General Agricultural and Biological Sciences, Multidisciplinary, General Biochemistry, Genetics and Molecular Biology, Animal Science and Zoology
31
Scopus Publications
240
Scholar Citations
7
Scholar h-index
5
Scholar i10-index
Scopus Publications
Understanding the Mechanism of Targeted Therapy- The Next Generation for Cancer Treatment K. R. Padma, K. R. Don, P. Josthna Promising Cancer Therapeutic Drug Targets Recent Advancements, 2025 In recent years, there has been significant progress in understanding the cellular, molecular, and systemic factors that contribute to the development and spread of cancer. This has been made possible by advancements in sequencing methods and data analysis, which have allowed for the identification of various genomic alterations in tumors. While there are currently several specific therapies available, there is a growing focus on target-specific treatments that show better results in cancer treatment. Cancer is widely recognized as the second deadliest disease in the world. For many years, the main forms of treatment for cancer have been chemotherapy and radiotherapy for advanced stages. However, recent advancements in science and technology have led to the discovery of new chemotherapeutic drugs. Additionally, repurposing existing drugs has proven to be a cost-effective strategy for discovering new treatments that target specific cancer regimens and inhibit the growth of cancer cells. The next generation of cancer treatment is largely focused on targeting specific factors that contribute to the development and spread of cancer. This includes therapies that target hypoxia, p53, ERK, and specific proteins through the use of monoclonal antibodies. These treatments have shown promising results in inhibiting the growth of cancer cells and have been effective against various types of cancer. In this article, we will primarily focus on the mechanisms of next-generation therapies and the significance of repurposing drugs. We will also discuss the biology behind targeted cancer treatments and how they work to inhibit the growth of cancer cells.
Aptamers: Promising Tool for Disease Diagnosis and Treatment K. R. Padma, K. R. Don Ceylon Journal of Science, 2025 Aptamers are short, single-stranded DNA or RNA (ssDNA or ssRNA) biomolecules that can selectively attach with specific receptors, including proteins, peptides, carbohydrates, small molecules, hazardous chemicals, and living cells. In the last ten years, aptamers have begun to move away from fundamental research into a variety of industrial applications. The creation of diagnostics is more common than the development of clinical applications since improving the in vivo stability and pharmacokinetics of aptamers for diagnostic tests doesn’t require significant modification. Based on the increased attention, the efficacy of generating aptamers for commercially appealing targets has improved as a result of advances in vitro selection technology `Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Many diseases, including Mycobacterium TB, Treponema pallidum, Novel Coronavirus, HIV, Mucor, and others, revealed substantial menace to people’s well-being and placed significant socioeconomic encumbrance on society. Hence, the initial, as well as precise diagnosis of the pathogen, is crucial for prompt and successful therapy. Due to a lack of reliable probes for identifying the biological markers of infections, detecting human infectious ailments at the molecular as well as nanoscale has been extraordinarily perplexing up to this point. Via the selective growth of ligands by exponential enrichment, a group of plastic oligonucleotides with high specificity and sensitivity known as aptamers are tested in vitro (SELEX). The range of aptamer application situations has expanded significantly with the continued advancement of SELEX-based aptamer screening technologies. This paper reviews the evolution of nucleic acid aptamers in biomedicine with a particular emphasis on how they are used to diagnose infectious diseases. A growing number of pharmaceutical aptamers are currently the subject of preclinical studies or clinical trials. This article discusses the creation and evaluation of therapeutic aptamers for the treatment of various illnesses, including coronavirus. However, the momentous state of aptamer technology suffers from several technical constraints that hinder the passage of innovative aptamers into the clinic and make the aptamer business harder. This review primarily focuses on approaches to overcome obstacles impeding the widespread deployment of aptamers in diagnosis and therapy, as well as tactics that may greatly expand the range of aptamer use and provide future directions to several researchers.
How to Target Mitophagy and Link-Related Pathways in Anticancer Therapy K. R. Padma, K. R. Don Roles of Mitophagy in Cancer Regulation, 2025 Mitophagy the deliberate breakdown of mitochondria by the autophagic pathway is a crucial component of cell-level mitochondrial quality control. Mitophagy, the act of eliminating damaged or malfunctioning mitochondria, is a crucial part of normal cellular physiology and tissue creation. Shared pathways governing mitophagy, cancer, and cell death could be triggered by a solitary upstream signal convening at the mitochondria. We also discuss the pivotal roles that these processes perform in the cancer microenvironment. Recent studies have contributed to the development of anticancer treatments that either promote or inhibit autophagy, shedding light on the role autophagy and related mechanisms play in the initiation and spread of cancer. In this review paper, we have looked at and investigated the different roles that autophagy and related systems play in the development, maintenance, and expansion of malignancies.
The Role of Microbes Influencing the Degradation of Pesticides by Nitrogen-Fixing Bacteria Shaik Gousiya Begam, Kanchi Ravi Padma Journal of Biochemical Technology, 2025 Pesticides, although used in large amounts in agriculture for pest and disease control, have a long-term presence in the soil, bringing about negative impacts on the ecosystems and people. However, one of the possibilities for dealing with the issue is through the microbial degradation of the contaminants, which is a safe and sustainable method for environmental remediation. The study was conducted to find out if the soil bacteria which can fix nitrogen, could also degrade pesticides. The soil s
Pharmacological Insights and Therapeutic Value of Rudraksha: Scientific Review Kanchi RaviPadma, Kanchi Ravi Don Journal of Biochemical Technology, 2025 Rudraksha (Elaeocarpus ganitrus) is a plant that is highly revered and has been found out to be of therapeutic and spiritual value. Traditionally used as the King of Herbal Medicines in use in systems of medicine like Ayurveda, Siddha and Unani systems of medicine, it has been used both prophylactically and as a treatment. As per the mythology of the Hindus, this origin dates back to the Lord Shiva when his tears gave it more spiritual value. Through centuries Rudraksha beads have been attractin
Artificial Intelligence, IOT, and Machine Learning Technologies Introduction in Various Domains K. R. Padma, K. R. Don Intersection of 6g AI Machine Learning and Embedded Systems Pioneering Intelligent Wireless Technologies, 2025 “Artificial intelligence” and “machine learning” have grown in prominence over the past 10 years in various industries, especially information systems. In both academia and business, the two phrases are still occasionally used synonymously, sometimes with distinct implications. In this article, we aim to define the relationship between these concepts. Artificial intelligence (AI) refers to a machine or computer program’s capacity for thinking, learning, and taking action. A subfield of computer science, specifically within the science and information technology department’s computers division, but also in many other sectors, AI is a crucial and popular component. AI applications have benefited individuals in various ways. Machine learning and other AI-related technologies have dramatically increased function quality and efficiency. The appearance of academic and non-academic papers is one of the many societal aspects AI applications significantly impact. We evaluate the relevant research and construct a conceptual framework to define the significance of machine learning in the development of (artificial) intelligent beings. Additionally, we recommend a standard typology for AI-based information systems. We propose an update to a more thorough understanding of the nature of both concepts and greater terminological clarity and direction as a starting point for interdisciplinary conversations in future research.
Medicinal Plants as Neuroprotective Agents in Neurodegenerative Disorders Maneri Sujana, Phallala Tejaswi, Kanchi Ravi Padma, Mohammad Reshma Anjum Sankari Mohan, Penchalaneni Josthna Journal of Biochemical Technology, 2025 Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), present significant global health issues, with existing treatments primarily providing limited symptom relief. Consequently, there is an increasing scientific focus on the neuroprotective capabilities of medicinal plants that have been utilized in various traditional healing practices. This review examines the therapeutic properties of Ginkgo biloba, Crocus sativus
ANTIVIRAL ACTIONS OF CURCUMIN ON ACE2 RECEPTOR, AN EFFICIENT DRUG CANDIDATE AGAINST SARS-CoV-2 Malaysian Journal of Biochemistry and Molecular Biology, 2021
Herbal Plant Uvaria Species and Its Therapeutic Potentiality World Journal of Environmental Biosciences, 2020
A study on coronary heart disease prevention-nutritional status, dietary patterns and life stlye management International Journal of Scientific and Technology Research, 2019
Infusion of adrenomedullin 22-52 antagonist causes uteroimplantation growth restriction during early gestation in rats Drug Invention Today, 2017
RECENT SCHOLAR PUBLICATIONS
Dual-Target Inhibition Strategy Against Dengue Virus: Molecular Docking and Pharmacokinetic Evaluation of Clitoria ternatea Metabolites KR Padma, BT Subhashini, M Sankari 2026
ARTIFICIAL INTELLIGENCE GUIDANCE AS WORKING MODELS FOR IMPLEMENTATION OF UPSKILLING AND RESKILLING IN ORGANIZATIONS. KR Padma Kronika 26 (1), 77-94 , 2026 2026
SHAPING THE FUTURE OF DIETARY BEHAVIORS: INTEGRATING CULTURAL INSIGHTS, EMERGING TECHNOLOGIES, AND SUSTAINABLE FOOD ENVIRONMENTS KR PADMA GASTRONOMY HERITAGE, HEALTH ORIENTATIONS, AND EVOLVING FOOD CULTURES … , 2025 2025
SEX DETERMINATION BY ODONTOMETRIC METHODS–A REVIEW KR DON, C RAMYA, NA BABU, KR PADMA, TA MANGAI, S PS TPM–Testing, Psychometrics, Methodology in Applied Psychology 32 (S5 (2025 … , 2025 2025
CHEILOSCOPY AND HIDDEN LIP PRINT ANALYSIS–A REVIEW KR DON, NA BABU, KMK MASTHAN, KR PADMA, B ISHWARIYA, ... TPM–Testing, Psychometrics, Methodology in Applied Psychology 32 (S5 (2025 … , 2025 2025 Citations: 1
PHOTOGRAPHY IN FORENSICS–A REVIEW KR DON, C RAMYA, NA BABU, KR PADMA, S KOWSALYA, ... TPM–Testing, Psychometrics, Methodology in Applied Psychology 32 (S5 (2025 … , 2025 2025
RACE IDENTIFICATION USING CRANIOFACIAL STRUCTURES AND SKELETAL AND DENTAL TRAITS-A REVIEW KR DON, NA BABU, KMK MASTHAN, KR PADMA, SA RESHMA TPM–Testing, Psychometrics, Methodology in Applied Psychology 32 (S5 (2025 … , 2025 2025
Understanding the Mechanism of Targeted Therapy-The Next Generation for Cancer Treatment KR Padma, KR Don, P Josthna Promising Cancer Therapeutic Drug Targets: Recent Advancements, 223-237 , 2025 2025
Artificial Intelligence, IOT, and Machine Learning Technologies Introduction in Various Domains KR Padma, KR Don The Intersection of 6G, AI/Machine Learning, and Embedded Systems, 254-277 , 2025 2025 Citations: 2
The Role of Microbes Influencing the Degradation of Pesticides by Nitrogen-Fixing Bacteria SG Begam, KR Padma Journal of Biochemical Technology 16 (3-2025), 97-108 , 2025 2025
MOLECULAR INSIGHTS INTO HERBAL HEPATOPROTECTIVES: A PHYTOTHERAPEUTIC APPROACH SSSK K.R. Padma, K.R.Don, M. Reshma Anjum, M. Sankari, C. Gayatri ISARC 9. INTERNATIONAL DİCLE SCIENTIFIC RESEARCH AND INNOVATION CONGRESS 1 … , 2025 2025
Pigments. Bioactive metabolites DC Sankari M, Reshma Anjum M, K. R. Padma, Saathvika B. S., Mouni A Lambert Publications 1, 13-57 , 2025 2025
EXPLORING THE INFLUENCE OF RURAL TOURISM ON CULTURAL HERITAGE AND ITS CONTRIBUTION TO RURAL COMMUNITY DEVELOPMENT KRPKR Don ASES V. INTERNATIONAL KAYSERI SCIENTIFIC RESEARCH CONGRESS. 1, 464-472 , 2025 2025
REVOLUTIONIZING EDUCATION THROUGH AI: RECENT DEVELOPMENTS AND FUTURE DIRECTIONS KRPKR Don INTERNATIONAL SARAJEVO SCIENTIFIC RESEARCH AND INNOVATION CONGRESS BOOK … , 2025 2025
UNDERSTANDING THE RELATIONSHIP OF TOURISM AND HEALTH: CURRENT ISSUES AND FUTURE CONCERNS. MSMS K.R.Padma, K.R.Don, M.Reshma Anjum 2ND INTERNATINAL BEYŞEHİR GASTRONOMY CULTURE AND TOURISM CONGRESS 1, 392-399 , 2025 2025
Formulation And Assessment Of Antimicrobial Activity Of Natural Herbal Soap Against Commercial Market Soap KRP K.Chandana S. Meghana, C. Hemalatha, M. Bhargavi, D. Satwika, P ... Research Journal of Chemistry and Environment 29 (8), 2057-2072 , 2025 2025
A Clinical Study on the Prevalence and Risk Factors of Obstructive Sleep Apnea among Chronic Kidney Disease Patients. AE Yuvaraja Karuppanan, K.M. Bhargav**, K. R. Padma* Journal of Chemical Health Risks 15 (3), 1451-1461 , 2025 2025
FROM CUP TO CURE: SILVER NANOPARTICLES SYNTHESIZED FROM BUTTERFLY PEA AND GINGER HERBAL TEA FOR DIABETES AND OBESITY MANAGEMENT MS V.Bindu*, K.R.Padma, M.Reshma Anjum Research Journal of Chemistry and Environment 29 (6), 1865-1888 , 2025 2025
Green Synthesis of Silver Nanoparticles from Butterfly Pea and Ginger: A Review on Their Anti-Diabetic and Anti-Obesity Potential. TD V.Bindu**, K.R.Padma, M.Reshma Anjum M.Sankari Journal of Chemical Health Risks 15 (4), 161-168 , 2025 2025
Pharmacological Insights and Therapeutic Value of Rudraksha: Scientific Review KRPKR Don Journal of biochemical Technology 16 (2), 93-104 , 2025 2025 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
In vitro wound healing potency of methanolic leaf extract of Aristolochia saccata is possibly mediated by its stimulatory effect on collagen-1 expression. KMS 20. Srinivasa Rao Bolla , Abeer Mohammed Al-Subaie, Reem Yousuf Al ... Heliyon, 1-7 , 2019 2019 Citations: 103
Anti-diabetic activities of Dactylorhizahatagirea leaf extract in 3T3-L1 cell line model Pharmacognosy Magazine 15 (64), 212-217 , 2019 2019 Citations: 16
Application of green energy technology for environmental sustainability KR Padma, KR Don, MR Anjum, GS Sindhu, M Sankari World Journal of Environmental Biosciences 12 (4-2023), 1-7 , 2023 2023 Citations: 14
Artificial neural network applications in analysis of forensic science KR Padma, KR Don Cyber Security and Digital Forensics, 59-72 , 2022 2022 Citations: 13
Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology KRPKRD Manar Fayiz Atoum , * Iran J Pharm Res. 21 (1), 1-10 , 2023 2023 Citations: 10
Herbal Plant Uvaria Species and Its Therapeutic Potentiality. KRDPJ K. R. Padma World Journal of Environmental Biosciences 9 (1), 33-38 , 2020 2020 Citations: 9
Dioscorea villosa Leaf Extract Enhances in vitro Wound Healing and Expression of Extra Cellular Matrix Factors Transforming Growth Factor‑Beta 1 and Collagen‑1 in L929 Cell Lines. Pharmacognosy Magazine 15 (66), s483-s494 , 2019 2019 Citations: 9
Transforming Fish Waste into Highvalue Resources: A Sustainable Approach to Circular Bioeconomy. KHTS K.R. Padma*, M. Reshma Anjum, M. Sankari, K.R. Don, Sandhya Nakka Uttar Pradesh Journal of Zoology 45 (23), 48-59 , 2024 2024 Citations: 6
Antibiotics are current approaches to improve productivity using soil microbiome KR Padma, KR Don, B Dinesh, D Karthikeyan World Journal of Environmental Biosciences 12 (3-2023), 33-39 , 2023 2023 Citations: 6
Effect of Litsea lancifolia Leaf Extract on Glucose Transporter 4 Translocation and Glucose Uptake in 3T3L1 Cell Line. KMS 20. Srinivasa Rao Bolla , Abeer Mohammed Al-Subaie, Reem Yousuf Al ... Journal of Pharmacy and Bioallied sciences 11 (3), 240-247 , 2019 2019 Citations: 6
Application of artificial intelligence to detect and recover contaminated soil: an overview KR Padma, KR Don Advances in Bioremediation and Phytoremediation for Sustainable Soil … , 2022 2022 Citations: 5
Study of antidiabetic properties of Uvaria narum leaf extract through glucose uptake and glucose transporter 4 expression studies in 3T3L1 cell line model. SKM 25. Murad Alsawalha, PB Janardhana, KR Padma, Shiva Shankar Reddy, Abeer ... Pharmacognosy Research Journal 11 (3), 304-309 , 2019 2019 Citations: 4
Medicinal Plants as Neuroprotective Agents in Neurodegenerative Disorders M Sujana, P Tejaswi, KR Padma, MRAS Mohan, P Josthna Journal of Biochemical Technology 16 (3-2025), 37-50 , 2025 2025 Citations: 3
Review article: An overview of exosomes in biology and their potential applications in regenerative medicine KRPKRD Joss James, Janardhana PB Journal of Associated Medical Sciences, 57 (3), 138-154 , 2024 2024 Citations: 3
Emerging hantavirus threats: clinical manifestations and strategies for mitigation KR Padma, KR Don, P Josthna, V Bindu International Journal of Veterinary Research and Allied Sciences 1 (2-2021), 1-9 , 2021 2021 Citations: 3
Infusion of adrenomedullin 22-52 antagonist causes uteroimplantation growth restriction during early gestation in rats. KR Padma, GL Deepika, P Josthna Drug Invention Today 9 (2) , 2017 2017 Citations: 3
ADRENOMEDULLIN: A UBIQUITOUS HORMONE REQUIRED FOR HEALTHY PREGNANCY DPJ K.R.Padma International journal of recent scientific research 7 (6), 11710-11713 , 2016 2016 Citations: 3
Artificial Intelligence, IOT, and Machine Learning Technologies Introduction in Various Domains KR Padma, KR Don The Intersection of 6G, AI/Machine Learning, and Embedded Systems, 254-277 , 2025 2025 Citations: 2
Gut microbiota-estrogen axis: Its influence on female health outcomes – A narrative review. Manar Atoum, Kanchi Ravi Padma Acta Biomedica Atenei Parmensis 96 (1), 15980. , 2025 2025 Citations: 2
Curcumin is a potential therapeutic agent that ameliorates diabetes among non-alcoholic fatty liver disease coexist with type 2 diabetes MF Atoum, KR Padma, KR Don Nutrition and Healthy Aging 9 (1), 77-90 , 2024 2024 Citations: 2
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