SCREENING, DESIGN AND CHARACTERIZATION OF ALGAE-BASED TOPICAL DOSAGE FORM AS A REMEDY FOR DIGITAL AGEING FATIMA SANJERI DASANKOPPA, REVATI DHARAMPAL SAGARE, MEGHA N. SUREBAN, HASANPASHA N. SHOLAPUR, ARUNKUMAR GUNDAIAH RAMESH, VIJAYKUMAR MURUGESAN International Journal of Applied Pharmaceutics, 2025 Objective: To design and characterize algae-based topical dosage forms as a remedy for digital aging and to assess the compatibility and safety of the developed topical formulation through in-vitro studies. Methods: A Central Composite Design (CCD) was employed to systematically investigate the impact of stabilizer concentration, sonication amplitude, and time on the particle size and zeta potential of the formulations. Fourier Transform Infrared Spectroscopy (FTIR), Sun Protection Factor (SPF), and antioxidant activity of the drug were initially assessed. Different concentrations of phospholipid and ethanol were used to create the ethosomes. Size, surface charge, shape, and Entrapment Efficiency (EE) were used to develop and characterize the drug-containing ethosomes. After that, the improved ethosomes were added to create a topical gel formulation. It was tested for stability over three months by looking at its organoleptic, pH, viscosity, and Sun Protection Factor (SPF) activity. Results: The drug showed 78.94% efficacy in scavenging free radicals. The optimized ethosomes had a spherical form, particle size of 221.8 nm, surface charge is -28.21 mV, and a notable 99.36 % entrapment efficiency. The maximum Sun Protection Factor (SPF) activity was observed in the ethosomal gel EG2. Furthermore, the chosen topical gel held up well during the investigation. Conclusion: The objective of the study was to develop a stable and functionally effective gel by using suitable ingredients. The evaluation study of the developed gel showed good pH, antioxidant activity, and sun protection activity.
Phytochemicals identification, anti-microbial, anti-oxidant and anti-diabetic activities of Polygala sphenoptera Fresen DR HASANPASHA SHOLAPUR, Rajani Benchikeri, Dr. Fatima Sanjeri Dasankoppa, Kamaladevi T Kshtriya, Dr. Pramod Benchikeri Indian Journal of Natural Products and Resources, 2025 Polygala sphenoptera Fresen, belonging to the family Polygalaceae, is a plant traditionally used in folk medicine for various health benefits. However, its chemical composition and pharmacological properties have not been explored. This study was to prepare and optimise the ethanolic extract of P. sphenoptera, investigate its phytochemical composition, and evaluate its anti-microbial, in-vitro anti-oxidant and anti-diabetic activities. The ethanolic extract of the authenticated whole plant of P. sphenoptera was investigated for the presence of phytochemicals and evaluated for anti-microbial properties by determining the minimum inhibitory concentration and zone of inhibition. The anti-oxidant capacity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging assay. The anti-diabetic potential was assessed by measuring α-amylase and α-glucosidase inhibitory activities. Phytochemical investigations indicate the presence of carbohydrates, flavonoids, tannins, alkaloids, and phenolic compounds. The phenolic content of the extract was found to be 8.733 mg GAE/g. The extract demonstrated significant anti-microbial activity against both bacterial and fungal strains. In-vitro studies indicated that the plant extract possesses strong anti-oxidant and anti-diabetic properties. Further detailed research will help to understand its mechanisms and validate its therapeutic potential.
Design and Characterization of Microwave Irradiation Assisted Amorphous Solid Dispersion of Resveratrol Lakshmi Swapna Sai, Fatima Sanjeri Dasankoppa, Hasanpasha N Sholapur, Revati Dharampal Sagare Indian Journal of Pharmaceutical Education and Research, 2025 Background: One of the emerging solutions for facing the solubility as well as dissolution issues of poorly soluble drugs is formulation approach by dispersing drugs in hydrophilic carriers. Objectives: Present study aims in enhancing the solubility of resveratrol by amorphous solid dispersion technique. Materials and Methods: Solid dispersions were prepared by microwave irradiation where the irradiation time and the drug: carrier ratios were optimized using Design of Experiments by the effect of these critical parameters on solubility as a response variable. Results and Discussion: Solubility of the fabricated amorphous solid dispersions were analyzed and optimized at 1:5 drug: carrier ratio with an irradiation time of 5 min. Different characterization techniques like infrared spectroscopy, particle size, differential scanning calorimetry etc., were performed in order to study and prove the process of amorphization. The results of powder X-ray diffraction studies, scanning electron microscopic studies certainly highlighted the conversion of crystalline form of resveratrol into an amorphous form along with reduced particle size of 41 times in solid dispersion than that of pure resveratrol. Conclusion: With the present work, it can be concluded that microwave irradiation is an absolute approach in preparation of amorphous solid dispersions.
Design, development and evaluation of veterinary transdermal film of Azadirachta indica extract for treatment of mastitis Journal of Advanced Veterinary Research, 2024
Doped halloysite nanotubes as a nanocontainer for the fabrication of ciprofloxacin hydrochloride loaded 3D printed scaffolds Revati Dharampal Sagare, Fatima Sanjeri Dasankoppa, Hasanpasha N. Sholapur, N.R. Banapurmath, M.A. Umarfarooq Journal of Drug Delivery Science and Technology, 2023 Burn injuries are considered to be the most catastrophic form of skin injury , with a slight risk of mortality. This type of injury has a significant negative impact on both individuals and health care system. The hollow nano-tubular structures of doped halloysite nanotubes (DHNTs) facilitate in loading a wide variety of active molecules and make a potential nanocarrier for the delivery of drugs. Coincidentally, the high mechanical strength , good biocompatibility , and hemostasis properties of DHNTs offer a new platform for the fabrication of scaffolds to promote faster wound healing activity. Ciprofloxacin hydrochloride (Cip HCl) was chosen as the model drug to control the bacterial proliferation at the site of injury. Therefore, the present study was aimed to design a customized drug loaded nano-polymeric scaffolds by three dimensional (3D) printing techniques for tissue engineered applications in pharmaceutical sciences. Cip HCl loaded DHNTs coated poly vinyl alcohol pellets were extruded for the preparation of filaments by the hot melt extrusion process, and the prepared filaments were further processed for the fabrication of 3D printed scaffolds by fused deposit modelling (FDM) technique. The pellets were free-flowing with a coating efficiency of 60.23 – 82.65%. Scaffold 1 (S1) presented an excellent porous structure , while scaffold 2 (S2) revealed a slight porous structure with the porosity of 60%. The average pore diameter for both scaffolds ranged from 50.82 ± 23 to 93.06 ± 52 μm. S1 expressed a conventional release pattern of 73.35% ± 0.02 within 2 h of the time profile, S2 evidenced an inaugural burst release of 42.84% ± 0.05 at 2 h, followed by a sustained release of 85.54% ± 0.17 up to 12 h. Thus the FDM technique proves to be an ideal approach for the design of drug nanofiller coated polymeric 3D scaffolds for personalized drug delivery systems in the arena of tissue engineering and pharmaceutical sciences.
Procyanidin Dimer from the Stem Bark of Moringa oleifera (Lam.) Attenuates Insulin Resistance in Rats Hasanpasha N. Sholapur, Basanagouda M. Patil, Fatima Sanjeri Dasankoppa Journal of Biologically Active Products from Nature, 2023 AbstractAlcoholic extract and its ethyl acetate fraction of Moringa oleifera (Lam.) (MO), (Moringaceae) bark are experimentally claimed to possess insulin-sensitizing potentials. The present study aimed to isolate and characterize the phytochemical(s) responsible for insulin sensitization in dexamethasone-induced acute and chronic rat models for insulin resistance (IR). The reported ethyl acetate fraction from the alcoholic extract of the bark of MO was prepared and subjected to bioactivity-guided sub-fractionation and isolation of phytochemicals. A component responsible for improving insulin sensitivity in rat models for IR was isolated and reported for the first time from the bark of MO and its structure was characterized as a procyanidin dimer type of polyphenol by spectroscopic techniques.Keywords: DexamethasoneInsulin resistanceMoringa oleiferaOral glucose tolerance testProcyanidin
Halloysite nanotubes: Design, characterization and applications. A review REVATI DHARAMPAL SAGARE Farmacia, 2021 Halloysite nanotubes (HNTs) have several exciting potential applications in polymer nanocomposites. These are naturally sourced nanomaterials obtained from the mines as a natural deposit. The hollow tubular nanostructure with biocompatibility, environmental friendly and low-cost possessing makes halloysite as trendsetter in green nanotechnology. These are composed of double-layered, aluminosilicate minerals with an ultra-tiny hollow tubular structure in submicron range. The specific characteristics of HNTs lead to plentiful range of applications in environmental sciences, dye removal, anticorrosive coatings, in cosmetics, flame retardants, forensic science, etc. HNTs display remarkable thermal stability, faster adsorption rates, tuneable release rates, excellent drug encapsulation, biocompatibility, mechanical properties and ease of availability, therefore with numerous pharmaceutical applications. Nanomedical applications are gene delivery, tissue engineering, cancer and stem cells isolation and bio-imaging. This review is focused on the detailing HNTs for its structure features, functionalization methods, drug loading and their versatile applications.
Optimization of ultrasonic assisted extraction of antioxidants from moringa oleifera lam. leaves using response surface methodology Indian Drugs, 2019
Design, characterization and evaluation of mucoadhesive nasal in situ geling formulations of venlafaxine hydrochloride for brain targeting Indian Drugs, 2016
Fast dissolving tablets of promethazine: A novel oral formulation for the treatment of fractionated radiotherapy-induced nausea and emesis Indian Drugs, 2008
In vitro evaluation of Alstonia scholaris(L) R.Br. plant extracts for antioxidant property Indian Drugs, 2008
Production of asiaticoside from callus cultures of Centella asiatica (L) urban Plant Cell Biotechnology and Molecular Biology, 2007
RECENT SCHOLAR PUBLICATIONS
Surface Functionalization of Silicon Carbide with Chitosan and Hydroxyapatite for Bioactive Wound Healing and Tissue Regeneration MM Yadav, FS Dasankoppa, MA Somashekara, HN Sholapur, ... Journal of Drug Delivery Science and Technology, 108455 , 2026 2026
Design and Characterization of Microwave Irradiation Assisted Amorphous Solid Dispersion of Resveratrol LS Sai, FS Dasankoppa, HN Sholapur, RD Sagare INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH 59 (2), 574-584 , 2025 2025
SCREENING, DESIGN AND CHARACTERIZATION OF ALGAE-BASED TOPICAL DOSAGE FORM AS A REMEDY FOR DIGITAL AGEING FS DASANKOPPA, RD SAGARE, MN SUREBAN, HN SHOLAPUR, ... Int J App Pharm 17 (4), 166-177 , 2025 2025
Versatile and Emerging Applications of Halloysite Nanotubes: From Nanotechnology to Biomedicine and Environmental Solutions RD Sagare, FS Dasankoppa, HN Sholapur, M Mahesh, ... Biocomposite Nanomaterials and their Applications, 301-311 , 2024 2024 Citations: 2
Evaluation of Fractions of Artocarpus lakoocha R. on Doxorubicin Induced Myocardial Toxicity in Wistar Rats. S Nagmoti, SK Nimbal, HN Sholapur, S Hiremath Pharmacognosy Research 16 (4) , 2024 2024
A review on 4D printing technology for fabrication of intelligent, programmable and functional structure FS Dasankoppa, I Sidhaye, R Yashaswini, AV Karadagi, T Pujar, ... TWIST 19 (2), 421-431 , 2024 2024 Citations: 3
Design, development and evaluation of veterinary transdermal film of Azadirachta indica extract for treatment of mastitis SA Prabhu, FS Dasankoppa, HN Sholapur, RD Sagare Journal of Advanced Veterinary Research 14 (4), 602-609 , 2024 2024 Citations: 2
Procyanidin Dimer from the Stem Bark of Moringa oleifera (Lam.) Attenuates Insulin Resistance in Rats HN Sholapur, BM Patil, FS Dasankoppa Journal of Biologically Active Products from Nature 13 (5), 469-489 , 2023 2023 Citations: 3
Doped halloysite nanotubes as a nanocontainer for the fabrication of ciprofloxacin hydrochloride loaded 3D printed scaffolds RD Sagare, FS Dasankoppa, HN Sholapur, NR Banapurmath, ... Journal of Drug Delivery Science and Technology 86, 104637 , 2023 2023 Citations: 9
Design, optimization and characterization of γ-methacryloxypropyltrimethoxysilane-doped halloysite clay nanotubes using ultra-turrax homogenizer RD Sagare, FS Dasankoppa, HN Sholapur Journal of Pharmaceutical Innovation 18 (2), 719-734 , 2023 2023 Citations: 4
Neuro Protection of Calotropis Procera Leaf Extract in Neuropathy-Induced Rat Model AH Aayesha, N Mahurkar, M Alimoddin, MA Ahmed, HN Sholapur, ... Tuijin Jishu/Journal of Propulsion Technology 44 (3), 2023 , 2023 2023 Citations: 1
Quality by design approach for design, development and optimization of orally disintegrating tablets of Montelukast sodium H Sholapur, FS Dasankoppa, M Channabasavaraja, RD Sagare, Z Abbas, ... International Journal of Pharmaceutical Investigation 11 (3), 288-295 , 2021 2021 Citations: 5
Halloysite nanotubes: design, characterization and applications. A review RD Sagare, FS Dasankoppa, HN Sholapur, K Burga Farmacia 69 (2), 208-214 , 2021 2021 Citations: 17
Design, formulation, and evaluation of reservoir-type transdermal delivery of an antihypertensive drug. FS Dasankoppa, M Channavanavar, HN Sholapur, VG Jamakandi Drug Invention Today 14 (6) , 2020 2020
Application of Response Surface optimization methodology in designing ordispersible tablets of antdiabetic drug FS Dasankoppa, HN Sholapur, A Byahatti, Z Abbas, S Komal, K Subrata Journal of Young Pharmacists 12 (2), 173 , 2020 2020 Citations: 9
Design, formulation, and evaluation of in situ gelling ophthalmic drug delivery system comprising anionic and nonionic polymers FS Dasankoppa, P Solankiy, HN Sholapur, VG Jamakandi, VM Sajjanar, ... Indian Journal of Health Sciences and Biomedical Research kleu 10 (3), 323-330 , 2017 2017 Citations: 19
Effect of fractions of alcoholic extract of Moringa oleifera lam. Bark on dexamethasone induced insulin resistance in rats HN Sholapur, BM Patil Journal of Young Pharmacists 9 (3), 410 , 2017 2017 Citations: 4
Application of SeDeM ODT expert system in formulation development of orodispersible tablets of antihyperlipidemic agent FS Dasankoppa, VM Sajjanar, H Sholapur, NG Nanjundaswamy, ... Journal of Young Pharmacists 9 (2), 203-208 , 2017 2017 Citations: 6
Design, Optimization and Evaluation of Chewable Tablets of Clarithromycin using Ion Exchange Resins. FS Dasankoppa, S Komal, HN Sholapur, NG Nanjundaswamy, ... Indian Journal of Pharmaceutical Sciences 78 (6) , 2016 2016 Citations: 12
Article Details Design, characterization and evaluation of mucoadhesive nasal in situ gelling formulations of venlafaxine hydrochloride for brain targetting M Priyanka, D FS, HN Sholapur, NGN Swamy, V Sajjanar 2016
MOST CITED SCHOLAR PUBLICATIONS
Formulation and evaluation of a novel in situ gum based ophthalmic drug delivery system of linezolid SSP HIREMATH, FS Dasankoppa, A NADAF, VG JAMAKANDI, ... Scientia Pharmaceutica 76 (3), 515-532 , 2008 2008 Citations: 79
Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac FS Dasankoppa, M Ningangowdar, H Sholapur Journal of basic and clinical pharmacy 4 (1), 2 , 2012 2012 Citations: 48
Antidiabetic activity of Cassia fistula Linn. bark in alloxan induced diabetic rats SN Malpani, KP Manjunath, H Sholapur, RV Savadi, KS Akki, SS Darade Int J Pharm Sci Res 2, 382-385 , 2010 2010 Citations: 43
Pharmacognostic and phytochemical investigations on the bark of Moringa oleifera Lam HPN Sholapur, BM Patil Indian journal of natural products and resources 4 (1), 96-101 , 2013 2013 Citations: 40
Fast dissolving tablets of promethazine: A novel oral formulation for the treatment of fractionated radiotherapy-induced nausea and emesis JA Mulla, FS Dasankoppa, GJ Vilas, HP Sholapur INDIAN DRUGS-BOMBAY- 45 (4), 314 , 2008 2008 Citations: 30
Effect of Moringa oleifera bark extracts on dexamethasone-induced insulin resistance in rats HN Sholapur, BM Patil Drug research 63 (10), 527-531 , 2013 2013 Citations: 29
Design, formulation, and evaluation of in situ gelling ophthalmic drug delivery system comprising anionic and nonionic polymers FS Dasankoppa, P Solankiy, HN Sholapur, VG Jamakandi, VM Sajjanar, ... Indian Journal of Health Sciences and Biomedical Research kleu 10 (3), 323-330 , 2017 2017 Citations: 19
Halloysite nanotubes: design, characterization and applications. A review RD Sagare, FS Dasankoppa, HN Sholapur, K Burga Farmacia 69 (2), 208-214 , 2021 2021 Citations: 17
A review on hydrogels and its use in in situ ocular drug delivery NG Nanjundswami, FS Dasankoppa, HN Sholapur Indian J. Nov. Drug Deliv 1, 11-17 , 2009 2009 Citations: 16
Design, formulation and evaluation of carboxy methyl tamarind based in situ gelling ophthalmic drug delivery system of dorzolamide hydrochloride FS Dasankoppa, S Kujur, HPNA Sholapur, VG Jamakandi Indian Journal of Health Sciences and Biomedical Research kleu 9 (1), 56-66 , 2016 2016 Citations: 15
Design, Optimization and Evaluation of Chewable Tablets of Clarithromycin using Ion Exchange Resins. FS Dasankoppa, S Komal, HN Sholapur, NG Nanjundaswamy, ... Indian Journal of Pharmaceutical Sciences 78 (6) , 2016 2016 Citations: 12
Doped halloysite nanotubes as a nanocontainer for the fabrication of ciprofloxacin hydrochloride loaded 3D printed scaffolds RD Sagare, FS Dasankoppa, HN Sholapur, NR Banapurmath, ... Journal of Drug Delivery Science and Technology 86, 104637 , 2023 2023 Citations: 9
Application of Response Surface optimization methodology in designing ordispersible tablets of antdiabetic drug FS Dasankoppa, HN Sholapur, A Byahatti, Z Abbas, S Komal, K Subrata Journal of Young Pharmacists 12 (2), 173 , 2020 2020 Citations: 9
Formulation and characterization of colon specific drug delivery system of prednisolone FS Dasankoppa, S Patwa, H Sholapur, GR Arunkumar Saudi Journal for Health Sciences 1 (3), 143-150 , 2012 2012 Citations: 9
Phytochemical and pharmacognostic evaluation of Euphorbia hirta Linn. leaves. AM Kandalkar, KP Manjunath, HP Sholapur, AM Patel, SS Darade 2009 Citations: 9
Application of SeDeM ODT expert system in formulation development of orodispersible tablets of antihyperlipidemic agent FS Dasankoppa, VM Sajjanar, H Sholapur, NG Nanjundaswamy, ... Journal of Young Pharmacists 9 (2), 203-208 , 2017 2017 Citations: 6
Quality by design approach for design, development and optimization of orally disintegrating tablets of Montelukast sodium H Sholapur, FS Dasankoppa, M Channabasavaraja, RD Sagare, Z Abbas, ... International Journal of Pharmaceutical Investigation 11 (3), 288-295 , 2021 2021 Citations: 5
A comparative study of isolated flavonoid and different extracts of Caesalpinia pulcherrima (L) Sw. for in vitro immunomodulatory effects on human neutrophils SD Madagundi, MK Pawadshetter, HP Sholapur, P Habbu, SM Biradar 亚洲传统医药 7 (4), 159-167 , 2012 2012 Citations: 5
APPLICATION OF OPTIMIZATION TECHNIQUE IN SYNTHESIS AND CHARACTERIZATION OF SODIUM CARBOXY ETHYL GUAR. HN Sholapur, FS Dasankoppa, NG Nangundaswamy, GR Arunkumar J. Appl. Pharm 2 (4), 583-92 , 2012 2012 Citations: 5
Design, optimization and characterization of γ-methacryloxypropyltrimethoxysilane-doped halloysite clay nanotubes using ultra-turrax homogenizer RD Sagare, FS Dasankoppa, HN Sholapur Journal of Pharmaceutical Innovation 18 (2), 719-734 , 2023 2023 Citations: 4