A Review of Pre-clinical Data on the Pharmacotherapeutic Potential of Black Seeds (Nigella sativa) against Influenza Virus Infection Rajkapoor balasubramanian, Naina Mohamed Pakkir Maideen, Arun Shanmugam, Harikrishnan Narayanaswamy Current Traditional Medicine, 2026 Background and Objective: Influenza is a respiratory virus, and certain patients with some chronic conditions and other risk factors are vulnerable to severe infection requiring hospitalizations and further fatal complications. Few antiviral drugs are approved for the management of patients with influenza infection. Since N. sativa supplementation significantly reduces all-cause mortality, improves viral clearance, and diminishes viral loads in patients with SARS-CoV-2 infection and other viruses, including hepatitis C virus, our review focuses on the antiviral efficacy of black seeds (N. sativa) against influenza viruses. Methods: The databases, including Medline/PMC/PubMed, Scopus, Web of Science, Google Scholar, Science Direct, and reference lists, were searched to identify relevant publications using keywords, such as Nigella sativa, black seeds, black cumin seeds, kalonji, and influenza virus. This review included only English publications, while duplicates were excluded. Results: Supplementation with N. sativa improved clinical symptoms, enhanced cytokine gene expression, suppressed H9N2 virus pathogenesis, increased antibody titers against the H9N2 influenza virus, significantly reduced mortality, decreased virus shedding, promoted weight gain, boosted both cell-mediated and humoral immune responses, and facilitated early viral clearance in several preclinical studies involving H9N2-infected turkeys. Furthermore, a number of preclinical and clinical investigations showed that N. sativa has antiviral properties against other viruses. Furthermore, N. sativa has several pharmacotherapeutic potentials, including antiviral, immunomodulatory, antioxidant, and anti-inflammatory qualities that may be helpful in the treatment of influenza virus infection, according to multiple meta-analyses. Additionally, N. sativa's pharmacological properties, including its antihistaminic, bronchodilatory, antidiabetic, antiobesity, antihypertensive, antihyperlipidemic, and anticancer properties, may help to alleviate the signs, symptoms, and complications associated with influenza virus infection. Conclusion: To prevent further complications, patients at higher risk of developing complications from influenza virus infection could be managed with specific antivirals and black seeds (N. sativa) as adjunctive therapy in the early stages of infection. Future clinical studies would establish the effectiveness of black seeds (N. sativa) against influenza infection.
Artificial Intelligence for Biomarker Discovery and Clinical Trial Optimization S. Gejalakshmi, T. Sriramya, S. Salma Shaik, N. Harikrishnan, C. Aswin, K. Dharanitharan, Sivaram Ponnusamy Revolutionizing Drug Research and Personalized Medicine Through AI and Machine Learning, 2026 Biomarkers exist in various forms including molecular and genetic elements as well as imaging techniques and physiological and behavioral and digital markers which function as measurable indicators to track biological processes and disease states and therapeutic responses. These elements establish the basis for precision medicine through their capacity to detect diseases at their earliest stages and to classify risks and disease types and to track treatment results in real-time. Hence plays crucial role in AI field
Advances in molecularly imprinted polymers for targeting prostate cancer S Sridevi, S Ranjitha, Rukaiah Fatma Begum, Bhupendra G. Prajapati, S. Nirenjen, N Pavithra, N Harikrishnan, Ankul Singh S Revolutionizing Cancer Treatment the Power of Molecularly Imprinted Polymers for Precision Therapy, 2026
Real-World Barriers to Implementing Genotype-Guided Dosing in Clinical Practice Kiranmayi G.V.N., Harikrishnan N International Journal of Pharmaceutical Sciences and Nanotechnology, 2025 The routine application of pharmacogenomic insights in clinical settings marks a transformative shift toward individualized patient care and precision medicine. Genotype-guided dosing has demonstrated clinical benefits in optimizing the safety and efficacy of several medications, including warfarin, clopidogrel, and thiopurines 1,2. Despite the availability of well-established guidelines and robust scientific backing from entities such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG), the integration of pharmacogenomics into routine clinical practice remains limited. One major barrier is the lack of awareness and training among healthcare professionals. Studies show that many clinicians lack confidence in interpreting and applying pharmacogenomic data 3, which limits its utility at the point of care.
Influence of Anaemia and Gestational Diabetes Co-Related with Behavioural Changes for Quality of Life during Pregnancy: Holistic Integration of Clinical and Psychological Interventions for Better Pregnancy Outcomes Varaganti Sai Chitra Prathyusha, Fatima Grace Xavier, Narayanaswamy Harikrishnan, Evelyn Sharon Sukumaran, S. Prema International Journal of Advanced Science and Engineering, 2025 Anaemia and gestational diabetes mellitus (GDM) are prevalent comorbid conditions during pregnancy that significantly affect maternal health and fetal development.This study investigates the interrelationship between anaemia and GDM, their individual and synergistic influence on behavioural alterations, and the consequent implications for quality of life (QoL) among pregnant women.Conducted at a tertiary healthcare facility, this research integrates clinical assessments with psychological evaluations, employing standardized tools and biochemical markers to evaluate the impact of these conditions.The results reveal that women affected by both anaemia and GDM exhibit exacerbated mood disturbances, higher stress indices, and reduced physical vitality, which collectively diminish QoL.A holistic approach, combining timely clinical interventions and structured psychological counselling, demonstrated improved outcomes.These findings underscore the importance of interdisciplinary maternal care in mitigating pregnancy-related complications and enhancing overall wellbeing.
The complexity of basophobia and aging: covariates and consequences P. Premalatha, V. Krishnaraju, H. A. Shadia, M. Abuadas, F. Zainab, A. Rasha, E. L. Sampayan, M. A. Abeer, A. Hala, K. Prabahar, N. Harikrishnan, E. Vigneshwaran, V. Vinoth Prabhu, H. Alshareef, H. Manal European Review for Medical and Pharmacological Sciences, 2023
The overview: Recent studies on endometrial cancer Dhanalakshmi S., Harikrishnan N., Janani N., P. Shakthi Priya, Srinivasan M., Karthikeyan A., Anishkumar A., Harinathan R., Srinivasan N. Research Journal of Pharmacy and Technology, 2021
A perspective overview on hygrophila auriculata Dhanalakshmi S Dhanalakshmi, Harikrishnan N Harikrishnan, Srinivasan N Srinivasan, Pandian P Pandian, Tanisha BA Tanisha, M Tharun Kumar, Lokesh V Lokesh, Yuvashri N Yuvashri, Supriya S Supriya Pharmacognosy Journal, 2020
Method development and validation for assay of candesartancilexetil and hydrochlorothiazide in tablet dosage form by RP-HPLC International Journal of Research in Pharmaceutical Sciences, 2016
Synthesis and biological evaluation of pyrido(2, 3-d)pyrimidine-carboxylate derivatives Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2011
Protective effect of Phyllanthus polyphyllus on acetaminophen induced hepatotoxicity in rats Pakistan Journal of Pharmaceutical Sciences, 2008
Validated high performance thin layer chromatography method for simultaneous estimation of rofecoxib and tizanidine hydrochloride in pure and tablet dosage forms Asian Journal of Chemistry, 2007
Validated high performance liquid chromatography method for simultaneous estimation of paracetamol and aceclofenac in tablet dosage forms Asian Journal of Chemistry, 2007
Simultaneous estimation of aceclofenac and paracetamol by HPTLC in pure and pharmaceutical dosage form Asian Journal of Chemistry, 2007
Validated simultaneous estimation of simvastatin and ezetimibe by RP-HPLC in pure and pharmaceutical dosage form Asian Journal of Chemistry, 2007
Validated simultaneous estimation of ornidazole and cefixime by RP-HPLC in pure and pharmaceutical dosage form Asian Journal of Chemistry, 2007
Simultaneous estimation of levofloxacin hemihydrate and ornidazole in tablet dosage form by HPTLC Asian Journal of Chemistry, 2007
Simultaneous estimation and validation of simvastatin and ezetimibe by HPTLC in pure and pharmaceutical dosage forms Asian Journal of Chemistry, 2007
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Advances in molecularly imprinted polymers for targeting prostate cancer S Sridevi, S Ranjitha, RF Begum, BG Prajapati, S Nirenjen, N Pavithra, ... Revolutionizing Cancer Treatment, 65-93 , 2026 2026
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A Review of Pre-clinical Data on the Pharmacotherapeutic Potential of Black Seeds ( Nigella sativa ) against Influenza Virus Infection R Balasubramanian, NMP Maideen, A Shanmugam, N Harikrishnan Current Traditional Medicine 12 (1), E22150838352681 , 2026 2026
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Treatment modalities: Surgery and radiotherapy for eye melanoma S Sridevi, A Singh, A Monisha, N Harikrishnan, BG Prajapati Eye Melanoma Unveiled, 221-254 , 2026 2026
Real-World Barriers to Implementing Genotype-Guided Dosing in Clinical Practice GVN Kiranmayi, N Harikrishnan International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN … , 2025 2025
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Integrative approaches in Alzheimer’s disease: evaluating the potential of traditional, complementary, and integrative medicine (TCIM) R Sneha Sri, T Pavithra, T Vinciya, V Santhosh Kumar, N Harikrishnan, ... Frontiers in Pharmacology 16, 1561702 , 2025 2025 Citations: 2
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Hierarchical Meta-Reinforcement Learning for Uncertainty-Aware Resource Allocation in C-V2X Networks I Khan, D Somshekhar, N Harikrishnan, PU Neetha, D Pavithra 2025 International Conference on Machine Learning and Autonomous Systems … , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Multivariate statistical analysis of heavy metal concentration in soils of Yelagiri Hills, Tamilnadu, India–Spectroscopical approach A Chandrasekaran, R Ravisankar, N Harikrishnan, KK Satapathy, ... Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 137, 589-600 , 2015 2015 Citations: 298
Protective effect of Phyllanthus polyphyllus on acetaminophen induced hepatotoxicity in rats B Rajkapoor, Y Venugopal, J Anbu, N Harikrishnan, M Gobinath, ... Pak J Pharm Sci 21 (1), 57-62 , 2008 2008 Citations: 117
Antitumor and cytotoxic effects of Phyllanthus polyphyllus on Ehrlich ascites carcinoma and human cancer cell lines B Rajkapoor, M Sankari, M Sumithra, J Anbu, N Harikrishnan, M Gobinath, ... Bioscience, biotechnology, and biochemistry 71 (9), 2177-2183 , 2007 2007 Citations: 63
Effect of Bauhinia variegata on complete Freund's adjuvant induced arthritis in rats. B Rajkapoor, V Ravichandran, M Gobinath, J Anbu, N Harikrishnan, ... 2007 Citations: 42
Advances in chitosan based nanocarriers for targetted wound healing therapies: A review S Naveedunissa, R Meenalotchani, M Manisha, SA Singh, S Nirenjen, ... Carbohydrate Polymer Technologies and Applications 11, 100891 , 2025 2025 Citations: 34
A Review on Stability Indicating HPLC Method Development B Prathap, GH Srinivasa Rao B Prathap, GH Srinivasa Rao, G Devdass, Akalanka Dey, N Harikrishnan International Journal of Innovative Pharmaceutical Research. 3 (3), 229-237. , 2012 2012 Citations: 27
Validated simultaneous estimation of simvastatin and ezetimibe by RP-HPLC in pure and pharmaceutical dosage form K Shivshanker, N Sreekanth, N Harikrishnan, C Roosewelt, GS Rao, ... Asian Journal of Chemistry 19 (6), 4303 , 2007 2007 Citations: 23
Synthesis and biological evaluation of pyrido (2, 3-d) pyrimidine-carboxylate derivatives P Shanmugasundaram, N Harikrishnan, M Vijey Aanandini, ... Indian Journal of Chemistry-Part B OrganicIncluding Medicinal 50 (3), 284 , 2011 2011 Citations: 21
Exploring the potential of probiotics in Alzheimer's disease and gut dysbiosis S Sowmiya, LS Dhivya, N Harikrishnan, S Ankul Singh IBRO neuroscience reports 17, 441-455 , 2024 2024 Citations: 18
A perspective overview on Hygrophila auriculata S Dhanalakshmi, N Harikrishnan, N Srinivasan, P Pandian, BA Tanisha, ... Pharmacogn J 12 (6), 1748-52 , 2020 2020 Citations: 16
Formulation design and evaluation of extended-release tablets of oxybutynin for effective management of overactive bladder syndrome S Nandhakumar, G Sugreevudu, N Harikrishnan Research Journal of Pharmacy and Technology 14 (12), 6558-6564 , 2021 2021 Citations: 12
Simultaneous estimation of aceclofenac and paracetamol by HPTLC in pure and pharmaceutical dosage form N Harikrishnan, V Gunasekaran, A Sathishbabu, GS Rao, C Roosewelt Asian Journal of Chemistry 19 (5), 3918 , 2007 2007 Citations: 12
PHCOG MAG. Research Article Antimycobacterial, antiviral and cytotoxic studies of Indigofera aspalathoides Vahl B Rajkapoor, N Murugesh, S Kavimani, DR Krishna, V Ravichandran, ... Phcog Mag 3 (11), 163 , 2007 2007 Citations: 11
Recent advances in silver nanoparticles for enhanced wound healing with mechanisms, formulations, and clinical insights R Meenalotchani, S Nirenjen, M Manisha, BG Prajapati, E Arun, N Afreen, ... Journal of Drug Delivery Science and Technology, 107437 , 2025 2025 Citations: 9
A perspective view on nanosponge drug delivery system. S Dhanalakshmi, N Harikrishnan, BA Tanisha, G Pooja, L Yuvarani, ... Drug Invention Today 14 (3) , 2020 2020 Citations: 9
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Development and validation of UV spectrophotometric methods of Loratadine in bulk and pharmaceutical formulation N Harikrishnan, R Deepthi, V Manjusha, VP Satya, MJ Asha Jyothi, ... Asian J. Res. Chem 3 (2), 302-304 , 2010 2010 Citations: 8
Development and Validation of UV Spectrophotometric Method of Glibenclamide (Glyburide) in Bulk and Pharmaceutical Formulation N Harikrishnan, U Muralikrishna, B Shaik, V Bhavsar, VR Kumar Asian Journal of Research in Chemistry 3 (2), 316-318 , 2010 2010 Citations: 8
Simultaneous estimation of paracetamol, aceclofenac and chlorzoxazone in oral dosage form using spectrophotometric method N Harikrishnan, K Kalaivani, V Meher, V Gunasekaran, C Roosewelt Analytical Chemistry 5, 1-6 , 2007 2007 Citations: 7
Traditional, complementary, and integrative medicine in the management of ischemic stroke: a narrative review S Sowmiya, RF Begum, LS Dhivya, P Rajendran, N Harikrishnan, ... Frontiers in Pharmacology 16, 1561688 , 2025 2025 Citations: 6