K Sreedhara Ranganath Pai
@manipal.edu
Scopus Publications
- Targeting glioblastoma with HDAC inhibitors: insights into hydroxamic acid-based therapeutic strategies
Padmini Pai, Ipshita Das, Yashaswini Reddy, Babu Santhi Venkidesh, Poonam Bhandari, Manjunath Madalageri, Veeresh Sadashivanavar, Karkala Sreedhara Ranganath Pai, Pallavi Rao, Srinivas Oruganti, Manasa Gangadhar Shetty, Kapaettu Satyamoorthy, Babitha Kampa Sundara
Acta Neuropathologica Communications, 2026
Epigenetic modifications play crucial roles in glioblastoma growth and aggressiveness, with key regulators including histone deacetylases (HDACs), histone acetyltransferases (HATs), and methyltransferases. Targeting these epigenetic alterations has emerged as a promising therapeutic strategy, utilizing DNA methyltransferase (DNMT) inhibitors, HDAC inhibitors (HDACis), and miRNA-based therapies. HDACis, whose effect on p53, p21, Bax, and Bcl-2, have gained significant interest because of their ability to restore the expression of tumor suppressor genes, thereby inducing apoptosis and overcoming therapeutic resistance. Our study demonstrated that a novel hydroxamic acid analogue, compound 3B, effectively inhibited glioma cell (C6) proliferation and exhibited potent anticancer activity. Compound 3B induced G2/M phase cell cycle arrest, increased apoptotic cell populations, and significantly reduced colony formating efficiency. Confocal imaging revealed nuclear condensation and elevated reactive oxygen species (ROS) levels, indicating oxidative stress. Western blot analysis confirmed that HDAC inhibition increased AcH3K9 protein levels. Further, studies in in vivo xenograft model and allograft C6 Wistar rat model revealed strong antitumour activity, suggesting that compound 3B is a promising therapeutic candidate for glioblastoma treatment. - In silico and in vitro evaluation of risedronate as a DKK1 antagonist: Implications for neuroprotection through DKK1–LRP6 modulation
Suman Manandhar, Anusha Govindula, Kokou Atchou, Ajmal Nassar, Shama Prasada Kabekkodu, K Sreedhara Ranganath Pai
European Journal of Pharmacology, 2026
Dickkopf-1 (DKK1) mediated dysregulation of the Wnt/β-catenin signaling pathway contributes to synaptic loss in Alzheimer's disease (AD). Risedronate, a third-generation bisphosphonate, shows promise in pathologies related to the Wnt pathway, although its direct interaction with the DKK1-LRP6 complex has yet to be investigated. This study aimed to characterize risedronate as a novel small-molecule DKK1 antagonist and evaluate its capacity to restore canonical Wnt signaling and provide neuroprotection. In silico studies were performed using the Schrödinger Maestro (v2018-3) platform, utilizing molecular docking, molecular simualtion, SiteMap and WaterMap analysis to define the thermodynamic hydration energetics of the DKK1-LRP6 interface. In vitro validation was conducted using LRP6-overexpressing HEK-293T cells, with Wnt modulation quantified via immunofluorescence of membrane-associated DKK1 and β-catenin stabilization assays and neuroprotective assay in presence of glutamate in SHSY5Y cells. In silico analysis identified a high-affinity binding site on the DKK1 C-terminal domain (Dscore: 0.998). WaterMap analysis and simulation study revealed that risedronate binding is driven by the displacement of high-energy "unfavorable" water molecules (ΔG > 0) at the Arg203/Lys222 residue cluster. In HEK-293LRP6 cells, risedronate (IC 50 : 65.94 μM) significantly attenuated DKK1-mediated LRP6 sequestration (p < 0.0001), acting as a molecular "plug" to restore β-catenin signaling. This restoration successfully suggests a potential modulation of downstream of Wnt pathway restoration. Risedronate demonstrates potential inhibitory effects on DKK1 in in vitro and in silico models. By bridging bone pharmacology and neurobiology, this study provides a mechanistically grounded repurposing strategy to counteract Wnt signaling failure in neurodegenerative disorders. - Targeting P2X7 receptor/NLRP1 inflammasome axis and gut dysbiosis: A mechanistic review of pyroptosis in metabolic inflammation
Kokou Atchou, Manjunath Madalageri, Suman Manandhar, K. Sreedhara Ranganath Pai
Experimental and Molecular Pathology, 2026
BACKGROUND: Obesity and type 2 diabetes (T2D) are chronic metabolic disorders characterized by persistent low-grade systemic inflammation. While the NLRP3 inflammasome is well-documented, the NLRP1 inflammasome has recently emerged as a proximal molecular ""tripwre" that initiates pyroptotic cell death and cytokine maturation, driving metabolic decline. MECHANISMS: Hyperglycemia and lipotoxicity induce cellular stress, leading to the release of extracellular ATP (eATP) through Pannexin-1 channels. Simultaneously, dysbiosis-induced "leaky gut" facilitates the systemic translocation of lipopolysaccharides (LPS). These DAMPs and PAMPs activate the P2X7 receptor (P2X7R) and Toll-like receptor (TLR) signaling pathways, respectively, triggering the NLRP1 inflammasome. Once activated via functional degradation, the human NLRP1 C-terminal fragment recruits caspase-1, either directly via its CARD domain or through the ASC adaptor, to cleave gasdermin D (GSDMD) and pro-inflammatory cytokines (IL-1β and IL-18). This process executes inflammatory pyroptosis in adipocytes and pancreatic β-cells. Crucially, NLRP1 also serves as an intrinsic negative regulator of the Th17/STAT3 axis; its dysregulation leads to uncontrolled IL-17 production and the activation of JNK/NF-κB pathways. This signaling cascade inhibits the IRS-1/PI3K/AKT axis and impairs insulin secretion by downregulating GLUT2, PDX-1, and GCK. CONSEQUENCES AND TREATMENTS: Chronic NLRP1 hyperactivation fosters a self-perpetuating "vicious cycle" of tissue damage, insulin resistance, and β-cell attrition, leading to macrovascular and microvascular complications. To disrupt this cascade, a multi-faceted therapeutic approach is required. Restoring the intestinal barrier through probiotics and short-chain fatty acids (SCFAs) can limit the circulation of inflammatory primers. Concurrently, targeting the P2X7R/NLRP1 axis with specific antagonists and inflammasome inhibitors provides a pragmatic strategy to reduce systemic inflammation. This review elucidates the complex interplay between these pathways and proposes a combination therapy to mitigate the chronic inflammatory burden of obesity and T2D. - Computational identification of marine-derived inhibitors of Cyclophilin D and Protease-Activated Receptor-1 for the treatment of ischemic disease
Veeresh Sadashivanavar, Manjunath Madalageri, Raghavendra Kinnal, Krishnadas Nandakumar, Ruchi Verma, K Sreedhara Ranganath Pai
Journal of Molecular Graphics and Modelling, 2026
Myocardial infarction (MI) and stroke are examples of ischaemic diseases that continue to pose serious health risks since few specific treatments address the underlying molecular causes of these conditions, which include pathological thrombosis and mitochondrial dysfunction. In order to close this gap, we used an integrated in-silico method to find strong inhibitors for Protease-Activated Receptor-1 (PAR-1) and Cyclophilin D (CypD) from the structurally diverse CMNPD marine natural product library. To account for protein flexibility, our method combines High Throughput Virtual Screening (HTVS), Standard Precision (SP), and Extra Precision (XP) docking with meticulous Induced Fit Docking (IFD). After undergoing 500 ns Molecular Dynamics (MD) simulations, the best candidate compounds showed remarkable structural stability with RMSD values between 0.6 and 1.7 Å. Strong binding affinities were found by thermal MM-GBSA calculations, with CMNPD29955 showing a ΔG of –63.146 kcal/mol towards CypD and CMNPD3572 and CMNPD22037 showing ΔG values of –96.24 and –98.092 kcal/mol against PAR-1, respectively. Lead molecules of each target were found to have important hydrophobic and hydrogen bonding interactions with crucial active site residues in MD modelling. The dynamic stability and energetic favorability of these chemicals were further confirmed by complementary techniques, including WaterMap, Principal Component Analysis (PCA), and Free Energy Landscape (FEL). In addition to CMNPD3572 and CMNPD22037 as potential PAR-1 antagonists, this work emphasises CMNPD29955 as a new lead inhibitor that targets mitochondrial dysfunction via CypD. To transform computational insights into effective and complementary therapeutic alternatives, lead optimisation, experimental validation, and preclinical assessment of these special marine-derived molecules will be crucial in the future. • By focusing on thrombosis (Protease-Activated Receptor-1 (PAR-1)) and mitochondrial dysfunction (Cyclophilin D (CypD)), an integrated multi-stage in-silico workflow was used to find new treatments for ischemic diseases. • Lead compounds demonstrated excellent dynamic stability during 500 ns molecular dynamics simulations, with RMSD values consistently between 0.6 and 1.7 Å. • MM-GBSA binding free energy calculations revealed strong affinities, including CMNPD3572 and CMNPD22037 for PAR-1 (ΔG ≈ -96 to -98 kcal/mol) and CMNPD29955 for CypD (ΔG ≈ −63 kcal/mol). • Further advanced analyses, such as WaterMap, PCA and Free Energy Landscape studies, confirmed favorable hydration thermodynamics along with stable conformational dynamics and energetically preferred binding states. • CMNPD29955 emerged as a novel marine-derived CypD inhibitor. CMNPD3572 and CMNPD22037 are as PAR-1 inhibitors highlighting a promising strategy to mitigate mitochondrial dysfunction alongside PAR-1–mediated thrombosis in ischemic disorders. - Mannose-functionalized liposomal delivery of levamisole and lipopolysaccharide enhances therapeutic responses through tumor-associated macrophage modulation in colon cancer
Sri Pragnya Cheruku, R.J.A. Vibhavari, Vanishree Rao, Divya Gopalan, Abhisheik Eedara, Yogesh Chandra, Karkala Sreedhara Ranganath Pai, Raghu Chandrashekar Hariharapura, Mallikarjuna Rao Chamallamudi, Sai Balaji Andugulapati, Nitesh Kumar
International Journal of Biological Macromolecules, 2026 - Novel pyridine and 1,3,4-oxadiazole-linked 1,3-thiazole hybrids: Synthesis, anticancer evaluation, and computational insights
Manjunath R, Padmapriya M, Samyak Pandey, Raksha Nayak, K Sreedhara Ranganath Pai, Santosh L Gaonkar
Journal of Molecular Structure, 2026
• 1,3-Thiazole hybrids serve as key scaffolds in drug discovery due to their diverse biological properties. • Efficient synthesis of pyridine and 1,3,4-oxadiazole-conjugated 1,3-thiazole hybrids. • In vitro anticancer activity against the MCF-7 breast cancer cell line using the Sulforhodamine B (SRB) assay. • Molecular docking studies (PDB ID: 3ERT ) to predict favourable binding interactions and orientations within the active site of the target protein. • Molecular dynamics and MM-GBSA analyses to confirm the stability and binding affinity of compounds 7a–h , • DFT studies to find out the energy gaps, reactivity, and stability of compounds 7a-h . • Evaluation of drug-likeness to assess the pharmacokinetic potential of the synthesized hybrids, in agreement with Lipinski’s and Jorgensen’s rules. • Detailed SAR study highlighting the influence of functional groups on the cytotoxic potential of the 1,3-thiazole hybrids. Heterocyclic scaffolds are central to drug discovery due to their diverse pharmacological properties. In this work, novel pyridine and 1,3,4-oxadiazole linked 1,3-thiazole hybrids were designed and synthesized as potential anticancer agents. Their structures were confirmed by various spectroscopic methods, and the compounds were evaluated for cytotoxicity against the MCF-7 breast cancer cell line. Among the series, compound 7a (IC₅₀ = 28.51 ± 1.70 µM) displayed the most potent activity, approaching that of cisplatin (23.44 ± 2.23 µM). Substituent effects revealed that a para-methyl group enhanced activity, whereas electron-withdrawing groups reduced potency. Computational studies (docking, MD simulations, MMGBSA, DFT, and drug-likeness predictions) further supported the experimental findings and highlighted favorable binding interactions. Overall, these results identify 1,3-thiazole hybrids as promising leads for further development in anticancer research. - Quinazoline-oxadiazole hybrids: Synthesis, SC-XRD, Hirshfeld surface analysis and computational investigations
Yogeesha N Nayak, Deepika Dwarakanath, Keshav Kumar Harish, Sreedhara Ranganath Pai, Mahendra Madegowda, Santosh L. Gaonkar
Journal of Molecular Structure, 2026
A novel series of twelve quinazoline-based oxadiazole hybrids was synthesized via a concise four-step synthetic route and comprehensively characterized by FTIR, 1 H NMR, 13 C NMR, and high-resolution mass spectrometry. Single crystal-XRD results confirmed that the para-fluoro-substituted derivative adopts a monoclinic crystal system and is assigned to the P2₁/c space group. The molecular structure featured a nearly coplanar arrangement of the oxadiazole and quinazoline rings, with a dihedral angle of 1.5°, while the fluorophenyl–oxadiazole linkage displayed a dihedral angle of 12.8°, suggesting slight torsional deviation. Hirshfeld surface analysis indicated that intermolecular contacts such as H···F (26.3%), H···N (8.7%), H···O (7.3%), and π···π stacking interactions play a key role in molecular packing and lattice stability. Molecular docking studies were conducted to evaluate the interaction of the synthesized hybrids with histone deacetylase 7 (HDAC7), an epigenetic target implicated in oncogenesis. The docking analysis revealed favorable binding within the HDAC7 active site. Furthermore, a 100 ns molecular dynamics simulation revealed that the HDAC7–ligand complex maintained structural integrity, exhibited minimal RMSD deviations, and preserved key interactions throughout the simulation. ADME predictions using the QikProp module suggested favorable pharmacokinetic properties and drug-likeness. Collectively, the results offer comprehensive structural and computational insights into quinazoline–oxadiazole hybrids, providing a foundation for future biological evaluation. - Quantum Dot Localized Surface Plasmon Resonance Biomedical Applications
E. Vignesh Balaji, K. Sreedhara Ranganath Pai
Lecture Notes in Nanoscale Science and Technology, 2026 - Integrative gene target mapping, RNA sequencing, in silico molecular docking, ADMET profiling and molecular dynamics simulation study of marine derived molecules for type 1 diabetes mellitus
Basavaraj Vastrad, Shivaling Pattanashetti, Veeresh Sadashivanavar, K. S. R. Pai, Chanabasayya Vastrad
Molecular Diversity, 2026 - Neuroprotective potential of Mucuna pruriens in cerebral ischemia: Evidence from animal models and implications for translational neuropharmacology
Vanishri Sunil Nayak, Karkala Sreedhara Ranganath Pai, Bukkambudhi Virupakshamurthy Murlimanju, Sunil Sanjiva Nayak, Suhani Sumalatha, Mamatha Tonse
Veterinary World, 2026
Cerebral ischemia is a major neurological condition that contributes significantly to global morbidity and mortality. It occurs due to reduced blood supply to the brain, leading to neuronal injury and death. The pathophysiology of cerebral ischemia is complex and involves oxidative stress, neuroinflammation, excitotoxicity, mitochondrial dysfunction, and apoptosis. Despite advances in medical management, effective neuroprotective therapies remain limited, creating a need to explore alternative approaches. Mucuna pruriens is a medicinal plant widely used in traditional medicine, known for its rich content of bioactive compounds, including levodopa, flavonoids, alkaloids, and phenolic antioxidants. These compounds are associated with antioxidant, anti-inflammatory, and neuroprotective properties. This review summarizes the available evidence from animal model studies on the role of M. pruriens in the management of cerebral ischemia. The literature indicates that M. pruriens can reduce oxidative stress by enhancing antioxidant enzyme activities, including superoxide dismutase, catalase, and glutathione peroxidase, and by decreasing lipid peroxidation. Histopathological findings suggest that it helps preserve neuronal structure, particularly in vulnerable brain regions such as the hippocampus. Behavioral studies also demonstrate improvements in motor function, coordination, and cognitive performance following treatment with M. pruriens. These effects are mainly attributed to its ability to scavenge free radicals, modulate neurotransmitter levels, and regulate inflammatory pathways. Although the findings from animal studies are promising, variations in experimental design, dosage, and extraction methods limit the consistency of results. In addition, the lack of standardized formulations and clinical evidence restricts its direct application in human patients. In conclusion, M. pruriens shows potential as a natural neuroprotective agent in cerebral ischemia. However, further well-designed experimental and clinical studies are required to establish its safety, efficacy, and standardized therapeutic use. Keywords: Cerebral ischemia, Ischemic stroke, Mucuna, Neuroprotective agents. - Structural insights of AKT and its activation mechanism for drug development
B. Harish Kumar, Shama Prasada Kabekkodu, K. Sreedhara Ranganath Pai
Molecular Diversity, 2025 - Antimicrobial Potential of Aqueous and Ethanolic Extracts of Fruits of Embelia ribes, Rhizomes of Nardostachys jatamansi, and Stolons of Picrorhiza kurroa: An In vitro Investigation
K.L. Shobha, Prathibha Maria D Almeida, K. Sreedhara R. Pai
Journal of Pure and Applied Microbiology, 2025 - Correction to: Comparative study on drug encapsulation and release kinetics in extracellular vesicles loaded with snake venom L - amino acid oxidase (BMC Pharmacology and Toxicology, (2025), 26, 1, (98), 10.1186/s40360-025-00938-8)
Divya Ramesh, Shankar M. Bakkannavar, Vinutha R. Bhat, K. Sreedhara Ranganath Pai, Krishna Sharan
BMC Pharmacology and Toxicology, 2025 - Comparative study on drug encapsulation and release kinetics in extracellular vesicles loaded with snake venom L - amino acid oxidase
Divya Ramesh, Shankar M. Bakkannavar, Vinutha R. Bhat, K. Sreedhara Ranganath Pai, Krishna Sharan
BMC Pharmacology and Toxicology, 2025 - Signaling networks and MiRNA crosstalk in ovarian cancer chemoresistance
Raksha Nayak, Samyak Pandey, Dileep Kumar, Sachindra Kumar, K Sreedhara Ranganath Pai
Journal of Ovarian Research, 2025 - Synthesis, characterization and in silico studies of novel multifunctional imidazole-thiazole hybrids with potent antimicrobial and anticancer properties
Deepika Dwarakanath, Yogeesha N. Nayak, Ananda Kulal, Samyak Pandey, K. Sreedhara Ranganath Pai, Santosh L. Gaonkar
Scientific Reports, 2025 - Mitigating cardiotoxicity of Naja naja venom: Evaluation of a multipronged strategy using anti-snake venom and methanolic extract of Andrographis paniculata
Sujatha Prabhu P., Maya Roche, Ashwini Aithal P., Sreedhara Pai K. Ranganath, Varun Kumar Singh, Akshatha Ganesh Nayak
Journal of Applied Pharmaceutical Science, 2025 - Computational screening and molecular dynamics of natural compounds targeting the SH2 domain of STAT3: a multitarget approach using network pharmacology
Sachindra Kumar, B. Harish Kumar, Raksha Nayak, Samyak Pandey, Nitesh Kumar, K. Sreedhara Ranganath Pai
Molecular Diversity, 2025 - Neprilysin regulates the progression of glioblastoma: an in-vitro study using siRNA mediated gene silencing and HDAC1 mediated upregulation of neprilysin in U87 MG cells
Adarsh Gopinathan, Runali Sankhe, Raghavendra Upadhya, K. Sreedhara Ranganath Pai, Anoop Kishore
Molecular and Cellular Biochemistry, 2025 - In silico drug repurposing in non-small cell lung cancer by docking and molecular dynamic simulations for epidermal growth factor receptor allosteric site inhibition
Swastika Maity, Megh Pravin Vithalkar, Krishnaprasad Baby, Usha Yogendra Nayak, Karkala Sreedhara Ranganath Pai, Yogendra Nayak
Journal of Applied Pharmaceutical Science, 2025 - Corrigendum to “Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors” [Biochem. Biophys. Res. Commun. 729 (2024) 150348] (Biochemical and Biophysical Research Communications (2024) 729, (S0006291X24008842), (10.1016/j.bbrc.2024.150348))
Charudatt Samant, Ramesh Kale, K. Sreedhara Ranganath Pai, Krishnadas Nandakumar, Mandar Bhonde
Biochemical and Biophysical Research Communications, 2025 - The future of diabetes mellitus management: Therapeutic insights from gene and stem cell research
Snigdha Suman Das, E. Vignesh Balaji, K. Sreedhara Ranganath Pai
Gene Reports, 2025 - Voglibose Attenuates Amyloid Beta–Induced Memory Deficits in a Rodent Model: A Potential Alzheimer’s Therapy via Wnt Signaling Modulation
Suman Manandhar, Prasada Chowdari Gurram, Anusha Govindula, Shama Prasada Kabekkodu, K Sreedhara Ranganath Pai
Molecular Neurobiology, 2025 - Corrigendum to “PAK4 inhibition significantly potentiates gemcitabine activity in PDAC cells via inhibition of Wnt/β-catenin, p-ERK/MAPK and p-AKT/PI3K pathways” [Biochemistry and Biophysics Reports, (35), September 2023, 1–8 / 101544] (Biochemistry and Biophysics Reports (2023) 35, (S2405580823001255), (10.1016/j.bbrep.2023.101544))
Charudatt Samant, Ramesh Kale, Anand Bokare, Mahip Verma, K. Sreedhara Ranganath Pai, Mandar Bhonde
Biochemistry and Biophysics Reports, 2025 - Nanocubospray of Epigallocatechin Gallate for Prevention of Oral Submucous Fibrosis
Chetan Hasmukh Mehta, Varalakshmi Velagacherla, Suman Manandhar, Yogendra Nayak, Karkala Sreedhara Ranganath Pai, Shruthi Acharya, Usha Yogendra Nayak
AAPS Pharmscitech, 2025 - Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn
Vasavi Kumblekar, Reshma Kumarchandra, K Sreedhara Ranganath Pai, ShamaPrasada K, Suman Manandhar, Rajeshwari Shastry, Sharada Rai
F1000research, 2025 - Unraveling Structural and Anticancer Properties of Pyridine-Oxadiazole Derivatives: Single-Crystal XRD, Hirshfeld Analysis, and Cytotoxicity against A549 Cells
Yogeesha N. Nayak, Deepika Dwarakanath, Keerthana Suresh Kizhakkanoodan, Rajeev K. Sinha, K. Sreedhara Ranganath Pai, Bharath Raja Guru, Santosh L. Gaonkar
ACS Omega, 2025 - Drugging the Undruggable and beyond: Emerging precision oncology approaches to target acquired resistance to KRAS G12C and KRAS G12D inhibitors
Ramesh Kale, Charudatt Samant, Krishnadas Nandakumar, K. Sreedhara Ranganath Pai, Mandar Bhonde
Biochemical and Biophysical Research Communications, 2025 - AN OVERVIEW OF COPD: ITS ADVANCED THERAPEUTIC MANAGEMENT AND CHALLENGES FOR DRUG RELEASE AT THE TARGETED SITE
SUPRAJA A., GUNDAWAR RAVI, TANVI PAINGINKAR, GIRISH PAI K., VIRENDRA S. LIGADE, K. SREEDHARA RANGANATH PAI, VASANTHARAJU SG, MUDDUKRISHNA BS
International Journal of Applied Pharmaceutics, 2025 - Design, synthesis, In Silico analysis, anti-inflammatory, and cytotoxicity evaluation of Novel Formyl-Pyrazoline derivatives
Yogeesha N Nayak, Samyak Pandey, Sreedhara Ranganath Pai, Neha S Gandhi, Raksha Nayak, Zhang Xi, Vijay Pandey, Basappa Basappa, Santosh L. Gaonkar
Journal of Molecular Structure, 2025 - Mesenchymal Stem Cell-Derived Exosomes in Cancer Resistance Against Therapeutics
Vignesh Balaji Easwaran, K Maya S Pai, K. Sreedhara Ranganath Pai
Cancers, 2025 - In Vitro Cytotoxic Activity and In Vivo Antiproliferative Activity of Ethyl Acetate Fraction of Bunium bulbocastanum Seed Against Prostatic Neoplasia
Mehta Vedant Kamal, Sreedhara Ranganath K. Pai, Gangadhar Hari, Keerthi Priya, Vishwapriya Mahadev Godkhindi, Ananth Pai, Punit Singh Dikhit, Vijetha Shenoy Belle
Proceedings of the National Academy of Sciences India Section B Biological Sciences, 2025 - Molecular docking studies and molecular dynamic simulation analysis: To identify novel ATP-competitive inhibition of Glycogen synthase kinase-3β for Alzheimer’s disease
Suggala Ramya Shri, Yogendra Nayak, Sreedhara Ranganath Pai
F1000research, 2025 - Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination
RUNALI SANKHE, TANVI VIJAY GUJARAN, VIGNESH BALAJI EASWARAN, K. SREEDHARA RANGANATH PAI, PUGAZHANDHI BAKTHAVATCHALAM, HERMAN SUNIL DSOUZA
Oncology Research, 2025 - Design of PI3K-mTOR Dual Inhibitors for Ovarian Cancer: Are we on the Right Track?
Mangala Shenoy K., Ekta Rathi, Karthik S. Udupa, Shama Prasada K., K. Sreedhara Ranganath Pai, Suvarna Ganesh Kini
Current Medicinal Chemistry, 2025 - Exploring acenocoumarol and silodosin in non-small cell lung cancer: Insights into EGFR-linked signaling mechanisms
Swastika Maity, Krishnaprasad Baby, Bharath Harohalli Byregowda, Megh Pravin Vithalkar, Usha Y Nayak, K Sreedhara Ranganath Pai, Yogendra Nayak
F1000research, 2025 - An in silico drug repurposing approach to identify HDAC1 inhibitors against glioblastoma
Adarsh Gopinathan, Runali Sankhe, Ekta Rathi, Triveni Kodi, Raghavendra Upadhya, K. Sreedhara Ranganath Pai, Anoop Kishore
Journal of Biomolecular Structure and Dynamics, 2025 - In silico screening of selected coumarins and Polyphenols to treat Non-small cell lung cancer
Swastika Maity, Jaya Aakriti, Shivaprasad Shetty M, N.V. Anil Kumar, Krishnaprasad Baby, Usha Y Nayak, K Sreedhara Ranganath Pai, Yogendra Nayak
Research Journal of Pharmacy and Technology, 2025 - NETWORK PHARMACOLOGY-BASED COMPUTATIONAL STUDY TO INVESTIGATE THE POTENTIAL MECHANISM OF SYZYGIUM CARYOPHYLLATUM AGAINST COLON CANCER
RAMADEVI PEMMEREDDY, AJAY MILI, BHARATH HAROHALLI BYREGOWDA, JYOTHI GIRIDHAR, SREEDHARA RANGANATH PAI K, ANNA MATHEW, VASUDEV PAI, CHANDRASHEKAR K. S
International Journal of Applied Pharmaceutics, 2025 - Cardiovascular Impacts of Foodborne Toxins
Veeresh Sadashivanavar, Manjunath Madalageri, K. Sreedhara Ranganath Pai, Himanshu Sharma, Praveen Halagali, Raagul Seenivasan, Vamshi Krishna Tippavajhala, Preethi Somanna, Abdullah Al Noman
Physiological Perspectives on Food Safety Exploring the Intersection of Health and Nutrition, 2025 - Ascorbic acid alleviates reproductive toxicity of di-(2-ethyl hexyl) phthalate in female Wistar rats
Kalaivani Manokaran, Ravi Sankar Bhaskaran, Jayesh Mudgal, Prabu Paramasivam, Sachin Shetty, Deepak Nayak, Sunitha Carnelio, Vennila Jaganathan, Dharani Abirama Sundari Shanmugam, Karkala Sreedhara Ranganath Pai
Asian Pacific Journal of Reproduction, 2025 - Pharmacological effects of lesser-known fruiting plants growing in India
Raksha Nayak, Karkala Maya Sreedhara Pai, Vijaya Marakala, Harish Kumar Bastimal, Pankaj Prabhakar, Rhea Katherine D’souza, Sham Prasad Sajankila, Karkala Sreedhara Ranganath Pai, Manjeshwar Shrinath Baliga
Metabolites of Medicinal Plants Insightful Approaches, 2024 - In vitro and in silico insights into antimicrobial and anticancer activities of novel imidazo[2,1-b][1,3,4]thiadiazoles
Deepika Dwarakanath, Yogeesha N. Nayak, Ananda Kulal, Samyak Pandey, K Sreedhara Ranganath Pai, Santosh L. Gaonkar
Scientific Reports, 2024 - Trace elements and metal nanoparticles: mechanistic approaches to mitigating chemotherapy-induced toxicity—a review of literature evidence
Ademola C. Famurewa, Mina Y. George, Cletus A. Ukwubile, Sachindra Kumar, Mehta V. Kamal, Vijetha S. Belle, Eman M. Othman, Sreedhara Ranganath K. Pai
Biometals, 2024 - Oxyresveratrol-β-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies
Tushar Agarwal, Suman Manandhar, Harish Kumar B, Ademola C. Famurewa, Prasada Chowdari Gurram, Ramya Shri Suggala, Runali Sankhe, Jayesh Mudgal, K. Sreedhara Ranganath Pai
Scientific Reports, 2024 - Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors
Charudatt Samant, Ramesh Kale, K. Sreedhara Ranganath Pai, Krishnadas Nandakumar, Mandar Bhonde
Biochemical and Biophysical Research Communications, 2024 - Surface-Conjugated Galactose on Electrospun Polycaprolactone Nanofibers: An Innovative Scaffold for Uterine Tissue Engineering
Srividya Hanuman, Harish Kumar B, K. Sreedhara Ranganath Pai, Manasa Nune
ACS Omega, 2024 - Computational-Based Polyphenol Therapy for Nonsmall Cell Lung Cancer: Naringin Coamorphous Systems for Solubility and Bioavailability Enhancement
Dani Lakshman Yarlagadda, Subham Das, Sai Krishna Anand Vullendula, Suman Manandhar, Swapnil J. Dengale, K. Sreedhara Ranganath Pai, Krishnamurthy Bhat
Molecular Pharmaceutics, 2024 - Inhibition of STAT3: A promising approach to enhancing the efficacy of chemotherapy in medulloblastoma
Sachindra Kumar, Dube Aakash Arwind, Harish Kumar B, Samyak Pandey, Raksha Nayak, Megh Pravin Vithalkar, Nitesh Kumar, K Sreedhara Ranganath Pai
Translational Oncology, 2024 - Phytoconstituents of a Traditional Oil Formulation Inhibits IL-17A and TNF-α involved in Psoriasis: A Molecular Docking Study
Nayak Deeksha Dayanand, Rajasekhar Chinta, Shama Prasada Kabbekodu, Arul Amuthan, Sathish Pai B, K Sreedhara Ranganath Pai, Suman Manandhar, Vasudha Devi
Research Journal of Pharmacy and Technology, 2024 - Drug delivery to the lymphatic system: The road less travelled
Annamalai Rama, Induja Govindan, Anjana A. Kailas, Thamizharasan Annadurai, Shaila Angela Lewis, Sreedhara Ranganath Pai, A. Naha
Journal of Applied Pharmaceutical Science, 2024 - Identification of potential Akt activators: a ligand and structure-based computational approach
Harish B. Kumar, Suman Manandhar, Ekta Rathi, Shama Prasada Kabekkodu, Chetan Hasmukh Mehta, Usha Yogendra Nayak, Suvarna G. Kini, K. Sreedhara Ranganath Pai
Molecular Diversity, 2024 - Influence of Ascorbic Acid on Di-(2-Ethylhexyl) Phthalate-induced Ovarian Gene Alterations in Pubertal Female Wistar Rats
Shifana Ali, Ahmed Ziyad, Karkala Sreedhara Ranganath Pai, Anju Muraleedharan, Adhithya Gopan, Raghavendra Upadhya, Raviraja N Seetharam, Kalaivani Manokaran
Journal of Pharmacology and Pharmacotherapeutics, 2024 - Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis
Chetan Hasmukh Mehta, Varalakshmi Velagacherla, Suman Manandhar, Yogendra Nayak, Sreedhara Ranganath K Pai, Shruthi Acharya, Usha Yogendra Nayak
AAPS Pharmscitech, 2024 - Design of floating formulations and antiulcer activity of Desmostachya bipinnata
Sanjay Kumar Putta, Koteshwara KB, Usha Y. Nayak, Sreedhara Ranganath Pai K, Raghuveer Pathuri, Aswatha Ram HN
AAPS Pharmscitech, 2024 - Animal models for clinical evaluation
Samyak Pandey, Sreedhara Ranganath K. Pai
Targeted Therapy for the Central Nervous System Formulation Clinical Challenges and Regulatory Strategies, 2024 - Stem Cells and Tumor-Killing Virus to Target Brain Tumor: In Pursuit to Bring a Potential Delivery Vehicle for the Central Nervous System Tumors
Vignesh Balaji E., K. Sreedhara Ranganath Pai
Current Drug Delivery, 2024 - Adipose Tissue Remodelling and Metabolic Syndrome Progression
E. Vignesh Balaji, K. Sreedhara Ranganath Pai
Advances in Biochemistry in Health and Disease, 2024 - In vitro evaluation of the antimicrobial activity of methanolic and aqueous extract of Acorus calamus L. and Tinospora cardifolia L
Shobha KL, Prathibha Maria D Almeida, Sreedhara R Pai
Research Journal of Pharmacy and Technology, 2024 - A Biochemical and Molecular Insight to Wound Healing Properties of Traditional Indian Medicines in Normal and Diabetic Rats
Sushma Prabhath, Kumar M R Bhat, K. Sreedhara R Pai, Manas Kinra, Karthik Gourishetti
Indian Journal of Pharmaceutical Education and Research, 2024 - Application of the Risk Evaluation Matrix as per USP <665> and <1665> for Evaluation of Leachables Risk from Single-Use Components Used in Biomanufacturing Determining E&L risk from single-use components can be used to build the level of extractable profiling and PERLs.
Biopharm International, 2024 - Evaluation of Antioxidant and Anticancer Activities of Memecylon umbellatum in Breast Carcinoma and Lupeol and Beta-sitosterol Quantified by HPTLC
Shilpee Chaudhary, Chandrashekar Kodangala Subraya, Sreedhara Ranganath Karkala, Vasudev Pai, Aswatha Ram Holavanna Halli Nanjundaiah, Aravinda Pai
Current Bioactive Compounds, 2024 - Effect of treadmill exercise on the liver, kidney health, and serum IL-10 levels in high-fat diet-induced obese male Wistar rats
Samreen M. Sheik, H. Madhukar Mallya, Deepak Nayak Manel, Vani Lakshmi Ramesh Iyer, Karkala Sreedhara Ranganath Pai, Varashree Bolar Suryakanth, Revathi P. Shenoy
Journal of Applied Pharmaceutical Science, 2024 - In-silico lead identification of the pan-mutant IDH1 and IDH2 inhibitors to target glioblastoma
Vignesh Balaji E, Sairaj Satarker, B. Harish Kumar, Samyak Pandey, Sumit Raosaheb Birangal, Usha Y. Nayak, K. Sreedhara Ranganath Pai
Journal of Biomolecular Structure and Dynamics, 2024 - Curcumin-sulfobutyl-ether beta cyclodextrin inclusion complex: preparation, spectral characterization, molecular modeling, and antimicrobial activity
Anne Boyina Sravani, Mangala Shenoy K., Baby Chandrika, Harish Kumar B., Suvarna G. Kini, Sreedhara Ranganatha Pai K., Shaila A. Lewis
Journal of Biomolecular Structure and Dynamics, 2024 - The fluorosis conundrum: bridging the gap between science and public health
Sachindra Kumar, Vishal Chhabra, Manmeet Mehra, Saranya K, Harish Kumar B, Smita Shenoy, Ravindra Shantakumar Swamy, Krishna Murti, K. Sreedhara Ranganath Pai, Nitesh Kumar
Toxicology Mechanisms and Methods, 2024 - Biological, pathological, and multifaceted therapeutic functions of exosomes to target cancer
VIGNESH BALAJI E, DIVYA RAMESH, MANISHA CHUNGAN SHAJU, AKSHARA KUMAR, SAMYAK PANDEY, RAKSHA NAYAK, V. ALKA, SRISHTI MUNJAL, AMIR SALIMI, K. SREEDHARA RANGANATH PAI, SHANKAR M. BAKKANNAVAR
Oncology Research, 2024 - Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer
Krishnaprasad Baby, Swastika Maity, Chetan Hasmukh Mehta, Usha Y. Nayak, Gautham G. Shenoy, Karkala Sreedhara Ranganath Pai, Kuzhuvelil B. Harikumar, Yogendra Nayak
Scientific Reports, 2023 - Identification of phytochemical as a dual inhibitor of PI3K and mTOR: a structure-based computational approach
B. Harish Kumar, Suman Manandhar, Sneha Sunil Choudhary, Keerthi Priya, Tanvi V. Gujaran, Chetan Hasmukh Mehta, Usha Yogendra Nayak, K. Sreedhara Ranganath Pai
Molecular Diversity, 2023 - PAK4 inhibition significantly potentiates Gemcitabine activity in PDAC cells via inhibition of Wnt/β-catenin, p-ERK/MAPK and p-AKT/PI3K pathways
Charudatt Samant, Ramesh Kale, Anand Bokare, Mahip Verma, K. Sreedhara Ranganath Pai, Mandar Bhonde
Biochemistry and Biophysics Reports, 2023 - A validated LC-MS/MS method for studying the pharmacokinetic interaction of Immusante® and antiviral drugs in rats
Lakavalli Mohankumar Sharath Kumar, Mohammed Mukhram Azeemuddin, Tirumalai Tulasi Ramanujam, Madhavan Vijayakumar, Uddagiri Venkanna Babu, K Sreedhara Ranganath Pai
Journal of Applied Pharmaceutical Science, 2023 - MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology
Karthik Gourishetti, Vignesh Balaji Easwaran, Youssef Mostakim, K. Sreedhara Ranganath Pai, Deepak Bhere
Biology, 2023 - A validated LC-MS/MS method for simultaneous quantification of antitubercular drugs in rat plasma and its application for a pharmacokinetic interaction study with Immusante®
Lakavalli Mohankumar Sharath Kumar, Mohammed Mukhram Azeemuddin, Krishna Chaitanya Routhu, Keerthi Priya, Uddagiri Venkanna Babu, Sreedhara Ranganath Pai
Journal of Applied Pharmaceutical Science, 2023 - BRAF gene as a potential target to attenuate drug resistance and treat cancer
Alison Celine Dcruz, Vignesh Balaji E, Suman Manandhar, Akshara Kumar, Tanvi V. Gujaran, Paniz Hedayat, K. Sreedhara Ranganath Pai
Gene Reports, 2023 - Role of Oxidative Stress in Pathophysiological Progression of Schizophrenia
Shvetank Bhatt, Tanuj Upadhyay, CR Patil, K. Sreedhara R. Pai, Dinesh Kumar Chellappan, Kamal Dua
Current Psychiatry Research and Reviews, 2023 - Current Drug Targets in Alzheimer’s Associated Memory Impairment: A Comprehensive Review
Chandrashekar K.S, Anna Mathew, Vignesh Balaji E, Sreedhara Ranganath K. Pai, Anoop Kishore, Vasudev Pai, Ramadevi Pemmireddy
CNS and Neurological Disorders Drug Targets, 2023 - Next-Generation Cell-Based Therapies to Combat Metastatic Brain Tumor
Vignesh Balaji E, Karkala Sreedhara Ranganath Pai
Recent Advances in Pharmaceutical Innovation and Research, 2023 - Role of GSK-3β Inhibitors: New Promises and Opportunities for Alzheimer's Disease
Suggala Ramya Shri, Suman Manandhar, Yogendra Nayak, K Sreedhara Ranganath Pai
Advanced Pharmaceutical Bulletin, 2023 - Phytochemical screening, proximate composition, and antihyperlipidemic activity of the barley-rich nutraceutical combination in triton X-100-induced hyperlipidemic Wistar rats
Samreen M. Sheik, Karkala Sreedhara Ranganath Pai, B. S. Mamatha, H. Madhukar Mallya, Vani Lakshmi Ramesh Iyer, Varashree Bolar Suryakanth, Deepak Nayak Manel, Pallavi Mahesh Shettigar, Revathi P. Shenoy
Journal of Applied Pharmaceutical Science, 2023 - Expediting Molecular Translational Approach of Mesenchymal Stem Cells in COVID-19 Treatment
K Sreedhara Ranganath Pai, Vignesh Balaji Easwaran, Sairaj Satarker, Tanvi V Gujaran, jeena john, Anuranjana Putiya Veedu, Krupa Thankam George, Divya Kunhi Purayil, Fathima Beegum, Anna Mathew, RJA Vibhavari, Sneha Sunil Chaudhari
Current Stem Cell Research and Therapy, 2023 - Cytotoxic effects of Chloroform-methanol extract, protein extract and various fractions of ethanolic extract of Curcuma amada rhizome on HCT116 colon cancer cell line
Vaibhav. S. Patil, Varashree B S, K. Sreedhara Ranganath Pai, Gangadhar Hari, Keerthi Priya
Research Journal of Pharmacy and Technology, 2022 - Anticancer therapeutic potential of phosphorylated galactosylated chitosan against N-nitrosodiethyl amine-induced hepatocarcinogenesis
Anushree U, Sachin Shetty, Suresh D Kulkarni, Harish Kumar B, K Sreedhara R Pai, Jesil Mathew A, Rajesh Kumar, Sanjay Bharati
Archives of Biochemistry and Biophysics, 2022 - Identification of novel TMPRSS2 inhibitors against SARS-CoV-2 infection: a structure-based virtual screening and molecular dynamics study
Suman Manandhar, K. Sreedhara Ranganath Pai, Praveen T. Krishnamurthy, Ammu V. V. V. Ravi Kiran, Garikapati Kusuma Kumari
Structural Chemistry, 2022 - Identification, virtual screening and molecular dynamic analysis of novel TMPRSS2 inhibitors from natural compound database as potential entry-blocking agents in SARS-CoV-2 therapy
Suman Manandhar, K Sreedhara Ranganath Pai, Praveen Thaggikuppe Krishnamurthy, Ammu V. V. V. Ravi Kiran, Garikapati Kusuma Kumari
Structural Chemistry, 2022 - Molecular dynamics and structure-based virtual screening and identification of natural compounds as Wnt signaling modulators: possible therapeutics for Alzheimer’s disease
Suman Manandhar, Runali Sankhe, Keerthi Priya, Gangadhar Hari, Harish Kumar B., Chetan H. Mehta, Usha Y. Nayak, K. Sreedhara Ranganath Pai
Molecular Diversity, 2022 - Development and Pharmacological assessment of dehydrozingerone gel formulation on imiquimod-induced psoriasis in mice
Gangadhar Hari, Anusha Prabhu, Chaitanyamayee Kalakota, Jeslin Johnson, Kufaila Mansoor, Rekha R Shenoy, Karkala Sreedhara Ranganath Pai, Krishnadas Nandakumar
Research Journal of Pharmacy and Technology, 2022 - Transpapillary iontophoretic delivery of resveratrol loaded transfersomes for localized delivery to breast cancer
Shivaprasad Gadag, Reema Narayan, Jayalakshmi N. Sabhahit, Gangadhar Hari, Yogendra Nayak, Karkala Sreedhara Ranganath Pai, Sanjay Garg, Usha Y. Nayak
Biomaterials Advances, 2022 - Treatments for psoriasis: A journey from classical to advanced therapies. How far have we reached?
Gangadhar Hari, Anoop Kishore, Sreedhara Ranganath Pai Karkala
European Journal of Pharmacology, 2022 - The rise of E-pharmacy in India: Benefits, challenges, and the road ahead
Indian Journal of Pharmacology, 2022 - Synthesis, Molecular Docking and Evaluation of 1,3,4-Oxadiazole-Isobenzofuran Hybrids as Antimicrobial and Anticancer Agents
Swarnagowri Nayak, Santosh L. Gaonkar, Druti Hazra, Kiran Chawla, Gangadhar Hari, K. S. R. Pai, Bharath Raja Guru, Sushruta S. Hakimane
Chemistry and Biodiversity, 2022 - Oxidative stress and female reproductive disorder: A review
KarkalaSreedhara Ranganath Pai, Kalaivani Manokaran, Pavithra Bhat, Deepak Nayak, Ravisankar Baskaran, Prabu Paramasivam, ShiekFareeth Ahmed, Keerthi Priya, VigneshE Balaji
Asian Pacific Journal of Reproduction, 2022 - Structure Based Virtual Docking and Molecular Dynamics Guided Identification of Potential Phytoconstituents from Traditionally Used Female Antifertility Plant
Keerthi Priya, Suman Manandhar, Runali Sankhe, M Manjunath Setty, UV Babu, Sreedhara Ranganath Pai
Pharmaceutical Sciences, 2022 - Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy
Swastika Maity, Manas Kinra, Madhavan Nampoothiri, Devinder Arora, K. Sreedhara Ranganath Pai, Jayesh Mudgal
Chemical Papers, 2022 - Structure-based docking, pharmacokinetic evaluation, and molecular dynamics-guided evaluation of traditional formulation against SARS-CoV-2 spike protein receptor bind domain and ACE2 receptor complex
B. Harish kumar, Suman Manandhar, Chetan H. Mehta, Usha Y. Nayak, K. Sreedhara Ranganath Pai
Chemical Papers, 2022 - Stem Cells Delivered Oncolytic Virus to Destroy Formidable Brain Tumor
Vignesh Balaji E, K. Sreedhara Ranganath Pai
Stem Cell Reviews and Reports, 2022 - Role of Brain-Gut-Microbiome Axis in Depression Comorbid with Asthma
Shvetank Bhatt, K. Sreedhara R. Pai, C. R. Patil, S. N. Manjula, S. Mohana Lakshmi
Microbiome in Inflammatory Lung Diseases, 2022 - Discovery of potential inhibitors for stat3: ligand based 3D pharmacophore, virtual screening, molecular docking, dynamic studies and in vitro evaluation
Kaviarasan Lakshmanan, Praveen T. K., Sreedhara Ranganath K. Pai, Kalirajan Rajagopal, Gowramma Byran
Journal of Biomolecular Structure and Dynamics, 2022 - A REVIEW ON PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF Syzygium caryophyllatum
Ramadevi Pemmereddy, K. S. Chandrashekar, Sreedhara Ranganath K. Pai, Vasudev Pai, Anna Mathew, B. Venkatesh Kamath
Rasayan Journal of Chemistry, 2022 - Repositioning of antidiabetic drugs for Alzheimer’s disease: possibility of Wnt signaling modulation by targeting LRP6 an in silico based study
Suman Manandhar, Keerthi Priya, Chetan H. Mehta, Usha Y. Nayak, Shama Prasada Kabekkodu, K. Sreedhara Ranganath Pai
Journal of Biomolecular Structure and Dynamics, 2022 - Implications of environmental toxicants on ovarian follicles: how it can adversely affect the female fertility?
Keerthi Priya, Manjunath Setty, Uddagiri Venkanna Babu, Karkala Sreedhara Ranganath Pai
Environmental Science and Pollution Research, 2021 - In silico-based virtual screening and molecular docking analysis of phytochemicals obtained from methanolic extract of Cleome viscosa Linn. By GC-MS method for its anticancer activity
K. Usha S. Pai, Yadav D. Bodke, Suman Manandhar, K. Sreedhara Ranganath Pai
Asian Journal of Chemistry, 2021 - Molecular modeling piloted analysis for semicarbazone derivative of curcumin as a potent Abl-kinase inhibitor targeting colon cancer
Fiona C. Rodrigues, Gangadhar Hari, K. S. R. Pai, Akhil Suresh, Usha Y. Nayak, N. V. Anilkumar, Goutam Thakur
3 Biotech, 2021 - Synthesis, Crystal Structure, Biological Evaluation, DFT Calculations and Third Order Nonlinear Optical Studies of Pyrazolines
Swarnagowri Nayak, Vinay Parol, Gangadhar Hari, K.S.R. Pai, Rajeev K. Sinha, N.K. Lokanath, Sri Ram G Naraharisetty, Santosh L. Gaonkar
Journal of Molecular Structure, 2021 - The inhibitory potency of isoxazole-curcumin analogue for the management of breast cancer: A comparative in vitro and molecular modeling investigation
Fiona C. Rodrigues, N. V. Anil Kumar, Gangadhar Hari, K. S. R. Pai, Goutam Thakur
Chemical Papers, 2021 - Correction to: e-Pharmacophore model-guided design of potential DprE1 inhibitors: synthesis, in vitro antitubercular assay and molecular modelling studies (Chemical Papers, (2021), 75, 10, (5571-5585), 10.1007/s11696-021-01743-3)
Avinash Kumar, Revathi Rajappan, Suvarna G. Kini, Ekta Rathi, Sriram Dharmarajan, K. Sreedhara Ranganath Pai
Chemical Papers, 2021 - An insight on promising strategies hoping to cure HIV-1 infection by targeting Rev protein—short review
Sahana Pai, Jayesh Mudgal, B. Venkatesh Kamath, K. Sreedhara Ranganath Pai
Pharmacological Reports, 2021 - Cleome viscosa exhibits cytotoxicity in vitro and improves tumor inhibitory properties in vivo in liquid tumor model
K Usha S Pai, Yadav D. Bodke, M Manjunath Setty, Savaliya Mihir, Keerthi Priya, K Sreedhara Ranganath Pai
Research Journal of Pharmacy and Technology, 2021 - e-Pharmacophore model-guided design of potential DprE1 inhibitors: synthesis, in vitro antitubercular assay and molecular modelling studies
Avinash Kumar, Revathi Rajappan, Suvarna G. Kini, Ekta Rathi, Sriram Dharmarajan, K. Sreedhara Ranganath Pai
Chemical Papers, 2021 - Antidepressant-like effect of dehydrozingerone from Zingiber officinale by elevating monoamines in brain: in silico and in vivo studies
Sudheer Moorkoth, N. Sai Prathyusha, Suman Manandhar, Yuanxin Xue, Runali Sankhe, K. S. R. Pai, Nitesh Kumar
Pharmacological Reports, 2021 - Ethno pharmacological properties of euphorbia thymifolia (Linn.)
Vasavi Kumblekar, Reshma Kumarachandra, Shama Prasada Kabekkodu, K. Sreedhara Ranganath Pai
Medicinal Plants, 2021 - In vitro evaluation of the antimicrobial activity of methanolic and aqueous extract of mucuna pruriens seed
Amita Shobha Rao, Shobha K L, Preethi Lavina Concessao, Gowrish Rao S, Sreedhara R Pai K
Research Journal of Pharmacy and Technology, 2021 - ABO phenotype and SARS-CoV-2 infection: Is there any correlation?
Anna Mathew, Vignesh Balaji E, Sreedhara Ranganath K. Pai, Anoop Kishore, Vasudev Pai, K.S. Chandrashekar
Infection Genetics and Evolution, 2021 - Mesoporous silica nanoparticles capped with chitosan-glucuronic acid conjugate for pH-responsive targeted delivery of 5-fluorouracil
Reema Narayan, Shivaprasad Gadag, Rajeev J. Mudakavi, Sanjay Garg, Ashok M. Raichur, Yogendra Nayak, Suvarna G. Kini, Karkala Sreedhara Ranganath Pai, Usha Y. Nayak
Journal of Drug Delivery Science and Technology, 2021 - Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy
Reema Narayan, Shivaprasad Gadag, Sri Pragnya Cheruku, Ashok M. Raichur, Candace Minhthu Day, Sanjay Garg, Suman Manandhar, Karkala Sreedhara Ranganath Pai, Akhil Suresh, Chetan Hasmukh Mehta, Yogendra Nayak, Nitesh Kumar, Usha Yogendra Nayak
Carbohydrate Polymers, 2021 - Protective role of caffeic acid in cognitive dysfunction and oxidative stress induced by colchicine in rats
Surubhotla Raviteja, Suman Manandhar, Keerthi Priya, Gangadhar Hari, K Sreedhara Ranganath Pai
Indian Journal of Pharmaceutical Education and Research, 2021 - Virtual structure-based docking, WaterMap, and molecular dynamics guided identification of the potential natural compounds as inhibitors of protein-tyrosine phosphatase 1B
Manasa B, Suman Manandhar, Gangadhar Hari, Keerthi Priya, Harish Kumar B, K. Sreedhara Ranganath Pai
Journal of Molecular Structure, 2021 - Tumour suppression through modulation of neprilysin signaling: A comprehensive review
Runali Sankhe, Sreedhara Ranganath K. Pai, Anoop Kishore
European Journal of Pharmacology, 2021 - Repurposing of existing FDA approved drugs for Neprilysin inhibition: An in-silico study
Runali Sankhe, Ekta Rathi, Suman Manandhar, Avinash Kumar, Sreedhara Ranganath K Pai, Suvarna G Kini, Anoop Kishore
Journal of Molecular Structure, 2021 - Clinical protocols for nanopharmacokinetics assessment
Suman Manandhar, Runali Sankhe, B. Harish Kumar, K. Sreedhara Ranganath Pai
Nano Pharmacokinetics and Theranostics Advancing Cancer Therapy, 2021 - Targeting Molecular and Cellular Mechanisms in Chronic Obstructive Pulmonary Disease
Shvetank Bhatt, Jovita Kanoujia, A. N. Nagappa, K. Sreedhara R. Pai
Targeting Cellular Signalling Pathways in Lung Diseases, 2021 - Effect of Mucuna pruriens (Linn.) on global cerebral Ischemia-induced motor incoordination
Vanishri S. Nayak, KSR Pai, Sunil S. Nayak, Nitesh Kumar, Hemalatha Bangera
Tropical Journal of Pharmaceutical Research, 2021 - Protective effects of gossypin in colchicine-induced cognitive dysfunction and oxidative damage in rats
Research Journal of Pharmacy and Technology, 2020 - Aberrant canonical Wnt signaling: Phytochemical based modulation
Suman Manandhar, Shama Prasada Kabekkodu, K. Sreedhara Ranganath Pai
Phytomedicine, 2020 - Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance
Swastika Maity, K. Sreedhara Ranganath Pai, Yogendra Nayak
Pharmacological Reports, 2020 - In vitro and in vivo evaluation of anticancer properties of clerodendrum indicum (L.) kuntze in colon cancer
Keerthi Priya, M Manjunath Setty, K Sreedhara Ranganath Pai
Research Journal of Pharmacy and Technology, 2020 - Evidence for anticancer properties of honey with emphasis on mechanistic overview
Avinash Kundadka Kudva, Suresh Rao, Pratima Rao, Michael L.J. Pais, Mohammed Adnan, Karkala Sreedhara Ranganath Pai, Manjeshwar Shrinath Baliga
Functional Foods in Cancer Prevention and Therapy, 2020 - Neuromodulatory potential of phenylpropanoids; para-methoxycinnamic acid and ethyl-p-methoxycinnamate on aluminum-induced memory deficit in rats
Samita Rijal, Nilanjan Changdar, Manas Kinra, Ayush Kumar, Madhavan Nampoothiri, Devinder Arora, Rekha R. Shenoy, K. Sreedhara Ranganath Pai, Alex Joseph, Jayesh Mudgal
Toxicology Mechanisms and Methods, 2019 - Targeting HIV-TB coinfection by developing novel piperidin-4-substituted imines: Design, synthesis, in vitro and in silico studies
Avinash Kumar, Rajappan Revathi, Dharmarajan Sriram, Francesca Curreli, Asim K. Debnath, K. Sreedhara Pai, Suvarna G. Kini
Archiv Der Pharmazie, 2019 - Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice
Puspita Sahu, Jayesh Mudgal, Devinder Arora, Manas Kinra, Sanchari Basu Mallik, Chamallamudi Mallikarjuna Rao, K. S. R. Pai, Madhavan Nampoothiri
Psychopharmacology, 2019 - Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms
Prashant B. Nigade, Jayasagar Gundu, K. Sreedhara Pai, Kumar V. S. Nemmani, Rashmi Talwar
Xenobiotica, 2019 - Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats
Manas Kinra, Devinder Arora, Jayesh Mudgal, K.S.R. Pai, Chamallamudi Mallikarjuna Rao, Madhavan Nampoothiri
Pharmacology, 2019 - Caesalpinia bonduc linn extracts exhibit hepatoprotective effect on hepg2 cells against paracetamol by up-regulating glutathione related genes
Journal of Krishna Institute of Medical Sciences University, 2019 - Influence of traditional medicines on the activity of keratinocytes in wound healing: An in-vitro study
Sushma R. Kotian, Kumar M. R. Bhat, Divya Padma, K. Sreedhara R. Pai
Anatomy and Cell Biology, 2019 - Design, synthesis, biological evaluation and in silico studies of few novel 2-substituted benzothiazole derivatives as potential EGFR inhibitors
Muhammad Mubeen, Suvarna Ganesh Kini, Avinash Kumar, Karkala Sreedhara Ranganath Pai
Letters in Drug Design and Discovery, 2019 - Effect of sodium arsenate administration on the status of cellular antioxidant enzyme activity and carbohydrate metabolism in isolated enterocytes of mus musculus
Ecology Environment and Conservation, 2019 - In vitro antibacterial and antifungal activities of aqueous and ethanolic leaf extracts of acacia auriculiformis
Amita Shobha Rao, Shobha Kl, Manjunath S Shetty, Sreedhara R Pai K
Asian Journal of Pharmaceutical and Clinical Research, 2018 - Antimicrobial activity of aqueous and ethanolic leaf extracts of anacardium occidentale
Shobha Kl, Amita Shobha Rao, Pai Ksr, Sujatha Bhat
Asian Journal of Pharmaceutical and Clinical Research, 2018 - The Role of Natural Medicines on Wound Healing: A Biomechanical, Histological, Biochemical and Molecular Study
Kotian Sushma, Bhat Kumar, Pai Sreedhara, Nayak Jayakrishna, Souza Anne, Gourisheti Karthik, Padma Divya
Ethiopian Journal of Health Sciences, 2018 - Amelioration of arsenic-induced oxidative stress in CHO cells by Ixora coccinea flower extract
S. A. Salmataj, Shobha U. Kamath, V. Ramachandra Murty, Sreedhara Ranganath Pai
3 Biotech, 2018 - N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats
Joylee Fernandes, Jayesh Mudgal, Chamallamudi Mallikarjuna Rao, Devinder Arora, Sanchari Basu Mallik, K. S. R. Pai, Madhavan Nampoothiri
Toxicology Mechanisms and Methods, 2018 - Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models
Prashant B. Nigade, Jayasagar Gundu, K. Sreedhara Pai, Kumar V. S. Nemmani
European Journal of Drug Metabolism and Pharmacokinetics, 2018 - Evaluation of covariates using population pharmacokinetics approach for dose individualization of levothyroxine in patients with post thyroidectomy and131i ablation therapy
Rajesh Kumar, Mukhyaprana Prabhu, Sreedhar R Pai, Vasudev Shenoy
Research Journal of Pharmacy and Technology, 2018 - Modulatory role of mucuna pruriens against aluminium fluoride induced neuronal and behavioural alterations in rats
Vanishri S Nayak, Nitesh Kumar, Antony Sylvan DSouza, Sunil S Nayak, KSR Pai
Journal of Clinical and Diagnostic Research, 2018 - Experimentally induced arsenate toxicity attenuated by ixora coccinea flower extract in IEC-6 cells
Asian Journal of Microbiology Biotechnology and Environmental Sciences, 2018 - Design, synthesis, antioxidant and anticancer activity of novel schiff’s bases of 2-amino benzothiazole
Saipriya Saipriya D, Arun Prakash, Suvarna G Kini, Varadaraj Bhatt G, K Sreedhara Ranganath Pai, Subhankar Biswas, Mohammed Shameer K
Indian Journal of Pharmaceutical Education and Research, 2018 - Structural Elucidation of Alkaloids from Aerial Parts of Rivea hypocrateriformis and Their Antihemolytic and Cytotoxic Activity
S. S. Godipurge, J. S. Biradar, N. J. Biradar, H. P. Shivarudrappa, S. Yallappa, B. S. Hungund, K. Sreedhara Ranganath Pai
Chemistry of Natural Compounds, 2018 - Sodium valproate enhances doxorubicin-induced cognitive dysfunction in Wistar rats
Thaneshwar Verma, Sanchari Basu Mallik, G.V. Ramalingayya, Pawan G. Nayak, Anoop Kishore, K. Sreedhara R. Pai, Krishnadas Nandakumar
Biomedicine and Pharmacotherapy, 2017 - Bisindole-oxadiazole hybrids, T3P ® -mediated synthesis, and appraisal of their apoptotic, antimetastatic, and computational Bcl-2 binding potential
Pooja R. Kamath, Manu M. Joseph, Abdul Ajees Abdul Salam, Sreelekha T. Therakathinal, Dhanya Sunil, Subhankar Biswas, Karkala Sreedhara Ranganath Pai
Journal of Biochemical and Molecular Toxicology, 2017 - Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice
Prashant B. Nigade, Jayasagar Gundu, K. Sreedhara Pai, Kumar V. S. Nemmani
European Journal of Drug Metabolism and Pharmacokinetics, 2017 - Rose apple (syzygium jambos (L.) alston)
Manjeshwar Shrinath Baliga, Karkala Shreedhara Ranganath Pai, Elroy Saldanha, Vikram Singh Ratnu, Rashmi Priya, Mohammed Adnan, Taresh S. Naik
Fruit and Vegetable Phytochemicals Chemistry and Human Health Second Edition, 2017 - Promising anticancer activities of Justicia simplex D. Don. in cellular and animal models
Litty Joseph, Jesil Mathew Aranjani, K. Sreedhara Ranganath Pai, K.K. Srinivasan
Journal of Ethnopharmacology, 2017 - Anticancer activity of stem bark extract and fractions of Wrightia tinctoria in transplantable tumors in mice
Shilpee Chaudhary, Manganahalli Manjunath Setty, Karkala Sreedhara Ranganath Pai
Advanced Science Letters, 2017 - Screening of anticancer activity of selected medicinal plants indigenous to Western Ghats: Argyreia nervosa, Memecylon malabaricum and Memecylon umbellatum
Shilpee Chaudhary, Kodangala Subraya Chandrashekar, Karkala Sreedhara Ranganath Pai, M. M Setty, Raviraj Anand Devkar, Neetinkumar Dnyanoba Reddy, Subhankar Biswas
Advanced Science Letters, 2017 - Review of pharmacokinetics of levothyroxine, with specific focus on patient with thyroid carcinoma
Journal of Global Pharma Technology, 2017 - The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia
Vanishri S. Nayak, Nitesh Kumar, Antony S. D’Souza, Sunil S. Nayak, Sri P. Cheruku, K. Sreedhara Ranganath Pai
Neuroreport, 2017 - Bulbophyllum sterile petroleum ether fraction induces apoptosis in vitro and ameliorates tumor progression in vivo
Subhankar Biswas, Rashmi Pardeshi, Neetinkumar D. Reddy, Muhammed Haneefa Shoja, Pawan G. Nayak, M. Manjunath Setty, K. Sreedhara R. Pai
Biomedicine and Pharmacotherapy, 2016 - Evaluation of Ceiba pentandra (L.) Gaertner bark extracts for in vitro cytotoxicity on cancer cells and in vivo antitumor activity in solid and liquid tumor models
Ravishankar Kumar, Nitesh Kumar, Grandhi V. Ramalingayya, Manganahalli Manjunath Setty, Karkala Sreedhara Rangnath Pai
Cytotechnology, 2016 - N′-((2-(6-bromo-2-oxo-2 H -chromen-3-yl)-1 H -indol-3-yl)methylene)benzohydrazide as a probable Bcl-2/Bcl-xL inhibitor with apoptotic and anti-metastatic potential
European Journal of Medicinal Chemistry, 2016 - Synthesis, spectroscopic and anti tumor studies on copper(II) complex of orthohydroxypropiophenoneisonicotinoylhydrazone
G.N. Ramesh, B. Prathima, Y. Subba Rao, Y.P. Reddy, K.S.R. Pai, A. Varada Reddy
Arabian Journal of Chemistry, 2016 - Assessment of the in vitro cytotoxicity and in vivo anti-tumor activity of the alcoholic stem bark extract/fractions of Mimusops elengi Linn.
Harish Kumar, Mihir Savaliya, Subhankar Biswas, Pawan G. Nayak, Naseer Maliyakkal, M. Manjunath Setty, Karthik Gourishetti, K. Sreedhara Ranganath Pai
Cytotechnology, 2016 - Urinary tract infection treatment pattern of elderly patients in a tertiary hospital setup in south India: A prospective study
Ramanath Katta Venkatesh, Mukhyaprana M Prabhu, Krishnadas Nandakumar, K Sreedhara R Pai
Journal of Young Pharmacists, 2016 - Novel Indole-Quinazolinone Based Amides as Cytotoxic Agents
Nikhila Gokhale, Naveen Panathur, Udayakumar Dalimba, Pawan G. Nayak, K. Sreedhar Ranganath Pai
Journal of Heterocyclic Chemistry, 2016 - Monitoring of adverse reactions in geriatric south Indian patients in a tertiary care teaching hospital: A prospective study
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2016 - Hepatoprotective activity of aqueous extract of caesalpinia bonduc against CCl4 induced chronic hepatotoxicity
International Journal of Pharmacy and Pharmaceutical Sciences, 2016 - 1,2,3-Triazolyl pyrazole derivatives as anti-cancer agents: Biological evaluation and molecular docking
Der Pharma Chemica, 2016 - Design, synthesis, characterization of some new 1,2,3-triazolyl chalcone derivatives as potential anti-microbial, anti-oxidant and anti-cancer agents via a Claisen-Schmidt reaction approach
Manjunatha Bhat, Nagaraja G. K., Divyaraj P., Harikrishna N., Sreedhara Ranganath Pai K., Subhankar Biswas, Peethamber S. K.
Rsc Advances, 2016 - Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma
Shilpee Chaudhary, Kodangala Subraya Chandrashekar, Karkala Sreedhara Ranganath Pai, Manganahalli Manjunath Setty, Raviraj Anand Devkar, Neetinkumar Dnyanoba Reddy, Muhammed Haneefa Shoja
BMC Complementary and Alternative Medicine, 2015 - Some new indole-coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies
Pooja R. Kamath, Dhanya Sunil, A. Abdul Ajees, K.S.R. Pai, Shubhankar Das
Bioorganic Chemistry, 2015 - Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents
Dinesha, Shivapura Viveka, Bolli Keerthi Priya, K. Sreedhara Ranganath Pai, Shivalingegowda Naveen, Neratur K. Lokanath, Gundibasappa Karikannar Nagaraja
European Journal of Medicinal Chemistry, 2015 - Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents
Suvarna Ganesh Kini, Revathi Rajappan, Venkatesha Perumal Ramachandran, Karkala Sreedhara Ranganath Pai, Arunkumar Govindakarnavar, Sriram Dharmarajan
Drug Design Development and Therapy, 2015 - In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma
Neetinkumar D. Reddy, M.H. Shoja, B.S. Jayashree, Pawan G. Nayak, Nitesh Kumar, V. Ganga Prasad, K. Sreedhara R. Pai, C. Mallikarjuna Rao
Chemico Biological Interactions, 2015 - Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agents
U. Sankappa Rai, A.M. Isloor, P. Shetty, K.S.R. Pai, H.K. Fun
Arabian Journal of Chemistry, 2015 - Effects of withania somnifera and tinospora cordifolia extracts on the side population phenotype of human epithelial cancer cells: Toward targeting multidrug resistance in cancer
Naseer Maliyakkal, Asmy Appadath Beeran, Sai A. Balaji, Nayanabhirama Udupa, Sreedhara Ranganath Pai, Annapoorni Rangarajan
Integrative Cancer Therapies, 2015 - Design, synthesis, antioxidant and anticancer activity of novel pyrazole derivatives
Der Pharma Chemica, 2015 - Biomechanical, biochemical and histological evidences for wound healing properties of Indian traditional medicines
International Journal of Pharmacy and Pharmaceutical Sciences, 2015 - Molecular docking, pharmacophore modeling and 3D-QSAR approach on a series of piperidone derivatives as potential anticancer agents by targeting the enzyme VEGFR-2 tyrosine kinase
Der Pharma Chemica, 2015 - Hepatoprotective role of Caesalpenia bonduc: A histopathological and biochemical study
Suhani Sumalatha
Journal of Clinical and Diagnostic Research, 2014 - Retraction:In vitro cytotoxic and apoptotic effect of Mimusops elengi Linn. methanolic bark extract
Harish Kumar, K. Sreedhara Ranganath Pai, Naseer Maliyakkal, Savaliya Mihir, Charanjeet Singh
Biomedicine and Preventive Nutrition, 2014 - Beneficial effect of Cissus quadrangularis linn. on osteopenia associated with streptozotocin-induced type 1 diabetes mellitus in male Wistar rats
Srinivasa Rao Sirasanagandla, Sreedhara Ranganath Pai Karkala, Bhagath Kumar Potu, Kumar M.R. Bhat
Advances in Pharmacological Sciences, 2014 - Exploration of antioxidant and antimicrobial potential of methanolic extract of root stock of Premna herbacea
Isha Dhamija, Nitesh Kumar, K.S.R. Pai, M. Manjunath Setty, Sandeep Kumar, Asim K. Jana
Bangladesh Journal of Pharmacology, 2014 - Cytotoxic and apoptotic activities of extracts of withania somnifera and tinospora cordifolia in human breast cancer cells
International Journal of Applied Research in Natural Products, 2013 - Preventive role of Emblica offcinalis and Cissus quadrangularis on bone loss in osteoporosis
International Journal of Pharmacy and Pharmaceutical Sciences, 2013 - Preventive role of Emblica offcinalis and Cissus quadrangularis on bone loss in osteoporosis
International Journal of Pharmacy and Pharmaceutical Sciences, 2013 - Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts
Pawan G Nayak, Piya Paul, Punit Bansal, Nampurath Gopalan Kutty, Karkala Sreedhara Ranganath Pai
Journal of Pharmacy and Pharmacology, 2013 - Corrigendum to In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells [Arabian Journal of Chemistry 6(1) (2013) 25-33]
Dhanya Sunil, Arun M. Isloor, Prakash Shetty, Pawan G. Nayak, K.S.R. Pai, Hoong-Kun Fun
Arabian Journal of Chemistry, 2013 - Preliminary evaluation of in vitro cytotoxicity and in vivo antitumor activity of Premna herbacea Roxb. in Ehrlich ascites carcinoma model and Dalton's lymphoma ascites model
Isha Dhamija, Nitesh Kumar, S.N. Manjula, Vipan Parihar, M. Manjunath Setty, K.S.R. Pai
Experimental and Toxicologic Pathology, 2013 - Synthesis, characterization, anticancer, and antioxidant activity of some new thiazolidin-4-ones in MCF-7 cells
Arun M. Isloor, Dhanya Sunil, Prakash Shetty, Shridhar Malladi, K. S. R. Pai, Naseer Maliyakkl
Medicinal Chemistry Research, 2013 - In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells. 1st Cancer Update.
Dhanya Sunil, Arun M. Isloor, Prakash Shetty, Pawan G. Nayak, K.S.R. Pai
Arabian Journal of Chemistry, 2013 - Camellia sinensis (tea) in the prevention of UV-induced carcinogenesis: A mechanistic overview
Princy Louis Palatty, Manjeshwar Shrinath Baliga, Anatappa Govindaraju Rajeev, Raghavendra Haniadka, Harshith P. Bhat, Karkala Shreedhara Ranganath Pai, Manoj P. Rai, Nikku Mathew Geevarughese, Rajesh Arora
Bioactive Dietary Factors and Plant Extracts in Dermatology, 2013 - Click Chemistry Approach for Bis-Chromenyl Triazole Hybrids and Their Antitubercular Activity
Reshma J. Naik, Manohar V. Kulkarni, K. Sreedhara Ranganath Pai, Pawan G. Nayak
Chemical Biology and Drug Design, 2012 - Pharmacophore modeling of delta and MU receptors and synthesis of enkephalines with D-[Leu] 5 C-terminal modification as delta selective agonists
International Journal of Pharmacy and Technology, 2012 - Anticancer activity of Berberis aristata in Ehrlich ascites carcinoma-bearing mice: A preliminary study
K.S.R. Pai, P. Srilatha, Kumar Suryakant, M. Manjunath Setty, Pawan G. Nayak, C. Mallikarjuna Rao, M.S. Baliga
Pharmaceutical Biology, 2012 - Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats
Girish R. Bankar, Pawan G. Nayak, Punit Bansal, Piya Paul, K.S.R. Pai, Rajeev K. Singla, Varadaraj G. Bhat
Journal of Ethnopharmacology, 2011 - Design and synthesis of certain mesoionic sydnonyl styrylketones as potential nonsteroidal antiinflammatory agents
Shreenivas Deshpande, Karkala Pai, Ranganath Pai
Arzneimittel Forschung Drug Research, 2011 - Free radical scavenging activity of extracts of young prop roots of ficus bengalensis
Pharmacologyonline, 2010 - Synthesis, antitumor, and DNA binding behavior of novel 4-(2-Hydroxyquinolin-3-yl)-6-Phenyl-5, 6 dihydropyrimidin derivatives in aqueous medium
Devappa S. Lamani, K. R. Venugopala Reddy, H. S. Bhojya Naik, K. S. R. Pai, Ravishankar Kumar, Fasiulla, H. R. Prakash Naik, L. R. Naik
Nucleosides Nucleotides and Nucleic Acids, 2010 - Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives
Arun M. Isloor, Balakrishna Kalluraya, K. Sridhar Pai
European Journal of Medicinal Chemistry, 2010 - Evaluation of potato tuber carboxypeptidase inhibitor with standard anti-thrombotic drugs in various thrombosis models
International Journal of Pharma and Bio Sciences, 2010 - Synthesis, structure, electrochemistry and spectral characterization of (d-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice
M.P. Sathisha, Srinivasa Budagumpi, Naveen V. Kulkarni, Gurunath S. Kurdekar, V.K. Revankar, K.S.R. Pai
European Journal of Medicinal Chemistry, 2010 - Antitumor and antioxidant activity of Polyalthia longifolia stem bark ethanol extract
Santhepete N. Manjula, Mruthunjaya Kenganora, Vipan K. Parihar, Suryakant Kumar, Pawan G. Nayak, Nitesh Kumar, Karkala Sreedhara Ranganath Pai, Chamallamudi Mallikarjuna Rao
Pharmaceutical Biology, 2010 - Growth promoting potential of Ficus bengalensis root extracts in immature female rats
I.S.R. Nidhiya, K.S.R. Pai, C. Mallikarjuna Rao
Pharmaceutical Biology, 2009 - Synthesis and antitumor studies on novel Co(II), Ni(II) and Cu(II) metal complexes of bis(3-acetylcoumarin)thiocarbohydrazone
M.P. Sathisha, Ullas N. Shetti, V.K. Revankar, K.S.R. Pai
European Journal of Medicinal Chemistry, 2008 - Synthesis, structure, electrochemistry, and spectral characterization of bis-isatin thiocarbohydrazone metal complexes and their antitumor activity against ehrlich ascites carcinoma in Swiss Albino mice
M. P. Sathisha, V. K. Revankar, K. S. R. Pai
Metal Based Drugs, 2008 - Synthesis, docking and anti-tumor activity of β-L-1,3-thiazolidine pyrimidine nucleoside analogues
Shimoga Nagaraj Sriharsha, Karkala Sreedhara Ranganath Pai, Suhas, Sheena Shashikanth, Kandigere Ramaiah Prabhu
Medicinal Chemistry, 2007 - Synthesis and biological evaluation of benzofuran incorporated benzodiazepines
Indian Journal of Heterocyclic Chemistry, 2005 - Synthesis and pharmacological screening of some novel naphtho [2,1-b] furo-pyrazolines, isoxazoles and isoxazolines
Indian Journal of Pharmaceutical Sciences, 2001 - Angiotensin converting enzyme inhibitors from ripened and unripened bananas
Current Science, 1999
RECENT SCHOLAR PUBLICATIONS
- Targeting glioblastoma with HDAC inhibitors: insights into hydroxamic acid-based therapeutic strategies
P Pai, I Das, Y Reddy, BS Venkidesh, P Bhandari, M Madalageri, ...
Acta Neuropathologica Communications 14 (1), 9 , 2026
2026
Citations: 1 - Targeting P2X7 receptor/NLRP1 inflammasome axis and gut dysbiosis: A mechanistic review of pyroptosis in metabolic inflammation
K Atchou, M Madalageri, S Manandhar, KSR Pai
Experimental and Molecular Pathology 146, 105041 , 2026
2026 - In Silico and In Vitro Evaluation of Risedronate as a DKK1 Antagonist: Implications for Neuroprotection through DKK1–LRP6 Modulation
S Manandhar, A Govindula, K Atchou, A Nassar, SP Kabekkodu, KSR Pai
European Journal of Pharmacology, 178971 , 2026
2026 - Mannose-functionalized liposomal delivery of levamisole and lipopolysaccharide enhances therapeutic responses through tumor-associated macrophage modulation in colon cancer
SP Cheruku, RJA Vibhavari, V Rao, D Gopalan, A Eedara, Y Chandra, ...
International Journal of Biological Macromolecules, 152336 , 2026
2026 - Computational identification of marine-derived inhibitors of Cyclophilin D and Protease-Activated Receptor-1 for the treatment of ischemic disease
V Sadashivanavar, M Madalageri, R Kinnal, K Nandakumar, R Verma, ...
Journal of Molecular Graphics and Modelling, 109329 , 2026
2026 - Integrative gene target mapping, RNA sequencing, in silico molecular docking, ADMET profiling and molecular dynamics simulation study of marine derived molecules for type 1 …
B Vastrad, S Pattanashetti, V Sadashivanavar, KSR Pai, C Vastrad
Molecular Diversity, 1-77 , 2026
2026
Citations: 1 - Quantum Dot Localized Surface Plasmon Resonance Biomedical Applications
E Vignesh Balaji, KSR Pai
Functional Quantum Dots: Synthesis, Modification, and Biomedical … , 2026
2026 - In silico screening of selected coumarins and Polyphenols to treat Non-small cell lung cancer
S Maity, J Aakriti, NVA Kumar, K Baby, UY Nayak, KSR Pai, Y Nayak
Research Journal of Pharmacy and Technology 18 (12), 6016-6020 , 2025
2025 - Antimicrobial Potential of Aqueous and Ethanolic Extracts of Fruits of Embelia ribes, Rhizomes of Nardostachys jatamansi, and Stolons of Picrorhiza kurroa: An In vitro …
KL Shobha, PMD Almeida, KSR Pai
Journal of Pure & Applied Microbiology 19 (4) , 2025
2025 - Structural insights of AKT and its activation mechanism for drug development
BH Kumar, SP Kabekkodu, KSR Pai
Molecular Diversity 29 (6), 5443-5463 , 2025
2025
Citations: 33 - Computational screening and molecular dynamics of natural compounds targeting the SH2 domain of STAT3: A multitarget approach using network pharmacology
S Kumar, BH Kumar, R Nayak, S Pandey, N Kumar, KSR Pai
Molecular Diversity 29 (6), 5607-5633 , 2025
2025
Citations: 17 - An in silico drug repurposing approach to identify HDAC1 inhibitors against glioblastoma
A Gopinathan, R Sankhe, E Rathi, T Kodi, R Upadhya, KSR Pai, ...
Journal of Biomolecular Structure and Dynamics 43 (17), 9776-9789 , 2025
2025
Citations: 14 - Neprilysin regulates the progression of glioblastoma: an in-vitro study using siRNA mediated gene silencing and HDAC1 mediated upregulation of neprilysin in U87 MG cells
A Gopinathan, R Sankhe, R Upadhya, KSR Pai, A Kishore
Molecular and Cellular Biochemistry 480 (11), 5671-5683 , 2025
2025
Citations: 1 - Integrative Multi-Omics and In Silico Computational Analysis Revealed, Marine-Derived Compounds as Potential Therapeutics Targeting Key Regulatory Genes in Rheumatoid Arthritis
BM Vastrad, S Pattanashetti, V Sadashivanavar, KSR Pai, C Vastrad
2025 - Novel pyridine and 1, 3, 4-oxadiazole-linked 1, 3-thiazole hybrids: Synthesis, anticancer evaluation, and computational insights
R Manjunath, M Padmapriya, LG Santosh
Journal of Molecular Structure, 144465 , 2025
2025
Citations: 2 - In silico drug repurposing in non-small cell lung cancer by docking and molecular dynamic simulations for epidermal growth factor receptor allosteric site inhibition
S Maity, MP Vithalkar, K Baby, UY Nayak, KSR Pai, Y Nayak
Journal of Applied Pharmaceutical Science 15 (11), 039-049 , 2025
2025 - Quinazoline-oxadiazole hybrids: Synthesis, SC-XRD, Hirshfeld surface analysis and computational investigations
YN Nayak, D Dwarakanath, KK Harish, SR Pai, M Madegowda, ...
Journal of Molecular Structure, 144212 , 2025
2025 - Exploring acenocoumarol and silodosin in non-small cell lung cancer: Insights into EGFR-linked signaling mechanisms
S Maity, K Baby, BH Byregowda, MP Vithalkar, UY Nayak, KSR Pai, ...
F1000Research 13, 1398 , 2025
2025 - Bioinformatics Analysis Screened and Identified Key Genes, miRNAs and TFs as Potential Biomarkers for Progression of Rheumatoid Arthritis
B Vastrad, S Pattanashetti, V Sadashivanavar, KSR Pai, C Vastrad
2025 - Role of Wnt/beta-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors (vol. 729, 150348, 2024)
C Samant, R Kale, K Pai, S Ranganath, K Nandakumar, M Bhonde
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 778 , 2025
2025
MOST CITED SCHOLAR PUBLICATIONS
- Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma
S Chaudhary, KS Chandrashekar, KSR Pai, MM Setty, RA Devkar, ...
BMC complementary and alternative medicine 15 (1), 50 , 2015
2015
Citations: 169 - Synthesis and antitumor studies on novel Co (II), Ni (II) and Cu (II) metal complexes of bis (3-acetylcoumarin) thiocarbohydrazone
MP Sathisha, UN Shetti, VK Revankar, KSR Pai
European journal of medicinal chemistry 43 (11), 2338-2346 , 2008
2008
Citations: 136 - Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agents
US Rai, AM Isloor, P Shetty, KSR Pai, HK Fun
Arabian Journal of Chemistry 8 (3), 317-321 , 2015
2015
Citations: 119 - Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats
GR Bankar, PG Nayak, P Bansal, P Paul, KSR Pai, RK Singla, VG Bhat
Journal of ethnopharmacology 134 (1), 50-54 , 2011
2011
Citations: 119 - Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy
R Narayan, S Gadag, SP Cheruku, AM Raichur, CM Day, S Garg, ...
Carbohydrate polymers 261, 117893 , 2021
2021
Citations: 101 - Some new indole–coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies
PR Kamath, D Sunil, AA Ajees, KSR Pai, S Das
Bioorganic Chemistry 63, 101-109 , 2015
2015
Citations: 96 - Synthesis, structure, electrochemistry, and spectral characterization of bis‐isatin thiocarbohydrazone metal complexes and their antitumor activity against Ehrlich ascites …
MP Sathisha, VK Revankar, KSR Pai
Metal‐Based Drugs 2008 (1), 362105 , 2008
2008
Citations: 90 - Implications of environmental toxicants on ovarian follicles: how it can adversely affect the female fertility?
K Priya, M Setty, UV Babu, KSR Pai
Environmental Science and Pollution Research 28 (48), 67925-67939 , 2021
2021
Citations: 82 - Preliminary evaluation of in vitro cytotoxicity and in vivo antitumor activity of Premna herbacea Roxb. in Ehrlich ascites carcinoma model and Dalton's lymphoma ascites model
I Dhamija, N Kumar, SN Manjula, V Parihar, MM Setty, KSR Pai
Experimental and Toxicologic Pathology 65 (3), 235-242 , 2013
2013
Citations: 81 - Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy
S Maity, M Kinra, M Nampoothiri, D Arora, KSR Pai, J Mudgal
Chemical papers 76 (3), 1271-1283 , 2022
2022
Citations: 79 - Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance
S Maity, KSR Pai, Y Nayak
Pharmacological Reports 72 (4), 799 , 2020
2020
Citations: 76 - Synthesis, characterization, anticancer, and antioxidant activity of some new thiazolidin-4-ones in MCF-7 cells
AM Isloor, D Sunil, P Shetty, S Malladi, KSR Pai, N Maliyakkl
Medicinal Chemistry Research 22 (2), 758-767 , 2013
2013
Citations: 72 - Role of GSK-3β inhibitors: new promises and opportunities for Alzheimer’s disease
SR Shri, S Manandhar, Y Nayak, KSR Pai
Advanced pharmaceutical bulletin 13 (4), 688 , 2023
2023
Citations: 66 - Molecular dynamics and structure-based virtual screening and identification of natural compounds as Wnt signaling modulators: possible therapeutics for Alzheimer’s disease
S Manandhar, R Sankhe, K Priya, G Hari, H Kumar B, CH Mehta, ...
Molecular Diversity 26 (5), 2793-2811 , 2022
2022
Citations: 61 - Antitumor and antioxidant activity of Polyalthia longifolia stem bark ethanol extract
SN Manjula, M Kenganora, VK Parihar, S Kumar, PG Nayak, N Kumar, ...
Pharmaceutical biology 48 (6), 690-696 , 2010
2010
Citations: 60 - In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells: 1st cancer update
D Sunil, AM Isloor, P Shetty, PG Nayak, KSR Pai
Arabian Journal of Chemistry 6 (1), 25-33 , 2013
2013
Citations: 59 - Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice
P Sahu, J Mudgal, D Arora, M Kinra, SB Mallik, CM Rao, KSR Pai, ...
Psychopharmacology 236 (6), 1829-1838 , 2019
2019
Citations: 55 - The role of natural medicines on wound healing: a biomechanical, histological, biochemical and molecular study
S Kotian, K Bhat, S Pai, J Nayak, A Souza, K Gourisheti, D Padma
Ethiopian journal of health sciences 28 (6), 759 , 2018
2018
Citations: 54 - Cytotoxic and apoptotic activities of extracts of Withania somnifera and Tinospora cordifolia in human breast cancer cells.
N Maliyakkal, N Udupa, KSR Pai, A Rangarajan
2013
Citations: 53 - Synthesis and pharmacological screening of some novel naphtho [2, 1-b] furo-pyrazolines, isoxazoles and isoxazolines
HM Vagdevi, KP Latha, VP Vaidya, MLV Kumar, KSR Pai
Indian journal of pharmaceutical sciences 63 (4), 286-291 , 2001
2001
Citations: 51
