Phytochemical Screening and Bioactivity of Vigna radiata (Mung Bean) During In Vitro Gastrointestinal Digestion Aritrika Sen, Ankrita Thapa, Gouhar Jahan Ashraf, Partha Pratim Maiti, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Ranabir Sahu Journal of Food Process Engineering, 2026 The mung bean ( Vigna radiata L.) is considered to be one of the most frequently used legumes that are rich in phytochemicals, including phenolics with beneficial effects for human health. There is little information on the effect of in vitro gastrointestinal digestion (GID) on the phytochemical content and their biological activities. Differences in phytochemical content were observed across digestion stages (mouth, stomach, intestine, basolateral, and colon). GC–MS analysis further revealed structural modifications of phytochemicals during digestion. Phenolic fractions of V. radiata showed higher total phenolic content (25.39 ± 1.71 mg GAE/g) and total flavonoid content (14.68 ± 1.09 mg QRE/g) in the bound fraction than in the free one. Comparatively higher TPC, TFC, and TCC values were obtained for the mouth phase than for other digestion phases, suggesting rapid release of soluble compounds at the initial stage of digestion. Changes in in vitro antioxidant activity, protein stabilization, and α‐amylase inhibition were observed across various digestion phases, indicating a strong dependence of bioactivity on phytochemical transformations. The values of bioaccessibility ranged from 26.93% ± 1.07% to 93.41% ± 1.24%, illustrating variation in compound availability across phases. In general, the results demonstrate the effect of GID on the composition, bioavailability, and physiological properties of V. radiata compounds in an in vitro system.
Next-generation composite vesicular systems: an in-depth review of proniosomes in advanced drug delivery Jagabandhu Bag, Subhankar Mukhopadhyay, Gouranga Nandi, Hein Min Tun Drug Delivery, 2026 Proniosomes represent an advanced composite vesicular platform that integrates non-ionic surfactants, lipids, and biodegradable carriers to significantly improve drug solubility, stability, and transmembrane delivery. These dry powdery formulations are transformed into multiscale niosomes upon contact with a hydrated medium to achieve controlled release and enhanced drug permeability. This seminal review delineates the transformative potential of proniosomal systems in treating various diseases, detailing diverse routes of administration, formulation techniques, mechanisms of action, as well as their advantages and limitations. Proniosomes address major issues such as systemic toxicity, poor solubility, and erratic absorption while maintaining green chemistry principles owing to their biodegradable constituents. By critically analyzing the potential for industrial translation, this review highlights the knowledge gap on clinical studies, scalability, and regulatory issues. The translation potential has even been further enhanced by recent developments in bioconjugation and nanotechnology, such as ligand-anchored proniosomes that enable active targeting. The topic's relevance is evident, as proniosomes complement next-generation biotechnology tools, such as mRNA delivery, while offering a sustainable alternative to liposomes. By compiling the most recent data, this review strives to catalyze innovation in novel drug delivery, making it essential for researchers and pharmaceutical developers.
Preface Role of Nutraceuticals in Degenerative Diseases Part 2, 2026
Uses of tailor-made plant starches in drug delivery Md Saquib Hasnain, Mohd Usman Mohd Siddique, Manoj M. Gadewar, Mohammed Tahir Ansari, Mohd Neyaz Ahsan, Gouranga Nandi, Amit Kumar Nayak Tailor Made Polysaccharides in Drug Delivery, 2022
Alginate-based systems for protein and peptide delivery Paramita Paul, Gouranga Nandi, Mohammed A. Abosheasha, Hriday Bera Tailor Made and Functionalized Biopolymer Systems for Drug Delivery and Biomedical Applications, 2021
