Safety and efficacy of hormonal therapies used to treat endometriosis in women suffering migraine Umberto Perrone, Fabio Barra, Giulio Evangelisti, Alberto Izzotti, Claudio Gustavino, Andrea Antonelli, Umberto Leone Roberti Maggiore, Simone Ferrero Expert Opinion on Drug Safety, 2026 INTRODUCTION: Hormonal therapy is the cornerstone of long-term endometriosis management, especially for women deferring surgery. In patients with comorbid migraine - a common, disabling condition - therapeutic choices must balance efficacy with neurological and vascular safety. AREAS COVERED: This review summarizes hormonal therapies for endometriosis with a focus on safety in migraineurs. A comprehensive literature search was conducted using MEDLINE, EMBASE, and the Cochrane Library up to March 2025. EXPERT OPINION: Combined hormonal contraceptives (CHCs) and progestins remain first-line options for treating endometriosis-related pain. CHCs are contraindicated in patients with migraine with aura because of the increased risk of ischemic stroke, while their prescription in migraine without aura should be individualized, considering also the fact that evidence in women with concomitant endometriosis is still limited. Progestins generally show better tolerability and may improve migraine outcomes, despite the occurrence of breakthrough bleeding or mood changes. Gonadotropin-releasing hormone (GnRH) agonists and antagonists are second-line options, providing effective pain control, although their effects on migraine are variable and headaches are a frequent adverse event. Add-back therapy is essential to mitigate hypoestrogenic sequelae, particularly about bone health. Overall, treatment should be individualized according to migraine subtype and vascular risk profile to ensure long-term safety, adherence, and therapeutic effectiveness.
Uterine “twisting sign”: A new potential ultrasonographic soft marker for deep endometriosis Fabio Barra, Simone Ferrero, Umberto Perrone, Giulio Evangelisti, Alessandra Pulliero, Alberto Izzotti, Umberto Leone Roberti Maggiore, Stefano Bogliolo International Journal of Gynecology and Obstetrics, 2025 ObjectiveThe objective of the current study was to evaluate the “twisting sign,” defined as uterine fundus rotation observed on transvaginal sonography (TVS), as a potential soft marker for deep endometriosis (DE) and its association with specific DE localizations and indirect signs.MethodsA prospective observational study was conducted at an endometriosis referral center. We enrolled 158 reproductive‐aged women with pelvic pain requiring specialist evaluation. Exclusion criteria included prior endometriosis diagnosis or conditions affecting uterine positioning, such as large myomas, uterine malformations, or previous pelvic surgery. Standardized TVS assessments, following IDEA (International Deep Endometriosis Analysis) criteria, were performed by a single experienced operator. The twisting sign was defined as a uterine rotation angle between 15° and 90° in the fundal transverse section.ResultsThe twisting sign was detected in 24.1% of participants and was significantly associated with posterior compartment DE, particularly rectosigmoid nodules (44.8.7% vs. 14.0%, P < 0.001) and uterosacral ligament involvement (41.4% vs. 23.3%, P = 0.046). It was also linked to indirect DE markers, including ovarian fixation to the uterine wall (37.9% vs. 19.4%, P = 0.031) and absence of the posterior sliding sign (37.9% vs. 9.3%, P < 0.001). Multivariate analysis confirmed the twisting sign as an independent predictor of rectosigmoid junction nodules (odds ratio [OR], 9.84 [95% confidence interval [CI], 1.69–58.83], P = 0.012) and absence of the posterior sliding sign (OR, 6.63 [95% CI, 1.88–24.34], P = 0.004).ConclusionThe twisting sign may represent a novel and potentially valuable ultrasonographic marker of DE, particularly in the posterior pelvic compartment. It likely reflects mechanical distortion of the uterine axis due to DE nodules and adhesions. Multicenter validation is warranted.
Experimental Evaluation of the Efficacy of Air-Sanitizing Equipment in Neutralizing Airborne SARS-CoV-2 Virus Alberto Izzotti, Nicolò Ruzzarin, Oriana Ferrante, Alessandra Pulliero Pathogens, 2025 Air-sanitizing equipment is a collection of protective devices using filtration and/or UV irradiation to entrap aerosol and kill viruses, to prevent the spread of airborne infective diseases in indoor environments. The aim of the herein reported experimental study was to evaluate the possibility of attenuating the environmental spread of the SARS-CoV-2 virus by sanitizing indoor air. Aerosols were generated from human throat swab samples containing viable wild-type SARS-CoV-2. These samples were introduced into a controlled airflow channel and collected in buffered saline, with or without air sanitization. The viral presence was evaluated by antigenic test and qPCR. 34 different types of air- sanitizers were tested for their ability to neutralize viral aerosols. All devices neutralized viral infectivity as evaluated by a antigen test, qPCR, and cell infectivity, except for the unit without filtration and using LED-UV instead of bulbs, which was ineffective at 5 min but effective after 10 min of treatment. The obtained results provide evidence that 97% of the tested sanitizing devices are effective in breaking down the airborne viral load of wild human SARS-CoV-2 virus, even at a very high concentration, with a single passage of air. These results provide evidence that high-quality air-sanitizing devices may be used as a preventive tool to prevent the risk of airborne infections in indoor environments.
Antioxidant Food Supplementation in Cancer: Lessons from Clinical Trials and Insights from Preclinical Studies Alessandra Pulliero, Barbara Marengo, Oriana Ferrante, Zumama Khalid, Stefania Vernazza, Nicolò Ruzzarin, Cinzia Domenicotti, Alberto Izzotti Antioxidants, 2025 Food antioxidant supplementation has been widely proposed for cancer prevention and adjuvant therapy due to the pleiotropic role of antioxidants. Herein, particular attention is given to recent clinical trials based on the use of dietary supplements in cancer patients, both as monotherapy and in combination with standard treatments, exploring both their potential benefits and risks. This review focuses on the efficacy of the most important food antioxidants, highlighting how their action may change depending on different factors such as cancer type, dose, timing of administration and antioxidant status of the patient. The results of clinical trials are often contradictory, and the clinical benefit of dietary antioxidants appears more consistent in patients with a baseline antioxidant deficiency. Furthermore, by analyzing the mechanisms underlying the contradictory clinical evidence and critically addressing the issues related to the methodologies used in preclinical models, this review could be helpful in guiding the personalized use of antioxidant supplementation in cancer patients.
Recent Advances in Amyloids Structural Studies and Thin Film Applications Eugenia Pechkova, Stefano Fiordoro, Alberto Izzotti, Christian Riekel Molecules, 2025 Amyloids are protein-based biomaterials composed of fibrils with cross-β cores. Previously only associated with degenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and diabetes, amyloids remain active and functional both in vivo and in vitro conditions, enabling a variety of applications in medicine, nanotechnology, and biotechnology. This review aims to review the most advanced methods for amyloid fibril structural studies, with special attention on amyloid thin films. Selected advances of biomedical and biotechnological relevance will be outlined, and perspectives for future studies in the context of ongoing methodological progress will be discussed.
Wastewater-Based Surveillance of Human Adenoviruses in Italy: Quantification by Digital PCR and Molecular Typing via Nanopore Amplicon Sequencing Carolina Veneri, G. Bonanno Ferraro, D. Congiu, A. Franco, D. Brandtner, P. Mancini, M. Iaconelli, , L. Lucentini, E. Suffredini, Giuseppina La Rosa Viruses, 2025 Wastewater-based epidemiology (WBE) offers valuable insight into viral circulation at the community level. In this study, we combined digital PCR (dPCR) with molecular typing to investigate the prevalence and diversity of human adenoviruses (HAdVs) in untreated wastewater samples collected throughout Italy. HAdV genomes were detected in over 93% of the 168 samples analyzed, with concentrations up to 4.5 × 106 genome copies per liter. For genotypic characterization, we used nested PCR followed by Sanger and Oxford Nanopore Technologies (ONTs) long-read sequencing. While Sanger sequencing identified three dominant genotypes (HAdV-A12, HAdV-B3, and HAdV-F41), ONT sequencing provided enhanced resolution, confirming all previously identified types and revealing seven additional genotypes: HAdV-B21, HAdV-C5, HAdV-D45, HAdV-D46, HAdV-D49, HAdV-D83, and HAdV-F40. This comprehensive approach highlights the added value of ONT long-read sequencing in uncovering the genetic complexity of adenoviruses in wastewater, particularly in detecting rare or low abundance types that conventional methods may miss. Our findings highlight the value of integrating quantitative and high-resolution molecular tools in WBE to improve surveillance and better understand the epidemiology of viral pathogens circulating in the human population.
Using Natural Isotopes for the Environmental Tracking of a Controlled Landfill Site for Non-Hazardous Waste in Liguria, Italy A. Izzotti, A. Pulliero, Z. Khalid, O. Ferrante, E. Aquilia, S. Sciacca, G. Oliveri Conti, M. Ferrante International Journal of Environmental Research and Public Health, 2025 The application of natural radioisotope and stable isotope tracing represents a novel, sensitive method for confirming the presence of environmental contamination due to leachate water from solid waste landfills. This study aimed to employ this approach to assess the efficiency of containment measures and the potential environmental impact in the vicinity of a landfill designated for non-hazardous waste disposal. We collected leachate water samples from two distinct areas: one currently active, and another exhausted. In February, May, August, and November 2022, we collected deep water samples from a nearby stream utilizing piezometers, both upstream and downstream from the facility. We examined deuterium and tritium radioisotopes via liquid scintillation, and stable isotope oxygen-18 via ratio mass spectrometry. The results revealed the presence of anthropogenic radioisotopes within the landfill, with higher concentrations in the active site. No radioisotopes or stable isotopes above the natural background were identified in any of the samples obtained from outside. The levels of tritium were found to correlate with rainfall in the samples collected inside, but not in those obtained outside. These findings provide evidence of the effectiveness of the active structural, managerial, and procedural containment measures and the absence of environmental contamination stemming from the studied site, reinforcing the value of the responsible management of non-hazardous waste and its limited impact on the surrounding environment. The reported results highlight the utility of performing radioisotope and stable isotope monitoring not only inside but also outside the landfill, and analyzing the relation via pluviometry.
Evaluation of Trends in Influenza A and B Viruses in Wastewater and Human Surveillance Data: Insights from the 2022–2023 Season in Italy P. Mancini, D. Brandtner, C. Veneri, G. Bonanno Ferraro, M. Iaconelli, S. Puzelli, M. Facchini, G. Di Mario, P. Stefanelli, L. Lucentini, A. Muratore, , Paolo Torlontano, Giuseppe Aprea, Silvia Scattolini, Vicdalia Aniela Acciari, Mariangela Mininni, Rosa Anna Cifarelli, Achille Palma, Giuseppe Lauria, Giovanna La Vecchia, Edoardo Malacaria, Giuseppe Folino, Adelaide Calabria, Giorgia Bulotta, Angelo D’Argenzio, Luigi Cossentino, Giovanna Fusco, Maurizio Viscardi, Alessandra Tosco, Amalia Porta, Antonia Voli, Francesca Pennino, Annalisa Lombardi, Paola Angelini, Daniele Nasci, Giovanni Alborali, Nicoletta Formenti, Flavia Guarneri, Nadia Fontani, Marco Guercio, Lisa Gentili, Marika Mariuz, Gabriella Trani, Anna Pariani, Laura De Lellis, Carla Ancona, Alessandra Barca, Flavia Serio, Doriana Antonella Giorgi, Irene Ferrante, Monica Monfrinotti, Maria Teresa Scicluna, Antonella Cersini, Gabriele Pietrella, Claudio Ottaviano, Mariaconcetta Arizzi, Acea Elabori, Elena Nicosia, Nadia Fontani, Marco Guercio, Elena Grasselli, Alberto Izzotti, Irene Tomesani, Marta Bellisomi, Stefano Rosatto, Emanuela Ammoni, Danilo Cereda, Barbara Bertasi, Desdemona Oliva, Maria Giovanna Guiso, Sara Castiglioni, Silvia Schiarea, Sandro Binda, Valeria Primache, Laura Pellegrinelli, Clementina Cocuzza, Andrea Franzetti, Luigi Bolognini, Fabio Filippetti, Marta Paniccia’, Sara Briscolini, Silvia Magi, Annalisa Grucci, Michele Colitti, Angela Ciccaglione, Carmen Montanaro, Giuseppe Aprea, Silvia Scattolini, Vicdalia Aniela Acciari, Bartolomeo Griglio, Angela Costa, Lucia Decastelli, Angelo Romano Manila Bianchi, Elisabetta Carraro, Cristina Pignata, Lisa Richiardi, Silvia Bonetta, Nehludoff Albano, Giuseppe Di Vittorio, Onofrio Mongelli, Francesca Apollonio, Francesco Triggiano, Osvalda De Giglio, Maria Teresa Montagna, Mario Palermo, Carmelo Massimo Maida, Walter Mazzucco, Fabio Tramuto, Simona De Grazia, Giovanni Maurizio Giammanco, Chiara Filizzolo, Giuseppa Purpari, Francesca Gucciardi, Margherita Ferrante, Antonella Agodi, Martina Barchitta, Piergiuseppe Cala, Annalaura Carducci, Marco Verani, Ileana Federigi, Matteo Ramazzotti, Gian Maria Rossolini, Salvatore Macrì, Ermanno Federici, Maya Petricciuolo, Agnese Carnevali, Mauro Ruffier, Lorena Masieri, Eric Grange, Florida Damasco, Francesca Russo, Gisella Pitter, Vanessa Groppi, Franco Rigoli, Marco Zampini, Tatjana Baldovin, Irene Amoruso, Maria Cadonna, Mattia Postinghel, Paola Foladori, Francesca Cutrupi, Alberta Stenico, Demetz Lea, Morelli Marco, Dossena Matteo, E. Suffredini, G. La Rosa Food and Environmental Virology, 2025 Wastewater-based epidemiology (WBE) is a recognized, dynamic approach to monitoring the transmission of pathogens in communities through urban wastewater. This study aimed to detect and quantify influenza A and B viruses in Italian wastewater during the 2022–2023 season (October 2022 to April 2023). A total of 298 wastewater samples were collected from 67 wastewater treatment plants (WTPs) across the country. These samples were analyzed for influenza A and B viruses (IAV, IBV) using primers originally developed by the Centers for Disease Control and Prevention (CDC) for real-time PCR and adapted for digital PCR. The overall detection rates of IAV and IBV across the entire study period were 19.1% and 16.8%, respectively. The prevalence of IAV in wastewater showed a gradual increase from October to December 2022, peaking at 61% in December. In contrast, IBV peaked at 36% in February 2023. This temporal discrepancy in peak concentrations suggests different seasonal patterns for the two influenza types. These trends mirrored human surveillance data, which showed influenza A cases peaking at 46% in late December and declining to around 2% by April 2023, and influenza B cases starting to increase significantly in January 2023 and peaking at about 14% in March. IAV concentrations ranged from 9.80 × 10 2 to 1.94 × 10 5 g.c./L, while IBV concentrations ranged from 1.07 × 10 3 to 1.43 × 10 4 g.c./L. Overall, the environmental data were consistent with the human surveillance trends observed during the study period in the country. These results demonstrate the value of WBE in tracking epidemiological patterns and highlight its potential as a complementary tool to infectious diseases surveillance systems.
The Role of microRNA Expression and DNA Methylation in HPV-Related Cervical Cancer: A Systematic Review Alessandra Pulliero, Giulia Cassatella, Pietro Astuni, Zumama Khalid, Stefano Fiordoro, Alberto Izzotti International Journal of Molecular Sciences, 2024 Human papillomavirus (HPV) infection is a major etiologic factor in cervical cancer, a major cause of cancer-related morbidity and mortality among women worldwide. The role of microRNA (miRNA) dysregulation in cervical carcinogenesis is still largely unknown, but epigenetic changes, including DNA methylation and miRNA regulation, are crucial factors. The integration of HPV DNA into the host genome can lead to alterations in DNA methylation patterns and miRNA expression, contributing to the progression from normal epithelium to cervical intraepithelial neoplasia and, ultimately, to cervical cancer. This review aimed to examine the relationship between epigenetic changes in the development and progression of HPV associated with cervical cancer. A systematic literature search was conducted in major databases using predefined inclusion and exclusion criteria. Studies that investigated the expression, function, and clinical significance of miRNAs, DNA methylation, and the expression of oncoproteins in HPV-related cervical cancer were included. Data extraction, quality assessment, and synthesis were performed to provide a comprehensive overview of the current state of knowledge. We provide an overview of the studies investigating miRNA expression in relation to cervical cancer progression, highlighting their common outcomes and their weaknesses/strengths. To achieve this, we systematically searched the Pubmed database for all articles published between January 2018 and December 2023. Our systematic review revealed a substantial body of evidence supporting the pivotal role of miRNA dysregulation in the pathogenesis of HPV-related cervical cancer and related oncoproteins. From the 28 studies retrieved, miR-124, FAM194/miR-124-2, and DNA methylation are the most frequently down- or up-regulated in CC progression. Notably, FAM194/miR-124-2 and DNA methylation emerged as a promising molecular marker for distinguishing between cases requiring immediate surgical intervention and those amenable to a more conservative wait-and-see approach. This systematic review underscores the critical involvement of microRNA in the context of HPV-related cervical cancer and sheds light on the potential clinical utility of FAM194/miR-124-2 and DNA methylation as a discriminatory tool for guiding treatment decisions. The identification of patients who may benefit from early surgical intervention versus those suitable for observation has important implications for personalized and targeted management strategies in the era of precision medicine.
Tracking the Spread of the BA.2.86 Lineage in Italy Through Wastewater Analysis C. Veneri, D. Brandtner, P. Mancini, G. Bonanno Ferraro, M. Iaconelli, E. Suffredini, M. Petrillo, G. Leoni, V. Paracchini, B. M. Gawlik, A. Marchini, , Paolo Torlontano, Giuseppe Aprea, Silvia Scattolini, Vicdalia Aniela Acciari, Michele La Bianca, Rosa Anna Cifarelli, Achille Palma, Giuseppe Lauria, Giovanna La Vecchia, Vincenzo Giordano, Luigi Cossentino, Francesca Pennino, Annalisa Lombardi, Lisa Gentili, Paola Angelini, Daniele Nasci, Giovanni Alborali, Nicoletta Formenti, Flavia Guarneri, Nadia Fontani, Marco Guercio, Marika Mariuz, Gabriella Trani, Anna Pariani, Laura De Lellis, Carla Ancona, Alessandra Barca, Flavia Serio, Doriana Antonella Giorgi, Irene Ferrante, Valeria Capparuccini, Maria Teresa Scicluna, Antonella Cersini, Gabriele Pietrella, Elena Nicosia, Nadia Fontani, Marco Guercio, Elena Grasselli, Alberto Izzotti, Irene Tomesani, Marta Bellisomi, Stefano Rosatto, Emanuela Ammoni, Danilo Cereda, Barbara Bertasi, Marina Nadia Losio, Desdemona Oliva, Sara Castiglioni, Silvia Schiarea, Sandro Binda, Valeria Primache, Laura Pellegrinelli, Clementina Cocuzza, Rosario Musumeci, Luigi Bolognini, Fabio Filippetti, Marta Paniccia’, Sara Briscolini, Silvia Magi, Annalisa Grucci, Michele Colitti, Angela Ciccaglione, Carmen Montanaro, Bartolomeo Griglio, Angela Costa, Lucia Decastelli, Angelo Romano, Manila Bianchi, Elisabetta Carraro, Cristina Pignata, Manuela Macrì, Silvia Bonetta, Nehludoff Albano, Giuseppe Di Vittorio, Onofrio Mongelli, Francesca Apollonio, Francesco Triggiano, Osvalda De Giglio, Maria Teresa Montagna, Mario Palermo, Carmelo Massimo Maida, Walter Mazzucco, Fabio Tramuto, Simona De Grazia, Giovanni Maurizio Giammanco, Chiara Filizzolo, Giuseppa Purpari, Francesca Gucciardi, Margherita Ferrante, Antonella Agodi, Martina Barchitta, Piergiuseppe Cala’, Annalaura Carducci, Marco Verani, Ileana Federigi, Salvatore Macrì, Ermanno Federici, Maya Petricciuolo, Agnese Carnevali, Francesca Russo, Gisella Pitter, Vanessa Groppi, Franco Rigoli, Marco Zampini, Tatjana Baldovin, Irene Amoruso, Maria Cadonna, Mattia Postinghel, Paola Foladori, Lorella Zago, Alberta Stenico, Morelli Marco, Dossena Matteo, G. La Rosa Food and Environmental Virology, 2024
Endometrioma surgery: Hit with your best shot (But know when to stop) Umberto Perrone, Simone Ferrero, Irene Gazzo, Alberto Izzotti, Umberto Leone Roberti Maggiore, Claudio Gustavino, Marcello Ceccaroni, Stefano Bogliolo, Fabio Barra Best Practice and Research Clinical Obstetrics and Gynaecology, 2024
Current Medical Therapy for Adenomyosis: From Bench to Bedside Andrea Etrusco, Fabio Barra, Vito Chiantera, Simone Ferrero, Stefano Bogliolo, Giulio Evangelisti, Engin Oral, Mariana Pastore, Alberto Izzotti, Renato Venezia, Marcello Ceccaroni, Antonio Simone Laganà Drugs, 2023
Wastewater surveillance of SARS-CoV-2 variants in October–November 2022 in Italy: detection of XBB.1, BA.2.75 and rapid spread of the BQ.1 lineage G. La Rosa, D. Brandtner, G. Bonanno Ferraro, C. Veneri, P. Mancini, M. Iaconelli, L. Lucentini, C. Del Giudice, L. Orlandi, E. Suffredini, Achille Palma, Adelaide Calabria, Agnese Carnevali, Albano Nehludoff, Alberta Stenico, Alberto Izzotti, Alessandra Barca, Alessandra Tosco, Amalia Porta, Annalisa Lombardi, Antonia Voli, Andrea Franzetti, Angela Ciccaglione, Angela Costa, Angelo D’Argenzio, Angelo Romano, Anna Pariani, Annalaura Carducci, Annalisa Grucci, Anna-Maria Prast, Antonella Agodi, Antonella Cersini, Antonella Giorgi, Barbara Bertasi, Bartolomeo Griglio, Carla Ancona, Carmelo Massimo Maida, Carmen Montanaro, Chiara Filizzolo, Claudio Ottaviano, Clementina Cocuzza, Cristina Pignata, Daniele Nasci, Danilo Cereda, Desdemona Oliva, Doriana Antonella Giorgi, Edoardo Malacaria, Elena Grasselli, Elena Nicosia, Elisabetta Carraro, Emanuela Ammoni, Eric Grange, Ermanno Federici, Fabio Filippetti, Fabio Tramuto, Flavia Guarneri, Flavia Serio, Florida Damasco, Franca Palumbo, Francesca Apollonio, Francesca Cutrupi, Francesca Gucciardi, Francesca Pennino, Francesca Russo, Francesco Triggiano, Franco Rigoli, Gabriele Pietrella, Gabriella Trani, Gian Maria Rossolini, Giorgia Bulotta, Giovanna Fusco, Giovanna La Vecchia, Giovanni Alborali, Giovanni Giammanco, Giovanni Santoro, Gisella Pitter, Giuseppa Purpari, Giuseppe Aprea, Giuseppe Di Vittorio, Giuseppe Folino, Giuseppe Lauria, Ileana Federigi, Irene Amoruso, Irene Ferrante, Irene Tomesani, Laura De Lellis, Laura Pellegrinelli, Lea Demetz, Lisa Gentili, Lisa Richiardi, Lorella Zago, Lorena Masieri, Lucia Decastelli, Luigi Bolognini, Luigi Cossentino, Manila Bianchi, Marco Verani, Marco Zampini, Margherita Ferrante, Maria Cadonna, Maria Teresa Montagna, Maria Teresa Scicluna, Mariaconcetta Arizzi, Marika Mariuz, Mario Palermo, Marta Bellisomi, Marta Paniccià, Martina Barchitta, Matteo Ramazzotti, Mattia Postinghel, Maurizio Viscardi, Mauro Ruffier, Maya Petricciuolo, Michele La Bianca, Michele Colitti, Monica Monfrinotti, Nadia Fontani, Nicoletta Formenti, Onofrio Mongelli, Osvalda De Giglio, Paola Angelini, Paola Foladori, Paolo Torlontano, Piergiuseppe Calà, Rosa Anna Cifarelli, Sandro Binda, Sara Briscolini, Sara Castiglioni, Silvia Bonetta, Silvia Magi, Silvia Scattolini, Silvia Schiarea, Simona De Grazia, Stefano Rosatto, Tatjana Baldovin, Valeria Primache, Vanessa Groppi, Vicdalia Aniela Acciari, Walter Mazzucco Science of the Total Environment, 2023
Pro-environmental behaviors: Determinants and obstacles among italian university students Annalaura Carducci, Maria Fiore, Antonio Azara, Guglielmo Bonaccorsi, Martina Bortoletto, Giuseppina Caggiano, Andrea Calamusa, Antonella De Donno, Osvalda De Giglio, Marco Dettori, Pamela Di Giovanni, Angela Di Pietro, Alessio Facciolà, Ileana Federigi, Iolanda Grappasonni, Alberto Izzotti, Giovanni Libralato, Chiara Lorini, Maria Teresa Montagna, Liberata Keti Nicolosi, Grazia Paladino, Giacomo Palomba, Fabio Petrelli, Tiziana Schilirò, Stefania Scuri, Francesca Serio, Marina Tesauro, Marco Verani, Marco Vinceti, Federica Violi, Margherita Ferrante International Journal of Environmental Research and Public Health, 2021
Prevention of covid-19 infection and related complications by ozonized oils Alberto Izzotti, Enzo Fracchia, William Au, Monica Colombo, Ulrich Pfeffer, Laura Emionite, Simone Pavan, Daniele Miotto, Paola Lova, Elena Grasselli, Emanuela Faelli, Ruggeri Piero, Micaela Tiso, Alessandra Pulliero Journal of Personalized Medicine, 2021
Precision medicine and public health: New challenges for effective and sustainable health Deborah Traversi, Alessandra Pulliero, Alberto Izzotti, Elena Franchitti, Licia Iacoviello, Francesco Gianfagna, Alessandro Gialluisi, Benedetta Izzi, Antonella Agodi, Martina Barchitta, Giovanna Elisa Calabrò, Ilda Hoxhaj, Michele Sassano, Luca Gino Sbrogiò, Annamaria Del Sole, Francesco Marchiori, Erica Pitini, Giuseppe Migliara, Carolina Marzuillo, Corrado De Vito, Manuela Tamburro, Michela Lucia Sammarco, Giancarlo Ripabelli, Paolo Villari, Stefania Boccia Journal of Personalized Medicine, 2021
Impact of the environment on the health: From theory to practice A.L. Carducci, A. Agodi, C. Ancona, P. Angelini, F. Bagordo, F. Barbone, L. Birbaum, V. Carreri, A. Casuccio, A. Conti, M. Conversano, A. De Donno, O. De Giglio, F. Desiante, A. Di Pietro, E. Dogliotti, F. Donato, G.M. Fara, M. Fiore, F. Forastiere, G. Giammanco, A. Izzotti, M.T. Montagna, G. Oliveri Conti, M.G. Petronio, S. Sciacca, C. Signorelli, E. Testai, M. Verani, M. Vinceti, F. Vitale, M. Ferrante, G. Adani, L. Berghella, C. Calia, R. Calzolari, A. Canale, D. Castiglione, A. Conti, C. Copat, A. Cristaldi, G. Cuffari, G. Coronel Vargas, E. De Vita, F. De Nard, I. Federigi, T. Filippini, A. Grasso, N. Leonardi, M. Letzgus, G. Lo Bianco, W. Mazzucco, I. Nicolosi, P. Orlandi, G. Paladino, S. Pizzo, C. Pousis, M. Raffo, S. Rivolta, F. Scarpitta, G. Trani, F. Triggiano, A. Tumbarello, V. Vecchio, P. Zuccarello, M. Vassallo Environmental Research, 2021
Potential role of mirnas in the acquisition of chemoresistance in neuroblastoma Barbara Marengo, Alessandra Pulliero, Maria Valeria Corrias, Riccardo Leardi, Emanuele Farinini, Gilberto Fronza, Paola Menichini, Paola Monti, Lorenzo Monteleone, Giulia Elda Valenti, Andrea Speciale, Patrizia Perri, Francesca Madia, Alberto Izzotti, Cinzia Domenicotti Journal of Personalized Medicine, 2021
Radon biomonitoring and microrna in lung cancer Rakhmet Bersimbaev, Alessandra Pulliero, Olga Bulgakova, Assiya Kussainova, Akmara Aripova, Alberto Izzotti International Journal of Molecular Sciences, 2020
Environment and health: Risk perception and its determinants among Italian university students Annalaura Carducci, Maria Fiore, Antonio Azara, Guglielmo Bonaccorsi, Martina Bortoletto, Giuseppina Caggiano, Andrea Calamusa, Antonella De Donno, Osvalda De Giglio, Marco Dettori, Pamela Di Giovanni, Angela Di Pietro, Alessio Facciolà, Ileana Federigi, Iolanda Grappasonni, Alberto Izzotti, Giovanni Libralato, Chiara Lorini, Maria Teresa Montagna, Liberata Keti Nicolosi, Grazia Paladino, Giacomo Palomba, Fabio Petrelli, Tiziana Schilirò, Stefania Scuri, Francesca Serio, Marina Tesauro, Marco Verani, Marco Vinceti, Federica Violi, Margherita Ferrante Science of the Total Environment, 2019
A Global MicroRNA Profile in Fanconi Anemia: A Pilot Study Paolo Degan, Enrico Cappelli, MariaGrazia Longobardi, Alessandra Pulliero, Paola Cuccarolo, Carlo Dufour, Silvia Ravera, Daniela Calzia, Alberto Izzotti Metabolic Syndrome and Related Disorders, 2019
Modulation of apoptosis by cancer chemopreventive agents Francesco D’Agostini, Alberto Izzotti, Roumen M. Balansky, Carlo Bennicelli, Silvio De Flora Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis, 2005
Erratum: Effects of oral administration of N-acefyl-L-cysteine: A multi-biomarker study in smokers (Cancer Epidemiology, Biomakers and Prevention (February 2002) 11 (167-175)) Cancer Epidemiology Biomarkers and Prevention, 2005
PAHs exposure, urinary 1-pyrenol and DNA adducts among populations living at different distance from an Italian steel plant Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 2003
Patterns of DNA adduct formation in liver and mammary epithelial cells of rats treated with 7,12-dimethylbenz(a)anthracene, and selective effects of chemopreventive agents Cancer Research, 1999
Molecular epidemiology in the identification of subjects susceptible to the effects of environmental carcinogens Annali Di Igiene Medicina Preventiva E Di Comunita, 1999
The toxicology and prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. II. Toxicology. Exposure assessment. Environmental and biological monitoring Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 1997
The toxicology and prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. I. Guide lines for the prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. Società Italiana Valori di Riferimento and Cattedra di Medicina del Lavoro, Università di Brescia Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 1997
Induction by carcinogens and chemoprevention by N-acetylcysteine of adducts to mitochondrial DNA in rat organs Cancer Research, 1996
Biomarker alterations produced in rat lung by intratracheal instillations of air particulate extracts and chemoprevention with oral N-acetylcysteine Cancer Research, 1996
Adducts to nuclear DNA and mitochondrial DNA as biomarkers in chemoprevention. IARC Scientific Publications, 1996
Research on adducts of benzo(a)pyrene and DNA in different cells using synchronous fluorescence spectrophotometry Bollettino Della Societa Italiana Di Biologia Sperimentale, 1991
