayasu, HyungWon Choi, Tiago J.P. Sobreira, Lilian L. Nohara, Luciana S. Wermelinger, Igor C. Almeida, Russolina B. Zingali, Patricia M.B. Fernandes
Journal of Proteomics, 2012
Keratinases and sulfide from Bacillus subtilis SLC to recycle feather waste
Sabrina Martins Lage Cedrola, Ana Cristina Nogueira de Melo, Ana Maria Mazotto, Ulysses Lins, Russolina Benedeta Zingali, Alexandre Soares Rosado, Raquel S. Peixoto, Alane Beatriz Vermelho
World Journal of Microbiology and Biotechnology, 2012
Proteomic analysis of the ventral disc of Giardia lamblia
Daniela Lourenço, Iamara da Silva Andrade, Letícia Labati Terra, Patricia Ramos Guimarães, Russolina Benedeta Zingali, Wanderley de Souza
BMC Research Notes, 2012
A new exogen anticoagulant with high selectivity to intrinsic pathway of coagulation
Regina M.S. de Araújo, Antônio F.M. Vaz, Maria E. Santos, Russolina B. Zingali, Luana C.B.B. Coelho, Patrícia M.G. Paiva, Maria Tereza S. Correia, Maria L.V. Oliva, Rodrigo S. Ferreira
Thrombosis Research, 2011
Analysis of the salivary proteome in gingivitis patients
L. da R. Gonçalves, M. R. Soares, F. C. S. Nogueira, C. H. S. Garcia, D. R. Camisasca, G. Domont, A. C. R. Feitosa, D. A. Pereira, R. B. Zingali, G. Alves
Journal of Periodontal Research, 2011
Snake venomics and venom gland transcriptomic analysis of Brazilian coral snakes, Micrurus altirostris and M. corallinus
Carlos Corrêa-Netto, Inácio de L.M. Junqueira-de-Azevedo, Débora A. Silva, Paulo L. Ho, Moema Leitão-de-Araújo, Maria Lúcia M. Alves, Libia Sanz, Débora Foguel, Russolina Benedeta Zingali, Juan J. Calvete
Journal of Proteomics, 2011
Phenolic chemical composition of Petroselinum crispum extract and its effect on haemostasis
Douglas S. A. Chaves, Flávia S. Frattani, Mariane Assafim, Ana Paula de Almeida, Russolina B. Zingali, Sônia S. Costa
Natural Product Communications, 2011
Production, purification and characterization of a thermostable β-1,3-glucanase (laminarinase) produced by moniliophthora perniciosa
Amanda R. Sena, Gildomar L.V. Júnior, Aristóteles Góes Neto, Alex G. Taranto, Carlos P. Pirovani, Júlio C.M. Cascardo, Russolina B. Zingali, Marcos A. Bezerra, Sandra A. Assis
Anais Da Academia Brasileira De Ciencias, 2011
Bothrojaracin - A potent thrombin inhibitor
Russolina B. Zingali, Ana Cristina Ferraz Nogueira
Toxins and Hemostasis from Bench to Bedside, 2011
Proteomic analysis of papaya (Carica papaya L.) displaying typical sticky disease symptoms
Silas P. Rodrigues, José A. Ventura, Clemente Aguilar, Ernesto S. Nakayasu, Igor C. Almeida, Patricia M. B. Fernandes, Russolina B. Zingali
Proteomics, 2011
Immobilized Cratylia mollis lectin: An affinity matrix to purify a soybean (Glycine max) seed protein with in vitro platelet antiaggregation and anticoagulant activities
Mariana C.C. Silva, Lucimeire A. Santana, Rosemeire A. Silva-Lucca, Amanda L.R. Lima, Joana G. Ferreira, Patrícia M.G. Paiva, Luana C.B.B. Coelho, Maria L.V. Oliva, Russolina B. Zingali, Maria T.S. Correia
Process Biochemistry, 2011
Purification, characterization and structural determination of UDP-N-acetylglucosamine pyrophosphorylase produced by Moniliophthora perniciosa
Manoelito C. Santos Junior, Priscila A. Gonçalves, Alex G. Taranto, Maria G. B. Koblitz, Aristóteles Góes-Neto, Carlos P. Pirovani, Júlio C. M. Cascardo, Sandra H. da Cruz, Russolina B. Zingali, Gonçalo A. G. Pereira, Cristiano V. Dias, Sandra A. de Assis
Journal of the Brazilian Chemical Society, 2011
Biodegradation of feather waste by extracellular keratinases and gelatinases from Bacillus spp.
Ana Maria Mazotto, Ana Cristina N. de Melo, Andrew Macrae, Alexandre Soares Rosado, Raquel Peixoto, Sabrina M. L. Cedrola, Sônia Couri, Russolina B. Zingali, Ana Lúcia V. Villa, Leon Rabinovitch, Jeane Q. Chaves, Alane B. Vermelho
World Journal of Microbiology and Biotechnology, 2011
Identificación molecular y actividad sobre sustratos cromogénicos de la venombina A del veneno de la serpiente peruana Bothrops atrox
Revista Peruana De Biologia, 2010
Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: Assessment of geographic variation and its implication on snakebite management
Johara Boldrini-França, Carlos Corrêa-Netto, Marliete M.S. Silva, Renata S. Rodrigues, Pilar De La Torre, Alicia Pérez, Andreimar M. Soares, Russolina B. Zingali, Romildo A. Nogueira, Veridiana M. Rodrigues, Libia Sanz, Juan J. Calvete
Journal of Proteomics, 2010
Comparative proteomic analysis of whole saliva from chronic periodontitis patients
Lorena Da Rós Gonçalves, Márcia Regina Soares, Fábio C.S. Nogueira, Carlos Garcia, Danielle Resende Camisasca, Gilberto Domont, Alfredo C.R. Feitosa, Denise de Abreu Pereira, Russolina B. Zingali, Gilda Alves
Journal of Proteomics, 2010
Engineering ecotin for identifying proteins with a trypsin fold
Plínio C. Sathler, Charles S. Craik, Toshihiko Takeuchi, Russolina B. Zingali, Helena C. Castro
Applied Biochemistry and Biotechnology, 2010
Secondary metabolites from vegetal origin: A potential source of antithrombotic drugs
Douglas Siqueira de Almeida Chaves, Sônia Soares Costa, Ana Paula de Almeida, Flávia Frattani, Mariane Assafim, Russolina Benedeta Zingali
Quimica Nova, 2010
Immunome and venome of Bothrops jararacussu: A proteomic approach to study the molecular immunology of snake toxins
Carlos Correa-Netto, Ricardo Teixeira-Araujo, Aniesse Silva Aguiar, Aníbal Rafael Melgarejo, Salvatore Giovanni De-Simone, Márcia Regina Soares, Debora Foguel, Russolina Benedeta Zingali
Toxicon, 2010
Keratinolytic activity of Bacillus subtilis AMR using human hair
A.M. Mazotto, S.M. Lage Cedrola, U. Lins, A.S. Rosado, K.T. Silva, J.Q. Chaves, L. Rabinovitch, R.B. Zingali, A.B. Vermelho
Letters in Applied Microbiology, 2010
Pharmacological action of tick saliva upon haemostasis and the neutralization ability of sera from repeatedly infested hosts
J. RECK, M. BERGER, F. S. MARKS, R. B. ZINGALI, C. W. CANAL, C. A. S. FERREIRA, J. A. GUIMARÃES, C. TERMIGNONI
Parasitology, 2009
The interaction of Bacteroides fragilis with components of the human fibrinolytic system
Eliane de Oliveira Ferreira, Joyce Brito de Carvalho, Rafael JosÃ© M. Peixoto, Leandro Araujo Lobo, Russolina B. Zingalli, C. Jeffrey Smith, Edson R. Rocha, Regina M.C.P. Domingues
FEMS Immunology and Medical Microbiology, 2009
Bothrops insularis venomics: A proteomic analysis supported by transcriptomic-generated sequence data
Richard H. Valente, Patrícia R. Guimarães, Magno Junqueira, Ana Gisele C. Neves-Ferreira, Márcia R. Soares, Alex Chapeaurouge, Monique R.O. Trugilho, Ileana R. León, Surza L.G. Rocha, Ana Lucia Oliveira-Carvalho, Luciana S. Wermelinger, Denis L.S. Dutra, Luciana I. Leão, Inácio L.M. Junqueira-de-Azevedo, Paulo L. Ho, Russolina B. Zingali, Jonas Perales, Gilberto B. Domont
Journal of Proteomics, 2009
Integrin inhibitors from snake venom: Exploring the relationship between the structure and activity of RGD-peptides
Luciana S. Wermelinger, Reinaldo B Geraldo, Flavia S. Frattani, Carlos R. Rodrigues, Maria A. Juliano, Helena C. Castro, Russolina B. Zingali
Archives of Biochemistry and Biophysics, 2009
Evaluation of sample preparation methods for the analysis of papaya leaf proteins through two-dimensional gel electrophoresis
Silas Pessini Rodrigues, José Aires Ventura, R. B. Zingali, P. M. B. Fernandes
Phytochemical Analysis, 2009
A TonB-dependent outer membrane protein as a Bacteroides fragilis fibronectin-binding molecule
Heidi Pauer, Eliane de Oliveira Ferreira, Joaquim dos Santos-Filho, Maristela Barbosa Portela, Russolina Benedeta Zingali, Rosangela Maria Araújo Soares, Regina Maria Cavalcanti Pilotto Domingues
FEMS Immunology and Medical Microbiology, 2009
Effect of Moringa oleifera lectin on development and mortality of Aedes aegypti larvae
Juliene S. Coelho, Nataly D.L. Santos, Thiago H. Napoleão, Francis S. Gomes, Rodrigo S. Ferreira, Russolina B. Zingali, Luana C.B.B. Coelho, Sônia P. Leite, Daniela M.A.F. Navarro, Patrícia M.G. Paiva
Chemosphere, 2009
Secretome of HepG2 cells infected with dengue virus: Implications for pathogenesis
Luiza M. Higa, Marjolly B. Caruso, Flávia Canellas, Marcia R. Soares, Ana Lúcia Oliveira-Carvalho, Donat A. Chapeaurouge, Priscila M. Almeida, Jonas Perales, Russolina B. Zingali, Andrea T. Da Poian
Biochimica Et Biophysica Acta Proteins and Proteomics, 2008
Identification and characterization of a new member of snake venom thrombin inhibitors from Bothrops insularis using a proteomic approach
Ana Lúcia Oliveira-Carvalho, Patrícia Ramos Guimarães, Paula Alvarez Abreu, Denis L.S. Dutra, Inácio L.M. Junqueira-de-Azevedo, Carlos Rangel Rodrigues, Paulo Lee Ho, Helena C. Castro, Russolina B. Zingali
Toxicon, 2008
Molecular characterization of BjussuSP-I, a new thrombin-like enzyme with procoagulant and kallikrein-like activity isolated from Bothrops jararacussu snake venom
Carolina D. Sant'Ana, Carolina P. Bernardes, Luiz Fernando M. Izidoro, Maurício V. Mazzi, Sandro G. Soares, André L. Fuly, Russolina B. Zingali, Angelo J. Magro, Antonio S.K. Braz, Marcos R.M. Fontes, Rodrigo G. Stábeli, Suely V. Sampaio, Andreimar M. Soares
Biochimie, 2008
Synthesis and anti-platelet activity of novel arylsulfonate-acylhydrazone derivatives, designed as antithrombotic candidates
Lídia M. Lima, Flávia S. Frattani, Jean L. dos Santos, Helena C. Castro, Carlos Alberto M. Fraga, Russolina B. Zingali, Eliezer J. Barreiro
European Journal of Medicinal Chemistry, 2008
Effect of RGD-disintegrins on melanoma cell growth and metastasis: Involvement of the actin cytoskeleton, FAK and c-Fos
Isabela Batista Oliva, Raphael Molinaro Coelho, Gabriel Gjorup Barcellos, Roberta Saldanha-Gama, Luciana S. Wermelinger, Cezary Marcinkiewicz, Russolina Benedeta Zingali, Christina Barja-Fidalgo
Toxicon, 2007
Suramin counteracts the haemostatic disturbances produced by Bothrops jararaca snake venom
Renato S. Fernandes, Mariane Assafim, Emerson Z. Arruda, Paulo A. Melo, Russolina B. Zingali, Robson Q. Monteiro
Toxicon, 2007
Interaction of snake-venom proteins with blood coagulation factors: Mechanisms of anticoagulant activity
Russolina B. Zingali
Toxin Reviews, 2007
Ecotin modulates thrombin activity through exosite-2 interactions
Helena C. Castro, Robson Q. Monteiro, Mariane Assafim, Natália I.V. Loureiro, Charles Craik, Russolina B. Zingali
International Journal of Biochemistry and Cell Biology, 2006
Molecular diversity of disintegrin-like domains within metalloproteinase precursors of Bothrops jararaca
Daniela A.P. Cidade, Luciana S. Wermelinger, Gisele Lôbo-Hajdu, Alberto M.R. Dávila, Cassian Bon, Russolina B. Zingali, Rodolpho M. Albano
Toxicon, 2006
Bothrops jararaca venom gland transcriptome: Analysis of the gene expression pattern
Daniela A.P. Cidade, Tatiana A. Simão, Alberto M.R. Dávila, Glauber Wagner, Inácio de L.M. Junqueira-de-Azevedo, Paulo Lee Ho, Cassian Bon, Russolina B. Zingali, Rodolpho M. Albano
Toxicon, 2006
Counteracting effect of glycyrrhizin on the hemostatic abnormalities induced by Bothrops jararaca snake venom
Mariane Assafim, Marcos S Ferreira, Flávia S Frattani, Jorge A Guimarães, Robson Q Monteiro, Russolina B Zingali
British Journal of Pharmacology, 2006
Interaction of snake-venom proteins with blood coagulation factors: Mechanisms of anticoagulant activity
Russolina B. Zingali
Toxin Reviews, 2006
Bothrojaracin, a Bothrops jararaca snake venom-derived (Pro)thrombin inhibitor, as an anti-thrombotic molecule
Russolina B. Zingali, Marcos S. Ferreira, Mariane Assafim, Flávia S. Frattani, Robson Q. Monteiro
Pathophysiology of Haemostasis and Thrombosis, 2006
Partial purification of tightly bound mitochondrial hexokinase from maize (Zea mays L.) root membranes
G.L. Rezende, C. Logullo, L. Meyer, L.B. Machado, A.L. Oliveira-Carvalho, R.B. Zingali, D. Cifuentes, A. Galina
Brazilian Journal of Medical and Biological Research, 2006
Fast analysis of low molecular mass compounds present in snake venom: Identification of ten new pyroglutamate-containing peptides
Luciana Serrão Wermelinger, Denis L. S. Dutra, Ana L. Oliveira‐Carvalho, Márcia Regina Soares, Carlos Bloch, Russolina B. Zingali
Rapid Communications in Mass Spectrometry, 2005
Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom
Márcia Regina Soares, Ana Lúcia Oliveira-Carvalho, Luciana Serrão Wermelinger, Russolina B. Zingali, Paulo Lee Ho, Inácio de L.M Junqueira-de-Azevedo, Marcelo Ribeiro Vasconcelos Diniz
Toxicon, 2005
Cloning, characterization, and structural analysis of a C-type lectin from Bothrops insularis (BiL) venom
Viviane Guimarães-Gomes, Ana Lúcia Oliveira-Carvalho, Inácio de L. M. Junqueira-de-Azevedo, Denis L. S. Dutra, Mariana Pujol-Luz, Helena C. Castro, Paulo Lee Ho, Russolina B. Zingali
Archives of Biochemistry and Biophysics, 2004
New insights into conformational and functional stability of human α-thrombin probed by high hydrostatic pressure
Luis Mauricio T. R. Lima, Russolina B. Zingali, Débora Foguel, Robson Q. Monteiro
European Journal of Biochemistry, 2004
Snake venom thrombin-like enzymes: From reptilase to now
H. C. Castro, R. B. Zingali, M. G. Albuquerque, M. Pujol-Luz, C. R. Rodrigues
Cellular and Molecular Life Sciences, 2004
RGD- and MLD-disintegrins, jarastatin and EC3, activate integrin-mediated signaling modulating the human neutrophils chemotaxis, apoptosis and IL-8 gene expression
Ana Lucia J Coelho, Marta S De Freitas, Andrea Mariano-Oliveira, Davy Carlos M Rapozo, Luis Felipe R Pinto, Stefan Niewiarowski, Russolina B Zingali, Cezary Marcinkiewicz, Christina Barja-Fidalgo
Experimental Cell Research, 2004
Preliminary in vitro studies on the Marsypianthes chamaedrys (boia-caá) extracts at fibrinoclotting induced by snake venoms
K.N.C. Castro, A.L.O. Carvalho, A.P. Almeida, D.B. Oliveira, H.R. Borba, S.S. Costa, R.B. Zingali
Toxicon, 2003
Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives
Anna C. Cunha, Juliana M. Figueiredo, Jorge L.M. Tributino, Ana L.P. Miranda, Helena C. Castro, Russolina B. Zingali, Carlos A.M. Fraga, Maria Cecı́lia B.V. de Souza, Vitor F. Ferreira, Eliezer J. Barreiro
Bioorganic and Medicinal Chemistry, 2003
Comparative evaluation of immunological and structural similarities of snake venom C-type lectin proteins
H.C. Castro, M.G.J. Lemos, C. Bon, R.B. Zingali
Toxicon, 2003
Subunit dissociation, unfolding, and inactivation of bothrojaracin, a C-type lectin-like protein from snake venom
Robson Q. Monteiro, Débora Foguel, Helena C. Castro, Russolina B. Zingali
Biochemistry, 2003
Changes in salivary nitrophorin profile during the life cycle of the blood-sucking bug Rhodnius prolixus
Mônica F. Moreira, Heloisa S.L. Coelho, Russolina B. Zingali, Pedro L. Oliveira, Hatisaburo Masuda
Insect Biochemistry and Molecular Biology, 2003
Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor
Wallace Mendes-Silva, Mariane Assafim, Bruno Ruta, Robson Q Monteiro, Jorge A Guimarães, Russolina B Zingali
Thrombosis Research, 2003
Purification and characterization of a phospholipase A2 isoenzyme isolated from Lachesis muta snake venom
André L. Fuly, Ana Luisa P. de Miranda, Russolina B. Zingali, Jorge A. Guimarães
Biochemical Pharmacology, 2002
Bothrojaracin, a proexosite I ligand, inhibits factor Va-accelerated prothrombin activation
Robson Monteiro, Russolina Zingali
Thrombosis and Haemostasis, 2002
Erratum: Characterization of bothrojaracin interaction with human prothrombin (Protein Science (2001) 10 (1897-1904))
Protein Science, 2001
Canatoxin, a toxic protein from jack beans (Canavalia ensiformis), is a variant form of urease (EC 3.5.1.5): Biological effects of urease independent of its ureolytic activity
Cristian FOLLMER, Grace B. S. BARCELLOS, Russolina B. ZINGALI, Olga L. T. MACHADO, Elias W. ALVES, Christina BARJA-FIDALGO, Jorge A. GUIMARÃES, Célia R. CARLINI
Biochemical Journal, 2001
Characterization of bothrojaracin interaction with human prothrombin
Robson Q. Monteiro, Paul E. Bock, M. Lucia Bianconi, Russolina B. Zingali
Protein Science, 2001
Structural features of a snake venom thrombin-like enzyme: Thrombin and trypsin on a single catalytic platform?
Helena C. Castro, Dione M. Silva, Charles Craik, Russolina B. Zingali
Biochimica Et Biophysica Acta Protein Structure and Molecular Enzymology, 2001
Proteolytic action of Bothrops jararaca venom upon its own constituents
J.R.F Sousa, R.Q Monteiro, H.C Castro, R.B Zingali
Toxicon, 2001
Interaction of bothrojaracin with prothrombin
Russolina B. Zingali, M. Lucia Bianconi, Robson Q. Monteiro
Haemostasis, 2001
Interaction of disintegrins with human neutrophils induces cytoskeleton reorganization, focal adhesion kinase activation, and extracellular-regulated kinase-2 nuclear translocation, interfering with the chemotactic function.
Ana Lucia J. Coelho, Marta S. De Freitas, Andrea Mariano-Oliveira, Ana L. Oliveira-Carvalho, Russolina B. Zingali, Christina Barja-Fidalgo
FASEB Journal Official Publication of the Federation of American Societies for Experimental Biology, 2001
The disintegrin-like domain of the snake venom metalloprotease alternagin inhibits α2β1 integrin-mediated cell adhesion
D.H.F. Souza, M.R.C. Iemma, L.L. Ferreira, J.P. Faria, M.L.V. Oliva, R.B. Zingali, S. Niewiarowski, H.S. Selistre-de-Araujo
Archives of Biochemistry and Biophysics, 2000
HeLp, a heme lipoprotein from the hemolymph of the cattle tick, Boophilus microplus
Clarissa M. Maya-Monteiro, Sirlei Daffre, Carlos Logullo, Flavio A. Lara, Elias W. Alves, Margareth L. Capurro, Russolina Zingali, Igor C. Almeida, Pedro L. Oliveira
Journal of Biological Chemistry, 2000
Inhibition of prothrombin activation by bothrojaracin, a C-type lectin from Bothrops jararaca venom
Robson Q. Monteiro, Russolina B. Zingali
Archives of Biochemistry and Biophysics, 2000
A heme-binding aspartic proteinase from the eggs of the hard tick Boophilus microplus
Marcos H.F. Sorgine, Carlos Logullo, Russolina B. Zingali, Gabriela O. Paiva-Silva, Luiz Juliano, Pedro L. Oliveira
Journal of Biological Chemistry, 2000
Myotoxic activity of an acidic phospholipase A2 isolated from Lachesis muta (Bushmaster) snake venom
André L Fuly, Sabrina Calil-Elias, Russolina B Zingali, Jorge A Guimarães, Paulo A Melo
Toxicon, 2000
Characterization of two novel defense peptides from pea (Pisum sativum) seeds
Marcius S. Almeida, Kátia M.S. Cabral, Russolina B. Zingali, Eleonora Kurtenbach
Archives of Biochemistry and Biophysics, 2000
Identification of Bothrojaracin-like proteins in snake venoms from Bothrops species and Lachesis muta
H.C. Castro, M. Fernandes, R.B. Zingali
Toxicon, 1999
Effects of jarastatin, a novel snake venom disintegrin, on neutrophil migration and actin cytoskeleton dynamics
Ana Lucia J. Coelho, Marta S. de Freitas, Ana Lucia Oliveira-Carvalho, Vivaldo Moura-Neto, Russolina B. Zingali, Christina Barja-Fidalgo
Experimental Cell Research, 1999
Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II
Robson Q. Monteiro, Jurema G. Rapôso, Anne Wisner, Jorge A Guimarães, Cassian Bon, Russolina B. Zingali
Biochemical and Biophysical Research Communications, 1999
Bothroalternin, a thrombin inhibitor from the venom of Bothrops alternatus
H.C Castro, D.L.S Dutra, A.L Oliveira-Carvalho, R.B Zingali
Toxicon, 1998
Isolation and properties of a new kallikrein inhibitor from Tityus serrulatus venom
L. A. F. Ferreira, R. Zingalli, G. Habermehl, I. Lebrun
Journal of Protein Chemistry, 1998
Bothrops sp. snake venoms: Comparison of some biochemical and physicochemical properties and interference in platelet functions
Ivo M.B Francischetti, Helena C Castro, Russolina B Zingali, Célia R Carlini, Jorge A Guimarães
Comparative Biochemistry and Physiology C Pharmacology Toxicology and Endocrinology, 1998
Variability of bothrojaracin isoforms and other venom principles in individual jararaca (Bothrops jararaca) snakes maintained under seasonally invariant conditions
Robson Q. Monteiro, Norma Yamanouye, Célia R. Carlini, Jorge A. Guimarães, Cassian Bon, Russolina B. Zingali
Toxicon, 1998
Bothrops jararaca snakes produce several bothrojaracin isoforms following an individual pattern
Robson Q. Monteiro, Denis L.S. Dutra, Olga L.T. Machado, Célia R. Carlini, Jorge A. Guimarães, Cassian Bon, Russolina B. Zingali
Comparative Biochemistry and Physiology B Biochemistry and Molecular Biology, 1998
Isolation, characterization and biological properties of two kinin-like peptides (peptide-S and peptide-R) from Scaptocosa raptoria venom
L.A.F Ferreira, S.M Lucas, E.W Alves, V.V Hermann, A.P Reichl, G Habermehl, R.B Zingali
Toxicon, 1998
Isolation of an aspartic proteinase precursor from the egg of a hard tick, Boophilus microplus
C. LOGULLO, I. DA SILVA VAZ, M. H. F. SORGINE, G. O. PAIVA-SILVA, F. S. FARIA, R. B. ZINGALI, M. F. R. DE LIMA, L. ABREU, E. FIALHO OLIVEIRA, E. W. ALVES, H. MASUDA, J. C. GONZALES, A. MASUDA, P. L. OLIVEIRA
Parasitology, 1998
Distinct Bothrojaracin isoforms produced by individual jararaca (Bothrops jararaca) snakes
Robson Q. Monteiro, Célia R. Carlini, Jorge A. Guimarães, Cassian Bon, Russolina B. Zingali
Toxicon, 1997
Molecular cloning and expression of bothrojaracin, a potent thrombin inhibitor from snake venom
Véronique Arocas, Helena C. Castro, Russolina B. Zingalf, Marie‐Claude Guillin, Marline Jandrot‐Perrus, Cassian Bon, Anne Wisner
European Journal of Biochemistry, 1997
Isolation of a calcium-binding phosphoprotein from the oocytes and hemolymph of the blood-sucking insect Rhodnius prolixus
Mário A.C. Silva-Neto, Geórgia C. Atella, Eliane Fialho, Márcia C. Paes, Russolina B. Zingali, Jorge H. Petretski, Elias W. Alves, Hatisaburo Masuda
Journal of Biological Chemistry, 1996
Bothrojaracin: A potent two-site-directed thrombin inhibitor
Véronique Arocas, Russolina B. Zingali, Marie-Claude Guillin, Cassian Bon, Martine Jandrot-Perrus
Biochemistry, 1996
Cerastocytin, a new thrombin-like platelet activator from the venom of the Tunisian viper Cerastes cerastes
Naziha Marrakchi, Russolina B. Zingali, Habib Karoui, Cassian Bon, Mohamed El Ayeb
Bba General Subjects, 1995
Purification, physicochemical characterization and N-terminal-amino acid sequence of a phospholipase A2 from Bothrops jararaca venom.
Brazilian Journal of Medical and Biological Research Revista Brasileira De Pesquisas Medicas E Biologicas Sociedade Brasileira De Biofisica Et Al, 1993
Bothrojaracin, a New Thrombin Inhibitor Isolated from Bothrops jararaca Venom: Characterization and Mechanism of Thrombin Inhibition
Russolina B. Zingali, Martine Jandrot-Perrus, Marie Claude Guillin, Cassian Bon
Biochemistry, 1993
Partial purification and some physicochemical properties of phospholipases A2 from the venom of the bushmaster snake (Lachesis muta).
Brazilian Journal of Medical and Biological Research Revista Brasileira De Pesquisas Medicas E Biologicas Sociedade Brasileira De Biofisica Et Al, 1993
Bothrops Jaraca snake venom: Effects on platelet aggregation
Russolina B. Zingali, Gélia R. Carlini, Ivo M. Francischetti, Jorge A. Gulmarães
Thrombosis Research, 1990
Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca)
Martha M. Tanizaki, Russolina B. Zingali, Hiroshi Kawazaki, Shinobu Imajoh, Sunao Yamazaki, Koichi Suzuki
Toxicon, 1989
Biochemical and pharmacological screening of snake (Bothrops) venoms: Characterization of components acting on blood coagulation and platelet aggregation
Brazilian Journal of Medical and Biological Research, 1988

RUSSOLINA BENEDETA ZINGALI

EDUCATION

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications