JOSE DE MAGALHAES

@ufsj.edu.br

Full professor and researcher at the Department of Chemistry, Biotechnology and Bioprocess Engineering.
Federal University of Sao Joao del-Rei

JOSE DE MAGALHAES


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https://researchid.co/josecarlos

RESEARCH, TEACHING, or OTHER INTERESTS

Microbiology, Drug Discovery, Biomedical Engineering, Biotechnology
43

Scopus Publications

1466

Scholar Citations

20

Scholar h-index

37

Scholar i10-index

Scopus Publications

  • Silymarin Attenuates Arthritis and Myositis in a Murine Model of Acute Infection by Chikungunya and Mayaro Viruses
    Rafaela Lameira Souza Lima, Ariane Coelho Ferraz, Marília Bueno da Silva Menegatto, Oluwashola Samuel Ola-Olu, Pedro Henrique Guimarães, Giovana Mesquita Oliveira de Castro Domingos, Allen Rene Ruiz Hernández, Maria Eduarda Diniz Starling, Pedro Alves Machado-Junior, Frank Silva Bezerra, José Carlos de Magalhães, Wanderson Geraldo de Lima, Cintia Lopes de Brito Magalhães
    ACS Infectious Diseases, 2026
    The alphaviruses chikungunya (CHIKV) and Mayaro (MAYV) are responsible for acute febrile illnesses often accompanied by severe and persistent joint and muscle pain. Due to the lack of specific treatment, research into antivirals against these emerging viruses is seen as an urgent need. Previous studies demonstrated that silymarin exhibits potent antiviral activity against CHIKV and MAYV. Then, given the promising antiviral profile of silymarin, and the prominent joint and muscle pain caused by these viruses, we evaluated whether silymarin could reverse these damages in a murine model of alphavirus-induced arthritis and myositis. BALB/c mice were infected with CHIKV or MAYV in the right hind paw pad, and treated groups received silymarin orally (200 mg/kg/day). Clinical observation revealed reduced paw edema in silymarin-treated animals. At 7 and 12 days postinfection (dpi), animals were euthanized and various tissues collected. In infected and treated animals, a greater than 90% reduction in CHIKV viral load was observed in the spleen (7 and 12 dpi), paw (7 dpi), soleus muscle, and liver (12 dpi). Similarly, for MAYV, a greater than 90% reduction in viral load was detected in the spleen (7 and 12 dpi), liver, quadriceps, soleus muscle (7 dpi), and paw (12 dpi). Histological analysis revealed reduced inflammatory infiltrates in the liver, paw, and muscles as well as a decrease in both the number and area of lymphoid nodules in the spleen (12 dpi). Furthermore, silymarin treatment reduced TNF-α levels by at least 2-fold in the paw (7 and 12 dpi) and quadriceps (12 dpi). These findings suggest that silymarin not only limits viral replication in key target tissues, including the spleen, liver, muscle, and paw, but also mitigates inflammation by reducing paw edema, inflammatory infiltrates in hepatic, musculoskeletal, and paw tissues, the number and area of lymphoid nodules in the spleen, and TNF-α levels in the quadriceps muscle and paw, thereby supporting its therapeutic potential against CHIKV and MAYV infections.
  • Vaccinia virus modulates the redox environment by inhibiting reactive oxygen and nitrogen species with increased activity of endogenous antioxidant enzymes
    Marília Bueno da Silva Menegatto, Ariane Coelho Ferraz, Rafaela Lameira Souza Lima, Pedro Henrique Guimarães, Oluwashola Samuel Ola-Olu, Pedro Alves Machado-Junior, Wellington Carvalho Malta, Thaís de Fátima Silva Moraes, Frank Silva Bezerra, Breno de Mello Silva, José Carlos de Magalhães, Jordana Grazziela Alves Coelho dos Reis, Flávio Guimarães da Fonseca, Giliane de Souza Trindade, Erna Geessien Kroon, Cintia Lopes de Brito Magalhães
    Scientific Reports, 2025
    The vaccinia virus (VACV) is the most studied and well-characterised member of the Poxviridae family. However, the mechanisms through which it modulates redox homeostasis in host cells remain unclear. Although oxidative stress, which is marked by elevated levels of reactive species, contributes to the pathogenesis of many viral infections, poxviruses may adopt distinct strategies. VACV has redox effector proteins that are released into the cytosol when the virus penetrates the host cell. This study demonstrates for the first time that VACV infection leads to the activation of the nuclear factor erythroid 2 (Nrf2)/antioxidant response element pathway, a key regulator of cellular antioxidant responses, a mechanism not previously described for any poxvirus. Using BSC-40 cells, we observed that VACV significantly reduced reactive oxygen and nitrogen species levels, downregulated inducible nitric oxide synthase, and enhanced the activity of antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase. This antioxidant shift is correlated with increased Nrf2 activity and the upregulation of its downstream targets. This virus-induced antioxidant state may be an immunomodulatory mechanism that facilitates viral replication by dampening host defence. Thus, our findings expand the current understanding of virus-host interactions in poxvirus infections.
  • Silymarin exerts antioxidant and antiviral effects on Zika virus infection
    Rafaela Lameira Souza Lima, Marília Bueno da Silva Menegatto, Letícia Trindade Almeida, José Carlos de Magalhães, Ariane Coelho Ferraz, Cintia Lopes de Brito Magalhães
    Journal of Virological Methods, 2025
  • Activity of extracts and terpenoids from Tontelea micrantha (Mart. ex Schult.) A.C.Sm. (Celastraceae) against pathogenic bacteria
    Ranieli Paiva Lopes, Fernanda Lopes Ferreira, Grasiely Faria de Sousa, Waleska Stephanie da Cruz Nizer, Cintia Lopes de Brito Magalhães, Jaqueline Maria Siqueira Ferreira, Antônio Helvécio Tótola, Lucienir Pains Duarte, José Carlos de Magalhães
    Natural Product Research, 2025
    The pharmacological properties of plant extracts and phytochemicals, such as flavonoids and terpenoids, remain of great interest. In this work, the effect of extracts, friedelan-3,21-dione, and 3β-O-D-glucosyl-sitosterol isolated from Tontelea micrantha roots was evaluated against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Klebsiella oxytoca and Escherichia coli. The antibacterial activity was evaluated by the minimum inhibitory and bactericidal concentrations (MIC and MBC, respectively), and the synergistic effect was assessed by the Checkerboard assay. Furthermore, the cytotoxicity of the plant-derived compounds against Vero cells was measured by the 3-(4 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide (MTT) method. The biological effects of the isolated compounds were predicted using the PASS online software. The chloroform and hexane extracts of T. micrantha roots showed promising antibacterial effect, with MIC in the range of 4.8-78.0 µg/mL. Further analyses showed that these compounds do not affect the integrity of the membrane. The combination with streptomycin strongly reduced the MIC of this antibiotic and extracts. The extracts were highly toxic to Vero cells, and no cytotoxicity was detected for the two terpenoids isolated from them (i.e. friedelan-3,21-dione and 3β-O-D-glucosyl-sitosterol; CC50 > 1000 μg/mL). Therefore, extracts obtained from T. micrantha roots significantly inhibited bacterial growth and are considered promising agents against pathogenic bacteria. The cytotoxicity results were very relevant and can be tested in bioassays.
  • Flavonoids and Triterpenoids Isolated From the Ethyl Acetate Extract of M. quadrangulata Leaves
    Mariana Guerra de Aguilar, Sandy Veríssimo Morais Quintão, Karen Caroline Camargo, Lucienir Pains Duarte, Laisa Resende Vasconcelos, José Carlos de Magalhães, Grasiely Faria de Sousa
    Chemistry and Biodiversity, 2024
    The new flavonoid (−)‐4’‐O‐methylepicatechin 5‐O‐β‐D‐glucopyranoside (1), along with four known triterpenes (2‐5), a steroid (6), and a flavonoid (7) were isolated from the ethyl acetate extract of Maytenus quadrangulata leaves. The chemical structures of the isolated compounds were determined through analysis of 1D NMR (1H and 13C) spectroscopic data, in addition to 2D NMR and spectrometric (MS) data for compound 1. This is the first report of the isolation of daucosterol (6) and (−)‐4’‐O‐methylepigallocatechin (7) from this species. Compounds 1 and 7 were evaluated against the bacteria Staphylococcus aureus and Klebsiella pneumoniae, but neither exhibited activity even at the highest concentration tested.
  • Exploring the antiviral potential of justicidin B and four glycosylated lignans from Phyllanthus brasiliensis against Zika virus: A promising pharmacological approach
    Ariane Coelho Ferraz, Paulo Wender P. Gomes, Marília Bueno da Silva Menegatto, Rafaela Lameira Souza Lima, Pedro Henrique Guimarães, José Diogo Evangelista Reis, Alice Rhelly Veloso Carvalho, Sônia das Graças Santa Rosa Pamplona, Abraão de Jesus Barbosa Muribeca, José Carlos de Magalhães, Consuelo Yumiko Yoshioka e Silva, Milton Nascimento da Silva, Cintia Lopes de Brito Magalhães
    Phytomedicine, 2024
  • Untargeted-based metabolomics analysis and in vitro/in silico antiviral activity of extracts from Phyllanthus brasiliensis (Aubl.) Poir
    Alice Rhelly V. Carvalho, José Diogo E. Reis, Paulo Wender P. Gomes, Ariane Coelho Ferraz, Horrana A. Mardegan, Marília Bueno da Silva Menegatto, Rafaela Lameira Souza Lima, Maria Rosilda V. de Sarges, Sônia das G. S. R. Pamplona, Karen Sartori Jeunon Gontijo, José Carlos de Magalhães, Milton N. da Silva, Cintia Lopes de Brito Magalhães, Consuelo Yumiko Yoshioka e Silva
    Phytochemical Analysis, 2023
    IntroductionThis study describes the molecular profile and the potential antiviral activity of extracts from Phyllanthus brasiliensis, a plant widely found in the Brazilian Amazon. The research aims to shed light on the potential use of this species as a natural antiviral agent.MethodsThe extracts were analysed using liquid chromatography–mass spectrometry (LC–MS) system, a potent analytical technique to discover drug candidates. In the meantime, in vitro antiviral assays were performed against Mayaro, Oropouche, Chikungunya, and Zika viruses. In addition, the antiviral activity of annotated compounds was predicted by in silico methods.ResultsOverall, 44 compounds were annotated in this study. The results revealed that P. brasiliensis has a high content of fatty acids, flavones, flavan‐3‐ols, and lignans. Furthermore, in vitro assays revealed potent antiviral activity against different arboviruses, especially lignan‐rich extracts against Zika virus (ZIKV), as follows: methanolic extract from bark (MEB) [effective concentration for 50% of the cells (EC50) = 0.80 μg/mL, selectivity index (SI) = 377.59], methanolic extract from the leaf (MEL) (EC50 = 0.84 μg/mL, SI = 297.62), and hydroalcoholic extract from the leaf (HEL) (EC50 = 1.36 μg/mL, SI = 735.29). These results were supported by interesting in silico prediction, where tuberculatin (a lignan) showed a high antiviral activity score.ConclusionsPhyllanthus brasiliensis extracts contain metabolites that could be a new kick‐off point for the discovery of candidates for antiviral drug development, with lignans becoming a promising trend for further virology research.
  • Virucidal antiviral activity of Maytenus quadrangulata extract against Mayaro virus: Evidence for the presence of catechins
    Damiana Antônia de Fátima Nunes, Gabriela Francine Martins Lopes, Waleska Stephanie da Cruz Nizer, Mariana G. de Aguilar, Felipe Rocha da Silva Santos, Grasiely Faria de Sousa, Ariane Coelho Ferraz, Lucienir Pains Duarte, Geraldo Célio Brandão, Sidney Augusto Vieira-Filho, Cintia Lopes de Brito Magalhães, Jaqueline Maria Siqueira Ferreira, José Carlos de Magalhães
    Journal of Ethnopharmacology, 2023
  • Cytotoxicity, structural, conformational, and techno-functional properties of α-lactalbumin nanostructured aggregates
    Jhonatan Rafael de Oliveira Bianchi, Bruna Elisa Reis Paz, Larissa Germano Fonseca, Rebeca Lima Carvalho, José Carlos Magalhães, Karina Azevedo Pacheco, Andersen Escobar Schlogl, Daniela Leite Fabrino, Edson Romano Nucci, Jane Sélia dos Reis Coimbra, Igor José Boggione Santos
    Journal of Food Science, 2023
    Protein nanostructures can be used in food applications to improve the techno‐functional properties of a food formulation. This study aims to find the best conditions for the production and conformational change of α‐lactalbumin nanostructured aggregates. The criteria to determine the best operating conditions to produce α‐lactalbumin nanostructured aggregates were intensification of foaming and emulsification, techno‐functional proprieties, cytotoxic, and antibacterial activity of nanostructures compared with native α‐lactalbumin. Conformational alterations occurred in the α‐helix and sheet‐β protein structures. The size obtained by dynamic light scattering was 163.84 nm with a polydispersity index of 0.29. The nano protein improved the techno‐functional property compared to the native protein. Additionally, nanostructures had no cytotoxic effect and were innocuous to bacterial activity. Thus, this study presents the best conditions to produce α‐lactalbumin nanostructured aggregates with improved properties that allow new food industry applications.
  • Oropouche virus infection induces ROS production and oxidative stress in liver and spleen of mice
    Marília Bueno da Silva Menegatto, A. Ferraz, R. Lima, Letícia T. Almeida, R. D. De Brito, A. B. Reis, C. Carneiro, W. G. de Lima, Breno de Mello Silva, J. D. de Magalhães, C. L. D. B. Magalhães
    Journal of General Virology, 2023
    Oropouche virus (OROV) is the aetiological agent of Oropouche fever, the symptoms of which are common to most arboviruses, such as fever, headache, malaise, nausea and vomiting. More than half a million people have been infected with OROV since its isolation in 1955. Although Oropouche fever is classified as a neglected and emerging disease, to date, there are no antiviral drugs or vaccines available against the infection and little is known about its pathogenicity. Therefore, it is essential to elucidate the possible mechanisms involved in its pathogenesis. Since oxidative stress plays a pivotal role in the progression of various viral diseases, in this study, redox homeostasis in the target organs of OROV infection was evaluated using an animal model. Infected BALB/c mice exhibited reduced weight gain, splenomegaly, leukopenia, thrombocytopenia, anaemia, development of anti-OROV neutralizing antibodies, increased liver transaminases, and serum levels of pro-inflammatory cytokines tumour necrosis factor (TNF-α) and interferon-γ (IFN-γ). The OROV genome and infectious particles were detected in the liver and spleen of infected animals, with liver inflammation and an increase in the number and total area of lymphoid nodules in the spleen. In relation to redox homeostasis in the liver and spleen, infection led to an increase in reactive oxygen species (ROS) levels, increased oxidative stress biomarkers malondialdehyde (MDA) and carbonyl protein, and decreased activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). Taken together, these results help elucidate some important aspects of OROV infection that may contribute to the pathogenesis of Oropouche.
  • Anti-Mayaro virus activity of a hydroethanolic extract from Fridericia chica (Bonpl.) L. G. Lohmann leaves
    Gabriela F.M. Lopes, Willam G. Lima, Felipe R.S. Santos, Damiana A.F. Nunes, Maria J.F. Passos, Simone O.A. Fernandes, José C. de Magalhães, Luciana L. dos Santos, Jaqueline M.S. Ferreira
    Journal of Ethnopharmacology, 2022
  • NS2B-NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review
    Damiana Antônia de Fátima Nunes, Felipe Rocha da Silva Santos, Sara Thamires Dias da Fonseca, William Gustavo de Lima, Waleska Stephanie da Cruz Nizer, Jaqueline Maria Siqueira Ferreira, José Carlos de Magalhães
    Journal of Medical Virology, 2022
  • Netzahualcoyonol from Salacia multiflora (Lam.) DC. (Celastraceae) roots as a bioactive compound against gram-positive pathogens
    Waleska Stephanie da Cruz Nizer, Ariane Coelho Ferraz, Thaís de Fátima Silva Moraes, William Gustavo Lima, Josana Pereira dos Santos, Lucienir Pains Duarte, Cintia Lopes de Brito Magalhães, Sidney Augusto Vieira-Filho, José Carlos de Magalhães
    Natural Product Research, 2022
  • A methanol extract and N,N-dimethyltryptamine from Psychotria viridis Ruiz & Pav. inhibit Zika virus infection in vitro
    Thaís F. S. Moraes, Ariane C. Ferraz, Waleska S. da Cruz Nizer, Antônio H. Tótola, Débora B. S. Soares, Lucienir P. Duarte, Sidney A. Vieira-Filho, Cintia L. B. Magalhães, José C. de Magalhães
    Archives of Virology, 2021
  • Hepatoprotective, antioxidant, anti-inflammatory, and antiviral activities of silymarin against mayaro virus infection
    Ariane Coelho Ferraz, Letícia Trindade Almeida, Camila Carla da Silva Caetano, Marília Bueno da Silva Menegatto, Rafaela Lameira Souza Lima, Joao Pinto Nelson de Senna, Jamille Mirelle de Oliveira Cardoso, Luiza Oliveira Perucci, André Talvani, Wanderson Geraldo de Lima, Breno de Mello Silva, Alexandre Barbosa Reis, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães
    Antiviral Research, 2021
  • Pristimerin isolated from Salacia crassifolia (Mart. Ex. Schult.) G. Don. (Celastraceae) roots as a potential antibacterial agent against Staphylococcus aureus
    Waleska Stephanie da Cruz Nizer, Ariane Coelho Ferraz, Thaís de Fátima Silva Moraes, William Gustavo Lima, Josana Pereira dos Santos, Lucienir Pains Duarte, Jaqueline Maria Siqueira Ferreira, Cintia Lopes de Brito Magalhães, Sidney Augusto Vieira-Filho, Ana Claúdia dos Santos Pereira Andrade, Rodrigo Araújo Lima Rodrigues, Jonatas Santos Abrahão, José Carlos de Magalhães
    Journal of Ethnopharmacology, 2021
  • Bauhinia holophylla (Bong.) Steud. leaves-derived extracts as potent anti-dengue serotype 2
    Michelli dos Santos, Thaiz Rodrigues Teixeira, Felipe Rocha da Silva Santos, William Gustavo Lima, Ariane Coelho Ferraz, Nathália Lucca Silva, Flávio José Leite, João Máximo Siqueira, Walter Luyten, Ana Hortência Fonseca de Castro, José Carlos de Magalhães, Jaqueline Maria Siqueira Ferreira
    Natural Product Research, 2021
  • Antiviral effect of silymarin against Zika virus in vitro
    Tales Fernando da Silva, Ariane Coelho Ferraz, Letícia Trindade Almeida, Camila Carla da Silva Caetano, Fernanda Caetano Camini, Rafaela Lameira Souza Lima, Ana Cláudia dos Santos Pereira Andrade, Danilo Bretas de Oliveira, Kamila Lorene Soares Rocha, Breno de Mello Silva, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães
    Acta Tropica, 2020
  • Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo
    Letícia Trindade Almeida, Ariane Coelho Ferraz, Camila Carla da Silva Caetano, Marília Bueno da Silva Menegatto, Ana Cláudia dos Santos Pereira Andrade, Rafaela Lameira Souza Lima, Fernanda Caetano Camini, Samille Henriques Pereira, Karla Yanca da Silva Pereira, Breno de Mello Silva, Luiza Oliveira Perucci, André Talvani, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães
    Virus Research, 2020
  • Lack of activity of rutin isolated from Tontelea micrantha leaves against Vero and BHK, fungi, bacteria and Mayaro virus and its in silico activity
    JoséCarlos De Magalhães, WaleskaStephanie Da Cruz Nizer, ArianeCoelho Ferraz, ThaisDe Fatima Silva Moraes, FernandaLopes Ferreira, CintiaLopes De Brito Magalhães, SidneyAugusto Vieira-Filho, LucenirPains Duarte
    Journal of Pharmaceutical Negative Results, 2020
  • Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model
    Camila Carla da Silva Caetano, Fernanda Caetano Camini, Letícia Trindade Almeida, Ariane Coelho Ferraz, Tales Fernando da Silva, Rafaela Lameira Souza Lima, Mayara Medeiros de Freitas Carvalho, Thalles de Freitas Castro, Cláudia Martins Carneiro, Breno de Mello Silva, Silvana de Queiroz Silva, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães
    Scientific Reports, 2019
  • Virucidal activity of proanthocyanidin against Mayaro virus
    Ariane Coelho Ferraz, Thaís de Fátima Silva Moraes, Waleska Stephanie da Cruz Nizer, Michelli dos Santos, Antônio Helvécio Tótola, Jaqueline Maria Siqueira Ferreira, Sidney Augusto Vieira-Filho, Vanessa Gonçalves Rodrigues, Lucienir Pains Duarte, Cintia Lopes de Brito Magalhães, José Carlos de Magalhães
    Antiviral Research, 2019
  • Zika Virus Activity of the Leaf and Branch Extracts of Tontelea micrantha and Its Hexane Extracts Phytochemical Study
    Fernanda Ferreira, Marcela Hauck, Lucienir Duarte, José Magalhães, Louise da Silva, Lúcia Pimenta, Julio Lopes, Maria Mercadante‑Simões, Sidney Vieira
    Journal of the Brazilian Chemical Society, 2019
  • Antiviral activity of silymarin against Mayaro virus and protective effect in virus-induced oxidative stress
    Fernanda Caetano Camini, Tales Fernando da Silva, Camila Carla da Silva Caetano, Letícia Trindade Almeida, Ariane Coelho Ferraz, Verônica Maria Alves Vitoreti, Breno de Mello Silva, Silvana de Queiroz Silva, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães
    Antiviral Research, 2018
  • Detection of the antiviral activity of epicatechin isolated from Salacia crassifolia (Celastraceae) against Mayaro virus based on protein C homology modelling and virtual screening
    P. G. Ferreira, A. C. Ferraz, J. E. Figueiredo, C. F. Lima, V. G. Rodrigues, A. G. Taranto, J. M. S. Ferreira, G. C. Brandão, S. A. Vieira-Filho, L. P. Duarte, C. L. de Brito Magalhães, J. C. de Magalhães
    Archives of Virology, 2018
  • High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil
    Anna Carolina Toledo da Cunha Pereira, Tatiane Ribeiro de Siqueira, Andressa Anunciação de Oliveira Prado, Camila Almeida Veiga da Silva, Thaís de Fátima Silva Moraes, Alan Alex Aleixo, José Carlos de Magalhaes, Gabriel Augusto Pires de Souza, Betânia Paiva Drumond, Gustavo Portela Ferreira, Breno de Mello Silva, Cintia Lopes de Brito Magalhães, Luciana Lara Santos, Jaqueline Maria Siqueira Ferreira, Luiz Cosme Cotta Malaquias, Luiz Felipe Leomil Coelho
    Immunogenetics, 2018
  • Pharmacophoric characteristics of dengue virus NS2B/NS3pro inhibitors: a systematic review of the most promising compounds
    Camyla Alves Leonel, William Gustavo Lima, Michelli dos Santos, Ariane Coelho Ferraz, Alex Gutterres Taranto, José Carlos de Magalhães, Luciana Lara dos Santos, Jaqueline Maria Siqueira Ferreira
    Archives of Virology, 2018
  • Evaluation of the activity of Tontelea micrantha extracts against bacteria, Candida and Mayaro virus
    JoséCarlos De Magalhães, WaleskaStephanie Cruz, ArianeCoelho Ferraz, WilliamGustavo Lima, ThaísFátima Silva Moraes, FernandaLopes Ferreira, JaquelineMaria Siqueira Ferreira, CintiaLopes De Brito Magalhães, LucienirPains Duarte, SidneyAugusto Vieira Filho
    Journal of Pharmaceutical Negative Results, 2018
  • Antibacterial and antifungal activities of phenolic compound-enriched ethyl acetate fraction from Cochlospermum regium (mart. Et. Schr.) Pilger roots: Mechanisms of action and synergism with tannin and gallic acid
    R.S. Carvalho, C.A. Carollo, J.C. de Magalhães, J.M.C. Palumbo, A.G. Boaretto, I.C. Nunes e Sá, A.C. Ferraz, W.G. Lima, J.M. de Siqueira, J.M.S. Ferreira
    South African Journal of Botany, 2018
  • Triazole-chalcones: Lack of antibacterial, anti-candida, and anti-dengue virus activities
    JaquelineMaria Siqueira Ferreira, Michellidos Santos, FelipeRocha Da Silva Santos, ArianeCoelho Ferraz, JéssicaTauany Andrade, KarinaMarjorie Silva Herrera, WilliamGustavo Lima, LailahHorácio Sales Pereira, MarinaGoulart da Silva, JoséAugusto Ferreira Perez Villar, JoséCarlos de Magalhães, AlexGutterres Taranto, LucianaLara dos Santos, JamáriaAdriana Pinheiro Soares-Martins
    Journal of Pharmaceutical Negative Results, 2018
  • Oxidative stress in Mayaro virus infection
    Fernanda Caetano Camini, Camila Carla da Silva Caetano, Letícia Trindade Almeida, Joyce Ferreira da Costa Guerra, Breno de Mello Silva, Silvana de Queiroz Silva, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães
    Virus Research, 2017
  • Dengue virus detection in Aedes aegypti larvae from southeastern Brazil
    Samyra Giarola Cecílio, Willer Ferreira Silva Júnior, Antônio Helvécio Tótola, Cíntia Lopes de Brito Magalhães, Jaqueline Maria Siqueira Ferreira, José Carlos de Magalhães
    Journal of Vector Ecology, 2015
  • Dengue outbreaks in Divinopolis, south-eastern Brazil and the geographic and climatic distribution of Aedes albopictus and Aedes aegypti in 2011-2012
    Martinelle Ferreira da Rocha Taranto, José Eduardo Marques Pessanha, Michelli dos Santos, Ana Cláudia dos Santos Pereira Andrade, Vidyleison Neves Camargos, Stênio Nunes Alves, Cláudia Di Lorenzo Oliveira, Alex Gutterres Taranto, Luciana Lara dos Santos, José Carlos de Magalhães, Erna Geessien Kroon, Leandra Barcelos Figueiredo, Betânia Paiva Drumond, Jaqueline Maria Siqueira Ferreira
    Tropical Medicine and International Health, 2015
  • Caraparu virus induces damage and alterations in antioxidant defenses in the liver of BALB/c mice after subcutaneous infection
    Fernanda Caetano Camini, Letícia Trindade Almeida, Carolina Silva Bernardes, Maísa Silva, Maria Lúcia Pedrosa, Daniela Caldeira Costa, Wanderson Geraldo de Lima, Carla do Amaral Pinto, Paulo César Peregrino Ferreira, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães
    Archives of Virology, 2014
  • Phytotherapy: An introduction to its history, use and application
    T.S. Ferreira, C.Z. Moreira, N. Z. Cária, G. Victoriano, W.F. SILVA Jr, J.C. Magalhães
    Revista Brasileira De Plantas Medicinais, 2014
  • Cytotoxicity, Anti-poliovirus activity and in silico biological evaluation of constituents from maytenus gonoclada (celastraceae)
    International Journal of Pharmacy and Pharmaceutical Sciences, 2014
  • Assessment of antimicrobial activity in vitro of ethanolic extracts of Banisteriopsis anisandra (A. Juss.) B. Gates (Malpighiaceae)
    M.S. Pádua, M.C. Mendes-Costa, J.M.S. Ferreira, J.C. Magalhães, A.H.F. Castro
    Revista Brasileira De Plantas Medicinais, 2013
  • Combination of extracts from Aristolochia cymbifera with streptomycin as a potential antibacterial drug
    Willer F Silva, Samyra G Cecílio, Cintia LB Magalhães, Jaqueline MS Ferreira, Antonio H Tótola, Jose C de Magalhaes
    Springerplus, 2013
  • Swim training does not protect mice from skeletal muscle oxidative damage following a maximum exercise test
    Tatiane Oliveira Barreto, Lorena Sabino Cleto, Carolina Rosa Gioda, Renata Sabino Silva, Ana Carolina Campi-Azevedo, Junia de Sousa-Franco, José Carlos de Magalhães, Claudia Lopes Penaforte, Kelerson Mauro de Castro Pinto, Jader dos Santos Cruz, Etel Rocha-Vieira
    European Journal of Applied Physiology, 2012
  • Divergent cytokine response following maximum progressive swimming in hot water
    Ana Carolina Campi‐Azevedo, Lorena Sabino Cleto, Renata Sabino da Silva, Junia de Sousa‐Franco, José Carlos de Magalhães, Claudia Lopes Penaforte, Kelerson Mauro de Castro Pinto, Etel Rocha‐Vieira
    Cell Biochemistry and Function, 2011
  • Identification of a phylogenetically distinct orthobunyavirus from group C
    Cintia Lopes de Brito Magalhães, Betânia Paiva Drumond, Renata Franco Vianna Novaes, Bárbara Rezende Quinan, José Carlos de Magalhães, João Rodrigues dos Santos, Carla do Amaral Pinto, Marieta Torres de Abreu Assis, Cláudio Antônio Bonjardim, Erna Geessien Kroon, Paulo César Peregrino Ferreira
    Archives of Virology, 2011
  • Differential role played by the MEK/ERK/EGR-1 pathway in orthopoxviruses vaccinia and cowpox biology
    Patrícia N. G. Silva, Jamária A. P. Soares, Bruno S. A. F. Brasil, Sarah V. Nogueira, Anderson A. Andrade, José C. de Magalhães, Marisa B. Bonjardim, Paulo C. P. Ferreira, Erna G. Kroon, Oscar Bruna-Romero, Cláudio A. Bonjardim
    Biochemical Journal, 2006
  • A mitogenic signal triggered at an early stage of vaccinia virus infection. Implication of MEK/ERK and protein kinase A in virus multiplication
    José C. de Magalhães, Anderson A. Andrade, Patrícia N.G. Silva, Lirlândia P. Sousa, Catherine Ropert, Paulo C.P. Ferreira, Erna G. Kroon, Ricardo T. Gazzinelli, Cláudio A. Bonjardim
    Journal of Biological Chemistry, 2001

RECENT SCHOLAR PUBLICATIONS

  • Energy Generation and Storage
    D Esteves, L Truta, J Magalhães, L Sousa, D Campanhã, C Furtado, ...
    Sustainable, Innovative, and Intelligent Industries and Societies, 385-422 , 2026
    2026
  • Silymarin Attenuates Arthritis and Myositis in a Murine Model of Acute Infection by Chikungunya and Mayaro Viruses
    RLS Lima, A Coelho Ferraz, M Bueno da Silva Menegatto, ...
    ACS Infectious Diseases , 2026
    2026
  • Religião, economia e exploração espacial: pilares da nova ordem mundial
    JC de Magalhães
    Almedina Brasil , 2025
    2025
  • Vaccinia virus modulates the redox environment by inhibiting reactive oxygen and nitrogen species with increased activity of endogenous antioxidant enzymes
    MB da Silva Menegatto, AC Ferraz, RLS Lima, PH Guimarães, ...
    Scientific Reports 15 (1), 29771 , 2025
    2025
    Citations: 2
  • Silymarin exerts antioxidant and antiviral effects on Zika virus infection
    RLS Lima, MB da Silva Menegatto, LT Almeida, JC de Magalhães, ...
    Journal of Virological Methods 335, 115133 , 2025
    2025
    Citations: 5
  • Activity of extracts and terpenoids from Tontelea micrantha (Mart. ex Schult.) A.C.Sm. (Celastraceae) against pathogenic bacteria
    RP Lopes, FL Ferreira, G Faria de Sousa, WS Cruz Nizer, ...
    Natural Product Research 39 (10), 2724-2733 , 2025
    2025
    Citations: 1
  • Flavonoids and Triterpenoids Isolated From the Ethyl Acetate Extract of M. quadrangulata Leaves
    MG de Aguilar, S Verissimo Morais Quintao, KC Camargo, L Pains Duarte, ...
    Chemistry & Biodiversity 21 (7), e202400636 , 2024
    2024
    Citations: 4
  • Yellow fever virus infection in human hepatocyte cells triggers an imbalance in redox homeostasis with increased reactive oxygen species production, oxidative stress, and …
    AC Ferraz, MB da Silva Menegatto, RLS Lima, OS Ola-Olub, DC Costa, ...
    Free Radical Biology and Medicine 213, 266-273 , 2024
    2024
    Citations: 23
  • Exploring the antiviral potential of justicidin B and four glycosylated lignans from Phyllanthus brasiliensis against Zika virus: A promising pharmacological approach
    AC Ferraz, PWP Gomes, MB da Silva Menegatto, RLS Lima, ...
    Phytomedicine 123, 155197 , 2024
    2024
    Citations: 11
  • Untargeted‐based metabolomics analysis and in vitro/in silico antiviral activity of extracts from Phyllanthus brasiliensis (Aubl.) Poir
    ARV Carvalho, JDE Reis, PWP Gomes, AC Ferraz, HA Mardegan, ...
    Phytochemical Analysis 34 (7), 869-883 , 2023
    2023
    Citations: 7
  • Virucidal antiviral activity of Maytenus quadrangulata extract against Mayaro virus: Evidence for the presence of catechins
    DA de Fátima Nunes, GFM Lopes, WS da Cruz Nizer, MG de Aguilar, ...
    Journal of Ethnopharmacology 311, 116436 , 2023
    2023
    Citations: 8
  • Cytotoxicity, structural, conformational, and techno‐functional properties of α‐lactalbumin nanostructured aggregates
    JRO Bianchi, BER Paz, LG Fonseca, RL Carvalho, JC Magalhães, ...
    Journal of Food Science 88 (7), 3049-3062 , 2023
    2023
    Citations: 5
  • Oropouche virus infection induces ROS production and oxidative stress in liver and spleen of mice
    MB da Silva Menegatto, AC Ferraz, RLS Lima, LT Almeida, RCF de Brito, ...
    Journal of General Virology 104 (5), 001857 , 2023
    2023
    Citations: 29
  • Chemical Diversity and In Vitro/In Silico Antiviral Activity of Extracts from Different Parts of Phyllanthus brasiliensis (Aubl.) Poir
    ARV Carvalho, JDE Reis, PWP Gomes, AC Ferraz, HA Mardegan, ...
    2023
  • Anti-Mayaro virus activity of a hydroethanolic extract from Fridericia chica (Bonpl.) LG Lohmann leaves
    GFM Lopes, WG Lima, FRS Santos, DAF Nunes, MJF Passos, ...
    Journal of ethnopharmacology 299, 115685 , 2022
    2022
    Citations: 6
  • Netzahualcoyonol from Salacia multiflora (Lam.) DC. (Celastraceae) roots as a bioactive compound against gram-positive pathogens
    WS da Cruz Nizer, AC Ferraz, TFS Moraes, WG Lima, JP Dos Santos, ...
    Natural Product Research 36 (22), 5904-5909 , 2022
    2022
    Citations: 5
  • NS2B‐NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review
    DAF Nunes, FRS Santos, STD da Fonseca, WG de Lima, WSC Nizer, ...
    Journal of Medical Virology 94 (2), 442-453 , 2022
    2022
    Citations: 37
  • A methanol extract and N,N-dimethyltryptamine from Psychotria viridis Ruiz & Pav. inhibit Zika virus infection in vitro
    TFS Moraes, AC Ferraz, WS da Cruz Nizer, AH Tótola, DBS Soares, ...
    Archives of virology 166 (12), 3275-3287 , 2021
    2021
    Citations: 11
  • Hepatoprotective, antioxidant, anti-inflammatory, and antiviral activities of silymarin against mayaro virus infection
    AC Ferraz, LT Almeida, CC da Silva Caetano, MB da Silva Menegatto, ...
    Antiviral research 194, 105168 , 2021
    2021
    Citations: 53
  • Bauhinia holophylla (Bong.) Steud. leaves-derived extracts as potent anti-dengue serotype 2
    M Dos Santos, TR Teixeira, FRS Santos, WG Lima, AC Ferraz, NL Silva, ...
    Natural product research 35 (16), 2804-2809 , 2021
    2021
    Citations: 12

MOST CITED SCHOLAR PUBLICATIONS

  • Antibacterial and antifungal activities of phenolic compound-enriched ethyl acetate fraction from Cochlospermum regium (mart. Et. Schr.) Pilger roots: Mechanisms of action and …
    RS Carvalho, CA Carollo, JC De Magalhães, JMC Palumbo, AG Boaretto, ...
    South African Journal of Botany 114, 181-187 , 2018
    2018
    Citations: 152
  • A mitogenic signal triggered at an early stage of vaccinia virus infection: implication of MEK/ERK and protein kinase A in virus multiplication
    JC de Magalhaes, AA Andrade, PNG Silva, LP Sousa, C Ropert, ...
    Journal of Biological Chemistry 276 (42), 38353-38360 , 2001
    2001
    Citations: 131
  • Phytotherapy: an introduction to its history, use and application
    TS Ferreira, CZ Moreira, NZ Caria, G Vitoriano, WF Silva Jr, ...
    Revista Brasileira de Plantas Medicinais 16 (FERREIRA, T.S.; MAGALHÃES, J.C … , 2014
    2014
    Citations: 106
  • Antiviral activity of silymarin against Mayaro virus and protective effect in virus-induced oxidative stress
    FC Camini, TF da Silva, CC da Silva Caetano, LT Almeida, AC Ferraz, ...
    Antiviral research 158, 8-12 , 2018
    2018
    Citations: 83
  • Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo
    LT Almeida, AC Ferraz, CC da Silva Caetano, MB da Silva Menegatto, ...
    Virus research 286, 198084 , 2020
    2020
    Citations: 66
  • Oxidative stress in Mayaro virus infection
    FC Camini, CC da Silva Caetano, LT Almeida, JF da Costa Guerra, ...
    Virus research 236, 1-8 , 2017
    2017
    Citations: 64
  • Detection of the antiviral activity of epicatechin isolated from Salacia crassifolia (Celastraceae) against Mayaro virus based on protein C homology modelling and …
    PG Ferreira, AC Ferraz, JE Figueiredo, CF Lima, VG Rodrigues, ...
    Archives of virology 163 (6), 1567-1576 , 2018
    2018
    Citations: 63
  • Hepatoprotective, antioxidant, anti-inflammatory, and antiviral activities of silymarin against mayaro virus infection
    AC Ferraz, LT Almeida, CC da Silva Caetano, MB da Silva Menegatto, ...
    Antiviral research 194, 105168 , 2021
    2021
    Citations: 53
  • Virucidal activity of proanthocyanidin against Mayaro virus
    AC Ferraz, TFS Moraes, WS da Cruz Nizer, M Dos Santos, AH Tótola, ...
    Antiviral research 168, 76-81 , 2019
    2019
    Citations: 49
  • Desempenho do salto vertical sob diferentes condições de execução
    KR da Silva, J Magalhães, MAC Garcia
    Arquivos em Movimento 1 (1), 17-24 , 2005
    2005
    Citations: 46
  • Differential role played by the MEK/ERK/EGR-1 pathway in orthopoxviruses vaccinia and cowpox biology
    PNG Silva, JAP Soares, BSAF Brasil, SV Nogueira, AA Andrade, ...
    Biochemical Journal 398 (1), 83-95 , 2006
    2006
    Citations: 44
  • NS2B‐NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review
    DAF Nunes, FRS Santos, STD da Fonseca, WG de Lima, WSC Nizer, ...
    Journal of Medical Virology 94 (2), 442-453 , 2022
    2022
    Citations: 37
  • Dengue virus detection in Aedes aegypti larvae from southeastern Brazil
    SG Cecilio, WF da Silva Jr, AH Tótola, CL de Brito Magalhães, ...
    JOURNAL OF VECTOR ECOLOGY 40, 71-74 , 2015
    2015
    Citations: 32
  • Pristimerin isolated from Salacia crassifolia (Mart. Ex. Schult.) G. Don.(Celastraceae) roots as a potential antibacterial agent against Staphylococcus aureus
    WS da Cruz Nizer, AC Ferraz, TFS Moraes, WG Lima, JP Dos Santos, ...
    Journal of Ethnopharmacology 266, 113423 , 2021
    2021
    Citations: 30
  • Oropouche virus infection induces ROS production and oxidative stress in liver and spleen of mice
    MB da Silva Menegatto, AC Ferraz, RLS Lima, LT Almeida, RCF de Brito, ...
    Journal of General Virology 104 (5), 001857 , 2023
    2023
    Citations: 29
  • Swim training does not protect mice from skeletal muscle oxidative damage following a maximum exercise test
    TO Barreto, LS Cleto, CR Gioda, RS Silva, AC Campi-Azevedo, ...
    European Journal of Applied Physiology (Print) 111, 2523-2530 , 2011
    2011
    Citations: 27
  • Antiviral effect of silymarin against Zika virus in vitro
    TF da Silva, AC Ferraz, LT Almeida, CC da Silva Caetano, FC Camini, ...
    Acta tropica 211, 105613 , 2020
    2020
    Citations: 24
  • Plasma cytokine response, lipid peroxidation and NF-kB activation in skeletal muscle following maximum progressive swimming
    LS Cleto, AF Oleto, LP Sousa, TO Barreto, JS Cruz, CL Penaforte, ...
    Brazilian Journal of Medical and Biological Research on line 44, 546-552 , 2011
    2011
    Citations: 24
  • Yellow fever virus infection in human hepatocyte cells triggers an imbalance in redox homeostasis with increased reactive oxygen species production, oxidative stress, and …
    AC Ferraz, MB da Silva Menegatto, RLS Lima, OS Ola-Olub, DC Costa, ...
    Free Radical Biology and Medicine 213, 266-273 , 2024
    2024
    Citations: 23
  • Mayaro virus induction of oxidative stress is associated with liver pathology in a non-lethal mouse model
    CC da Silva Caetano, FC Camini, LT Almeida, AC Ferraz, TF da Silva, ...
    Scientific reports 9 (1), 15289 , 2019
    2019
    Citations: 22