Ines Ruedas Torres
Verified @ucm.es
Scopus Publications
- Protective immunity in hamsters from an oral Nipah vaccine correlates with pseudovirus neutralising antibody titre
Meredith Stewart, Peter Bone, Andrew Bacon, Golnaz Emami, Lauren Cave, Elliot J. Bland, Stuart Dowall, Linda Easterbrook, Stephen Findlay-Wilson, Susan Fotheringham, Emma Kennedy, Ines Ruedas-Torres, Francisco J. Salguero, Craig Laferriere, Jeff Drew
Scientific Reports, 2026
Nipah virus (NiV) is a deadly zoonotic pathogen with a high mortality rate and no approved vaccines, creating an urgent need for new solutions. We developed a novel, thermostable, orally administered NiV vaccine using a human serotype 5 adenovirus (AdHu5) vector to express NiV glycoproteins G and F. This vaccine, delivered via an enteric-coated capsule using the OraPro platform, eliminates the cold chain and allows for self-administration. In a Syrian hamster model, a prime-and-pull strategy—an intramuscular prime followed by an oral booster—provided 100% protection against a lethal NiV challenge, significantly outperforming intramuscular administration alone, which offered only 66% protection. The oral booster also led to higher serum neutralizing antibody titres while reducing anti-vector immunity, potentially enabling repeated use of the same vector. Histopathological analysis showed superior protection in orally boosted animals, with minimal lung lesions. This study highlights the potential of oral vaccines for addressing emerging infectious diseases. - A hyperimmune ovine antibody-based therapeutic candidate against Crimean–Congo haemorrhagic fever virus targeted to the Gn and Gc glycoproteins: high antibody levels with neutralization activity but lack of protective efficacy in a mouse model
Emma Kennedy, Stephen Findlay-Wilson, Sarah Webster, Annahita Rajabzadeh, Susan Fotheringham, Linda Easterbrook, Adam Chambers, Mine Aksular, Robert Possee, Sandra Smith, Neville Pope, Aled Griffiths, Ulrike Arnold, David Jackson, Inés Ruedas-Torres, Francisco Javier Salguero, Stuart Dowall
Antibody Therapeutics, 2026
Background Crimean–Congo haemorrhagic fever virus (CCHFV) is a tick-borne pathogen that has a wide geographical range and has the potential to cause severe disease in those infected. There are no currently approved vaccines or therapeutics, so the development and assessment of new approaches are urgently required. Methods A polyclonal antibody-based therapeutic was developed based on immunization of sheep with the major glycoprotein antigens from CCHFV. Along with purified immunoglobulin G (IgG) from hyperimmune sera, fragmentation of the F(ab’)2 region was also performed. The pharmacokinetic properties were assessed in mice, and efficacy was ascertained in a live CCHFV challenge model. Results Candidate polyclonal antibody-based therapies were developed, demonstrating strong binding to the CCHFV envelope glycoprotein and neutralizing activity. The ovine whole IgG demonstrated stability post-delivery compared to a rapid reduction of the F(ab’)2 fragment in the circulation. Efficacy testing when delivered either as a single dose before challenge or as daily dosing for 7 days starting on the day of challenge showed no demonstrable evidence of protection against infection. Conclusions Despite protection observed from vaccine candidates using the CCHFV glycoprotein as an antigen and administration of convalescent sera, the ovine antibody-based therapeutics did not confer similar efficacious effects in the mouse preclinical model. - Histopathological and immunohistochemical characterization of lesions in the golden Syrian hamster model of Nipah virus infection (Bangladesh strain)
Kirsty Swan, Francisco Javier Salguero, Alison Bird, Laura Hunter, Chelsea Kennard, Stephen Findlay-Wilson, Emma Kennedy, Sarah Kempster, Neil Almond, Stuart Dowall, Inés Ruedas-Torres
Frontiers in Veterinary Science, 2026
Nipah virus (NiV) is recognised as a priority pathogen with pandemic potential by the World Health Organisation (WHO). The NiV-Bangladesh strain (NiV-B) has been associated with recent outbreaks in different districts of Bangladesh and the state of Kerala (India), and it is suggested to be more pathogenic and lethal than the NiV-Malaysian strain (NiV-M). In this study, we aimed to describe the clinical signs and pathology of NiV-B using the golden Syrian hamster model following intranasal (IN) and intraperitoneal (IP) inoculation with different doses and to compare with prior NiV-M results. For this purpose, we selected samples from NiV-B-infected animals that were submitted for H&E evaluation, immunohistochemistry (IHC), in situ hybridisation (ISH) (RNAscope technique), and multiplex immunofluorescence (mIF). The absence of neurological signs was observed in NiV-B-infected animals compared with those that were NiV-M-infected. Except for the brain, which did show only mild lesions, histopathological analysis of NiV-B demonstrated similar pathology and viral RNA in the lung, spleen, and liver compared to those of NiV-M infected animals, with the lung being the main affected organ. Pulmonary lesions consisted of areas of broncho-interstitial pneumonia associated with high cell death activation (caspase-3), proliferation (Ki67), and abundant intralesional macrophages (Iba1) and T cells (CD3). Differential upregulation of the cytokine IL-6 was observed in the lung from NiV-B compared with NiV-M infected animals. Moreover, we demonstrated the wide distribution of the NiV receptor ephrin B2 in endothelial cells, neurons, smooth muscle, epithelial cells, macrophages/type II pneumocytes, and T cells. - Periweaning failure to thrive syndrome (PFTS): A growing concern in swine health
Macarena Rodríguez-Ruiz, Librado Carrasco, Inés Ruedas-Torres, José M. Sánchez-Carvajal, Karola Fristiková, Carmen Álvarez-Delgado, Irene M. Rodríguez-Gómez, Jaime Gómez-Laguna, Francisco J. Pallarés
Porcine Health Management, 2025
Background Porcine Periweaning Failure to Thrive syndrome (PFTS) is a complex and scarcely investigated syndrome that has been of increasing concern in the swine industry during the last decade. Its aetiology is believed to be multifactorial, and although both infectious and non-infectious factors may be involved, including a possible genetic predisposition, consistent association needs to be elucidated. Main Body PFTS is characterised by growth retardation and non-specific clinical symptoms that may include progressive debilitation of weaned pigs that typically emerge within two to three weeks after weaning and repetitive oral behaviour such as chomping and licking. Currently, the diagnosis of the syndrome is based on gross examination, where the main observation is a thymus severely atrophic and the gastrointestinal tract empty, and the following characteristic histologic lesions: thymic atrophy, superficial lymphoplasmacytic fundic gastritis, villus atrophy in the small intestine, superficial colitis, lymphocytic and neutrophilic rhinitis, and mild nonsuppurative meningoencephalitis. Research on PFTS has explored various factors contributing to the syndrome, including viral agents, genetic predisposition, and nutritional deficiencies. Studies have identified potential infectious agents, but the definitive association with the syndrome remains unclear. Genetic predisposition has also been suggested to play a role during PFTS, identifying potential boars to individually contribute to PFTS and paternity tests have linked affected piglets to certain boars, suggesting individual susceptibility. In this review, we will explore the contributing factors which may be involved in the development of the syndrome, as well as examine the current knowledge on its diagnosis and pathogenesis. Conclusion PFTS presents a significant challenge in the swine industry due the unknown aetiology and the difficulty to establish an appropriate diagnosis of the syndrome. Therefore, additional research is needed to investigate the microbial, genetic, and environmental factors that influence PFTS, as this is crucial for developing targeted control measures and potential treatments. - Characterisation of lung cell infiltration during the early stage of infection by porcine reproductive and respiratory syndrome virus type 1 strains of different virulence
Karola Fristiková, José María Sánchez-Carvajal, Carmen Álvarez-Delgado, Fernanda Larenas-Muñoz, Macarena Rodríguez-Ruiz, Inés Ruedas-Torres, Inmaculada Barranco, Francisco Javier Salguero, Francisco José Pallarés, Enric Mateu, Librado Carrasco, Irene Magdalena Rodríguez-Gómez, Jaime Gómez-Laguna
Veterinary Microbiology, 2025 - Pathology and host-pathogen interactions in a golden Syrian hamster model of Nipah virus infection
Inés Ruedas-Torres, Stephen Findlay-Wilson, Emma Kennedy, Stuart Dowall, Francisco Javier Salguero
Frontiers in Veterinary Science, 2025
Nipah virus (NiV) is recognized as one of the key pathogens with pandemic potential. We have recently established a NiV hamster model, which reproduces a highly similar disease to that observed in human cases, including respiratory and neurological signs and lesions. The aims of this study were to describe the microscopic lesions observed in the golden Syrian hamster model after intranasal (IN) and intraperitoneal (IP) inoculation with different doses of the Malaysian strain of NiV; to describe in depth the cell composition of the pulmonary and the brain lesions and the expression of proinflammatory cytokines in-situ using a combination of histopathological techniques including immunohistochemistry (IHC) and in-situ hybridisation (ISH) via RNAscope technique. We also developed a multiplex IHC which will allow us to study the interaction of the virus with cell populations in the lung and brain in future studies. For this, we selected 28 lung and brain formalin-fixed paraffin-embedded (FFPE) samples from previous experiments performed by our research group. Histopathology revealed severe pulmonary broncho-interstitial pneumonia, mainly in animals inoculated via the IN route, accompanied by a strong acute inflammatory response (Iba1+ cells) and high levels of NiV RNA. Upregulation of proinflammatory cytokines (IL-6 and TNF) was also observed by ISH RNAscope technique in these animals. Neurological lesions, consisting of perivascular cuffing and meningitis, were observed mainly in animals inoculated via IP route. IHC results showed astrocytosis (GFAP+) and microgliosis (Iba1+) in the brain of these animals, together with mild levels of IL6 and TNF mRNA. These results have helped us to characterize the host-pathogen interaction in the golden Syrian hamster animal model of NiV infection that is being currently used in preclinical testing of antiviral and vaccine strategies. Techniques used in this study could be applied to the development and application of golden Syrian hamster models of other infections by henipaviruses, including Hendra virus (HeV), and other high consequence priority pathogens. - Histological and immunohistochemical characterization of granulomas in alpacas (Vicugna pacos) naturally infected with tuberculosis
Irene Agulló-Ros, Inés Ruedas-Torres, Laura Hunter, Alison Bird, Claire E. Whitehead, Francisco J. Salguero
Frontiers in Veterinary Science, 2025
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC), is a chronic zoonotic disease of increasing concern in alpacas (Vicugna pacos), a species highly susceptible to the disease. Given the growing alpaca population in Europe and zoonotic potential, understanding TB pathology in alpacas is crucial. This study provides the first comprehensive histopathological and immunohistochemical characterization of TB lesions in naturally infected alpacas. Granulomas from the lungs (n = 175), liver (n = 241), and lymph nodes (n = 55), were classified into four developmental stages (I, II, III and IV) based on their morphology, necrosis, fibrosis, cellular composition, and presence of acid-fast bacilli (AFBs). Advanced granulomas (stages III and IV) predominated in all tissues, indicating chronic infection. High numbers of AFBs were observed in lung and lymph node granulomas across all stages, with very rare presence of multinucleated giant cells (MNGCs). This pattern in the lung, with extensive necrosis and lack of fibrous encapsulation, together with the presence of abundant AFBs, suggests deficient immune control and significant transmission risk. In contrast, liver granulomas, particularly encapsulated stage IV lesions, showed fewer detectable AFBs, implying better mycobacterial control in this organ. Immunohistochemistry in selected granulomas revealed ionized calcium-binding adaptor protecin (IBA1) immunopositive macrophages were most prevalent cells in early stages (stage I and II), while T (CD3+) and B lymphocytes (B-cell specific activator protecin+) increased in advanced (stage III and IV) granulomas, forming peripheral lymphoid follicle-like structures. Neutrophils (immunopositive to myeloperoxidase) were less abundant, but more prominent in advanced lesions showing extensive necrosis. The high incidence of liver lesions suggests high dissemination of pathogenic mycobacteria and generalized tuberculosis in this species. This research fills knowledge gaps about tuberculous granulomas in camelids and highlights alpacas as potential sources of mycobacterial excretion, posing a transmission risk to domestic animals, wildlife, and humans. - Cross-protectivity of henipavirus soluble glycoprotein in an in vivo model of Nipah virus disease
Stephen Findlay-Wilson, Nazia Thakur, Lucy Crossley, Linda Easterbrook, Francisco J. Salguero, Ines Ruedas-Torres, Susan Fotheringham, Emma Kennedy, Dalan Bailey, Stuart Dowall
Frontiers in Immunology, 2025
IntroductionNipah virus (NiV) is one of a group of highly pathogenic viruses classified within the Henipavirus genus. Since 2012 at least 11 new henipa-like viruses have been identified, including from new locations and reservoir hosts; the pathogenicity of these new viruses has yet to be determined, but two of them have been associated with morbidity, including fatalities.MethodsThe efficacy and cross-reactivity of two vaccine candidates derived from the soluble glycoproteins of both NiV and Hendra virus (HeV) was evaluated in our recently established hamster model.ResultsBoth vaccine preparations resulted in strong humoral responses against NiV antigenic targets, demonstrating cross-reactive immunity. Efficacy was determined through challenge of hamsters with NiV Malaysian (NiV-M) strain. 100% of the hamsters survived a lethal challenge dose after prime/boost immunisation with glycoproteins derived from both NiV and HeV in the presence of adjuvant, with clinical signs and pathology being significantly reduced in immunised animals.DiscussionThis is first time the NiV and HeV soluble glycoproteins have been compared in the NiV-M hamster challenge model in the presence of Alhydrogel and AddaVax, providing evidence that glycoproteins from closely related henipavirus species can provide cross-protectivity against infection from alternate henipaviruses, supporting the potential of an effective pan-henipavirus vaccine for use in a frontline outbreak response. - Safety and immunomodulatory efficacy of heat-killed Mycolicibacterium manresensis as a novel paraprobiotic in swine
Carmen Álvarez-Delgado, Inés Ruedas-Torres, José M. Sánchez-Carvajal, Karola Fristiková, Macarena Rodríguez-Ruiz, Fernanda Larenas-Muñoz, José J. Cerón, Francisco J. Pallarés, Pere J. Cardona, Irene M. Rodríguez-Gómez, Librado Carrasco, Jaime Gómez-Laguna
Frontiers in Veterinary Science, 2025
Given the increasing global concern about antimicrobial resistance, it is necessary to identify nutritional alternatives to antibiotics and trace elements in the porcine industry. The present study was carried out to evaluate the safety and effect of the paraprobiotic heat-killed Mycolicibacterium manresensis (hkMm) in weaned piglets. For this purpose, twenty-four-week-old piglets, were assigned to four experimental groups, and the diet of three of them was supplemented with 10, 50 and 100 ppm of hkMm, respectively, during a period of 70 d. Animals were monitored throughout the experiment, and weight data, blood, serum and saliva samples were collected every 2 weeks. At the end of the study, tissue samples were collected for histopathology, histomorphometry, immunohistochemical, and gene expression analyses. Supplemented animals did not show any adverse effects neither significant changes in their production parameters. Piglets supplemented with higher doses of hkMm exhibited a significant increase in salivary adenosine deaminase levels (p = 0.0042), along with a significant decrease in serum haptoglobin concentration (p = 0.0263). HkMm also appeared to induce a mild increase in circulating leukocyte populations at the end of the study, primarily due to elevated neutrophil counts, with smaller increases in lymphocytes and monocytes. Additionally, treated animals showed an increase in the number of regulatory T cells (FOXP3⁺) by immunohistochemistry, along with an increased IFNG response by RT-qPCR. Flow cytometry analysis in PBMC showed a decrease in the frequency of CD8β+ T cells (p = 0.0021), together with a higher number of γδ+ T cells in the treated animals throughout the study (p = 0.0327). On the other hand, histomorphometry analysis revealed a significant increase in mucosal height (p = 0.0195) and crypt depth (p = 0.0277) in the intestine of piglets receiving higher doses of hkMm. These results indicate that hkMm is a safe paraprobiotic with immunomodulatory potential, capable of enhancing intestinal integrity and absorptive capacity in weaned piglets, supporting its potential as a nutritional strategy to enhance gut health and reduce reliance on antimicrobial agents. Nevertheless, further studies in animals subjected to a challenge would be valuable to assess hkMm’s efficacy under immunological stress. - Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas
Egidijus Simoliunas, Inés Ruedas-Torres, Yolanda Jiménez-Gómez, Elle Edin, Mozhgan Aghajanzadeh-Kiyaseh, Mostafa Zamani-Roudbaraki, Rimvydas Asoklis, Milda Alksne, Neethi C. Thathapudi, Bijay K. Poudel, Ieva Rinkunaite, Kasparas Asoklis, Monika Iesmantaite, Laura Ortega-Llamas, Almantas Makselis, Marcelo Munoz, Daiva Baltriukiene, Virginija Bukelskiene, Jaime Gómez-Laguna, Miguel González-Andrades, May Griffith
Npj Regenerative Medicine, 2024
Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness. We developed an injectable Cornea-in-a-Syringe (CIS) sealant-filler to treat damaged corneas. CIS comprises linear carboxylated polymers of inflammation-suppressing 2-methacryloyloxyethyl phosphorylcholine, regeneration-promoting collagen-like peptide, and adhesive collagen-citrate glue. We also incorporated GF19, a modified anti-viral host defense peptide that blocked HSV-1 activity in vitro when released from silica nanoparticles (SiNP-GF19). CIS alone suppressed inflammation when tested in a surgically perforated and HSV-1-infected rabbit corneal model, allowing tissue and nerve regeneration. However, at six months post-operation, only regenerated neocorneas previously treated with CIS with SiNP-GF19 had structural and functional features approaching those of normal healthy corneas and were HSV-1 virus-free. We showed that composite injectable biomaterials can be designed to allow regeneration by modulating inflammation and blocking viral activity in an infected tissue. Future iterations could be optimized for clinical application. - Macrophage polarization in lymph node granulomas from cattle and pigs naturally infected with Mycobacterium tuberculosis complex
Fernanda Larenas-Muñoz, Mohamed G. Hamed, Inés Ruedas-Torres, José María Sánchez-Carvajal, Javier Domínguez, Francisco José Pallarés, Librado Carrasco, Irene M. Rodríguez-Gómez, Jaime Gómez-Laguna
Veterinary Pathology, 2024 - Pathological and immunohistochemical assessment of the impact of three different strains of swine enteric coronaviruses in the intestinal barrier
I. Ruedas-Torres, H. Puente, K. Fristikova, H. Argüello, F.J. Salguero, A. Carvajal, J. Gómez-Laguna
Veterinary Microbiology, 2024 - Pathogenicity and virulence of African swine fever virus
Ines Ruedas-Torres, Bui Thi to Nga, Francisco J. Salguero
Virulence, 2024 - The scene of lung pathology during PRRSV-1 infection
Inés Ruedas-Torres, José María Sánchez-Carvajal, Francisco Javier Salguero, Francisco José Pallarés, Librado Carrasco, Enric Mateu, Jaime Gómez-Laguna, Irene Magdalena Rodríguez-Gómez
Frontiers in Veterinary Science, 2024 - Droplet digital PCR as alternative to microbiological culture for Mycobacterium tuberculosis complex detection in bovine lymph node tissue samples
José María Sánchez-Carvajal, Eduardo Vera-Salmoral, Belén Huerta, Ángela Galán-Relaño, Inés Ruedas-Torres, Fernanda Larenas-Muñoz, Inmaculada Luque, Librado Carrasco, Jaime Gómez-Laguna
Frontiers in Cellular and Infection Microbiology, 2024 - Proteomic analysis of granulomas from cattle and pigs naturally infected with Mycobacterium tuberculosis complex by MALDI imaging
Fernanda Larenas-Muñoz, José María Sánchez-Carvajal, Inés Ruedas-Torres, Carmen Álvarez-Delgado, Karola Fristiková, Francisco José Pallarés, Librado Carrasco, Eduardo Chicano-Gálvez, Irene Magdalena Rodríguez-Gómez, Jaime Gómez-Laguna
Frontiers in Immunology, 2024 - Impact of supplementation with dihydroxylated vitamin D3 on performance parameters and gut health in weaned Iberian piglets under indoor/outdoor conditions
Carmen Álvarez-Delgado, Inés Ruedas-Torres, José M. Sánchez-Carvajal, Feliciano Priego-Capote, Laura Castillo-Peinado, Ángela Galán-Relaño, Pedro J. Moreno, Esperanza Díaz-Bueno, Benito Lozano-Buenestado, Irene M. Rodríguez-Gómez, Librado Carrasco, Francisco J. Pallarés, Jaime Gómez-Laguna
Porcine Health Management, 2023 - Evaluation of the diagnostic accuracy of the serological test for paratuberculosis in cattle according to tuberculosis status
Francisco Jurado‐Martos, Fernando Cardoso‐Toset, Carmen Tarradas, Ángela Galán‐Relaño, José María Sánchez‐Carvajal, Inés Ruedas‐Torres, Eduardo Vera‐Salmoral, Fernanda Larenas‐Muñoz, Librado Carrasco, Jaime Gómez‐Laguna, Belén Huerta Lorenzo, Inmaculada Luque
Veterinary Record, 2023 - Optimization of real-time PCR protocols from lymph node bovine tissue for direct detection of Mycobacterium tuberculosis complex
Eduardo Vera-Salmoral, Jaime Gómez-Laguna, Ángela Galán-Relaño, Inés Ruedas-Torres, Librado Carrasco, Inmaculada Luque, Belén Huerta, José María Sánchez-Carvajal
Microbiology Spectrum, 2023 - Establishment of a Nipah Virus Disease Model in Hamsters, including a Comparison of Intranasal and Intraperitoneal Routes of Challenge
Stephen Findlay-Wilson, Lucy Flett, Francisco J. Salguero, Ines Ruedas-Torres, Susan Fotheringham, Linda Easterbrook, Victoria Graham, Stuart Dowall
Pathogens, 2023 - Diagnostic performance of faecal and tissue multiplex qPCR IS900/F57 for the detection of Mycobacterium avium subspecies paratuberculosis in cattle
Francisco Jurado-Martos, Fernando Cardoso-Toset, Carmen Tarradas, Ángela Galán-Relaño, José María Sánchez-Carvajal, Inés Ruedas-Torres, Eduardo Vera, Fernanda Larenas-Muñoz, Lidia Gómez-Gascón, Irene Magdalena Rodríguez-Gómez, Librado Carrasco, Jaime Gómez-Laguna, Belén Huerta Lorenzo, Inmaculada Luque
Research in Veterinary Science, 2023 - Comparative pathology of experimental pulmonary tuberculosis in animal models
Laura Hunter, Inés Ruedas-Torres, Irene Agulló-Ros, Emma Rayner, Francisco J. Salguero
Frontiers in Veterinary Science, 2023 - Characterisation and development of histopathological lesions in a guinea pig model of Mycobacterium tuberculosis infection
Fernanda Larenas-Muñoz, Inés Ruedas-Torres, Laura Hunter, Alison Bird, Irene Agulló-Ros, Rebecca Winsbury, Simon Clark, Emma Rayner, Francisco J. Salguero
Frontiers in Veterinary Science, 2023 - Detection and localization of atypical porcine pestivirus in the testicles of naturally infected, congenital tremor affected piglets
Lilla Dénes, Inés Ruedas‐Torres, Anna Szilasi, Gyula Balka
Transboundary and Emerging Diseases, 2022 - The Role of Histopathology as a Complementary Diagnostic Tool in the Monitoring of Bovine Tuberculosis
Fernanda Larenas-Muñoz, José M. Sánchez-Carvajal, Ángela Galán-Relaño, Inés Ruedas-Torres, Eduardo Vera-Salmoral, Lidia Gómez-Gascón, Alfonso Maldonado, Librado Carrasco, Carmen Tarradas, Inmaculada Luque, Irene M. Rodríguez-Gómez, Jaime Gómez-Laguna
Frontiers in Veterinary Science, 2022 - Time Series Transcriptomic Analysis of Bronchoalveolar Lavage Cells from Piglets Infected with Virulent or Low-Virulent Porcine Reproductive and Respiratory Syndrome Virus 1
J. M. Sánchez-Carvajal, I. M. Rodríguez-Gómez, I. Ruedas-Torres, S. Zaldívar-López, F. Larenas-Muñoz, R. Bautista-Moreno, J. J. Garrido, F. J. Pallarés, L. Carrasco, J. Gómez-Laguna
Journal of Virology, 2022 - PRRSV-1 induced lung lesion is associated with an imbalance between costimulatory and coinhibitory immune checkpoints
Inés Ruedas-Torres, José María Sánchez-Carvajal, Librado Carrasco, Francisco José Pallarés, Fernanda Larenas-Muñoz, Irene Magdalena Rodríguez-Gómez, Jaime Gómez-Laguna
Frontiers in Microbiology, 2022 - Activation of T-bet, FOXP3, and EOMES in Target Organs From Piglets Infected With the Virulent PRRSV-1 Lena Strain
Inés Ruedas-Torres, Jaime Gómez-Laguna, José María Sánchez-Carvajal, Fernanda Larenas-Muñoz, Inmaculada Barranco, Francisco José Pallarés, Librado Carrasco, Irene Magdalena Rodríguez-Gómez
Frontiers in Immunology, 2021 - Activation of regulated cell death in the lung of piglets infected with virulent PRRSV-1 Lena strain occurs earlier and mediated by cleaved Caspase-8
Jose María Sánchez-Carvajal, Inés Ruedas-Torres, Librado Carrasco, Francisco José Pallarés, Enric Mateu, Irene Magdalena Rodríguez-Gómez, Jaime Gómez-Laguna
Veterinary Research, 2021 - Prevalence of mycoplasma-like lung lesions in pigs from commercial farms from Spain and Portugal
FJ Pallarés, JA Añón, IM Rodríguez-Gómez, J Gómez-Laguna, R Fabré, JM Sánchez-Carvajal, I Ruedas-Torres, L Carrasco
Porcine Health Management, 2021 - The jigsaw of PRRSV virulence
I. Ruedas-Torres, I.M. Rodríguez-Gómez, J.M. Sánchez-Carvajal, F. Larenas-Muñoz, F.J. Pallarés, L. Carrasco, J. Gómez-Laguna
Veterinary Microbiology, 2021 - Up-Regulation of Immune Checkpoints in the Thymus of PRRSV-1-Infected Piglets in a Virulence-Dependent Fashion
Inés Ruedas-Torres, Irene M. Rodríguez-Gómez, José María Sánchez-Carvajal, Silvia Guil-Luna, Fernanda Larenas-Muñoz, Francisco J. Pallarés, Librado Carrasco, Jaime Gómez-Laguna
Frontiers in Immunology, 2021 - Melanosis Coli in Pigs Coincides With High Sulfate Content in Drinking Water
Irene M. Rodríguez-Gómez, Jaime Gómez-Laguna, Inés Ruedas-Torres, José M. Sánchez-Carvajal, Ángel V. Garrido-Medina, Gabino Roger-García, Librado Carrasco
Veterinary Pathology, 2021 - Real-Time PCR Validation for Mycobacterium tuberculosis Complex Detection Targeting IS6110 Directly From Bovine Lymph Nodes
José María Sánchez-Carvajal, Ángela Galán-Relaño, Inés Ruedas-Torres, Francisco Jurado-Martos, Fernanda Larenas-Muñoz, Eduardo Vera, Lidia Gómez-Gascón, Fernando Cardoso-Toset, Irene Magdalena Rodríguez-Gómez, Alfonso Maldonado, Librado Carrasco, Carmen Tarradas, Jaime Gómez-Laguna, Inmaculada Luque
Frontiers in Veterinary Science, 2021 - Activation of pro- and anti-inflammatory responses in lung tissue injury during the acute phase of PRRSV-1 infection with the virulent strain Lena
J.M. Sánchez-Carvajal, I.M. Rodríguez-Gómez, I. Ruedas-Torres, F. Larenas-Muñoz, I. Díaz, C. Revilla, E. Mateu, J. Domínguez, G. Martín-Valls, I. Barranco, F.J. Pallarés, L. Carrasco, J. Gómez-Laguna
Veterinary Microbiology, 2020 - Activation of the extrinsic apoptotic pathway in the thymus of piglets infected with PRRSV-1 strains of different virulence
Inés Ruedas-Torres, Irene Magdalena Rodríguez-Gómez, Jose María Sánchez-Carvajal, Francisco José Pallares, Inmaculada Barranco, Librado Carrasco, Jaime Gómez-Laguna
Veterinary Microbiology, 2020 - Impact of PRRSV strains of different in vivo virulence on the macrophage population of the thymus
Giulia Ogno, Irene M. Rodríguez-Gómez, Elena Canelli, Inés Ruedas-Torres, Belén Álvarez, Javier Domínguez, Paolo Borghetti, Paolo Martelli, Jaime Gómez-Laguna
Veterinary Microbiology, 2019
