The Association Between Helicobacter pylori Infection and Eosinophilic Esophagitis: Systematic Review and Meta-Analysis Lucía Gutiérrez‐Ramírez, Sandra L. Garcia‐Dionisio, Sara Feo‐Ortega, Jesús González‐Cervera, Antonio Tejera‐Muñoz, Alfredo J. Lucendo, Ángel Arias Helicobacter, 2025 BackgroundExposure to Helicobacter pylori (H. pylori) has been associated with reduced odds of eosinophilic esophagitis (EoE).AimsTo conduct a systematic review and meta‐analysis of epidemiological studies in order to quantify the association between H. pylori infection and EoE, and to assess the certainty of the evidence linking both conditions.MethodsA comprehensive literature search was conducted in MEDLINE/PUBMED, EMBASE, and SCOPUS databases (up to September 2024) to identify observational epidemiological studies that assessed the association between objectively measured H. pylori infection and EoE. The risk of study bias was assessed structurally using the ROBINS‐E tool. Data were pooled using a random‐effects meta‐analysis. The certainty of the evidence was assessed using the GRADE approach.ResultsSixteen studies comprising 30,650 patients and 291,908 controls were included. Exposure to H. pylori was associated with a significant reduction in the odds of EoE (pooled odds ratio [OR] 0.56; 95% CI, 0.46–0.70; I2 50%) [low‐certainty evidence]. The protective effect of H. pylori was stronger in case–control studies (OR 0.49; 95% CI, 0.35–0.69) than in cohort studies (OR 0.76; 95% CI, 0.58–0.98) and was statistically significant in retrospective studies (OR 0.57; 95% CI, 0.45–0.72) and studies with high or very high risk of bias (OR 0.52; 95% CI, 0.42–0.64), but not in prospective studies (OR 0.56; 95% CI, 0.27–1.18) or those with moderate to low risk of bias (OR, 0.91; 95% CI, 0.69–1.21).ConclusionsThe association between H. pylori and EoE is mainly supported by retrospective studies with a high risk of bias. Further well‐designed studies are needed.Trial RegistrationPROSPERO number: CRD42024586653
Efficacy of Dietary Therapy for Eosinophilic Esophagitis in Children and Adults: An Updated Systematic Review and Meta-Analysis Ángel Arias, Antonio Tejera-Muñoz, Lucía Gutiérrez-Ramírez, Javier Molina-Infante, Alfredo J. Lucendo Nutrients, 2024 Background: Several dietary approaches have been used to induce remission in patients with eosinophilic esophagitis (EoE), yielding varied results. Methods: We searched the MEDLINE, EMBASE, and Scopus databases up to May 2024 to identify studies including dietary interventions for EoE used as monotherapy. Summary estimates with 95% CIs for achieving <15 eosinophils/HPF were calculated for each approach. Fixed or random effects models were used depending on heterogeneity (I2); publication bias risks were assessed using funnel plot analyses. Subgroup analyses results were compared using meta-regression. Results: Forty-three studies with 2825 patients were included in quantitative summaries. The overall rate of histologic remission was 60.6% (95% CI, 54.6–66.5%). Effectiveness rates were 94.5% (95% CI, 92.3–96.4%) for elemental diets, 63.9% (95% CI, 58.5–69.2%) for six-food elimination diets, 54.7% (95% CI, 45.7–63.6%) for four-food elimination diets, 44.3% (95% CI, 36.1–52.8%) for two-food elimination diets, 46.4% (95% CI, 40–52.9%) for one-food elimination diets, and 39.5% (95% CI, 30.3–49.2%) for allergy testing-directed food elimination diets. Overall, superior efficacy was noted in children than in adults and in retrospective compared to prospective studies. Conclusion: Diet therapy remains an effective therapeutic asset for pediatric and adult patients with EoE, with increasing efficacy noted as the levels of dietary restriction increase.
Survey to know the perception of sexual education in adolescents Revista Espanola De Salud Publica, 2024
Systematic Review and Meta-Analysis: Prevalence of Non-Alcoholic Fatty Liver Disease and Liver Fibrosis in Patients with Inflammatory Bowel Disease Pilar Navarro, Lucía Gutiérrez-Ramírez, Antonio Tejera-Muñoz, Ángel Arias, Alfredo J. Lucendo Nutrients, 2023 Background: Non-alcoholic fatty liver disease (NAFLD) is a common concomitant condition in patients with inflammatory bowel disease (IBD). We aim to assess the magnitude of this association. Methods: We searched MEDLINE, EMBASE and Scopus libraries for the period up to February 2023 to identify studies reporting cohorts of IBD patients in which NALFLD was evaluated. Results: Eighty-nine studies were analyzed. The overall prevalence of NAFLD was 24.4% (95%CI, 19.3–29.8) in IBD, 20.2% (18.3–22.3) in Crohn’s disease and 18.5% (16.4–20.8) for ulcerative colitis. Higher prevalence was found in male compared to female patients, in full papers compared to abstracts, and in cross-sectional studies compared to prospective and retrospective ones. The prevalence of NAFLD in IBD has increased in studies published from 2015 onwards: 23.2% (21.5–24.9) vs. 17.8% (13.2–22.9). Diagnostic methods for NAFLD determined prevalence figures, being highest in patients assessed by controlled attenuation parameter (38.8%; 33.1–44.7) compared to ultrasonography (28.5%; 23.1–34.2) or other methods. The overall prevalence of fibrosis was 16.7% (12.2–21.7) but varied greatly according to the measurement method. Conclusion: One-quarter of patients with IBD might present with NAFLD worldwide. This proportion was higher in recent studies and in those that used current diagnostic methods.
RECENT SCHOLAR PUBLICATIONS
Impacto del ayuno intermitente en pacientes con diabetes mellitus tipo 1 J de la Calle Rodríguez, MCG Cano, C Fernández, S García, ÁA Arias, ... Actas científicas mancha centro (ACMC) 4 (1), 5-32 , 2026 2026
Proton pump inhibitors for inducing and maintaining remission in eosinophilic esophagitis: an updated systematic review and meta-analysis AJ Lucendo, L Gutiérrez-Ramírez, A Tejera-Muñoz, J Molina-Infante, ... Clinical Gastroenterology and Hepatology , 2025 2025 Citations: 22
The Association Between Helicobacter pylori Infection and Eosinophilic Esophagitis: Systematic Review and Meta‐Analysis L Gutiérrez‐Ramírez, SL Garcia‐Dionisio, S Feo‐Ortega, ... Helicobacter 30 (2), e70038 , 2025 2025 Citations: 6
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P-261-IMPACTO DE LAS TÉCNICAS DE RECONSTRUCCIÓN TRAS DUODENOPANCREATECTOMÍA EN EL RETRASO DEL VACIAMIENTO GÁSTRICO. REVISIÓN SISTEMÁTICA Y METANÁLISIS DE RED CV Cristina, GR Lucía, MR Antonio, AA Ángel, F ELENA, SP Nuria, ... Cirugía Española 102, 480-481 , 2024 2024
Efficacy of dietary therapy for eosinophilic esophagitis in children and adults: an updated systematic review and meta-analysis Á Arias, A Tejera-Muñoz, L Gutiérrez-Ramírez, J Molina-Infante, ... Nutrients 16 (14), 2231 , 2024 2024 Citations: 38
Impact of an educational intervention about healthy lifestyles in teenagers JC Medrano-Sánchez, C Vela-Meco, L Gutiérrez-Ramírez, Á Arias-Arias, ... Medicina de Familia. SEMERGEN 50 (5), 102191 , 2024 2024 Citations: 7
Encuesta para conocer la percepción sobre la educación sexual en adolescentes: e202402005 IM Velasco-Gijón, A Polo-Oliver, L Gutiérrez-Ramírez, Á Arias-Arias, ... Revista Española de Salud Pública 98, 16 páginas-16 páginas , 2024 2024 Citations: 1
Survey to know the perception of sexual education in adolescents IM Velasco-Gijón, A Polo-Oliver, L Gutiérrez-Ramírez, Á Arias-Arias, ... Revista Española de Salud Pública 98, e202402005 , 2024 2024
P-080-RESULTADOS COMUNICADOS POR EL PACIENTE TRAS CIRUGÍA BARIÁTRICA TENDENCIA EN LA UTILIZACIÓN DE INSTRUMENTOS DE MEDICIÓN. REVISIÓN SISTEMÁTICA GR DE LA SERNA, MR ANTONIO, GR LUCÍA, CT JAVIER, ... Cirugía Española 102, 60-61 , 2024 2024
Impact of an educational intervention about healthy lifestyles in teenagers:(Pag.-e 102191) JCM Sánchez, CV Meco, LG Ramírez, ÁA Arias, AT Muñoz Semergen: revista española de medicina de familia, 6-6 , 2024 2024
O-218-UTILIDAD DE LA REALIDAD VIRTUAL INMERSIVA EN LA REDUCCIÓN DE LA ANSIEDAD PREOPERATORIA. REVISIÓN SISTEMÁTICA F ELENA, MR ANTONIO, GR LUCÍA, SP NURIA, MR ESTHER, ... Cirugía Española 102, 620-621 , 2024 2024
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Producción científica del Hospital General La Mancha Centro.: Análisis bibliométrico histórico LG Ramírez, ÁA Arias, AT Muñoz Actas científicas mancha centro (ACMC) 2 (2), 6-17 , 2024 2024 Citations: 2
Systematic review and meta-analysis: prevalence of non-alcoholic fatty liver disease and liver fibrosis in patients with inflammatory bowel disease P Navarro, L Gutierrez-Ramirez, A Tejera-Munoz, A Arias, AJ Lucendo Nutrients 15 (21), 4507 , 2023 2023 Citations: 30
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MOST CITED SCHOLAR PUBLICATIONS
Efficacy of dietary therapy for eosinophilic esophagitis in children and adults: an updated systematic review and meta-analysis Á Arias, A Tejera-Muñoz, L Gutiérrez-Ramírez, J Molina-Infante, ... Nutrients 16 (14), 2231 , 2024 2024 Citations: 38
Systematic review and meta-analysis: prevalence of non-alcoholic fatty liver disease and liver fibrosis in patients with inflammatory bowel disease P Navarro, L Gutierrez-Ramirez, A Tejera-Munoz, A Arias, AJ Lucendo Nutrients 15 (21), 4507 , 2023 2023 Citations: 30
Proton pump inhibitors for inducing and maintaining remission in eosinophilic esophagitis: an updated systematic review and meta-analysis AJ Lucendo, L Gutiérrez-Ramírez, A Tejera-Muñoz, J Molina-Infante, ... Clinical Gastroenterology and Hepatology , 2025 2025 Citations: 22
Encuesta para conocer la percepción sobre la educación sexual en adolescentes IM Velasco-Gijón, A Polo-Oliver, L Gutiérrez-Ramírez, Á Arias-Arias, ... Revista Española de Salud Pública 98, e202402005 , 2025 2025 Citations: 14
Impact of an educational intervention about healthy lifestyles in teenagers JC Medrano-Sánchez, C Vela-Meco, L Gutiérrez-Ramírez, Á Arias-Arias, ... Medicina de Familia. SEMERGEN 50 (5), 102191 , 2024 2024 Citations: 7
The Association Between Helicobacter pylori Infection and Eosinophilic Esophagitis: Systematic Review and Meta‐Analysis L Gutiérrez‐Ramírez, SL Garcia‐Dionisio, S Feo‐Ortega, ... Helicobacter 30 (2), e70038 , 2025 2025 Citations: 6
Reduced port laparoscopic sleeve gastrectomy: a systematic review and meta-analysis L Gutierrez-Ramirez, A Morandeira-Rivas, E Medina-Benitez, ... Obesity Surgery 34 (12), 4519-4530 , 2024 2024 Citations: 5
Producción científica del Hospital General La Mancha Centro.: Análisis bibliométrico histórico LG Ramírez, ÁA Arias, AT Muñoz Actas científicas mancha centro (ACMC) 2 (2), 6-17 , 2024 2024 Citations: 2
Encuesta para conocer la percepción sobre la educación sexual en adolescentes: e202402005 IM Velasco-Gijón, A Polo-Oliver, L Gutiérrez-Ramírez, Á Arias-Arias, ... Revista Española de Salud Pública 98, 16 páginas-16 páginas , 2024 2024 Citations: 1
Impacto del ayuno intermitente en pacientes con diabetes mellitus tipo 1 J de la Calle Rodríguez, MCG Cano, C Fernández, S García, ÁA Arias, ... Actas científicas mancha centro (ACMC) 4 (1), 5-32 , 2026 2026
P-476-CALIDAD DE VIDA TRAS COLECISTECTOMÍA LAPAROSCÓPICA. IMPACTO DE LA HERNIA DE ORIFICIO DEL TRÓCAR GR Lucía, SP Nuria, LS María, MR Antonio, VCV CRISTINA, C VANESA, ... Cirugía Española 102, 958-959 , 2024 2024
P-261-IMPACTO DE LAS TÉCNICAS DE RECONSTRUCCIÓN TRAS DUODENOPANCREATECTOMÍA EN EL RETRASO DEL VACIAMIENTO GÁSTRICO. REVISIÓN SISTEMÁTICA Y METANÁLISIS DE RED CV Cristina, GR Lucía, MR Antonio, AA Ángel, F ELENA, SP Nuria, ... Cirugía Española 102, 480-481 , 2024 2024
Survey to know the perception of sexual education in adolescents IM Velasco-Gijón, A Polo-Oliver, L Gutiérrez-Ramírez, Á Arias-Arias, ... Revista Española de Salud Pública 98, e202402005 , 2024 2024
P-080-RESULTADOS COMUNICADOS POR EL PACIENTE TRAS CIRUGÍA BARIÁTRICA TENDENCIA EN LA UTILIZACIÓN DE INSTRUMENTOS DE MEDICIÓN. REVISIÓN SISTEMÁTICA GR DE LA SERNA, MR ANTONIO, GR LUCÍA, CT JAVIER, ... Cirugía Española 102, 60-61 , 2024 2024
Impact of an educational intervention about healthy lifestyles in teenagers:(Pag.-e 102191) JCM Sánchez, CV Meco, LG Ramírez, ÁA Arias, AT Muñoz Semergen: revista española de medicina de familia, 6-6 , 2024 2024
O-218-UTILIDAD DE LA REALIDAD VIRTUAL INMERSIVA EN LA REDUCCIÓN DE LA ANSIEDAD PREOPERATORIA. REVISIÓN SISTEMÁTICA F ELENA, MR ANTONIO, GR LUCÍA, SP NURIA, MR ESTHER, ... Cirugía Española 102, 620-621 , 2024 2024
Encuesta para conocer la percepción sobre la educación sexual en adolescentes IMV Gijón, AP Oliver, LG Ramírez, ÁA Arias, AT Muñoz Revista española de salud pública, 41 , 2024 2024
Efficacy of Dietary Therapy for Eosinophilic Esophagitis in Children and Adults: An Updated Systematic Review and Meta-Analysis Á Arias Arias, A Tejera-Muñoz, L Gutiérrez-Ramírez, J Molina-Infante, ... MDPI , 2024 2024
Red Equator: una herramienta para mejorar la comunicación científica AT Muñoz, LG Ramírez, ÁA Arias Actas científicas mancha centro (ACMC) 1 (1), 18-35 , 2023 2023