Possui Graduação em Medicina pela Universidade Federal do Maranhão (2002), Mestrado em Patologia pela Universidade de São Paulo (2007) e Doutorado em Patologia pela Universidade de São Paulo (2009). Atualmente é responsável técnico do Setor de Patologia do Hospital Universitário da Universidade Federal do Maranhão (HU-UFMA) e Membro da Comissão Gestora do Banco de Tumores do HU-UFMA. É coordenador do Laboratório de Imunofluorescência e Microscopia Eletrônica (LIME-HUUMA) e Docente permanente do Programa de Pós-graduação em Saúde do Adulto (PPGSAD/UFMA). Líder do Grupo de Pesquisa em Patologia Molecular - GEPAM (HU-UFMA), cadastrado no diretório dos Grupos de Pesquisa do CNPQ e Bolsista de Produtividade da Fundação de Amparo à Pesquisa e Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA). Tem experiência na área de Medicina, com ênfase em Anatomia Patológica, atuando principalmente nos seguintes temas: Patologia renal, COVID-19, Autópsia, HPV, Câncer de pênis e Patologia cirú
RESEARCH, TEACHING, or OTHER INTERESTS
Pathology and Forensic Medicine, Nephrology, Urology, Urology
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Scopus Publications
Scopus Publications
Intraperitoneal Local Anesthetic Instillation for Post-Operative Pain Control After Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Breno Dias L. Ribeiro, Italo C. Martins, Maria Júlia de Sena Lopes, Luis Eduardo Rodrigues Pereira, Maciel da Silva Cassiano, et al. World Journal of Surgery, 2026 Background Postoperative pain after bariatric surgery is a significant clinical challenge, with approximately 61.4% of patients reporting persistent pain. Intraperitoneal local anesthetic instillation (IPLA) has been proposed as a strategy to reduce pain and opioid‐related adverse effects. However, as its effectiveness in bariatric procedures remains controversial, this meta‐analysis was conducted to clarify the role of IPLA in this setting. Methods This systematic review and meta‐analysis was conducted following PRISMA guidelines and was prospectively registered in PROSPERO. We performed a comprehensive search in Pubmed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science for randomized controlled trials (RCTs) IPLA instillation with a control group in patients undergoing bariatric surgery. The primary outcomes were postoperative pain intensity, need for rescue analgesia, and supplementary opioid consumption. Secondary outcomes included postoperative nausea and vomiting (PONV), nausea, vomiting, and shoulder pain. Data were synthesized using a random‐effects model to calculate Risk Ratios (RR) for binary outcomes and Standardized Mean Differences (SMD) and Mean Differences (MD) for continuous outcomes. The methodological quality of the trials was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool. Results The analysis included 13 randomized controlled trials with a total of 1205 participants, of whom 624 were in the intraperitoneal local anesthetic (IPLA) group and 581 were in the control group. The pooled results showed that IPLA significantly reduced postoperative pain intensity (SMD: −0.96, 95% CI −1.72 to −0.20; p = 0.01) and the need for rescue analgesia (RR: 0.52, 95% CI 0.31–0.89). However, there was no significant difference in postoperative opioid consumption (SMD: −0.56, 95% CI −1.13 to 0.01; p = 0.05). Additionally, no significant effects were found for the incidence of postoperative nausea and vomiting (PONV) or shoulder pain. High heterogeneity was noted in most of the analyses. Conclusion IPLA reduces postoperative pain in bariatric surgery but does not decrease opioid consumption or adverse events. A suggested reduction in rescue analgesia was not robust. Due to high heterogeneity, the findings' clinical applicability is limited, highlighting the need for standardized trials. Trail Registration PROSPERO protocol CRD420251085223—July 2025
Brief results of heterotopic xenotransplantation of meningioma into the peritoneum of Wistar rats: an experimental study L.F.M. da Silva Junior, M.J.S. dos Santos, A.O. do Carmo, R.O.L. Silva, M.A.G. Campos, et al. Brazilian Journal of Medical and Biological Research, 2026 Meningiomas are the most common primary intracranial tumors, and xenotransplantation models help to study their behavior and test therapies. This research developed a model implanting WHO grade I meningothelial meningioma into the peritoneum of immunosuppressed rats, comparing it to subcutaneous implantation. The primary objective was to analyze tumor growth and progression, focusing on the role of the microenvironment. Peritoneal implants (1.87±0.25 cm) grew significantly larger than subcutaneous implants (0.86±0.14 cm) (P<0.0001). An inverse correlation was found between weight variation and the difference in implant sizes, indicating that weight loss in animals was associated with larger implant growth. Animals that lost weight had significantly larger implants compared to those that gained weight. Implantation site and the animal's weight variation can significantly impact the growth of meningothelial meningioma fragments, with peritoneal implants showing greater growth and weight loss correlating with larger tumors.
Collapsing Glomerulopathy in Brazil: A Nationwide Descriptive Study Marcos Adriano Garcia Campos, Precil Diego Miranda de Meneses Neves, Érico Murilo Monteiro Cutrim, Andressa Monteiro Sodré, João Victor Carvalho, et al. Nephrology, 2025 Aim Collapsing glomerulopathy (CG) is a glomerular disease that progresses rapidly to renal replacement therapy (RRT). Brazil is a conducive site for studies on CG because of its significant burden of infectious diseases and a high frequency of APOL1 risk variants. We described the clinical characteristics, histopathological findings, and outcomes of CG patients. Methods This retrospective survey analysed data from 2014 to 2022 from 18 centres of nephrology in all Brazilian regions. CG was diagnosed by kidney biopsy (KB), and the data were collected from medical records: initial symptoms, treatment, evolution to RRT. Results A total of 330 patients were included. Most patients were men (61.2%) and of Brown/Black ethnicity (72.7%). The mean age was 32 years. The most common symptoms were loss of renal function (44.2%), nephrotic proteinuria (80.07%), and hematuria (52.31%). KB revealed mild tubular atrophy and interstitial fibrosis (53.3%), moderate‐to‐severe interstitial inflammation (35.9%), and acute tubular necrosis (19.0%). On immunofluorescence, IgM (75.5%) and C3 (81.2%) were found to be most frequently deposited. Secondary etiologies were identified in 94 patients: HIV (13.8%), autoimmune disease (15.9%), and APOL1 high‐risk genotype (48.6%, 35/72). The mean follow‐up period was 13 months. Nephrotic proteinuria persisted in 78.8% of patients, and 30.5% progressed to RRT within 3 months after diagnosis. Conclusion CG affects young patients, leading to RRT in one‐third of cases in approximately 3 months. This multicentre study sets the baselines for risk factors and outcomes in the largest population studies on CG.
Adenovirus Interstitial Nephritis After Kidney Transplant: Case Series and Literature Review Ézio Arthur Monteiro Cutrim, Marcos Adriano Garcia Campos, Eleanor Strand, Érico Murilo Monteiro Cutrim, Andressa Monteiro Sodré, et al. Kidney360, 2025 Key Points Adenovirus Interstitial Nephritis has nonspecific clinical manifestation, and kidney biopsy played an essential role in establishing its condition.The most specific histopathological finding is interstitial nephritis with a granulomatous pattern.The evolution is favorable in most cases, and there was recovery of kidney function a few months after the diagnostic. Background Post-kidney transplant (KT) adenovirus (AdV) nephritis is a condition with potential for acute allograft dysfunction, and evidence on its management is scarce. Methods This study is an original case series based on kidney biopsy (KB) of seven patients obtained at a health center specialized in kidney pathology from 2009 to 2023. We also performed a nonsystematic literature review on patients described in the literature. Results KB was used to define the diagnosis of all patients. The average time to diagnosis after transplantation was 32.9 months. The most prevalent symptoms were fever, macroscopic hematuria, and dysuria. The GFR reduced on average four times in relation to the baseline GFR. The main findings of KB were acute tubular necrosis (100%), necrotizing granulomatous interstitial nephritis (100%), and viral inclusions (100%). The therapies used were human Igs, antivirals, and reduction of immunosuppression. The clinical course was favorable in six of the seven patients. Our literature review found 44 patients with AdV interstitial nephritis, and the outcome was favorable in most reported patients. Conclusions AdV interstitial nephritis is a rare condition with important implications for KT recipients. KB plays a very important role in confirmation. This study fills gaps in the current literature on AdV interstitial nephritis and contributes to the understanding of this potential complication in the follow-up of KT recipients.
Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study Fernando Sabino Marques Monteiro, Antonio Machado Alencar Junior, Karine Martins da Trindade, Taiane Francieli Rebelatto, Fernando C Maluf, et al. Oncologist, 2025 Background Penile squamous cell carcinoma (PSCC) is a rare malignancy. However, in developing countries the incidence rate is higher. The understanding of molecular alterations is essential for evaluating possible targets for more effective systemic therapies. Methods We retrospectively collected clinical data of metastatic PSCC (mPSCC) patients who had received at least one prior systemic treatment from 3 Brazilian hospitals. Tumor samples were evaluated using the next-generation sequencing (NGS) Foundation One DX and immunohistochemistry (IHC). The objective was to identify and describe somatic genomic alterations known to be functional or pathogenic and their association with survival outcomes. Results Twenty-three patients were identified, 22 and 18 patients had tumor samples analyzed by IHC and NGS, respectively. PD-L1 expression (CPS ≥ 1%) was positive in 14 patients (63.6%). Regarding the genomic alterations, 16 patients (88.9%) had some clinically relevant genomic alterations. TP53, TERT, CDKN2A, PIK3CA, NOTCH1, and CDKN2B loss were identified in 66.7%, 50%, 50%, 33.3%, 27.8%, and 22.2% of the patients, respectively. No MSI or TMB high (≥10 mutations/MB) cases were identified. NOTCH1 mutation was identified only in HPV-negative patients and it was associated with worse OS (yes: 5.5 vs no: 12.8 months, P = .049) and progression-free survival (yes: 5.5 vs no: 11.7 months, P = .032). Conclusion This study demonstrated that molecular alterations in mPSCC from developing countries are similar to those from developed countries. Predictive biomarkers for immunotherapy response such as TMB high or MSI were not identified. Specific gene mutations may identify patients with worse prognoses and open new avenues for therapeutic development.
Acute myocardial infarction in a young patient with Chikungunya: a case report João Gabriel Costa, Pedro Manuel Barros de Sousa, Marina Medeiros Orsi, Marcos Adriano Garcia Campos, Romullo José Costa Ataides, et al. Revista do Instituto De Medicina Tropical De Sao Paulo, 2025 Chikungunya virus (CHIKV) is globally distributed and transmitted by Aedes mosquitoes, with a mortality rate of 0.8/1,000 cases. The heart is the second most affected organ, with the osteoarticular system being the first. Cardiac involvement ranges from acute symptoms like myocarditis and exacerbation of pre-existing conditions to long-term complications such as dilated cardiomyopathy. While a direct association between CHIKV and acute myocardial infarction (AMI) is rare, systemic inflammation associated with chronic post-Chikungunya arthritis may destabilize atherosclerotic plaques, increasing AMI risk. This case report describes an AMI with non-obstructive coronary arteries in a previously healthy 24-year-old male infected with CHIKV. He presented low back pain, nausea, sweating, dyspnea, progressive leg edema, fever, and polyarticular pain in the knees and ankles. He was in critical condition upon admission, with decreased consciousness and hemodynamic instability, requiring transfer to the intensive care unit. He died 24 h later. Autopsy revealed a significantly enlarged heart, no visible atherosclerosis in the coronary arteries, and an extensive infarction in the interventricular septum. Histology showed coagulation necrosis, alveolar hemorrhage, and hepatic congestion. RT-PCR for CHIKV was detected in the lungs and heart tissues, while tests for other infectious diseases were negative. Studies highlight the role of mitochondrial antiviral signaling protein (MAVS) in protecting cardiac tissue from chronic CHIKV-related effects. Impaired MAVS signaling may enable continued viral replication, leading to myocarditis and vascular inflammation. Co-infection with dengue fever further increases the risk of cardiac complications. Postmortem analysis is essential to confirm CHIKV-related cardiac deaths and improve understanding and management of severe manifestations.
Chordoma Spontaneous Regression After COVID-19 Luis Fernando Moura da Silva Junior, Gyl Eanes Barros Silva, Marcos Adriano Garcia Campos, Antonio Augusto Lima Teixeira Júnior, Ramon Moura Santos, et al. Viruses, 2025
Non-Coding RNA in Penile Cancer Jaqueline Diniz Pinho, Gyl Eanes Barros Silva, Antonio Augusto Lima Teixeira-Júnior, Thalita Moura Silva Rocha, Lecildo Lira Batista, et al. Frontiers in Oncology, 2022
Primary Leiomyosarcoma of the Glans Raimundo Nonato Gois da Costa Junior, Antonio Augusto Lima Teixeira Júnior, Thalita Moura Silva Rocha, Thaís Bastos Moraes Sobrinho, Liseana de Oliveira Barbosa, et al. Frontiers in Oncology, 2022
Non-lupus full-house nephropathy: A case series Márcia de Oliveira Silva, Patrick Vanttinny Vieira de Oliveira, Pedro Henrique Cavalcante Vale, Rinadja de Melo Cunha, Joyce Santos Lages, et al. Brazilian Journal of Nephrology, 2021
P16INK4a expression in patients with penile cancer Vicenilma de Andrade Martins, Jaqueline Diniz Pinho, Antonio Augusto Lima Teixeira Júnior, Leudivan Ribeiro Nogueira, Fábio França Silva, et al. Plos One, 2018
Rhinosporidiosis: The largest case series in Brazil Francílio Araújo Almeida, Laisson de Moura Feitoza, Jaqueline Diniz Pinho, George Castro Figueira de Mello, Joyce Santos Lages, et al. Revista Da Sociedade Brasileira De Medicina Tropical, 2016
A case series of diffuse crescentic IgA nephropathy: An omitted entity in the Oxford classification International Journal of Clinical and Experimental Pathology, 2016
A novel case report of sickle cell disease-associated immunoglobulin a nephropathy: The diagnostic value of erythrocyte dysmorphism evaluation International Journal of Clinical and Experimental Medicine, 2014
Necrotizing arteritis in a human immunodeficiency virus-infected patient with lupus-like glomerulonephritis International Journal of Clinical and Experimental Pathology, 2014
Cyclin D1 expression in prostate carcinoma R.A. Pereira, R.C. Ravinal, R.S. Costa, M.S. Lima, S. Tucci, et al. Brazilian Journal of Medical and Biological Research, 2014
Corticotherapy response in primary IgA nephropathy. Natália Novaretti, Gyl Eanes Barros Silva, Roberto Silva Costa, Miguel Moysés Neto, Osvaldo Merege Vieira Neto, et al. Jornal Brasileiro De Nefrologia Orgao Oficial De Sociedades Brasileira E Latino Americana De Nefrologia, 2013
Renal diseases in the elderly underwent to percutaneous biopsy of native kidneys. Jornal Brasileiro De Nefrologia Orgao Oficial De Sociedades Brasileira E Latino Americana De Nefrologia, 2010