Pharmacology (medical), Pharmacology, Toxicology and Pharmaceutics, General Pharmacology, Toxicology and Pharmaceutics, Pharmaceutical Science
357
Scopus Publications
15234
Scholar Citations
59
Scholar h-index
265
Scholar i10-index
Scopus Publications
A novel approach for assessing environmental CONTAMINATION: LINKING Ache activity to trace metals in aquatic organisms Filipe Joaquim Gonçalves, Renata Maria da Silva Lucas, Rivelino Martins Cavalcante, Irwin Rose Alencar de Menezes, Francisco Assis Bezerra da Cunha, Henrique Douglas Melo Coutinho, Francisco Alixandre Ávila Rodrigues, Lígia Cláudia Castro de Oliveira Environmental Research, 2026 The enzyme acetylcholinesterase (AChE) is one of the primary biomarkers used in the biomonitoring of aquatic ecosystems. However, traditional colorimetric methods exhibit selectivity limitations in complex matrices, such as mollusk, fish, and amphibian tissues. This study presents a rapid and selective HPLC-UV method for the determination of AChE activity, based on the quantification of the enzymatic conversion of 1-naphthyl acetate to 1-naphthol, using a novel extraction protocol designed to minimize matrix interferences. The method was validated following the ICH (International Council for Harmonisation) guidelines, demonstrating adequate selectivity, linearity, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). We applied the proposed method to biological samples of three aquatic species from different regions with distinct degrees of anthropogenic impact. Field application revealed lower AChE activity in samples from contaminated sites (0.00 to 4.44 AChE units/mL) compared to the control (6.11 AChE units/mL), suggesting that the proposed method is suitable for aquatic contamination monitoring. To further validate our methodology, we determined trace metal concentrations (copper, chromium, nickel, and manganese) in biological samples and investigated the association between metal concentrations and AChE activity. The results revealed a clear association (negative correlation) between acetylcholinesterase enzymatic activity and metal concentrations. Thus, the proposed approach successfully identified that AChE activity decreased in regions most impacted by metals, indicating neurotoxic effects.
Neuropharmacological effects of the crude ethanolic extract from aerial parts of Passiflora cincinnata Mast. (Passifloraceae) and possible mechanisms of action involved Talita Lorena N Goncalves, Gyllyandeson de A. Dalmondes, Irwin R. Alencar de Menezes, Henrique D. Melo Coutinho, Laurent Picot, Raimundo G. de Oliveira Junior, Jullyanna de S. Siqueira Quintans, Lucindo J. Quintans Junior, Jackson R. Guedes da Silva Almeida Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2026 Passiflora cincinnatais traditionally used for the management of anxiety-related disorders; however, experimental evidence supporting its neuropharmacological effects remains limited. The present study evaluated the anxiolytic-and antidepressant-like effects of the crude ethanolic extract (Pc-EtOH) obtained from the aerial parts in mice, as well as explored possible mechanisms involved. Male Swiss mice were treated orally with Pc-EtOH (100, 200, or 400 mg/kg) and submitted to a battery of behavioral tests, including theelevated plus maze, open-field, forced swimming, and tail suspension tests. Pc-EtOH at 100 mg/kg produced significant anxiolytic-and antidepressant-like effects, comparable in magnitude to reference drugs in specific parameters, without inducing motor impairment. In contrast, the highest dose (400 mg/kg) was associated with reduced locomotor activity, suggesting sedative effects. Pharmacological antagonism assays indicated a partial involvement of the GABAergic system. These findings suggest that P. cincinnata exhibits dose-dependent neurobehavioral effects, with a favorable profile at lower doses.
Ximenia americana L. From Popular Use to Anti-Inflammatory Activities: A Comprehensive Review Bruno Anderson F. Silva, Maria Gabriely de Lima Silva, Eduardo S. Silva, Lucas Yure S. Silva, Renata Torres Pessoa, Silvio C. Alves‐Júnior, Jullyana S. S. Quintans, Laurent Picot, Irwin Rose A. Menezes, Lucindo J. Quintans‐Júnior Food Frontiers, 2026 Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders. To review the ethnomedicinal uses, phytochemical profile, and biological‐pharmacological properties of X. americana related to inflammation. This systematic review followed the Cochrane Handbook and preferred reporting items for systematic review and meta‐analysis (PRISMA) guidelines. The research question was whether traditional uses of X. americana are supported by its phytochemical and biological properties in nonclinical studies. Article searches were conducted in Medline, Embase, Web of Science, Scopus, Virtual Health Library, SciELO, and Google Scholar. Two reviewers independently selected eligible studies, extracted data, and assessed risk of bias. Ninety‐six articles met the inclusion criteria: 21 in vivo (521.2%), 16 in vitro (39%), and four with both approaches (9.8%). X. americana is used in folk medicine for treating toothaches, respiratory and gastrointestinal disorders, and general inflammation. Scientific studies support these uses, showing anti‐inflammatory, antinociceptive, gastroprotective, and antioxidant properties. A total of 181 compounds have been identified, including 31 oil and fat compounds, 22 terpenes, 18 flavonoids, three phenolic acids, one alkaloid, one polyphenol, and 105 others. X. americana has validated anti‐inflammatory and gastroprotective potential, supported by its rich phytochemical composition. It represents a promising natural source for identifying novel bioactive molecules for treating inflammatory diseases, with strong potential for pharmaceutical development.
Piper tuberculatum Jacq. essential oil and its impact on the control of Candida spp. and Pichia kudriavzevii: increased efficacy of fluconazole and inhibition of virulence Maria Flaviana Bezerra Morais-Braga, Victor Juno Alencar Fonseca, Joara Nalyda Pereira Carneiro, Antonia Thassya Lucas dos Santos, Maria Audilene de Freitas, Andressa Guilhermino dos Santos, Francildo dos Santos Silva, Elita de Sousa Santos, Débora Lima Sales, José Galberto Martins da Costa, Lariza Leisla Leandro Nascimento, Natália Kelly Gomes de Carvalho, Maria Inácio da Silva, Geane Gabriele de Oliveira Souza, Juliana Moura Mendes Arrua, Lucas Yure Santos da Silva, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade-Pinheiro Journal of Ethnopharmacology, 2026
Mechanisms of Action Involved in the In Vivo Gastroprotective Response of Fruits: A Systematic Review Isabel Sousa Alcântara, Renata Torres Pessoa, Lucas Yure Santos da Silva, Tarcisio Mendes Silva, Isis Oliveira Menezes, Anita Oliveira Brito Pereira Bezerra Martins, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley Food Frontiers, 2026 Gastrointestinal diseases remain a significant global health concern, primarily due to the limitations of current pharmacological treatments, which often come with adverse side effects and high recurrence rates. This situation highlights the urgent need for safer and more effective alternatives. Natural products, particularly fruits, have gained considerable attention as potential gastroprotective agents due to their rich content of bioactive compounds that possess antioxidant, anti‐inflammatory, and cytoprotective properties. This systematic review work includes 48 studies aimed at elucidating the mechanisms of action through which fruits exert gastroprotective effects. The analysis identified several key mechanisms, such as enhancing antioxidant defenses with reduction of oxidative stress, modulating prostaglandin synthesis with suppression of pro‐inflammatory cytokines, increasing nitric oxide (NO) production, activating potassium (K⁺) channels involved in protecting the gastric mucosa from injury, and regulating gastric acid secretion. Among the various fruit species cited, Hylocereus polyrhizus (dragon fruit), Phoenix dactylifera (date fruit), Vaccinium corymbosum (blueberry), Punica granatum (pomegranate), Passiflora edulis (passion fruit), Citrus sinensis (sweet orange), Aegle marmelos (bael), and Aronia melanocarpa (chokeberry) demonstrated relevant gastroprotective efficacy. The evidence suggests that incorporating these fruits into the diet may help prevent gastric damage and manage gastrointestinal disorders. However, while preclinical findings are promising, further well‐designed clinical trials are necessary to validate their therapeutic potential.
Targeting oxidative stress and monoamine imbalance: neuroprotective potential of Cereus jamacaru DC ethanolic extract in a Parkinson disease-like model in Drosophila melanogaster Ricardo Gomes Dos Santos Nunes, Yanka Vitoria de Santana Lira, Jailson Renato de Lima Silva, Adrielle Rodrigues Costa, Irwin Rose Alencar de Menezes, Francisco Leandro Medeiros de Lucena Jales, Carlos Alonso Leite dos Santos, Antonia Eliene Duarte, Luiz Marivando Barros, Thainá dos Santos Dantas, Luiz Alberto Lira Soares, Ivone Antônia de Souza, Dieniffer Espinosa Janner, Frâncelly Marquez de Figueiredo, Gustavo Petri Guerra, Belmira Lara da Silveira Andrade-da-Costa Journal of Toxicology and Environmental Health Part A Current Issues, 2026 Exposure to pesticides is a risk factor for developing Parkinson’s disease (PD). Recently, there has been an increase in research on natural products that can reduce this risk. The cactus Cereus jamacaru DC is found in South America, South Africa, and China. When consumed as food or juice, C. jamacaru exhibits medicinal properties with antitumor and cytoprotective effects on the gastrointestinal tract, kidneys, and heart, which are attributed to its high antioxidant content. However, its potential effect on diseases of the nervous system is unknown. The present study examined whether ethanolic extract from C. jamacaru might serve as a nutraceutical alternative against oxidative damage initiated by the pesticide rotenone using the Drosophila melanogaster model of PD. Initially, toxicological assays were performed with the extract added at 0.01–0.1 mg/g of food over 7 days. Locomotor activity, survival rate, and assays for nitric oxide, free Fe2 +, lipid peroxidation, total thiols, reactive oxygen species levels, cytotoxicity, and dopamine and serotonin levels were assessed. The rotenone-induced mortality rate was similar between sexes and was prevented by C. jamacaru extract at 0.075 mg/g of food. Rotenone-induced modifications in locomotor activity, survival rate, and head dopamine and serotonin levels, as well as biochemical parameters, were reversed by one or both concentrations of extract. Data demonstrated for the first time that ethanolic extract of C. jamacaru exerted systemic and neuroprotective effects against rotenone insults. These findings suggest the need for further pharmacological studies examining C. jamacaru as a potential therapeutic intervention for PD prevention or treatment.
Investigation of Phytol as an Inhibitor of the Efflux Pump (QacA/B) in Staphylococcus aureus: in silico and in vitro Studies José Weverton Almeida-Bezerra, Carlos Alonso Leite dos Santos, Saulo Almeida Menezes, Cícera Datiane de Morais Oliveira-Tintino, Rafael Pereira da Cruz, Adrielle Rodrigues Costa, Janaína Esmeraldo Rocha, Daniel Sampaio Alves, Simone Galdino de Sousa, Ewerton Yago de Sousa Rodrigues, Gabriel Gonçalves Alencar, José Maria Barbosa Filho, Viviane Bezerra da Silva, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, José Thyálisson da Costa Silva, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho Pharmaceutical Research, 2026
Integrated in Vitro, in Vivo, Molecular Docking, and ADMET in Silico Assessment of β-Caryophyllene as a NorA Efflux Pump inhibitor in Resistant Staphylococcus Aureus (MRSA) José Weverton Almeida-Bezerra, José Thyálisson da Costa Silva, Cícera Datiane de Morais Oliveira-Tintino, Adrielle Rodrigues Costa, Viviane Bezerra da Silva, Maria Flaviana Bezerra Morais-Braga, Irwin Rose Alencar de Menezes, Ana Carolina Ferreira Araujo, Lucas Yure Santos da Silva, Daniel Sampaio Alves, Guilherme Fernandes Teixeira, Lucas dos Santos Sa, Janaína Esmeraldo Rocha, Ray Silva de Almeida, Gildênia Alves de Araújo, Ewerton Yago de Sousa Rodrigues, Gabriel Gonçalves Alencar, Simone Galdino de Sousa, Carlos Alonso Leite dos Santos, José Maria Barbosa Filho, Henrique Douglas Melo Coutinho Current Microbiology, 2026
Antibacterial and Antibiotic-Enhancing Activity of 3-Hydroxy-4-methoxycinnamic Acid: Experimental Data and In Silico Predictions José Thyálisson da Costa Silva, Viviane Bezerra da Silva, Guilherme Fernandes Teixeira, Carlos Alonso Leite dos Santos, Antonia Adeublena de Araujo Monteiro, Janaína Esmeraldo Rocha, Ewerton Yago de Sousa Rodrigues, Rafael Pereira da Cruz, Isaac Moura Araújo, Adrielle Rodrigues Costa, Cicera Laura Roque Paulo, Irwin Rose Alencar de Menezes, Maria Flaviana Bezerra Morais‐Braga, José Maria Barbosa‐Filho, Saulo Almeida de Menezes, Henrique Douglas Melo Coutinho, José Weverton Almeida‐Bezerra Chemistryselect, 2025
Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps Isydório Alves Donato, Cristina Rodrigues dos Santos Barbosa, Antonio Henrique Bezerra, Suieny Rodrigues Bezerra, Ray Silva Almeida, Cícera Datiane de Morais Oliveira-Tintino, Isaac Moura Araújo, Ewerton Yago de Sousa Rodrigues, Maria Yasmin Cândido de Oliveira, Francisco Ferdinando Cajazeiras, Jayza Maria Lima Dias, Jesyka Macedo Guedes, Jéssica Híade Silva Cristino, Emmanuel Silva Marinho, Márcia Machado Marinho, Hélcio Silva dos Santos, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Francisco Assis Bezerra da Cunha Pharmaceuticals, 2025
Antiparasitic activity and cytotoxic potential of the hydroethanolic extract the leaves of Tocoyena formosa Francisco Rafael Alves Santana Cesário, Thaís Rodrigues de Albuquerque, Giovana Mendes de Lacerda, Maria Neyze Martins Fernandes, Maria Rayane Correia de Oliveira, Anita Oliveira Brito Pereira Bezerr Martins, Miriam Rolón, Maria Celeste Vega Gomez, Antonieta Rojas de Arias, Henrique Douglas Melo Coutinho, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes Vegetos, 2025
Bibliometric analysis of the species Anacardium occidentale L. associated with scientometric networks Adrielle Rodrigues Costa, Carlos Vinicius Barros Oliveira, Maria Elenilda Paulino da Silva, Patric Anderson Gomes da Silva, Waseem Hassan, Mehreen Zafar, José Weverton Almeida-Bezerra, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Christophe Hano, Ivo Cavalcante Pita Neto, Claudener Souza Teixeira, Antonia Eliene Duarte, Luiz Marivando Barros Vegetos, 2025
ADME/Tox study and the effect of β-Caryophyllene on the resistant strain of Staphylococcus aureus carrying the QacA/B efflux pump gene José Weverton Almeida-Bezerra, José Thyálisson da Costa Silva, Maria Flaviana Bezerra Morais-Braga, Rafael Pereira da Cruz, Gabriel Gonçalves Alencar, Daniel Sampaio Alves, Ewerton Yago de Sousa Rodrigues, Simone Galdino de Sousa, Irwin Rose Alencar de Menezes, Janaína Esmeraldo Rocha, José Maria Barbosa Filho, Carlos Alonso Leite dos Santos, Adrielle Rodrigues Costa, Carolina Bandeira Domiciano, Lucia Raquel de Lima, Henrique Douglas Melo Coutinho Toxicology Reports, 2025
Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Isaac Moura Araújo, João Arthur de Oliveira Borges, Ray Silva Almeida, José Bezerra de Araújo-Neto, Cícera Datiane de Moraes Oliveira-Tintino, Igor José dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Helcio Silva dos Santos, Julia Mariana Assis da Silva, Tereza Cristina Leal Balbino, Irwin Rose de Alencar Menezes, Saulo Relison Tintino, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais Braga Gene Reports, 2025
Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches Priscilla Ramos Freitas, Ana Carolina Justino de Araújo, Isaac Moura Araújo, Ray Silva Almeida, João Arthur de Oliveira Borges, Clara Mariana Gonçalves Lima, Cícera Datiane Morais Oliveira-Tintino, Cícera Laura Roque Paulo, Gustavo Marinho Miranda, José Bezerra de Araújo-Neto, José Weverton Almeida-Bezerra, Igor José dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonca Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Irwin Rose Alencar de Menezes, Saulo Relison Tintino, Henrique Douglas Melo Coutinho Biochimie, 2025
Study of the Antioxidant and Antibacterial Effects of Genipa americana L. Against Food Pathogens Lariza Leisla Leandro Nascimento, Geane Gabriele de Oliveira Souza, Ana Cecília Calixto Donelardy, Maria Inácio da Silva, Cícera Alane Coelho Gonçalves, Ana Maria Duarte Fernandes, José Walber Gonçalves Castro, Débora Odília Duarte Leite, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues Foods, 2025
Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the Staphylococcus aureus 1199B Strain Cicera Laura Roque Paulo, Priscilla Ramos Freitas Alexandre, Ana Carolina Ferreira Araujo, Ray Silva Almeida, Emílio Sousa Albuquerque, Cícera Datiane de Morais Oliveira-Tintino, Igor J. S. Nascimento, João Xavier Araújo-Júnior, Edeildo Ferreira da Silva-Junior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça-Junior, José Bezerra de Araújo-Neto, Maria Karollyna do Nascimento Silva Leandro, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Janaina Esmeraldo Rocha Pharmaceuticals, 2025
Characterization and analysis of the bioactivity of the Piper rivinoides Kunth essential oil and its components myristicin and elemicin, against opportunistic fungal pathogens Victor Juno Alencar Fonseca, Sarah Castro dos Santos, Joara Nályda Pereira Carneiro, Antonia Thassya Lucas dos Santos, Maria Audilene de Freitas, Natália Kelly Gomes de Carvalho, Francildo dos Santos Silva, Andressa Guilhermino dos Santos, Aparecida Vitória Silva Menêses, Naiza Saraiva Farias, Rivânia Pereira dos Santos, Ricardo Andrade Rebelo, Martinho Rau, Luiz Everson da Silva, Wanderlei do Amaral, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Maria Flaviana Bezerra Morais-Braga Microbial Pathogenesis, 2025
Biphasic effect of limonene on contraction of isolated rat aorta Renata Evaristo Rodrigues da Silva, Luís Pereira-de-Morais, Andressa de Alencar Silva, Carla Mikevely de Sena Bastos, Emanuel Kennedy-Feitosa, Irwin Rose Alencar de Menezes, Daniel Weinreich, José Henrique Leal-Cardoso, Roseli Barbosa Chemico Biological Interactions, 2025
Antinociceptive Potential of Ximenia americana L. Bark Extract and Caffeic Acid: Insights into Pain Modulation Pathways Renata Torres Pessoa, Lucas Yure Santos da Silva, Isabel Sousa Alcântara, Tarcísio Mendes Silva, Eduardo dos Santos Silva, Roger Henrique Sousa da Costa, Aparecida Barros da Silva, Jaime Ribeiro-Filho, Anita Oliveira Brito Pereira Bezerra Martins, Henrique Douglas Melo Coutinho, Jean Carlos Pereira Sousa, Andréa Rodrigues Chaves, Ricardo Neves Marreto, Irwin Rose Alencar de Menezes Pharmaceuticals, 2024
Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains Erlânio Oliveira de Sousa, Anielle dos Santos Brito, Denise Magalhães Azevedo Feitoza, Aureliano de Albuquerque Ribeiro, Victória Hellen Nicácio Dias Tavares, Mayra Garcia Maia Costa, Crisiana de Andrade Nobre, Cícera Datiane de Morais Oliveira-Tintino, João Arthur de Oliveira Borges, Gildênia Alves de Araújo, Talysson Felismino Moura, João Paulo Martins de Lima, Sloana Giesta Lemos Florencio, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Saulo Relison Tintino Food Chemistry Advances, 2024
Antiparasitary potential of Sarcomphalus joazeiro (Mart.) Hauenschild (Rhamnaceae) Camila Aparecida P. Silva, Nara Juliana S. Araújo, Ana Raquel P. da Silva, Maria do Socorro Costa, Juliete B. Soares, Yedda Maria L.S. de Matos, José Weverton A. Bezerra, Viviane B. da Silva, Erlânio O. de Souza, Maria Celeste V. Gomez, Míriam Rolóm, Cathia Coronel, Jaime Ribeiro-Filho, José Maria Barbosa Filho, Davi Antas e Silva, Lucia Raquel de Lima, Irwin R.A. Menezes, Henrique D.M. Coutinho, Jacqueline C. Andrade-Pinheiro Pharmacological Research Natural Products, 2024
Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Isaac Moura Araújo, João Arthur de Oliveira Borges, Sheila Alves Gonçalves, Cícera Laura Roque Paulo, Ray Silva Almeida, Cícera Datiane de Moraes Oliveira-Tintino, José Bezerra de Araújo-Neto, Igor José dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Helcio Silva dos Santos, Irwin Rose de Alencar Menezes, Saulo Relison Tintino, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais Braga Current Microbiology, 2024
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration Priscilla R. Freitas, Ana C.J. de Araújo, Isaac M. Araújo, Ray S. de Almeida, João A.O. Borges, Cícera L.R. Paulo, Cícera D.M. Oliveira-Tintino, Gustavo M. Miranda, José B. Araújo-Neto, Igor J.S. Nascimento, João X. Araújo-Júnior, Julia M.A. Silva, Tereza C.L. Balbino, Edeildo F. Silva-Júnior, Thiago M. Aquino, Francisco J.B. Mendonca-Junior, Emmanuel S. Marinho, Hélcio S. Santos, Clara Mariana Gonçalves Lima, Ahmad J. Obaidullah, Talha Bin Emran, Francisco A.B. Cunha, Irwin R.A. Menezes, Saulo R. Tintino, Henrique D.M. Coutinho Biomedicine and Pharmacotherapy, 2024
Vasorelaxant effect of phenylpropanoids: Methyl eugenol and eugenol in human umbilical cord vein Andressa de Alencar Silva, Luís Pereira de Morais, Carla Mikevely de Sena Bastos, Debora de Menezes Dantas, Paulo Ricardo Batista, Francisco Junio Dias, Irwin Rose Alencar de Menezes, José Henrique Leal Cardoso, António Raposo, Heesup Han, Henrique Douglas Melo Coutinho, Roseli Barbosa Biomedicine and Pharmacotherapy, 2024
Unlocking bacterial defense: Exploring the potent inhibition of NorA efflux pump by coumarin derivatives in Staphylococcus aureus Ana Luíza A.R. Martin, Raimundo Luiz Silva Pereira, Janaína Esmeraldo Rocha, Pablo A.M. Farias, Thiago S. Freitas, Francisco Rodrigo de Lemos Caldas, Fernando G. Figueredo, Nadghia Figueiredo Leite Sampaio, Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Gabriel Costa A. da Hora, Maria Carolina Pacheco Lima, Irwin Rose A. de Menezes, Diogo T. Carvalho, Henrique D.M. Coutinho, Marta M.F. Fonteles Microbial Pathogenesis, 2024
Wound Healing Effect of Lippia sidoides and Myracrodruon urundeuva Nanogel Fernanda Pires Rodrigues de Almeida Ribeiro, Luana Fernandes Matos, Dinalva Brito Queiroz, Marco Antônio Botelho, Dra.Rosana de Souza Siqueira Barreto, Ricardo Santana de Lima, Luciano Augusto de Araújo Ribeiro, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Jackson Roberto Guedes da Silva Almeida Chemistry and Biodiversity, 2024
Meldrum's acid derivates are MepA efflux pump inhibitors: In vitro and in silico essays Isaac Moura Araújo, Raimundo Luiz Silva Pereira, Ana Carolina Justino de Araújo, Sheila Alves Gonçalves, Saulo Relison Tintino, Cícera Datiane de Morais Oliveira‐Tintino, Irwin Rose Alencar de Menezes, Renata Salamoni, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Ana Pavla Almeida Diniz Gurgel, Henrique Douglas M. Coutinho Journal of Basic Microbiology, 2024
Perillyl Alcohol Promotes Relaxation in Human Umbilical Artery Carla Mikevely de Sena Bastos, Luis Pereira-de-Morais, Andressa de Alencar Silva, Débora de Menezes Dantas, Paulo Ricardo Batista, Maria Franciele Lima Gomes, Gyllyandeson de Araújo Delmondes, Irwin Rose Alencar de Menezes, Renata Evaristo Rodrigues da Silva, Roseli Barbosa Current Medicinal Chemistry, 2024
Effects of Passiflora cincinnata in murine models of nociception Emmily Petícia do Nascimento Sales, Francisco Romero Cabral, Valterlúcio dos Santos Sales, Josefa Fernanda Evangelista de Lacerda, Luanna Gomes da Silva, Denise Bezerra Correia, Gyllyandeson de Araújo Delmondes, Cícera Norma Fernandes Lima, Álefe Brito Monteiro, Cícero Francisco Bezerra Felipe, Francisco Antonio Vieira dos Santos, Jaime Ribeiro-Filho, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Marta Regina Kerntopf Biologia, 2024
Biochemical aspects of the inflammatory process: A narrative review Caroline Leal Rodrigues Soares, Polrat Wilairatana, Larissa Rodrigues Silva, Polyanna Silva Moreira, Nayana Maria Medeiros Vilar Barbosa, Pablo Rayff da Silva, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Cícero Francisco Bezerra Felipe Biomedicine and Pharmacotherapy, 2023
Antiedematogenic and Analgesic Activities of Abietic Acid in Mice Maria Gabriely de Lima Silva, Lucas Yure Santos da Silva, Renata Torres Pessoa, Maria Rayane Correia de Oliveira, Francisco Lucas Alves Batista, Isabel Sousa Alcântara, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro‐Filho, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes Chemistry and Biodiversity, 2023
Vasorelaxant effect of (E,E)-farnesol in human umbilical vein ex vivo assays Paulo Ricardo Batista, Andressa de Alencar Silva, Carla Mikevely de Sena Bastos, Alex de Souza Borges, Francisco Junio Dias, Luiz Ramon dos Santos Pereira, Sara Tavares de Sousa Machado, Gyllyandeson de Araújo Delmondes, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes, Roseli Barbosa Chemico Biological Interactions, 2023
Inhibition of the norA gene expression and the NorA efflux pump by the tannic acid Saulo Relison Tintino, Polrat Wilairatana, Veruska Cintia Alexandrino de Souza, Julia Mariana Assis da Silva, Pedro Silvino Pereira, Cícera Datiane de Morais Oliveira-Tintino, Yedda Maria Lobo Soares de Matos, João Tavares Calixto Júnior, Valdir de Queiroz Balbino, José P. Siqueira-Junior, Irwin Rose Alencar Menezes, Abolghasem Siyadatpanah, Henrique Douglas Melo Coutinho, Tereza Cristina Leal Balbino Scientific Reports, 2023
Comparative antimicrobial potential of Ocimum basilicum essential oil, estragole and estragole/β-cyclodextrin complex in an infection model on adult zebrafish Francisco Lucas A. Batista, Jacqueline Cosmo Andrade-Pinheiro, Antonia Thassya L. dos Santos, Jessyca Nayara M. Lima, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, Ana Raquel Pereira da Silva, Natália Kelly Gomes de Carvalho, Anita Oliveira Brito Pereira B. Martins, Roger Henrique S. da Costa, Lindaiane Bezerra Rodrigues, Henrique Douglas M. Coutinho, José Galberto Martins da Costa, Francisco Ernani A. Magalhães, Irwin Rose Alencar de Menezes Carbohydrate Polymer Technologies and Applications, 2023
In vitro and in silico evidences about the inhibition of MepA efflux pump by coumarin derivatives Ana Luíza A.R. Martin, Raimundo Luiz Silva Pereira, Janaína Esmeraldo Rocha, Pablo A.M. Farias, Thiago S. Freitas, Francisco Rodrigo de Lemos Caldas, Fernando G. Figueredo, Nadghia Figueiredo Leite Sampaio, Jaime Ribeiro-Filho, Irwin Rose de Alencar Menezes, Guilherme Andrade Brancaglion, Daniela Carvalho de Paulo, Diogo T. Carvalho, Micheline Azevedo Lima, Henrique D.M. Coutinho, Marta M.F. Fonteles Microbial Pathogenesis, 2023
Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings Maysa de Oliveira Barbosa, Polrat Wilairatana, Giovana Mendes de Lacerda Leite, Gyllyandeson de Araújo Delmondes, Lucas Yure Santos da Silva, Silvio Caetano Alves Júnior, Lindaiane Bezerra Rodrigues Dantas, Daniel Souza Bezerra, Izabel Cristina Santiago Lemos de Beltrão, Diógenes de Queiroz Dias, Jaime Ribeiro-Filho, Cícero Francisco Bezerra Felipe, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Marta Regina Kerntopf Mendonça Molecules, 2023
Vasodilation promoted by (E,E)-farnesol involving ion channels in human umbilical arteries Paulo Ricardo Batista, Andressa de Alencar Silva, Carla Mikevely de Sena Bastos, Renata Evaristo Rodrigues da Silva, Gabriela Lucena Calixto, Luís Pereira de Morais, Gyllyandeson de Araújo Delmondes, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes, Roseli Barbosa Heliyon, 2023
Ximenia americana L.: Chemical Characterization and Gastroprotective Effect Renata Torres Pessoa, Isabel Sousa Alcântara, Lucas Yure Santos da Silva, Roger Henrique Souza da Costa, Tarcísio Mendes Silva, Cícera Datiane de Morais Oliveira-Tintino, Andreza Guedes Barbosa Ramos, Maria Rayane Correia de Oliveira, Anita Oliveira Brito Pereira Bezerra Martins, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Edlane Martins de Andrade, Jaime Ribeiro-Filho, Clara Mariana Gonçalves Lima, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes Analytica, 2023
Photobiological effect of eugenol-derived 3-benzoylcoumarin associated with led lights against MDR microorganisms Amanda Karine de Sousa, Janaina Esmeraldo Rocha, Thiago Sampaio de Freitas, Priscila Ramos Freitas, Raimundo Luiz Silva Pereira, Francisco Nascimento Pereira Júnior, Guilherme Andrade Brancaglion, Daniela Carvalho de Paulo, Diogo Teixeira Carvalho, Irwin Rose Alencar de Menezes, Francisco Antonio Vieira dos Santos, Henrique Douglas Melo Coutinho, Lucindo José Quintans Júnior Fundamental and Clinical Pharmacology, 2023
Antibacterial Activity and Anxiolytic Effect in Adult Zebrafish of Genus Lippia L. Species Carla de Fatima Alves Nonato, Emerson Vinicius Silva de Melo, Cicera Janaine Camilo, Maria Kueirislene Amâncio Ferreira, Jane Eire Alencar de Meneses, Antonio Wlisses da Silva, Hélcio Silva dos Santos, Jaime Ribeiro-Filho, Joanda Paolla Raimundo e Silva, Josean Fechine Tavares, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Tomasz Baj, Radosław Kowalski, José Galberto Martins da Costa Plants, 2023
Efflux Pump (QacA, QacB, and QacC) and β-Lactamase Inhibitors? An Evaluation of 1,8-Naphthyridines against Staphylococcus aureus Strains Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Ana Carolina Justino de Araújo, Cristina Rodrigues dos Santos Barbosa, Priscilla Ramos Freitas, José Bezerra de Araújo Neto, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Humberto Medeiros Barreto, Jaime Ribeiro-Filho, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho Molecules, 2023
Antibacterial effect, efflux pump inhibitory (NorA, TetK and MepA) of Staphylococcus aureus and in silico prediction of α, β and δ-damascone compounds Maria Rayane Correia de Oliveira, Maria Gabriely de Lima Silva, Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Janaina Esmeraldo Rocha, Francisco Ernani Alves Magalhães, Roger Henrique Sousa da Costa, Renata Torres Pessoa, Isabel Sousa Alcântara, Anita Oliveira Brito Pereira Bezerra Martins, Henrique Douglas Melo Coutinho, António Raposo, Conrado Carrascosa, José Raduan Jaber, Rogério Aquino Saraiva, Irwin Rose Alencar de Menezes Arabian Journal of Chemistry, 2023
Consensus of the medicinal use of Copaifera langsdorffii Desf. in different phytophysiognomies Revista Brasileira De Plantas Medicinais, 2023
Lectin Purification through Affinity Chromatography Exploiting Macroporous Monolithic Adsorbents Josiane F. da Silva, Clara M. G. Lima, Débora L. da Silva, Ivonea S. do Nascimento, Sarah de O. Rodrigues, Letícia A. Gonçalves, Renata F. Santana, Waseem Khalid, Silvani Verruck, Talha Bin Emran, Irwin R. A. de Menezes, Henrique D. M. Coutinho, Mayeen U. Khandaker, Mohammad R. I. Faruque, Rafael da C. I. Fontan Separations, 2023
NorA, Tet(K), MepA, and MsrA Efflux Pumps in Staphylococcus aureus, their Inhibitors and 1,8-Naphthyridine Sulfonamides Henrique Douglas Melo Coutinho, Cícera Datiane de Morais Oliveira-Tintino, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Carlos Vinicius Barros Oliveira, Pedro Silvino Pereira, Alexandre Magno Rodrigues Teixeira, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Teresinha Gonçalves da Silva Current Pharmaceutical Design, 2023
Effect of Lippia alba (Mill.) N.E. Brown Essential Oil on the Human Umbilical Artery Alex S. Borges, Carla M. S. Bastos, Debora M. Dantas, Cícera G. B. Milfont, Guilherme M. H. Brito, Luís Pereira-de-Morais, Gyllyandeson A. Delmondes, Renata E. R. da Silva, Emanuel Kennedy-Feitosa, Francisco P. A. Maia, Clara M. G. Lima, Talha Bin Emran, Henrique Douglas M. Coutinho, Irwin Rose A. Menezes, Marta R. Kerntopf, Gianluca Caruso, Roseli Barbosa Plants, 2022
Mechanisms of Actions Involved in The Antinociceptive Effect of Estragole and its β-Cyclodextrin Inclusion Complex in Animal Models Roger Henrique Sousa da Costa, Anita Oliveira Brito Pereira Bezerra Martins, Renata Torres Pessoa, Saad Ali Alshehri, Shadma Wahab, Md Faruque Ahmad, Muath Suliman, Lucas Yure Santos da Silva, Isabel Sousa Alcântara, Andreza Guedes Barbosa Ramos, Maria Rayane Correia de Oliveira, Francisco Lucas Alves Batista, Gyllyandeson de Araújo Delmondes, Pablo Antonio Maia de Farias, Janaína Esmeraldo Rocha, Henrique Douglas Melo Coutinho, António Raposo, Conrado Carrascosa, José Raduan Jaber, Irwin Rose Alencar de Menezes Plants, 2022
Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil Andreza G.R. Barbosa, Cícera D.M.O. Tintino, Renata T. Pessoa, Luiz J. de Lacerda Neto, Anita O.B.P.B. Martins, Maria R.C. de Oliveira, Henrique D.M. Coutinho, Natália Cruz-Martins, Lucindo J. Quintans Junior, Polrat Wilairatana, Irwin R.A. de Menezes Biotechnology Reports, 2022
In vivo and in silico anti-inflammatory properties of the sesquiterpene valencene Lindaiane B.R. Dantas, Isabel S. Alcântara, Cícero Pedro S. Júnior, Maria Rayane C. de Oliveira, Anita O.B.P.B. Martins, Ticiano M. Dantas, Jaime Ribeiro-Filho, Henrique Douglas M. Coutinho, Fabíolla R.S. Passos, Lucindo J. Quintans-Júnior, Jackson Roberto G.S. Almeida, Natália Cruz-Martins, Bonglee Kim, Irwin Rose Alencar de Menezes Biomedicine and Pharmacotherapy, 2022
Central depressant effects of Piper tuberculatum Jacq essential oil in mice Valterlúcio dos Santos Sales, Francisco Romero Cabral, Emmily Petícia do Nascimento Sales, Tatyelle Bezerra Carvalho, Maria Haiele Nogueira Costa, Victor Afonso Pereira de Oliveira, Cristina Kelly de Souza Rodrigues, Francisco Rodolpho Sobreira Dantas Nóbrega de Figueirêdo, Daniel Souza Bezerra, Gyllyandeson de Araújo Delmondes, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Food Bioscience, 2022
Evaluation of the antifungal activity of α, β, and δ-damascone and inclusion complexes in β-cyclodextrin against Candida spp Maria Rayane Correia de Oliveira, Maria Gabriely de Lima Silva, Antonia Thassya Lucas dos Santos, Francisco Lucas Alves Batista, Roger Henrique Sousa da Costa, Anita Oliveira Brito Pereira Bezerr Martins, Beatriz Gonçalves da Cruz, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho, Francisco Ernani Alves Magalhães, Diniz Maciel de Sena Junior, Alexandre Magno Rodrigues Teixeira, Irwin Rose Alencar de Menezes Folia Microbiologica, 2022
Inhibition of the MepA efflux pump by limonene demonstrated by in vitro and in silico methods Priscilla Ramos Freitas, Ana Carolina Justino de Araújo, Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Ray Silva de Almeida, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Fabiola Fernandes Galvão Rodrigues, Janaína Esmeraldo Rocha, Francisco Nascimento Pereira-Junior, Saulo Relison Tintino, Henrique Douglas Melo Coutinho Folia Microbiologica, 2022
Leishmanicidal and trypanocidal potential of the essential oil of Psidium myrsinites DC. Lilian Cortez Sombra Vandesmet, Saulo Almeida de Menezes, Benedito Yago Machado Portela, Mariana Gomes Vidal Sampaio, Cícero Ramon Bezerra dos Santos, Vilmar Luiz Lermen, Maria Celeste Vega Gomez, Márcia Vanusa da Silva, Irwin Rose de Alencar Menezes, Maria Tereza dos Santos Correia Natural Product Research, 2022
Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats Enaide Soares Santos, Geraldo Lucas Abrantes Coelho, Yan Kauê Saraiva Fontes Loula, Bárbara Lourenço Saraiva Landim, Cícera Norma Fernandes Lima, Sara Tavares de Sousa Machado, Maria Janice Pereira Lopes, Acléssia Damiana Soares Gomes, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Bonglee Kim, Cícero Francisco Bezerra Felipe, Samya de Araújo Neves, Marta Regina Kerntopf Evidence Based Complementary and Alternative Medicine, 2022
Serological and molecular epidemiology of the Dengue, Zika and Chikungunya viruses in a risk area in Brazil Magaly Lima Mota, Robson dos Santos Souza Marinho, Rodrigo Lopes Sanz Duro, James Hunter, Irwin Rose Alencar de Menezes, João Marcos Ferreira de Lima Silva, Glaubervânio Leite Tavares Pereira, Ester Cerdeira Sabino, Anete Grumach, Ricardo Sobhie Diaz, Maria do Socorro Lucena, Shirley Vasconcelos Komninakis BMC Infectious Diseases, 2021
Topical anti-inflammatory effect of hydroalcoholic extract of leaves of Licania rigida Benth. in mice Enaide Soares Santos, Cícera Datiane de Morais Oliveira-Tintino, Denise Bezerra Correia, Cícero Damon Carvalho de Alencar, Maria de Fátima Sousa, Cícera Norma Fernandes Lima, Sara Tavares de Sousa Machado, Acléssia Damiana Soares Gomes, Francisca Adilfa de Oliveira Garcia, Irwin Rose Alencar Menezes, Aline Augusti Boligon, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Phytomedicine Plus, 2021
Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Pedro Silvino Pereira, Sandrine Maria de Arruda Lima, Cícera Datiane de Morais Oliveira Tintino, Veruska Cintia Alexandrino de Souza, Julia Mariana Assis da Silva, Roger Henrique Sousa da Costa, Jacqueline Cosmo Andrade Pinheiro, Yedda Maria Lobo Soares de Matos, Irwin Rose Alencar Menezes, Teresinha Gonçalves da Silva, Gláucia Manoella de Souza Lima, Tereza Cristina Leal Balbino, José Pinto Siqueira-Júnior, Francisco Assis Bezerra da Cunha, Henrique Douglas Melo Coutinho, Saulo Relison Tintino Bioorganic and Medicinal Chemistry Letters, 2021
Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice Maria Rayane Correia de Oliveira, Maria Gabriely de Lima Silva, Isabel Sousa Alcântara, Jaime Ribeiro Filho, Cícera Datiane de Morais Oliveira Tintino, Francisco Ernani Alves Magalhães, Anita Oliveira Brito Pereira Bezerr Martins, Renata Torres Pessoa, Antonia Eliene Duarte, José Galberto Martins da Costa, Sidney Gonçalo de Lima, Henrique Douglas Melo Coutinho, Raffaele Capasso, Irwin Rose Alencar de Menezes Environment Development and Sustainability, 2021
Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives Patrícia Gonçalves Pinheiro, Gilvandete Maria Pinheiro Santiago, Francisco Erivaldo Freitas da Silva, Ana Carolina Justino de Araújo, Cícera Rejane Tavares de Oliveira, Priscilla Ramos Freitas, Janaína Esmeraldo Rocha, José Bezerra de Araújo Neto, Maria Milene Costa da Silva, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa Asian Pacific Journal of Tropical Biomedicine, 2021
Pharmacological and toxicological activities of α-humulene and its isomers: A systematic review Giovana Mendes de Lacerda Leite, Maysa de Oliveira Barbosa, Maria Janice Pereira Lopes, Gyllyandeson de Araújo Delmondes, Daniel Souza Bezerra, Isaac Moura Araújo, Cícero Damon Carvalho de Alencar, Henrique Douglas Melo Coutinho, Laisla Rangel Peixoto, José Maria Barbosa-Filho, Cícero Francisco Bezerra Felipe, Roseli Barbosa, Irwin Rose Alencar de Menezes, Marta Regina Kerntof Trends in Food Science and Technology, 2021
FTIR analysis and reduction of the phytotoxic effect of mercury dichloride by rutin Yedda Maria Lobo Soares de Matos, Janaina Esmeraldo Rocha, Celestina Elba Sobral Souza, Tássia Thaís Al Yafawi, José Bezerra de Araújo Neto, Fabia Ferreira Campina, Jacqueline Cosmo Andrade Pinheiro, Thiago Sampaio de Freitas, Amanda Karine Sousa, Saulo Relison Tintino, Maria Flaviana Bezerra Morais Braga, Daniel Linhares Militão Vasconcelos, Antonio César Honorato Barreto, João Hermínio da Silva, Irwin Rose Alencar Menezes, Raimundo Nonato Pereira Teixeira, Juan Carlos Alvarez-Pizarro, Henrique Douglas Melo Coutinho Rhizosphere, 2021
Effect of Carvacrol and Thymol on NorA efflux pump inhibition in multidrug-resistant (MDR) Staphylococcus aureus strains Cristina Rodrigues dos Santos Barbosa, Jackelyne Roberta Scherf, Thiago Sampaio de Freitas, Irwin Rose Alencar de Menezes, Raimundo Luiz Silva Pereira, Joycy Francely Sampaio dos Santos, Sarah Silva Patrício de Jesus, Thais Pereira Lopes, Zildene de Sousa Silveira, Cícera Datiane de Morais Oliveira-Tintino, José Pinto Siqueira Júnior, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Francisco Assis Bezerra da Cunha Journal of Bioenergetics and Biomembranes, 2021
Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains Raimundo Luiz Silva Pereira, Fábia Ferreira Campina, Maria do Socorro Costa, Rafael Pereira da Cruz, Thiago Sampaio de Freitas, Antonia Thassya Lucas dos Santos, Beatriz Gonçalves Cruz, Diniz Maciel de Sena Júnior, Igor Kleber Campos Lima, Maria Regivânia Xavier, Alexandre Magno Rodrigues Teixeira, Irwin Rose Alencar de Menezes, Lucindo José Quintans-Júnior, Adriano A. de S. Araújo, Henrique Douglas Melo Coutinho Microbial Pathogenesis, 2021
Antinociceptive Effect of Volatile Oils from Ocimum basilicum Flowers on Adult Zebrafish Francisco Lucas A. Batista, José Ismael F. de Araújo, Sandra Maria B. de Araújo, Daniela Braga de Sousa, Francisco Bastos C. Sobrinho, Franciglauber Silva Bezerra, Maria Gabriely de Lima Silva, Maria Rayane C. de Oliveira, Roger Henrique S. da Costa, Lindaiane Bezerra Rodrigues, Francisco Ernani A. Magalhães, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes Revista Brasileira De Farmacognosia, 2021
Effect of the Croton rhamnifolioides Essential Oil and the Inclusion Complex (OEFC/β-CD) in Antinociceptive Animal Models Anita Oliveira Brito Pereira Bezerra Martins, Maria Rayane Correia de Oliveira, Isabel Sousa Alcântara, Lindaiane Bezerra Rodrigues, Francisco Rafael Alves Santana Cesário, Maria Sanadia Alexandre da Silva, Fyama Ferreira e Castro, Emmily Petícia do Nascimento, Thaís Rodrigues de Albuquerque, Lucindo José Quintans Júnior, Adriano Antunes de Souza Araújo, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley Macromol, 2021
FTIR analysis of pyrogallol and phytotoxicity-reductive effect against mercury chloride Janaina E. Rocha, Tássia T. A. M. Guedes, Camila F. Bezerra, Maria do S. Costa, Fabia F. Campina, Thiago S. de Freitas, Amanda K. Sousa, Celestina E. Sobral Souza, Maria K. N. Silva, Yedda M. Lobo, Francisco N. Pereira-Junior, João H. da Silva, Irwin R. A. Menezes, Raimundo N. P. Teixeira, Aracélio V. Colares, Henrique D. M. Coutinho Environmental Geochemistry and Health, 2021
Chemical synthesis, molecular docking and MepA efflux pump inhibitory effect by 1,8-naphthyridines sulfonamides Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Pedro Silvino Pereira, Tereza Cristina Leal Balbino, José Galberto Martins da Costa, Fabiola Fernandes Galvão Rodrigues, Alexandre Magno Rodrigues Teixeira, Humberto Medeiros Barreto, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Teresinha Gonçalves da Silva European Journal of Pharmaceutical Sciences, 2021
The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitors Cícera Datiane de Morais Oliveira-Tintino, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Pedro Silvino Pereira, José Galberto Martins da Costa, Fabiola Fernandes Galvão Rodrigues, Alexandre Magno Rodrigues Teixeira, Jaime Ribeiro-Filho, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Teresinha Gonçalves da Silva Journal of Global Antimicrobial Resistance, 2021
In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Irwin Rose Alencar de Menezes, Erlânio Oliveira de Sousa, Raimundo Luiz Silva Pereira, João Tavares Calixto Júnior, Pedro Silvino Pereira, Yedda M.L.S. de Matos, Roger H.S. da Costa, Cícera Datiane de Morais Oliveira-Tintino, Henrique Douglas Melo Coutinho, José Maria Barbosa Filho, Gabriela Ribeiro de Sousa, Jaime Ribeiro Filho, José Pinto Siqueira-Junior, Saulo Relison Tintino Food Chemistry, 2021
Chemical composition, antioxidant and antiprotozoal activity of Eugenia gracillima Kiaersk. leaves essential oil Mariana Gomes Vidal Sampaio, Cícero Ramon Bezerra Dos Santos, Lilian Cortez Sombra Vandesmet, Bruno Souza Dos Santos, Izabelly Bianca Da Silva Santos, Maria Tereza dos Santos Correia, Arthur Lima de Berrêdo Martins, Luis Claudio Nascimento da Silva, Irwin Rose De Alencar Menezes, Maria Celeste Veja Gomez, Márcia Vanusa Da Silva Natural Product Research, 2021
UPLC–MS–QTOF analysis and antifungal activity of Cumaru (Amburana cearensis) Maria Tatiana Alves Oliveira, Marcus Vinícius Oliveira Barros de Alencar, Vicente de Paulo dos Anjos Landim, Geovanna Maria Medeiros Moura, Joelton Igor Oliveira da Cruz, Elizeu Antunes dos Santos, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade, Irwin Rose Alencar de Menezes, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Erlânio Oliveira de Sousa, Adriana Ferreira Uchoa 3 Biotech, 2020
Phytochemical profile of Anacardium occidentale L. (cashew tree) and the cytotoxic and toxicological evaluation of its bark and leaf extracts Adrielle Rodrigues Costa, Jailson Renato de Lima Silva, Thalyta Julyanne Silva de Oliveira, Teresinha Gonçalves da Silva, Pedro Silvino Pereira, Elizabeth Fernanda de Oliveira Borba, Edy Sousa de Brito, Paulo Riceli Vasconcelos Ribeiro, José Weverton Almeida-Bezerra, João Tavares Calixto Júnior, Irwin Rose Alencar de Menezes, Jean Paul Kamdem, Antonia Eliene Duarte, Luiz Marivando Barros South African Journal of Botany, 2020
Machaerium acutifolium lectin inhibits inflammatory responses through cytokine modulation Ana L.E. Santos, Cícero P.S. Júnior, Roberval N.M. Neto, Maria. H.C. Santos, Valdenice F. Santos, Bruno A.M. Rocha, Eduardo M. Sousa, Rafael C. Carvalho, Irwin R.A. Menezes, Maria R.C. Oliveira, Lindaiane B.R. Dantas, Tarcísio M. Silva, Claudener S. Teixeira Process Biochemistry, 2020
Do 1,8-naphthyridine sulfonamides possess an inhibitory action against Tet(K) and MsrA efflux pumps in multiresistant Staphylococcus aureus strains? Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Pedro Silvino Pereira, Alexandre Magno Rodrigues Teixeira, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Teresinha Gonçalves da Silva Microbial Pathogenesis, 2020
UPLC-MS-ESI-QTOF analysis and Anti-Candida activity of fractions from Psidium guajava L. Camila Fonseca Bezerra, Janaína Esmeraldo Rocha, Maria Karollyna do Nascimento Silva, Thiago Sampaio de Freitas, Amanda Karine de Sousa, Joara Nályda Pereira Carneiro, Antônio Linkoln Alves Borges Leal, Antônia Thassya Lucas dos Santos, Rafael Pereira da Cruz, Allana Silva Rodrigues, Débora Lima Sales, Henrique Douglas Melo Coutinho, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Waltécio de Oliveira Almeida, Maria Flaviana Bezerra Morais-Braga South African Journal of Botany, 2020
Effect of vitamin K3 inhibiting the function of nora efflux pump and its gene expression on staphylococcus aureus Saulo R. Tintino, Veruska C. A. de Souza, Julia M. A. da Silva, Cícera Datiane de M. Oliveira-Tintino, Pedro S. Pereira, Tereza C. Leal-Balbino, Antonio Pereira-Neves, José P. Siqueira-Junior, José G. M. da Costa, Fabíola F. G. Rodrigues, Irwin R. A. Menezes, Gabriel C. A. da Hora, Maria C. P. Lima, Henrique D. M. Coutinho, Valdir Q. Balbino Membranes, 2020
Anti-inflammatory and physicochemical characterization of the croton rhamnifolioides essential oil inclusion complex in β-cyclodextrin Anita Oliveira Brito Pereira Bezerra Martins, Almir Gonçalves Wanderley, Isabel Sousa Alcântara, Lindaiane Bezerra Rodrigues, Francisco Rafael Alves Santana Cesário, Maria Rayane Correia de Oliveira, Fyama Ferreira e Castro, Thaís Rodrigues de Albuquerque, Maria Sanadia Alexandre da Silva, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Paula Passos Menezes, Lucindo José Quintans-Júnior, Adriano Antunes de Souza Araújo, Marcello Iriti, Jackson Roberto Guedes da Silva Almeida, Irwin Rose Alencar de Menezes Biology, 2020
Nootkatone Inhibits Acute and Chronic Inflammatory Responses in Mice Lindaiane Bezerra Rodrigues Dantas, Ana Letícia Moreira Silva, Cícero Pedro da Silva Júnior, Isabel Sousa Alcântara, Maria Rayane Correia de Oliveira, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Fabíolla Rocha Santos Passos, Lucindo José Quintans-Junior, Irwin Rose Alencar de Menezes, Raffaele Pezzani, Sara Vitalini Molecules Basel Switzerland, 2020
Nootkatone inhibits acute and chronic inflammatory responses in mice Lindaiane Bezerra Rodrigues Dantas, Ana Letícia Moreira Silva, Cícero Pedro da Silva Júnior, Isabel Sousa Alcântara, Maria Rayane Correia de Oliveira, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Fabíolla Rocha Santos Passos, Lucindo José Quintans-Junior, Irwin Rose Alencar de Menezes, Raffaele Pezzani, Sara Vitalini Molecules, 2020
Pharmacological applications of farnesol (C15H26O): a patent review Gyllyandeson De Araújo Delmondes, Izabel Cristina Santiago Lemos, Diógenes De Queiroz Dias, Glacithane Lins Da Cunha, Isaac Moura Araújo, Roseli Barbosa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, José Maria Barbosa-Filho, Natanael Teles Ramos De Lima, Irwin Rose Alencar De Menezes, Marta Regina Kerntopf Expert Opinion on Therapeutic Patents, 2020
Anxiolytic and antidepressant-like effects of Annona coriacea (Mart.) and caffeic acid in mice Álefe Brito Monteiro, Cristina Kelly de Souza Rodrigues, Emmily Petícia do Nascimento, Valterlúcio dos Santos Sales, Gyllyandeson de Araújo Delmondes, Maria Haiele Nogueira da Costa, Victor Afonso Pereira de Oliveira, Luis Pereira de Morais, Aline Augusti Boligon, Roseli Barbosa, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Food and Chemical Toxicology, 2020
Seasonality influence on the chemical composition and antifungal activity of Psidium myrtoides O. Berg Delmacia Gonçalves de Macêdo, Marta Maria de Almeida Souza, Maria Flaviana B. Morais-Braga, Henrique Douglas M. Coutinho, Antonia Thassya L. dos Santos, Antonio Judson Targino Machado, Fábio Fernandes G. Rodrigues, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes South African Journal of Botany, 2020
Effect of α-bisabolol and its β-cyclodextrin complex as TetK and NorA efflux pump inhibitors in Staphylococcus aureus strains Rafael Pereira da Cruz, Thiago Sampaio de Freitas, Maria do Socorro Costa, Antonia Thassya Lucas dos Santos, Fábia Ferreira Campina, Raimundo Luiz Silva Pereira, José Weverton Almeida Bezerra, Lucindo José Quintans-Júnior, Adriano Antunes De Souza Araújo, José Pinto De Siqueira Júnior, Marcello Iriti, Elena Maria Varoni, Irwin Rose Alencar De Menezes, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga Antibiotics, 2020
Antinociceptive activity of the Psidium brownianum Mart ex DC. leaf essential oil in mice Renata de Souza Sampaio, Emmily Petícia do Nascimento, Irwin Rose Alencar de Menezes, Valterlúcio dos Santos Sales, Anita Oliveira Brito Pereira, Giovana Mendes de Lacerda, Enaide Soares Santos, Maria Janice Pereira Lopes, Luanna Gomes da Silva, Gyllyandeson de Araújo Delmondes, Nélio Barreto Vieira, Victor Mantoani Zaia, Daniel Souza Bezerra, José Galberto Martins da Costa, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Food and Chemical Toxicology, 2020
Antibiotic-Potentiating Activity of Phanostenine Isolated from Cissampelos sympodialis Eichler Walmir E. M. Cunha, Cicera J. Camilo, Carla de F. A. Nonato, Johnatan W. S. Mendes, Natália K. G. de Carvalho, Henrique D. M. Coutinho, Irwin R. A. Menezes, Telma L. G. de Lemos, Raimundo Braz‐Filho, Fabiola F. G. Rodrigues, Edinardo F. F. Matias, Gokhan Zengin, José G. M. Costa Chemistry and Biodiversity, 2019
Effects of the Hyptis martiusii Benth. leaf essential oil and 1,8-cineole (eucalyptol) on the central nervous system of mice Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo, Álefe Brito Monteiro, Irwin Rose Alencar de Menezes, Valterlúcio dos Santos Sales, Emmily Petícia do Nascimento, Cristina Kelly de Souza Rodrigues, Ana Jaqueline Bitu Primo, Luzia Paulo da Cruz, Érika do Nascimento Amaro, Gyllyandeson de Araújo Delmondes, Juliana Ponciano Leite de Oliveira Sobreira Nóbrega, Maria Janice Pereira Lopes, José Galberto Martins da Costa, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Food and Chemical Toxicology, 2019
Anti-inflammatory activity of herb products from Licania rigida Benth. Enaide Soares Santos, Cícera Datiane de Morais Oliveira, Irwin Rose Alencar Menezes, Emmily Petícia do Nascimento, Denise Bezerra Correia, Cícero Damon Carvalho de Alencar, Maria de Fátima Sousa, Cícera Norma Fernandes Lima, Álefe Brito Monteiro, Camila Pedroso Estevam de Souza, Gyllyandeson de Araújo Delmondes, Daniel Souza Bezerra, Francisca Adilfa de Oliveira Garcia, Aline Augusti Boligon, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Complementary Therapies in Medicine, 2019
Toxicological and pharmacologic effects of farnesol (C 15 H 26 O): A descriptive systematic review Gyllyandeson de Araújo Delmondes, Daniel Souza Bezerra, Diógenes de Queiroz Dias, Alex de Souza Borges, Isaac Moura Araújo, Glacithane Lins da Cunha, Paulo Felipe Ribeiro Bandeira, Roseli Barbosa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, José Maria Barbosa-Filho, Irwin Rose Alencar de Menezes, Marta Regina Kerntopf Food and Chemical Toxicology, 2019
Ximenia americana L. enhances the antibiotic activity and inhibit the development of kinetoplastid parasites Irwin Rose Alencar de Menezes, Roger Henrique Sousa da Costa, Aline Augusti Boligon, Miriam Rolón, Cathia Coronel, Celeste Vega, Henrique Douglas Melo Coutinho, Maria Socorro da Costa, Saulo Relison Tintino, Raimundo Luiz Silva Pereira, Thais Rodrigues de Albuquerque, Jackson Roberto Guedes da Silva Almeida, Lucindo José Quintans-Júnior Comparative Immunology Microbiology and Infectious Diseases, 2019
Mercury chloride phytotoxicity reduction using antioxidative mechanisms evidenced by caffeic acid FTIR Janaina E. Rocha, TássiaT.A.M. Guedes, Camila F. Bezerra, Maria do S. Costa, Fabia F. Campina, Thiago S. de Freitas, Amanda K. Souza, Celestina E. Sobral Souza, Maria K.N. Silva, Yedda M. Lobo, Francisco N. Pereira-Junior, João H. da Silva, Irwin R.A. Menezes, Raimundo N.P. Teixeira, Alexandre M.R. Teixeira, Aracélio V. Colares, Henrique D.M. Coutinho Applied Geochemistry, 2019
Comparative study of alpha- and beta-pinene effect on PTZ-induced convulsions in mice Cícero Francisco Bezerra Felipe, Aline Mirely Sousa Albuquerque, João Luis Xavier de Pontes, José Ítalo Vieira de Melo, Teresa Carolliny Moreira Lustoza Rodrigues, Ada Mirtes Pereira de Sousa, Álefe Brito Monteiro, Ana Elisa da Silva Ribeiro, Janice Pereira Lopes, Irwin Rose Alencar de Menezes, Reinaldo Nóbrega de Almeida Fundamental and Clinical Pharmacology, 2019
Central nervous system and analgesic profiles of Lippia genus Pollyana S. Siqueira-Lima, Fabiolla R.S. Passos, Angélica M. Lucchese, Irwin R.A. Menezes, Henrique D.M. Coutinho, Adley A.N. Lima, Gokhan Zengin, Jullyana S.S. Quintans, Lucindo J. Quintans-Júnior Revista Brasileira De Farmacognosia, 2019
Phenolic composition and antifungal effect of Costus cf. Arabicus l against yeast of the Candida genus Antonia Thassya Lucas Dos Santos, Antonio Júdson Targino Machado, Maria Audilene De Freitas, Irwin Rose Alencar De Menezes, Henrique Douglas Melo Coutinho, Francisco Assis Bezerra Da Cunha, Djair Dos Santos De Lima E Souza, Aline Augusti Boligon, Adeliana Silva De Oliveira, Andressa De Alencar Silva, Maria Flaviana Bezerra Morais-Braga Letters in Drug Design and Discovery, 2019
Phytochemical analysis and central effects of annona muricata linnaeus: Possible involvement of the gabaergic and monoaminergic systems Iranian Journal of Pharmaceutical Research, 2018
Toxicity against Drosophila melanogaster and antiedematogenic and antimicrobial activities of Alternanthera brasiliana (L.) Kuntze (Amaranthaceae) Henrique Douglas Melo Coutinho, Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Raimundo Luiz Silva Pereira, Thiago Sampaio de Freitas, Maria Arlene Pessoa da Silva, Jeferson Luis Franco, Francisco Assis Bezerra da Cunha, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Aline Augusti Boligon, João Batista Teixeira da Rocha, Maria Ivaneide Rocha, Joycy Francely Sampaio dos Santos Environmental Science and Pollution Research, 2018
Gastroprotective activity of hydroalcoholic extract of the stryphnodendron rotundifolium mart. In mice: mechanism actions assay Dayanne Rakelle de Oliveira, Lucindo Jose Quintans-Junior, Thais Rodrigues de Albuquerque, Francisco Elizaudo de Brito Junior, Cicera Norma Fernandes, Heloisa Helena Fernandes de Souza, Aline Augusti Boligon, Margareth Linde Athayde, Cicero Bezerra Felipe, Henrique Douglas Melo Coutinho, Roseli Barbosa, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes Letters in Drug Design and Discovery, 2018
Antimicrobial, gastroprotective and healing effect of the hydroalcoholic extract of astronium fraxinifolium Anita Oliveira Brito Pereira Bezerra Martins, Ana Luiza Albuquerque Siebra, Cicera Datiane de Morais Oliveira, Gerlania Oliveira Leite, Henrique Douglas Melo Coutinho, Margareth Linde Athayde, Aline Augusti Bolignon, Jacqueline Cosmo Andrade, Larissa Rolim Oliveira, Marta Regina Kerntopf, Roseli Barbosa, Francisco Rafael Alves Santana Cesario, Thales Silva Coutinho, Lucindo Jose Quintans-Junior, Irwin Rose Alencar de Menezes Letters in Drug Design and Discovery, 2018
Antiulcer activity and potential mechanism of action of the leaves of Spondias mombin L. Samara Alves Brito, Cynthia Layse Ferreira de Almeida, Temístocles Italo de Santana, Alisson Rodrigo da Silva Oliveira, Jéssica Carla Bezerra do Nascimento Figueiredo, Isis Torres Souza, Lécio Leone de Almeida, Márcia Vanusa da Silva, Augusto Santos Borges, Jonathan Wagner de Medeiros, Jacinto da Costa Silva Neto, Rita de Cássia Ribeiro Gonçalves, Rodrigo Rezende Kitagawa, Antônio Euzébio Goulart Sant′Ana, Larissa Araújo Rolim, Irwin Rose Alencar de Menezes, Teresinha Gonçalves da Silva, Germana Freire Rocha Caldas, Almir Gonçalves Wanderley Oxidative Medicine and Cellular Longevity, 2018
Anti-edematogenic and anti-inflammatory activity of the essential oil from Croton rhamnifolioides leaves and its major constituent 1,8-cineole (eucalyptol) Anita Oliveira Brito Pereira Bezerra Martins, Lindaiane Bezerra Rodrigues, Francisco Rafael Alves Santana Cesário, Maria Rayane Correia de Oliveira, Cicera Datiane Morais Tintino, Fyama Ferreira e Castro, Isabel Sousa Alcântara, Maria Neyze Martins Fernandes, Thaís Rodrigues de Albuquerque, Maria Sanadia Alexandre da Silva, Adriano Antunes de Sousa Araújo, Lucindo José Quintans Júniur, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley Biomedicine and Pharmacotherapy, 2017
Fern extracts potentiate fluconazole activity and inhibit morphological changes in Candida species Maria A. Freitas, Antonia T.L. Santos, Antonio J.T. Machado, Ana Raquel P. Silva, Fábia F. Campina, Maria S. Costa, Gioconda M.A.B. Martins, Maria Flaviana B. Morais-Braga, Saulo R. Tintino, Irwin R.A. Menezes, Jaime Ribeiro-Filho, Altevir P. Medeiros, Adeliana S. Oliveira, Patrício B. Maracajá, Henrique D.M. Coutinho Asian Pacific Journal of Tropical Biomedicine, 2017
Anti-inflammatory activity of the essential oil obtained from Ocimum basilicum complexed with β-cyclodextrin (β-CD) in mice Lindaiane Bezerra Rodrigues, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro-Filho, Francisco Rafael Alves Santana Cesário, Fyama Ferreira e Castro, Thaís Rodrigues de Albuquerque, Maria Neyze Martins Fernandes, Bruno Anderson Fernandes da Silva, Lucindo José Quintans Júnior, Adriano Antunes de Sousa Araújo, Paula dos Passos Menezes, Paula Santos Nunes, Isabella Gonçalves Matos, Henrique Douglas Melo Coutinho, Almir Goncalves Wanderley, Irwin Rose Alencar de Menezes Food and Chemical Toxicology, 2017
Antibacterial, modulatory activity of antibiotics and toxicity from Rhinella jimi (Stevaux, 2002) (Anura: Bufonidae) glandular secretions Débora Lima Sales, Maria Flaviana Bezerra Morais-Braga, Antonia Thassya Lucas dos Santos, Antonio Judson Targino Machado, João Antonio de Araujo Filho, Diógenes de Queiroz Dias, Francisco Assis Bezerra da Cunha, Rogério de Aquino Saraiva, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José Galberto Martins Costa, Felipe Silva Ferreira, Rômulo Romeu da Nóbrega Alves, Waltécio de Oliveira Almeida Biomedicine and Pharmacotherapy, 2017
Evaluation of the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex Fernanda de Sousa Oliveira, Thiago Sampaio de Freitas, Rafael Pereira da Cruz, Maria do Socorro Costa, Raimundo Luiz Silva Pereira, Lucindo José Quintans-Júnior, Tatianny de Araújo Andrade, Paula dos Passos Menezes, Bruna Maria Hipólito de Sousa, Paula Santos Nunes, Mairim Russo Serafini, Irwin Rose Alencar de Menezes, Adriano Antunes de Souza Araújo, Henrique Douglas Melo Coutinho Biomedicine and Pharmacotherapy, 2017
Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice Cinara Soares Vidal, Anita Oliveira Brito Pereira Bezerra Martins, Andressa de Alencar Silva, Maria Rayane Correia de Oliveira, Jaime Ribeiro-Filho, Thaís Rodrigues de Albuquerque, Henrique Douglas Melo Coutinho, Jackson Roberto Guedes da Silva Almeida, Lucindo Jose Quintans, Irwin Rose Alencar de Menezes Biomedicine and Pharmacotherapy, 2017
Natural products assessed in animal models for orofacial pain – a systematic review Pollyana S. Siqueira-Lima, Juliane C. Silva, Jullyana S.S. Quintans, Angelo R. Antoniolli, Saravanan Shanmugam, Rosana S.S. Barreto, Márcio R.V. Santos, Jackson R.G.S. Almeida, Leonardo R. Bonjardim, Irwin R.A. Menezes, Lucindo J. Quintans-Júnior Revista Brasileira De Farmacognosia, 2017
In vitro modulation of the antibiotic activity of essential oil from fruits of piper tuberculatum jacq Revista Cubana De Plantas Medicinales, 2017
Oxidant effects and toxicity of Croton campestris in Drosophila melanogaster Francisco E. B. Júnior, Giulianna Echeverria Macedo, Ana Paula Zemolin, Gustavo Felipe da Silva, Litiele Cezar da Cruz, Aline Augusti Boligon, Irwin R. A. de Menezes, Jeferson Luis Franco, Thaís Posser Pharmaceutical Biology, 2016
Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats Germana Freire Rocha Caldas, Mayara Marília Ferreira Limeira, Alice Valença Araújo, Giwellington Silva Albuquerque, Jacinto da Costa Silva-Neto, Teresinha Gonçalves da Silva, João Henrique Costa-Silva, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Almir Gonçalves Wanderley Food and Chemical Toxicology, 2016
Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro Patrícia Rosane Leite de Figueiredo, Isabella Bezerra Oliveira, José Benício Santana Neto, Juliana Albuquerque de Oliveira, Larissa Bernardo Ribeiro, Glauce Socorro de Barros Viana, Talita Magalhães Rocha, Luzia Kalyne Almeida Moreira Leal, Marta Regina Kerntopf, Cícero Francisco Bezerra Felipe, Henrique Douglas Melo Coutinho, Irwin Rose de Alencar Menezes Journal of Ethnopharmacology, 2016
Development and physicochemical properties of extract of Morinda citrifolia Linn/pectin-based membranes Josepha Yohanna de Jesus, Eliane Santos de Carvalho Dantas, Mairim Russo Serafini, Paula dos Passos Menezes, Juliana Cordeiro Cardoso, Ricardo Luiz Cavalcanti Albuquerque-Jr, Jivaldo do Rosário Matos, Juliana Ferreira de Oliveira, Irwin Rose Alencar de Menezes, Francilene Amaral da Silva, Adriano Antunes de Souza Araújo Journal of Thermal Analysis and Calorimetry, 2016
Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures Cleide Correia de Oliveira, Clarissa Vasconcelos de Oliveira, Jéssica Grigoletto, Leandro Rodrigo Ribeiro, Vinícius Rafael Funck, Ana Cláudia Beck Grauncke, Thaíze Lopes de Souza, Naieli Schiefelbein Souto, Ana Flávia Furian, Irwin Rose Alencar Menezes, Mauro Schneider Oliveira Epilepsy and Behavior, 2016
Phytochemical Composition, Antifungal and Antioxidant Activity of Duguetia furfuracea A. St.-Hill Francisca Valéria Soares de Araújo Pinho, Litiele Cezar da Cruz, Nathane Rosa Rodrigues, Emily Pansera Waczuk, Celestina Elba Sobral Souza, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Margareth Linde Athayde, Aline Augusti Boligon, Jeferson Luis Franco, Thaís Posser, Irwin Rose Alencar de Menezes Oxidative Medicine and Cellular Longevity, 2016
Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice Elizângela Beneval Bento, Francisco Elizaudo de Brito Júnior, Dayanne Rakelly de Oliveira, Cícera Norma Fernandes, Gyllyandeson de Araújo Delmondes, Francisco Rafael Alves Santana Cesário, Cristina Kelly de Sousa Rodrigues, Valterlúcio dos Santos Sales, Francisco Rodolpho Sobreira Dantas Nóbrega de Figueiredo, Izabel Cristina Santiago Lemos, Álefe Brito Monteiro, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Marta Regina Kerntopf Saudi Journal of Biological Sciences, 2016
Therapeutic traditional practices: Usage and knowledge of cerrado plants in the State of Pernambuco (Northeastern Brazil) Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2015
Silymarin has antioxidant potential and changes the activity of Na+/K+-ATPase and monoamine oxidase in vitro Dayanne Rakelly de Oliveira, Larissa Finger Schaffer, Alcindo Busanello, Caroline Pilecco Barbosa, Luis Ricardo Peroza, Catiuscia Molz de Freitas, Barbara Nunes Krum, Getúlio Nicola Bressan, Aline Augusti Boligon, Margareth Linde Athayde, Irwin Rose Alencar de Menezes, Roselei Fachinetto Industrial Crops and Products, 2015
Medicinal plants in candomblé as element of cultural resistance and health care Revista Cubana De Plantas Medicinales, 2015
Plant species as a therapeutic resource in areas of the savanna in the state of Pernambuco, Northeast Brazil Manuele Eufrasio Saraiva, Ana Vartan Ribeiro de Alencar Ulisses, Daiany Alves Ribeiro, Liana Geraldo Souza de Oliveira, Delmácia Gonçalves de Macêdo, Francisca de Fátima Silva de Sousa, Irwin Rose Alencar de Menezes, Everardo Valadares de Sá Barretto Sampaio, Marta Maria de Almeida Souza Journal of Ethnopharmacology, 2015
Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) Israel J. M. Santos, Gerlânia O. Leite, José Galberto M. Costa, Romulo R. N. Alves, Adriana R. Campos, Irwin R. A. Menezes, Francisco Ronaldo V. Freita, Maria Janeth H. Nunes, Waltécio O. Almeida Evidence Based Complementary and Alternative Medicine, 2015
Ferns as protective agents against the contamination with mercurium chloride: The example of Pityrogramma calomelanos (L.) link and a short review Ferns and Shrubs Diversity Cultivation and Implications for the Environment, 2015
Antimicrobial activity and phytochemical characterization of hydroalcoholic extracts of Passiflora cincinnata mast. (maracujá-do-mato) Revista Cubana De Plantas Medicinales, 2014
Study on the chemical composition and antibacterial activity of Bowdichia virgilioides kunth (Sucupira) - Fabaceae - Papilonoidae Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2014
Gastroprotective and ulcer healing effects of essential oil of Hyptis martiusiibenth. (Lamiaceae) Germana Freire Rocha Caldas, Alisson Rodrigo da Silva Oliveira, Alice Valença Araújo, Dafne Carolina Alves Quixabeira, Jacinto da Costa Silva-Neto, João Henrique Costa-Silva, Irwin Rose Alencar de Menezes, Fabiano Ferreira, Ana Cristina Lima Leite, José Galberto Martins da Costa, Almir Gonçalves Wanderley Plos One, 2014
Emotion and care in the assistance to children with cancer: Perceptions of nursing staff Revista Cubana De Enfermeria, 2014
Topical antinociceptive effect of Vanillosmopsis arborea baker on acute corneal pain in mice Laura Hévila Inocêncio Leite, Gerlânia de Oliveira Leite, Thales Silva Coutinho, Severino Denício Gonçalves de Sousa, Renata Souza Sampaio, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Adriana Rolim Campos Evidence Based Complementary and Alternative Medicine, 2014
Phytochemical constituents and toxicity of duguetia furfuracea hydroalcoholic extract in drosophila melanogaster Francisca Valéria Soares de Araújo Pinho, Gustavo Felipe da Silva, Giulianna Echeverria Macedo, Katiane Raquel Muller, Illana Kemmerich Martins, Ana Paula Lausmann Ternes, José Galberto Martins da Costa, Margareth Linde Athayde, Aline Augusti Boligon, Jean Paul Kamdem, Jeferson Luis Franco, Irwin Rose Alencar de Menezes, Thaís Posser Evidence Based Complementary and Alternative Medicine, 2014
Repeated-doses toxicity study of the essential oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss mice Germana Freire Rocha Caldas, Alice Valença Araújo, Giwellington Silva Albuquerque, Jacinto da Costa Silva-Neto, João Henrique Costa-Silva, Irwin Rose Alencar de Menezes, Ana Cristina Lima Leite, José Galberto Martins da Costa, Almir Gonçalves Wanderley Evidence Based Complementary and Alternative Medicine, 2013
Trypanocide, cytotoxic, and anti-Candida activities of natural products: Hyptis martiusii Benth. Karla K.A. Santos, Edinardo F.F. Matias, Celestina E. Sobral-Souza, Saulo R. Tintino, Maria F.B. Morais-Braga, Gláucia M.M. Guedes, Miriam Rolón, Cathia Coronel, Jorge Alfonso, Celeste Vega, José G.M. Costa, Irwin R.A. Menezes, Henrique D.M. Coutinho European Journal of Integrative Medicine, 2013
Antiulcerogenic activity of the hydroalcoholic extract of leaves of croton campestris a. St.-Hill in rodents Francisco E. B. Júnior, Dayanne R. de Oliveira, Elizângela B. Bento, Laura H. I. Leite, Daniele O. Souza, Ana Luiza A. Siebra, Renata S. Sampaio, Anita O. P. B. Martins, Andreza G. B. Ramos, Saulo R. Tintino, Luiz J. Lacerda-Neto, Patricia R. L. Figueiredo, Larissa R. Oliveira, Cristina K. S. Rodrigues, Valterlúcio S. Sales, Francisco R. S. D. N. Figueiredo, Emmily P. Nascimento, Alefe B. Monteiro, Érika N. Amaro, José G. M. Costa, Henrique Douglas Melo Coutinho, Irwin R. A. de Menezes, Marta R. Kerntopf Evidence Based Complementary and Alternative Medicine, 2013
Modulation of the antibiotic activity by extracts from amburana cearensis A. C. Smith and anadenanthera macrocarpa (Benth.) Brenan Fernando G. Figueredo, Emerson O. Ferreira, Bruno F. F. Lucena, Cícero M. G. Torres, Daniel L. Lucetti, Elaine C. P. Lucetti, João Marcos F. L. Silva, Francisco A. V. Santos, Cássio R. Medeiros, Gardênia M. M. Oliveira, Aracélio V. Colares, José G. M. Costa, Henrique D. M. Coutinho, Irwin R. A. Menezes, Júlio C. F. Silva, Marta R. Kerntopf, Patrícia R. L. Figueiredo, Edinardo F. F. Matias Biomed Research International, 2013
Modulation of the antibiotic activity by the essential oils of origanum vulgare and coriandrum sativum Journal of Food and Nutrition Research, 2013
Antibacterial, antifungal and antimicrobial modulatory activities of fractions from Lygodium venustum SW Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2013
Biological Activities and Chemical Characterization of Cordia verbenacea DC. as Tool to Validate the Ethnobiological Usage Edinardo Fagner Ferreira Matias, Erivânia Ferreira Alves, Beatriz Sousa Santos, Celestina Elba Sobral de Souza, João Victor de Alencar Ferreira, Anne Karyzia Lima Santos de Lavor, Fernando Gomes Figueredo, Luciene Ferreira de Lima, Francisco Antônio Vieira dos Santos, Flórido Sampaio Neves Peixoto, Aracélio Viana Colares, Aline Augusti Boligon, Rogério de Aquino Saraiva, Margareth Linde Athayde, João Batista Teixeira da Rocha, Irwin Rose Alencar Menezes, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa Evidence Based Complementary and Alternative Medicine, 2013
Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L Karla K.A. Santos, Edinardo F.F. Matias, Saulo R. Tintino, Celestina E.S. Souza, Maria F.B.M. Braga, Gláucia M.M. Guedes, Miriam Rolón, Celeste Vega, Antonieta Rojas de Arias, José G.M. Costa, Irwin R.A. Menezes, Henrique D.M. Coutinho Experimental Parasitology, 2012
Anti-Candida activity of Mentha arvensis and Turnera ulmifolia Karla K.A. Santos, Edinardo F.F. Matias, Celestina E.S. Souza, Saulo R. Tintino, Maria F.B.M. Braga, Glaucia M.M. Guedes, Lavouisier F.B. Nogueira, Edson C. Morais, José G.M. Costa, Irwin R.A. Menezes, Henrique D.M. Coutinho Journal of Medicinal Food, 2012
Trypanocide, cytotoxic, and antifungal activities of Momordica charantia Karla K.A. Santos, Edinardo F.F. Matias, Celestina E. Sobral-Souza, Saulo R. Tintino, Maria F.B. Morais-Braga, Glaucia M.M. Guedes, Francisco A.V. Santos, Ana Carla A. Sousa, Miriam Rolón, Celeste Vega, Antonieta Rojas de Arias, José G.M. Costa, Irwin R.A. Menezes, Henrique D.M. Coutinho Pharmaceutical Biology, 2012
Natural products from ethnodirected studies: Revisiting the ethnobiology of the zombie poison Ulysses Paulino Albuquerque, Joabe Gomes Melo, Maria Franco Medeiros, Irwin Rose Menezes, Geraldo Jorge Moura, Ana Carla Asfora El-Deir, Rômulo Romeu Nóbrega Alves, Patrícia Muniz de Medeiros, Thiago Antonio de Sousa Araújo, Marcelo Alves Ramos, Rafael Ricardo Silva, Alyson Luiz Almeida, Cecília de Fátima Castelo Almeida Evidence Based Complementary and Alternative Medicine, 2012
Chemical composition of essential oil of Lantana camara L. (Verbenaceae) and synergistic effect of the aminoglycosides gentamicin and amikacin Records of Natural Products, 2012
Pteridophytes: Ethnobotany and pharmacologic bioactivities Natural Products Structure Bioactivity and Applications, 2012
Evaluation of the anti-Trypanosoma and anti-Leishmania activity of Mentha arvensis and Turnera ulmifolia Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2012
Cytotoxic, trypanocidal, and antifungal activities of Eugenia jambolana L. Karla K.A. dos Santos, Edinardo F.F. Matias, Saulo R. Tintino, Celestina E.S. Souza, Maria F.B.M. Braga, Gláucia M.M. Guedes, Miriam Rolón, Celeste Vega, Antonieta Rojas de Arias, José G.M. Costa, Irwin A. Menezes, Henrique D.M. Coutinho Journal of Medicinal Food, 2012
Cytotoxic and tripanocide activities of pityrogramma calomelanos (L.) link Teogenes M. de Souza, Maria F. B. M. Braga, Rogério A. Saraiva, Pablo A. Nogara, Diones C. Bueno, Aline A. Boligon, Margareth L. A. Fone, João B. T. da Rocha, Miriam Rolon, Celeste Vega, Antonieta Rojas de Arias, Jose G. M. Costa, Irwin R. Alencar de Menezes, Henrique D. M. Coutinho, Antônio A. F. Saraiva American Fern Journal, 2012
Antibacterial and modulatory effect of Stryphnodendron rotundifolium Dayanne R. Oliveira, Francisco E. Brito-Junior, Elizângela B. Bento, Edinardo F.F. Matias, Ana Carla A. Sousa, Jose G.M. Costa, Henrique D.M. Coutinho, Marta R. Kerntopf, Irwin R.A. Menezes Pharmaceutical Biology, 2011
Development of a hierarquical classification algorithm (Winclus) and its application to a indole-2-carboxylate series Revista Brasileira De Ciencias Farmaceuticas Brazilian Journal of Pharmaceutical Sciences, 2001
Automated search for potentially active compounds by using cluster trees Nereide Stela Santos Magalhães, Socrates Cabral De Holanda Cavalcanti, Irwin Rose Alencar De Menezes, Adriano Antunes De Sousa Araújo, Hélio Magalhães De Oliveira, Antonio José Alves European Journal of Medicinal Chemistry, 1999
RECENT SCHOLAR PUBLICATIONS
Targeting oxidative stress and monoamine imbalance: neuroprotective potential of Cereus jamacaru DC ethanolic extract in a Parkinson disease-like model in Drosophila melanogaster RGDS Nunes, YV de Santana Lira, JR de Lima Silva, AR Costa, ... Journal of Toxicology and Environmental Health, Part A 89 (12), 511-533 , 2026 2026
Rhamnazin attenuates Amyloid β-Peptide (1–42) induced spatial memory impairments by modulation of BDNF-ERK signaling pathway S Jabbari, ZA Zakaria, IRA de Menezes, S Mohammadi 3 Biotech 16 (6), 200 , 2026 2026
Neuropharmacological effects of the crude ethanolic extract from aerial parts of Passiflora cincinnata Mast.(Passifloraceae) and possible mechanisms of action involved TLN Goncalves, GA Delmondes, IRA de Menezes, HDM Coutinho, L Picot, ... Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 25 … , 2026 2026
A NOVEL APPROACH FOR ASSESSING ENVIRONMENTAL CONTAMINATION: LINKING ACHE ACTIVITY TO TRACE METALS IN AQUATIC ORGANISMS FJ Gonçalves, RM da Silva Lucas, RM Cavalcante, IRA de Menezes, ... Environmental Research, 124596 , 2026 2026
Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review BAF Silva, MGL Silva, ES Silva, LYS Silva, RT Pessoa, SC Alves‐Júnior, ... Food Frontiers 7 (2), e70228 , 2026 2026
Establishing a Zebrafish ( Danio rerio ) infection model to assess antimicrobial treatment efficacy against Staphylococcus aureus expressing the NorA efflux pump JW Almeida-Bezerra, GG Alencar, LYS da Silva, JE Rocha, FNP Junior, ... Biologia 81 (2), 62 , 2026 2026
Chemical composition, antibiofilm activity, and antibacterial potential in vitro and in a zebrafish model of Myrciaria pilosa Sobral & Couto essential oil RP da Cruz, JW Almeida-Bezerra, DS Alves, ARP da Silva, ... Journal of Ethnopharmacology 354, 120538 , 2026 2026 Citations: 2
Investigation of Phytol as an Inhibitor of the Efflux Pump (QacA/B) in Staphylococcus aureus : in silico and in vitro Studies JW Almeida-Bezerra, CAL Dos Santos, SA Menezes, ... Pharmaceutical Research 43 (1), 269-277 , 2026 2026
Integrated in Vitro, in Vivo, Molecular Docking, and ADMET in Silico Assessment of β-Caryophyllene as a NorA Efflux Pump inhibitor in Resistant Staphylococcus Aureus (MRSA) JW Almeida-Bezerra, JT da Costa Silva, CD de Morais Oliveira-Tintino, ... Current Microbiology 83 (1), 41 , 2026 2026
Mechanisms of Action Involved in the In Vivo Gastroprotective Response of Fruits: A Systematic Review IS Alcântara, RT Pessoa, LYS Silva, TM Silva, IO Menezes, ... Food Frontiers 7 (1), e70117 , 2026 2026
Influence of perillyl alcohol on human umbilical vein relaxation: mechanisms involving calcium channels and protein kinase C CM de Sena Bastos, A de Alencar Silva, PR Batista, MR da Silva Duarte, ... Placenta , 2025 2025
Antibacterial and Antibiotic‐Enhancing Activity of 3‐Hydroxy‐4‐methoxycinnamic Acid: Experimental Data and In Silico Predictions J Thyálisson da Costa Silva, V Bezerra da Silva, G Fernandes Teixeira, ... ChemistrySelect 10 (47), e03548 , 2025 2025
Piper tuberculatum Jacq. essential oil and its impact on the control of Candida spp. and Pichia kudriavzevii: increased efficacy of fluconazole and inhibition of virulence MFB Morais-Braga, VJA Fonseca, JNP Carneiro, ATL Dos Santos, ... Journal of Ethnopharmacology, 120840 , 2025 2025
Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps IA Donato, CRS Barbosa, AH Bezerra, SR Bezerra, RS Almeida, ... Pharmaceuticals 18 (11), 1629 , 2025 2025
RESULTADOS DO TRATAMENTO DA LEUCEMIA MIELOIDE CRÔNICA COM INIBIDORES DE TIROSINOQUINASE EM UM CENTRO PÚBLICO DE REFERÊNCIA NO BRASIL JFS Junior, KM Amaral, AV Coelho, GRO Medeiros, ALV Mion, ... Hematology, Transfusion and Cell Therapy 47, 104456 , 2025 2025
MANEJO DE GESTANTES COM LEUCEMIA MIELOIDE CRÔNICA EM USO DE INIBIDORES DE TIROSINOQUINASE: EXPERIÊNCIA DE UM CENTRO PÚBLICO BRASILEIRO KM Amaral, JFS Junior, AV Coelho, ÉI Guilherme, GRO Medeiros, ... Hematology, Transfusion and Cell Therapy 47, 104440 , 2025 2025
ALTERAÇÕES ÓSSEAS SUBCLÍNICAS ASSOCIADAS AO USO DE INIBIDORES DE TIROSINOQUINASE (ITQ) NA LEUCEMIA MIELOIDE CRÔNICA (LMC): POSSÍVEL ESTÁGIO INTERMEDIÁRIO ANTERIOR À NECROSE ÓSSEA JFS Junior, KM Amaral, AV Coelho, ÉI Guilherme, GO Medeiros, ... Hematology, Transfusion and Cell Therapy 47, 104393 , 2025 2025
MASTOCITOSE SISTÊMICA OU SÍNDROME HIPEREOSINOFÍLICA EM PACIENTE COM SÍNDROME CONSUMPTIVA: UM DESAFIO DIAGNÓSTICO GRO Medeiros, CB LM, I Menezes, VAM Funke, HV Leal, H Borato, ... Hematology, Transfusion and Cell Therapy 47, 104442 , 2025 2025
MASTOCITOSE SISTÊMICA COM ACOMETIMENTO DE TRATO GASTROINTESTINAL EM PACIENTE COM TRIPTASE BAIXA: UM DESAFIO DIAGNÓSTICO E TERAPÊUTICO CB LM, GRO Medeiros, I Menezes, VAM Funke, PSM Mendes, ... Hematology, Transfusion and Cell Therapy 47, 104441 , 2025 2025
Antioxidant and Anti‐Acetylcholinesterase Activities of Three Lippia L. Species: A Chemometric Approach CFA Nonato, EVS de Melo, CJ Camilo, DOD Leite, IRA de Menezes, ... Chemistry & Biodiversity 22 (10), e00914 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Antiedematogenic and anti-inflammatory activity of the monoterpene isopulegol and its β-cyclodextrin (β-CD) inclusion complex in animal inflammation models AGB Ramos, IRA Menezes, MSA da Silva, R Torres Pessoa, ... Foods 9 (5), 630 , 2020 2020 Citations: 2871
Antimicrobial and enhancement of the antibiotic activity by phenolic compounds: Gallic acid, caffeic acid and pyrogallol VN Lima, CDM Oliveira-Tintino, ES Santos, LP Morais, SR Tintino, ... Microbial pathogenesis 99, 56-61 , 2016 2016 Citations: 418
Potencial terapêutico e uso de plantas medicinais em uma área de Caatinga no estado do Ceará, nordeste do Brasil DA Ribeiro, DG Macêdo, LGS Oliveira, ME Saraiva, SF Oliveira, ... Revista brasileira de plantas medicinais 16 (4), 912-930 , 2014 2014 Citations: 203
Biochemical aspects of the inflammatory process: A narrative review CLR Soares, P Wilairatana, LR Silva, PS Moreira, NMMV Barbosa, ... Biomedicine & Pharmacotherapy 168, 115764 , 2023 2023 Citations: 174
Synergistic antibiotic activity of volatile compounds from the essential oil of Lippia sidoides and thymol HNH Veras, FFG Rodrigues, AV Colares, IRA Menezes, HDM Coutinho, ... Fitoterapia 83 (3), 508-512 , 2012 2012 Citations: 172
Seasonal variation of Brazilian red propolis: Antibacterial activity, synergistic effect and phytochemical screening MSR Neto, SR Tintino, ARP da Silva, M do Socorro Costa, AA Boligon, ... Food and Chemical Toxicology 107, 572-580 , 2017 2017 Citations: 163
Topical anti-inflammatory effect of Caryocar coriaceum Wittm.(Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents RA Saraiva, MKA Araruna, RC Oliveira, KDP Menezes, GO Leite, ... Journal of ethnopharmacology 136 (3), 504-510 , 2011 2011 Citations: 162
Phytol, a chlorophyll component, produces antihyperalgesic, anti-inflammatory, and antiarthritic effects: Possible NFκB pathway involvement and reduced levels of the … AMS Carvalho, L Heimfarth, EWM Pereira, FS Oliveira, IRA Menezes, ... Journal of natural products 83 (4), 1107-1117 , 2020 2020 Citations: 160
Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures CC de Oliveira, CV de Oliveira, J Grigoletto, LR Ribeiro, VR Funck, ... Epilepsy & Behavior 56, 26-31 , 2016 2016 Citations: 151
Plant species as a therapeutic resource in areas of the savanna in the state of Pernambuco, Northeast Brazil ME Saraiva, AVR de Alencar Ulisses, DA Ribeiro, LGS de Oliveira, ... Journal of ethnopharmacology 171, 141-153 , 2015 2015 Citations: 139
In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin D Rakelly de Oliveira, S Relison Tintino, MFB Morais Braga, AA Boligon, ... BioMed research international 2015 (1), 292797 , 2015 2015 Citations: 130
Evaluation of the tannic acid inhibitory effect against the NorA efflux pump of Staphylococcus aureus SR Tintino, CDM Oliveira-Tintino, FF Campina, RLP Silva, MS Costa, ... Microbial pathogenesis 97, 9-13 , 2016 2016 Citations: 127
Ethnopharmacology of medicinal plants of carrasco, northeastern Brazil RKD Souza, MAP da Silva, IRA de Menezes, DA Ribeiro, LR Bezerra, ... Journal of Ethnopharmacology 157, 99-104 , 2014 2014 Citations: 127
Ethnopharmacological study of plants sold for therapeutic purposes in public markets in Northeast Brazil VCN Bitu, VCN Bitu, EFF Matias, WP de Lima, A da Costa Portelo, ... Journal of Ethnopharmacology 172, 265-272 , 2015 2015 Citations: 126
Promising medicinal plants for bioprospection in a Cerrado area of Chapada do Araripe, Northeastern Brazil DA Ribeiro, LGS de Oliveira, DG de Macêdo, IRA de Menezes, ... Journal of Ethnopharmacology 155 (3), 1522-1533 , 2014 2014 Citations: 121
Essential oils and their major compounds in the treatment of chronic inflammation: A review of antioxidant potential in preclinical studies and molecular mechanisms ÉM de Lavor, AWC Fernandes, RB de Andrade Teles, AEBP Leal, ... Oxidative medicine and cellular longevity 2018 (1), 6468593 , 2018 2018 Citations: 120
In vitro e in silico evaluation of the inhibition of Staphylococcus aureus efflux pumps by caffeic and gallic acid JFS Dos Santos, SR Tintino, TS de Freitas, FF Campina, IRA Menezes, ... Comparative immunology, microbiology and infectious diseases 57, 22-28 , 2018 2018 Citations: 115
Inhibition of the TetK efflux-pump by the essential oil of Chenopodium ambrosioides L. and α-terpinene against Staphylococcus aureus IS-58 PW Limaverde, FF Campina, FAB da Cunha, FD Crispim, FG Figueredo, ... Food and chemical toxicology 109, 957-961 , 2017 2017 Citations: 113
Phenolic composition and medicinal usage of Psidium guajava Linn.: Antifungal activity or inhibition of virulence? MFB Morais-Braga, JNP Carneiro, AJT Machado, DL Sales, ... Saudi journal of biological sciences 24 (2), 302-313 , 2017 2017 Citations: 111
Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan FG Figueredo, EO Ferreira, BFF Lucena, CMG Torres, DL Lucetti, ... BioMed Research International 2013 (1), 640682 , 2013 2013 Citations: 110
