Restoring Balance: Probiotic Modulation of Microbiota, Metabolism, and Inflammation in SSRI-Induced Dysbiosis Using the SHIME® Model Marina Toscano de Oliveira, Fellipe Lopes de Oliveira, Mateus Kawata Salgaço, Victoria Mesa, Adilson Sartoratto, Kalil Duailibi, Breno Vilas Boas Raimundo, Williams Santos Ramos, Katia Sivieri Pharmaceuticals, 2025 Background/Objectives: Selective serotonin reuptake inhibitors (SSRIs), widely prescribed for anxiety disorders, may negatively impact the gut microbiota, contributing to dysbiosis. Considering the gut–brain axis’s importance in mental health, probiotics could represent an effective adjunctive strategy. This study evaluated the effects of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 on microbiota composition, metabolic activity, and immune markers in fecal samples from patients with anxiety on SSRIs, using the SHIME® (Simulator of the Human Intestinal Microbial Ecosystem) model. Methods: The fecal microbiotas of four patients using sertraline or escitalopram were inoculated in SHIME® reactors simulating the ascending colon. After stabilization, a 14-day probiotic intervention was performed. Microbial composition was assessed by 16S rRNA sequencing. Short-chain fatty acids (SCFAs), ammonia, and GABA were measured, along with the prebiotic index (PI). Intestinal barrier integrity was evaluated via transepithelial electrical resistance (TEER), and cytokine levels (IL-6, IL-8, IL-10, TNF-α) were analyzed using a Caco-2/THP-1 co-culture system. The statistical design employed in this study for the analysis of prebiotic index, metabolites, intestinal barrier integrity and cytokines levels was a repeated measures ANOVA, complemented by post hoc Tukey’s tests to assess differences across treatment groups. For the 16S rRNA sequencing data, alpha diversity was assessed using multiple metrics, including the Shannon, Simpson, and Fisher indices to evaluate species diversity, and the Chao1 and ACE indices to estimate species richness. Beta diversity, which measures microbiota similarity across groups, was analyzed using weighted and unweighted UniFrac distances. To assess significant differences in beta diversity between groups, a permutational multivariate analysis of variance (PERMANOVA) was performed using the Adonis test. Results: Probiotic supplementation increased Bifidobacterium and Lactobacillus, and decreased Klebsiella and Bacteroides. Beta diversity was significantly altered, while alpha diversity remained unchanged. SCFA levels increased after 7 days. Ammonia levels dropped, and PI values rose. TEER values indicated enhanced barrier integrity. IL-8 and TNF-α decreased, while IL-6 increased. GABA levels remained unchanged. Conclusions: The probiotic combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 modulated gut microbiota composition, metabolic activity, and inflammatory responses in samples from individuals with anxiety on SSRIs, supporting its potential as an adjunctive strategy to mitigate antidepressant-associated dysbiosis. However, limitations—including the small pooled-donor sample, the absence of a healthy control group, and a lack of significant GABA modulation—should be considered when interpreting the findings. Although the SHIME® model is considered a gold standard for microbiota studies, further clinical trials are necessary to confirm these promising results.
Exploring the Frontiers of Psychedelics: A New Chromatographic Method for Detection and Quantification of Psilocybin and Psilocin in Psilocybe cubensis Mushrooms Taynah Pereira Galdino, Lucas C. Oliveira, Mateus A. Luz, Raquel Costa Barbosa, Maria C. M. Torres, Katia Sivieri, Paula A. Fernandes, Márcio L. Santos, Antonio G. B. Lima, Suédina M. L. Silva, Marcus V. L. Fook ACS Omega, 2025 Innovative therapies, such as psilocybin-assisted psychotherapies, hold great promises for treating anxiety, depression, and various other mental health disorders, addressing some of the challenges faced by conventional psychiatric medicine. This study focuses on developing and validating an HPLC-DAD methodology for detecting psilocybin and psilocin in extracts from psychedelic mushrooms intended for medicinal use. The methodology to has been validated following the guidelines of RDC No. 166/2017 from the Brazilian National Health Surveillance Agency (ANVISA). Utilizing a PerkinElmer C18 column (150.0 mm length × 4.6 mm internal diameter × 5 μm particle size), the gradient method employed ultrapure Milli-Q water (mobile phase A) and acetonitrile (mobile phase B), both acidified to 0.3% with formic acid (starting at a ratio of 95:5 v/v), with a flow rate of 0.8 mL/min over 18 min and an injection volume of 15 μL. The column temperature was maintained at 30 °C, and the analysis was conducted at a wavelength of 266 nm. The limit of detection (LOD) and limit od quantification (LOQ) values for psilocybin were 1.58 and 4.78 mg/L, respectively, while for psilocin, they were 1.70 and 5.17 mg/L. The method's accuracy showed recovery intervals for psilocybin ranging from 80 to 120% and for psilocin from 98 to 116%. Accurately determining the content of psilocybin (2.57%) and psilocin (0.16%) is essential for their application as pharmaceutical compounds. This methodological rigor ensures that these substances can be reliably used in therapeutic contexts, underscoring the importance of precise quantification in developing safe and effective medical treatments.
Effects on Physicochemical and Microbiological Properties of Coconut Water Packaged in Silver-Based Materials João Otávio Donizette Malafatti, Sabrina da Costa Brito, Vinicius Alex Cano Pereira, Ítalo Calisto, Saad Barbar Netto, Carlos Eduardo Formigoni, Murilo Daniel de Mello Innocentini, Milene Corso Mitsuyuki, Kátia Sivieri, Marcos David Ferreira Packaging Technology and Science, 2025 Coconut water is a fresh and popular drink that is attractive to consumers worldwide. Packaging development is essential to improve product quality, protect against microorganism contamination and preserve their physical‐chemistry properties. Silver nanoparticles (AgNPs) are excellent actives applied in studies of food packaging, exhibiting great antimicrobial activity and reinforcement properties in polymeric matrices. The current work goals are to evaluate AgNPs supported on carriers, silica (SiO2) and hydroxyapatite (Hap) in the linear low‐density polyethylene (LLDPE) polymer obtained nanocomposite materials (LLDPE/AgNPs) to coconut water packaging. Thus, the present assay ascertained if adding these active agents in a commercial material (LLDPE) may improve coconut water's physicochemical and microbiological characteristics. The processing obtained the packaging composites at two concentrations (0.4% and 0.6%) by extrusion methodology. The pasteurized coconut water was packaged and monitored during 35 days of storage at temperatures above the recommended (7°C). The physicochemical analyses of coconut water verified the maintenance of pH, titratable acidity, soluble solids content, colour, turbidity, phenolic compounds, antioxidant activities, reducing and nonreducing sugars and minerals. Microbiological analyses were performed to detect the growth of psychrotrophic, moulds and yeasts, enterobacteria and Salmonella spp. The results showed that the AgNPs supported in both particles did not affect coconut water's physical and chemical characteristics compared to the LLDPE control. Concerning microbial growth, adding particles reduced the product's microbial load. Thus, the LLDPE/AgNPs packages obtained in this work demonstrated a potential application as commercial material to coconut water that can preserve the intrinsic physicochemical and improve the microbiological quality.
Bugs got milk? Exploring the potential of lactose as a prebiotic ingredient for the human gut microbiota of lactose-tolerant individuals Rita de Cassia Pessotti, Mathilde Guerville, Laira Lorraine Agostinho, Cristina Stewart Bittencourt Bogsan, Mateus Kawata Salgaço, Amandine Ligneul, Miller Nunes de Freitas, Cristiano Ruch Werneck Guimarães, Katia Sivieri Nutrition Research, 2025 • Short and long-duration in vitro colonic fermentation revealed the prebiotic effect of lactose. • Beta-diversity analysis indicated changes in microbial composition. • Relative abundance of Lactobacillus, Akkermansia , and Faecalibacterium increased. • Relative abundance of the usually harmful genus Clostridium decreased. • Short-chain fatty acids metabolism was modulated. Milk consumption is important to help meet daily nutrient requirements. However, lactose - present in dairy products - has been associated with digestive discomfort in individuals who are lactose intolerant or have inadequate lactase activity. Yet, a new perspective on this dietary component has emerged: its potential as a prebiotic for the lactose-tolerant population. We hypothesized that ingestion of lactose may improve both the microbial community structure and metabolism of the gut microbiota from healthy adults. First, we assessed the acute impact of lactose ingestion on the gut microbiota of adults using a short-duration in vitro batch colonic model. Subsequently, we employed a long-duration in vitro dynamic multi-vessel colonic model to evaluate the effects of chronic ingestion of lactose on the gut microbiota. In both cases, a mixture of lactose/galactose/glucose was administered in a defined proportion to mimic lactose metabolism and galactose/glucose absorption in the small intestine in lactose tolerant adults. The main hypothesis was confirmed, as a modulatory prebiotic effect was revealed on the microbial community structure and metabolism of the microbiota upon treatments simulating the ingestion of three doses of lactose, equivalent to the consumption of half a glass, one glass, and two glasses of cow's milk. The long-duration model confirmed this potential, leading to an increase in the relative abundance of the beneficial genera Lactobacillus, Akkermansia , and Faecalibacterium , while the usually detrimental genus Clostridium decreased. Additionally, an increase in health-promoting microbial metabolites such as acetate, propionate, and lactate was observed. Therefore, lactose ingestion could positively modulate the gut microbiota in healthy lactose-tolerant adults, thereby promoting gut health and shedding light on the dietary benefits of consuming milk. The impact of acute and chronic ingestion of lactose on the gut microbiota of adults was assessed using a short-duration in vitro batch colonic model and long-duration in vitro dynamic multi-vessel colonic model. A modulatory prebiotic effect was revealed on the structure and metabolism of the microbiota upon all treatments compared to control. Therefore, the lactose ingestion in healthy lactose tolerant adults may promote gut health, shedding light on the dietary benefits of consuming milk.
Extraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications Taynah P. Galdino, Lucas C. Oliveira, Mateus A. Luz, Raquel A. Jesus, Eunice P. N. Lima, Maria C. M. Torres, Katia Sivieri, Victor I. Afonso, João M. P. Q. Delgado, Antonio G. B. Lima, Suédina M. L. Silva, Marcus V. L. Fook Pharmaceuticals, 2025 The growing body of evidence supporting the therapeutic efficacy of psychoactive substances, like psilocybin, has driven significant interest in recent decades due to their low toxicity and potential applications in treating various mental health disorders. However, producing pharmaceutical-grade psilocybin remains challenging, with three primary approaches: chemical synthesis, biosynthesis, and extraction from Psilocybe mushroom fruiting bodies. This systematic review evaluates the extraction and quantification methods for psilocybin and psilocin, aiming to contribute to the development of standardized protocols that ensure compound quality and purity. A total of 25 relevant studies were selected from an initial pool of 9152 publications indexed in platforms such as Scopus, ScienceDirect, Web of Science, and PubMed. The findings indicate that both the extraction method and the choice of mushroom species significantly influence compound yields. Ultrasonic bath extraction was identified as the most efficient technique, particularly for species including Psilocybe cyanescens and Psilocybe cubensis. High-performance liquid chromatography (HPLC) was the most-used method for identifying and quantifying these compounds. Furthermore, polar solvents were critical for effective solubilization, with parameters such as temperature, solvent-to-material ratio, and extraction time playing key roles in optimizing yields. This review serves as a key scientific reference for advancing research, enhancing analytical precision, and ensuring reproducibility through the standardization of extraction and quantification protocols.
Unconventional food plants from Brazil Mateus Kawata Salgaço, Vanderson Gabriel Souza Torres, David de Paulo Farias, Flavio Alexandre Carvalho, Laira Lorraine Agostinho, André Gonzaga dos Santos, Katia Sivieri Science and Culture of Latin American Foods Harnessing Ingredients for Health, 2025
Postbiotics — when simplification fails to clarify José Eleazar Aguilar-Toalá, Stefania Arioli, Pradip Behare, Clara Belzer, Roberto Berni Canani, Jean-Marc Chatel, Enza D’Auria, Mônica Queiroz de Freitas, Eran Elinav, Erick Almeida Esmerino, Hugo S. García, Adriano Gomes da Cruz, Aarón F. González-Córdova, Simone Guglielmetti, Jonas de Toledo Guimarães, Adrián Hernández-Mendoza, Philippe Langella, Andrea M. Liceaga, Marciane Magnani, Rebeca Martin, Mohammad Tamrin Mohamad Lal, Diego Mora, Mehran Moradi, Lorenzo Morelli, Fabio Mosca, Filomena Nazzaro, Tatiana Colombo Pimentel, Chao Ran, Chaminda Senaka Ranadheera, Maria Rescigno, Azucena Salas, Anderson S. Sant’Ana, Katia Sivieri, Harry Sokol, Valentina Taverniti, Belinda Vallejo-Cordoba, Jaroslav Zelenka, Zhigang Zhou Nature Reviews Gastroenterology and Hepatology, 2021
New complementary and alternative therapies to control methicillin-resistant staphylococcus aureus (MRSA) infection Encyclopedia of Bacteriology Research Developments, 2021
New complementary and alternative therapies to control methicillinresistant staphylococcus aureus (MRSA) infection Methicillin Resistant Staphylococcus Aureus Mrsa Signs Symptoms and Treatment, 2020
Synbiotic yogurts and the elderly Katia Sivieri, Fernanda C. Freire, Natalia P. Lopes, Christiane T.D. Shiraishi, Ana Carolina M.S. Pires, Ana Carolina D. Lima, Adriana C.M. Zavarizi, Letícia Sgarbosa, Fernanda Bianchi Yogurt in Health and Disease Prevention, 2017
Total phenolic compounds of in vitro digestion products of probiotic drink of goat milk, grape juice and grape marc extract Revista De Ciencias Farmaceuticas Basica E Aplicada, 2017
Probiotic fermented soy product stimulated cytokines in rats on a long-term carcinogenic model International Journal of Probiotics and Prebiotics, 2011
Technological aspects of functional foods containing probiotics Maricê Nogueira de Oliveira, Kátia Sivieri, João Henrique Alarcon Alegro, Susana Marta Isay Saad Revista Brasileira De Ciencias Farmaceuticas Brazilian Journal of Pharmaceutical Sciences, 2002
Enhancing the Microbiome in the Mother-Child Dyad: Perspectives from Maternal and Child Nutrition DC Londono-Sierra, SL Restrepo-Mesa, AEC Antunes, K Sivieri, ... ARCHIVOS ARGENTINOS DE PEDIATRIA , 2026 2026
Enhancing the microbiome in the maternal-infant dyad: Perspectives from maternal and infant nutrition DC Londoño-Sierra, SL Restrepo-Mesa, AEC Antunes, K Sivieri, ... Archivos argentinos de pediatria, e202510860 , 2026 2026
Cannabis extract modulates short-chain fatty acid production in fecal microbiota from children with autism spectrum disorder M Oliveira, M Cezaretto, AL Santana, JEC Gomes Filho, MEB Belintani, ... Neuroscience Applied 5, 105909 , 2026 2026
Unconventional food plants from Brazil MK Salgaço, VGS Torres, D de Paulo Farias, FA Carvalho, LL Agostinho, ... The Science and Culture of Latin American Foods, 453-466 , 2026 2026
Altered gut microbiota composition and feeding behaviours in children with Autism Spectrum Disorder: a comparative pilot study M Toscano de Oliveira, MA Borges Scriboni Gonzalez, JV Rosetto Boiate, ... Annals of Human Biology 52 (1), 2535430 , 2025 2025 Citations: 1
Polymeric nanofibers as advanced probiotic carriers: Production strategies, functional performance, and emerging applications Filho, Josemar Goncalves de Oliveira, MB Egea, W Zhang, A Pandi, ... FOOD BIOSCIENCE 73 , 2025 2025
Anti-inflammatory properties of jaboticaba peel bioactive compounds during in vitro gastrointestinal and colonic digestion L Reguengo, AS Saliba, M Salgaço, K Sivieri, S Alencar, MR Maróstica Phytochemistry Letters 69, 103668 , 2025 2025
Polymeric Nanofibers as Advanced Probiotic Carriers: Production Strategies, Functional Performance, and Emerging Applications JG de Oliveira Filho, MB Egea, W Zhang, A Pandi, K Sivieri, MK Salgaço, ... Food Bioscience, 107684 , 2025 2025 Citations: 3
β-Glucan Alone or Combined with Lactobacillus acidophilus Positively Influences the Bacterial Diversity and Metabolites in the Colonic Microbiota of Type II … JR Clementino, LIG de Oliveira, MK Salgaço, FL de Oliveira, V Mesa, ... Probiotics and Antimicrobial Proteins 17 (5), 3728-3742 , 2025 2025 Citations: 10
Exploring the potential use of probiotics, prebiotics, synbiotics, and postbiotics as adjuvants for modulating the vaginal microbiome: a bibliometric review D Xavier-Santos, R Bedani, I de Almeida Vieira, M Padilha, CMG Lima, ... Probiotics and antimicrobial proteins 17 (5), 2732-2769 , 2025 2025 Citations: 10
Polydextrose-driven gut microbiota modulation from synbiotic yogurt intake simulated in the in vitro dynamic multivessel colonic xGI biomics system RC Pessotti, M Salgaço, LL Agostinho, MN de Freitas, CSB Bogsan, ... Frontiers in Nutrition 12, 1654738 , 2025 2025 Citations: 1
Citrus flavonoid supplement enhances glycemic and metabolic control in prediabetic patients on metformin: a randomized controlled trial T Cesar, MR Oliveira, V Sandrim, A Mendes, R Bruder, R Oliveira, ... Frontiers in Nutrition 12, 1639901 , 2025 2025 Citations: 6
Vitamin D3 encapsulated in brewer's spent yeast through vacuum biosorption: Studies on the sorption isotherm, release kinetics into the gastrointestinal system, and colon … BC Soares, T de Jesus Costa, FL de Oliveira, AS Saliba, ... Food Research International 214, 116597 , 2025 2025 Citations: 3
Restoring Balance: Probiotic Modulation of Microbiota, Metabolism, and Inflammation in SSRI-Induced Dysbiosis Using the SHIME ® Model MT de Oliveira, FL de Oliveira, MK Salgaço, V Mesa, A Sartoratto, ... Pharmaceuticals 18 (8), 1132 , 2025 2025 Citations: 9
Exploring the frontiers of psychedelics: a new chromatographic method for detection and quantification of psilocybin and psilocin in Psilocybe cubensis mushrooms T Pereira Galdino, LC Oliveira, MA Luz, R Costa Barbosa, MCM Torres, ... ACS omega 10 (28), 30695-30707 , 2025 2025 Citations: 4
Digestive system simulator apparatus and process CRW Guimarães, MN de Freitas, K Sivieri US Patent App. 18/397,649 , 2025 2025
Effects on Physicochemical and Microbiological Properties of Coconut Water Packaged in Silver‐Based Materials JOD Malafatti, S da Costa Brito, VAC Pereira, Í Calisto, SB Netto, ... Packaging Technology and Science 38 (5), 393-406 , 2025 2025
Bugs got milk? Exploring the potential of lactose as a prebiotic ingredient for the human gut microbiota of lactose-tolerant individuals R de Cassia Pessotti, M Guerville, LL Agostinho, CSB Bogsan, ... Nutrition Research 136, 64-80 , 2025 2025 Citations: 4
Extraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications TP Galdino, LC Oliveira, MA Luz, RA Jesus, EPN Lima, MCM Torres, ... Pharmaceuticals 18 (3), 380 , 2025 2025 Citations: 11
Probióticos e prebióticos: o estado da arte R Bedani, MT Oliveira, MABS Gonzalez, K Sivieri, SMI Saad Microbiota e o eixo intestino-cérebro , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus C Moroti, LF Souza Magri, M de Rezende Costa, DCU Cavallini, K Sivieri Lipids in health and disease 11 (1), 29 , 2012 2012 Citations: 382
Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus MK Salgaço, LGS Oliveira, GN Costa, F Bianchi, K Sivieri Applied microbiology and biotechnology 103 (23), 9229-9238 , 2019 2019 Citations: 213
Agro-industrial by-products: Valuable sources of bioactive compounds LM Reguengo, MK Salgaço, K Sivieri, MRM Júnior Food Research International 152, 110871 , 2022 2022 Citations: 212
Yacon ( Smallanthus sonchifolius ) as a Food Supplement: Health-Promoting Benefits of Fructooligosaccharides BFR Caetano, NA De Moura, APS Almeida, MC Dias, K Sivieri, ... Nutrients 8 (7), 436 , 2016 2016 Citations: 192
Effect of daily consumption of orange juice on the levels of blood glucose, lipids, and gut microbiota metabolites: controlled clinical trials ACD Lima, C Cecatti, MP Fidélix, MAT Adorno, IK Sakamoto, TB Cesar, ... Journal of medicinal food 22 (2), 202-210 , 2019 2019 Citations: 170
Relation between quality and rheological properties of lactic beverages ALB Penna, K Sivieri, MN Oliveira Journal of Food Engineering 49 (1), 7-13 , 2001 2001 Citations: 161
Aspectos tecnológicos de alimentos funcionais contendo probióticos MN Oliveira, K Sivieri, JHA Alegro, SMI Saad Revista Brasileira de Ciências Farmacêuticas 38 (1), 1-21 , 2002 2002 Citations: 158
Postbiotics—When simplification fails to clarify JE Aguilar-Toalá, S Arioli, P Behare, C Belzer, R Berni Canani, JM Chatel, ... Nature Reviews Gastroenterology & Hepatology 18 (11), 825-826 , 2021 2021 Citations: 153
Evidences and perspectives of the use of probiotics, prebiotics, synbiotics, and postbiotics as adjuvants for prevention and treatment of COVID-19: a bibliometric analysis and … D Xavier-Santos, M Padilha, GA Fabiano, G Vinderola, AG Cruz, K Sivieri, ... Trends in Food Science & Technology 120, 174-192 , 2022 2022 Citations: 148
Probiotic Enterococcus faecium CRL 183 inhibit chemically induced colon cancer in male Wistar rats K Sivieri, ALT Spinardi-Barbisan, LF Barbisan, R Bedani, ND Pauly, ... European Food Research and Technology 228 (2), 231-237 , 2008 2008 Citations: 128
Lactobacillus acidophilus CRL 1014 improved “gut health” in the SHIME ® reactor K Sivieri, MLV Morales, MAT Adorno, IK Sakamoto, SMI Saad, EA Rossi BMC gastroenterology 13 (1), 100 , 2013 2013 Citations: 118
Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis NA de Moura, BFR Caetano, K Sivieri, LH Urbano, C Cabello, ... Food and chemical toxicology 50 (8), 2902-2910 , 2012 2012 Citations: 113
Potential contribution of beneficial microbes to face the COVID-19 pandemic AEC Antunes, G Vinderola, D Xavier-Santos, K Sivieri Food research international 136, 109577 , 2020 2020 Citations: 112
Prebiotic Effect of Fructooligosaccharide in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME ® Model) K Sivieri, MLV Morales, SMI Saad, MAT Adorno, IK Sakamoto, EA Rossi Journal of Medicinal Food 17 (8), 894-901 , 2014 2014 Citations: 111
Potentially synbiotic fermented beverage with aqueous extracts of quinoa ( Chenopodium quinoa Willd) and soy F Bianchi, EA Rossi, RG Gomes, K Sivieri Food Science and Technology International 21 (6), 403-415 , 2015 2015 Citations: 100
Modulation of gut microbiota from obese individuals by in vitro fermentation of citrus pectin in combination with Bifidobacterium longum BB-46 F Bianchi, N Larsen, T de Mello Tieghi, MAT Adorno, W Kot, SMI Saad, ... Applied microbiology and biotechnology 102 (20), 8827-8840 , 2018 2018 Citations: 90
An exploratory study on the influence of orange juice on gut microbiota using a dynamic colonic model ALRF Duque, M Monteiro, MAT Adorno, IK Sakamoto, K Sivieri Food Research International 84, 160-169 , 2016 2016 Citations: 87
Gut microbiome approaches to treat obesity in humans F Bianchi, ALRF Duque, SMI Saad, K Sivieri Applied microbiology and biotechnology 103 (3), 1081-1094 , 2019 2019 Citations: 84
Sorvete: composição, processamento e viabilidade da adição de probiótico Ice cream: composition, processing and addition of probiotic JCB Souza, MR Costa, CMVB de Rensis, K Sivieri Alimentos e Nutrição Araraquara 21 (1), 155-165 , 2010 2010 Citations: 80
Microbiota modulation and effects on metabolic biomarkers by orange juice: A controlled clinical trial M Fidélix, D Milenkovic, K Sivieri, T Cesar Food & function 11 (2), 1599-1610 , 2020 2020 Citations: 78
