Janneke Zinkstok

Scopus Publications

Labour of Love: A Sequential Exploratory Mixed-Methods Study on the Impact of Caring for a Child With Dravet Syndrome
Amber Postma, Megan Milota, Marian J. Jongmans, Eva H. Brilstra, Janneke R. Zinkstok
Journal of Intellectual Disability Research, 2026
Background Dravet syndrome (DS) is a rare genetic epilepsy syndrome, characterized by refractory seizures, delayed development, intellectual disability and behavioural difficulties. Caring for a child with DS can negatively affect parents' mental well‐being. Therefore, this study aimed to (1) explore experiences of parents caring for a child with DS; and (2) assess distress and empowerment in these parents and the interplay between these aspects. Methods We used a sequential exploratory mixed‐method design. We conducted focus groups with parents of children/adults with DS, analysed these data through iterative coding to identify themes and used the Distress Thermometer for parents (DT‐P) and the Dutch Family Empowerment Scale (FES) for quantitative measures. Results were validated in a final focus group. Results Twenty parents participated in focus groups and 65 completed questionnaires. Four themes emerged: handling the unpredictable behaviour of a child with DS, attending to one's mental health needs and well‐being, adjusting life and accepting changes to meet the child's needs and struggles navigating the (health)care system. Quantitative analyses showed a significant correlation between higher parental empowerment and lower distress, and more behavioural difficulties in their child with DS and higher parental distress. Conclusions Parental distress is high, especially for those parenting a child with DS and behavioural difficulties. Effective management of these issues and enhancing empowerment can improve overall family well‐being.
“No Words Needed”: Results of a Survey on How Parents of Children With Neurodevelopmental Disorders Perceive (In)formal Peer Support
Monica Verkooijen, Marjolijn Ketelaar, Leonie te Grefte, Indira Tendolkar, Wouter Staal, Janneke Zinkstok
Child Care Health and Development, 2026
Background Parents caring for children with neurodevelopmental disorders (NDD) face unique and ongoing challenges that impact family well‐being. Peer support from individuals with shared lived experiences can offer recognition, shared understanding and empowerment. Despite its promise, peer support for parents of children with NDD remains largely informal, under‐researched and poorly integrated within standard healthcare, limiting its potential accessibility and impact. Little is known about what parents seek in peer support, how they experience it, and which factors facilitate meaningful engagement. This study therefore aimed to explore parents' perceptions of peer support, focusing on uptake, impact and conditions influencing its effectiveness. Methods A survey co‐created with parent–carers collected quantitative and qualitative data on perceptions, needs, concerns and barriers related to peer support. The online survey was distributed via parent organisations. Descriptive statistics summarised participant characteristics and peer support uptake, while thematic analysis identified key experiential themes from open‐ended responses. Results Among the 225 participating parents (89% mothers), 77.3% expressed a need for peer support, mostly because friends and family did not fully understand their situation. Of these parents, 65.6% reported finding peer support, mostly informal initiatives. Thematic analysis of participants' comments revealed four key categories describing the experience with and need for peer support: (1) support, (2) mutual learning, (3) connection by recognition and (4) experiencing no judgement. Also included in the results are concerns reported by parents and factors facilitating or hindering successful peer support. Conclusion Parents of children with NDD valued peer support for emotional connection, practical advice and shared understanding. Preferences are highly individual, emphasising the need for tailored peer support. These findings may guide the design and implementation of peer support initiatives aligned with parents' needs and preferences. Future research should focus on how the full potential of peer support for these parents can be unlocked.
Young people requesting medical aid in dying on the basis of psychiatric suffering: 'Not now' as a guiding principle
Tijdschrift Voor Psychiatrie, 2026
Impact of peer-support programs for individuals with autism: A systematic review
Monica HM Verkooijen, Marjolijn Ketelaar, Max van Woerden, Wouter G Staal, Indira Tendolkar, Janneke R Zinkstok
Autism, 2026
The neurodiversity approach recognizes autism as a natural variation of human experience, emphasizing unique strengths while acknowledging social and behavioral challenges that may affect quality of life. Peer support, based on shared experiences and mutual understanding, has shown benefits in mental health care, yet its impact for autistic individuals remains underexplored. This review is of peer-support programs for individuals with autism, focusing on impact, facilitators, and barriers. A systematic literature review was conducted using Cochrane Library, Web of Science, PubMed, Embase, PsycINFO, and Sociological Abstracts. Studies involving peer-support programs for autistic individuals aged 12 and older were selected. Fifteen articles described 12 unique peer-support programs with varying goals, such as enhancing personal development. Studies reported diverse improvements, including enhanced well-being, self-esteem, and academic performance. Many participants valued connecting with peers in an autism-focused context. Most articles discussed some facilitators and barriers. Peer support shows promising benefits for autistic individuals, fostering empowerment and well-being. However, the methodological limitations of the included studies, such as small sample sizes and lack of control groups, limit the strength of these conclusions. Future research should therefore use more robust research methods and investigate accessibility and potential risks to optimize peer support for this population. Lay Abstract Connecting through peer support: Understanding the impact of peer-support programs on individuals with autism and exploring barriers and facilitators. Aim and Purpose of the Research: This study aims to explore the impact of peer-support programs for autistic individuals. Peer support is defined as a supportive relationship between people with shared lived experiences. This review examines the impact of these programs on autistic individuals and identifies key challenges and facilitators that may influence outcomes. Background: Autism, characterized by differences in social interaction and behavior, can affect many aspects of daily life, including social and academic functioning, which can lead to a reduced quality of life. While peer support has proven beneficial in general healthcare, its potential for autistic individuals remains underexplored. Peer-support programs may offer mutual understanding and emotional support, making them a promising approach to improving well-being for people with autism. Methods: A systematic review was conducted using multiple databases to identify research articles published up to January 17, 2024. Studies included focused on peer-support programs for autistic individuals aged 12 and older, employing methods such as interviews or questionnaires to assess their impact. Results and Importance: The findings indicate that peer-support programs generally have a positive impact, including improved self-esteem, academic performance, and overall well-being. Participants valued the opportunity to connect with others with similar experiences. Although the findings are promising, most studies were small and low quality, so more research is needed. Future research should also investigate the factors contributing to successful peer support and explore ways to optimize these programs for autistic individuals.
Efficacy of glutamate-GABA modulator riluzole for the treatment of cognitive and psychotic symptoms in 22q11.2 deletion syndrome: A placebo-controlled crossover trial
Amy L Sylvester, Jeltje CC Spapens, Nele Soons, Sophie Kappert, Paddy Janssen, Dimo Ivanov, Janneke R Zinkstok, David EJ Linden, Thérèse van Amelsvoort, Claudia Vingerhoets
Psychiatry Research, 2026
Individuals with 22q11.2 deletion syndrome are susceptible to psychosis and cognitive impairments. These symptoms have been linked to a disruption in the balance of glutamate (excitatory) to GABA (inhibitory) transmission. This clinical trial aimed to determine whether the glutamate and GABA-modulating drug riluzole reduces psychotic or cognitive symptoms within 22q11.2 deletion syndrome. 32 participants with a 22q11.2 deletion and psychotic and/or cognitive symptoms were enrolled in this placebo-controlled, fixed-order crossover trial. Participants received placebo for 8 weeks, followed by 8 weeks of 100mg/day riluzole. The Positive and Negative Syndrome Scale (PANSS) and Pennsylvania Computerized Neurocognitive Battery (CNB) were used to assess psychotic and cognitive symptoms, with PANSS total and subscale scores and CNB accuracy and reaction time as primary outcome measures. Correcting for family-wise error rate, riluzole improved performance on executive function (p = 0.036), social cognition (p = 0.041), and non-verbal reasoning (p = 0.005) tasks in comparison to baseline. Following correction, no significant effects of riluzole were found on the PANSS total score and subscales, or on accuracy and reaction time on the CNB compared to placebo. Exploratory analyses of individual PANSS items indicated that riluzole reduced anxiety (p = 0.001) and impairments in abstract thinking (p = 0.039) compared to baseline. Our results suggest riluzole may have beneficial effects on mental health and cognition. Further research is needed to confirm these findings and establish a responsive phenotype.
Equitable Collaboration Between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research
Brenda Cabrera‐Mendoza, Margit Burmeister, Marcella Rietschel, David Crepaz‐Keay, Yatan Pal Singh Balhara, Soraya Seedat, Victoria Marshe, Sian Hemmings, Roseann Peterson, Ruchika Kaushik, Biju Viswanath, Reeteka Sud, Partha Haldar, Mandy Johnstone, Anish V. Cherian, Todd Lencz, Janneke Zinkstok, Renato Polimanti, Daniel J. Mueller, Gabriel Lázaro‐Muñoz, Chunyu Liu, Nurnberger John, Humberto Nicolini, Consuelo Walss‐Bass, Marcos Santoro, Sujata Satapathy, Chittaranjan Behera, Anna R. Docherty
American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 2025
International collaborations between high‐income countries (HICs) and low‐ and middle‐income countries (LMICs) have become increasingly essential in advancing global health, particularly within psychiatric research. These partnerships not only accelerate scientific discovery and enhance public health, but they also bring to light significant challenges in equity and fairness. Specifically, research partnerships often suffer from imbalances, such as “helicopter” research approaches or the exploitation and marginalization of LMIC researchers. Here, we present a consensus report by members of the International Society for Psychiatric Genetics, outlining key considerations and strategies for planning, implementing, and disseminating equitable collaborative research. Throughout the collaboration process, we identified both challenges and opportunities and provided recommendations to maximize the benefits of these partnerships. Among our considerations, we emphasize that Equitable Collaboration must begin with comprehensive stakeholder engagement, fostering a participatory environment that includes local communities, governments, and institutions from both HICs and LMICs. Among the potential challenges we identify are differences in ethical research and data‐sharing frameworks across countries, inequalities in research resources and infrastructure, and reduced visibility of research conducted in LMICs. These factors can significantly impact research outcomes and their applicability. In conclusion, while global collaboration in psychiatric genetics presents complex challenges, it also offers substantial opportunities for impactful research and improved global mental health.
Mental health changes during and after the COVID-19 pandemic in children and adolescents with mental disorders
Josjan Zijlmans, Lotte van Rijn, Hekmat Alrouh, Emma Broek, Michiel Luijten, Jacintha Tieskens, Malindi van der Mheen, Hedy van Oers, Wiepke Cahn, Arnt Schellekens, , J.K. Bird, J.K. Buitelaar, Y. de Vries, T.J. Dekkers, Y. Haveman, I. Hein, P.J. Hoekstra, H. Klip, R.J.L. Lindauer, M. Luman, M.H. Nauta, L.M.C. Jansen, L. Nijland, S. Pieters, A. Popma, W. Staal, D. van Doelen, R.R.J.M. Vermeiren, I. Visser, M. Wildschut, Tinca J. C. Polderman, Janneke R. Zinkstok
European Child and Adolescent Psychiatry, 2025
The COVID-19 pandemic negatively affected child and adolescent mental health, but it is unclear which subgroups were affected most. We investigated to what extent severity and type of mental health problems during and after the pandemic were related to preexisting mental disorders in children in care at child and adolescent mental health services. We employed a repeated cross-sectional design involving data collection at seven time points (April 2020 to April 2023) in a total sample of 2,545 children (age 8–18 years). We grouped diagnostic classifications in four categories: Autism, ADHD, Anxious/Depressive disorders, and ‘Other’. Mental health was assessed with parent‐reported data on internalizing and externalizing problems and with self‐reported data from the standardized PROMIS questionnaires ‘Anxiety’, ‘Depressive symptoms’, ‘Sleep‐related impairments’, ‘Anger’, ‘Global health’, and ‘Peer relations’. We tested for main effects between diagnostic categories and for different trajectories over time. We found that mental health outcomes varied substantially between diagnostic categories, with internalizing problems being largest in children with Anxious/Depressive disorders, and externalizing problems being largest in children with Autism and ADHD. However, we found no evidence for differences between diagnostic categories in trajectories in mental health outcomes during and after the COVID-19 pandemic. The results show that during the pandemic mental health outcomes worsened over time in children and adolescents in care, and that this negative effect on mental health did not differ between children with different diagnostic classifications. Regular high-quality monitoring is vital to recognize changing trajectories of youth mental health and to adapt to crisis situations.
The impact of the COVID-19 pandemic on mental and psychosocial functioning, quality of life, and recovery in adults with severe mental illness: Findings from Dutch longitudinal cohorts
Lotte van Rijn, Wilma E. Swildens, Margot J. Metz, Daphne Everaerd, Tinca Polderman, Wiepke Cahn, Arnt F.A. Schellekens, Josjan Zijlmans, Janneke R. Zinkstok
European Psychiatry, 2025
Background The coronavirus disease 2019 (COVID-19) pandemic has impacted global mental health, with individuals with severe mental illness (SMI) being particularly vulnerable. Research on changes in psychiatric symptoms during this pandemic has yielded inconsistent results, often due to individual heterogeneity and a limited focus on broader outcomes such as psychosocial functioning, societal and personal recovery, and quality of life (QoL). Furthermore, long-term effects remain underexplored. This longitudinal cohort study aimed to assess the COVID-19 pandemic’s impact on mental and psychosocial functioning, QoL, and recovery in individuals with SMI, and to explore individual and treatment characteristics associated with outcome changes. Methods Two cohorts were included, involving adults (≥18 years) diagnosed with DSM-5 disorders and experiencing long-term impairments. Participants received care between January 1, 2018 and December 31, 2023. Outcomes included the Health of the Nation Outcome Scales, the Manchester Short Assessment of Quality of Life, and the Individual Recovery Outcomes Counter. Changes were analyzed across five pandemic periods using linear mixed models. Results Improvements in mental and psychosocial functioning, QoL, and recovery were observed over time, regardless of the COVID-19 pandemic period. However, progress was slower during the COVID-19 pandemic compared to pre-pandemic levels. No individual or treatment characteristics were significantly linked to changes in outcomes. Conclusion The findings suggest that the COVID-19 pandemic had a minimal negative impact on individuals with SMI. This may be due to the marginal negative effects of the pandemic on this population, or the mitigating role of stabilizing factors within the current Dutch care models.
Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study
Jet B. Muskens, Wietske A. Ester, Helen Klip, Janneke Zinkstok, Martine van Dongen-Boomsma, Wouter G. Staal
Child Psychiatry and Human Development, 2025
Many children with psychiatric disorders display somatic symptoms, although these are frequently overlooked. As somatic morbidity early in life negatively influences long-term outcomes, it is relevant to assess comorbidity. However, studies of simultaneous psychiatric and somatic assessment in children are lacking. The aim of this study was to assess the prevalence of somatic comorbidities in a clinical sample of children and adolescents with psychiatric disorders in a naturalistic design. Data were assessed from 276 children with various psychiatric disorders (neurodevelopmental disorders, affective disorders, eating disorders and psychosis) aged 6–18 years. These data were collected as part of routine clinical assessment, including physical examination and retrospectively analyzed. For a subsample (n = 97), blood testing on vitamin D3, lipid spectrum, glucose and prolactin was available. Results of this cross-sectional study revealed that food intake problems (43%) and insomnia (66%) were common. On physical examination, 20% of the children were overweight, 12% displayed obesity and 38% had minor physical anomalies. Blood testing (n = 97) highlighted vitamin D3 deficiency (< 50 nmol/L) in 73% of the children. None of the predefined variables (gender, age, medication and socioeconomic factors) contributed significantly to the prevalence of somatic comorbidities. The main somatic comorbidities in this broad child- and adolescent psychiatric population consisted of (1) problems associated with food intake, including obesity and vitamin D3 deficiency and (2) sleeping problems, mainly insomnia. Child and adolescent psychiatrists need to be aware of potential somatic comorbidities and may promote a healthy lifestyle.
Fluctuations in dispensed out-patient psychotropic medication prescriptions during the COVID-19 pandemic in The Netherlands
Damian A. Visser, Daphne S. Everaerd, Hannah Ellerbroek, Janneke R. Zinkstok, Indira Tendolkar, Femke Atsma, Arnt F. A. Schellekens
Bjpsych Open, 2025
Background The COVID-19 pandemic and lockdowns had a significant impact on mental well-being and (mental) healthcare systems globally. Aims To describe trends and dynamics of out-patient prescribing of psychotropic medications during the COVID-19 pandemic in The Netherlands. Method Dispensed psychotropic medication prescriptions during the COVID-19 pandemic from March 2020 to March 2022 were retrieved from national registry data. Numbers of total and incident dispensed prescriptions and defined daily doses (DDDs) were identified for six medication groups. Overall pandemic-related changes in prescribing trends were analysed using interrupted time-series analyses. Lockdown-related prescribing dynamics were described using monthly risk ratios. Results No overall pandemic-related changes in prescribing were detected, except for alcohol addiction medication, for which a pre-pandemic decline in total dispensed prescriptions and DDDs levelled off during the pandemic: +10 prescriptions per week (95% CI 7–11, P ≤ 0.001) and +111 DDDs per week (95% CI 56–165, P = 0.001). Monthly prescribing dynamics showed transient increases in all medication groups during the second and third lockdown periods. There were decreases in dispensed incident antidepressant and opioid addiction medication prescriptions during the first lockdown (average risk ratios: 0.87 and 0.88 respectively), and DDDs of dispensed incident and total attention-deficit hyperactivity disorder medication prescriptions and incident benzodiazepine prescriptions were elevated from the end of the second lockdown (average risk ratios: 1.40, 1.12 and 1.17, respectively). Conclusions These findings raise concerns regarding possible over- and under-prescribing during the pandemic. Further understanding of specific factors driving these changes is necessary to help prepare for future mental health(care) challenges.
A comprehensive overview of neuropsychiatric symptoms in adolescents with 22q11.2 deletion syndrome
I. Selten, J. Blok, T. Boerma, A. A. A. M. J. Djelantik, M. Houben, F. Wijnen, J. Zinkstok, J. A. S. Vorstman, A. M. Fiksinski
Journal of Intellectual Disability Research, 2025
Concerns about genetic risk testing for opioid use disorder
Alexander S Hatoum, Christal N Davis, Rachel L Kember, Mandy Johnstone, David W Oslin, Janneke R Zinkstok, Margit Burmeister, Arpana Agrawal, Henry R Kranzler, Howard J Edenberg, Joel Gelernter, Anna R Docherty, Todd Lencz
Lancet Psychiatry, 2025
Effectiveness of mindfulness-based cognitive therapy for adults with autism
Imke Hanssen, Anne Speckens, Janneke Zinkstok
Gedragstherapie Tijdschrift Voor Gedragstherapie En Cognitieve Therapie, 2025
Later is too late: Why psychiatrists must take action today for patients and the climate
Tijdschrift Voor Psychiatrie, 2025
What do European clinical guidelines say about genetic testing for people with neuropsychiatric disorders? A scoping review
Izemnur Arican, Marte van der Horst, Nicholas Bass, Janneke R. Zinkstok
Psychiatric Genetics, 2025
Cracks in the glass ceiling: An increase in female professors in psychiatry
Tijdschrift Voor Psychiatrie, 2025
Exploring community perspectives on autism genetics research: Indications of supportive views and educational needs
Melanie M de Wit, Janneke R Zinkstok, Riley Buijsman, Abdel Abdellaoui, Sander Begeer, Tinca JC Polderman
Autism, 2025
Exploring individual parent-to-parent support interventions for parents caring for children with brain-based developmental disabilities: A scoping review
Amber Postma, Marjolijn Ketelaar, Justus van Nispen tot Sevenaer, Zahra Downs, Diane van Rappard, Marian Jongmans, Janneke Zinkstok
Child Care Health and Development, 2024
Understanding neurodevelopmental trajectories and behavioral profiles in SCN1A-related epilepsy syndromes
Amber Postma, Crista A. Minderhoud, Wim M. Otte, Floor E. Jansen, W.B. Gunning, Judith S. Verhoeven, Marian J. Jongmans, Janneke R. Zinkstok, Eva H. Brilstra
Epilepsy and Behavior, 2024
The ethics of polygenic scores in psychiatry: Minefield or opportunity for patient-centered psychiatry?
Roel H.P. Wouters, Marte Z. van der Horst, Cora M. Aalfs, Janita Bralten, Jurjen J. Luykx, Janneke R. Zinkstok
Psychiatric Genetics, 2024
Psychiatric and neurological manifestations in adults with Smith–Magenis syndrome: A scoping review
Dorinde Korteling, Jiska L. I. Musch, Janneke R. Zinkstok, Erik Boot
American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 2024
Teenagers, screens and smartphones: what does science say?
Tijdschrift Voor Psychiatrie, 2024
‘I am proud of how I handled it’. Exploring the impact of the COVID-19 pandemic and related restrictions on well-being of adults with severe mental illness using qualitative methods
L. van Rijn, M. J. Metz, P. R. van der Velden, P. Mathijsen, W. E. Swildens, A. F. A. Schellekens, W. Cahn, M. M. Milota, J. R. Zinkstok
Health Expectations, 2024
Quality of life in SCN1A-related seizure disorders across the lifespan
Crista A Minderhoud, Amber Postma, Floor E Jansen, Janneke R Zinkstok, Judith S Verhoeven, Bianca Berghuis, Wim M Otte, Marian J Jongmans, Kees P J Braun, Eva H Brilstra
Brain Communications, 2024
COVID in a 'psychiatric nursing home': An exploratory research
Tijdschrift Voor Psychiatrie, 2024
Publishing about open cohort and case studies
Tijdschrift Voor Psychiatrie, 2023
Intellectual and Behavioral Phenotypes of Smith–Magenis Syndrome: Comparisons between Individuals with a 17p11.2 Deletion and Pathogenic RAI1 Variant
Cathelijne C. Linders, Agnies M. van Eeghen, Janneke R. Zinkstok, Marie-José van den Boogaard, Erik Boot
Genes, 2023
Challenging behavior in children and adolescents with Dravet syndrome: Exploring the lived experiences of parents
Amber Postma, Megan Milota, Marian J. Jongmans, Eva H. Brilstra, Janneke R. Zinkstok
Epilepsy and Behavior, 2023
Parkinsonism in Genetic Neurodevelopmental Disorders: A Systematic Review
Emma N.M.M. von Scheibler, Agnies M. van Eeghen, Tom J. de Koning, Mark L. Kuijf, Janneke R. Zinkstok, Annelieke R. Müller, Thérèse A.M.J. van Amelsvoort, Erik Boot
Movement Disorders Clinical Practice, 2023
Untargeted metabolic analysis in dried blood spots reveals metabolic signature in 22q11.2 deletion syndrome
Dorinde Korteling, Marco P. Boks, Ania M. Fiksinski, Ilja N. van Hoek, Jacob A. S. Vorstman, Nanda M. Verhoeven-Duif, Judith J. M. Jans, Janneke R. Zinkstok
Translational Psychiatry, 2022
Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians’ attitudes to sociocultural differences between patients across the globe
Justo Pinzón-Espinosa, Marte van der Horst, Janneke Zinkstok, Jehannine Austin, Cora Aalfs, Albert Batalla, Patrick Sullivan, Jacob Vorstman, Jurjen J. Luykx
Translational Psychiatry, 2022
Adults with autism spectrum disorder and the criminal justice system: An investigation of prevalence of contact with the criminal justice system, risk factors and sex differences in a specialist assessment service
Charlotte E Blackmore, Emma L Woodhouse, Nicola Gillan, Ellie Wilson, Karen L Ashwood, Vladimira Stoencheva, Alexandra Nolan, Grainne M McAlonan, Dene M Robertson, Susannah Whitwell, Quinton Deeley, Michael C Craig, Janneke Zinkstok, Rob Wichers, Debbie Spain, Ged Roberts, Declan GM Murphy, Clodagh M Murphy, Eileen Daly
Autism, 2022
A qualitative and quantitative study of self-reported positive characteristics of individuals with ADHD
Lessa M. Schippers, Lisa I. Horstman, Hans van de Velde, Rob Rodrigues Pereira, Janneke Zinkstok, Jeanette C. Mostert, Corina U. Greven, Martine Hoogman
Frontiers in Psychiatry, 2022
Psychiatric symptoms and COVID-19: Results of a national case register
Tijdschrift Voor Psychiatrie, 2022
Vitamin D status in children with a psychiatric diagnosis, autism spectrum disorders, or internalizing disorders
Jet Muskens, Helen Klip, Janneke R. Zinkstok, Martine van Dongen-Boomsma, Wouter G. Staal
Frontiers in Psychiatry, 2022
A person comes to the psychiatrist: towards sex-gender sensitive mental health care
Tijdschrift Voor Psychiatrie, 2022
A normative chart for cognitive development in a genetically selected population
Ania M. Fiksinski, Carrie E. Bearden, Anne S. Bassett, René S. Kahn, Janneke R. Zinkstok, Stephen R. Hooper, Wanda Tempelaar, Donna McDonald-McGinn, Ann Swillen, Beverly Emanuel, Bernice Morrow, Raquel Gur, Eva Chow, Marianne van den Bree, Joris Vermeesch, Stephen Warren, Michael Owen, Therese van Amelsvoort, Stephan Eliez, Doron Gothelf, Celso Arango, Wendy Kates, Tony Simon, Kieran Murphy, Gabriela Repetto, Damian Heine Suner, Stefano Vicari, Joseph Cubells, Marco Armando, Nicole Philip, Linda Campbell, Sixto Garcia-Minaur, Maude Schneider, Vandana Shashi, Jacob Vorstman, Elemi J. Breetvelt, and
Neuropsychopharmacology, 2022
'A revolution is taking place in genetics' - Interview with Danielle Posthuma
Tijdschrift Voor Psychiatrie, 2022
Genetic risk of mental illness: What do we know and how do we communicate this?
Tijdschrift Voor Psychiatrie, 2022
Guidelines on genetic testing in psychiatry: an overview
Tijdschrift Voor Psychiatrie, 2022
Psychiatry and genetics: The long road from laboratory to consulting room
Tijdschrift Voor Psychiatrie, 2022
Genes to Mental Health (G2MH): A Framework to Map the Combined Effects of Rare and Common Variants on Dimensions of Cognition and Psychopathology
Sébastien Jacquemont, Guillaume Huguet, Marieke Klein, Samuel J.R.A. Chawner, Kirsten A. Donald, Marianne B.M. van den Bree, Jonathan Sebat, David H. Ledbetter, John N. Constantino, Rachel K. Earl, Donna M. McDonald-McGinn, Therese van Amelsvoort, Ann Swillen, Anne H. O’Donnell-Luria, David C. Glahn, Laura Almasy, Evan E. Eichler, Stephen W. Scherer, Elise Robinson, Anne S. Bassett, Christa Lese Martin, Brenda Finucane, Jacob A.S. Vorstman, Carrie E. Bearden, Raquel E. Gur, and
American Journal of Psychiatry, 2022
Genetic risk of mental illness: what do we know and how do we communicate this?
Tijdschrift Voor Psychiatrie, 2022
Guidelines on genetic testing in psychiatry: an overview
Tijdschrift Voor Psychiatrie, 2022
Methylphenidate for attention-deficit/hyperactivity disorder in patients with Smith–Magenis syndrome: protocol for a series of N-of-1 trials
A. R. Müller, J. R. Zinkstok, N. N. J. Rommelse, P. M. van de Ven, K. C. B. Roes, F. A. Wijburg, E. de Rooij-Askes, C. Linders, E. Boot, A. M. van Eeghen
Orphanet Journal of Rare Diseases, 2021
Transcriptomic profiling of whole blood in 22q11.2 reciprocal copy number variants reveals that cell proportion highly impacts gene expression
Amy Lin, Jennifer K. Forsyth, Gil D. Hoftman, Leila Kushan-Wells, Maria Jalbrzikowski, Deepika Dokuru, Giovanni Coppola, Ania Fiksinski, Janneke Zinkstok, Jacob Vorstman, Daniel Nachun, Carrie E. Bearden
Brain Behavior and Immunity Health, 2021
Study protocol of a randomized, double-blind, placebo-controlled, multi-center trial to treat antipsychotic-induced weight gain: the Metformin-Lifestyle in antipsychotic users (MELIA) trial
Nini de Boer, Sinan Guloksuz, Caroline van Baal, Leonie Willebrands, Jeroen Deenik, Christiaan H. Vinkers, Inge Winter-van Rossum, Janneke Zinkstok, Ingeborg Wilting, Jasper B. Zantvoord, Frank Backx, Wilma E. Swildens, Marieke Schouw, Jan Bogers, Folkwin Hulshof, Rudolf de Knijff, Peter Duindam, Mike Veereschild, Maarten Bak, Geert Frederix, Lieuwe de Haan, Jim van Os, Wiepke Cahn, Jurjen J. Luykx
BMC Psychiatry, 2021
Psychiatric phenotypes associated with hyperprolinemia: A systematic review
Yasmin Namavar, Denise Joanne Duineveld, Geertje Ingena Angelique Both, Ania Maria Fiksinski, Jacob Abraham Schrey Vorstman, Nanda Margriet Verhoeven‐Duif, Janneke Rozemarijn Zinkstok
American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 2021
The youth has the future? About poverty, brain development and psychiatry
Tijdschrift Voor Psychiatrie, 2021
Neurodevelopmental Trajectories and Psychiatric Morbidity: Lessons Learned From the 22q11.2 Deletion Syndrome
Ania M. Fiksinski, Maude Schneider, Janneke Zinkstok, Danielle Baribeau, Samuel J. R. A. Chawner, Jacob A. S. Vorstman
Current Psychiatry Reports, 2021
Polygenic risk scores for genetic counseling in psychiatry: Lessons learned from other fields of medicine
E. Eeltink, M.Z. van der Horst, J.R. Zinkstok, C.M. Aalfs, J.J. Luykx
Neuroscience and Biobehavioral Reviews, 2021
Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers: A randomized double-blind 7-Tesla pharmacological MRS study
Claudia Vingerhoets, Desmond HY Tse, Mathilde van Oudenaren, Dennis Hernaus, Esther van Duin, Janneke Zinkstok, Johannes G Ramaekers, Jacobus FA Jansen, Grainne McAlonan, Therese van Amelsvoort
Journal of Psychopharmacology, 2020
From genetic findings to clinical practice in psychiatry: How genetics may enable precision psychiatry
Tijdschrift Voor Psychiatrie, 2020
Psychosis and movement disorders in an adolescent with 22q11.2 deletion syndrome
Tijdschrift Voor Psychiatrie, 2020
Course of covid-19 infections and impact on mental health; setting up a national case register
Tijdschrift Voor Psychiatrie, 2020
Atypical chromosome 22q11.2 deletions are complex rearrangements and have different mechanistic origins
Lisanne Vervoort, Wolfram Demaerel, Laura Y Rengifo, Adrian Odrzywolski, Elfi Vergaelen, Matthew S Hestand, Jeroen Breckpot, Koen Devriendt, Ann Swillen, Donna M McDonald-McGinn, Ania M Fiksinski, Janneke R Zinkstok, Bernice E Morrow, Tracy Heung, Jacob A S Vorstman, Anne S Bassett, Eva W C Chow, Vandana Shashi, International 22q11.2 Brain, Behavior Consortium, Joris R Vermeesch
Human Molecular Genetics, 2019
Adverse effects of antipsychotic medication in patients with 22q11.2 deletion syndrome: A systematic review
Janna de Boer, Erik Boot, Lissa van Gils, Therese van Amelsvoort, Janneke Zinkstok
American Journal of Medical Genetics Part A, 2019
Neurobiological perspective of 22q11.2 deletion syndrome
Janneke R Zinkstok, Erik Boot, Anne S Bassett, Noboru Hiroi, Nancy J Butcher, Claudia Vingerhoets, Jacob A S Vorstman, Therese A M J van Amelsvoort
Lancet Psychiatry, 2019
Assessing causal links between metabolic traits, inflammation and schizophrenia: A univariable and multivariable, bidirectional Mendelian-randomization study
Bochao D Lin, Anne Alkema, Triinu Peters, Janneke Zinkstok, Lars Libuda, Johannes Hebebrand, Jochen Antel, Anke Hinney, Wiepke Cahn, Roger Adan, Jurjen J Luykx
International Journal of Epidemiology, 2019
Efficacy and tolerability of riluzole in psychiatric disorders: A systematic review and preliminary meta-analysis
J.N. de Boer, C. Vingerhoets, M. Hirdes, G.M. McAlonan, T.V. Amelsvoort, J.R. Zinkstok
Psychiatry Research, 2019
Practical guidelines for prescribing psychotropic medication to people with intellectual disability
Tijdschrift Voor Psychiatrie, 2019
Psychiatry and low intelligence
Tijdschrift Voor Psychiatrie, 2019
On genetics and future psychiatry
Tijdschrift Voor Psychiatrie, 2018
Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder
L A Ajram, J Horder, M A Mendez, A Galanopoulos, L P Brennan, R H Wichers, D M Robertson, C M Murphy, J Zinkstok, G Ivin, M Heasman, D Meek, M D Tricklebank, G J Barker, D J Lythgoe, R A E Edden, S C Williams, D G M Murphy, G M McAlonan
Translational Psychiatry, 2017
Does sex influence the diagnostic evaluation of autism spectrum disorder in adults?
C Ellie Wilson, Clodagh M Murphy, Grainne McAlonan, Dene M Robertson, Debbie Spain, Hannah Hayward, Emma Woodhouse, P Quinton Deeley, Nicola Gillan, J Chris Ohlsen, Janneke Zinkstok, Vladimira Stoencheva, Jessica Faulkner, Hatice Yildiran, Vaughan Bell, Neil Hammond, Michael C Craig, Declan GM Murphy
Autism, 2016
The mental health of individuals referred for assessment of autism spectrum disorder in adulthood: A clinic report
Ailsa J Russell, Clodagh M Murphy, Ellie Wilson, Nicola Gillan, Cordelia Brown, Dene M Robertson, Michael C Craig, Quinton Deeley, Janneke Zinkstok, Kate Johnston, Grainne M McAlonan, Deborah Spain, Declan GM Murphy
Autism, 2016
White-matter relaxation time and myelin water fraction differences in young adults with autism
S. C. L. Deoni, J. R. Zinkstok, E. Daly, C. Ecker, MRC AIMS Consortium, S. C. R. Williams, D. G. M. Murphy
Psychological Medicine, 2015
DSM-5: Neurodevelopmental disorders
Tijdschrift Voor Psychiatrie, 2014
The NICE guideline on recognition, referral, diagnosis and management of adults on the autism spectrum
C. Ellie Wilson, Ged Roberts, Nicola Gillan, Chris Ohlsen, Dene Robertson, Janneke Zinkstok
Advances in Mental Health and Intellectual Disabilities, 2013
Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an adult autism spectrum disorder diagnostic clinic
C. Ellie Wilson, Nicola Gillan, Deborah Spain, Dene Robertson, Gedeon Roberts, Clodagh M. Murphy, Stefanos Maltezos, Janneke Zinkstok, Katie Johnston, Christina Dardani, Chris Ohlsen, P. Quinton Deeley, Michael Craig, Maria A. Mendez, Francesca Happé, Declan G. M. Murphy
Journal of Autism and Developmental Disorders, 2013
COMT Val158met genotype and striatal D2/3 receptor binding in adults with 22q11 deletion syndrome
Erik Boot, Jan Booij, Janneke R. Zinkstok, Frank Baas, Ann Swillen, Michael J. Owen, Declan G. Murphy, Kieran C. Murphy, Don H. Linszen, Thérèse A. Van Amelsvoort
Synapse, 2011
Dopamine metabolism in adults with 22q11 deletion syndrome, with and without schizophrenia-relationship with COMT Val108/158 Met polymorphism, gender and symptomatology
Erik Boot, Jan Booij, Nico Abeling, Julia Meijer, Fabiana da Silva Alves, Janneke Zinkstok, Frank Baas, Don Linszen, Thérèse van Amelsvoort
Journal of Psychopharmacology, 2011
Striatal D2receptor binding in 22q11 deletion syndrome: An [123 I]IBZM SPECT study
E. Boot, J. Booij, JR Zinkstok, L. de Haan, DH Linszen, F. Baas, TA van Amelsvoort
Journal of Psychopharmacology, 2010
The effect of Ecstasy on memory is moderated by a functional polymorphism in the cathechol-O-methyltransferase (COMT) gene
Thelma Schilt, Maarten W.J. Koeter, Maartje M.L. de Win, Janneke R. Zinkstok, Thérèse A. van Amelsvoort, Ben Schmand, Wim van den Brink
European Neuropsychopharmacology, 2009
AMPT-induced monoamine depletion in humans: Evaluation of two alternative [123I]IBZM SPECT procedures
Erik Boot, Jan Booij, Gregor Hasler, Janneke R. Zinkstok, Lieuwe de Haan, Don H. Linszen, Thérèse A. van Amelsvoort
European Journal of Nuclear Medicine and Molecular Imaging, 2008
Disrupted dopaminergic neurotransmission in 22q11 deletion syndrome
Erik Boot, Jan Booij, Janneke Zinkstok, Nico Abeling, Lieuwe de Haan, Frank Baas, Don Linszen, Thérèse van Amelsvoort
Neuropsychopharmacology, 2008
Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia
J. Zinkstok, N. Schmitz, T. Van Amelsvoort, M. Moeton, F. Baas, D. Linszen
Genes Brain and Behavior, 2008
Catechol-O-methyltransferase gene and obsessive-compulsive symptoms in patients with recent-onset schizophrenia: Preliminary results
Janneke Zinkstok, Lonneke van Nimwegen, Therese van Amelsvoort, Lieuwe de Haan, Maryan Abdulkadir Yusuf, Frank Baas, Don Linszen
Psychiatry Research, 2008
Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome
T. van Amelsvoort, J. Zinkstok, M. Figee, E. Daly, R. Morris, M. J. Owen, K. C. Murphy, L. De Haan, D. H. Linszen, B. Glaser, D. G. M. Murphy
Psychological Medicine, 2008
Association between the DTNBP1 gene and intelligence: A case-control study in young patients with schizophrenia and related disorders and unaffected siblings
Janneke R Zinkstok, Odette de Wilde, Therese AMJ van Amelsvoort, Michael W Tanck, Frank Baas, Don H Linszen
Behavioral and Brain Functions, 2007
ZDHHC8 Single Nucleotide Polymorphism rs175174 is not associated with psychiatric features of the 22q11 Deletion Syndrome or Schizophrenia [1]
Caroline Demily, Solenn Legallic, Jacqueline Bou, Emmanuelle Houy-Durand, Thérèse Van Amelsvoort, Janneke Zinkstok, Sylvie Manouvrier-Hanue, Annick Vogels, Valérie Drouin-Garraud, Nicole Philip, Anne Philippe, Delphine Héron, Pierre Sarda, Michel Petit, Florence Thibaut, Thierry Frébourg, Dominique Campion
Psychiatric Genetics, 2007
Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome
Grégory Raux, Emilie Bumsel, Bernadette Hecketsweiler, Therese van Amelsvoort, Janneke Zinkstok, Sylvie Manouvrier-Hanu, Carole Fantini, Georges-Marie M. Brévière, Gabriella Di Rosa, Giuseppina Pustorino, Annick Vogels, Ann Swillen, Solenn Legallic, Jacqueline Bou, Gaelle Opolczynski, Valérie Drouin-Garraud, Marie Lemarchand, Nicole Philip, Aude Gérard-Desplanches, Michèle Carlier, Anne Philippe, Marie Christine Nolen, Delphine Heron, Pierre Sarda, Didier Lacombe, Cyril Coizet, Yves Alembik, Valérie Layet, Alexandra Afenjar, Didier Hannequin, Caroline Demily, Michel Petit, Florence Thibaut, Thierry Frebourg, Dominique Campion
Human Molecular Genetics, 2007
The COMT val158met polymorphism and brain morphometry in healthy young adults
Janneke Zinkstok, Nicole Schmitz, Therese van Amelsvoort, Maartje de Win, Wim van den Brink, Frank Baas, Don Linszen
Neuroscience Letters, 2006
Neuropsychological profile and neuroimaging in patients with 22q11.2 Deletion Syndrome: A review
Janneke Zinkstok, Thérèse van Amelsvoort
Child Neuropsychology, 2005

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