Soo Chan Lee

Scopus Publications

Engineering polyphosphate-accumulating probiotics for therapeutic applications in chronic kidney disease
Jeong Pin Ahn, Sung Jin Moon, Migi Lee, Min Young Kwon, Ju-Yeon Pyo, Soo Chan Lee, Hyo Jin Kim
Food Bioscience, 2025
Heterotrimeric G-gamma 1 (Gpg1) participates with G-beta 1 (Gpb1) in the induction of hyphal growth and virulence via the PKA pathway in Mucor lusitanicus
J. Alberto Patiño-Medina, David Vargas-Tejeda, Nancy Y. Reyes-Mares, Viridiana Alejandre-Castañeda, Cesar J. Torres-Cortes, Carlos Pérez-Arques, Leon F. Ruiz-Herrera, Joel Ramírez-Emiliano, Sandeep Vellanki, Marco I. Valle-Maldonado, Karla Viridiana Castro-Cerritos, Martha I. Ramirez-Diaz, Soo Chan Lee, Victoriano Garre, Víctor Meza-Carmen
Fungal Genetics and Biology, 2025
Weissella sp. SNUL2 as potential probiotics with broad-spectrum antimicrobial activities
Jae Won Han, Nari Lee, Hea Joon Kim, Sung Jin Moon, Soo Chan Lee, Hyo Jin Kim
Heliyon, 2024
Probiotics have been applied to a wide range of bacteria, causing gastrointestinal and vaginal infections. However, probiotics generally possess limited antimicrobial spectra and are primarily utilized as dietary supplements. Recognizing the need for more versatile probiotics, this study focuses on isolating and characterizing strains suitable for antibiotic replacement. Among these strains, Weissella sp. SNUL2, derived from a traditional fermented food in Korea (i.e., Sikhae), emerged as a promising candidate. The correlation between optical density at 600 nm and colony-forming units was verified and applied in subsequent experiments. To assess the therapeutic potential of probiotics, antibacterial tests were conducted using a microplate reader to evaluate the inhibition of 60 bacterial strains (including common foodborne pathogens) induced by Weissella sp. SNUL2 cell-free supernatant (CFS). The results confirmed its broad-spectrum antibacterial properties compared to previously known probiotics. Furthermore, enzymatic treatment with proteinases (trypsin and pepsin) and a time-kill assay were conducted to elucidate the nature of the antibacterial substance in Weissella sp. SNUL2 CFS. Through sequential chromatography involving gel filtration and ion-exchange chromatography, specific fractions with enhanced antibacterial properties were identified. LC-MS/MS analysis of the secretome fraction revealed the presence of various proteins from the C39 family, peptidoglycan endopeptidases, and N-acetylmuramoyl-l-alanine amidase domain-containing protein precursors. Hence, the combined action of these proteins may contribute to Weissella sp. SNUL2's broad antimicrobial activity.
The players within the intestinal microbiome (bacteria, fungi, parasites, and viruses)
Jintong Liu, Marie Fogarty, Soo Chan Lee, Michael Dougherty, Renay Ngobeni-Nyambi, Yi Ge, Ian M. Carroll
Clinical Understanding of the Human Gut Microbiome, 2024
Transcription Factors Tec1 and Tec2 Play Key Roles in the Hyphal Growth and Virulence of Mucor lusitanicus Through Increased Mitochondrial Oxidative Metabolism
Viridiana Alejandre-Castañeda, J. Alberto Patiño-Medina, Marco I. Valle-Maldonado, Alexis García, Rafael Ortiz-Alvarado, León F. Ruíz-Herrera, Karla Viridiana Castro-Cerritos, Joel Ramírez-Emiliano, Martha I. Ramírez-Díaz, Victoriano Garre, Soo Chan Lee, Víctor Meza-Carmen
Journal of Microbiology, 2023
Mucormycosis is a lethal and difficult-to-treat fungal infection caused by fungi of the order Mucorales. Mucor lusitanicus, a member of Mucorales, is commonly used as a model to understand disease pathogenesis. However, transcriptional control of hyphal growth and virulence in Mucorales is poorly understood. This study aimed to investigate the role of Tec proteins, which belong to the TEA/ATTS transcription factor family, in the hyphal development and virulence of M. lusitanicus. Unlike in the genome of Ascomycetes and Basidiomycetes, which have a single Tec homologue, in the genome of Mucorales, two Tec homologues, Tec1 and Tec2, were found, except in that of Phycomyces blakesleeanus, with only one Tec homologue. tec1 and tec2 overexpression in M. lusitanicus increased mycelial growth, mitochondrial content and activity, expression of the rhizoferrin synthetase-encoding gene rfs, and virulence in nematodes and wax moth larvae but decreased cAMP levels and protein kinase A (PKA) activity. Furthermore, tec1- and tec2-overexpressing strains required adequate mitochondrial metabolism to promote the virulent phenotype. The heterotrimeric G beta subunit 1-encoding gene deletant strain (Δgpb1) increased cAMP-PKA activity, downregulation of both tec genes, decreased both virulence and hyphal development, but tec1 and tec2 overexpression restored these defects. Overexpression of allele-mutated variants of Tec1(S332A) and Tec2(S168A) in the putative phosphorylation sites for PKA increased both virulence and hyphal growth of Δgpb1. These findings suggest that Tec homologues promote mycelial development and virulence by enhancing mitochondrial metabolism and rhizoferrin accumulation, providing new information for the rational control of the virulent phenotype of M. lusitanicus.
Serine/Threonine Phosphatase Calcineurin Orchestrates the Intrinsic Resistance to Micafungin in the Human-Pathogenic Fungus Mucor circinelloides
Alexis Garcia, Eun Young Huh, Soo Chan Lee
Antimicrobial Agents and Chemotherapy, 2023
Procedures such as solid-organ transplants and cancer treatments can leave many patients in an immunocompromised state. This leads to their increased susceptibility to opportunistic diseases such as fungal infections.
Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi, and
Intestinal Research, 2023
Background/Aims: The fecal microbiota of Korean patients with inflammatory bowel disease (IBD) was investigated with respect to disease phenotypes and taxonomic biomarkers for diagnosis and prognosis of IBD.Methods: Fecal samples from 70 ulcerative colitis (UC) patients, 39 Crohn’s disease (CD) patients, and 100 healthy control individuals (HC) were collected. The fecal samples were amplified via polymerase chain reaction and sequenced using Illumina MiSeq. The relationships between fecal bacteria and clinical phenotypes were analyzed using the EzBioCloud database and 16S microbiome pipeline.Results: The alpha-diversity of fecal bacteria was significantly lower in UC and CD (P<0.05) compared to that in HC. Bacterial community compositions in UC and CD were significantly different from that of HC according to Bray-Curtis dissimilarities, and there was also a difference between community composition in UC and CD (P=0.01). In UC, alpha-diversity was further decreased when the disease was more severe and the extent of disease was greater, and community composition significantly differed depending on the extent of the disease. We identified 9 biomarkers of severity and 6 biomarkers of the extent of UC. We also identified 5 biomarkers of active disease and 3 biomarkers of ileocolonic involvement in CD. Lachnospiraceae and Ruminococcus gnavus were biomarkers for better prognosis in CD.Conclusions: The fecal microbiota profiles of IBD patients were different from those of HC, and several bacterial taxa may be used as biomarkers to determine disease phenotypes and prognosis. These data may also help discover new therapeutic targets for IBD.
Current treatments against mucormycosis and future directions
Courtney Smith, Soo Chan Lee
Plos Pathogens, 2022
Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of fungi belonging to the order Mucorales. These molds exist throughout the environment and generally do not cause serious problems in humans. Mucormycosis mainly affects individuals who are immunocompromised. The clinical manifestations of mucormycosis are wide-ranging; they include sinusitis (pansinusitis, rhino-orbital, or rhino-cerebral) as well as cutaneous, gastrointestinal, pulmonary, and disseminate infections. Many uncertainties remain regarding how to control these infections despite the recent addition of triazoles to the antifungal arsenal for treating this infection. Currently, lipid formulations of amphotericin B have become the standard treatment for mucormycosis due to their efficiency. Moreover, a growing body of data supports the need for surgical excision of infected and/or necrosed tissue whenever practical. In this mini review, the current status of treatment options for mucormycosis and recent studies of novel therapeutic options will be presented.
Identification of Mucormycosis by Fluorescence In Situ Hybridization Targeting Ribosomal RNA in Tissue Samples
Jill Jasmine Dalimot, Ilka Mc Cormick Smith, Jasmin Gerkrath, Sylvia Hartmann, Oliver A. Cornely, Soo Chan Lee, Joseph Heitman, Volker Rickerts
Journal of Fungi, 2022
Mucormycosis is an invasive fungal infection associated with high mortality, partly due to delayed diagnosis and inadequate empiric therapy. As fungal cultures often fail to grow Mucorales, identification of respective hyphae in tissue is frequently needed for diagnosis but may be challenging. We studied fluorescence in situ hybridization (FISH) targeting specific regions of the fungal ribosomal RNA (rRNA) of Mucorales to improve diagnosis of mucormycosis from tissue samples. We generated a probe combination specifically targeting Mucorales. Probe specificity was verified in silico and using cultivated fungi. Mucorales hyphae in tissue of a mouse model demonstrated a bright cytoplasmatic hybridization signal. In tissue samples of patients with mucormycosis, a positive signal was seen in 7 of 12 (58.3%) samples. However, autofluorescence in 3 of 7 (42.9%) samples impaired the diagnostic yield. Subsequent experiments suggested that availability of nutrients and antifungal therapy may impact on the FISH signal obtained with Mucorales hyphae. Diagnosis of mucormycosis from tissue might be improved by rRNA FISH in a limited number of cases only. FISH signals may reflect different physiological states of fungi in tissue. Further studies are needed to define the value of FISH to diagnose mucormycosis from other clinical samples.
Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens
Sandeep Vellanki, Alexis E. Garcia, Soo Chan Lee
Frontiers in Molecular Biosciences, 2020
Over the past few decades advances in modern medicine have resulted in a global increase in the prevalence of fungal infections. Particularly people undergoing organ transplants or cancer treatments with a compromised immune system are at an elevated risk for lethal fungal infections such as invasive candidiasis, aspergillosis, cryptococcosis, etc. The emergence of drug resistance in fungal pathogens poses a serious threat to mankind and it is critical to identify new targets for the development of antifungals. Calcineurin and TOR proteins are conserved across eukaryotes including pathogenic fungi. Two small molecules FK506 and rapamycin bind to FKBP12 immunophilin and the resulting complexes (FK506-FKBP12 and rapamycin-FKBP12) target calcineurin and TOR, respectively in both humans and fungi. However, due to their immunosuppressive nature these drugs in the current form cannot be used as an antifungal. To overcome this, it is important to identify key differences between human and fungal FKBP12, calcineurin, and TOR proteins which will facilitate the development of new small molecules with higher affinity toward fungal components. The current review highlights FK506/rapamycin-FKBP12 interactions with calcineurin/TOR kinase in human and fungi, and development of non-immunosuppressive analogs of FK506, rapamycin, and novel small molecules in inhibition of fungal calcineurin and TOR kinase.
The heterotrimeric G-protein beta subunit Gpb1 controls hyphal growth under low oxygen conditions through the protein kinase A pathway and is essential for virulence in the fungus Mucor circinelloides
Marco Iván Valle‐Maldonado, José Alberto Patiño‐Medina, Carlos Pérez‐Arques, Nancy Yadira Reyes‐Mares, Irvin Eduardo Jácome‐Galarza, Rafael Ortíz‐Alvarado, Sandeep Vellanki, Martha Isela Ramírez‐Díaz, Soo Chan Lee, Victoriano Garre, Víctor Meza‐Carmen
Cellular Microbiology, 2020
Increased accumulation of medium-chain fatty acids by dynamic degradation of long-chain fatty acids in mucor circinelloides
Syed Ammar Hussain, Alexis Garcia, Md. Ahsanul Kabir Khan, Shaista Nosheen, Yao Zhang, Mattheos A. G. Koffas, Victoriano Garre, Soo Chan Lee, Yuanda Song
Genes, 2020
mSphere of influence: The mycobiota in human health and disease
Soo Chan Lee
Msphere, 2020
A novel resistance pathway for calcineurin inhibitors in the human-pathogenic mucorales mucor circinelloides
Sandeep Vellanki, R. Blake Billmyre, Alejandra Lorenzen, Micaela Campbell, Broderick Turner, Eun Young Huh, Joseph Heitman, Soo Chan Lee
Mbio, 2020
Tornadic shear stress induces a transient, calcineurindependent hypervirulent phenotype in mucorales molds
Sebastian Wurster, Alexander M. Tatara, Nathaniel D. Albert, Ashraf S. Ibrahim, Joseph Heitman, Soo Chan Lee, Amol C. Shetty, Carrie McCracken, Karen T. Graf, Antonios G. Mikos, Vincent M. Bruno, Dimitrios P. Kontoyiannis
Mbio, 2020
Heterotrimeric G-alpha subunits Gpa11 and Gpa12 define a transduction pathway that control spore size and virulence in Mucor circinelloides
J. Alberto Patiño-Medina, Nancy Y. Reyes-Mares, Marco I. Valle-Maldonado, Irvin E. Jácome-Galarza, Carlos Pérez-Arques, Rosa E. Nuñez-Anita, Jesús Campos-García, Verónica Anaya-Martínez, Rafael Ortiz-Alvarado, Martha I. Ramírez-Díaz, Soo Chan Lee, Victoriano Garre, Víctor Meza-Carmen
Plos One, 2019
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach
Nature Communications, 2019
Epigenetic mechanisms of drug resistance in fungi
Zanetta Chang, V. Yadav, Soo Chan Lee, J. Heitman
Fungal Genetics and Biology, 2019
Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens
Hee-Soo Park, Soo Chan Lee, M. Cárdenas, J. Heitman
Cell Host and Microbe, 2019
Maternal exercise before and during pregnancy alleviates metabolic dysfunction associated with high-fat diet in pregnant mice, without significant changes in gut microbiota
Eunhee Chung, Katherine A. Grue, Gurvinder Kaur, Brian Mallory, Christian R. Serrano, Sarah L. Ullevig, Kameswara Rao Kottapalli, Soo Chan Lee, Jannette M. Dufour, Chwan-Li Shen, Masataka Umeda
Nutrition Research, 2019
Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model
Katherine D. Mueller, Hao Zhang, Christian R. Serrano, R. Blake Billmyre, Eun Young Huh, Philipp Wiemann, Nancy P. Keller, Yufeng Wang, Joseph Heitman, Soo Chan Lee
Journal of Microbiology, 2019
CRISPR-Cas9 induces point mutation in the mucormycosis fungus Rhizopus delemar
Gillian O. Bruni, Keili Zhong, Soo Chan Lee, Ping Wang
Fungal Genetics and Biology, 2019
Candida albicans morphology-dependent host fgf-2 response as a potential therapeutic target
S. Vellanki, E. Huh, S. Saville, Soo Chan Lee
Journal of Fungi, 2019
Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides
Zanetta Chang, R. Blake Billmyre, Soo Chan Lee, Joseph Heitman
Plos Genetics, 2019
Rad53-and Chk1-dependent DNA damage response pathways cooperatively promote fungal pathogenesis and modulate antifungal drug susceptibility
Kwang-Woo Jung, Yeonseon Lee, Eun Young Huh, Soo Chan Lee, Sangyong Lim, Yong-Sun Bahn
Mbio, 2019
Nanoemulsion as an effective treatment against human-pathogenic fungi
Alexis Garcia, Yong Yi Fan, Sandeep Vellanki, Eun Young Huh, DiFernando Vanegas, Su He Wang, Soo Chan Lee
Msphere, 2019
Genetic Tools for Investigating Mucorales Fungal Pathogenesis
Alexis Garcia, S. Vellanki, Soo Chan Lee
Current Clinical Microbiology Reports, 2018
An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease
Liuyang Wang, Kelly J. Pittman, Jeffrey R. Barker, Raul E. Salinas, Ian B. Stanaway, Graham D. Williams, Robert J. Carroll, Tom Balmat, Andy Ingham, Anusha M. Gopalakrishnan, Kyle D. Gibbs, Alejandro L. Antonia, Joseph Heitman, Soo Chan Lee, Gail P. Jarvik, Joshua C. Denny, Stacy M. Horner, Mark R. DeLong, Raphael H. Valdivia, David R. Crosslin, Dennis C. Ko
Cell Host and Microbe, 2018
Mucor circinelloides: Growth, Maintenance, and Genetic Manipulation
S. Vellanki, M. Navarro-Mendoza, Alexis Garcia, L. Murcia, C. Pérez-Arques, V. Garre, F. Nicolás, Soo Chan Lee
Current Protocols in Microbiology, 2018
Outbreak of invasive wound mucormycosis in a burn unit due to multiple strains of Mucor circinelloides f. circinelloides resolved by whole-genome sequencing
D. García-Hermoso, A. Criscuolo, Soo Chan Lee, M. Legrand, M. Chaouat, B. Denis, M. Lafaurie, M. Rouveau, C. Soler, J. Schaal, M. Mimoun, A. Mebazaa, J. Heitman, F. Dromer, S. Brisse, S. Bretagne, A. Alanio
Mbio, 2018
Erratum for Ianiri et al., "FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia"
Giuseppe Ianiri, Shelly Applen Clancey, Soo Chan Lee, Joseph Heitman
Mbio, 2017
Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi
Soo Chan Lee, J. Heitman
Fungal Genetics and Biology, 2017
Fungal sex: The mucoromycota
Soo Chan Lee, Alexander Idnurm
Fungal Kingdom, 2017
FKBP12-dependent inhibition of calcineurin mediates immunosuppressive antifungal drug action in malassezia
G. Ianiri, Shelly Applen Clancey, Soo Chan Lee, J. Heitman
Mbio, 2017
Construction of a recyclable genetic marker and serial gene deletions in the human pathogenic mucorales Mucor circinelloides
Alexis Garcia, Gloria Adedoyin, J. Heitman, Soo Chan Lee
G3 Genes Genomes Genetics, 2017
A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides
S. Calo, F. Nicolás, Soo Chan Lee, Ana Vila, Maria Cervantes, S. Torres-Martínez, R. Ruiz-Vazquez, M. Cárdenas, J. Heitman
Plos Genetics, 2017
Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach
P. Juvvadi, Soo Chan Lee, J. Heitman, W. Steinbach
Virulence, 2017
Fungal sex: The mucoromycota
Soo Chan Lee, A. Idnurm
Microbiology Spectrum, 2017
Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis
Elizabeth J. Polvi, A. Averette, Soo Chan Lee, Taeyup Kim, Y. Bahn, Amanda O. Veri, Nicole Robbins, J. Heitman, L. Cowen
Plos Genetics, 2016
Dual action antifungal small molecule modulates multidrug efflux and TOR signaling
Tanvi Shekhar-Guturja, G. Gunaherath, E. Wijeratne, Jean-Philippe Lambert, A. Averette, Soo Chan Lee, Taeyup Kim, Y. Bahn, F. Tripodi, R. Ammar, Katja Döhl, K. Niewola-Staszkowska, L. Schmitt, R. Loewith, F. Roth, D. Sanglard, D. Andes, C. Nislow, P. Coccetti, A. Gingras, J. Heitman, A. Gunatilaka, L. Cowen
Nature Chemical Biology, 2016
Structures of pathogenic fungal FKBP12s reveal possible self- catalysis function
N. K. Tonthat, P. Juvvadi, Hengshan Zhang, Soo Chan Lee, R. Venters, L. Spicer, W. Steinbach, J. Heitman, M. Schumacher
Mbio, 2016
Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication
L. Corrochano, A. Kuo, M. Marcet-Houben, Silvia Polaino, A. Salamov, J. M. Villalobos-Escobedo, J. Grimwood, M. Álvarez, J. Avalos, Diane Bauer, E. P. Benito, I. Benoit, G. Burger, Lola P Camino, D. Cánovas, E. Cerdá-Olmedo, Jan-Fang Cheng, A. Dominguez, M. Eliáš, A. P. Eslava, F. Glaser, G. Gutiérrez, J. Heitman, B. Henrissat, E. A. Iturriaga, B. Lang, J. L. Lavín, Soo Chan Lee, Wenjun Li, E. Lindquist, S. López-García, Eva M. Luque, A. T. Marcos, Joel A. Martin, K. McCluskey, H. Medina, A. Miralles-Durán, A. Miyazaki, E. Muñoz-Torres, J. A. Oguiza, R. Ohm, M. Olmedo, M. Orejas, L. Ortiz-Castellanos, A. Pisabarro, J. Rodríguez-Romero, J. Ruiz-Herrera, R. Ruiz-Vazquez, Catalina Sanz, W. Schackwitz, M. Shahriari, E. Shelest, Fatima Silva-Franco, D. Soanes, K. Syed, V. G. Tagua, N. Talbot, M. Thon, H. Tice, R. D. Vries, A. Wiebenga, J. Yadav, E. Braun, S. Baker, V. Garre, J. Schmutz, B. Horwitz, S. Torres-Martínez, A. Idnurm, A. Herrera‐Estrella, T. Gabaldón, I. Grigoriev
Current Biology, 2016
Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides
Soo Chan Lee, Alicia Li, S. Calo, M. Inoue, N. K. Tonthat, J. Bain, J. Louw, M. Shinohara, L. Erwig, M. Schumacher, D. Ko, J. Heitman
Molecular Microbiology, 2015
Human fungal pathogens of Mucorales and Entomophthorales
L. Mendoza, R. Vilela, Kerstin Voelz, A. Ibrahim, K. Voigt, Soo Chan Lee
Cold Spring Harbor Perspectives in Medicine, 2015
Sex in the Mucoralean Fungi
Soo Chan Lee, J. Heitman
Mycoses, 2014
Sex and the Microsporidia
Soo Chan Lee, Joseph Heitman, Joseph E. Ironside
Microsporidia Pathogens of Opportunity First Edition, 2014
Antifungal drug resistance evoked via RNAi-dependent epimutations
Silvia Calo, Cecelia Shertz-Wall, Soo Chan Lee, Robert J. Bastidas, Francisco E. Nicolás, Joshua A. Granek, Piotr Mieczkowski, Santiago Torres-Martínez, Rosa M. Ruiz-Vázquez, Maria E. Cardenas, Joseph Heitman
Nature, 2014
Analysis of a food-borne fungal pathogen outbreak: Virulence and genome of a Mucor circinelloides isolate from yogurt
Soo Chan Lee, R. Blake Billmyre, Alicia Li, Sandra Carson, Sean M. Sykes, Eun Young Huh, Piotr Mieczkowski, Dennis C. Ko, Christina A. Cuomo, Joseph Heitman
Mbio, 2014
Unseen sex in ancient virgin fungi
Soo Chan Lee, Sheng Sun, Joseph Heitman
New Phytologist, 2014
Calcineurin Plays Key Roles in the Dimorphic Transition and Virulence of the Human Pathogenic Zygomycete Mucor circinelloides
Soo Chan Lee, Alicia Li, Silvia Calo, Joseph Heitman
Plos Pathogens, 2013
Parallels in Intercellular Communication in Oomycete and Fungal Pathogens of Plants and Humans
Soo Chan Lee, Jean B. Ristaino, Joseph Heitman
Plos Pathogens, 2012
Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases
Soo Chan Lee, Sujal Phadke, Sheng Sun, Joseph Heitman
Eukaryotic Cell, 2012
Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating
Soo Chan Lee, Joseph Heitman
Eukaryotic Cell, 2012
Know Your Enemy: How to Build and Vanquish a Global Fungal Scourge
Xuying Wang, Wenjun Li, Sheng Sun, Lukasz Kozubowski, Soo Chan Lee, Marianna Feretzaki, Joseph Heitman
Mycopathologia, 2012
Rapamycin exerts antifungal activity in vitro and in vivo against mucor circinelloides via FKBP12-dependent inhibition of tor
Robert J. Bastidas, Cecelia A. Shertz, Soo Chan Lee, Joseph Heitman, Maria E. Cardenas
Eukaryotic Cell, 2012
Sporangiospore size dimorphism is linked to virulence of mucor circinelloides
Charles H. Li, Maria Cervantes, Deborah J. Springer, Teun Boekhout, Rosa M. Ruiz-Vazquez, Santiago R. Torres-Martinez, Joseph Heitman, Soo Chan Lee
Plos Pathogens, 2011
Structure, function, and phylogeny of the mating locus in the Rhizopus oryzae complex
Andrii P. Gryganskyi, Soo Chan Lee, Anastasia P. Litvintseva, Matthew E. Smith, Gregory Bonito, Teresita M. Porter, Iryna M. Anishchenko, Joseph Heitman, Rytas Vilgalys
Plos One, 2010
Evolution of the sex-related locus and genomic features shared in microsporidia and fungi
Soo Chan Lee, Nicolas Corradi, Sylvia Doan, Fred S. Dietrich, Patrick J. Keeling, Joseph Heitman
Plos One, 2010
The evolution of sex: A perspective from the fungal kingdom
Soo Chan Lee, Min Ni, Wenjun Li, Cecelia Shertz, Joseph Heitman
Microbiology and Molecular Biology Reviews, 2010
Generation of genetic diversity in microsporidia via sexual reproduction and horizontal gene transfer
Soo Chan Lee, Louis M. Weiss, Joseph Heitman
Communicative and Integrative Biology, 2009
Signalling pathways in the pathogenesis of Cryptococcus
Lukasz Kozubowski, Soo Chan Lee, Joseph Heitman
Cellular Microbiology, 2009
Microsporidia Evolved from Ancestral Sexual Fungi
Soo Chan Lee, Nicolas Corradi, Edmond J. Byrnes, Santiago Torres-Martinez, Fred S. Dietrich, Patrick J. Keeling, Joseph Heitman
Current Biology, 2008
Aspergillus nidulans ArfB plays a role in endocytosis and polarized growth
Soo Chan Lee, Sabrina N. Schmidtke, Lawrence J. Dangott, Brian D. Shaw
Eukaryotic Cell, 2008
Localization and function of ADP ribosylation factor a in Aspergillus nidulans
Soo Chan Lee, Brian D. Shaw
FEMS Microbiology Letters, 2008
A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis
Soo Chan Lee, Brian D. Shaw
Molecular Microbiology, 2007
Effect of arsA, arsenite-specific ATPase, on inhibition of cell division in Escherichia coli
Journal of Microbiology and Biotechnology, 2001

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