LALCHAND DAYANAND DEVHARE

D. Devhare graduated from Sharad Powar college of Pharmacy Nagpur in 2013 with a B. Pharm in Pharmaceutical Sciences and Post graduated from same college in 2015 with a M. Pharm in Quality Assurance and Doctorate from Oriental University Indore in 2023 with Ph. D.
The author also has a qualification such as DNYS, PGDBM, PGDFSQM and BEMS. At present the author is working as Principal at Manwatkar College of Pharmacy, Ghodpeth, Chandrapur, Maharashtra, India. He has more than 30 publication in various reputed national and international journals, attained more than 25 conferences worldwide, Grant 11 patent in different country, Life member in different association and Award received “Bharat Gaurav Puraskar”, “ Ambedkar Manavi Hakk Puraskar” “India Proud Book of Records” & “Best Paper Award”. As well as he is an author of another 11 books.

EDUCATION

Graduated from Sharad Powar College of Pharmacy Nagpur in 2013 with a B. Pharm in Pharmaceutical Sciences and Post graduated from the same college in 2015 with an M. Pharm in Quality Assurance and Doctorate from Oriental University Indore in 2023 with Ph. D.
The author also qualifies such as DNYS, PGDBM, PGDFSQM, and BEMS.

RESEARCH, TEACHING, or OTHER INTERESTS

Medicine, Multidisciplinary, Health Informatics, General Medicine

Scopus Publications

Development and In-Vitro Categorization of Cilnidipine-loaded Transdermal Patches: Design, Evaluation, and Performance Assessment
Lalchand D Devhare, Sachin Hiradeve, Vaibhav Uplanchiwar, Vinod Thakare, Namrata S Mane, Pravinkumar B Suruse, Kurtika Channe
Journal of Pharmaceutical Innovation, 2026
Enhancing Risperidone Delivery through Optimized Niosomal Formulation Using Central Composite Design
International Journal of Drug Delivery Technology, 2026
Formulation, Optimization and In-Vitro Assessment of a Montelukast Sodium-Loaded Proniosomal Gel for Sustained Drug Delivery in Asthma Management
Lalchand Devhare, Anitha K N, Kazi Sarfaraz Masoodali, Anita .A, Shobha A. Ubgade, Krishnakant B Bhelkar, Tufail Dana
International Journal of Drug Delivery Technology, 2025
Montelukast Sodium is widely used for the management of asthma,but its low bioavailability due to the first-pass effect limits its therapeutic efficacy. A novel proniosomal gel-based delivery system can enhance EE, improve stability, and provide sustained drug discharge over an extended period.This study aims to formulate and assess a Montelukast Sodium proniosomal gel using different non-ionic surfactants, penetration enhancers, and gelling agents to optimize drug encapsulation, stability, and controlled drug discharge.Montelukast Sodium proniosomal gel was made using the coacervation phase separation approach. Varioussurfactants (Span 20/60/80, Tween 20/80), cholesterol (to control drug leakage), soya lecithin (as a penetration enhancer), and carbopol (as a gelling agent) were incorporated. The formulations were assessed for Fourier-transform infrared compatibility studies, vesicle size analysis, scanning electron microscopy (SEM), drug entrapment efficiency (EE), drug content, rheological behavior, in vitro drug discharge, and stability as per ICH Q1C guidelines.The study confirmed that Montelukast Sodium was successfully entrapped in all nine formulations. The type of surfactant and cholesterol content significantly influenced drug discharge and EE. FTIR analysis indicated no drug-excipient interactions, and SEM studies revealed uniform, spherical vesicles. The vesicle size of the optimized formulation (F2) ranged from 3.33±0.12 to 5.83±0.21 µm, with an EE of 54.46±0.50% and a drug discharge of 90.81±0.031%. The discharge kinetics followed a zero-order model and fitted the Higuchi equation, suggesting Super-Case II transport diffusion. Stability studies demonstrated that the formulation remained stable for 90 days, with the highest drug retention observed at 4°C.The optimized proniosomal gel formulation (F2) exhibited enhanced drug entrapment, prolonged drug discharge, and improved stability, making it a promising alternative for sustained delivery of Montelukast Sodium in asthma management.
Combatting antibiotic resistance: Leveraging fecal microbial transplantation for gut health
Prashasti Upreti, Lalchand D. Devhare, Lara Hashim Abdulmageed, Yamjala Ganesh Kumar, Rajesh Kumar, G. Dharmamoorthy
Emerging Paradigms for Antibiotic Resistant Infections Beyond the Pill, 2024
Diverse properties of Tinospora cordifolia (giloy, heart leaved moonseed) world wild use for immunotherapies; boosting the body's defense and immune support
Preeti Semwal, Biresh Kumar Sarkar, Kumari Sonu, Garima Chand, Lalchand D. Devhare, Tanuj Hooda
Emerging Paradigms for Antibiotic Resistant Infections Beyond the Pill, 2024
Quality by Design Approach to Nasal Mucoadhesive Microspheres: Enhanced Sumatriptan Succinate Delivery through Formulation and Characterization
Shivanee . Vyas, Anitha K N, Niranjan Babu Mudduluru, Lalchand D Devhare
International Journal of Drug Delivery Technology, 2024
The primary therapeutic indications for sumatriptan succinate (STS) include the treatment of migraine and cluster headaches. To enhance mucoadhesion, sodium carboxymethyl cellulose (SCMC) and hydroxyl propyl methyl cellulose (HPMC K15M) were used in this study to develop nasal mucoadhesive microspheres of STS. A central composite design, facilitated by Design Expert software, was employed to assess the impact of polymer concentrations on mucoadhesion, involving nine different formulations. The study’s findings indicated that the microspheres were uniformly sized and spherical and that the polymers were compatible with STS. The optimal formulation, consisting of 220.711 mg of SCMC and 150 mg of HPMC K15M, demonstrated the highest level of mucoadhesion. This combination effectively regulated the discharge of STS from the mucoadhesive microspheres and significantly improved their mucoadhesive properties. These results suggest that the strategic use of SCMC and HPMC K15M can enhance the performance of nasal mucoadhesive microspheres, ensuring a controlled release of STS and improved adhesion to mucosal surfaces. This has the potential to optimize the therapeutic efficacy of STS in treating migraine and cluster headaches.
Therapeutic and Phytochemical Properties of Thymoquinone Derived from Nigella sativa
Gaurav Tiwari, Monisha Gupta, Lalchand D. Devhare, Ruchi Tiwari
Current Drug Research Reviews, 2024
Background: Nigella sativa (N. sativa), commonly known as black seed or black cumin, belongs to the family Ranunculaceae. It contains several phytoconstituents, Thymoquinone (TQ), thymol, thymohydroquinone, carvacrol, and dithymoquinone. TQ is the main phytoconstituent present in N. sativa that is used as an herbal compound, and it is widely used as an antihypertensive, liver tonic, diuretic, digestive, anti-diarrheal, appetite stimulant, analgesic, and antibacterial agent, and in skin disorders. Objective: The study focused on collecting data on the therapeutic or pharmacological activities of TQ present in N. sativa seed. Methods: Antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, hepato-protective, renal protective, and antioxidant properties of TQ have been studied by various scientists. Conclusion: TQ seems to have a variety of consequences on how infected cells behave at the cellular level.
Optimizing Verapamil Hydrochloride In-situ Delivery: A Strategic Formulation Approach using Box-Behnken Design for Enhanced Performance and Comprehensive Evaluation of Formulation Parameters
Ram K Choudhary, Sulochana Beeraka, Biresh K Sarkar, G Dharmamoorthy, Lalchand Devhare
International Journal of Drug Delivery Technology, 2024
This study focuses on formulating and assessing an in-situ gastro-retentive gel for precise delivery of verapamil hydrochloride to the stomach, aiming to extend its residence time and improve targeted delivery. Gels were synthesized in-situ using a cation-controlled gelation method, incorporating varied blends of pectin and HPMCK4M. Design Expert’s box behnken design was employed to assess responses such as buoyancy lag time, water uptake, and cumulative drug discharge. Results revealed that the developed gels exhibited a total float time exceeding 10 hours, with formulation T-2 showing the least floating lag time and a cumulative drug release of 99.40 ± 3.24% over 10 hours. This suggests effective prolongation of the gastric residence time, enabling controlled verapamil hydrochloride release. Additional evaluations, including appearance, pH, viscosity, in-vitro gel formation, drug content, density, and gel force, supported the robustness of the developed gels. Subsequent in-vitro dissolution and stability studies affirmed consistent active ingredient content, highlighting formulation stability over time. In conclusion, this study demonstrates that the in-situ gels effectively extend gastric residence time, facilitating controlled verapamil hydrochloride release, marking significant advancements in drug delivery systems and targeted drug delivery within the gastrointestinal tract.
Synthesis, DNA Binding, Molecular Docking and Anticancer Studies of Copper (II), Nickel (II), and Zinc (II) Complexes of Primaquine-based Ligand
M Gnana Ruba Priya, Lal Prasanth ML, Lalchand D Devhare, Shaik K Yazdan, Sachinkumar Gunjal
International Journal of Pharmaceutical Quality Assurance, 2024
In a research study, a metal-based complex demonstrated anticancer properties. The process involved the synthesis of a compound called 7-chloro-N-[5-(diethylamino)pentan-2-yl]-N-[sulfanyl(carbonothioyl)]quinolyn-4-amine, which incorporated a primaquine-based dithiocarbamate ligand. This synthesis method utilized sodium hydroxide and carbon disulfide at temperatures of 0 to 5℃. Nickel(II), copper(II), and zinc(II) ions were employed as the metal-complexed ligands through various chromatographic and spectroscopic techniques that enhanced their purity. Metal compounds, such as cisplatin and its analogs, were widely used to treat different cancer types. Presently, researchers are exploring alternative metal-based complexes as potential agents against cancer, aiming to mitigate toxic effects linked to medications made of platinum. Investigations conducted in-silico revealed that the ligand preferred interacting with DNA’s minor groove, assembling a single hydrogen bond between an adenine hydrogen atom and the oxygen element of the carbonyl compound in the pyrrolidinone unit. Compared to cisplatin, copper complexes can overcome drug resistance by lowering their toxicity. The findings indicate that these primaquine analogs have the potential to lay the foundation for a novel and efficacious category of cancer chemotherapeutics.
Design Development and Characterization of Nicardipine Solid Lipid Nano-Particulars
Kotha Kranthi Kumar, Vema Kiran, Ram Kumar Choudhary, Lalchand D Devhare, Sachinkumar Dnyaneshwar Gunjal
International Journal of Drug Delivery Technology, 2024
The present work was designed and characterized nicardipine solid lipid nano-particulars and formulated into capsule. The formulation was evaluated and stability also as per the specified limits. The nanoparticles were prepared by solid hydrophilic adsorbents. The obtained ratio of 1:1:1:2 of drugs, soy PC, DMPC, and labrasol shows the highest dissolved in water. The liquid form was converted into a solid product using an adsorbent like anhydrous lactose and aerosil 200. The above results indicated aerosil 200 containing which helped in enhanced dissolve state in water. The results indicated the formulation trial-6 %drug content -100.2, entrapment efficiency 84.13 ± 1.64, zeta potential measurement 0.789 ± 0.32, Drug release rate at 3rd hour 81.6% and relative bioavailability of optimized nanoparticle formulation (CNF-6) was significantly increased. As a result, the produced lipid-based formulation shown potential as a method for improving the transfer of lipophilic chemicals that are weakly water-soluble to the aqueous phase, hence improving oral bioavailability
Formulation and Evaluation of Mosquito Repellent Stick
Bobde K Shriram, Lalchand D Devhare, Archana Mehrotra, Savita S Deokar, Surya P Singh
International Journal of Drug Delivery Technology, 2023
Synthesis, Characterisation, Molecular Docking Studies and Biological Evaluation of Novel Benzothiazole Derivatives as EGFR Inhibitors for Anti-breast Cancer Agents
Gnana R. Priya M, Lalchand D. Devhare, G. Dharmamoorthy, Mahendra V. Khairnar, R. Prasidha
International Journal of Pharmaceutical Quality Assurance, 2023
Synthesis and In-vivo Anticancer Evaluation of N-(4-oxo-2-(4-((5-aryl-1,3,4 thiadiazole-2yl) amino) Phenyl thiazolidine-3-yl) Benzamide derivative
Amit Chawla, Lalchand Devhare, G. Dharmamoorthy, Ritika ., Sachin Tyagi
International Journal of Pharmaceutical Quality Assurance, 2023
Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases
Anil K. Adimulapu, Lalchand D. Devhare, Anasuya Patil, Nilesh O. Chachda, G. Dharmamoorthy
International Journal of Drug Delivery Technology, 2023
An updated review on recent developments and applications of fish collagen
Pharma Times, 2023
Microemulgel-based Hydrogel of Diclofenac Sodium using Lipidium sativum as a Gelling Agent
Minal Sonule, Lalchand D Devhare, M Niranjan Babu, Sachinkumar D Gunjal, S Varalaxmi
International Journal of Drug Delivery Technology, 2023
Antioxidant and Antiulcer property of different solvent extracts of Cassia tora Linn.
Lalchand D. Devhare, Niharika Gokhale
Research Journal of Pharmacy and Technology, 2022
Pharmacological assessment of antiulcer activity of gloriosa superba linn tubers in experimentally induced gastric ulcers
Vaibhav P Uplanchiwar
Journal of Medical Pharmaceutical and Allied Sciences, 2021

RECENT SCHOLAR PUBLICATIONS

Development and In-Vitro Categorization of Cilnidipine-loaded Transdermal Patches: Design, Evaluation, and Performance Assessment
LD Devhare, S Hiradeve, V Uplanchiwar, V Thakare, NS Mane, ...
Journal of Pharmaceutical Innovation 21 (4), 406 , 2026
2026
Citations: 1
Alpha-Lipoic Acid: Mechanisms and Clinical Evidence in Diabetic Neuropathy
BK Sarkar, KN Anitha, LD Devhare, S Umadevi, GN Lodhi, ...
Antioxidants and Functional Foods for Diabetic Neuropathy: Prevention and … , 2026
2026
Co-enzyme Q10 in Diabetic Neuropathy: Mechanisms of Action and Clinical Evidence
LD Devhare, YG Kumar, S Priya, A Verma, M Dubey, TN Aparna
Antioxidants and Functional Foods for Diabetic Neuropathy: Prevention and … , 2026
2026
Diagnostic Approaches in Diabetic Neuropathy & Differential Diagnosis: Distinguishing Diabetic Neuropathy from Other Conditions
NT Rangari, YG Kumar, LD Devhare, GN Deodhar, NA Muddalwar, ...
Antioxidants and Functional Foods for Diabetic Neuropathy: Prevention and … , 2026
2026
Alpha-Lipoic Acid: Mechanisms
BK Sarkar, KN Anitha, LD Devhare, S Umadevi, GN Lodhi, ...
Antioxidants and Functional Foods for Diabetic Neuropathy: Prevention and … , 2026
2026
Enhancing Risperidone Delivery through Optimized Niosomal Formulation Using Central Composite Design
YG Kumar, PK Devibala, S Shrivastav, JD Babu, J Chauhan, LD Devhare, ...
Int J Drug Deliv Technol 16 (10s), 741-748 , 2026
2026
Citations: 1
Quinazoline Derivatives as Potential Therapeutic Agents in Breast Cancer, Cervical Cancer, and Ovarian Cancer Therapy
AV Badarinath, N Kumari, GN Deodhar, B Geetha, NA Muddalwar, ...
Vascular and Endovascular Review 8 (8s), 65-76 , 2025
2025
Autophagy: A Critical Review of Cellular Homeostasis and Pathophysiology
S Deogade, S Shende, C Prasad, M Dorlikar, P Urade, LD Devhare
Asian Journal of Advanced Research and Reports 19 (2), 280-287 , 2025
2025
Citations: 3
Comparative review of bioactive molecules for antidiabetic properties
S Shende, G Goyanar, C Prasad, P Urade, L Devhare
Asian J Adv Res Rep 19 (1), 340-54 , 2025
2025
Citations: 1
Micro Needles Patch for Insulin: Transforming Drug Delivery in Diabetes Management
YG Kumar, KN Anitha, A Verma, SL Agrawal, N Motiram, HAS Gawai, ...
Journal of Neonatal Surgery 14 (2s) , 2025
2025
Citations: 4
Phytopharmaceutical Interventions in Neurodegenerative Disorders: Emerging Trends and Prospects
C Spandana, KN Anitha, J Muddagoni, NM Gawai, V Chauhan, ...
Journal of Neonatal Surgery 14 (2s) , 2025
2025
Citations: 3
Herbal Approaches To Skin Lightening: A Comprehensive Review
C Prasad, LD Devhare, A Khobragade, S Shende
International Journal of Pharmaceutical Sciences and Research 16 (1), 62-68 , 2025
2025
Citations: 3
Diverse Properties of Tinospora cordifolia (Giloy, Heart Leaved Moonseed) World Wild Use for Immunotherapies; Boosting the Body’s Defense and Immune Support
P Semwal, BK Sarkar, K Sonu, G Chand, LD Devhare, T Hooda
Emerging Paradigms for Antibiotic-Resistant Infections: Beyond the Pill, 471-487 , 2024
2024
Citations: 1
Combatting antibiotic resistance: Leveraging fecal microbial transplantation for gut health
P Upreti, LD Devhare, LH Abdulmageed, YG Kumar, R Kumar, ...
Emerging paradigms for antibiotic-resistant infections: Beyond the pill, 211-232 , 2024
2024
Citations: 31
Emerging Paradigms for Antibiotic-Resistant Infections: Beyond the Pill
M Gangwar, G Nath
Springer Nature , 2024
2024
Citations: 9
Therapeutic and phytochemical properties of thymoquinone derived from Nigella sativa
G Tiwari, M Gupta, LD Devhare, R Tiwari
Current Drug Research Reviews Formerly: Current Drug Abuse Reviews 16 (2 … , 2024
2024
Citations: 62
Next-Generation Drug Delivery Strategies for Personalized Healthcare
S Shende, L Devhare, C Prasad, A Khobragade, A Khapne
Pharmaceutical Research - Recent Advances and Trends 2, 28-62 , 2024
2024
Citations: 9
Case Study On Rubella Virus.
D Devnani, KK Prasad, K Bongade, A Verma, T Choudhary, MK Posa, ...
Journal of Advanced Zoology 45 (2) , 2024
2024
Citations: 9
Research Methodology and Biostatistics
LD Devhare, RK Choudhary, KK Kurella, FD Ghadi, J Mundlia, ...
IIP Publication 1, 165 , 2024
2024
Citations: 9
Diverse Properties of Tinospora Cordifolia (Giloy, Heart Leaved Moonseed) world wild use for immunotherapies; boosting the body’s defence and immune support
G Chand, LD Devhare, T Hooda
Emerging Paradigms for Antibiotic-Resistant Infections: Beyond the Pill … , 2024
2024
Citations: 16

MOST CITED SCHOLAR PUBLICATIONS

Therapeutic and phytochemical properties of thymoquinone derived from Nigella sativa
G Tiwari, M Gupta, LD Devhare, R Tiwari
Current Drug Research Reviews Formerly: Current Drug Abuse Reviews 16 (2 … , 2024
2024
Citations: 62
Antioxidant and Antiulcer property of different solvent extracts of Cassia tora Linn.
LD Devhare, N Gokhale
Research journal of pharmacy and technology 15 (3), 1109-1113 , 2022
2022
Citations: 58
Acid neutralizing capacity and antimicrobial potential of selected solvent extract from various indigenous plants
LD Devhare, N Gokhale
Journal of Advanced Scientific Research 12 (04), 175-179 , 2021
2021
Citations: 43
A recent review on bioavailability and solubility enhancement of poorly soluble drugs by physical and chemical modifications
L Devhare, PK Kore
Research chronicle in health sciences 2 (5), 299-308 , 2016
2016
Citations: 43
Synthesis, characterisation, molecular docking studies and biological evaluation of novel benzothiazole derivatives as EGFR inhibitors for anti-breast cancer agents
RPM Gnana, LD Devhare, G Dharmamoorthy, MV Khairnar, R Prasidha
International Journal of Pharmaceutical Quality Assurance 14 (3), 475-480 , 2023
2023
Citations: 40
An updated review on recent developments and applications of fish collagen
R Tiwari, J Mishra, LD Devhare, G Tiwari
Pharma Times 55 (6), 28-36 , 2023
2023
Citations: 39
In silico anti-ulcerative activity evaluation of some bioactive compound from Cassia tora and Butea monosperma through moleculer docking approach
LD Devhare, N Gokhale
International journal of pharmaceutical sciences and research 14 (2), 1000-08 , 2023
2023
Citations: 38
Development And Validation Of Vierordt's Spectrophotometric Method For Simultaneous Estimation Of Drotaverine And Nimesulide Combination
AAMLD Devhare
Research Chronicle in Health Sciences 3 (2), 22-28 , 2017
2017
Citations: 38
Method development for determination of water content from various materials by spectrophotometry and it’s validation
LD Devhare, AP Ghugare, BP Hatwar, DC Goupale, LD Devhare
International journal of drug delivery 7 (4), 233-240 , 2015
2015
Citations: 38
A brief review on: phytochemical and antiulcer properties of plants (fabaceae family) used by tribal people of gadchiroli maharashtra
LD Devhare, N Gokhale
International journal of pharmaceutical sciences and research 14 (4), 1572-1593 , 2023
2023
Citations: 37
Pharmacological assessment of antiulcer activity of gloriosa superba linn tubers in experimentally induced gastric ulcers
VP Uplanchiwar, SY Raut, LD Devhare
Journal of medical pharmaceutical and allied science 10 (3), 2852-2856 , 2021
2021
Citations: 36
Development and Validation of Analytical Methods for Drotaverine and Nimesulide Combination
AAMLD Devhare
Research Chronicle in Health Sciences 3 (3), 40-44 , 2017
2017
Citations: 35
Quantitative Estimation of Bacoside A in Polyherbal Memory Enhancer Syrup for Memory Boosting Activity Using HPTLC Method.
LDD T. U. Tonde, R. H. Kasliwal
Research Chronicle in Health Sciences 2 (6), 315-320 , 2016
2016
Citations: 35
Formulation and evaluation of mosquito repellent stick
BK Shriram, LD Devhare, A Mehrotra, SS Deokar, SP Singh
International Journal of Drug Delivery Technology 13 (4), 1283-1286 , 2023
2023
Citations: 33
Combatting antibiotic resistance: Leveraging fecal microbial transplantation for gut health
P Upreti, LD Devhare, LH Abdulmageed, YG Kumar, R Kumar, ...
Emerging paradigms for antibiotic-resistant infections: Beyond the pill, 211-232 , 2024
2024
Citations: 31
Formulation and in vitro evaluation of dental gel containing ethanglic extract of Mimosa pudica
SS Bodhankar, LD Devhare, AS Meshram, DW Moharkar, CB Badwaik
European Chemical Bulletin 12 (5), 1293-1299 , 2023
2023
Citations: 31
Microemulgel-based hydrogel of diclofenac sodium using Lipidium sativum as a gelling agent
M Sonule, LD Devhare, MN Babu, SD Gunjal, S Varalaxmi
International Journal of Drug Delivery Technology 13 (4), 1235-1239 , 2023
2023
Citations: 30
An update on morphology, mechanism, lethality, and management of dhatura poisoning
S Singh, KH Minj, LD Devhare, SV Uppalwar, S Anand, A Suman, ...
Eur. Chem. Bull 12 (5), 3418-3426 , 2023
2023
Citations: 29
Exploring the potential of Aerva Lanata extract in a herbal ointment for fungal infection treatment
PB Suruse, BA Jadhav, LG Barde, LD Devhare, S Singh, KH Minj, ...
Journal of Survey in Fisheries Sciences 10 (1), 1922-1932 , 2023
2023
Citations: 29
Important role of food and nutritional security during Covid-19: A survey
LD Devhare, SS Bodhankar, P Warambhe, SV Uppalwar, DL Devhare, ...
cancer 4, 5 , 2023
2023
Citations: 29