HAMZA Assila

Verified @uit.ac.ma

Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco

HAMZA Assila


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https://researchid.co/hamzaassila

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Chemistry, General Chemistry
15

Scopus Publications

240

Scholar Citations

6

Scholar h-index

5

Scholar i10-index

Scopus Publications

  • Synthesis and characterization of two pyridazine N-aryl derivatives as corrosion inhibitors for carbon steel in 1 M HCl: Electrochemical, surface characterization and theoretical studies
    Hamza Assila, Malak Rehioui, Hamza El Hadki, Issam Ameziane El Hassani, Younes Zaoui, Fatima Lazrak, Hamid Erramli, M'Hammed Ansar
    Hybrid Advances, 2026
    The present study explores the corrosion inhibition efficiency of two newly synthesized pyridazine N-aryl acetamide derivatives PDZ-PS2 (2-(4-(2-chlorobenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl)-N-(2,6-dimethylphenyl)acetamide) and PDZ-PS3 (2-(4-(2-chlorobenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl)-N-phenylacetamide) on carbon steel in 1 M HCl solution. The structures of the two newly synthesized compounds were confirmed using NMR 13 C, 1 H, IR and mass spectrometry analyses. Electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP) analyses revealed a substantial increase in charge transfer resistance from 36.66 Ω·cm 2 (blank) to 458.90 Ω·cm 2 for PDZ-PS2 and 394.30 Ω·cm 2 for PDZ-PS3 at 10 -3 M, corresponding to inhibition efficiencies of 92.01% and 90.08%, respectively. The corrosion current density decreased markedly from 454.92 μA·cm -2 (blank) to 36.62 μA·cm -2 and 45.13 μA·cm -2 for PDZ-PS2 and PDZ-PS3 , confirming mixed-type inhibition behaviour. Adsorption followed the Langmuir isotherm, with high adsorption constants (K ads = 2.97 × 10 5 and 1.86 × 10 5 M -1 ) and negative free energies (ΔG° ads = −41.20 and −40.04 kJ·mol -1 ), indicating a spontaneous adsorption process involving mixed physical and chemical interactions, with chemisorption contribution. SEM and EDS analyses confirmed the formation of a compact protective layer on the steel surface. Monte Carlo simulations showed strong adsorption on the Fe(110) surface, with high binding energies of 530.39 kJ·mol -1 for PDZ-PS2 and 551.97 kJ·mol -1 for PDZ-PS3, confirming strong inhibitor–surface interactions. Overall, PDZ-PS2 exhibited slightly superior performance, demonstrating the strong corrosion protection potential of pyridazine-based acetamide derivatives in acidic environments.
  • Novel hydrazone-derived pyrazole-benzofuran compounds inhibit cancer cell growth by targeting MMPs, caspases, and PI3K/AKT/mTOR signaling pathway
    Issam Ameziane El Hassani, Ahmet Altay, Esma Yeniçeri, Youness Boukharsa, Hamza Assila, Abdullah Yahya Abdullah Alzahrani, Sana Ben Moussa, M'’hammed Ansar, Khalid Karrouchi
    Bioorganic Chemistry, 2026
  • Pharmacological Valorization of Saffron Stigmas (Crocus sativus L.): Green Ultrasonic Processing and Molecular Docking Analysis of Antioxidant Bioactives
    Abdessamad Benlabchir, Mouhcine Fadil, Kawtar Fikri-Benbrahim, Hamza Assila, Otman El-Guourrami, Asma Halmoune, Elbatoul Hanoune, Abdelmounaim Laabar, Soufiane Drioua, Zineb Ouaritini
    Tropical Journal of Natural Product Research, 2026
    Saffron (Crocus sativus L.) is a valuable source of bioactive molecules renowned for their health benefits. However, efficient extraction of phenolic compounds using conventional techniques remains challenging. This study aimed to optimize ultrasound-assisted extraction (UAE) conditions for saffron stigmas using a Box–Behnken design. UAE parameters were optimized to maximize total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity [Ferric reducing antioxidant power (FRAP)] under different conditions. Three parameters were investigated: extraction time, solvent-to-material ratio, and solvent (ethanol/water) concentration. TPC, TFC, and FRAP were determined using standard spectrophotometric methods. In addition, in silico pharmacokinetic properties of selected bioactive compounds from saffron were analysed using the ADMELab platform. Molecular docking of the selected compounds was performed against two antioxidant-related targets: human tyrosinase (PDB ID: 5M8O) and human peroxiredoxin 5 (PRDX5) (PDB ID: 1H2D) using Aotodock toolkit. The best extraction conditions were identified as 15 min, 30 mL/g, 80% ethanol for TPC (32.15 mg GAE/g DW) and TFC (93.55 mg QE/g DW), and 45 min, 30 mL/g, 80% ethanol for antioxidant activity (EC₅₀ = 0.37 mg/mL), with desirability values > 99.9%. Regression models demonstrated high predictive reliability (R² = 0.96-0.97), confirming the higher efficiency of UAE compared with maceration and decoction. Furthermore, in silico studies revealed favourable pharmacokinetic properties for crocetin, picrocrocine, crocin-4, and safranal, and molecular docking highlighted a strong binding affinity of crocin-1 with antioxidant-related targets. Overall, UAE proved to be a robust and predictive strategy for optimizing saffron phenolic extraction, reinforcing its antioxidant and bioactive potential.
  • Novel hybrid pyridazinone-arylacetamide: Synthesis, crystal structure, toxicity, antidiabetic activity, oral starch tolerance test (OSTT), absorption distribution metabolism excretion toxicity (ADMET) and docking studies
    Hamza Assila, Salma Mortada, Walid Guerrab, Issam Ameziane El Hassani, Younes Zaoui, Joel Mague, Moulay Abbes Faouzi, Ahlam I. Al-Sulami, Youssef Ramli, M’Hammed Ansar
    Journal of Molecular Structure, 2026
  • (E)-N'-(4-methoxybenzylidene)-2-((5-phenyl-1H-pyrazol-3-yl)oxy)acetohydrazide as potential antidiabetic agent: Synthesis, X-ray, Hirshfeld surface, biological evaluation and computational studies
    Issam Ameziane El Hassani, Chin-Hung Lai, Salma Mortada, Arulraj Ramalingam, Hamza Assila, Suhana Arshad, Hatem A. Abuelizz, My El Abbes Faouzi, Khalid Karrouchi, M’hammed Ansar
    Journal of Molecular Structure, 2026
  • Novel Pyridazinone-1,3,4-oxadiazole Hybrids as Antioxidant and Antidiabetic Agents: Synthesis, Biological Evaluation, ADMET, and Molecular Docking Studies
    Younes Zaoui, Salma Mortada, Hamza Assila, Abdellah Messoussi, Walid Guerrab, My El abbes Faouzi, Youssef Ramli, Khalid Karrouchi, M'hammed Ansar
    Chemistryselect, 2025
    Pyridazin‐3(2H)‐one and 1,3,4‐oxadiazole have emerged as promising lead candidates for inhibiting glucose‐metabolizing enzymes, such as α‐glucosidase and α‐amylase. Furthermore, several investigations have demonstrated their strong antioxidant activities. In the present work, we report the synthesis of novel molecules hybridizing a pyridazin‐3(2H)‐one ring and a 1,3,4‐oxadiazole ring. The compounds were screened for their antioxidant activity. In DPPH and ABTS assays, compound O7 exhibited the most potent antioxidant activity, with IC 50 values of 21.32 ± 0.30 µmol/mL and 11.52 ± 0.10 µM, respectively, higher than that of sodium ascorbate. In the FRAP assay, compounds O3 (70.51 ± 3.12 µM) and O7 (61.53 ± 0.67 µM) showed superior iron‐reducing activity. As regards their antidiabetic activity, compounds O3 and O7 showed potent α‐amylase inhibitory activity with IC 50 values of 99.93 ± 1.71 µM and 93.12 ± 3.10 µM, respectively. Compound O3 also possessed the highest α‐glucosidase Inhibition activity, with an IC 50 of 22.06 ± 0.24 µM, far higher than acarbose. The molecular docking study also supported that the O3 compound shows maximum binding interaction on α‐amylase and α∖glucosidase. The binding of O3 to these enzymes is through various hydrophobic and hydrogen bonds, responsible for its good stability and justifying its strong inhibitory action.
  • Design, synthesis, stereochemical characterization, in vitro α-glucosidase, and α-amylase inhibition and in silico studies of novel pyrazole-hydrazide hydrazones
    Issam Ameziane El Hassani, Salma Mortada, Njabulo J. Gumede, Hamza Assila, Ali Alsalme, Afaf Oulmidi, My El Abbes Faouzi, Khalid Karrouchi, M’hammed Ansar
    Medicinal Chemistry Research, 2025
  • GC–MS Characterization and Bioactivity Study of Eucalyptus globulus Labill. (Myrtaceae) Essential Oils and Their Fractions: Antibacterial and Antioxidant Properties and Molecular Docking Modeling
    Abdessamad Ait benlabchir, Kawtar Fikri-Benbrahim, Amina Moutawalli, Mohammed M. Alanazi, Asma Halmoune, Fatima Zahra Benkhouili, Asmaa Oubihi, Atul Kabra, Elbatoul Hanoune, Hamza Assila, Zineb Benziane Ouaritini
    Pharmaceuticals, 2024
    Background/Objectives: Eucalyptus globulus is a medicinal plant extensively used by the Moroccan population for treating a range of illnesses, especially respiratory conditions. Methods: This study aimed to assess the antioxidant and antibacterial properties of E. globulus essential oil and its individual fractions (F1, F2, and F3). Antioxidant activity was evaluated through iron-reducing power, 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. Antibacterial activity was tested using disk diffusion and dilution methods, supported by molecular docking studies. Furthermore, GC–MS analysis was conducted on the essential oil and its individual fractions. Results: GC–MS analysis identified the major compounds in the essential oil and its fractions as eucalyptol (62.32–42.60%), globulol (5.9–26.24%), o-cymene (6.89–24.35%), cryptone (7.10–15.95%), terpinen-4-ol (2.43–15.24%), and α-pinene (2.46–7.89%). Fraction F3 displayed the highest antioxidant activity in DPPH (IC50 = 3.329 ± 0.054 mg/mL) and ABTS assays (IC50 = 3.721 ± 0.027 mg/mL), while fraction F2 was most effective in the FRAP assay (IC50 = 1.054 ± 0.008 mg/mL). The essential oil and its fractions also showed antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, Enterobacter cloacae, Escherichia coli, and Acinetobacter baumannii. Molecular docking further corroborated these findings, supporting both antioxidant and antibacterial activities. Conclusions: The present findings demonstrate the antioxidant and antimicrobial properties of Eucalyptus globulus essential oil and its fractions, underscoring the need for further research to confirm their medicinal potential and explore pharmaceutical applications.
  • Synthesis, crystal structure and Hirshfeld surface analysis of 2-{4-[(2-chlorophenyl)methyl]-3-methyl-6-oxopyridazin-1-yl}-N-phenylacetamide
    Hamza Assila, Younes Zaoui, Camille Kalonji Mubengayi, Walid Guerrab, Abdulsalam Alsubari, Joel T. Mague, Youssef Ramli, Mhammed Ansar
    Acta Crystallographica Section E Crystallographic Communications, 2024
    In the title molecule, C20H18ClN3O2, the 2-chlorophenyl group is disordered to a small extent [occupancies 0.875 (2)/0.125 (2)]. The phenylacetamide moiety is nearly planar due to a weak, intramolecular C—H...O hydrogen bond. In the crystal, N—H...O hydrogen bonds and π-stacking interactions between pyridazine and phenyl rings form helical chains of molecules in the b-axis direction, which are linked by C—H...O hydrogen bonds and C—H...π(ring) interactions. A Hirshfeld surface analysis was performed, which showed that H...H, C...H/H...C and O...H/H...O interactions to dominate the intermolecular contacts in the crystal.
  • Pyridazine derivative as potent antihyperglycemic agent: Synthesis, crystal structure, α-amylase and α-glucosidase inhibition and computational studies
    Hamza Assila, Silvia A. Brandán, Salma Mortada, Younes Zaoui, Abdullah Yahya Abdullah Alzahrani, Suhana Arshad, Youssef Ramli, My El Abbes Faouzi, Khalid Karrouchi, M'hammed Ansar
    Journal of Molecular Structure, 2024
  • Novel Pyrazole-Based Benzofuran Derivatives as Anticancer Agents: Synthesis, Biological Evaluation, and Molecular Docking Investigations
    Issam Ameziane El Hassani, Ahmet Altay, Khalid Karrouchi, Esma Yeniçeri, Burçin Türkmenoğlu, Hamza Assila, Youness Boukharssa, Youssef Ramli, M'hammed Ansar
    Chemistry and Biodiversity, 2023
  • 2-[4-(2-Chlorobenzyl)-3-methyl-6-oxo-1,6-dihydropyridazin-1-yl]-N-(4-fluorophenyl)- acetamide
    Hamza Assila, Issam Ameziane El Hassani, Abderrazzak El Moutaouakil Ala Allah, Abdulsalam Alsubari, Joel T Mague, Youssef Ramli, MHammed Ansar
    Iucrdata, 2023
  • Recent Advances in the Synthesis of Pyrazole Derivatives: A Review
    Issam Ameziane El Hassani, Khouloud Rouzi, Hamza Assila, Khalid Karrouchi, M’hammed Ansar
    Reactions, 2023
  • Ethyl 2-[4-(4-methoxybenzyl)-3-methyl-6-oxopyridazin-1-yl]acetate
    Younes Zaoui, Hamza Assila, Joel T Mague, Abdulsalam Alsubari, Jamal Taoufik, Youssef Ramli, Mhammed Ansar
    Iucrdata, 2022
  • Crystal structure and Hirshfeld surface analysis of (E)-3-benzylidene-4-oxopentanoic acid
    Hamza Assila, Younes Zaoui, Issam Ameziane El Hassani, Samira El Ghammarti, Joel T. Mague, Jamal Taoufik, Youssef Ramli, Mhammed Ansar
    Acta Crystallographica Section E Crystallographic Communications, 2022

RECENT SCHOLAR PUBLICATIONS

  • Synthesis and Characterization of Two Pyridazine N-Aryl Derivatives as Corrosion Inhibitors for Carbon Steel in 1 M HCl: Electrochemical, Surface Characterization and …
    H Assila, M Rehioui, H El Hadki, IA El Hassani, Y Zaoui, F Lazrak, ...
    Hybrid Advances, 100638 , 2026
    2026.0
    Citations: 1
  • Pharmacological Valorization of Saffron Stigmas (Crocus sativus L.): Green Ultrasonic Processing and Molecular Docking Analysis of Antioxidant Bioactives.
    AA Benlabchir, M Fadil, K Fikri-Benbrahim, H Assila, O El-Guourrami, ...
    Tropical Journal of Natural Product Research 10 (2), 7169 , 2026
    2026.0
  • Novel hydrazone-derived pyrazole-benzofuran compounds inhibit cancer cell growth by targeting MMPs, caspases, and PI3K/AKT/mTOR signaling pathway
    IA El Hassani, A Altay, E Yeniçeri, Y Boukharsa, H Assila, AYA Alzahrani, ...
    Bioorganic Chemistry, 109568 , 2026
    2026.0
    Citations: 1
  • Tropical Journal of Natural Product Research
    A Ait Benlabchir, M Fadil, K Fikri-Benbrahim, H Assila, O El-Guourrami, ...
    Extraction 1, 0 , 2026
    2026.0
  • Novel Pyridazinone‐1, 3, 4‐oxadiazole Hybrids as Antioxidant and Antidiabetic Agents: Synthesis, Biological Evaluation, ADMET, and Molecular Docking Studies
    Y Zaoui, S Mortada, H Assila, A Messoussi, W Guerrab, ...
    ChemistrySelect 10 (41), e02946 , 2025
    2025.0
  • Novel hybrid pyridazinone-arylacetamide: Synthesis, crystal structure, toxicity, antidiabetic activity, oral starch tolerance test (OSTT), absorption distribution metabolism …
    H Assila, S Mortada, W Guerrab, IA El Hassani, Y Zaoui, J Mague, ...
    Journal of Molecular Structure, 144480 , 2025
    2025.0
    Citations: 3
  • (E)-N'-(4-methoxybenzylidene)-2-((5-phenyl-1H-pyrazol-3-yl) oxy) acetohydrazide as potential antidiabetic agent: Synthesis, X-ray, Hirshfeld surface, biological evaluation and …
    IA El Hassani, CH Lai, S Mortada, A Ramalingam, H Assila, S Arshad, ...
    Journal of Molecular Structure, 143934 , 2025
    2025.0
    Citations: 5
  • Design, synthesis, stereochemical characterization, in vitro α-glucosidase, and α-amylase inhibition and in silico studies of novel pyrazole-hydrazide hydrazones
    I Ameziane El Hassani, S Mortada, NJ Gumede, H Assila, A Alsalme, ...
    Medicinal Chemistry Research 34 (1), 252-271 , 2025
    2025.0
    Citations: 21
  • GC–MS Characterization and Bioactivity Study of Eucalyptus globulus Labill. (Myrtaceae) Essential Oils and Their Fractions: Antibacterial and Antioxidant …
    A Ait Benlabchir, K Fikri-Benbrahim, A Moutawalli, MM Alanazi, ...
    Pharmaceuticals 17 (11), 1552 , 2024
    2024.0
    Citations: 20
  • Synthesis, crystal structure and Hirshfeld surface analysis of 2-{4-[(2-chlorophenyl) methyl]-3-methyl-6-oxopyridazin-1-yl}-N-phenylacetamide
    H Assila, Y Zaoui, C Kalonji Mubengayi, W Guerrab, A Alsubari, JT Mague, ...
    Structure Reports 80 (11), 1221-1225 , 2024
    2024.0
    Citations: 1
  • Pyridazine derivative as potent antihyperglycemic agent: Synthesis, crystal structure, α-amylase and α-glucosidase inhibition and computational studies
    H Assila, SA Brandan, S Mortada, Y Zaoui, AYA Alzahrani, S Arshad, ...
    Journal of Molecular Structure 1308, 138145 , 2024
    2024.0
    Citations: 16
  • Novel Pyrazole‐Based Benzofuran Derivatives as Anticancer Agents: Synthesis, Biological Evaluation, and Molecular Docking Investigations
    I Ameziane El Hassani, A Altay, K Karrouchi, E Yeniçeri, B Türkmenoğlu, ...
    Chemistry & Biodiversity 20 (11), e202301145 , 2023
    2023.0
    Citations: 18
  • 2-[4-(2-Chlorobenzyl)-3-methyl-6-oxo-1, 6-dihydropyridazin-1-yl]-N-(4-fluorophenyl) acetamide
    H Assila, I Ameziane El Hassani, A El Moutaouakil Ala Allah, A Alsubari, ...
    IUCrData 8 (10), x230901 , 2023
    2023.0
    Citations: 2
  • Recent advances in the synthesis of pyrazole derivatives: a review
    I Ameziane El Hassani, K Rouzi, H Assila, K Karrouchi, M Ansar
    Reactions 4 (3), 478-504 , 2023
    2023.0
    Citations: 142
  • Ethyl 2-[4-(4-methoxybenzyl)-3-methyl-6-oxopyridazin-1-yl] acetate
    Y Zaoui, H Assila, JT Mague, A Alsubari, J Taoufik, Y Ramli, M Ansar
    IUCrData 7 (6), x220582 , 2022
    2022.0
    Citations: 6
  • Crystal structure and Hirshfeld surface analysis of (E)-3-benzylidene-4-oxopentanoic acid
    H Assila, Y Zaoui, I Ameziane El Hassani, S El Ghammarti, JT Mague, ...
    Structure Reports 78 (6), 563-567 , 2022
    2022.0
    Citations: 4
  • DFT-Guided Design, Synthesis, Molecular Docking, ADMET profiling, and in vitro assays of new pyridazinone derivatives as antioxidant and α-amylase inhibitors
    H EL BECHNA, N Oufkir, H Assila, M Hajji, S El Bassami, O Rebouzi, ...
    Khairo el baria and Al-Ghulikah, Hanan and Ouabane, Hajar and Benzeid … , 0
  • Synthesis of a new 1, 2, 4-triazole derivative and a preliminary investigation of its corrosion inhibitory effect against E24 carbon steel corrosion in 1M HCl
    F Lazrak, M Rehioui, S Lahmidi, S Abbout, N Oufkir, IA El Hassani, ...
    on Research and Innovation (ICRI’23), 124 , 0

MOST CITED SCHOLAR PUBLICATIONS

  • Recent advances in the synthesis of pyrazole derivatives: a review
    I Ameziane El Hassani, K Rouzi, H Assila, K Karrouchi, M Ansar
    Reactions 4 (3), 478-504 , 2023
    2023.0
    Citations: 142
  • Design, synthesis, stereochemical characterization, in vitro α-glucosidase, and α-amylase inhibition and in silico studies of novel pyrazole-hydrazide hydrazones
    I Ameziane El Hassani, S Mortada, NJ Gumede, H Assila, A Alsalme, ...
    Medicinal Chemistry Research 34 (1), 252-271 , 2025
    2025.0
    Citations: 21
  • GC–MS Characterization and Bioactivity Study of Eucalyptus globulus Labill. (Myrtaceae) Essential Oils and Their Fractions: Antibacterial and Antioxidant …
    A Ait Benlabchir, K Fikri-Benbrahim, A Moutawalli, MM Alanazi, ...
    Pharmaceuticals 17 (11), 1552 , 2024
    2024.0
    Citations: 20
  • Novel Pyrazole‐Based Benzofuran Derivatives as Anticancer Agents: Synthesis, Biological Evaluation, and Molecular Docking Investigations
    I Ameziane El Hassani, A Altay, K Karrouchi, E Yeniçeri, B Türkmenoğlu, ...
    Chemistry & Biodiversity 20 (11), e202301145 , 2023
    2023.0
    Citations: 18
  • Pyridazine derivative as potent antihyperglycemic agent: Synthesis, crystal structure, α-amylase and α-glucosidase inhibition and computational studies
    H Assila, SA Brandan, S Mortada, Y Zaoui, AYA Alzahrani, S Arshad, ...
    Journal of Molecular Structure 1308, 138145 , 2024
    2024.0
    Citations: 16
  • Ethyl 2-[4-(4-methoxybenzyl)-3-methyl-6-oxopyridazin-1-yl] acetate
    Y Zaoui, H Assila, JT Mague, A Alsubari, J Taoufik, Y Ramli, M Ansar
    IUCrData 7 (6), x220582 , 2022
    2022.0
    Citations: 6
  • (E)-N'-(4-methoxybenzylidene)-2-((5-phenyl-1H-pyrazol-3-yl) oxy) acetohydrazide as potential antidiabetic agent: Synthesis, X-ray, Hirshfeld surface, biological evaluation and …
    IA El Hassani, CH Lai, S Mortada, A Ramalingam, H Assila, S Arshad, ...
    Journal of Molecular Structure, 143934 , 2025
    2025.0
    Citations: 5
  • Crystal structure and Hirshfeld surface analysis of (E)-3-benzylidene-4-oxopentanoic acid
    H Assila, Y Zaoui, I Ameziane El Hassani, S El Ghammarti, JT Mague, ...
    Structure Reports 78 (6), 563-567 , 2022
    2022.0
    Citations: 4
  • Novel hybrid pyridazinone-arylacetamide: Synthesis, crystal structure, toxicity, antidiabetic activity, oral starch tolerance test (OSTT), absorption distribution metabolism …
    H Assila, S Mortada, W Guerrab, IA El Hassani, Y Zaoui, J Mague, ...
    Journal of Molecular Structure, 144480 , 2025
    2025.0
    Citations: 3
  • 2-[4-(2-Chlorobenzyl)-3-methyl-6-oxo-1, 6-dihydropyridazin-1-yl]-N-(4-fluorophenyl) acetamide
    H Assila, I Ameziane El Hassani, A El Moutaouakil Ala Allah, A Alsubari, ...
    IUCrData 8 (10), x230901 , 2023
    2023.0
    Citations: 2
  • Synthesis and Characterization of Two Pyridazine N-Aryl Derivatives as Corrosion Inhibitors for Carbon Steel in 1 M HCl: Electrochemical, Surface Characterization and …
    H Assila, M Rehioui, H El Hadki, IA El Hassani, Y Zaoui, F Lazrak, ...
    Hybrid Advances, 100638 , 2026
    2026.0
    Citations: 1
  • Novel hydrazone-derived pyrazole-benzofuran compounds inhibit cancer cell growth by targeting MMPs, caspases, and PI3K/AKT/mTOR signaling pathway
    IA El Hassani, A Altay, E Yeniçeri, Y Boukharsa, H Assila, AYA Alzahrani, ...
    Bioorganic Chemistry, 109568 , 2026
    2026.0
    Citations: 1
  • Synthesis, crystal structure and Hirshfeld surface analysis of 2-{4-[(2-chlorophenyl) methyl]-3-methyl-6-oxopyridazin-1-yl}-N-phenylacetamide
    H Assila, Y Zaoui, C Kalonji Mubengayi, W Guerrab, A Alsubari, JT Mague, ...
    Structure Reports 80 (11), 1221-1225 , 2024
    2024.0
    Citations: 1
  • Pharmacological Valorization of Saffron Stigmas (Crocus sativus L.): Green Ultrasonic Processing and Molecular Docking Analysis of Antioxidant Bioactives.
    AA Benlabchir, M Fadil, K Fikri-Benbrahim, H Assila, O El-Guourrami, ...
    Tropical Journal of Natural Product Research 10 (2), 7169 , 2026
    2026.0
  • Tropical Journal of Natural Product Research
    A Ait Benlabchir, M Fadil, K Fikri-Benbrahim, H Assila, O El-Guourrami, ...
    Extraction 1, 0 , 2026
    2026.0
  • Novel Pyridazinone‐1, 3, 4‐oxadiazole Hybrids as Antioxidant and Antidiabetic Agents: Synthesis, Biological Evaluation, ADMET, and Molecular Docking Studies
    Y Zaoui, S Mortada, H Assila, A Messoussi, W Guerrab, ...
    ChemistrySelect 10 (41), e02946 , 2025
    2025.0
  • DFT-Guided Design, Synthesis, Molecular Docking, ADMET profiling, and in vitro assays of new pyridazinone derivatives as antioxidant and α-amylase inhibitors
    H EL BECHNA, N Oufkir, H Assila, M Hajji, S El Bassami, O Rebouzi, ...
    Khairo el baria and Al-Ghulikah, Hanan and Ouabane, Hajar and Benzeid … , 0
  • Synthesis of a new 1, 2, 4-triazole derivative and a preliminary investigation of its corrosion inhibitory effect against E24 carbon steel corrosion in 1M HCl
    F Lazrak, M Rehioui, S Lahmidi, S Abbout, N Oufkir, IA El Hassani, ...
    on Research and Innovation (ICRI’23), 124 , 0