Kirolos Eskandar

Scopus Publications

The role of artificial intelligence in orthopedic surgery: Current applications and future perspectives—A systematic review of the literature
K. Eskandar
Revista Espanola De Cirugia Ortopedica Y Traumatologia, 2026
Artificial intelligence and multi-omics integration in liquid biopsy for genitourinary cancers: a systematic scoping review
Kirolos Eskandar
International Urology and Nephrology, 2026
The Memory-Masturbation Link: Analyzing Psychological Impacts and Myths
Kirolos Eskandar
Sexuality and Culture, 2026
The link between masturbation and memory has been widely debated, with conflicting claims ranging from cognitive decline to potential mental clarity benefits. Historical and cultural stigmas have further contributed to misinformation, shaping societal attitudes without sufficient scientific backing. This review aims to critically analyze the neurobiological, psychological, and cognitive effects of masturbation, distinguishing scientific evidence from myths. A systematic literature review approach was adopted, sourcing peer-reviewed studies from databases such as PubMed, Google Scholar, PsycINFO, and Scopus. Research spanning neurobiological, psychological, and cognitive domains was analyzed, focusing on neurotransmitter activity, neuroplasticity, attention, and executive function. Studies examining societal beliefs and the role of pornography were also included to provide a holistic perspective. Findings suggest that masturbation influences neurochemical processes, including fluctuations in dopamine, serotonin, and oxytocin. These changes do not conclusively impair memory but may enhance mood regulation and stress relief, indirectly supporting cognitive function. While moderate masturbation does not negatively affect memory, compulsive behaviors, particularly when associated with excessive pornography consumption, have been linked to attentional deficits and psychological distress. There is no strong scientific basis for the belief that masturbation directly harms memory. Instead, its effects are context-dependent, influenced by individual psychological factors, cultural narratives, and behavioral patterns. Future research should further explore the long-term cognitive impacts of sexual activity, while public discourse should focus on dispelling myths and promoting a balanced, evidence-based understanding of sexual health and cognitive well-being.
Implantable bladder sensors for real-time urodynamics: A systematic review of preclinical and clinical evidence in neuro-urology
Kirolos Eskandar
Current Urology, 2026
Background: Catheter-based urodynamic studies remain the standard for diagnosing lower urinary tract dysfunction, but are limited by discomfort, infection risk, and restricted monitoring duration. Emerging implantable bladder sensors offer the potential for real-time wireless pressure monitoring without the need for catheters, with promising applications in neurology. This study was aimed to systematically review and compare the performance, safety, and translational readiness of intravesical and submucosal implantable bladder sensors used for real-time urodynamic assessments in preclinical and clinical studies. Materials and methods: A systematic literature search was conducted in PubMed, Scopus, and IEEE Xplore from their inception to July 10, 2025, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies that evaluated wireless implantable bladder pressure sensors in animal or human models were included. Data on the pressure fidelity, biocompatibility, implantation site, and signal stability were extracted and compared. Results: Four studies met the inclusion criteria: 3 preclinical studies (rabbit or pig) and 1 human feasibility trial. Intravesical sensors showed superior pressure fidelity (correlation coefficients up to r = 0.885), minimal error (±1 cm H 2 O), and favorable safety with no adverse effects. In humans, the UroMonitor device demonstrated an event-detection accuracy of 98% and was well tolerated. Submucosal devices achieved high event-specific correlations (r = 0.75–0.94) but were limited by erosion and signal degradation. Heterogeneity in sensor design, implantation duration, and biocompatibility has limited direct comparisons. Conclusions: Intravesical implantable sensors demonstrated higher accuracy, safety, and translational readiness than submucosal alternatives. The success of the UroMonitor in human feasibility studies underscores its potential for catheter-free ambulatory bladder pressure monitoring. Future studies should focus on long-term implantation, artificial intelligence integration, and comparative trials using conventional urodynamics.
The role of uropathogenic Escherichia coli biofilms in antibiotic-resistant urinary tract infections: Nanoparticle-based, phage therapy, and quorum-sensing inhibitor approaches
Kirolos Eskandar
Current Urology, 2026
Background: Urinary tract infections (UTIs) caused by uropathogenic E. coli (UPEC) pose a global health challenge, largely due to UPEC biofilms that drive persistent infections and antibiotic resistance. Materials and methods: To explore the role of UPEC biofilms in antibiotic-resistant UTIs and summarize emerging therapeutic strategies, this study conducted a systematic review adhering to PRISMA guidelines and registered in PROSPERO (CRD420251040212). A structured search of PubMed, Google Scholar, Scopus, and Web of Science identified English-language studies published up to 2024, with 57 eligible studies selected after three-stage screening and analyzed via thematic synthesis. Results: This study explored UPEC biofilms enhance resistance through extracellular matrix barriers, persister cell formation, efflux pump upregulation, and horizontal gene transfer; emerging therapies including bacteriophage therapy, quorum-sensing inhibitors, and nanoparticle-based drug delivery effectively target biofilms by penetration, signaling disruption, and improved drug efficacy. Additional approaches such as antibiofilm peptides, probiotics, and immunotherapy also demonstrate potential. Conclusions: The UPEC biofilms are key to chronic UTIs, and novel targeted therapies offer promising solutions, but clinical validation, regulatory hurdles, and combination therapy optimization are critical for translation to clinical practice.
Real-world deployment of machine learning models for opioid overdose and opioid use disorder: a systematic review of clinical and operational lessons for addiction medicine
Kirolos Eskandar
Journal of Addictive Diseases, 2026
Efficacy of Sodium–Glucose Cotransporter 2 Inhibitors in Chronic Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Kirolos Eskandar
Ukrainskyi Zhurnal Sertsevo Sudynnoi Khirurhii, 2025
Background. Sodium–glucose cotransporter 2 (SGLT2) inhibitors are now a foundational therapy for heart failure (HF), yet uncertainties remain regarding their impact on mortality, recurrent events, patient-reported outcomes, and biomarkers.Aim. To evaluate the efficacy and safety of sodium–glucose cotransporter 2 (SGLT2) inhibitors in patients with chronic heart failure across the spectrum of ejection fraction, based on evidence from randomized controlled trials.Materials and Methods. We conducted a systematic review and meta-analysis in accordance with PRISMA 2020 (PROSPERO: CRD420251138644). PubMed, Embase, Cochrane CENTRAL, and ClinicalTrials.gov were searched through 25 June 2025. Eligible studies were randomized controlled trials (RCTs) of SGLT2 inhibitors versus placebo in adults with chronic HF. The primary endpoint was time to first cardiovascular (CV) death or HF hospitalization. Secondary outcomes included all-cause mortality, recurrent hospitalizations, quality of life, natriuretic peptides, and safety. Hazard ratios (HRs) were pooled using Hartung–Knapp random-effects models where definitions were consistent; other outcomes were narratively synthesized. Risk of bias was assessed with RoB 2, and the certainty of evidence with GRADE.Results. Five RCTs (n = 16,222) were included: DAPA-HF, EMPEROR-Reduced, DELIVER, SOLOIST-WHF (providing recurrent-event analyses), and DEFINE-HF (mechanistic, biomarker-focused). SGLT2 inhibitors reduced the risk of CV death or HF hospitalization (pooled HR 0.79, 95% CI 0.74–0.83; I² = 0%). The reduction in hospitalization was consistent across trials (HRs ≈ 0.69–0.75), while all-cause mortality showed a modest but significant benefit (HR 0.90, 95% CI 0.83–0.98). Trials consistently demonstrated improvements in Kansas City Cardiomyopathy Questionnaire (KCCQ) scores and natriuretic peptide response rates. Safety findings were consistent with the established SGLT2 inhibitor profile, with no signals of serious adverse events.Conclusions. SGLT2 inhibitors confer robust reductions in HF hospitalizations and provide supportive benefits on mortality, quality of life, and biomarkers across EF phenotypes, reinforcing their role as a cornerstone therapy in chronic HF.
FocalONE high-intensity focused ultrasound for localized prostate cancer: A systematic review of oncologic outcomes, functional preservation, and technological evolution
K. Eskandar
Actas Urologicas Espanolas, 2025
Single-port robotic-assisted radical prostatectomy: evaluating the Da Vinci SP system in minimally invasive urologic oncology
Kirolos Eskandar
World Journal of Urology, 2025
Artificial intelligence in hepatology: A comprehensive scoping review of clinical applications, challenges, and future directions
Kirolos Eskandar
Iliver, 2025
The gut–brain axis in depression, anxiety, and schizophrenia: a scoping review of mechanisms, biomarkers, and therapeutic implications
Kirolos Eskandar
Middle East Current Psychiatry, 2025
Artificial Intelligence in CT Imaging: A Systematic Review of Diagnostic Accuracy, Clinical Decision–Support Impact, and Integration Pathways
Kirolos Eskandar
Iradiology, 2025
Stem cells, PRP, and bioprinting — Advancements in regenerative medicine for orthopedic disorders
Kirolos Eskandar
Revista De Osteoporosis Y Metabolismo Mineral, 2025
Green biotech: innovations driving a sustainable future
Eqa, 2025
Exosomes in Wound Healing: Biological Roles and Mechanistic Insights
K. Eskandar
Innovative Medicine of Kuban, 2025
3D-bioprinted urethral grafts: Revolutionizing urethral stricture treatment
Kirolos Eskandar
Arab Journal of Urology, 2025
Exploring the potential of bi-specific antibodies in cancer immunotherapy
Kirolos Eskandar
Khirurgiya I Onkologiya, 2025
Artificial intelligence in urology: Revolutionizing diagnostics and treatment planning
Kirolos Eskandar
Arab Journal of Urology, 2025
Artificial intelligence in aesthetic and reconstructive surgery: Clinical applications, ethical challenges, and future trends
K. Eskandar
Sibirskij Nauchnyj Medicinskij Zhurnal, 2025
Genetic contributions to sexual relationship dynamics: A narrative review
К. Eskandar
Sibirskij Nauchnyj Medicinskij Zhurnal, 2025
The digital trap: unraveling the neuropsychological impact of technology addiction
Kirolos Eskandar
Neuropsychological Trends, 2025
Nanotechnology and Drug Delivery Systems in Wound Healing and Scar Reduction
K. Eskandar
Innovative Medicine of Kuban, 2025
Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers
Kirolos Eskandar
Uroprecision, 2025
Exosome-Based Therapies for Scar-Free Skin Regeneration: Clinical Applications and Emerging Trends
E. Kirolos
Innovative Medicine of Kuban, 2025
Frontiers in Dermatological Innovation: a Systematic Review of Emerging Therapies, Technologies, and Clinical Practices
Kirolos Eskandar
Przeglad Dermatologiczny, 2025
Crossroads of Neurology and Virology: The Neurological Manifestations of COVID-19
Kirolos Eskandar
Ukrainian Neurosurgical Journal, 2024
Artificial intelligence in nephrology: revolutionizing diagnosis, treatment, and patient care
Kirolos Eskandar
Kidneys, 2024
The evolving role of surgery in multimodal cancer treatment: a comprehensive review
Kirolos Eskandar
Khirurgiya I Onkologiya, 2024
Emerging trends in oncology: a comprehensive literature review
Kirolos Eskandar
Khirurgiya I Onkologiya, 2024

RECENT SCHOLAR PUBLICATIONS

Assessing ChatGPT Accuracy Across Versions for Patient and Guideline Queries in Sacral Neuromodulation
K Eskandar
Société Internationale d’Urologie Journal 7 (1), 11 , 2026
2026
Citations: 1
Artificial intelligence and synthetic biology: biosecurity risks, dual-use concerns, and governance pathways
K Eskandar
AI and Ethics 6 (1), 66 , 2026
2026
The Memory-Masturbation Link: Analyzing Psychological Impacts and Myths
K Eskandar
Sexuality & Culture 30 (1), 549-571 , 2026
2026
Artificial intelligence and rule-based decision support for medication optimization in older adults: a systematic scoping review of polypharmacy management tools and ethical …
K Eskandar
Geriatric Pharmacology 3 (1), 2596797 , 2026
2026
Real-world deployment of machine learning models for opioid overdose and opioid use disorder: a systematic review of clinical and operational lessons for addiction medicine
K Eskandar
Journal of Addictive Diseases, 1-19 , 2025
2025
Citations: 1
Efficacy of Sodium–Glucose Cotransporter 2 Inhibitors in Chronic Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
K Eskandar
Ukrainian Journal of Cardiovascular Surgery 33 (4), 94-105 , 2025
2025
Artificial intelligence and multi-omics integration in liquid biopsy for genitourinary cancers: a systematic scoping review
K Eskandar
International Urology and Nephrology, 1-22 , 2025
2025
Citations: 5
The gut–brain axis in depression, anxiety, and schizophrenia: a scoping review of mechanisms, biomarkers, and therapeutic implications
K Eskandar
Middle East Current Psychiatry 32 (1), 1-21 , 2025
2025
Citations: 8
Single-port robotic-assisted radical prostatectomy: evaluating the Da Vinci SP system in minimally invasive urologic oncology
K Eskandar
World Journal of Urology 43 (1), 711 , 2025
2025
Citations: 1
Artificial Intelligence in CT Imaging: A Systematic Review of Diagnostic Accuracy, Clinical Decision–Support Impact, and Integration Pathways
K Eskandar
iRADIOLOGY 3 (6), 434-445 , 2025
2025
Citations: 2
Экзосомальная терапия для безрубцового восстановления кожи: клиническое применение и новые тенденции
Э Киролос
Инновационная медицина Кубани 10 (4), 121-128 , 2025
2025
Artificial intelligence in hepatology: A comprehensive scoping review of clinical applications, challenges, and future directions
K Eskandar
Iliver, 100205 , 2025
2025
Citations: 4
VALIDATED ARTIFICIAL INTELLIGENCE APPLICATIONS IN PANDEMIC PREPAREDNESS: A FOCUSED SCOPING REVIEW OF PEER-REVIEWED, EXPLICITLY VALIDATED STUDIES
K Eskandar
Russian Journal of Infection and Immunity , 2025
2025
Neuroinflammation and psychiatry: bridging the gap between the immune system and mental health
K Eskandar
Neuropsychological Trends, 21-39 , 2025
2025
The role of artificial intelligence in orthopedic surgery: Current applications and future perspectives—A systematic review of the literature
K Eskandar
Revista Española de Cirugía Ortopédica y Traumatología , 2025
2025
Citations: 4
FocalONE High-Intensity Focused Ultrasound for Localized Prostate Cancer: A Systematic Review of Oncologic Outcomes, Functional Preservation, and Technological Evolution
K Eskandar
Actas Urológicas Españolas (English Edition), 501869 , 2025
2025
Citations: 2
The role of uropathogenic Escherichia coli biofilms in antibiotic-resistant urinary tract infections: Nanoparticle-based, phage therapy, and quorum-sensing inhibitor approaches
K Eskandar
Current Urology, 10.1097 , 2025
2025
Frontiers in Dermatological Innovation: a Systematic Review of Emerging Therapies, Technologies, and Clinical Practices
K Eskandar
Dermatology Review/Przegląd Dermatologiczny 112 (3), 161-175 , 2025
2025
3D-bioprinted urethral grafts: revolutionizing urethral stricture treatment
K Eskandar
Arab Journal of Urology 23 (4), 330-340 , 2025
2025
Citations: 2
Artificial intelligence in urology: Revolutionizing diagnostics and treatment planning
K Eskandar
Arab journal of urology 23 (4), 341-347 , 2025
2025
Citations: 7

MOST CITED SCHOLAR PUBLICATIONS

Revolutionizing biotechnology and bioengineering: unleashing the power of innovation
K Eskandar
J Appl Biotechnol Bioeng 10 (3), 81-88 , 2023
2023
Citations: 46
Artificial intelligence in healthcare: explore the applications of AI in various medical domains, such as medical imaging, diagnosis, drug discovery, and patient care
K Eskandar
Series Med Sci 4 (1), 37-53 , 2023
2023
Citations: 28
Artificial intelligence in nephrology: revolutionizing diagnosis, treatment, and patient care
K Eskandar
KIDNEYS 13 (3), 213-219 , 2024
2024
Citations: 13
The gut–brain axis in depression, anxiety, and schizophrenia: a scoping review of mechanisms, biomarkers, and therapeutic implications
K Eskandar
Middle East Current Psychiatry 32 (1), 1-21 , 2025
2025
Citations: 8
Artificial intelligence in psychiatric diagnosis: challenges and opportunities in the era of machine learning
K Eskandar
Debates em Psiquiatria 14, 1-16 , 2024
2024
Citations: 8
The impact of virtual reality exposure therapy in the treatment of PTSD and anxiety disorders
K Eskandar
Debates em Psiquiatria 14, 1-21 , 2024
2024
Citations: 8
Artificial intelligence in urology: Revolutionizing diagnostics and treatment planning
K Eskandar
Arab journal of urology 23 (4), 341-347 , 2025
2025
Citations: 7
3D bioprinting for facial reconstruction: Advances and challenges
K Eskandar
Regenesis Repair Rehabilitation 1 (3), 16-23 , 2025
2025
Citations: 6
Smart orthopedic implants: the future of personalized joint replacement and monitoring
K Eskandar
Гений ортопедии 31 (3), 388-398 , 2025
2025
Citations: 6
Artificial intelligence and multi-omics integration in liquid biopsy for genitourinary cancers: a systematic scoping review
K Eskandar
International Urology and Nephrology, 1-22 , 2025
2025
Citations: 5
The digital trap: unraveling the neuropsychological impact of technology addiction
K Eskandar
Neuropsychological Trends 37, 7-19 , 2025
2025
Citations: 5
Nanotechnology in cancer treatment: innovative approaches to overcoming drug resistance in tumors
K Eskandar
Indonesian Journal of Cancer Chemoprevention 15 (2), 162-174 , 2024
2024
Citations: 5
Artificial intelligence in hepatology: A comprehensive scoping review of clinical applications, challenges, and future directions
K Eskandar
Iliver, 100205 , 2025
2025
Citations: 4
The role of artificial intelligence in orthopedic surgery: Current applications and future perspectives—A systematic review of the literature
K Eskandar
Revista Española de Cirugía Ortopédica y Traumatología , 2025
2025
Citations: 4
Regenerative medicine in plastic surgery: the role of stem cells and bioprinting
K Eskandar
Regenesis Repair Rehabilitation 1 (2), 51-59 , 2025
2025
Citations: 4
Advancements in gynecology: A comprehensive review of emerging research and innovations
K Eskandar
Journal of Medical and Clinical Nursing Studies, 1-12 , 2024
2024
Citations: 4
Therapeutic breakthroughs in oncology: Enhancing treatment and management
K Eskandar
Canadian Oncology Nursing Journal 35 (4), 590 , 2025
2025
Citations: 3
Bioprinting in Organ Transplantation: From Experimental Models to Clinical Prospects
K Eskandar
Brazilian Journal of Transplantation 28, e1825 , 2025
2025
Citations: 3
The Influence of Sex Hormones on Cardiovascular Health: Current Perspectives and Future Directions
K Eskandar
Revista Peruana de Ciencias de la Salud 6 (2), 162-170 , 2024
2024
Citations: 3
Artificial Intelligence in CT Imaging: A Systematic Review of Diagnostic Accuracy, Clinical Decision–Support Impact, and Integration Pathways
K Eskandar
iRADIOLOGY 3 (6), 434-445 , 2025
2025
Citations: 2

Kirolos Eskandar

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS