Luis Antonio Justulin Jr

Scopus Publications

Renal proteomics of male offspring exposed to maternal protein restriction: molecular, epigenetic, and nephron-specific signatures of metabolic programming
Danielle Amanda Niz Alvarez, Isabelle Tenori Ribeiro, Matheus Naia Fioretto, Marina Pereira Pires, Luisa Annibal Barata, Flávia Alessandra Maciel, Luiz Marcos Frediane Portela, Renato Mattos, Hecttor Sebastian Baptista, Pedro Menchini Vitali¹, Vinicius Alexandre Andrade Felipe, Marcel Rodrigues Ferreira, Elena Zambrano, Patrícia Aline Boer, Luis Antonio Justulin
Journal of Physiology and Biochemistry, 2026
Chronic kidney disease is an increasing global public health concern, and the Developmental Origins of Health and Disease (DOHaD) concept proposes that adverse conditions during critical developmental windows predispose offspring to chronic disorders later in life. Maternal protein restriction (MPR), a well-established experimental model reflecting food insecurity, has been shown to impair nephrogenesis and promote long-term renal dysfunction. In this study, we investigated renal metabolic–epigenetic programming induced by gestational and lactational MPR in post-weaning male rats using a global kidney proteomic approach. MPR altered renal structure and profoundly dysregulated protein networks, characterized by downregulation of energy metabolism, ion transport, cytoskeletal organization, membrane integrity, and mitochondrial function, alongside upregulation of innate immune pathways, glutathione metabolism, vesicular trafficking, and cytoskeletal dynamics. Integrated pathway and disease enrichment analyses revealed the potential risk to hypertension, acid–base imbalance, renal tubular transport disorders, nephrosis, and renal failure. Key differentially expressed proteins (e.g., GPX1, CYCS, ATP1A2/ATP1B1, TUBB/TUBA isoforms, ANPEP, and metabolic enzymes) emerged as potential biomarkers of renal metabolic–epigenetic programming. Collectively, these findings identify molecular signatures that link early-life protein restriction to long-term risk of kidney disease and provide mechanistic insight into the nephron- and cell-specific consequences of MPR.
Placental programming in maternal malnutrition as a crucial determinant of offspring health: A critical-interpretative narrative review
Luisa Annibal Barata, Matheus Naia Fioretto, Natália Magosso, Flávia Alessandra Maciel, Isabelle Tenori Ribeiro, Patrick Vieira de Souza, Ana Luiza Romano Gabriel, Wellerson Rodrigo Scarano, Luis Antonio Justulin
Clinical Nutrition Espen, 2026
Maternal malnutrition during pregnancy is a critical environmental factor that can reprogram placental development and, consequently, influence fetal growth and offspring health across the lifespan. According to the Developmental Origins of Health and Disease (DOHaD) theory, adverse intrauterine conditions - such as nutrient deficiencies or excesses - may induce morphological and functional alterations in the placenta, thereby increasing the risk of chronic noncommunicable diseases (NCDs) in adulthood. This critical-interpretative narrative review compiles evidence on how maternal nutritional disorders, including protein restriction, micronutrient deficiencies, and high-fat diets, compromise placental efficiency by altering nutrient transport, hormonal signaling, and epigenetic regulation. We discuss the interplay between placental dysfunction, impaired fetal development, and increased disease susceptibility in offspring from a sex-specific perspective, highlighting the more adaptive placental responses observed in females and the more pronounced adverse effects and underlying potential pathophysiological pathways in males. Drawing on established studies, we synthesize insights and potential molecular and biochemical mechanisms of placental dysregulation, and propose new directions for research that address not only the consequences for offspring and metabolic programming but also the implications for women's health during critical periods, such as pregnancy. From a DOHaD perspective, this review underscores the central role of the placenta as a mediator between the intrauterine environment and health outcomes, pointing toward preventive strategies and future research approaches.
Nanoplastic-driven white pollution: Biochemical insights into ecosystem and human health impacts - a critical-interpretative narrative review
Matheus Naia Fioretto, Natália Magosso, Patrick Vieira de Souza, Mirella Franco Moreira, Vanessa Aguiar Rocha, Victória Cristina Pinha, Vinicius Luís Rocha da Silva Maria, Luis Antonio Justulin, Wellerson Rodrigo Scarano
Biochimie, 2026
Plastic production has become a global challenge, and its accelerated growth and widespread waste release justify the characterization of the current era as the "Age of Plastic". The concern is how additives or plastic degradation can impact different ecosystems and human health. Microplastics and certain plastic additives (e.g., phthalates) are already well-established in the literature as endocrine disruptors, posing a risk to human health. However, little is known about these issues regarding Nanoplastics (NPs). Therefore, this narrative review aimed to examine the potential biochemical disruptions induced by NPs across multiple organs and biological systems, while also considering their ecological, ecosystem-level, and human health risks. The NPs affect mitochondria and endoplasmic reticulum in experimental models and across various organs, affecting lipid, energy, and amino acid metabolism. In the environmental context, NPs can interfere with xylem/phloem transport, root absorptive function, and photosynthesis in both terrestrial and aquatic models. This raises concerns not only at the ecological levels, but also for production and the economy, with potential risks to human health through food. This review strengthens the understanding of environmental toxicology and the imminent risks of NPs on various ecosystems, highlighting the disruptions of these nanomolecules, whether isolated or adsorbed, to important catalytic pathways and metabolic pathways in an organ-wide manner.
Understanding Intracellular Transport Impairments in Maternal Protein Restriction: A Scoping Review of DOHaD-Driven Cellular Biology Perspective
Matheus Naia Fioretto, Isabelle Tenori Ribeiro, Maria Clara Caruso Corso, Sofia Francisco Tellaroli, Carla Beatriz Correa de Souza, Wellerson Rodrigo Scarano, Luis Antonio Justulin
Cell Biochemistry and Biophysics, 2026
Malnutrition remains a major global socioeconomic challenge. When it occurs during critical developmental windows (pregnancy and lactation), it can impair maternal health and predispose offspring to long-term diseases, a central concept within the Developmental Origins of Health and Disease (DOHaD). Maternal Protein Restriction (MPR) is a widely used experimental model in this field and is known to disrupt multiple organs and systems in the offspring, increasing susceptibility to metabolic disorders. However, the cellular pathways underlying these outcomes remain insufficiently explored, particularly vesicular transport and the endomembrane system. This review examined the effects of MPR on organelles related to vesicular dynamics. Following predefined inclusion and exclusion criteria, 20 PubMed articles were selected, addressing MPR-induced alterations in the cytoskeleton, endoplasmic reticulum (ER), Golgi, endocytosis, and exocytosis. Overall, evidence indicates that MPR disrupts cytoskeletal integrity—affecting actin networks in renal, adipose, muscle, and neural cells. MPR compromises ER and Golgi activities in several organs. In the placenta, endocytic activity was consistently elevated (macropinocytosis). Exocytosis was also perturbed, contributing to lipid accumulation and inflammation. Systemically, MPR altered circulating amino acid levels, impaired hematological parameters, reduced leukocyte migration, and enhanced placental amino acid transport. These findings demonstrate that MPR destabilizes cytoskeletal architecture, ER–Golgi function, and vesicular transport across multiple offspring tissues, identifying the endomembrane system as a critical target of developmental programming. These alterations suggest persistent vulnerabilities in cellular homeostasis. Therefore, we propose the term maternal diet–dependent cellular-vesicular disorders (MDCVD), establishing a conceptual framework for future mechanistic and translational studies.
Phytochemical frontiers and molecular targets in liver cancer: A systematic bibliometric curation of natural compounds for HCC therapy (2015–2025)
Fábio Rodrigues Ferreira Seiva, Milena Cremer de Souza, Wesley Ladeira Caputo, Maria Luisa Gonçalves Agneis, Matheus Ribas de Almeida, et al.
Biomedicine and Pharmacotherapy, 2026
Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited treatment options. While natural products offer a vast chemical space for drug discovery, the literature at the oncology-phytochemistry interface remains fragmented. This study provides a high-resolution bibliometric curation to map research trends and pharmacological hotspots in HCC therapy over the last decade. A systematic search was conducted via Scopus for studies published between 2015 and 2025. Following manual curation of 1477 eligible articles, VOSviewer and the Bibliometrix R-package were utilized for analysis. A distinctive feature was the integration of taxonomic validation and manual text mining to ensure high accuracy of botanical and phytochemical data. Our findings reveal an exponential growth in scientific production, led by China, the USA, and India. The editorial landscape spans over 400 journals and 90 publishers, such as Elsevier, Frontiers, MDPI and Wiley. Phytomedicine and Journal of Ethnopharmacology were the most prolific journals. We identified over 700 distinct phytochemicals, notably quercetin, curcumin, and resveratrol, and approximately 600 plant species. Thematic clustering demonstrated that these compounds modulate critical cellular events, including apoptosis, oxidative stress, cell-cycle checkpoints, epithelial-mesenquimal transition, and distinct but complementary signaling pathway, such as Bax-Bcl-2, PI3K/Akt, mTOR, VEGF, SIRT1/NRF2, MAPK/ERK, CHOP and GRP78, and also different classes of miRNAs. Nanotechnology-based delivery systems emerged as a major trend to overcome bioavailability challenges. This bibliometric curation provides a mapping of the field, identifying critical thematic transitions and current knowledge gaps. The systematic cataloging of authors, institutions, publishers, journals, and phytochemicals offers a foundation for prioritizing molecules in future trials, providing objective insights for drug discovery and potential novel targeted therapies for HCC.
Protein Restriction During Pregnancy and Lactation Triggers Steatohepatitis and Adrenal Disorders in Rat Dams: Insights into Maternal Metabolic Health
Luísa Annibal Barata, Matheus Naia Fioretto, Vinícius Alexandre de Andrade Felipe, Patrick Vieira de Souza, Isabelle Tenori Ribeiro, Flávia Alessandra Maciel, Luiz Marcos Frediani Portela, Mirella Franco Moreira, Gustavo Monezzi Cordeiro, Ana Lívia Silvério Vieira, Wellerson Rodrigo Scarano, Elena Zambrano, Luis Antonio Justulin
Archives of Medical Research, 2026
Omics-based molecular signatures of adrenal, kidney, and lung development in male rat offspring exposed to maternal protein restriction
Matheus N. Fioretto, Marcel R. Ferreira, Gabriel H. Caxali, Patrick V. de Souza, Flávia A. Maciel, Isabelle T. Ribeiro, Luisa A. Barata, Ana Lívia S. Vieira, Marina P. Pires, Lucas S. Lemos, Renato Mattos, Flávia K. Delella, Wellerson R. Scarano, Elena Zambrano, Luis A. Justulin
Clinical Nutrition, 2026
BACKGROUND AND AIMS: Maternal malnutrition remains a global social and public health challenge, with long-lasting effects on offspring's health, as proposed by the Developmental Origins of Health and Disease (DOHaD) theory. Here, we investigated the impact of maternal protein restriction (MPR) during gestation and lactation on the global proteomic profiles of the kidneys, lungs, and adrenal glands in post-weaning male rats. METHODS: Using in silico strategies applied to the proteomic profile, integrating curated databases and complementary statistical approaches, we performed a multiscale biological mapping encompassing macrobiological processes (biological pathways), microbiological levels (cellular, molecular, biochemical, and nuclear features), developmental disease susceptibility, epigenetic regulation, and cell-type-specific localization of shared biomarkers, which were further supported by gene expression validation. RESULTS: Thirty-six differentially expressed proteins (DEP) were commonly dysregulated across the three organs, enriching pathways related to cellular transport, stress response, chaperone, amino acid metabolism, pyruvate metabolism, the Krebs cycle, and cell cycle regulation (adjusted p-value <0.05). Enrichment analyses indicated alterations in cytoskeletal and nuclear components, with molecular functions involving GTP binding, nucleoside activity, ubiquitination, RNA processing, and redox homeostasis (p < 0.05). Biochemical pathways highlighted disruptions in NAD/NADH balance, energy metabolism, oxygen transport, and purine/pyrimidine metabolism (based on p-value and FDR), with chromosomal enrichment. Interaction networks revealed clusters involving cytoskeletal organization, hemostasis, and energy metabolism, with strong epigenetic associations involving miR-3064-3p/3065-3p (TUBA1A), miR-350/3585-5p (MDH1), and miR-455-3p/92a-1-5p (H2AZ1). These three proteins emerged as potential early-life molecular markers of MPR. CONCLUSIONS: Overall, this study provides a systems-level overview of MPR effects on adrenal, kidney, and lung development, identifying shared proteomic signatures and candidate biomarkers predictive of developmental impairment and long-term risk for chronic metabolic disease.
Gestational and lactational exposure to phthalates and nanoplastics induces inflammation and oxidative imbalance in the prostate of adult rats
Vanessa A Rocha, Marina Cavalheiro, Patrick V Souza, Natalia Magosso, Matheus N Fioretto, Mirella F Moreira, Victoria C Pinha, Ariana M Aquino, Debora H Quadreli, Glaura S A Fernandes, Luis A Justulin, Jodi A Flaws, Wellerson R Scarano
Toxicological Sciences an Official Journal of the Society of Toxicology, 2026
The intrauterine microenvironment is highly susceptible to environmental disturbances, which may result in persistent effects on offspring health. Given that plastic-derived contaminants can cross the placental barrier and act as endocrine-disrupting chemicals, this study evaluated the effects of perinatal exposure to an environmentally relevant phthalate mixture (PM) and nanoplastics (NPs) on the prostate of adult rats. Pregnant Sprague–Dawley rats were allocated into 6 experimental groups: Ctrl (vehicle), T1 (20 μg/kg/d PM), T2 (200 mg/kg/d PM), T3 (NPs: 1.0 mg/kg/d), T4 (20 μg PM + NPs), and T5 (200 mg PM + NPs). Treatments were administered orally from gestational day 10 to postnatal day (PND) 21. Male offspring were euthanized on PND120, and ventral prostate samples were collected. Histological evaluation revealed increased inflammatory foci and stromal expansion in all exposed groups (T1–T5), along with reduced luminal compartment in T1, T3, and T4 compared with controls. All treated groups showed increased total and degranulated mast cells and enhanced androgen receptor immunoreactivity. Tumor necrosis factor (Tnf) expression was increased in all exposure groups, whereas Rela gene expression was elevated in the T4 and T5 groups. Oxidative stress analysis demonstrated increased lipid peroxidation and glutathione S-transferase (GST) activity in all treated animals. Catalase (CAT) activity was reduced in T1, T3, and T5, whereas superoxide dismutase (SOD) activity increased in T3, T4, and T5. Elevated levels of reduced, oxidized, and total glutathione (GSH, GSSG, tGSH) were observed in T5. Overall, perinatal exposure to PM and NPs induced persistent inflammation and altered redox status in the prostate, increasing susceptibility to pathological disorders.
Review: The Protective Impact of Supplementation and Exercise against Maternal Malnutrition: Environment as a Key Determinant of Health or Disease
Matheus Naia Fioretto, Isabelle Tenori Ribeiro, Luis Antonio Justulin
Cell Biochemistry and Biophysics, 2026
Endocrine programming of the pituitary–thyroid–adrenal axis: Sex-Specific effects of maternal malnutrition in rats
Ana Lívia Silvério Vieira, Gustavo Monezzi Cordeiro, Vinicius Alexandre de Andrade Felipe, Matheus Naia Fioretto, Luísa Annibal Barata, Marina Pereira Pires, Pedro Menchini Vitali, Renato Mattos, Isabelle Tenori Ribeiro, Flávia Alessandra Maciel, Hecttor Sebastian Baptista, Luis Antonio Justulin
Molecular and Cellular Endocrinology, 2026
Metabolic insights into male fertility: a narrative review of the role of adiponectin on the hypothalamic–pituitary–testicular axis
Ana Luiza Romano Gabriel, Matheus Naia Fioretto, Luisa Annibal Barata, Luis Antonio Justulin, Sergio Luis Felisbino
Biology of Reproduction, 2026
Maternal Phthalate Exposure Alters Prostate Proteome in Rat Offspring: Linking Omics Insights to Prostate Cancer Risk in Humans
Patrick Vieira Souza, Ariana Musa Aquino, Luiz Guilherme Alonso-Costa, Natália Magosso, Marcos Antonio Fernandes de Oliveira, Vanessa Aguiar Rocha, Matheus Naia Fioretto, Mirella Franco Moreira, Victória Cristina Pinha, Gabriel Henrique Caxali, Luis Antônio Justulin, Jodi Anne Flaws, Wellerson Rodrigo Scarano
Archives of Medical Research, 2026
Current insights into the impact of plastic-derived pollutants (phthalates), microplastics, and nanoplastics on hypothalamic phenotype and molecular pathways: A scoping review
Matheus Naia Fioretto, Victória Cristina Pinha, Carolina Beatriz Pinheiro Basso, Patrick Vieira de Souza, Natália Magosso, Mirella Franco Moreira, Vanessa Aguiar Rocha, Luis Antonio Justulin, Wellerson Rodrigo Scarano
Environmental Pollution, 2026
Supplementation with inorganic iron has no impact on the morphology of the hypopharyngeal glands in honey bees (Apis mellifera L.)
Alex Junji Shinohara, Thaís de Souza Bovi, Guilherme Duarte Figueiredo de Souza, Daniel Nicodemo, Luis Antônio Justulin Júnior, Ricardo de Oliveira Orsi
Acta Scientiarum Animal Sciences, 2026
Correction: Peroxiredoxins in the Developmental Origins of Health and Disease: Insights from Maternal Under and Overnutrition – A Critical-Interpretative Scoping Review (Cell Biochemistry and Biophysics, (2026), 10.1007/s12013-026-02061-9)
Matheus Naia Fioretto, Luísa Correia Gomes, Flávia Alessandra Maciel, Ana Luiza Silva de Abreu, Ana Luiza Romano Gabriel, Sérgio Luis Felisbino, Luis Antonio Justulin
Cell Biochemistry and Biophysics, 2026
Peroxiredoxins in the Developmental Origins of Health and Disease: Insights from Maternal Under and Overnutrition – A Critical-Interpretative Scoping Review
Matheus Naia Fioretto, Luísa Correia Gomes, Flávia Alessandra Maciel, Ana Luiza Silva de Abreu, Ana Luiza Romano Gabriel, Sérgio Luis Felisbino, Luis Antonio Justulin, Matheus Naia Fioretto
Cell Biochemistry and Biophysics, 2026
Maternal Exposure to an Environmentally Relevant Phthalate Mixture Modulates the Steroidogenic Genes in the Adrenal Glands Throughout Postnatal Development of Male Rats
Natália Magosso, Patrick Vieira de Souza, Ariana Musa Aquino, Vanessa Aguiar Rocha, Matheus Naia Fioretto, Luiz Guilherme Alonso Costa, Silvana Gisele Pegorin de Campos, Luiz Fernando Barbisan, Luis Antonio Justulin, Jodi A. Flaws, Wellerson Rodrigo Scarano
Environmental Toxicology, 2025
Early and long-term effects of maternal protein restriction on offspring organs and systems: insights from the developmental origins of health and disease (DOHaD)
Matheus Naia Fioretto, Luisa Annibal Barata, Isabelle Tenori Ribeiro, Flávia Alessandra Maciel, Renato Mattos, Patrick Vieira de Souza, Luiz Marcos Frediane Portela, Sérgio Alexandre Alcântara dos Santos, Wellerson Rodrigo Scarano, Luis Antonio Justulin
Biogerontology, 2025
Maternal protein restriction compromises hepatic phenotype and antioxidant defense in postweaning male rats, while females exhibit resilience
André Matheus Leandro Franzolin, Matheus Naia Fioretto, Isabelle Tenori Ribeiro, Flávia Alessandra Maciel, Luisa Annibal Barata, Pedro Menchini Vitali, Natália Magosso, Felipe Leonardo Fagundes, Maycon Tavares Emílio-Silva, Clélia Akiko Hiruma Lima, Wellerson Rodrigo Scarano, Luis Antonio Justulin
Biochemical and Biophysical Research Communications, 2025
Maternal malnutrition induces inflammatory pathways and oxidative stress in the dorsolateral prostate of male offspring rats
Renato Mattos, Matheus Naia Fioretto, Sérgio Alexandre Alcantara dos Santos, Isabelle Tenori Ribeiro, Maycon Tavares Emílio-Silva, Luiz Marcos Frediani Portela, Clélia Akiko Hiruma Lima, Fabio Rodrigues Ferreira Seiva, Luis A. Justulin
Biogerontology, 2025
Long-term effects of maternal protein restriction on adrenal proteomic profile and steroidogenesis in male offspring rats
Matheus Naia Fioretto, Luísa Annibal Barata, Vinícius Alexandre de Andrade Felipe, Sérgio Alexandre Alcantara dos Santos, Flávia Alessandra Maciel, Isabelle Tenori Ribeiro, Renato Mattos, Hecttor Sebástian Baptista, Gabriela Bueno, Felipe Leonardo Fagundes, Luiz Marcos Frediane Portela, Wellerson Rodrigo Scarano, Fábio Rodrigues Ferreira Seiva, Clélia Akiko Hiruma Lima, Luis Antonio Justulin
Cellular Signalling, 2025
A high-fat diet changes the interaction of the extracellular matrix, cytokines, and growth factors in gastric ulcer repair
Rie Ohara, Felipe Lima Dario, Maycon Tavares Emílio-Silva, Renata Assunção, Vinícius Peixoto Rodrigues, Gabriela Bueno, Priscila Romano Raimundo, Luis Antonio Justulin, Lúcia Regina Machado da Rocha, Clelia Akiko Hiruma-Lima
Biochemical and Biophysical Research Communications, 2025
Maternal protein restriction and postnatal sugar consumption increases inflammatory response and deregulates metabolic pathways in the liver of male offspring rats with aging
Isabelle Tenori Ribeiro, Matheus Naia Fioretto, Sérgio Alexandre Alcantara dos Santos, Marcus Vinicius Niz Alvarez, Luiz Marcos Frediani Portela, Renato Mattos, Hecttor Baptista Sebastian, Pedro Menchini Vitali, Fábio Rodrigues Ferreira Seiva, Luís Fernando Barbisan, Clélia Akiko Hiruma Lima, Débora Cristina Damasceno, Elena Zambrano, Luis Antonio Justulin
Molecular and Cellular Endocrinology, 2025
Aerobic exercise acts differentially on proteins from glucose and glycogen pathways in the SOL and PL muscles of offspring rats submitted to a low-protein maternal diet
Jéssica Silvino Valente, Ketlin Thassiani Colombelli, Lucas Lins Pereira, Érika Stefani Perez, Bruna Tereza Thomazini Zanella, Aislan Quintiliano Delgado, Matheus Naia Fioretto, Carlos Roberto Padovani, Ivan José Vechetti, Débora Cristina Damasceno, Luis Antonio Justulin, Maeli Dal-Pai-Silva
Biochemical and Biophysical Research Communications, 2025
Maternal protein restriction impairs intestinal morphophysiology and antioxidant system in young male offspring rats
Isabela Baptista Leal dos Santos, Matheus Naia Fioretto, Miguel Silingardi Jorge, Luísa Annibal Barata, Isabelle Tenori Ribeiro, André Matheus Leandro Franzolin, Erick Guilherme Stoppa, Renato Mattos, Luiz Marcos Frediane Portela, Maycon Tavares Emílio Silva, Sérgio Alexandre Alcântara dos Santos, José Ricardo de Arruda Miranda, Clélia Akiko Hiruma Lima, Luis Antonio Justulin
Experimental Cell Research, 2025
Maternal hyperglycemia and postnatal high-fat diet impair metabolic regulation and autophagy response in the liver of adult female rats
Larissa Lopes da Cruz, Yuri Karen Sinzato, Verônyca Gonçalves Paula, Matheus Naia Fioretto, Franciane Quintanilha Gallego, Vinícius Soares Barco, Ana Carolina Lima Camargo, José Eduardo Corrente, Luis Antonio Justulin, Tiago Rodrigues, Gustavo Tadeu Volpato, Débora Cristina Damasceno
Journal of Developmental Origins of Health and Disease, 2025
Long Noncoding RNAs Responding to Ethanol Stress in Yeast Seem Associated with Protein Synthesis and Membrane Integrity
Amanda Piveta Schnepper, Agatha M. S. Kubo, Camila Moreira Pinto, Ramon Hernany Martins Gomes, Matheus Naia Fioretto, Luís Antonio Justulin, Aline M. M. Braz, Marjorie de Assis Golim, Rejane M. T. Grotto, Guilherme Targino Valente
Genes, 2025
Type I and type III collagen immunoexpression in rabbit skin biopsy samples treated with rosuvastatin gel and autologous platelet-rich plasma
Cristoffer da Silva Santana, M. R. S. Breda, Yuri Ferreira Vicentini, S. A. A. Santos, L. A. Justulin, Anthony César de Souza Castilho, Gisele Albonguetti Nai, C. L. Santarém
Acta Cirurgica Brasileira, 2025
Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds
Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Rafael Henrique Nóbrega
Frontiers in Bioengineering and Biotechnology, 2025
Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation
Maycon Tavares Emílio-Silva, Vinicius Peixoto Rodrigues, Mariana Moraes Fioravanti, Antonio Jesús Ruiz-Malagon, Matheus Naia Fioretto, Priscila Romano Raimundo, Rie Ohara, Renata Assunção, Gabriela Bueno, Felipe Lima Dario, Luis Antonio Justulin, Alba Rodríguez-Nogales, Lucia Regina Machado da Rocha, Júlio Gálvez, Clélia Akiko Hiruma-Lima
Frontiers in Pharmacology, 2025
Influence of aging and maternal protein restriction on PIWI-interacting RNA expression in the offspring rat ventral prostate
Hecttor S. Baptista, Luiz M. Frediani Portela, Matheus N. Fioretto, Renato Mattos, Isabelle T. Ribeiro, Ana B. Leite Lorente, Jordana I. Nascimento Oliveira, Luis A. Justulin
Scientific Reports, 2024
In Silico Analysis of Non-Conventional Oxidative Stress-Related Enzymes and Their Potential Relationship with Carcinogenesis
Fábio Rodrigues Ferreira Seiva, Maria Luisa Gonçalves Agneis, Matheus Ribas de Almeida, Wesley Ladeira Caputo, Milena Cremer de Souza, Karoliny Alves das Neves, Érika Novais Oliveira, Luis Antônio Justulin, Luiz Gustavo de Almeida Chuffa
Antioxidants, 2024
Maternal protein restriction combined with postnatal sugar consumption alters liver proteomic profile and metabolic pathways in adult male offspring rats
Isabelle Tenori Ribeiro, Matheus Naia Fioretto, Sérgio Alexandre Alcantara dos Santos, Ketlin Thassiani Colombelli, Luiz Marcos Frediani Portela, Marcus Vinicius Niz Alvarez, Pedro de Magalhães Padilha, Aislan Quintiliano Delgado, Marcus Vinicius Lage Silva Giaculi Marques, José Roberto Bosqueiro, Fábio Rodrigues Ferreira Seiva, Luís Fernando Barbisan, Antonio Marcus de Andrade Paes, Elena Zambrano, Luis Antonio Justulin
Molecular and Cellular Endocrinology, 2024
Impact of maternal protein restriction on the proteomic landscape of male rat lungs across the lifespan
Matheus Naia Fioretto, Flávia Alessandra Maciel, Luísa Annibal Barata, Isabelle Tenori Ribeiro, Carolina Beatriz Pinheiro Basso, Marcel Rodrigues Ferreira, Sérgio Alexandre Alcantara dos Santos, Renato Mattos, Hecttor Sebastian Baptista, Luiz Marcos Frediane Portela, Pedro Magalhães Padilha, Sérgio Luis Felisbino, Wellerson Rodrigo Scarano, Elena Zambrano, Luis Antonio Justulin
Molecular and Cellular Endocrinology, 2024
Vascular smooth muscle cells exhibit elevated hypoxia-inducible Factor-1α expression in human blood vessel organoids, influencing osteogenic performance
Geórgia da Silva Feltran, Rodrigo Augusto da Silva, Célio Junior da Costa Fernandes, Marcel Rodrigues Ferreira, Sérgio Alexandre Alcântara dos Santos, Luis Antônio Justulin Junior, Liliana del Valle Sosa, Willian Fernando Zambuzzi
Experimental Cell Research, 2024
Insulin signaling and mitochondrial phenotype of skeletal muscle are programmed in utero by maternal diabetes
Eduardo Klöppel, Larissa L. Cruz, Laura F.L. Prado-Souza, Adam Eckhardt, José E. Corrente, Daniela C. dos Santos, Luís A. Justulin, Tiago Rodrigues, Gustavo T. Volpato, Débora C. Damasceno
Molecular and Cellular Endocrinology, 2024
Maternal malnutrition associated with postnatal sugar consumption increases inflammatory response and prostate disorders in rat offspring
Matheus Naia Fioretto, Ketlin Thassiani Colombelli, Cecilia Luvizutti Ferreira da Silva, Sérgio Alexandre Alcantara dos Santos, Ana Carolina Lima Camargo, Flávia Bessi Constantino, Luiz Marcos Frediani Portela, Ariana Musa de Aquino, Luisa Annibal Barata, Renato Mattos, Wellerson Rodrigo Scarano, Elena Zambrano, Luis Antonio Justulin
Molecular and Cellular Endocrinology, 2024
In silico investigation of the role of miRNAs in a possible developmental origin of prostate cancer in F1 and F2 offspring of mothers exposed to a phthalate mixture
A. M. Aquino, M. N. Fioretto, L. G. Alonso‐Costa, V. A. Rocha, P. V. Souza, N. Magosso, L. F. Barbisan, L. A. Justulin, J. A. Flaws, W. R. Scarano
Environmental Toxicology, 2024
The joint action of yeast eisosomes and membraneless organelles in response to ethanol stress
Camila Moreira Pinto, Amanda Piveta Schnepper, Pedro Henrique Esteves Trindade, Luiz Henrique Cardoso, Matheus Naia Fioretto, Luís Antônio Justulin, Cleslei Fernando Zanelli, Guilherme Targino Valente
Heliyon, 2024
Deregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats
Ana CL. Camargo, Flávia B. Constantino, Sergio AA. Santos, Ketlin T. Colombelli, Luiz MF. Portela, Matheus N. Fioretto, Luísa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Molecular and Cellular Endocrinology, 2024
Non-invasive biomagnetic assessment of gastrointestinal motility in a loperamide-induced constipation model
Erick Guilherme Stoppa, Guilherme Augusto Soares, Lais Pereira Buranello, Luiz Marcos Frediani Portela, Luiz Antônio Justulin, Madileine Francely Américo, Luiz Claudio Di Stasi, José Ricardo de Arruda Miranda
Brazilian Journal of Pharmaceutical Sciences, 2024
Early-life origin of prostate cancer through deregulation of miR-206 networks in maternally malnourished offspring rats
Luiz M. F. Portela, Flavia B. Constantino, Ana C. L. Camargo, Sérgio A. A. Santos, Ketlin T. Colombelli, Matheus N. Fioretto, Luísa A. Barata, Erick J. R. Silva, Wellerson R. Scarano, Sergio L. Felisbino, Carlos S. Moreno, Luis A. Justulin
Scientific Reports, 2023
Integrated transcriptome and proteome analysis indicates potential biomarkers of prostate cancer in offspring of pregnant rats exposed to a phthalate mixture during gestation and lactation
A.M. Aquino, L.G. Alonso-Costa, S.A.A. Santos, V.A. Rocha, L.F. Barbisan, A. Bedrat, L.A. Justulin, J.A. Flaws, B. Lemos, W.R. Scarano
Chemosphere, 2023
Zinc methionine or zinc sulphate supplementation modulate the development of the hypopharyngeal gland and expression of major royal jelly protein genes in Apis mellifera L. bees
Giovanna do Prado Ribeiro, Samir Moura Kadri, Luis Antônio Justulin, Paulo Eduardo Martins Ribolla, Ricardo de Oliveira Orsi
Physiological Entomology, 2023
2,4-dichlorophenoxyacetic acid (2,4-D) exposure during postnatal development alters the effects of western diet on mouse prostate
V.A. Rocha, A.M. Aquino, N. Magosso, P.V. Souza, L.A. Justulin, R.F. Domeniconi, L.F. Barbisan, G.R. Romualdo, W.R. Scarano
Reproductive Toxicology, 2023
Hyperglycemic microenvironment compromises the homeostasis of communication between the bone-brain axis by the epigenetic repression of the osteocalcin receptor, Gpr158 in the hippocampus
Ericka Patricia da Silva, Geórgia da Silva Feltran, Sérgio Alexandre Alcântara dos Santos, Rodrigo Cardoso de Oliveira, Rahyza I.F. Assis, Luis Antônio Justulin Junior, Denise Carleto Andia, Willian F. Zambuzzi, Alexandra Latini, Rodrigo A. Foganholi da Silva
Brain Research, 2023
Integrative Analysis of the Ethanol Tolerance of Saccharomyces cerevisiae
Ivan Rodrigo Wolf, Lucas Farinazzo Marques, Lauana Fogaça de Almeida, Lucas Cardoso Lázari, Leonardo Nazário de Moraes, Luiz Henrique Cardoso, Camila Cristina de Oliveira Alves, Rafael Takahiro Nakajima, Amanda Piveta Schnepper, Marjorie de Assis Golim, Thais Regiani Cataldi, Jeroen G. Nijland, Camila Moreira Pinto, Matheus Naia Fioretto, Rodrigo Oliveira Almeida, Arnold J. M. Driessen, Rafael Plana Simōes, Mônica Veneziano Labate, Rejane Maria Tommasini Grotto, Carlos Alberto Labate, Ary Fernandes Junior, Luis Antonio Justulin, Rafael Luiz Buogo Coan, Érica Ramos, Fabiana Barcelos Furtado, Cesar Martins, Guilherme Targino Valente
International Journal of Molecular Sciences, 2023
Editorial: Early Life Epigenetic Programming of Health and Disease through DOHaD Perspective
Luis A. Justulin, Elena Zambrano, Thomas P. Ong, Susan E. Ozanne
Frontiers in Cell and Developmental Biology, 2023
miR-18a-5p Is Involved in the Developmental Origin of Prostate Cancer in Maternally Malnourished Offspring Rats: A DOHaD Approach
Sergio Alexandre Alcantara Santos, Luiz Marcos Frediani Portela, Ana Carolina Lima Camargo, Flavia Bessi Constantino, Ketlin Thassiani Colombelli, Matheus Naia Fioretto, Renato Mattos, Bruno Evaristo de Almeida Fantinatti, Michela Alessandra Denti, Silvano Piazza, Sérgio Luis Felisbino, Elena Zambrano, Luis Antonio Justulin
International Journal of Molecular Sciences, 2022
Effects of a phthalate metabolite mixture on both normal and tumoral human prostate cells
Alexandre M. B. Cavalca, Ariana M. Aquino, Francielle C. Mosele, Luis A. Justulin, Flávia K. Delella, Jodi A. Flaws, Wellerson R. Scarano
Environmental Toxicology, 2022
Bisphenol A and 2,3,7,8-tetrachlorodibenzo-p-dioxin at non-cytotoxic doses alter the differentiation potential and cell function of rat adipose-stem cells
Helga Caputo Nunes, Samara Costa Tavares, Heloísa Vicente Garcia, Maira Smaniotto Cucielo, Sérgio Alexandre Alcântara dos Santos, Mirian Carolini Esgoti Aal, Marjorie Assis de Golim, Luís Antônio Justulin, Amanda Oliveira Ribeiro, Elenice Deffune, Wellerson Rodrigo Scarano, Flávia Karina Delella
Environmental Toxicology, 2022
Prostate Cancer Secretome and Membrane Proteome from Pten Conditional Knockout Mice Identify Potential Biomarkers for Disease Progression
Nilton J. Santos, Ana Carolina Lima Camargo, Hernandes F. Carvalho, Luis Antonio Justulin, Sérgio Luis Felisbino
International Journal of Molecular Sciences, 2022
Maternal Low-Protein Diet Deregulates DNA Repair and DNA Replication Pathways in Female Offspring Mammary Gland Leading to Increased Chemically Induced Rat Carcinogenesis in Adulthood
Joyce R. Zapaterini, Antonio R. B. Fonseca, Lucas T. Bidinotto, Ketlin T. Colombelli, André L. D. Rossi, Laura Kass, Luis A. Justulin, Luis F. Barbisan
Frontiers in Cell and Developmental Biology, 2022
THE ROUND LIGAMENT IN DEVELOPMENTAL HIP DYSPLASIA: ARE ITS MECHANICAL AND HISTOLOGICAL PROPERTIES PRESERVED?
ALEXANDRE ZUCCON, HAMILTON DA ROSA PEREIRA, SÉRGIO ALEXANDRE ALCÂNTARA DOS SANTOS, SÉRGIO LUÍS FELISBINO, LUÍS ANTÔNIO JUSTULIN JUNIOR, DANIELE CRISTINA CATANEO
Acta Ortopedica Brasileira, 2022
Effect of organic and inorganic zinc supplementation on the development of mandibular glands in apis mellifera
Bulletin of Insectology, 2021
Prediction of Non-canonical Routes for SARS-CoV-2 Infection in Human Placenta Cells
Flávia Bessi Constantino, Sarah Santiloni Cury, Celia Regina Nogueira, Robson Francisco Carvalho, Luis Antonio Justulin
Frontiers in Molecular Biosciences, 2021
Exposure to bacteriophages t4 and m13 increases integrin gene expression and impairs migration of human pc-3 prostate cancer cells
Swapnil Ganesh Sanmukh, Nilton J. Santos, Caroline Nascimento Barquilha, Sérgio Alexandre Alcantara dos Santos, Bruno Oliveira Silva Duran, Flávia Karina Delella, Andrei Moroz, Luis Antonio Justulin, Hernandes F. Carvalho, Sérgio Luis Felisbino
Antibiotics, 2021
Transcriptomic landscape of male and female reproductive cancers: Similar pathways and molecular signatures predicting response to endocrine therapy
Ana CL. Camargo, Beatriz Remoli, Luiz MF. Portela, Mateus N. Fioretto, Luiz GA. Chuffa, Carlos S. Moreno, Luis A. Justulin
Molecular and Cellular Endocrinology, 2021
Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension
Thaoan Bruno Mariano, Anthony César de Souza Castilho, Ana Karenina Dias de Almeida Sabela, André Casanova de Oliveira, Sarah Santiloni Cury, Andreo Fernando Aguiar, Raisa de Jesus Dutra Dias, Antonio Carlos Cicogna, Katashi Okoshi, Luis Antonio Justulin Junior, Robson Francisco Carvalho, Francis Lopes Pacagnelli
Plos One, 2021
Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer
Nilton José Santos, Caroline Nascimento Barquilha, Isabela Correa Barbosa, Rodrigo Tavares Macedo, Flávio Oliveira Lima, Luis Antônio Justulin, Guilherme Oliveira Barbosa, Hernandes F. Carvalho, Sérgio Luis Felisbino
International Journal of Molecular Sciences, 2021
Maternal protein restriction changes structural and metabolic gene expression in the skeletal muscle of aging offspring rats
Jéssica S. Valente, Erika S. Perez, Bruna Tereza Thomazini Zanella, Tassiana Gutierrez de Paula, Sérgio Alexandre Alcântara dos Santos, et al.
Histology and Histopathology, 2021
The essential oil from Baccharis trimera (Less.) DC improves gastric ulcer healing in rats through modulation of VEGF and MMP-2 activity
Gabriela Bueno, Stefanni Liliane Chavez Rico, Larissa Lucena Périco, Rie Ohara, Vinicius Peixoto Rodrigues, Maycon Tavares Emílio-Silva, Renata Assunção, Lucia Regina Machado da Rocha, Domingos Sávio Nunes, Michele Aparecida Besten, Gustavo Heiden, Ana Carolina Lima Camargo, Luis Antonio Justulin, Clélia Akiko Hiruma-Lima
Journal of Ethnopharmacology, 2021
Increased oxidative stress and cancer biomarkers in the ventral prostate of older rats submitted to maternal malnutrition
Luiz MF. Portela, Sérgio AA. Santos, Flavia B. Constantino, Ana CL. Camargo, Ketlin T. Colombelli, Matheus N. Fioretto, Caroline N. Barquilha, Larissa L. Périco, Clélia A. Hiruma-Lima, Wellerson R. Scarano, Elena Zambrano, Luís A. Justulin
Molecular and Cellular Endocrinology, 2021
Protein feed stimulates the development of mandibular glands of honey bees (Apis mellifera)
Marcelo P Camilli, Daniel C B de Barros, Luis A Justulin, Marcos L P Tse, Ricardo de Oliveira Orsi
Journal of Apicultural Research, 2021
Mineral iron affects the development of mandibular gland in Apis mellifera
Daniel C. B. de Barros, Alex Junji Shinohara, Marcelo P. Camilli, Sérgio A. A. Santos, Luis A. Justulin, Ricardo de Oliveira Orsi
Journal of Apicultural Research, 2021
Maternal protein restriction impairs nutrition and ovarian histomorphometry without changing p38MAPK and PI3K-AKT-mTOR signaling in adult rat ovaries
Lucas Silva Côrtes, Henrique Spaulonci Silveira, Luiz Antonio Lupi, Talita de Mello Santos, Marilia Martins Cavariani, Raquel Fantin Domeniconi, Letícia Barbosa Gaiotte, Diego Augusto de Morais Oliveira, Luis Antonio Justulin, Luiz Gustavo de Almeida Chuffa
Life Sciences, 2021
A meta-analysis of microRNA networks regulated by melatonin in cancer: Portrait of potential candidates for breast cancer treatment
Luiz Gustavo de Almeida Chuffa, Robson Francisco Carvalho, Luis Antônio Justulin, Sarah Santiloni Cury, Fábio Rodrigues Ferreira Seiva, Bruna Victorasso Jardim‐Perassi, Debora Aparecida Pires de Campos Zuccari, Russel J. Reiter
Journal of Pineal Research, 2020
Panax ginseng metabolite (GIM-1) modulates the effects of monobutyl phthalate (MBP) on the GPR30/GPER1 canonical pathway in human Sertoli cells
André Teves A.G. de Freitas, Cristiane Figueiredo Pinho, Ariana Musa Aquino, Raquel Fantin Domeniconi, Luis Antonio Justulin, Wellerson Rodrigo Scarano
Reproductive Toxicology, 2020
Terminalia catappa L. infusion accelerates the healing process of gastric ischemia-reperfusion injury in rats
Rie Ohara, Larissa Lucena Périco, Vinicius Peixoto Rodrigues, Gabriela Bueno, Ana Caroline Zanatta, Lourdes Campaner dos Santos, Wagner Vilegas, Flavia Bessi Constatino, Luis Antonio Justulin, Clélia Akiko Hiruma-Lima
Journal of Ethnopharmacology, 2020
Highly effective fibrin biopolymer scaffold for stem cells upgrading bone regeneration
Camila Fernanda Zorzella Creste, Patrícia Rodrigues Orsi, Fernanda Cruz Landim-Alvarenga, Luis Antônio Justulin, Marjorie de Assis Golim, Benedito Barraviera, Rui Seabra Ferreira
Materials, 2020
Seasonal variation of flavonoid content in bee bread: Potential impact on hypopharyngeal gland development in Apis mellifera honey bees
Thaís de Souza Bovi, André Caeiro, Sérgio Alexandre Alcantara dos Santos, Rodrigo Zaluski, Alex Junji Shinohara, Giuseppina Pace Pereira Lima, Maria da Graça Ribeiro Campos, Luis Antonio Justulin Junior, Ricardo de Oliveira Orsi
Journal of Apicultural Research, 2020
Chapter 20: Nutrition and prostate cancer prevention
L. A. Justulin, S. A. A. dos Santos, D. C. Damasceno, W. R. Scarano, S. L. Felisbino
Food Chemistry Function and Analysis, 2020
Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer
Caroline N. Barquilha, Nilton J. Santos, Caio C. D. Monção, Isabela C. Barbosa, Flávio O. Lima, Luis A. Justulin, Nelma Pértega-Gomes, Sérgio L. Felisbino
Oxidative Medicine and Cellular Longevity, 2020
Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition
Sérgio Alexandre Alcantara Santos, Ana Carolina Lima Camargo, Flávia Bessi Constantino, Ketlin Thassiani Colombelli, Luiz Marcos Frediani Portela, Matheus Naia Fioretto, José Cavalcante Souza Vieira, Pedro Magalhães Padilha, Mateus Betta de Oliveira, Sergio Luis Felisbino, Robson Francisco Carvalho, Luis Antonio Justulin
Aging, 2020
“Prostate telocytes change their phenotype in response to castration or testosterone replacement”
Sérgio Luis Felisbino, Bruno Domingos Azevedo Sanches, Flávia Karina Delella, Wellerson Rodrigo Scarano, Fernanda Cristina Alcântara Dos Santos, Patrícia Simone Leite Vilamaior, Sebastião Roberto Taboga, Luis Antônio Justulin
Scientific Reports, 2019
Impact of gestational low protein diet and postnatal bisphenol A exposure on chemically induced mammary carcinogenesis in female offspring rats
Muriele B. Varuzza, Joyce R. Zapaterini, Ketlin T. Colombelli, Caroline N. Barquilha, Luis A. Justulin, Monica Muñoz‐de‐Toro, Laura Kass, Luis F. Barbisan
Environmental Toxicology, 2019
Arsenic exposure during prepuberty alters prostate maturation in pubescent rats
Ariana M. Aquino, Giovanna C. Salata, Cristiane F. Pinho, André T.A.G. de Freitas, Larissa L. Périco, Gláucia E.M. de Lion Siervo, Leonardo O. Mendes, Paloma Da Cunha De Medeiros, Luís A. Justulin, Glaura S.A. Fernandes, Juliana E. Perobelli, Wellerson R. Scarano
Reproductive Toxicology, 2019
Exposure to an Environmentally Relevant Phthalate Mixture during Prostate Development Induces MicroRNA Upregulation and Transcriptome Modulation in Rats
Wellerson R Scarano, Amina Bedrat, Luiz G Alonso-Costa, Ariana M Aquino, Bruno E A Fantinatti, Luis A Justulin, Luis F Barbisan, Paula P Freire, Jodi A Flaws, Bernardo Lemos
Toxicological Sciences, 2019
Raloxifene decreases cell viability and migratory potential in prostate cancer cells (LNCaP) with GPR30/GPER1 involvement
Giovanna Cassone Salata, Cristiane Figueiredo Pinho, André T A G de Freitas, Ariana Musa Aquino, Luis Antonio Justulin, Leonardo Oliveira Mendes, Bianca F Gonçalves, Flávia Karina Delella, Wellerson Rodrigo Scarano
Journal of Pharmacy and Pharmacology, 2019
Panax ginseng methabolit (GIM-1) prevents oxidative stress and apoptosis in human Sertoli cells exposed to Monobutyl-phthalate (MBP)
André Teves A.G. DE FREITAS, Cristiane Figueiredo PINHO, Ariana Musa de AQUINO, Ana Angélica H. FERNANDES, Raquel Fantin DOMENICONI, Luis Antonio JUSTULIN, Wellerson Rodrigo SCARANO
Reproductive Toxicology, 2019
Maternal low-protein diet impairs prostate growth in young rat offspring and induces prostate carcinogenesis with aging
Sergio A A Santos, Ana C Camargo, Flávia B Constantino, Ketlin T Colombelli, Fernanda Mani, Jaqueline C Rinaldi, Suelen Franco, Luiz M F Portela, Bruno O S Duran, Wellerson R Scarano, Barry T Hinton, Sergio L Felisbino, Luis A Justulin
Journals of Gerontology Series A Biological Sciences and Medical Sciences, 2019
Protective effect of resveratrol on urogenital sinus and prostate development in rats exposed in utero to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin)
Lívia Teresa Ribeiro Silveira, Talita de Mello Santos, Lucas Fredini Camora, Cristiane Figueiredo Pinho, Janete A. Anselmo-Franci, Raquel Fantin Domeniconi, Luis Antonio Justulin, Luis Fernando Barbisan, Wellerson Rodrigo Scarano
Reproductive Toxicology, 2019
Fibrin biopolymer as scaffold candidate to treat bone defects in rats
Claudia Vilalva Cassaro, Luis Antonio Justulin Jr., Patrícia Rodrigues de Lima, Marjorie de Assis Golim, Natália Perussi Biscola, Mateus Vidigal de Castro, Alexandre Leite Rodrigues de Oliveira, Danuta Pulz Doiche, Elenize Jamas Pereira, Rui Seabra Ferreira Jr., Benedito Barraviera
Journal of Venomous Animals and Toxins Including Tropical Diseases, 2019
Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats
Larissa Lucena Périco, Vinícius Peixoto Rodrigues, Rie Ohara, Gabriela Bueno, Vânia Vasti Alfieri Nunes, Raquel de Cássia dos Santos, Ana Carolina Lima Camargo, Luis Antônio Justulin Júnior, Sérgio Faloni de Andrade, Viviane Miranda Bispo Steimbach, Luísa Mota da Silva, Lúcia Regina Machado da Rocha, Wagner Vilegas, Catarina dos Santos, Clélia Akiko Hiruma-Lima
World Journal of Gastroenterology, 2018
Maternal protein malnutrition: Effects on prostate development and adult disease
J. C. Rinaldi, S. A. A. Santos, K. T. Colombelli, L. Birch, G. S. Prins, L. A. Justulin, S. L. Felisbino
Journal of Developmental Origins of Health and Disease, 2018
Evaluation of collagen in dermal wounds of rabbits treated with different sources of platelet-rich plasma
E. Ferraciolli, C.B. Laposy, M.R. Nogueira, L.A. Justulin Júnior, J.C. Camargo Filho, V. Moreira, M.E. Marques, G. Nai, G. Ozaki
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, 2018
Combinatorial Effect of Abiraterone Acetate and NVP-BEZ235 on Prostate Tumor Progression in Rats
Bianca Facchim Gonçalves, Silvana Gisele Pegorin de Campos, Wagner José Fávaro, Joyce Zalotti Brandt, Cristiane Figueiredo Pinho, Luis Antônio Justulin, Sebastião Roberto Taboga, Wellerson Rodrigo Scarano
Hormones and Cancer, 2018
Influence of postnatal prolactin modulation on the development and maturation of ventral prostate in young rats
Ana C. L. Camargo, Flávia B. Constantino, Sérgio A. A. Santos, Ketlin T. Colombelli, Maeli Dal-Pai-Silva, Sérgio L. Felisbino, Luis A. Justulin
Reproduction Fertility and Development, 2018
Hyperglycemic condition during puberty increases collagen fibers deposition in the prostatic stroma and reduces MMP-2 activity
Sérgio Alexandre Alcantara dos Santos, Elaine Manoela Porto Amorim, Larissa Mayume Ribeiro, Jaqueline Carvalho Rinaldi, Flávia Karina Delella, Luis Antonio Justulin, Sérgio Luis Felisbino
Biochemical and Biophysical Research Communications, 2017
Field-relevant doses of the systemic insecticide fipronil and fungicide pyraclostrobin impair mandibular and hypopharyngeal glands in nurse honeybees (Apis mellifera)
Rodrigo Zaluski, Luis Antonio Justulin, Ricardo de Oliveira Orsi
Scientific Reports, 2017
Apitoxin harvest impairs hypopharyngeal gland structure in Apis mellifera honey bees
Thaís S. Bovi, Paula Onari, Sérgio A. A. Santos, Luis A. Justulin, Ricardo O. Orsi
Apidologie, 2017
The prostate response to prolactin modulation in adult castrated rats subjected to testosterone replacement
Flávia B. Constantino, Ana C. L. Camargo, Sérgio A. A. Santos, Ketlin T. Colombelli, Laura F. Martin, Marcia G. Silva, Sérgio L. Felisbino, Luis A. Justulin
Journal of Molecular Histology, 2017
Impact of maternal and postnatal zinc dietary status on the prostate of pubescent and adult rats
Lucas F. Camora, Ana Priscila G. Silva, Sérgio A.A. Santos, Luis A. Justulin, Juliana E. Perobelli, Luis Fernando Barbisan, Wellerson R. Scarano
Cell Biology International, 2017
A unique heterologous fibrin sealant (HFS) as a candidate biological scaffold for mesenchymal stem cells in osteoporotic rats
Patrícia Rodrigues Orsi, Fernanda Cruz Landim-Alvarenga, Luis Antônio Justulin, Ramon Kaneno, Marjorie de Assis Golim, Daniela Carvalho dos Santos, Camila Fernanda Zorzella Creste, Eunice Oba, Leandro Maia, Benedito Barraviera, Rui Seabra Ferreira
Stem Cell Research and Therapy, 2017
Impairment of microvascular angiogenesis is associated with delay in prostatic development in rat offspring of maternal protein malnutrition
Ketlin T. Colombelli, Sérgio A.A. Santos, Ana C.L. Camargo, Flávia B. Constantino, Caroline N. Barquilha, Jaqueline C. Rinaldi, Sérgio L. Felisbino, Luis A. Justulin
General and Comparative Endocrinology, 2017
Streptozotocin-Induced Maternal Hyperglycemia Increases the Expression of Antioxidant Enzymes and Mast Cell Number in Offspring Rat Ventral Prostate
Ana C. L. Camargo, Sérgio A. A. Dos Santos, Jaqueline C. Rinaldi, Flavia B. Constantino, Ketlin T. Colombelli, Wellerson R. Scarano, Sérgio L. Felisbino, Luis A. Justulin
Anatomical Record, 2017
Collagen quantification in rabbit dermal wounds treated with heterologous platelet-rich plasma gel
Maria Elisa Marin Marques, Cecília Braga Laposy, Mariana Lucas Dos Santos Silva, Maria Rosa Santos Breda, Mayara Mascaro Matsumoto, Luis Antonio Justulin Junior, Gisele Alborghetti Nai, Guilherme Akio Tamura Ozaki, José Carlos Camargo Filho, Rosa Maria Barilli Nogueira
Semina Ciencias Agrarias, 2017
Effects of intra-articular injection of mesenchymal stem cells associated with platelet-rich plasma in a rabbit model of osteoarthritis
L.C. Hermeto, R. DeRossi, R.J. Oliveira, J.R. Pesarini, A.C.M.B. Antoniolli-Silva, P.H.A. Jardim, Á.E. Santana, E. Deffune, J.C. Rinaldi, L.A. Justulin
Genetics and Molecular Research, 2016
Comparison between two different experimental model of osteoarthritis in rabbits. Intra-articular collagenase injection and anterior cruciate ligament transection
Larissa Correa Hermeto, Rafael De Rossi, Paulo Henrique de Affonseca Jardim, Aureo Evangelista Santana, Jaqueline de Carvalho Rinaldi, Luis Antonio Justulin
Acta Cirurgica Brasileira, 2016
Long-term effects of perinatal exposure to low doses of cadmium on the prostate of adult male rats
Viviane P. Santana, Évila S. Salles, Deborah E. Correa, Bianca F. Gonçalves, Silvana G. Campos, Luiz A. Justulin, Antonio F. Godinho, Wellerson R. Scarano
International Journal of Experimental Pathology, 2016
Ethanol modulates the synthesis and catabolism of retinoic acid in the rat prostate
Beatriz Aparecida Fioruci-Fontanelli, Luiz Gustavo A. Chuffa, Leonardo O. Mendes, Patricia Fernanda F. Pinheiro, Luis Antônio Justulin, Sérgio Luis Felisbino, Francisco Eduardo Martinez
Reproductive Toxicology, 2015
Cadmium exposure inhibits MMP2 and MMP9 activities in the prostate and testis
Livia M. Lacorte, Jaqueline C. Rinaldi, Luis A. Justulin, Flávia K. Delella, Andrei Moroz, Sérgio L. Felisbino
Biochemical and Biophysical Research Communications, 2015
Impact of gestational diabetes and lactational insulin replacement on structure and secretory function of offspring rat ventral prostate
Sérgio A.A. Santos, Jaqueline C. Rinaldi, Amanda E. Martins, Ana C.L. Camargo, Carina Leonelli, Flávia K. Delella, Sérgio L. Felisbino, Luis A. Justulin
General and Comparative Endocrinology, 2014
Protective effect of γ-tocopherol-enriched diet on N-methyl-N-nitrosourea-induced epithelial dysplasia in rat ventral prostate
Lucas D. Sanches, Sergio A. A. Santos, Jaqueline R. Carvalho, Gabriela D. M. Jeronimo, Wagner J. Favaro, Maria D. G. Reis, Sérgio L. Felisbino, Luis A. Justulin
International Journal of Experimental Pathology, 2013
Implications of intrauterine protein malnutrition on prostate growth, maturation and aging
Jaqueline C. Rinaldi, Luis A. Justulin, Livia M. Lacorte, Carolina Sarobo, Patricia A. Boer, Wellerson R. Scarano, Sergio L. Felisbino
Life Sciences, 2013
Structural and ultrastructural evidence for telocytes in prostate stroma
Lara S. Corradi, Mariana M. Jesus, Ricardo A. Fochi, Patricia S. L. Vilamaior, Luis A. Justulin‐, Rejane M. Góes, Sérgio L. Felisbino, Sebastião R. Taboga
Journal of Cellular and Molecular Medicine, 2013
Mechanism and effect of esculetin in an experimental animal model of inflammatory bowel disease
A. Witaicenis, A.C. Luchini, C.A. Hiruma-Lima, S.L. Felisbino, L.A. Justulin, N. Garrido-Mesa, P. Utrilla, J. Gálvez, L.C. Di Stasi
European Journal of Inflammation, 2013
MMP-2 and TIMP-2 in the prostates of male and female mongolian gerbils: Effects of hormonal manipulation
Histology and Histopathology, 2011
Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity
André F. Nascimento, Renata A.M. Luvizotto, André S. Leopoldo, Ana P. Lima-Leopoldo, Fábio R. Seiva, Luís A. Justulin, Maeli Dal Pai Silva, Katashi Okoshi, Xiang-Dong Wang, Antonio C. Cicogna
Life Sciences, 2011
Exposure to Mycobacterium avium Decreases the Protective Effect of the DNA Vaccine pVAXhsp65 Against Mycobacterium tuberculosis-Induced Inflammation of the Pulmonary Parenchyma
D. R. Martins, A. C. Pelizon, S. F. G. Zorzella‐Pezavento, J. Seger, R. R. Santos Junior, D. M. Fonseca, L. A. Justulin Jr, C. L. Silva, A. Sartori
Scandinavian Journal of Immunology, 2011
Lobe variation effects of experimental diabetes and insulin replacement on rat prostate
Elaine Manoela Porto, Sérgio Alexandre De Alcântara Dos Santos, Larissa Mayumi Ribeiro, Lívia Maria Lacorte, Jaqueline Carvalho Rinaldi, Luis Antonio Justulin, Sérgio Luís Felisbino
Microscopy Research and Technique, 2011
Microscopical evaluation of extracellular matrix and its relation to the palatopharyngeal muscle in obstructive sleep apnea
Fernando D. Molina, Fernanda C.A. Santos, Luis R. Falleiros, Eny M. Goloni‐Bertollo, Sérgio L. Felisbino, Luis A. Justulin, José V. Maniglia, Sebastião R. Taboga
Microscopy Research and Technique, 2011
Early changes induced by short-term low-dose cadmium exposure in rat ventral and dorsolateral prostates
Lívia M. Lacorte, Flavia K. Delella, Elaine M. Porto Amorim, Luis A. Justulin, Antonio F. Godinho, Alaor A. Almeida, Patrícia F. Felipe Pinheiro, Renée L. Amorim, Sérgio L. Felisbino
Microscopy Research and Technique, 2011
MMP-2 and MMP-9 localization and activity in the female prostate during estrous cycle
Fernanda C.A. Santos, Sabrina S. Rochel-Maia, Ricardo A. Fochi, Luis A. Justulin, Sérgio A.A. Santos, Patrícia S.L. Vilamaior, Sérgio L. Felisbino, Rejane M. Góes, Sebastião R. Taboga
General and Comparative Endocrinology, 2011
Matrix metalloproteinase (MMP)-2 and MMP-9 activity and localization during ventral prostate atrophy and regrowth
L. A. Justulin Jr, H. H. M. Della‐Coleta, S. R. Taboga, S. L. Felisbino
International Journal of Andrology, 2010
Combined effect of the finasteride and doxazosin on rat ventral prostate morphology and physiology
Luis A. Justulin Jr, Carolina Acquaro, Robson F. Carvalho, Maeli Dal Pai Silva, Sérgio L. Felisbino
International Journal of Andrology, 2010
Finasteride treatment alters MMP-2 and -9 gene expression and activity in the rat ventral prostate
Flávia K. Delella, Luis A. Justulin Jr, Sérgio L. Felisbino
International Journal of Andrology, 2010
Neonatal BCG immunization followed by dnahsp65 boosters: Highly immunogenic but not protective against tuberculosis-a paradoxical effect of the vector?
A. C. Pelizon, D. R. Martins, S. F. G. Zorzella-Pezavento, J. Seger, L. A. Justulin Jr, D. M. da Fonseca, R. R. Santos Jr, A. P. Masson, C. L. Silva, A. Sartori
Scandinavian Journal of Immunology, 2010
Tissue vitamin A insufficiency results in adverse ventricular remodeling after experimental myocardial infarction
Marcos F. Minicucci, Paula S. Azevedo, Silvio A. Oliveira Jr., Paula F. Martinez, Fernanda Chiuso-Minicucci, Bertha F. Polegato, Luis A. Justulin Jr., Luiz S. Matsubara, Beatriz B. Matsubara, Sergio A.R. Paiva, Leonardo A.M. Zornoff
Cellular Physiology and Biochemistry, 2010
Ventricular remodeling induced by tissue vitamin A deficiency in rats
Paula S. Azevedo, Marcos F. Minicucci, Fernanda Chiuso-Minicucci, Luis A. Justulin Jr, Luiz S. Matsubara, Beatriz B. Matsubara, Ethel Novelli, Fabio Seiva, Giovanna Ebaid, Alvaro O. Campana, Leonardo A.M. Zornoff, Sergio A.R. Paiva
Cellular Physiology and Biochemistry, 2010
Calcaneal tendon regions exhibit different MMP-2 activation after vertical jumping and treadmill running
Olga Cristina De Mello Malheiro, Camila Tateishi Giacomini, Luis Antonio Justulin, Flávia Karina Delella, Maeli Dal‐Pai‐Silva, Sérgio Luis Felisbino
Anatomical Record, 2009
Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: Proliferative and inflammatory disorders and a possible role of androgens
Wellerson Rodrigo Scarano, Fabíola Choqueta de Toledo, Marina Trevizan Guerra, Silvana Gisele Pegorin de Campos, Luís Antonio Justulin Júnior, Sérgio Luis Felisbino, Janete A. Anselmo-Franci, Sebastião Roberto Taboga, Wilma De Grava Kempinas
Toxicology, 2009
Effect of mangiferin on the development of periodontal disease: Involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling
Roney Rick Carvalho, Claudia Helena Pellizzon, Luis Justulin, Sergio Luis Felisbino, Wagner Vilegas, Fernanda Bruni, Mônica Lopes-Ferreira, Clélia Akiko Hiruma-Lima
Chemico Biological Interactions, 2009
Differential MMP-2 and MMP-9 activity and collagen distribution in skeletal muscle from pacu (Piaractus mesopotamicus) during juvenile and adult growth phases
Aline Cristina Michelin, Luis Antonio Justulin, Flávia Karina Delella, Carlos Roberto Padovani, Sérgio Luis Felisbino, Maeli Dal‐Pai‐Silva
Anatomical Record, 2009
Metalloproteinases 2 and -9 activity during promotion and progression stages of rat liver carcinogenesis
Kelly Silva Furtado, Paulo Wagner Pires, Luis Antonio Justulin, Maria Aparecida Marchesan Rodrigues, Sergio Luis Felisbino, Luis Fernando Barbisan
Journal of Molecular Histology, 2009
Evaluation of matrix metalloproteinases -2 and -9 in cats under bone demineralization secondary to induced thyrotoxicosis
F.S. Costa, M.J.L. Cardoso, L.M.R. Muniz, L.C. Vulcano, L.A. Justulin Júnior, S.L. Felisbino, S. Martins Filho
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, 2008
Immunolocalization of aquaporins 1, 2 and 7 in rete testis, efferent ducts, epididymis and vas deferens of adult dog
Raquel Fantin Domeniconi, Antonio Marcos Orsi, Luis Antonio Justulin, Célia Cristina Leme Beu, Sérgio Luis Felisbino
Cell and Tissue Research, 2008
Doxazosin reduces cell proliferation and increases collagen fibers in rat prostatic lobes
Luis A. Justulin, Flavia K. Delella, Sérgio L. Felisbino
Cell and Tissue Research, 2008
Aquaporin 9 (AQP9) localization in the adult dog testis excurrent ducts by immunohistochemistry
Raquel Fantin Domeniconi, Antonio Marcos Orsi, Luis Antonio Justulin, Célia Cristina Leme Beu, Sérgio Luis Felisbino
Anatomical Record, 2007
Epithelial-stromal transition of MMP-7 immunolocalization in the rat ventral prostate following bilateral orchiectomy
Sergio L. Felisbino, Luis A. Justulin Junior, Hernandes F. Carvalho, Sebastião R. Taboga
Cell Biology International, 2007
Tissue inhibitor of metalloproteinase-2 (TIMP-2) location in the ventral, lateral, dorsal and anterior lobes of rat prostate by immunohistochemistry
Flávia K. Delella, Luis A. Justulin, Sérgio L. Felisbino
Cell Biology International, 2007
Heart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle
Robson Francisco Carvalho, Rafael Dariolli, Luis Antonio Justulin Junior, Mário Mateus Sugizaki, Marina Politi Okoshi, Antonio Carlos Cicogna, Sérgio Luis Felisbino, Maeli Dal Pai‐Silva
International Journal of Experimental Pathology, 2006
Differential proliferative response of the ventral prostate and seminal vesicle to testosterone replacement
Luis A. Justulin, Rodrigo P. Ureshino, Michelle Zanoni, Sergio L. Felisbino
Cell Biology International, 2006

Luis Antonio Justulin Jr

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