Doctor - Universitas Gadjah Mada
Master - Universitas Andalas
Bachelor - Universitas Riau
RESEARCH INTERESTS
Drug Discovery
Synthesis
Organic
31
Scopus Publications
499
Scholar Citations
13
Scholar h-index
16
Scholar i10-index
Scopus Publications
Synthesis of Mannich Eugenol Oxirane Morpholine compound as antifungal in vitro and in silico Jufrizal Syahri, Siti Khotimah, Nurlaili, Nurbaiti, Rahmiwati Hilma Journal of Tropical Resources and Sustainable Science, 2025 The use of antifungal drugs increases along with the increase in fungal infections. This causes the fungus to be resistant to antifungal drugs, one of which is the azole class of drugs. This increase resistance poses a major threat to global health services. This research aims to synthesize eugenol-morpholine compound reacted with epichlorohydrin as antifungal drug in vitro and in silico. In silico testing uses the molecular docking method with the discovery studio application. Synthesis of eugenol-morpholine and synthesis of eugenol oxirane morpholine using the reflux method. Characterization of synthetic compounds using NMR. The synthesized compound was applied for in vitro testing on the Candida albicans fungus using the disc diffusion method. The results of in vitro and in silico research show that the compound eugenol oxirane morpholine has better antifungal activity compared to the compounds eugenol-morpholine and eugenol. The results of in silico research showed a cDOCKER value of -38.5537 kcal/mol and the in vitro results had an inhibition zone of 28.55 mm. The best compound as an antifungal drug candidate is the compound eugenol oxirane morpholine with the lowest cDOCKER value in in silico testing and a wide zone of inhibition in in vitro testing showing very strong activity.
Red Ginger Essential Oil (Zingiber officinale var. Rubrum) as a Biolarvicide in the Control of Aedes Aegypti Mosquitoes Denai Wahyuni, Wulan Sari, Jasril Jasril, Jufrizal Syahri Kemas, 2025 Synthetic larvicides are often used to control Aedes aegypti mosquitoes, but they are detrimental to humans, the environment, and the occurrence of resistance. The purpose of the study was to determine the influence and effectiveness of red ginger essential oil (Zingiber officinale var. Rubrum) as the biolarvicide of Ae. Aegypti and the most effective concentration (LC50). A total of 25 instar 3 larvae with concentrations of 200, 400, 600, and 800 ppm and K+(temephos), K-(aquaade), four repetitions every 30 minutes of observation for 3 HSPs. The results of the study showed that red ginger essential oil affected the death of Ae. Aegypti larvae. There was a significant difference in mortality rates between concentrations (Kruskal-Wallis test, p = 0.001). Likewise, there was a moderate but significant correlation between concentration and mortality (Spearman correlation: r = +0.503, p = 0.001). The probit analysis, LC50 was 257.89 ppm, most effectively influencing mortality in Ae. Aegypti larvae based on LC50. Red ginger essential oil (Zingiber officinale var. Rubrum) is effective and effective as a bio-larvicide to control Ae. aegypti so that it can reduce dengue fever cases.
Synthesis, Antimalarial Activities of Secondary Amine-Substituted Eugenol Compounds against Plasmodium falciparum and in silico Molecular Docking Analysis Jufrizal Syahri, Rahmiwati Hilma, Nurlaili Nurlaili, Meidita Kemala Sari, Neni Frimayanti, Amatul Hamizah Ali, Jalifah Latip Sains Malaysiana, 2023 Multi-resistance cases with antimalarial drugs had been developed in over the years. One of the ways of developing antimalarial drugs is to focus on searching for the potential antifolate inhibitors against Plasmodium sp. from synthetic or natural products. The aims of this research was to synthesis secondary amine-substituted eugenol compounds through the Mannich reaction for antimalarial evaluation using Plasmodium falciparum 3D7. The compounds were also evaluated on Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) as a protein target and the compounds’ drug-likeness properties were determined. Five secondary amine-substituted eugenol compounds (1a-e) were synthesized via substitution of the secondary amine i.e., pyrrolidine, piperidine, methyl piperidine, and morpholine in the eugenol structures. The plasmodium lactate dehydrogenase assay (pLDH) showed that 1a and 1c had good antimalarial effects against P. falciparum 3D7 with the IC50s values of 0.89 mM and 0.62 mM, respectively. The molecular docking analysis showed that 1a and 1c had perfect interaction with PfDHFR-TS (PDB ID: 1J3I) with strong hydrogen bond interactions occurring with PfDHFR-TS protein. The eugenol derivatives 1a and 1c exerted CDOCKER binding energies of -6.1407 and -6.6536 kcal/mol, respectively. Based on this research, it was found that PfDHFR-TS is a plausible protein target for the synthesized secondary amine-substituted eugenol in P. falciparum infection. The substitution of a secondary amine group for eugenol significantly enhanced the antimalarial properties of the compounds. Thus, eugenol derivatives are potential compounds to be pursued to combat folate resistance in malarial infection.
Substituted 3-styryl-2-pyrazoline Derivatives as an Antimalaria: Synthesis, in vitro Assay, Molecular Docking, Druglikeness Analysis, and ADMET Prediction Linda Ekawati Linda Ekawati, Beta Achromi Nurohmah Beta Achromi Nurohmah, Jufrizal Syahri Jufrizal Syahri, Bambang Purwono Bambang Purwono Sains Malaysiana, 2022 The synthesis, in vitro antimalarial assay, molecular docking, drug-likeness analysis, and ADMET prediction of substituted 3-styryl-2-pyrazoline derivatives as antimalaria have been conducted. The synthesis of N-phenyl (1a‒3a) and N-acetyl-substituted (1b‒3b) 3-styryl-2-pyrazolines was carried out using dibenzalacetone derivatives and hydrazine hydrate or phenylhydrazine. An in vitro antimalarial assay was conducted against the chloroquine-sensitive Plasmodium falciparum 3D7 strain, while molecular docking was performed toward the crystal protein of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) (PDB ID: 1J3I). Furthermore, the prediction of drug-like properties was determined by assessing Lipinski’s rules, and the pharmacokinetic parameters were also studied in-silico, including absorption, distribution, metabolism, excretion, and toxicity (ADMET). The in vitro assay showed that 3a (IC50 0.101 µM) has excellent antimalarial activity, followed by 2a (0.177 µM), and 1b (0.258 µM). Molecular docking has supported the in vitro assay by showing the lowest CDOCKER energy for 3a (‒56.316 kcal/mol), then 2a (‒51.2603 kcal/mol), and 1b (‒48.8774 kcal/mol). The drug-like properties showed that all of the prepared compounds were acceptable based on Lipinski’s rules and predicted to be potentially orally bioavailable. The ADMET analysis provided information that 3a and 2a could be proposed as the best lead antimalarial drugs with further modification to reduce the lipophilicity and toxicity properties.
Bio-insecticide’s Extract of Scented Root (Polygala paniculata) in Controlling the Mosquito Aedes aegypti (L.) Denai Wahyuni, N. A. Puspita, Jasril Jasril, Jufrizal Syahri, Nila Sari, et al. Makara Journal of Science, 2022 Controlling Aedes aegypti mosquitoes with chemical insecticides causes resistance on humans, environmental residues, and contaminates food and water. Polygala paniculata is a potential alternative to insecticides in controlling Ae. aegypti. This study aimed to determine the effect of the Insecticide Score of P. paniculata extracts on the mortality of Ae. aegypti mosquitoes based on KT50. A total of 20 mosquitoes for each concentration were used to examine the effectiveness of 10%, 15%, 20%, and 25% concentration of P. paniculata extracts compared to a positive and a negative control with four replications. The results showed that P. paniculata extracts had an effect on Aeaegypti mosquito mortality. There were significant differences in mortality rate between concentrations (Kruskal-Wallis test, p = 0.001). Spearman Correlation test gave a p-value of 0.008 < 0.05. Similarly, there was a weak but significant correlation between plant extract concentration and mortality (Spearman correlation: r = +0.312, p = 0.008). The 10% and 15% concentrations had KT50with Insecticide Scores of 1 and 2, respectively, implying that both had no knockdown effect. A 20% concentration had a KT50 with an Insecticide Score of 3, indicating a weak knockdown effect, whereas a 25% concentration had KT50with an Insecticide Score of 5, signifying a quick knockdown effect. These results show that a 25% concentration has a quick knockdown time on Ae. aegypti mosquitoes. Therefore, extract P. paniculata extract at a concentration of 25% has a potential for use as a bio-insecticide in controlling Ae. aegypti mosquitoes.
Synthesis, Cytotoxic Evaluation and molecular docking of bromo-substituted 1,3,6-trihydroxyxanthone as protein tyrosine kinase inhibitor Malaysian Journal of Chemistry, 2021
Effectivity of remdesivir and some compounds as therapeutic potential drugs for anti-SARS-CoV-2: In silico study Jordan Journal of Pharmaceutical Sciences, 2021
Synthesis and Molecular Docking Studies of Pyrano[2,3-c] Pyrazole-3-Carboxylates as Potential Inhibitors of Plasmodium Falciparum Malaysian Journal of Chemistry, 2020
Design of new potential antimalaria compound based on QSAR analysis of chalcone derivatives International Journal of Pharmaceutical Sciences Review and Research, 2016
RECENT SCHOLAR PUBLICATIONS
Synthesis of Mannich Eugenol Oxirane Morpholine compound as antifungal in vitro and in silico J Syahri, S Khotimah, R Hilma Journal of Tropical Resources and Sustainable Science (JTRSS) 13 (3), 187-194 , 2025 2025
Anti-malarial potential of novel aminoalkylated eugenol derivatives: synthesis, in-vitro, in-silico evaluation and mechanistic profiling J Syahri, R Hilma, M Roney, MN Uddin, MFFM Aluwi, N Frimayanti Biochemical and Biophysical Research Communications, 152725 , 2025 2025
EXTRACTION, PHYTOCHEMICAL SCREENING, TOTAL PHENOLIC CONTENT, AND ANTIBACTERIAL ACTIVITY OF MISTLETOE ON OIL PALM (Ficus heteropleura Blume) LEAVES F Hamiro, F Perdana, J Syahri Lantanida Journal 13 (2), 188-202 , 2025 2025
Synthesis, in vitro and in silico antibacterial activity test of aminoalkylated eugenol compounds J Syahri, R Hilma, Nurlaili AIP Conference Proceedings 3206 (1), 050005 , 2025 2025 Citations: 1
Red Ginger Essential Oil (Zingiber officinale var. Rubrum) as a Biolarvicide in the Control of Aedes Aegypti Mosquitoes D Wahyuni, W Sari, J Jasril, J Syahri Jurnal Kesehatan Masyarakat 20 (4), 731-743 , 2025 2025
Respons Siswa Terhadap Program Sekolah Binaan SMK Se-Riau Program Kimia Fakultas MIPA Dan Kesehatan UMRI H Nasution, SH Siregar, AP Rahayu, J Syahri, P Prasetya, R Hilma, ... Mestaka: Jurnal Pengabdian Kepada Masyarakat 4 (1), 64-69 , 2025 2025
Addition of Oil Palm Mistletoe Leaf Extract (Ficus heteropleura Blume) in Membrane Production and Antibacterial Testing of Escherichia coli Y Suryani, F Perdana, J Syahri Photon: Jurnal Sain dan Kesehatan 15 (1), 1-9 , 2024 2024 Citations: 1
Synthesis of Chalcone Derivative Compounds from 4 Chloro Acetophenone and In Silico Activity Test as Candidate Antidiabetic Compounds M Nurlaili, Jannah, J Syahri Photon: Journal of Natural Sciences and Technology 15 (1), 10-18 , 2024 2024
Studi Molecular Docking dan Evaluasi Farmakokinetik Senyawa Analog Pirazol Turunan Benzen-Sulfonilurea sebagai Inhibitor Enzim Aldose Reduktase and α-Glukosidase Menggunakan … Y Fatisa, L Utami, J Syahri, J Jasril, L Lazulva Jurnal Riset Kimia 15 (2), 11-26 , 2024 2024 Citations: 2
Synthesis and antibacterial activity test of aminoalkylated eugenol compounds in vitro and in silico J Syahri, Nurlaili, AA Rahim, R Dhony, SO Zulya, S Wahyuningsih AIP Conference Proceedings 3027 (1), 020008 , 2024 2024 Citations: 2
Pelatihan Pembuatan Pupuk Kompos Limbah Kulit Nangka Bagi Masyarakat Desa Kualu Nenas-Kab. Kampar RI Putri, H Nasution, R Syafitri, P Khorely, F Perdana, R Syafri, J Syahri, ... Jurnal Pengabdian UntukMu NegeRI 8 (1), 144-149 , 2024 2024 Citations: 3
Pembuatan nugget dari biji nangka upaya mengoptimalkan sumber daya masyarakat Desa Kualu Nenas H Nasution, RI Putri, R Hidayati, P Prasetya, F Perdana, R Syafri, J Syahri, ... Jurnal Pengabdian Kepada Masyarakat Nusantara 4 (4), 4870-4876 , 2023 2023 Citations: 3
Synthesis, Antimalarial Activities of Secondary Amine-Substituted Eugenol Compounds against Plasmodium falciparum and in silico Molecular Docking Analysis J Syahri, R Hilma, N Nurlaili, MK Sari, N Frimayanti, AH Ali, J Latip Sains Malaysiana 52 (12), 3463-3474 , 2023 2023 Citations: 9
Chalcone Mannich base derivatives: synthesis, antimalarial activities against Plasmodium knowlesi, and molecular docking analysis J Syahri, R Hilma, AH Ali, N Ismail, NY Ling, BA Nurohmah, HK Agustar, ... RSC advances 13 (51), 36035-36047 , 2023 2023 Citations: 24
Ekstraksi, Fraksinasi, Dan Uji Antioksidan Daun Pakis Sawit (Davallia denticulata) E Norhaslinda, J Syahri, F Perdana Photon: Journal of Natural Sciences and Technology 13 (2), 18-27 , 2023 2023 Citations: 8
Synthesis, characterization, biological evaluation, and docking simulation of chalcone derivatives as potent antibacterial agents J Syahri, R Hilma, Nurlaili, H Saputri, SZ Nasution, BA Nurohmah PROCEEDING OF THE 7TH INTERNATIONAL CONFERENCE OF SCIENCE, TECHNOLOGY, AND … , 2023 2023 Citations: 2
Workshop Sertifikasi Pranata Laboratorium Untuk Guru Sains Tingkat SLTA Se-Provinsi Riau SH Siregar, P Prasetya, H Nasution, R Hilma, F Perdana, R Syafri, ... Jurnal Pengabdian UntukMu NegeRI 7 (1), 118-123 , 2023 2023
Evaluation of the Antibacterial Activity of the Jackfruit Parasite Leaf Plant Extract (Macrosolencochinchinensis (Lour.) van Tiegh) with Vitro and In Silico approach R Hilma, SR Harahap, J Syahri Acta Chimica Asiana 5 (2), 229-236 , 2022 2022 Citations: 3
Bio-insecticide’s Extract of Scented Root (Polygala paniculata) in Controlling the Mosquito Aedes aegypti (L.) D Wahyuni, NP Sari, J Jasril, J Syahri Makara Journal of Science 26 (2), 4 , 2022 2022 Citations: 6
Pemberdayaan Ekonomi Dasawisma Rantau Kopar, Rokan Hilir dengan “SaMaKiRi”(Sabun Mahasiswa Kimia UMRI) R Syafri, J Syahri, R Hilma, H Nasution, SH Siregar, F Perdana Jurnal Pengabdian UntukMu NegeRI 6 (1), 135-140 , 2022 2022
MOST CITED SCHOLAR PUBLICATIONS
Chalcone analogue as potent anti-malarial compounds against Plasmodium falciparum: Synthesis, biological evaluation, and docking simulation study J Syahri, E Yuanita, BA Nurohmah, R Armunanto, B Purwono Asian Pacific Journal of Tropical Biomedicine 7 (8), 675-679 , 2017 2017 Citations: 89
Xanthone as Antimalarial: QSAR analysis, synthesis, molecular docking and in-vitro antimalarial evaluation J Syahri, E Yuanita, ... Oriental Journal of Chemistry 33 (1), 29-40 , 2017 2017 Citations: 38
Quantitative structure–activity relationship (QSAR) and molecular docking of xanthone derivatives as anti-tuberculosis agents E Yuanita, NKT Dharmayani, M Ulfa, J Syahri Journal of Clinical Tuberculosis and Other Mycobacterial Diseases 21, 100203 , 2020 2020 Citations: 34
Pengukuran Total Fenolik, Flavonoid, Aktivitas Antioksidan dan Antidiabetes Ekstrak Etil Asetat Daun Katemas (Euphorbia heterophylla, L.) Secara In Vitro dan In Silico Melalui … R Hilma, N Gustina, J Syahri ALCHEMY Jurnal Penelitian Kimia 16 (2), 240 , 2020 2020 Citations: 30
Novel aminoalkylated chalcone: Synthesis, biological evaluation, and docking simulation as potent antimalarial agents J Syahri, H Nasution, BA Nurohmah, B Purwono, E Yuanita J Appl Pharm Sci 10 (06), 001-005 , 2020 2020 Citations: 30
Chalcone Mannich base derivatives: synthesis, antimalarial activities against Plasmodium knowlesi, and molecular docking analysis J Syahri, R Hilma, AH Ali, N Ismail, NY Ling, BA Nurohmah, HK Agustar, ... RSC advances 13 (51), 36035-36047 , 2023 2023 Citations: 24
SYNTHESIS, CHARACTERIZATION AND MOLECULAR DOCKING OF CHLORO-SUBSTITUTED HYDROXYXANTHONE DERIVATIVES E Yuanita, HD Pranowo, M Mustofa, RT Swasono, J Syahri, J Jumina CHEMISTRY JOURNAL OF MOLDOVA 14 (1), 68-76 , 2019 2019 Citations: 22
Synthesis, biological evaluation, QSAR analysis, and molecular docking of chalcone derivatives for antimalarial activity J Syahri, K Rullah, R Armunanto, E Yuanita, BA Nurohmah, MFFM Aluwi, ... parasite 4, 8 , 2017 2017 Citations: 22
One-pot synthesis, antioxidant activity and toxicity evaluation of some hydroxyxanthones Emmy Yuanita, Harno Dwi Pranowo, Dwi Siswanta Swasono, Jufrizal Syahri Chemistry and Chemical Technology 12 (3), 290-295 , 2018 2018 Citations: 19
Some 2-Arylbenzimidazole Derivatives as An Antimalarial Agent: Synthesis, Activity Assay, Molecular Docking and Pharmacological Evaluation B Purwono, BA Nurohmah, FZ Fathurrohman, J Syahri Rasayan Journal of Chemistry 14 (1), 94-100 , 2021 2021 Citations: 16
Design of new potential antimalaria compound based on QSAR analysis of chalcone derivatives J Syahri, B Purwono, R Armunanto Int J Pharm Sci Rev Res 36 (2), 71-76 , 2016 2016 Citations: 15
Design, Synthesis and Biological Evaluation of Aminoalkylated Chalcones as Antimalarial Agent J Syahri, H Nasution, BA Nurohmah, B Purwono, E Yuanita, NH Zakaria, ... Sains Malaysiana 49 (11), 2667-2677 , 2020 2020 Citations: 13
Antibacterial activity and molecular docking studies of series hydroxyxanthone E Yuanita, IM Sudarma, NM Sudewiningsih, J Syahri, NKT Dharmayani, ... AIP Conference Proceedings 2243 (1), 020032 , 2020 2020 Citations: 13
Synthesizing derivatives from cyclopentanone analogue curcumin and their toxic, antioxidant and anti-inflammatory activities Y Eryanti, Y Nurulita, R Hendra, Y Yuharmen, J Syahri, A Zamri Makara Journal of Science 15 (2), 4 , 2012 2012 Citations: 12
Synthesis and Docking Study of 2–Aryl-4, 5-diphenyl-1 H-imidazole Derivatives as Lead Compounds for Antimalarial Agent I Septiana, B Purwono, C Anwar, BA Nurohmah, J Syahri Indonesian Journal of Chemistry , 2022 2022 Citations: 11
Synthesis and Molecular Docking Studies of Pyrano[2,3-c] Pyrazole-3-Carboxylates as Potential Inhibitors of Plasmodium Falciparum MA Shamsuddin, NH Zakaria, MF Mohammat, J Syahri, J Latip, NI Hassan Malaysian Journal of Chemistry 22 (4), 52-61 , 2020 2020 Citations: 10
Synthesis, Antimalarial Activities of Secondary Amine-Substituted Eugenol Compounds against Plasmodium falciparum and in silico Molecular Docking Analysis J Syahri, R Hilma, N Nurlaili, MK Sari, N Frimayanti, AH Ali, J Latip Sains Malaysiana 52 (12), 3463-3474 , 2023 2023 Citations: 9
Ekstraksi, Fraksinasi, Dan Uji Antioksidan Daun Pakis Sawit (Davallia denticulata) E Norhaslinda, J Syahri, F Perdana Photon: Journal of Natural Sciences and Technology 13 (2), 18-27 , 2023 2023 Citations: 8
Pelatihan pembuatan publikasi ilmiah guru-guru sma n 2 tambang kabupaten kampar J Syahri, R Hilma, H Nasution, P Prasetya, R Syafri, SH Siregar, N Nurlaili Jurnal Pengabdian UntukMu NegeRI 2 (1), 43-49 , 2018 2018 Citations: 8
Synthesis, Cytotoxic Evaluation and Molecular Docking of Bromo-Substituted 1, 3, 6-Trihydroxyxanthone as Protein Tyrosine Kinase Inhibitor E Yuanita, M Ulfa, Sudirman, I Sumarlan, IM Sudarma, NKT Dharmayani, ... Malaysian Journal of Chemistry 23 (1), 24-32 , 2021 2021 Citations: 7
