Giancarlo Franzese

Scopus Publications

Many-body contributions to polymorphism and polyhexaticity in a water monolayer
Oriol Vilanova, Giancarlo Franzese
Journal of Chemical Physics, 2026
Nanoconfined water plays a crucial role in nanofluidics, biology, and cutting-edge technologies. The process of melting water monolayers and quasi-two-dimensional confined water involves, as an intermediate stage, the hexatic phase—a state that lies between solid and liquid and is characterized by quasi-long-range orientational order and short-range translational order. However, the influence of hydrogen bond (HB) cooperativity in this process has not been thoroughly investigated. This gap hampers our understanding of the phase behavior of confined water and limits the accuracy of our models. To address this, we extend the water model developed by Franzese and Stanley, which explicitly includes many-body interactions (MBIs) of HBs. We distinguish the contributions of three-body and five-body HB-MBIs. Our Monte Carlo calculations in the isobaric–isothermal ensemble produce a detailed pressure–temperature phase diagram, revealing polymorphism and polyhexaticity: low-density square ice and high-density triangular ice are separated from the liquid phase by distinct hexatic phases. Three-body interactions notably promote crystallization and can destabilize the low-density hexatic phase, while cooperative five-body interactions help restore it, thus modifying the thermodynamic landscape. These findings demonstrate that HB-MBIs are key to determining the phase behavior of confined water, influencing phenomena such as non-monotonic specific heat, maximum-density lines, and the accessibility of the liquid–liquid critical point. Beyond advancing theoretical understanding, these results have wide-ranging implications for nanofluidics, interfacial science, and applications in biology, food technology, and pharmaceutics, where controlling water under confinement is essential.
Unveiling the entropic role of hydration water in SOD1 partitioning within FUS condensate
Luis Enrique Coronas, Stepan Timr, Fabio Sterpone, Giancarlo Franzese
Journal of Chemical Physics, 2026
Biological processes such as the sequestration of superoxide dismutase 1 (SOD1) into biomolecular condensates, including fused in sarcoma and stress granules, are vital for understanding disease mechanisms, including amyotrophic lateral sclerosis. Moreover, protein–crowder interactions within these condensates are recognized as fundamental to cellular phase separation and disease-related processes. However, the specific role of the hydration environment in governing SOD1’s behavior and transition dynamics within these condensates remains poorly understood, limiting our ability to accurately model these critical biological systems. Therefore, we incorporate explicit water into an implicit solvent model (OPEP) to investigate how water influences SOD1’s behavior, residence times, and transition rates among associative states. We employ the advanced CVF (Coronas, Vilanova, Franzese) water model, which accurately captures hydrogen-bond networks at the molecular level. While the OPEP model indicates that bovine serum albumin (BSA) crowders reduce SOD1’s partition coefficient (PC) primarily through non-specific interactions, our explicit-water approach points to hydration entropy in BSA as a key contributor to the observed PC reduction. This result offers a new perspective on the system’s free-energy landscape, complementing those obtained from OPEP alone. Our research supports the notion that explicitly modeling water can enhance our understanding of protein–crowder interactions and their biological implications, further emphasizing the potential role of water in cellular phase separation and disease-related processes.
Adsorption of wastewater pollutants on amorphous TiO2: an atomistic simulation study
Maria von Einem, Filippo Balzaretti, Manuela Romero, Wilke Dononelli, Lucio Colombi Ciacchi, Giancarlo Franzese, Susan Köppen-Hannemann
Materials Advances, 2026
The increasing presence of polluting chemicals in man-made wastewater poses significant environmental and health risks. In this work, the potential for removal of selected pollutants is discussed with results of molecular dynamics simulations.
A machine learning tool to analyze spectroscopic changes in high-dimensional data
Alberto Martinez-Serra, Gionni Marchetti, Francesco D’Amico, Ivana Fenoglio, Barbara Rossi, Marco P. Monopoli, Giancarlo Franzese
International Journal of Biological Macromolecules, 2025
When nanoparticles (NPs) are introduced into a biological solution, layers of biomolecules form on their surface, creating a corona. Understanding how the protein's structure evolves into the corona is essential for evaluating the safety and toxicity of nanotechnology. However, the influence of NP properties on protein conformation is not well understood. In this study, we propose a new method that addresses this issue by analyzing multi-component spectral data (UV Resonance Raman, Circular Dichroism, and UV absorbance) using machine learning (ML). We apply the method to fibrinogen, a crucial protein in human blood plasma, at physiological concentrations while interacting with hydrophobic carbon or hydrophilic silicon dioxide NPs, revealing striking differences in the temperature dependence of the protein structure between the two cases. Our unsupervised ML method (a) does not suffer from the challenges associated with the curse of dimensionality, and (b) simultaneously handles spectral data from various sources. The method offers a quantitative analysis of protein structural changes upon adsorption. It enhances the understanding of the correlation between protein structure and NP interactions, which could support the development of nanomedical tools to treat various conditions.
Confinement-driven emergence of hyperuniform fluids
Fabio Leoni, Giancarlo Franzese, Erdal C. Oğuz, Fausto Martelli
Physical Review Research, 2025
Controlling emergent structural order in spatially constrained systems is a fundamental challenge. Using large-scale simulations of a model fluid at equilibrium conditions, we show that geometric confinement alone can stabilize fluid and hyperuniform labyrinthine phases. Moreover, confinement can induce self-assembly into distinct regimes—ranging from nonhyperuniform to antihyperuniform configurations—providing a robust mechanism for tuning spatial order. Our results identify confinement as a minimal design principle for engineering systems with target structural properties, including (anti)hyperuniformity, without relying on genetic or chemical specificity, and with broad applications in multiple disciplines and technologies.
A transferable molecular model for accurate thermodynamic studies of water in large-scale systems
Luis Enrique Coronas, Oriol Vilanova, Giancarlo Franzese
Journal of Molecular Liquids, 2025
Water is essential for life, and its unique properties present significant scientific challenges because of our limited understanding of its thermodynamic behavior. This knowledge gap hinders the accurate theoretical replication of water's properties across various temperatures and pressures, mainly due to the complex quantum nature of its many-body interactions. To address this challenge, we developed a novel molecular model for bulk liquid water that focuses on the hydrogen bond network and its cooperativity. We show that these factors are crucial to controlling water's thermodynamics. Our study introduces an innovative strategy to derive many-body parameters from quantum calculations, validated by advanced polarizable models and calibrated with experimental data under ambient conditions. Our results demonstrate that this model accurately predicts water's equation of state and response functions over a temperature range of approximately 60 degrees at atmospheric pressure and around 40 degrees up to 50 MPa. This quantitative validation underscores the model's reliability and transferability, providing new insights into water's cooperative fluctuations across a broader range of thermodynamic conditions than previously achieved. Moreover, our model's computational efficiency allows for scalability in simulating water droplets nearing micrometer sizes without extensive computational resources or long simulation times. This breakthrough holds significant theoretical and technological implications, opening avenues for advanced research across various scientific fields and applications. • The CVF water model includes cooperativity with ab initio-based parametrization. • Reliable: thermodynamically accurate for liquid water up to 50 MPa. • Efficient: for parallel Monte Carlo algorithms. • Scalable: up to 10 million water molecules on a GPU. • Transferable: even in the supercooled region.
Efficient parallel algorithms for Monte Carlo simulations of millions of water molecules in the fluid phase
Luis Enrique Coronas, Oriol Vilanova, Giancarlo Franzese
Frontiers in Nanotechnology, 2025
Simulating water droplets made up of millions of molecules and on timescales as needed in biological and technological applications is challenging due to the difficulty of balancing accuracy with computational capabilities. Most detailed descriptions, such as ab initio, polarizable, or rigid models, are typically constrained to a few hundred (for ab initio) or thousands of molecules (for rigid models). Recent machine learning approaches allow for the simulation of up to 4 million molecules with ab initio accuracy but only for tens of nanoseconds, even if parallelized across hundreds of GPUs. In contrast, coarse-grained models permit simulations on a larger scale but at the expense of accuracy or transferability. Here, we consider the CVF molecular model of fluid water, which bridges the gap between accuracy and efficiency for free-energy and thermodynamic quantities due to i) a detailed calculation of the hydrogen bond contributions at the molecular level, including cooperative effects, and ii) coarse-graining of the translational and rotational degrees of freedom of the molecules. The CVF model can reproduce the experimental equation of state and fluctuations of fluid water across a temperature range of 60° around ambient temperature and from 0 to 50 MPa. In this work, we describe efficient parallel Monte Carlo algorithms executed on GPUs using CUDA, tailored explicitly for the CVF model. We benchmark accessible sizes of 17 million molecules with the Metropolis and 2 million with the Swendsen-Wang Monte Carlo algorithm.
Editorial: Emerging leaders in nanotechnology
Marcos H. D. Guimaraes, Simona Badilescu, Satyabrata Mohapatra, Giancarlo Franzese
Frontiers in Nanotechnology, 2025
The study by Z. Dan et al., led by Antonija Grubisic-Cabo, explores the scalable production of highquality two-dimensional transition metal dichalcogenide (TMD) monolayers, namely WS₂ and WSe₂, using the kinetic in situ single-layer synthesis (KISS) method. The authors show the influence of different substrates (Au, Ag) and TMD chalcogen elements (S, Se) on the film quality and dimensions, with WSe₂ consistently yielding larger monolayers than WS₂, independent of substrate. Structural and chemical analyses confirmed high crystallinity and non-destructive exfoliation, without any covalent bonding to substrates. This work particularly highlights the use of the KISS method to obtain large high quality TMD monolayers which can be used in fundamental and applied research using these promising nanomaterials.The collection presents two papers examining the formation of a biomolecular corona on nanoparticles (NPs) upon exposure to the bloodstream or biological fluids. This phenomenon is crucial for understanding the potential applications of NPs in therapies and evaluating their safety. It involves the rapid adsorption of proteins, lipids, and sugars onto the particle surface, and studying its evolution over time is the focus of extensive experimental research. Theoretical work on adsorption kinetics and corona evolution is limited and often tied to simulation outcomes. The first paper on NP-corona formation presented here offers a theoretical perspective based on a simplified model, aiming to bridge this knowledge gap. Åberg Christoffer and Jansen Alwin explore the kinetics of corona formation, the variability of corona composition across different particles, and the spatial distribution of various biomolecules within the corona. Their assumptions include irreversibility of adsorption and the lack of biomolecule-biomolecule interactions. They suggest this approach as a valuable reference for experiments and future theoretical investigations.The second paper on NP-corona formation -by E. Clemente et al. and led by Marco P. Monopoli -is an original experimental study that aims to control the process for enhancing NP biocompatibility and extend circulation time by minimizing protein adsorption. To achieve this goal, surface modifications using polyethylene glycol (PEG) polymers are typically employed due to their steric hindrance and repulsion effects. However, continuous exposure to PEGylated NPs can trigger both acute and chronic immune responses, which limits their use in treating various conditions. The authors of this contribution suggest an alternative strategy using monosaccharide (glycans) coatings Glycans are biocompatible, interact with biological receptors in the body, and can be conjugated to control their orientation, which enhances NP stability in solution due to their hydrophilic nature. Specifically, they developed a series of gold NPs (AuNPs) that are coated with PEG linkers of varying lengths and conjugated with mannose (Man) or sialic acid (Sia) glycans, meticulously characterizing them before and after exposure to biological fluids. The results suggest that coating impacts the formation of the protein corona, but it does not affect the interaction with glycan receptors, even within a complex protein environment. Thus, glycan modification of PEGylated NPs minimizes nonspecific interactions while maintaining active targeting properties, highlighting their potential for therapeutic applications.The paper authored by A. Czajkowski, et al., and led by Ellen M. Adams, focuses on a unique aspect of protein organization in cells: the formation of biomolecular condensates. These condensates can form spontaneously in vivo in response to external stresses or to fulfill essential biological functions. They consist of solvated RNA-binding proteins, often incorporating nucleic acids. In this study, the authors examine how post-translational modifications (PTMs) and salt concentration influence the protein Fused in Sarcoma (FUS) in terms of its tendency to form biomolecular condensates. They utilize two expression systems-bacterial and insect cells-that differ in their ability to incorporate PTMs into the protein, and they analyze the solvation of FUS condensates, both with and without PTMs, at 100 mM and 2.5 M KCl using attenuated total reflection Terahertz spectroscopy. The findings indicate that PTMs significantly affect the phaseseparation propensity, whereas protein solvation within the condensate remains unaffected. Conversely, variations in salt concentration modify the stiffness of the water hydrogen bond network, causing perturbations in the molecular organization of the condensate due to changes in solvent properties.The study by Sakinala et al., headed by Mallesham Baithy , explores the development of Cusupported doped-CeO2 catalysts and their application in the oxidation of benzylamine, both in the absence and presence of 1,2-diaminobenzene. The authors show that the prepared CuO/CeO2 -ZrO2 catalyst offers a highly efficient, robust, and recyclable system for the selective oxidative coupling of benzylamines to imine (99.5%), benzimidazole (99.2%) and its derivatives under solvent-free conditions. The catalytic activity is influenced by the presence of oxygen vacancy sites, strong metal support interaction, enhanced redox behavior and a high density of acidic sites, which collectively contribute to its superior performance. This study highlights the importance and necessity for further studies on ceria-based catalysts in oxidative processes.Together, these contributions illustrate the multifaceted nature of nanotechnology research, highlighting the work led by emerging scientists in the field. From innovative synthesis methods and theoretical insights to biocompatible nanomaterials and ethical considerations in education, this special issue highlights the creativity and interdisciplinary spirit driving the next generation of discoveries in nanoscience and nanotechnology.
Phase behavior of metastable water from large-scale simulations of a quantitatively accurate model near ambient conditions: The liquid–liquid critical point
Luis Enrique Coronas, Giancarlo Franzese
Journal of Chemical Physics, 2024
The molecular mechanisms of water’s unique anomalies are still debated upon. Experimental challenges have led to simulations suggesting a liquid–liquid (LL) phase transition, culminating in the supercooled region’s LL critical point (LLCP). Computational expense, small system sizes, and the reliability of water models often limit these simulations. We adopt the CVF model, which is reliable, transferable, scalable, and efficient across a wide range of temperatures and pressures around ambient conditions. By leveraging the timescale separation between fast hydrogen bonds and slow molecular coordinates, the model allows a thorough exploration of the metastable phase diagram of liquid water. Using advanced numerical techniques to bypass dynamical slowing down, we perform finite-size scaling on larger systems than those used in previous analyses. Our study extrapolates thermodynamic behavior in the infinite-system limit, demonstrating the existence of the LLCP in the 3D Ising universality class in the low-temperature, low-pressure side of the line of temperatures of maximum density, specifically at TC = 186 ± 4 K and PC = 174 ± 14 MPa, at the end of a liquid–liquid phase separation stretching up to ∼200 MPa. These predictions align with recent experimental data and sophisticated models, highlighting that hydrogen bond cooperativity governs the LLCP and the origin of water anomalies. We also observe substantial cooperative fluctuations in the hydrogen bond network at scales larger than 10 nm, even at temperatures relevant to biopreservation. These findings have significant implications for nanotechnology and biophysics, providing new insights into water’s behavior under varied conditions.
Small-angle X-ray scattering unveils the internal structure of lipid nanoparticles
Francesco Spinozzi, Paolo Moretti, Diego Romano Perinelli, Giacomo Corucci, Paolo Piergiovanni, Heinz Amenitsch, Giulio Alfredo Sancini, Giancarlo Franzese, Paolo Blasi
Journal of Colloid and Interface Science, 2024
Lipid nanoparticles own a remarkable potential in nanomedicine, only partially disclosed. While the clinical use of liposomes and cationic lipid-nucleic acid complexes is well-established, liquid lipid nanoparticles (nanoemulsions), solid lipid nanoparticles, and nanostructured lipid carriers have even greater possibilities. However, they face obstacles in being used in clinics due to a lack of understanding about the molecular mechanisms controlling their drug loading and release, interactions with the biological environment (such as the protein corona), and shelf-life stability. To create effective drug delivery carriers and successfully translate bench research to clinical settings, it is crucial to have a thorough understanding of the internal structure of lipid nanoparticles. Through synchrotron small-angle X-ray scattering experiments, we determined the spatial distribution and internal structure of the nanoparticles' lipid, surfactant, and the bound water in them. The nanoparticles themselves have a barrel-like shape that consists of coplanar lipid platelets (specifically cetyl palmitate) that are covered by loosely spaced polysorbate 80 surfactant molecules, whose polar heads retain a large amount of bound water. To reduce the interface cost of bound water with unbound water without stacking, the platelets collapse onto each other. This internal structure challenges the classical core-shell model typically used to describe solid lipid nanoparticles and could play a significant role in drug loading and release, biological fluid interaction, and nanoparticle stability, making our findings valuable for the rational design of lipid-based nanoparticles.
Editorial of virtual special issue EMLG/JMLG 2022: Molecular liquids at interfaces
Giancarlo Franzese, Thierry Tassaing, Lourdes F. Vega
Journal of Molecular Liquids, 2024
Characterizing the hard and soft nanoparticle-protein corona with multilayer adsorption
Oriol Vilanova, Alberto Martinez-Serra, Marco P. Monopoli, Giancarlo Franzese
Frontiers in Nanotechnology, 2024
Exploring optimal graphene slit-pore width for the physical separation of water-methanol mixture
Roger Bellido-Peralta, Fabio Leoni, Carles Calero, Giancarlo Franzese
Journal of Molecular Liquids, 2023
Hydrophobic Homopolymer’s Coil-Globule Transition and Adsorption onto a Hydrophobic Surface under Different Conditions
Bernat Durà Faulí, Valentino Bianco, Giancarlo Franzese
Journal of Physical Chemistry B, 2023
Correction to: Protein Unfolding and Aggregation near a Hydrophobic Interface (Polymers, (2021), 13, 1, (156), 10.3390/polym13010156)
David March, Valentino Bianco, Giancarlo Franzese
Polymers, 2023
Size–Pore-Dependent Methanol Sequestration from Water–Methanol Mixtures by an Embedded Graphene Slit
Roger Bellido-Peralta, Fabio Leoni, Carles Calero, Giancarlo Franzese
Molecules, 2023
Many-Body Contributions in Water Nanoclusters
David Abella, Giancarlo Franzese, Javier Hernández-Rojas
ACS Nano, 2023
Interfacial phenomena in nanotechnological applications for water remediation
M.J. Esplandiu, N. Bastus, J. Fraxedas, I. Ihmaz, V. Puntes, J. Radjenovic, B. Sepúlveda, A. Serrá, S. Suárez-García, G. Franzese
Encyclopedia of Solid Liquid Interfaces, 2023
Using Car-Parrinello simulations and microscopic order descriptors to reveal two locally favored structures with distinct molecular dipole moments and dynamics in ambient liquid water
Ioannis Skarmoutsos, Giancarlo Franzese, Elvira Guardia
Journal of Molecular Liquids, 2022
Water Contribution to the Protein Folding and Its Relevance in Protein Design and Protein Aggregation
Giancarlo Franzese, Joan Àguila Rojas, Valentino Bianco, Ivan Coluzza
Springer Proceedings in Physics, 2022
The Franzese-Stanley Coarse Grained Model for Hydration Water
Luis Enrique Coronas, Oriol Vilanova, Valentino Bianco, Francisco de los Santos, Giancarlo Franzese
Properties of Water from Numerical and Experimental Perspectives, 2022
Nanoconfined Fluids: Uniqueness of Water Compared to Other Liquids
Fabio Leoni, Carles Calero, Giancarlo Franzese
ACS Nano, 2021
Structure and dynamics of nanoconfined water and aqueous solutions
Horacio R. Corti, Gustavo A. Appignanesi, Marcia C. Barbosa, J. Rafael Bordin, Carles Calero, Gaia Camisasca, M. Dolores Elola, Giancarlo Franzese, Paola Gallo, Ali Hassanali, Kai Huang, Daniel Laria, Cintia A. Menéndez, Joan M. Montes de Oca, M. Paula Longinotti, Javier Rodriguez, Mauro Rovere, Damián Scherlis, Igal Szleifer
European Physical Journal E, 2021
Advances in the study of supercooled water
Paola Gallo, Johannes Bachler, Livia E. Bove, Roland Böhmer, Gaia Camisasca, Luis E. Coronas, Horacio R. Corti, Ingrid de Almeida Ribeiro, Maurice de Koning, Giancarlo Franzese, Violeta Fuentes-Landete, Catalin Gainaru, Thomas Loerting, Joan Manuel Montes de Oca, Peter H. Poole, Mauro Rovere, Francesco Sciortino, Christina M. Tonauer, Gustavo A. Appignanesi
European Physical Journal E, 2021
Redefining the concept of hydration water near soft interfaces
Fausto Martelli, Carles Calero, Giancarlo Franzese
Biointerphases, 2021
Protein unfolding and aggregation near a hydrophobic interface
David March, Valentino Bianco, Giancarlo Franzese
Polymers, 2021
Water under extreme confinement in graphene: Oscillatory dynamics, structure, and hydration pressure explained as a function of the confinement width
Carles Calero, Giancarlo Franzese
Journal of Molecular Liquids, 2020
Network Topology in Water Nanoconfined between Phospholipid Membranes
Fausto Martelli, Jason Crain, Giancarlo Franzese
ACS Nano, 2020
In Silico Evidence That Protein Unfolding is a Precursor of Protein Aggregation
Valentino Bianco, Giancarlo Franzese, Ivan Coluzza
Chemphyschem, 2020
Editorial of virtual special issue Frontiers in Water Biophysics 2017
Marco Paolantoni, Attilio Cesàro, Lucia Comez, Giancarlo Franzese
Journal of Molecular Liquids, 2019
Hydrogen bond correlated percolation in a supercooled water monolayer as a hallmark of the critical region
Valentino Bianco, Giancarlo Franzese
Journal of Molecular Liquids, 2019
Membranes with different hydration levels: The interface between bound and unbound hydration water
Carles Calero, Giancarlo Franzese
Journal of Molecular Liquids, 2019
Multi-scale approach for self-assembly and protein folding
Oriol Vilanova, Valentino Bianco, Giancarlo Franzese
Design of Self Assembling Materials, 2018
Structural properties of water confined by phospholipid membranes
Fausto Martelli, Hsin-Yu Ko, Carles Calero Borallo, Giancarlo Franzese
Frontiers of Physics, 2018
How the stability of a folded protein depends on interfacial water properties and residue-residue interactions
Valentino Bianco, Neus Pagès-Gelabert, Ivan Coluzza, Giancarlo Franzese
Journal of Molecular Liquids, 2017
Nonequilibrium Phenomena in Confined Systems
Giancarlo Franzese, Ivan Latella, J. Rubi
Entropy, 2017
Role of water in the selection of stable proteins at ambient and extreme thermodynamic conditions
Valentino Bianco, Giancarlo Franzese, Christoph Dellago, Ivan Coluzza
Physical Review X, 2017
Structure and dynamics of water at carbon-based interfaces
Jordi Martí, Carles Calero, Giancarlo Franzese
Entropy, 2017
Understanding the Kinetics of Protein-Nanoparticle Corona Formation
Oriol Vilanova, Judith J. Mittag, Philip M. Kelly, Silvia Milani, Kenneth A. Dawson, Joachim O. Rädler, Giancarlo Franzese
ACS Nano, 2016
Effects of confinement between attractive and repulsive walls on the thermodynamics of an anomalous fluid
Fabio Leoni, Giancarlo Franzese
Physical Review E, 2016
Structural interpretation of the large slowdown of water dynamics at stacked phospholipid membranes for decreasing hydration level: All-atom molecular dynamics
Carles Calero, H. Stanley, Giancarlo Franzese
Materials, 2016
Contribution of Water to Pressure and Cold Denaturation of Proteins
Valentino Bianco, Giancarlo Franzese
Physical Review Letters, 2015
Optimization of crystal nucleation close to a metastable fluid-fluid phase transition
Jan Wedekind, Limei Xu, Sergey V. Buldyrev, H. Eugene Stanley, David Reguera, Giancarlo Franzese
Scientific Reports, 2015
Two types of dynamic crossovers in a network-forming liquid with tetrahedral symmetry
Sergey V. Buldyrev, Giancarlo Franzese
Journal of Non Crystalline Solids, 2015
Structural behavior and dynamics of an anomalous fluid between attractive and repulsive walls: Templating, molding, and superdiffusion
Fabio Leoni, Giancarlo Franzese
Journal of Chemical Physics, 2014
Critical behavior of a water monolayer under hydrophobic confinement
Valentino Bianco, Giancarlo Franzese
Scientific Reports, 2014
Polyamorphism and polymorphism of a confined water monolayer: Liquid-liquid critical point, liquid-crystal and crystal-crystal phase transitions
Valentino Bianco, Oriol Vilanova, Giancarlo Franzese
Perspectives and Challenges in Statistical Physics and Complex Systems for the Next Decade, 2014
Water at Biological and Inorganic Interfaces
Giancarlo Franzese, Valentino Bianco
Food Biophysics, 2013
Understanding and modulating the competitive surface-adsorption of proteins through coarse-grained molecular dynamics simulations
Pol Vilaseca, Kenneth A. Dawson, Giancarlo Franzese
Soft Matter, 2013
Finite-size scaling investigation of the liquid-liquid critical point in ST2 water and its stability with respect to crystallization
T. A. Kesselring, E. Lascaris, G. Franzese, S. V. Buldyrev, H. J. Herrmann, H. E. Stanley
Journal of Chemical Physics, 2013
Response functions near the liquid-liquid critical point of ST2 water
Erik Lascaris, T. A. Kesselring, G. Franzese, S. V. Buldyrev, H. J. Herrmann, H. E. Stanley
Aip Conference Proceedings, 2013
Water and anomalous liquids
Proceedings of the International School of Physics Enrico Fermi, 2012
Effect of pressure on the anomalous response functions of a confined water monolayer at low temperature
Marco G. Mazza, Kevin Stokely, H. Eugene Stanley, Giancarlo Franzese
Journal of Chemical Physics, 2012
Confinement of anomalous liquids in nanoporous matrices
Elena G. Strekalova, Jiayuan Luo, H. Eugene Stanley, Giancarlo Franzese, Sergey V. Buldyrev
Physical Review Letters, 2012
Homogeneous crystal nucleation near a metastable fluid-fluid phase transition
Limei Xu, Sergey V. Buldyrev, H. Eugene Stanley, Giancarlo Franzese
Physical Review Letters, 2012
Nanoscale dynamics of phase flipping in water near its hypothesized liquid-liquid critical point
T. A. Kesselring, G. Franzese, S. V. Buldyrev, H. J. Herrmann, H. E. Stanley
Scientific Reports, 2012
Hydrophobic nanoconfinement suppresses fluctuations in supercooled water
E G Strekalova, M G Mazza, H E Stanley, G Franzese
Journal of Physics Condensed Matter, 2012
Relations between the diffusion anomaly and cooperative rearranging regions in a hydrophobically nanoconfined water monolayer
Francisco de los Santos, Giancarlo Franzese
Physical Review E Statistical Nonlinear and Soft Matter Physics, 2012
Understanding the role of hydrogen bonds in water dynamics and protein stability
Valentino Bianco, Svilen Iskrov, Giancarlo Franzese
Journal of Biological Physics, 2012
Effect of hydrophobic environments on the hypothesized liquid-liquid critical point of water
Elena G. Strekalova, Dario Corradini, Marco G. Mazza, Sergey V. Buldyrev, Paola Gallo, Giancarlo Franzese, H. Eugene Stanley
Journal of Biological Physics, 2012
More than one dynamic crossover in protein hydration water
Marco G. Mazza, Kevin Stokely, Sara E. Pagnotta, Fabio Bruni, H. Eugene Stanley, Giancarlo Franzese
Proceedings of the National Academy of Sciences of the United States of America, 2011
Understanding diffusion and density anomaly in a coarse-grained model for water confined between hydrophobic walls
Francisco de los Santos, Giancarlo Franzese
Journal of Physical Chemistry B, 2011
Water at Interface with Proteins
Giancarlo Franzese, Valentino Bianco, Svilen Iskrov
Food Biophysics, 2011
Large decrease of fluctuations for supercooled water in hydrophobic nanoconfinement
Elena G. Strekalova, Marco G. Mazza, H. Eugene Stanley, Giancarlo Franzese
Physical Review Letters, 2011
Isotropic soft-core potentials with two characteristic length scales and anomalous behaviour
Pol Vilaseca, Giancarlo Franzese
Journal of Non Crystalline Solids, 2011
Water in nanoconfined and biological environments: (Plenary Talk, Ngai-Ruocco 2009 IDMRCS Conf.)
H.E. Stanley, S.V. Buldyrev, P. Kumar, F. Mallamace, M.G. Mazza, K. Stokely, L. Xu, G. Franzese
Journal of Non Crystalline Solids, 2011
Softness dependence of the anomalies for the continuous shouldered well potential
Pol Vilaseca, Giancarlo Franzese
Journal of Chemical Physics, 2010
Correlated randomness and switching phenomena
H.E. Stanley, S.V. Buldyrev, G. Franzese, S. Havlin, F. Mallamace, P. Kumar, V. Plerou, T. Preis
Physica A Statistical Mechanics and Its Applications, 2010
Phase transitions and dynamics of bulk and interfacial water
G Franzese, A Hernando-Martínez, P Kumar, M G Mazza, K Stokely, E G Strekalova, F de los Santos, H E Stanley
Journal of Physics Condensed Matter, 2010
Liquid polymorphism: Water in nanoconfined and biological environments
H E Stanley, S V Buldyrev, G Franzese, P Kumar, F Mallamace, M G Mazza, K Stokely, L Xu
Journal of Physics Condensed Matter, 2010
Effect of hydrogen bond cooperativity on the behavior of water
Kevin Stokely, Marco G. Mazza, H. Eugene Stanley, Giancarlo Franzese
Proceedings of the National Academy of Sciences of the United States of America, 2010
Understanding the unusual properties of water
Campins, Humberto, Drake, Michael J.
Water and Life the Unique Properties of H2o, 2010
Metastable water under pressure
Kevin Stokely, Marco G. Mazza, H. Eugene Stanley, Giancarlo Franzese
NATO Science for Peace and Security Series A Chemistry and Biology, 2010
Heterogeneities in confined water and protein hydration water
H E Stanley, P Kumar, S Han, M G Mazza, K Stokely, S V Buldyrev, G Franzese, F Mallamace, L Xu
Journal of Physics Condensed Matter, 2009
Influence of intramolecular couplings in a model for hydrogen-bonded liquids
Francisco de los Santos, Giancarlo Franzese, Joaquín Marro, Pedro L. Garrido, Pablo I. Hurtado
Aip Conference Proceedings, 2009
Cluster Monte Carlo and numerical mean field analysis for the water liquid-liquid phase transition
Marco G. Mazza, Kevin Stokely, Elena G. Strekalova, H. Eugene Stanley, Giancarlo Franzese
Computer Physics Communications, 2009
Dynamically slow processes in supercooled water confined between hydrophobic plates
Giancarlo Franzese, Francisco de los Santos
Journal of Physics Condensed Matter, 2009
Liquid polyamorphism and the anomalous behavior of water
H. E. Stanley, S. V. Buldyrev, S.-H. Chen, G. Franzese, S. Han, P. Kumar, F. Mallamace, M. G. Mazza, L. Xu, Z. Yan
Advances in Solid State Physics, 2009
Dynamics of water at low temperatures and implications for biomolecules
P. Kumar, G. Franzese, S.V. Buldyrev, H.E. Stanley
Lecture Notes in Physics, 2008
Pressure effects in supercooled water: Comparison between a 2D model of water and experiments for surface water on a protein
Giancarlo Franzese, Kevin Stokely, Xiang-qiang Chu, Pradeep Kumar, Marco G Mazza, Sow-Hsin Chen, H Eugene Stanley
Journal of Physics Condensed Matter, 2008
Liquid polyamorphism: Possible relation to the anomalous behaviour of water
H. E. Stanley, P. Kumar, G. Franzese, L. Xu, Z. Yan, M. G. Mazza, S. V. Buldyrev, S.-H. Chen, F. Mallamace
European Physical Journal Special Topics, 2008
Dynamics and thermodynamics of water
Pradeep Kumar, Giancarlo Franzese, H Eugene Stanley
Journal of Physics Condensed Matter, 2008
Liquid polyamorphism: Some unsolved puzzles of water in bulk, nanoconfined, and biological environments
H. E. Stanley, Pradeep Kumar, Giancarlo Franzese, Limei Xu, Zhenyu Yan, Marco G. Mazza, S.-H. Chen, F. Mallamace, S. V. Buldyrev, Michio Tokuyama, Irwin Oppenheim, Hideya Nishiyama
Aip Conference Proceedings, 2008
Predictions of dynamic behavior under pressure for two scenarios to explain water anomalies
Pradeep Kumar, Giancarlo Franzese, H. Eugene Stanley
Physical Review Letters, 2008
Waterlike hierarchy of anomalies in a continuous spherical shouldered potential
Alan Barros de Oliveira, Giancarlo Franzese, Paulo A. Netz, Marcia C. Barbosa
Journal of Chemical Physics, 2008
Differences between discontinuous and continuous soft-core attractive potentials: The appearance of density anomaly
Giancarlo Franzese
Journal of Molecular Liquids, 2007
The Widom line of supercooled water
Giancarlo Franzese, H Eugene Stanley
Journal of Physics Condensed Matter, 2007
Molecular dynamics study of orientational cooperativity in water
Pradeep Kumar, Giancarlo Franzese, Sergey V. Buldyrev, H. Eugene Stanley
Physical Review E Statistical Nonlinear and Soft Matter Physics, 2006
Liquid-liquid phase transition for an attractive isotropic potential with wide repulsive range
Gianpietro Malescio, Giancarlo Franzese, Anna Skibinsky, Sergey V. Buldyrev, H. Eugene Stanley
Physical Review E Statistical Nonlinear and Soft Matter Physics, 2005
Dynamic response limits of an elastic magnet
G. Ausanio, L. De Arcangelis, G. Franzese, V. Iannotti, C. Luponio Jr., L. Lanotte
Journal of Magnetism and Magnetic Materials, 2005
Static and dynamic heterogeneities in water
H. Eugene Stanley, Sergey V. Buldyrev, Giancarlo Franzese, Nicolas Giovambattista, Francis W. Starr
Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, 2005
Liquid-liquid phase transitions for soft-core attractive potentials
A. Skibinsky, S. V. Buldyrev, G. Franzese, G. Malescio, H. E. Stanley
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 2004
Liquid-liquid phase transitions for soft-core attractive potentials
A. Skibinsky, S. V. Buldyrev, G. Franzese, G. Malescio, H. E. Stanley
Physical Review E Statistical Nonlinear and Soft Matter Physics, 2004
Parity-dependent Kondo effect in ultrasmall metallic grains
G Franzese, R Raimondi, R Fazio
Europhysics Letters, 2003
Fast relaxation time in a spin model with glassy behavior
GIANCARLO FRANZESE
Fractals, 2003
Intramolecular coupling as a mechanism for a liquid-liquid phase transition
Physical Review E Statistical Nonlinear and Soft Matter Physics, 2003
Intramolecular coupling as a mechanism for a liquid-liquid phase transition
Giancarlo Franzese, Manuel I. Marqués, H. Eugene Stanley
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 2003
A theory for discriminating the mechanism responsible for the water density anomaly
Giancarlo Franzese, H. Eugene Stanley
Physica A Statistical Mechanics and Its Applications, 2002
Metastable liquid-liquid phase transition in a single-component system with only one crystal phase and no density anomaly
G. Franzese, G. Malescio, A. Skibinsky, S. V. Buldyrev, H. E. Stanley
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 2002
Liquid-liquid critical point in a Hamiltonian model for water: Analytic solution
Giancarlo Franzese, H Eugene Stanley
Journal of Physics Condensed Matter, 2002
Liquid-liquid phase transition in one-component fluids
Gianpietro Malescio, Giancarlo Franzese, Giuseppe Pellicane, Anna Skibinsky, Sergey V Buldyrev, H Eugene Stanley
Journal of Physics Condensed Matter, 2002
Models for a liquid-liquid phase transition
S.V. Buldyrev, G. Franzese, N. Giovambattista, G. Malescio, M.R. Sadr-Lahijany, A. Scala, A. Skibinsky, H.E. Stanley
Physica A Statistical Mechanics and Its Applications, 2002
Generic mechanism for generating a liquid-liquid phase transition
Giancarlo Franzese, Gianpietro Malescio, Anna Skibinsky, Sergey V. Buldyrev, H. Eugene Stanley
Nature, 2001
Fully frustrated XY model with next-nearest-neighbor interaction
Giancarlo Franzese, Vittorio Cataudella, S. E. Korshunov, Rosario Fazio
Physical Review B Condensed Matter and Materials Physics, 2000
Potts fully frustrated model: Thermodynamics, percolation, and dynamics in two dimensions
Giancarlo Franzese
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 2000
How the next-nearest-neighbor interactions change the phase diagram of a fully frustrated XY model?
Vittorio Cataudella, Giancarlo Franzese, S.E Korshunov, Rosario Fazio
Physica B Condensed Matter, 2000
Precursor phenomena in frustrated systems
Giancarlo Franzese, Antonio Coniglio
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 1999
The Potts frustrated model: Relations with glasses
Giancarlo Franzese, Antonio Coniglio
Philosophical Magazine B Physics of Condensed Matter Statistical Mechanics Electronic Optical and Magnetic Properties, 1999
Percolation transition and the onset of nonexponential relaxation in fully frustrated models
Annalisa Fierro, Giancarlo Franzese, Antonio de Candia, Antonio Coniglio
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 1999
Autocorrelation functions in 3D fully frustrated systems
G. Franzese, A. Fierro, A. De Candia, A. Coniglio
Physica A Statistical Mechanics and Its Applications, 1998
Phase transitions in the potts spin-glass model
Giancarlo Franzese, Antonio Coniglio
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 1998
Invaded cluster dynamics for frustrated models
Giancarlo Franzese, Vittorio Cataudella, Antonio Coniglio
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 1998
Cluster analysis for percolation on a two-dimensional fully frustrated system
Giancarlo Franzese
Journal of Physics A Mathematical and General, 1996
Percolation and cluster Monte Carlo dynamics for spin models
V. Cataudella, G. Franzese, M. Nicodemi, A. Scala, A. Coniglio
Physical Review E Statistical Physics Plasmas Fluids and Related Interdisciplinary Topics, 1996
Generalized percolation models for frustrated spin systems
V. Cataudella, G. Franzese, M. Nicodemi, A. Scala, A. Coniglio
Il Nuovo Cimento D, 1994
Critical clusters and efficient dynamics for frustrated spin models
V. Cataudella, G. Franzese, M. Nicodemi, A. Scala, A. Coniglio
Physical Review Letters, 1994

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