Oxana Klementieva
@lu.se
Lunds universitet
Scopus Publications
- ATR-FTIR analysis of temperature-dependent changes in extracellular vesicles and associated released components
Kar-Yan Su, Oxana Klementieva, Wai-Leng Lee, Siong Fong Sim, Laura-Madalina Lixandru, Carmenza Spadafora, Mihai Brebu, Elena Stoleru, Mohammad Mehedi Hasan, Pascale V. Guillot, Radu Ionescu
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2026
) from the ATR-FTIR spectra led to clear discrimination between the epithelial cells (EPI) EVs on one hand, and the hepatocellular cancer cells (HEP-G2) EVs and the embryotic kidney cells (HEK293) EVs on the other hand. We were able to detect signals corresponding to EVs after separating them from PBS and subjecting them to blow-drying without heat, followed by examination of alterations upon heat treatment. The fingerprint of compounds released by EVs after disruption at 60 °C was not detected under blow-drying conditions. However, when the filtrate was freeze-dried, the signal after disruption through heating at 60 °C was preserved, suggesting the importance of freeze-drying for maintaining compounds integrity. The comparative ATR-FTIR analysis of EVs and their released compounds revealed distinct molecular compositions, with EVs enriched in phospholipids and proteins, while the filtrates consisted of degraded fractions containing more homogeneous molecules. - Disruption of CSF-1 receptor-mediated metal ion homeostasis in the murine brain promotes neurodegenerative disease
Violeta Chițu, Julia Alvarenga, Wenna Chen, David Reynolds, Yang Liu, Daqian Sun, Anders Sandell, Virginjia Danylaité-Karrenbauer, Per Uvdal, Iran A.N da Silva, Christophe Sandt, Oxana Klementieva, Ulf Johansson, Kavitha Subramanian Vignesh, Zbigniew K. Wszolek, Dennis W. Dickson, Jennifer T. Aguilian, Simone Sidoli, Deyou Zheng, E. Richard Stanley
Journal of Clinical Investigation, 2026
Dominant-inactivating mutations in the colony stimulating factor-1 receptor ( CSF1R ) cause CSF-1R–related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r +/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r +/– mice without pathological or behavioral alterations. Reduction of CSF-1R signaling caused metal ion accumulation in brain macrophages, with concomitant activation of cell death and stress response pathways in oligodendrocytes and neuronal subpopulations. Reduction of metallothionein 1 ( Mt1 ) and 3 ( Mt3 ) gene expression was a common feature in glial and neuronal cells of Csf1r +/– mice. Overexpression of Mt1 restored metal ion homeostasis, normalized ROS production in microglia, and prevented the development of behavioral deficits, while Mt3 deletion had disease-enhancing effects. These findings demonstrate CSF-1R regulation of metal ion homeostasis via metallothioneins in the brain. - Polystyrene nanoplastic exposure promotes amyloid misfolding and metabolic impairment at sublethal doses. A subcellular infrared imaging study
Iran Augusto Neves da Silva, Agnes Paulus, Valeriia Skoryk, Kar-Yan Su, Fátima Herranz-Trillo, Oxana Klementieva
Environmental Science Nano, 2026
Sub-diffraction O-PTIR imaging reveals that polystyrene nanoplastics penetrate cells and promote pathological amyloid-β misfolding at sublethal doses. - Mid-Infrared Photothermal Mesoscopy with Millimeter Field of View and Sub-micron Spatial Resolution
Rong Tang, Jiaze Yin, Bethany Weinberg, Haonan Lin, Jiahui Lu, David Gate, Oxana Klementieva, Ji-Xin Cheng
Progress in Biomedical Optics and Imaging Proceedings of SPIE, 2026 - A distinct lineage pathway drives parvalbumin chandelier cell fate in human interneuron reprogramming
Christina A. Stamouli, Alexander Degener, Efrain Cepeda-Prado, Andreas Bruzelius, Emil Andersson, Jessica Giacomoni, Aurélie Delphine Vorgeat, Srisaiyini Kidnapillai, Oxana Klementieva, Malin Parmar, Victor Olariu, Daniella Rylander Ottosson
Science Advances, 2026
Direct lineage reprogramming of glial cells to induced neurons has the potential for restoring brain circuits and function in neuronal disorders and states. We introduce three-dimensional (3D) human glia reprogramming into neurons with a GABAergic interneuron phenotype using stem cell–derived human glia. Single-nucleus RNA sequencing of the converted cells demonstrates distinct neuronal clusters within 2 weeks, including a parvalbumin (PV) cluster with high neuronal maturity and features of chandelier interneurons. A lineage trajectory analysis of the glia-to-neuron conversion reveals a distinct lineage pathway to PV chandelier fate, including various neuronal developmental stages and the establishment of synaptic machinery. This analysis reveals PV fate-important genes that are previously unknown to neural reprogramming with promising functional importance for future derivations. Our data demonstrate successful human glia conversion into interneurons with features of bona fide PV subtype and highlight the reprogramming trajectory with key transitional genes. This advancement holds promise for future human brain cell engineering and repair. - Strain-Distinct α-Synuclein and Tau Cross-Seeding Uncovered by Correlative Approach with Optical Photothermal Infrared Sub-Micron Imaging
Xiaoni Zhan, Wen Li, Eric Hatterer, Jean-Philippe Courade, Kristin Piché, Oxana Klementieva, Jia-Yi Li
Journal of the American Chemical Society, 2025
The co-occurrence of α-synuclein (αSyn) and Tau in synucleinopathies and tauopathies suggests a complex interplay between these proteins. Their cross-seeding enhances fibrillization, leading to the formation of diverse amyloid-specific structures enriched with β-sheets, which may influence their biological functions. However, existing tools cannot differentiate structural polymorphs directly in cells, as conventional microscopic approaches have limitations in providing structural insights into aggregates. As a result, a structurally relevant characterization of amyloids in their native cellular environment has not yet been achieved. In this study, we characterize the structural rearrangements of newly formed αSyn inclusions cross-seeded by different αSyn and Tau preformed fibrils (PFFs) directly in cells, using a correlative approach that combines submicron optical photothermal infrared (O-PTIR) microspectroscopy and confocal microscopy. We found that hybrid PFFs synthesized from αSyn, and two Tau isoforms (Tau3R and Tau4R) exhibit variations in αSyn and Tau composition. Specifically, structural polymorphs composed of αSyn and Tau3R exhibit the highest β-sheet content and most potent seeding potency, leading to enhanced phosphorylation within cellular inclusions. Importantly, we demonstrate that cellular inclusions inherit structural motifs from their donor seeds and exhibit distinct spatial and structural evolution. By providing subcellular-resolution structural imaging of amyloid proteins, our study uncovers divergent mechanisms of αSyn aggregation induced by αSyn/Tau PFFs in both mixed and hybrid formats. - Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons[Figure presented]
Emma Nyberg, Sabine C. Konings, Nils Lindblom, Bodil Israelsson, Oxana Klementieva, Isak Martinsson, Gunnar K. Gouras
Journal of Biological Chemistry, 2025
Apolipoprotein E4 (ApoE4), the major genetic risk factor for Alzheimer's disease (AD), is vital for understanding cellular processes involved in AD pathogenesis. Evidence implicates endosomes as a central player in AD, where endosomal enlargement in neurons is among the earliest changes in AD. This enlargement was reported to be enhanced in APOE4 carriers. Cells internalize ApoE into endosomes for lipid delivery, and previous studies indicate that ApoE4 influences endosomes. However, the effect of ApoE4 on endosome function seems different depending on cell type, and our understanding of how ApoE4 influences endosomes in mature neurons, the cell type degenerating in AD, remains limited. We aimed to increase understanding of the impact ApoE4 has on endosomal dynamics in primary neurons and whether external triggers, such as time-in-culture/aging, synaptic activity, and cholesterol, influence these endosomal changes. We show that without external triggers, mature primary neurons from ApoE knockout (KO), ApoE3, and ApoE4 mice show no major differences in endosomal appearance and function and adapt similarly to increased synaptic activity. However, with prolonged time in culture, neurons with ApoE4 show reduced degradative ability, along with a decreased number of active lysosomal compartments. Moreover, when supplying aged cultures with cholesterol, ApoE4 neurons have a predisposition to accumulate cholesterol in the endolysosomal system. Taken together, we show that ApoE4 impacts endolysosome function in primary neurons, but that changes emerge only after prolonged time in culture. A better understanding of how ApoE4 impacts neurons could provide important insights into ApoE4-directed therapy for AD. - Molecular architectures of glycosylated dendronized bottle brushes in action: Biocompatibility and anti-amyloidogenic activity of pseudo-glycodendrimers
Tom Kösterke, Radika Thakore, Silvia Moreno, Jan Skov Pedersen, Brigitte Voit, Oxana Klementieva, Dietmar Appelhans
Materials Today Bio, 2025
Glycopolymers are versatile materials for biomedical and healthcare applications, e.g., as carrier and polymeric therapeutics. Especially, the topology and surface composition of such materials play a key role in being promising materials in the anti-amyloidogenic interventions. Herein, 2 nd and 3 rd generation of pseudo-glycodendrimers ( PGDs ), based on hyperbranched polyester core with different sugar decorations, are synthesized, characterized, and used to investigate their anti-amyloidogenic properties toward Aβ (1-40) and (1-42), key players in Alzheimers´ disease. The findings reveal that PGDs have a dendronized bottle brush architecture, as determined by SAXS analysis. PGDs are capable of interfering with the aggregation process of Amyloid-β peptides due to the high degree of sugar functionalization on the outer surface and the specific molecular shape. Additionally, cell viability studies indicate that PGDs exhibit concentration-dependent biocompatibility. Importantly, it is demonstrated that PGDs can be multi-functionalized by various sugar molecules, dyes, and/or peptides in a final one-pot approach. These findings suggest that PGDs may offer new avenues for therapeutic research in neurodegenerative diseases. Finally, it should be noted that this kind of highly branched glycopolymers possesses a molecular shape of dendronized bottle brushes and not a globular perfectly branched structure like glycodendrimers, as originally postulated. • Improved synthesis of pseudo-glycodendrimers with higher degree of sugar functionalization • Sequential one-pot surface decoration for multifunctionalized pseudo-glycodendrimers • Pseudo-glycodendrimers attributed to dendronized bottle brush as shape • Minor use of biocompatible pseudo-glycodendrimers as anti-amyloidogenic agent in ThT assay • Minor pseudo-glycodendrimer versus major polyamine-based glycodendrimer use in ThT assay - Erratum: Correction: Apolipoprotein E intersects with amyloid-β within neurons (Life science alliance (2023) 6 8 PII: e202402875 DOI: 10.26508/lsa.202201887)
Sabine C Konings, Emma Nyberg, Isak Martinsson, Laura Torres-Garcia, Oxana Klementieva, Claudia Guimas Almeida, Gunnar K Gouras
Life Science Alliance, 2024
Apolipoprotein E4, the most important genetic risk factor for Alzheimer's disease, is shown to internalize into neurons and intersect with amyloid-β in endosomes-autophagosomes of neurites and modulate intraneuronal amyloid-β-42. - Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain
Ana M. Espinosa‐Oliva, Rocío Ruiz, Manuel Sarmiento Soto, Antonio Boza‐Serrano, Ana I. Rodriguez‐Perez, María A. Roca‐Ceballos, Juan García‐Revilla, Marti Santiago, Sébastien Serres, Vasiliki Economopoulus, Ana E. Carvajal, María D. Vázquez‐Carretero, Pablo García‐Miranda, Oxana Klementieva, María J. Oliva‐Martín, Tomas Deierborg, Eloy Rivas, Nicola R. Sibson, José L. Labandeira‐García, Alberto Machado, María J. Peral, Antonio J. Herrera, José L. Venero, Rocío M. de Pablos
Neuropathology and Applied Neurobiology, 2024
AimsAccording to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α‐synuclein (α‐syn) in the gastrointestinal tract and midbrain dopaminergic neurons.MethodsWe have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS‐based rat model of gut inflammation in terms of α‐syn pathology.ResultsOur data support the existence of pathogenic α‐syn in both the gut and the brain, thus reinforcing the potential role of the ENS as a contributing factor in PD aetiology. Additionally, we have analysed the effect of a DSS‐based rat model of gut inflammation to demonstrate (i) the appearance of P‐α‐syn inclusions in both Auerbach's and Meissner's plexuses (gut), (ii) an increase in α‐syn expression in the ventral mesencephalon (brain) and (iii) the degeneration of nigral dopaminergic neurons, which all are considered classical hallmarks in PD.ConclusionThese results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut‐brain axis in initiating α‐syn aggregation and transport to the substantia nigra, resulting in neurodegeneration. - Bioactive Suture with Added Innate Defense Functionality for the Reduction of Bacterial Infection and Inflammation
Manoj Puthia, Jitka Petrlova, Ganna Petruk, Marta Butrym, Firdaus Samsudin, Madelene Å Andersson, Ann‐Charlotte Strömdahl, Sebastian Wasserstrom, Erik Hartman, Sven Kjellström, Lucrezia Caselli, Oxana Klementieva, Peter J. Bond, Martin Malmsten, Deepak Bushan Raina, Artur Schmidtchen
Advanced Healthcare Materials, 2023 - Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
Yuriy Pomeshchik, Erika Velasquez, Jeovanis Gil, Oxana Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren-Thorsson, Gunnar K. Gouras, Melinda Rezeli, Laurent Roybon
Acta Neuropathologica Communications, 2023 - Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer's disease-transgenic mice
M.G. Garcia, A. Paulus, S. Vázquez-Reyes, O. Klementieva, G.K. Gouras, S. Bachiller, T. Deierborg
Brain Behavior and Immunity Health, 2023 - Apolipoprotein E intersects with amyloid-β within neurons
Sabine C Konings, Emma Nyberg, Isak Martinsson, Laura Torres-Garcia, Oxana Klementieva, Claudia Guimas Almeida, Gunnar K Gouras
Life Science Alliance, 2023 - Galectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease
Juan García-Revilla, Antonio Boza-Serrano, Yiyun Jin, Devkee M. Vadukul, Jesús Soldán-Hidalgo, Lluís Camprubí-Ferrer, Marta García-Cruzado, Isak Martinsson, Oxana Klementieva, Rocío Ruiz, Francesco A. Aprile, Tomas Deierborg, José Luis Venero
Acta Neuropathologica, 2023 - Erratum: Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies (Stem Cell Reports (2020) 15(1) (256–273), (S2213671120301922), (10.1016/j.stemcr.2020.06.001))
Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, György Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K. Gouras, Laurent Roybon
Stem Cell Reports, 2023 - Fluorescently Guided Optical Photothermal Infrared Microspectroscopy for Protein-Specific Bioimaging at Subcellular Level
Craig Prater, Yeran Bai, Sabine C. Konings, Isak Martinsson, Vinay S. Swaminathan, Pontus Nordenfelt, Gunnar Gouras, Ferenc Borondics, Oxana Klementieva
Journal of Medicinal Chemistry, 2023 - Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos
Nika Gvazava, Sabine C. Konings, Efrain Cepeda-Prado, Valeriia Skoryk, Chimezie H. Umeano, Jiao Dong, Iran A. N. Silva, Daniella Rylander Ottosson, Nicholas D. Leigh, Darcy Elizabeth Wagner, Oxana Klementieva
Journal of the American Chemical Society, 2023 - Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases
Miriam Solomon, Vito Foderà, Annette Eva Langkilde, Perry Elliott, Fabrizio Tagliavini, Trevor Forsyth, Oxana Klementieva, Vittorio Bellotti
Journal of Translational Medicine, 2022 - Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner
S. Bachiller, I. Hidalgo, M. G. Garcia, A. Boza-Serrano, A. Paulus, Q. Denis, C. Haikal, O. Manouchehrian, O. Klementieva, J. Y. Li, C. J. Pronk, G. K. Gouras, T. Deierborg
Journal of Neuroinflammation, 2022 - Correlative imaging to resolve molecular structures in individual cells: Substrate validation study for super-resolution infrared microspectroscopy
Agnes Paulus, Sahana Yogarasa, Mustafa Kansiz, Isak Martinsson, Gunnar K. Gouras, Tomas Deierborg, Anders Engdahl, Ferenc Borondics, Oxana Klementieva
Nanomedicine Nanotechnology Biology and Medicine, 2022 - Parkinson’s disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein–induced changes in maturation and immune reactive properties
Carla Azevedo, Gabriel Teku, Yuriy Pomeshchik, Juan F. Reyes, Margarita Chumarina, Kaspar Russ, Ekaterina Savchenko, Anna Hammarberg, Nuno Jorge Lamas, Anna Collin, Gunnar K. Gouras, Oxana Klementieva, Martin Hallbeck, Ricardo Taipa, Mauno Vihinen, Laurent Roybon
Proceedings of the National Academy of Sciences of the United States of America, 2022 - The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation
Nadja Gustavsson, Ekaterina Savchenko, Oxana Klementieva, Laurent Roybon
Acta Neuropathologica Communications, 2021 - Correlative optical photothermal infrared and X-ray fluorescence for chemical imaging of trace elements and relevant molecular structures directly in neurons
Nadja Gustavsson, Agnes Paulus, Isak Martinsson, Anders Engdahl, Kadda Medjoubi, Konstantin Klementiev, Andrea Somogyi, Tomas Deierborg, Ferenc Borondics, Gunnar K. Gouras, Oxana Klementieva
Light Science and Applications, 2021 - Erratum: Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies (Stem Cell Reports (2020) 15(1) (256–273), (S2213671120301922), (10.1016/j.stemcr.2020.06.001))
Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, György Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K. Gouras, Laurent Roybon
Stem Cell Reports, 2021 - Nano‐infrared imaging of primary neurons
Raul O. Freitas, Adrian Cernescu, Anders Engdahl, Agnes Paulus, João E. Levandoski, Isak Martinsson, Elke Hebisch, Christophe Sandt, Gunnar Keppler Gouras, Christelle N. Prinz, Tomas Deierborg, Ferenc Borondics, Oxana Klementieva
Cells, 2021 - Amyloid structural changes studied by infrared microspectroscopy in bigenic cellular models of alzheimer’s disease
Agnes Paulus, Anders Engdahl, Yiyi Yang, Antonio Boza-Serrano, Sara Bachiller, Laura Torres-Garcia, Alexander Svanbergsson, Megg G. Garcia, Gunnar K. Gouras, Jia-Yi Li, Tomas Deierborg, Oxana Klementieva
International Journal of Molecular Sciences, 2021 - Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies
Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, György Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K. Gouras, Laurent Roybon
Stem Cell Reports, 2020 - Super-Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons
Oxana Klementieva, Christophe Sandt, Isak Martinsson, Mustafa Kansiz, Gunnar K. Gouras, Ferenc Borondics
Advanced Science, 2020 - Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection
Ester Aso, Isak Martinsson, Dietmar Appelhans, Christiane Effenberg, Nuria Benseny-Cases, Josep Cladera, Gunnar Gouras, Isidre Ferrer, Oxana Klementieva
Nanomedicine Nanotechnology Biology and Medicine, 2019 - Generation of an induced pluripotent stem cell line (CSC-46) from a patient with Parkinson's disease carrying a novel p.R301C mutation in the GBA gene
Nadja Gustavsson, Ana Marote, Yuriy Pomeshchik, Kaspar Russ, Carla Azevedo, Margarita Chumarina, Stefano Goldwurm, Anna Collin, Luisa Pinto, António J. Salgado, Oxana Klementieva, Laurent Roybon, Ekaterina Savchenko
Stem Cell Research, 2019 - S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer’s Disease
Chao Wang, Igor A. Iashchishyn, Jonathan Pansieri, Sofie Nyström, Oxana Klementieva, John Kara, Istvan Horvath, Roman Moskalenko, Reza Rofougaran, Gunnar Gouras, Gabor G. Kovacs, S. K. Shankar, Ludmilla A. Morozova-Roche
Scientific Reports, 2018 - Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice
O. Klementieva, J. Mathurin, A. Engdahl, R. Freitas, K. Willen, P. Uvdal, L.M. Miller, G. Gouras
International Conference on Infrared Millimeter and Terahertz Waves Irmmw Thz, 2018 - Prion-like seeding and nucleation of intracellular amyloid-β
Tomas T. Olsson, Oxana Klementieva, Gunnar K. Gouras
Neurobiology of Disease, 2018 - 3D membrane segmentation and quantification of intact thick cells using cryo soft X-ray transmission microscopy: A pilot study
Rubén Cárdenes, Chong Zhang, Oxana Klementieva, Stephan Werner, Peter Guttmann, Christoph Pratsch, Josep Cladera, Bart H. Bijnens
Plos One, 2017 - Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP
O. Klementieva, K. Willén, I. Martinsson, B. Israelsson, A. Engdahl, J. Cladera, P. Uvdal, G. K. Gouras
Nature Communications, 2017 - Microspectroscopy (μFTIR) reveals co-localization of lipid oxidation and amyloid plaques in human Alzheimer disease brains
Núria Benseny-Cases, Oxana Klementieva, Marine Cotte, Isidre Ferrer, Josep Cladera
Analytical Chemistry, 2014 - Effect of poly(propylene imine) glycodendrimers on β-amyloid aggregation in vitro and in APP/PS1 transgenic mice, as a model of brain amyloid deposition and alzheimer's disease
O. Klementieva, E. Aso, D. Filippini, N. Benseny-Cases, M. Carmona, S. Juvés, D. Appelhans, J. Cladera, I. Ferrer
Biomacromolecules, 2013 - Granular non-fibrillar aggregates and toxicity in Alzheimer's disease
Nuria Benseny-Cases, Oxana Klementieva, Jan Maly, Josep Cladera
Current Alzheimer Research, 2012 - In vitro oligomerization and fibrillogenesis of Amyloid-beta peptides
Núria Benseny-Cases, Oksana Klementieva, Josep Cladera
Subcellular Biochemistry, 2012 - Phosphorus dendrimers affect Alzheimer's (Aβ 1-28) peptide and MAP-Tau protein aggregation
Tomasz Wasiak, Maksim Ionov, Krzysztof Nieznanski, Hanna Nieznanska, Oxana Klementieva, Maritxell Granell, Josep Cladera, Jean-Pierre Majoral, Anne Marie Caminade, Barbara Klajnert
Molecular Pharmaceutics, 2012 - Dendrimers antiamyloidogenic potential in neurodegenerative diseases
Núria Benseny-Cases, Oxana Klementieva, Josep Cladera
New Journal of Chemistry, 2012 - Dense shell glycodendrimers as potential nontoxic anti-amyloidogenic agents in Alzheimer's disease. Amyloid-dendrimer aggregates morphology and cell toxicity
Oxana Klementieva, Núria Benseny-Cases, Alejandro Gella, Dietmar Appelhans, Brigitte Voit, Josep Cladera
Biomacromolecules, 2011
