Nutrition and Dietetics, Public Health, Environmental and Occupational Health
23
Scopus Publications
Scopus Publications
Organization and Integration of Care in the HIV–Non-Communicable Disease Syndemic: A Rapid Scoping Review Ketyllem Tayanne da Silva Costa, Maria Francisca da Conceição Maciel Targino, Pedro Ivo Torquato Ludugerio, Gidyenne Christine Bandeira Silva de Medeiros, Grasiela Piuvezam, et al. International Journal of Environmental Research and Public Health, 2026 Advances in antiretroviral therapy have transformed infection with HIV into a manageable chronic disease, increasing the survival of people living with HIV, who are also undergoing a demographic aging process marked by the emergence of non-communicable chronic diseases. This study aims to map and analyze how the scientific literature addresses the organization and integration of care in the HIV-NCD syndemic, identifying implications for nursing and for health systems. This is a Rapid Scoping Review, using the databases PubMed, Scopus, CINAHL, and LILACS. Data synthesis was conducted using Microsoft Excel. The research was structured using the PCC framework: Population—people living with HIV (≥18 years); Concept—organization and integration of care in the HIV-NCD syndemic, including care models, care coordination, service integration, and the role of nursing; and Context—health services and systems. Twenty-three studies were included, most of which used qualitative methodology, were conducted in sub-Saharan Africa, and had predominantly female samples. This study demonstrated that the organization of care in the HIV-NCD syndemic remains predominantly characterized by fragmented models, which are insufficient to address the complexity of multimorbidity. Integrated care models emerge as a promising strategy; however, their effects remain limited in settings marked by health inequalities.
Quality of patient safety indicators in intensive care units: Protocol for a systematic review Isac Davidson Santiago Fernandes Pimenta, Ádala Nayana de Sousa Mata, Gidyenne Christine Bandeira Silva de Medeiros, Daniel Guillén-Martínez, Manuel Pardo Ríos, et al. Plos One, 2026 Patient safety is an important issue in intensive care units. Patient safety indicators are often incorporated without undergoing the proper process of development and validation, which leads to problems with construct validity, measurement reliability, feasibility, and comparability across institutions and countries. This study reports a protocol for a systematic review that aims to identify and assess the validity of patient safety indicators used in the intensive care unit context. This protocol was previously registered in PROSPERO (CRD42024617125). We will search for original studies in the following databases: PubMed (Medline), Scopus, EMBASE (Elsevier), CINHAL (EBSCO), Web of Science, Cochrane Database and Google Scholar for grey literature. We will include methodological or observational studies that report the construction and/or validation of patient safety indicators. Two reviewers will independently screen and assess the studies, and disagreements will be resolved by a third reviewer. We will assess the quality of the studies using the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) checklist. To assess indicator validity, we will use the Appraisal of Indicators through Research and Evaluation (AIRE) instrument. We will classify the indicators according to Donabedian attributes of structure, process and outcomes, as well as the contexts of intensive care, such as pediatric, neonatal or cardiac units, for example. We will also perform descriptive analysis of each category assessed. We expect that our review will contribute to providing a valid set of indicators and help to identify gaps regarding patient safety dimensions that need to be assessed by new indicators.
Following the Food Consumption Footprints of Adults and the Elderly Around the World: A Systematic Review Camila V S de Souza, Larissa M A J Seabra, Maria Hatjiathanassiadou, Diogo Vale, Gidyenne C B S de Medeiros, et al. Nutrition Reviews, 2026 Context The search for sustainable food production and consumption is increasing globally. Sustainable diets capable of promoting human and environmental health are widely promoted by governmental and nongovernmental organizations to contribute to the achievement of food and nutritional security and the health of people and the planet. Objective The published literature on the environmental footprint of food consumption by adults and the elderly around the world was reviewed. Data Sources A systematic search was carried out of the Web of Science, PubMed, LILACS, MedLine, and Science Direct databases. Review studies, studies with theoretical diets, scenario studies without presenting the current diet, and projections were excluded. Data Extraction The inclusion criteria were population-based studies that quantified the environmental footprints of food consumption by adults and the elderly. The main characteristics of the study and the risk of bias were extracted independently by 2 researchers. Data Analysis A total of 3243 articles were obtained, of which 30 were included for synthesis according to the established eligibility criteria. The primary environmental footprints of consumption by adults and the elderly were carbon, water, land use, and energy. Adult men had higher environmental footprints than the other groups. There is no standardization in the data sources used to measure footprints, and the boundary of the food system considered in the analysis was generally from primary production to retail. Studies that considered the stages of food preparation and food waste in households obtained higher footprint values but presented more significant challenges in their realization. Conclusions The findings of this research demonstrate the challenges and possibilities in the field of research into the environmental footprint of food consumption and the relevance of this portrait in the quest to promote healthy and sustainable food systems.
Relationship between blood concentration of zinc and selenium and prognosis in post-acute myocardial infarction: A protocol for systematic review and meta-analysis Ana Francisca Teixeira Gomes, Lisandra Mikaely Barboza da Silva, Raissa Beatriz Silvestre Carneiro, Raquel Costa Silva Dantas-Komatsu, Gidyenne Christine Bandeira Silva de Medeiros, et al. Plos One, 2025 Acute Myocardial Infarction (AMI) is characterized by the presence of injury caused by an ischemic event, which leads to various complications, including Heart Failure (HF), the most severe functional stage of the heart, reducing both quality of life and life expectancy. Among the factors involved in this process, essential trace elements such as zinc and selenium stand out, as they are related to cardiovascular health and may help mitigate the harmful changes resulting from AMI. The objective of this protocol is to detail the development of two systematic reviews to gather scientific evidence on the relationship between zinc and selenium and the prognosis following AMI. This protocol was developed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guideline and registered in the International Prospective Register of Systematic Reviews (PROSPERO) under the code CRD42024574424. Search strategies will be conducted using a combination of controlled and uncontrolled terms combined with Boolean operators, and the following databases will be used: MEDLINE/PubMed, EMBASE, LILACS, Scopus, Web of Science, Trip database, and World Wide Science. Cohort studies that evaluated zinc and selenium in the prognosis after AMI will be included. Two trained researchers will independently select articles, extract data, and assess the risk of bias and the quality of the evidence. A narrative synthesis will be performed, and the main findings will be presented in tables. If possible, a meta-analysis will also be conducted.
Severity of COVID-19 in hospitalized pediatric patients with obesity: A systematic review Thainá O. Morais, Gidyenne C. B. Silva de Medeiros, Kleyton S. de Medeiros, Thayanne G. de Medeiros Mendes, Lucia Leite‐Lais, et al. Journal of Pediatric Gastroenterology and Nutrition, 2025 This review is intended to evaluate the severity of Coronavirus Disease 2019 (COVID‐19) in hospitalized pediatric patients with obesity. The increased risk of hospitalization in pediatric patients with obesity highlights the need for a thorough investigation into the impact of COVID‐19 in this vulnerable population, given the significant public health challenges obesity presents in this age group. The review followed the PRISMA (Preferred Reporting Items for Systematic Review and Meta‐Analysis Protocols) guidelines. A systematic search was conducted in the PubMed/MEDLINE (Medical Literature Analysis and Retrieval System Online), LILACS (scientific health information from Latin America and the Caribbean countries), Web of Science, Embase, and Scopus databases for relevant articles published between December 2019 and November 2021. Observational studies (cross‐sectional and cohort) involving pediatric patients with obesity who tested positive for COVID‐19, were hospitalized, and had outcomes related to disease severity parameters such as intensive care unit (ICU) admission, length of ICU stay, and mechanical ventilation) were included. The quality of evidence from the included studies was assessed using the Newcastle‒Ottawa Scale. Extracted data included the author, year, country, study design, aim, population, outcomes/severity, and primary results. Eight studies were included in the review. A narrative synthesis was conducted to qualitatively summarize the findings, highlighting that obesity is a potential aggravating factor in the clinical presentation of COVID‐19 among hospitalized pediatric patients. The findings revealed a positive association between the pediatric population with obesity and COVID‐19 severity, particularly among adolescents, who were at greater risk of developing severe illness. This association was also evident in higher rates of ICU admission and increased use of mechanical ventilation.
Evidence-Based Nutritional Recommendations for Maintaining or Restoring Nutritional Status in Patients with Amyotrophic Lateral Sclerosis: A Systematic Review Mariana Dantas de Carvalho Vilar, Karla Monica Dantas Coutinho, Sancha Helena de Lima Vale, Mario Emilio Teixeira Dourado Junior, Gidyenne Christine Bandeira Silva de Medeiros, et al. Nutrients, 2025 Background/Objectives: This study is a systematic review of guidelines that aims to synthesize evidence-based recommendations to support appropriate nutritional management for patients with amyotrophic lateral sclerosis (ALS). Methods: PubMed/MEDLINE, Embase, Scopus, SciELO, Web of Science, LILACS, ScienceDirect, and Google Scholar were searched for records published up to July 2024. Clinical practice guidelines addressing any aspect of nutritional intervention in ALS were included. No language or country of publication restrictions were applied. Data extraction was performed by two independent reviewers. The methodological quality of the reports was assessed using the AGREE II instrument. Discrepancies were resolved by consensus. Results: The findings and main recommendations were summarized narratively. A total of 837 records were identified, and 11 were included in this review. The overall AGREE II scores for the included studies ranged from 3 to 7. The summary of nutritional recommendations was organized into topics: (1) dysphagia, (2) nutritional assessment, (3) energy, (4) protein, (5) supplementation, and (6) percutaneous endoscopic gastrostomy (PEG). This review summarizes relevant and updated nutritional recommendations to maintain or restore the nutritional status of patients with ALS, contributing to their quality of life and survival time. Conclusions: These nutritional recommendations will help health professionals and caregivers to implement and standardize nutritional care according to evidence-based practice in ALS. PROSPERO registration number CRD42021233088.
Prevention of unplanned extubation in neonatal patients: Protocol for a systematic review and meta-analysis Ludmylla Cristina de Faria Pontes, Isac Davidson Santiago Fernandes Pimenta, Gidyenne Christine Bandeira Silva de Medeiros, Daniel Guillén-Martínez, Paloma Echevarria-Pérez, et al. Plos One, 2025 Unplanned extubation (UPE), defined as accidental removal of the endotracheal tube during mechanical ventilation or its replacement due to suspected obstruction or inadequate diameter, is considered the fourth most common adverse event in neonatal intensive care units (NICU). This study aimed to describe a systematic review and meta-analysis protocol that will identify and assess the effect of primary intervention measures designed to prevent UPE in NICU. A search will be carried out in the following databases: PubMed/Medline, EMBASE, Scopus, CINAHL, Cochrane Library, SciELO, and LILACS. Reviewers, in pairs and independently, will select the studies, perform data extraction and assess the methodological quality of the included studies using preestablished tools according to the type of study. The systematic review will provide evidence to present the main intervention measures used in the prevention of UPE during the care of critical neonatal patients. The systematic review and meta-analysis resulting from this protocol may provide important information regarding UPE in the neonatal population, which will help with decision-making and the implementation of safer clinical practices that focus on the reduction of adverse events, contributing to the improvement of service management and the safety of neonatal patients.
Experimental Protocols Used to Mimic Gastrointestinal Protein Digestion: A Systematic Review Anna Beatriz Santana Luz, Amanda Fernandes de Medeiros, Gidyenne Christine Bandeira Silva de Medeiros, Grasiela Piuvezam, Thaís Souza Passos, et al. Nutrients, 2024 Bioactive peptides derived from native proteins modulate physiological processes in the metabolic pathways. Given that multiple protocols in the literature mimic the digestion of dietary components, gathering studies that use such models directed at protein digestion processes is critical. This systematic review aimed to gather evidence that adopted adequate experimental models to simulate human protein digestion. The databases searched were PubMed, Web of Science, ScienceDirect, Embase, Virtual Health Library, and Scopus. A total of 1985 articles were found, resulting in 20 eligible in vitro studies. The Office of Health Assessment and Translation was used to evaluate methodological quality. Seven studies used plant-based protein sources, twelve used animal protein sources, and one used both. The duration of the oral phase varied, although 60% of the studies employed a protein digestion period of 120 min. Amylase, pepsin, and pancreatin enzymes were utilized in 40% of the studies, with pH levels of 7, 3, and 7, respectively, during the oral, gastric, and intestinal phases. The INFOGEST harmonized static model was adopted by 65% of the studies; INFOGEST is the most effective model for simulating gastrointestinal protein processes in humans and can be used to answer several research questions because it describes experimental conditions close to the human physiological situation.
Global prevalence of staphylococcal enterotoxins in food contaminated by Staphylococcus spp.—Systematic review and meta-analysis Juliana Karla Garcia Ribeiro Freitas, Cristiane Fernandes de Assis, Thailla Raquel Moura de Oliveira, Bruno Jonatan de Sousa, Cláudio Márcio de Medeiros Maia, et al. Journal of Food Safety, 2024 This systematic review (SR) and meta‐analysis integrates the results of studies on the occurrence of staphylococcal enterotoxin (SE), the knowledge related to the profile of the foods most often involved, and the types of SE found. The study followed the guidelines of the Preferred Reporting Items for SR and Meta‐Analyses, and its protocol was registered on the PROSPERO platform (CRD42021258223). Primary cross‐sectional studies that report the analysis of SEs in food contaminated by Staphylococcus spp. were selected. All stages of study selection and data extraction were performed by two researchers independently, and in cases of conflicts, a third researcher was consulted. To assess the risk of bias, we used the critical appraisal checklist of the Joanna Briggs Institute. A total of 3012 reports were listed initially and 217 after the search update. After removing the duplicates, 2535 studies were found combining all databases and manual searches. Thus, 38 studies were included in this SR. In the meta‐analysis, group 1 (dairy products) showed a prevalence of positive samples for SE of 15.38%, group 2 (meat products) 1.78% and group 3 (other foods) 27.11%. The results showed a considerable prevalence of SE in food contaminated by Staphylococcus spp., especially in group 3, which included mixed and ready‐to‐eat foods. This SR contributes to the study of the epidemiological profile and highlights the importance of adopting more effective prevention measures and policies aimed at improving public health.
Association between sedentary behavior and Brain-Derived Neurotrophic Factor (BDNF) in children and adolescents: A protocol for systematic review and meta-analysis Victor Hugo de Oliveira Segundo, Kesley Pablo Morais de Azevedo, Gidyenne Christine Bandeira Silva de Medeiros, Ádala Nayana de Sousa Mata, Grasiela Piuvezam Plos One, 2024 Background There is evidence in the literature suggesting that high time spent in sedentary behavior (SB) can reduce the Brain-Derived Neurotrophic Factor (BDNF) levels, an important neurotrophin that plays a role in modulating cognition, learning and memory. Children and adolescents usually spend many hours a day on SB, either sitting for a long time and/or using screen equipment. Objective The aim of this study is to describe a systematic review and meta-analysis protocol on the associations between SB and BDNF levels in children and adolescents. Methods This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols and was published in the International Prospective Register of Systematic Reviews database (PROSPERO: CRD42023392246). The databases that will be searched are EMBASE, Scopus, ScienceDirect, Web of Science, SPORTDiscus, CINAHL, and PubMed. Cross-sectional and cohort studies conducted with children and adolescents (5 to 19 yr) that analyzed the association between SB and BDNF will be included in the systematic review. The characteristics of the studies, methodological aspects, and main results will be described. Then, the risk of bias (assessed by STROBE and Newcastle-Ottawa scales) and the level of evidence (assessed by the GRADE tool) from included studies will be evaluated. Sub-group analysis will also be performed. Two experienced reviewers will perform the studies selection, data extraction, and methodological quality assessment. Conclusion This systematic review and meta-analysis will analyze the association between SB and BDNF in children and adolescents. The results will provide subsidies to better understand this relationship and will strengthen evidence-based practice for both health professionals and future researches.
