LUONG THI NGOC HAN

@vanlanguni.edu.vn

LUONG THI NGOC HAN


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3

Scopus Publications

200

Scholar Citations

3

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Antioxidant and Blood Sugar-Stabilizing Activities of Extracts from Three Coloured Rice Varieties in Streptozotocin-Induced Diabetic Mice
    Han Luong, Dien To, Danh Vu
    Tropical Journal of Natural Product Research, 2022
    Purple brown rice (Oryza sativa L. indica), red rice (Oryza sativa L. Orysa), and black glutinous rice (Oryza sativa l. Glutinosa Tanaka) are three popular types of staple food, which are beneficial to human health. The present study was conducted to evaluate the antioxidant and hypoglycemic effects of three ethanol extracts from Vietnamese rice in streptozotocin-induced diabetic mice. Ethanol extracts were prepared from three varieties of rice, which included black glutinous rice (EOGT96), red rice (EOLO96), and purple-brown rice (EOLI96). Swiss albino male mice were divided into six groups: I (negative control), II (positive control), III (drug control group), IV (EOLT96), V (EOLI96), and VI (EOLO96). The antioxidant activity of the various extracts was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) and nitric oxide methods. The total phenolic content and the α-amylase inhibitory activity were also determined. The DPPH results revealed that the EOLI96 produced the highest antioxidant activity (IC50 = 19.38 ± 0.64 μg/mL), and the EOGT96 was only 3.7 times less potent at scavenging free radicals than the quercetin standard. In comparison to the other two extracts from rice varieties, the extract from EOGT96 also had the highest total polyphenol content. Blood sugar levels were much lower in the group of mice given the EOGT96 than in the control group, and they were similarly comparable to those of the animals administered glibenclamide. The findings of this study revealed that ethanol extract from black glutinous rice can reduce diabetes by lowering high blood sugar levels when used at the appropriate dosage.  
  • Anticancer activity of novel plant extracts and compounds from Adenosma bracteosum (Bonati) in human lung and liver cancer cells
    Ngoc-Hong Nguyen, Q. T. H. Ta, Q. Pham, T. Luong, V. Phung, T. Duong, V. Vo
    Molecules, 2020
    Cancer is the second leading cause of death globally, and despite the advances in drug development, it is still necessary to develop new plant-derived medicines. Compared with using conventional chemical drugs to decrease the side effects induced by chemotherapy, natural herbal medicines have many advantages. The present study aimed to discover the potential cytotoxicity of ethanol extract and its derived fractions (chloroform, ethyl acetate, butanol, and aqueous) of Adenosma bracteosum Bonati. (A. bracteosum) on human large cell lung carcinoma (NCI-H460) and hepatocellular carcinoma (HepG2). Among these fractions, the chloroform showed significant activity in the inhibition of proliferation of both cancerous cells because of the presence of bioactive compounds including xanthomicrol, 5,4’-dihydroxy-6,7,8,3’-tetramethoxyflavone, and ursolic acid which were clearly revealed by nuclear magnetic resonance spectroscopy (1H-NMR, 13C-NMR, Heteronuclear Multiple Bond Coherence, and Heteronuclear Single Quantum Coherence Spectroscopy) analyses. According to the radical scavenging capacity, the 5,4’-dihydroxy-6,7,8,3’-tetramethoxyflavone compound (AB2) exhibited the highest anticancer activity on both NCI-H460 and HepG2 with IC50 values of 4.57 ± 0.32 and 5.67 ± 0.09 µg/mL respectively, followed by the ursolic acid with the lower percent inhibition at 13.05 ± 0.55 and 10.00 ± 0.16 µg/mL, respectively (p < 0.05). Remarkably, the AB2 compound induced to significant increase in the production of reactive oxygen species accompanied by attenuation of mitochondrial membrane potential, thus inducing the activation of caspase-3 activity in both human lung and liver cancer cells. These results suggest that A. bracteosum is a promising source of useful natural products and AB2 offers opportunities to develop the novel anticancer drugs.
  • Potential antidiabetic activity of extracts and isolated compound from adenosma bracteosum (Bonati)
    Ngoc Hong Nguyen, Quang Thang Pham, Thi Ngoc Han Luong, Hoang Khai Le, Van Giau Vo
    Biomolecules, 2020
    Adenosma bracteosum Bonati. (A. bracteosum) has been used in traditional and modern medicine in Vietnam for curing hepatitis. In this study, ethanol and aqueous extracts of A. bracteosum were evaluated for their α-glucosidase inhibitory activities and anti-hyperglycemic effects on glucose loaded hyperglycemic and streptozotocin (STZ) induced diabetic mice. The α-glucosidase inhibition of the extracts was evaluated by colorimetric assays, and the anti-diabetic activity was tested on a STZ-induced diabetic mice model. The ethanol and aqueous extracts showed a significant α-glucosidase inhibitory activity, which was more effective than acarbose at the same concentration. In the STZ-induced diabetic mice, both extracts showed a strong anti-hyperglycemic activity, with the group receiving 50 mg/kg of ethanol extract and the group receiving 50 mg/kg of aqueous extract presenting 64.42% and 57.69% reductions, respectively, in the blood glucose levels when compared with the diabetic control group, on day 21 (p &gt; 0.05). Isoscutellarein-8-O-β-D-glucopyranoside (IG) was identified from the ethanol extract, which showed a strong inhibitory activity against α-glucosidase, with a ten times higher potency compared with the positive control acarbose. The anti-hyperglycemic effect of IG was effectively similar to the standard drug, glibenclamide, at the same dose of 10 mg/kg (p &gt; 0.05). These results indicated that A. bracteosum has a great antidiabetic potential.

RECENT SCHOLAR PUBLICATIONS

  • Antioxidant and Blood Sugar-Stabilizing Activities of Extracts from Three Coloured Rice Varieties in Streptozotocin-Induced Diabetic Mice
    Han Luong, Dien To, Danh Vu
    Tropical Journal of Natural Product Research 6 (7), 1103-1107 , 2022
    2022
    Citations: 2
  • Anticancer Activity of Novel Plant Extracts and Compounds from Adenosma bracteosum (Bonati) in Human Lung and Liver Cancer Cells
    NH Nguyen, QTH Ta, QT Pham, TNH Luong, VT Phung, TH Duong, ...
    Molecules 25 (12), 2912 , 2020
    2020
    Citations: 151
  • Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati)
    NH Nguyen, QT Pham, TNH Luong, HK Le, VG Vo
    Biomolecules 10 (2), 201 , 2020
    2020
    Citations: 44
  • ANTIOXIDANT ACTIVITY AND ANTI-HYPERGLYCEMIC EFFECT FROM Adenosma bracteosum Bonati.
    NN Hong, LTN Han, PQ Thang
    Journal of Biology/TẠp chí Sinh HỌc 40 , 2018
    2018
    Citations: 3

MOST CITED SCHOLAR PUBLICATIONS

  • Anticancer Activity of Novel Plant Extracts and Compounds from Adenosma bracteosum (Bonati) in Human Lung and Liver Cancer Cells
    NH Nguyen, QTH Ta, QT Pham, TNH Luong, VT Phung, TH Duong, ...
    Molecules 25 (12), 2912 , 2020
    2020
    Citations: 151
  • Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati)
    NH Nguyen, QT Pham, TNH Luong, HK Le, VG Vo
    Biomolecules 10 (2), 201 , 2020
    2020
    Citations: 44
  • ANTIOXIDANT ACTIVITY AND ANTI-HYPERGLYCEMIC EFFECT FROM Adenosma bracteosum Bonati.
    NN Hong, LTN Han, PQ Thang
    Journal of Biology/TẠp chí Sinh HỌc 40 , 2018
    2018
    Citations: 3
  • Antioxidant and Blood Sugar-Stabilizing Activities of Extracts from Three Coloured Rice Varieties in Streptozotocin-Induced Diabetic Mice
    Han Luong, Dien To, Danh Vu
    Tropical Journal of Natural Product Research 6 (7), 1103-1107 , 2022
    2022
    Citations: 2