George Mihail Vlasceanu

@upb.ro

Faculty of Medical Engineering, Department of Bioengineering and Biotechnology
National University of Science and Technology POLITEHNICA Bucharest

George Mihail Vlasceanu


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https://researchid.co/george.vlasceanu

RESEARCH, TEACHING, or OTHER INTERESTS

Biomedical Engineering, Biomaterials, Bioengineering, Multidisciplinary
48

Scopus Publications

1449

Scholar Citations

21

Scholar h-index

29

Scholar i10-index

Scopus Publications

  • 3D printing of multicomponent polymeric inks enables hierarchical hybrid architectures for bone tissue regeneration
    Elena Cojocaru, Elena-Alina Chiticaru, George Mihail Vlăsceanu, Mădălina-Cristina Nicolae, Roxana-Cristina Popescu, Mihaela-Raluca Dobrişan, Georgian-Alin Toader, Mariana Ioniță
    Materials Today Advances, 2026
    Bone defects arising due to trauma, disease, or surgical resections continue to constitute serious clinical challenges, demanding more advanced and customizable solutions that not only ensure structural stability, but also replicate the anisotropy and biomimetic complexity of the native bone tissue. In this context, we present a solution that is based on 3D printed scaffolds made of gellan gum (GG) and cellulose nanofibrils (CNFs), reinforced with electrospun chitosan/polyethylene oxide nanofibers (NFs). First, we optimized the base ink by selecting the proper GG/CNFs ratio as 3/1 after evaluating its rheological properties, printability, and scaffold morphology. Next, various concentrations of NFs (0.5, 1, 2, and 4 wt%) were added to the base ink, and the resulting formulations were again evaluated in terms of rheology and printability, while the subsequent printed scaffolds were investigated by scanning electron microscopy and micro-computed tomography, showing a well-organized internal architecture with interconnected pores and improved volumetric fidelity, especially for 2 % NFs addition (GCN-2.0), which recorded the highest total porosity (90.7 %). Structural characterization confirmed the successful integration of NFs within the polymeric matrix, while nanomechanical indentation revealed an increase in storage modulus (72.5 kPa for GCN-2.0) compared to the control (47.5 kPa) and also mechanical anisotropy due to filament orientation and NFs alignment within the printed structures. In vitro swelling and degradation studies showed the highest increase in water uptake capacity and long-term stability (up to 12 weeks) for GCN-2.0, while biological evaluation demonstrated good cytocompatibility with MG-63 cells for all samples and increased mineralization in the scaffolds with higher NFs content. Overall, the results indicate that 2 % NFs reinforcement constitutes the ideal balance between printability, nanomechanical properties, and biological response, indicating a great potential for this hybrid formulation to be used successfully in bone tissue engineering. • Developed gellan-gum/cellulose nanofibrils scaffolds reinforced with electrospun chitosan/polyethylene oxide nanofibers. • Nanofibers addition tailored rheology, print fidelity, and pore interconnectivity. • Achieved tunable swelling and degradation via nanofibers concentration control. • Morpho-structural characterization revealed optimal properties for scaffolds with 2 % nanofibers reinforcement. • 3D printed scaffolds enhanced cell adhesion and proliferation for bone repair.
  • Formulation and Characterization of Hydrogel Based on Pectin, Collagen, Alginate and Myrtus communis Essential Oil for Applications in Skin Regeneration
    Maria Minodora Marin, Janina-Ersilia Iancu, Petru Alexandru Vlaicu, Durmus Alpaslan Kaya, Madalina Georgiana Albu Kaya, Roxana Rodica Constantinescu, Diana Ionela Popescu, George Mihail Vlasceanu, Bianca-Maria Tihăuan, Maria-Luiza Mircea, Daniela-Mihaela Grigore, Madalina Ignat
    Applied Sciences Switzerland, 2026
    This paper proposes a potential solution to the current issue of developing advanced, biocompatible biomaterials with integrated therapeutic functionality, which would contribute to improving the treatment of skin defects. This study aimed to develop, characterize and evaluate hydrogels based on type I collagen, pectin, alginate and myrtle essential oil, in order to obtain biomaterials with potential in skin regeneration applications. Hydrogels incorporating alginate, pectin, type I collagen and Myrtus communis essential oil were prepared via a multistep procedure comprising homogenization, crosslinking and lyophilization. The obtained hydrogels were characterized by physicochemical and structural methods, such as FTIR spectroscopy, to identify interactions between components; micro-computed tomography, to evaluate internal morphology and porosity; antibacterial tests, for evaluating the ability of the hydrogel to prevent infections at the application site; and in vitro cellular tests, such as the XTT test or cytotoxicity tests, such as LDH, essential for evaluating the biocompatibility of the hydrogel. The highest viability value was recorded for sample J4 (99.53 ± 11.88%), indicating an exceptional compatibility with the cells used, almost identical to that of the untreated control. The samples showed encouraging results, supporting their potential for applications in wound treatment and skin regeneration.
  • Functionalized Reduced Graphene Oxide-Based Nanocomposite Hydrogels for Enhanced Osteogenesis in Bone Tissue Engineering
    G. Vlăsceanu, Cătălina Ionela Zamfir, C. Baltă, H. Herman, Alina Ciceu, Maria Alexandra Duma, Mariana Ioniță, R. Popescu, A. Hermenean
    Advanced Healthcare Materials, 2025
    This study presents the development of nanocomposite hydrogels that integrate functionalized reduced graphene oxide (rGO) derivatives carboxylated (CBX) and aminated (AMN) in combination with gellan gum, gelatin, and cellulose nanofibrils (CNFs) to enhance osteogenesis for bone tissue engineering. Their synthesis involves ultrasound exfoliation, genipin crosslinking, and freeze-drying. Micro-computed tomography (µCT) reveals highly porous, interconnected architectures facilitating nutrient diffusion and cell infiltration. CBX/AMN scaffolds exhibit superior hydration capacity and a biphasic degradation profile. Spectroscopically, enhanced interfacial interactions were confirmed, contributing to the overall structural stability of the hydrogels. In vitro, all scaffolds are cytocompatible, sustain cell viability, and promote osteogenic differentiation consistent with adaptive cellmaterial interactions. Subcutaneous implantation in mice confirms scaffold biocompatibility, showing no signs of inflammation or foreign body response. Histological and immunofluorescence analyses reveal osteogenic potential, with enhanced mineralization and elevated expression of osteopontin and osteocalcin. µCT imaging of explants quantifies ectopic mineralization, spatial deposition patterns, and bone mineral density, correlating scaffold architecture and composition with osteogenic performance. These findings suggest that the synergistic integration of functionalized rGO, CNFs, and biopolymers results in scaffolds with enhanced structural and biological properties, highlighting their potential for design optimization and clinical translation in bone regenerative medicine.
  • Processing and characterization of Ca3ZrSi2O9 ceramics doped with Ag+ ions for bone tissue engineering applications
    Ştefania Caramarin, Cornelia Ilie, Roxana-Cristina Popescu, George-Mihail Vlăsceanu, Roxana-Doina Truşcă, Ovidiu-Cristian Oprea, Cezar-Daniel Badea, Georgeta Voicu
    Journal of Alloys and Compounds, 2025
    This study presents the sol-gel synthesis, structural characterization and biological evaluation of silver-doped baghdadite (Ca 3 ZrSi 2 O 9 ) ceramics intended for bone tissue engineering applications. The proposed combination was selected to integrate the excellent bioactivity and mechanical stability of baghdadite with the well-known antimicrobial properties of silver ions, aiming to develop a multifunctional bioceramic suitable for osteointegration and infection prevention. Baghdadite powders were synthesized with varying Ag + contents (0, 2, 4 and 6 mol%) and thermally treated at 1350°C to obtain dense ceramic bodies. Structural analyses confirmed the successful incorporation of Ag + into the monoclinic baghdadite lattice without formation of secondary phases. SEM investigations revealed that silver doping enhanced microstructural densification, leading to increased crystallinity and reduced porosity. These structural improvements were reflected in the mechanical performance, with Ag6 achieving the highest compressive strength (∼52 MPa) and lowest porosity (∼34 %). In vitro assays using osteoblast-like cells demonstrated excellent cytocompatibility for all compositions, with Ag4 showing the highest cell viability (120 %) and no signs of morphological alteration. Although Ag⁺ doping did not accelerate mineralization, all Ag-containing samples exhibited significant antibacterial activity against S. aureus , E. coli , and C. Albicans. Overall, silver doping improved both the structural integrity and biological performance of baghdadite, confirming its potential as a multifunctional material for bone regeneration. • The sol-gel synthesis and characterization of Ag + -doped baghdadite ceramics (concentrations of Ag + - 2, 4 and 6 mol%). • The baghdadite ceramics have adequate strength and porosity and good biological properties (e.g. antibacterial properties). • The Ag + -doped baghdadite emerges as a promising candidate for bone tissue engineering applications.
  • Nanostructured gelatin-gellan inks double reinforced with cellulose nanofibrils and graphene derivatives for 3D printing in bone regeneration applications
    Mihaela-Raluca Dobrisan, Alin-Georgian Toader, Elena Alina Chiticaru, George Mihail Vlasceanu, Roxana-Cristina Popescu, Adrian-Ionuț Nicoara, Alice Ionela Podaru, Gabriela Toader, Traian Rotariu, Mariana Ionita
    Materials Today Advances, 2025
    Although 3D printing has become a prominent technique for fabricating scaffolds for bone tissue engineering (BTE), the development of inks capable of producing constructs with high biocompatibility, mineralization capabilities, and adequate mechanical properties remains a significant challenge. This study investigates the fabrication of scaffolds using 3D printing inks based on gelatin and gellan gum, reinforced with cellulose nanofibrils (GC), and two different functionalized graphene-based materials, i.e., carboxylated graphene oxide (GC-CBX), aminated reduced graphene oxide (GC-AMN), or both derivatives (GC-CBX/AMN). Through a dual cross-linking strategy, the 3D constructs demonstrated overall improved performance, with GC-CBX/AMN scaffolds exhibiting the best printing fidelity, optimal porosity, proper degradation rate and swelling kinetics, and the highest tensile strength. Finally, these samples exhibited excellent biocompatibility and the highest mineralization capacity. These results offer novel insights into the development of functional formulations for bone regeneration and provide a new strategy for advancing scaffold ink fabrication for BTE.
  • Suitability of Mg-Nd and Mg-Zn Alloys to Obtain Biodegradable Structures for Bone Defects
    Veronica Manescu (Paltanea), Aurora Antoniac, Maria Cristina Moraru, Iulian Antoniac, Cosmin Mihai Cotrut, Sebastian Gradinaru, Alexandra Iulia Dreanca, Bogdan Sevastre, Romelia Pop, Flaviu Alexandru Tabaran, George Mihail Vlasceanu, Mariana Ionita, Marius Manole
    Journal of Functional Biomaterials, 2025
    Mg-based alloys are one of the most promising materials used in regenerative medicine for bone tissue engineering. Considering the increasing prevalence of a continuously aging population, as well as the high incidence of accidents and bone cancers, it is crucial to explore biomaterials that can serve as bone substitutes. After carefully analyzing the literature in the introduction section, we proposed two Mg-based alloys as suitable for obtaining biodegradable structures for bone defect treatment. To achieve trustworthy results, the alloys’ microstructure was investigated using microscopic techniques coupled with energy-dispersive spectroscopy and X-ray diffraction. The obtained results were comparable with those described in references on similar Mg alloys. Then, the mechanical compression properties were highlighted, and the in vitro corrosion behavior proved that Mg-Zn exhibited a reduced corrosion rate compared to the Mg-Nd alloy, as tested using electrochemical methods. However, the in vivo tests showed good biocompatibility for both magnesium alloys. In conclusion, both alloys are suitable for use as potential bone substitute applications, but it must be taken into consideration that Mg-Zn alloys present lower biodegradation and mechanical properties. For future investigations, we aim to develop bone substitutes made from these materials, specifically designed for small bone defect treatment and with patient-adapted geometry. Due to the differences mentioned above, various designs will be tested.
  • Correction: Cellulose Nanofiber-Based Hydrogels Embedding 5-FU Promote Pyroptosis Activation in Breast Cancer Cells and Support Human Adipose-Derived Stem Cell Proliferation, Opening New Perspectives for Breast Tissue Engineering (Pharmaceutics, (2021), 13, 8, (1189), 10.3390/pharmaceutics13081189)
    Liliana-Roxana Balahura, Sorina Dinescu, Mihaela Balaș, Alexandra Cernencu, Adriana Lungu, George Mihail Vlasceanu, Horia Iovu, Marieta Costache
    Pharmaceutics, 2025
    In the original publication [...]
  • Correction: Comprehensive Appraisal of Graphene–Oxide Ratio in Porous Biopolymer Hybrids Targeting Bone-Tissue Regeneration (Nanomaterials, (2020), 10, 8, (1444), 10.3390/nano10081444)
    George Mihail Vlasceanu, Aida Șelaru, Sorina Dinescu, Cornel Balta, Hildegard Herman, Sami Gharbia, Anca Hermenean, Mariana Ionita, Marieta Costache
    Nanomaterials, 2025
    In the original publication [...]
  • Advanced Nanobiocomposite Hydrogels Incorporating Organofunctionalized LDH for Soft Tissue Engineering Applications
    Ionut-Cristian Radu, Eugenia Tanasa, Sorina Dinescu, George Vlasceanu, Catalin Zaharia
    Polymers, 2025
    Nanocomposite hydrogels are gaining significant attention for biomedical applications in soft tissue engineering due to the increasing demand for highly flexible and durable soft polymer materials. This research paper focused on investigating and optimizing a procedure for the development of novel nanocomposite hydrogels based on poly(2-hydroxyethyl methacrylate)-co-(2-acrylamido-2-methylpropane sulfonic acid) (HEMA/AMPSA) copolymers. These hydrogels were synthesized through a grafting-through process, where the polymer network was formed using a modified clay crosslinker. The layered double hydroxide (LDH) clay modified with 3-(trimethoxysilyl)propyl methacrylate (ATPM) was synthesized using a novel recipe through a two-step procedure. The nanocomposite hydrogel compositions were optimized to achieve soft hydrogels with high flexibility. The developed materials were analyzed for their mechanical and morphological properties using tensile and compressive tests, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and micro-computed tomography (micro-CT). The swelling behavior, network density, and kinetic diffusion mechanism demonstrated the specific characteristics of the materials. The modified LDH-ATPM was further characterized using Thermogravimetry (TGA), FTIR-ATR and X-ray diffraction (XRD). Biological assessments on human adipose-derived stem cells (hASCs) were essential to evaluate the biocompatibility of the nanocomposite hydrogels and their potential for soft tissue applications.
  • Dual nanofiber and graphene reinforcement of 3D printed biomimetic supports for bone tissue repair
    Elena Cojocaru, Mădălina Oprea, George Mihail Vlăsceanu, Mădălina-Cristina Nicolae, Roxana-Cristina Popescu, Paul-Emil Mereuţă, Alin-Georgian Toader, Mariana Ioniţă
    Rsc Advances, 2024
    Replicating the intricate architecture of the extracellular matrix by designing anisotropic biomimetic scaffolds with dual reinforcement of graphene oxide and electrospun nanofibers.
  • Fabrication of k-Carrageenan/Alginate/Carboxymethyl Cellulose basedScaffolds via 3D Printing for Potential Biomedical Applications
    Cristina Stavarache, Adi Ghebaur, Andrada Serafim, George Mihail Vlăsceanu, Eugeniu Vasile, Sorina Alexandra Gârea, Horia Iovu
    Polymers, 2024
  • Three-Dimensional-Printed Sodium Alginate and k-Carrageenan-Based Scaffolds with Potential Biomedical Applications
    Cristina Stavarache, Sorina Alexandra Gȃrea, Andrada Serafim, Elena Olăreț, George Mihail Vlăsceanu, Maria Minodora Marin, Horia Iovu
    Polymers, 2024
  • Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions
    Mariana Ioniță, George Mihail Vlăsceanu, Alin Georgian Toader, Marius Manole
    Journal of Personalized Medicine, 2023
  • Human Bone-Marrow-Derived Stem-Cell-Seeded 3D Chitosan–Gelatin–Genipin Scaffolds Show Enhanced Extracellular Matrix Mineralization When Cultured under a Perfusion Flow in Osteogenic Medium
    Gabriele Boretti, Emanuele Giordano, Mariana Ionita, George Mihail Vlasceanu, Ólafur Eysteinn Sigurjónsson, Paolo Gargiulo, Joseph Lovecchio
    Materials, 2023
  • 3D double-reinforced graphene oxide - nanocellulose biomaterial inks for tissue engineered constructs
    Alexandra I. Cernencu, George M. Vlasceanu, Andrada Serafim, Gratiela Pircalabioru, Mariana Ionita
    Rsc Advances, 2023
  • Nanocellulose Sponges Containing Antibacterial Basil Extract
    Gabriela Mădălina Oprică, Denis Mihaela Panaitescu, Catalina Diana Usurelu, George Mihai Vlăsceanu, Paul Octavian Stanescu, Brandusa Elena Lixandru, Valentin Vasile, Augusta Raluca Gabor, Cristian-Andi Nicolae, Marius Ghiurea, Adriana Nicoleta Frone
    International Journal of Molecular Sciences, 2023
  • Double-Reinforced Fish Gelatin Composite Scaffolds for Osteochondral Substitutes
    Alin Georgian Toader, George Mihail Vlasceanu, Andrada Serafim, Adela Banciu, Mariana Ionita
    Materials, 2023
  • Nanoclay-reinforced alginate/salecan composite inks for 3D printing applications
    Raluca Ianchis, Maria Minodora Marin, Rebeca Leu Alexa, Ioana Catalina Gifu, Elvira Alexandrescu, Gratiela Gradisteanu Pircalabioru, George Mihail Vlasceanu, George Mihail Teodorescu, Andrada Serafim, Silviu Preda, Cristina Lavinia Nistor, Cristian Petcu
    International Journal of Bioprinting, 2023
  • Nanofibrous scaffolds based on bacterial cellulose crosslinked with oxidized sucrose
    Denis Mihaela Panaitescu, Sergiu Stoian, Adriana Nicoleta Frone, George Mihai Vlăsceanu, Dora Domnica Baciu, Augusta Raluca Gabor, Cristian Andi Nicolae, Valentin Radiţoiu, Elvira Alexandrescu, Angela Căşărică, Celina Damian, Paul Stanescu
    International Journal of Biological Macromolecules, 2022
  • 3D Printed Composite Scaffolds of GelMA and Hydroxyapatite Nanopowders Doped with Mg/Zn Ions to Evaluate the Expression of Genes and Proteins of Osteogenic Markers
    Rebeca Leu Alexa, Andreia Cucuruz, Cristina-Daniela Ghițulică, Georgeta Voicu, Liliana-Roxana Stamat (Balahura), Sorina Dinescu, George Mihail Vlasceanu, Horia Iovu, Andrada Serafim, Raluca Ianchis, Lucian-Toma Ciocan, Marieta Costache
    Nanomaterials, 2022
  • Chitosan-Based Materials Featuring Multiscale Anisotropy for Wider Tissue Engineering Applications
    George Mihail Vlăsceanu, Mariana Ioniță, Corina Cristiana Popescu, Elena Diana Giol, Irina Ionescu, Andrei-Mihai Dumitrașcu, Mădălina Floarea, Iulian Boerasu, Mădălina Ioana Necolau, Elena Olăreț, Jana Ghițman, Horia Iovu
    International Journal of Molecular Sciences, 2022
  • 3D Printable Composite Biomaterials Based on GelMA and Hydroxyapatite Powders Doped with Cerium Ions for Bone Tissue Regeneration
    Rebeca Leu Alexa, Andreia Cucuruz, Cristina-Daniela Ghițulică, Georgeta Voicu, Liliana-Roxana Stamat (Balahura), Sorina Dinescu, George Mihail Vlasceanu, Cristina Stavarache, Raluca Ianchis, Horia Iovu, Marieta Costache
    International Journal of Molecular Sciences, 2022
  • Layered clay–graphene oxide nanohybrids for the reinforcement and fire-retardant properties of polyurea matrix
    Mădălina Ioana Necolau, Celina Maria Damian, Radu Claudiu Fierăscu, Anita-Laura Chiriac, George Mihail Vlăsceanu, Eugeniu Vasile, Horia Iovu
    Polymers, 2022
  • Graphene–oxide porous biopolymer hybrids enhance in vitro osteogenic differentiation and promote ectopic osteogenesis in vivo
    Aida Șelaru, Hildegard Herman, George Mihail Vlăsceanu, Sorina Dinescu, Sami Gharbia, Cornel Baltă, Marcel Roșu, Ciprian V. Mihali, Mariana Ioniță, Andrada Serafim, Horia Iovu, Anca Hermenean, Marieta Costache
    International Journal of Molecular Sciences, 2022
  • 3D printing of alginate-natural clay hydrogel-based nanocomposites
    Rebeca Leu Alexa, Raluca Ianchis, Diana Savu, Mihaela Temelie, Bogdan Trica, Andrada Serafim, George Mihail Vlasceanu, Elvira Alexandrescu, Silviu Preda, Horia Iovu
    Gels, 2021
  • Cellulose nanofiber-based hydrogels embedding 5-FU promote pyroptosis activation in breast cancer cells and support human adipose-derived stem cell proliferation, opening new perspectives for breast tissue engineering
    Liliana-Roxana Balahura, Sorina Dinescu, Mihaela Balaș, Alexandra Cernencu, Adriana Lungu, George Mihail Vlăsceanu, Horia Iovu, Marieta Costache
    Pharmaceutics, 2021
  • 5-aminosalicylic acid loaded chitosan-carrageenan hydrogel beads with potential application for the treatment of inflammatory bowel disease
    Cristina Elena Stavarache, Adi Ghebaur, Sorina Dinescu, Iuliana Samoilă, Eugeniu Vasile, George Mihail Vlasceanu, Horia Iovu, Sorina Alexandra Gârea
    Polymers, 2021
  • Assessment of naturally sourced mineral clays for the 3d printing of biopolymer-based nanocomposite inks
    Rebeca Leu Alexa, Horia Iovu, Bogdan Trica, Catalin Zaharia, Andrada Serafim, Elvira Alexandrescu, Ionut-Cristian Radu, George Vlasceanu, Silviu Preda, Claudia Mihaela Ninciuleanu, Raluca Ianchis
    Nanomaterials, 2021
  • 3D POSS cages decorated 2D graphenic sheets: A versatile platform for silicon-carbonaceous nano-additives design
    A. Lungu, A.I. Cernencu, G.M. Vlasceanu, N.M. Florea, M. Ionita, H. Iovu
    Composites Part B Engineering, 2021
  • The effect of crosslinking agents on the properties of type II collagen biomaterials
    Maria-Minodora Marin, Madalina Georgiana Albu Kaya, George Mihail Vlasceanu, Jana Ghitman, Ionut Cristian Radu, Horia Iovu
    Materiale Plastice, 2021
  • Physico-chemical enhancements of natural biopolymer matrices by reinforcing with complex carbonaceous-oxidic fillers
    UPB Scientific Bulletin Series B Chemistry and Materials Science, 2021
  • Comprehensive appraisal of graphene–oxide ratio in porous biopolymer hybrids targeting bone-tissue regeneration
    George Mihail Vlasceanu, Aida Șelaru, Sorina Dinescu, Cornel Balta, Hildegard Herman, Sami Gharbia, Anca Hermenean, Mariana Ionita, Marieta Costache
    Nanomaterials, 2020
  • Graphene oxide reinforcing genipin crosslinked chitosan-gelatin blend films
    George Mihail Vlasceanu, Livia Elena Crica, Andreea Madalina Pandele, Mariana Ionita
    Coatings, 2020
  • Predicting the drug loading efficiency into hybrid nanocarriers based on PLGA-vegetable oil using molecular dynamic simulation approach and Flory-Huggins theory
    Jana Ghitman, Raluca Stan, George Vlasceanu, Eugeniu Vasile, Horia Iovu
    Journal of Drug Delivery Science and Technology, 2019
  • Versatile biomaterial platform enriched with graphene oxide and carbon nanotubes for multiple tissue engineering applications
    Simona-Rebeca Ignat, Andreea Daniela Lazăr, Aida Şelaru, Iuliana Samoilă, George Mihail Vlăsceanu, Mariana Ioniţă, Eugen Radu, Sorina Dinescu, Marieta Costache
    International Journal of Molecular Sciences, 2019
  • Graphene inks for the 3D printing of cell culture scaffolds and related molecular arrays
    George Mihail Vlăsceanu, Horia Iovu, Mariana Ioniţă
    Composites Part B Engineering, 2019
  • Optical graphene-based biosensor for nucleic acid detection; influence of graphene functionalization and ionic strength
    Diana F. Becheru, George M. Vlăsceanu, Adela Banciu, Eugeniu Vasile, Mariana Ioniţă, Jorge S. Burns
    International Journal of Molecular Sciences, 2018
  • Versatile graphene biosensors for enhancing human cell therapy
    George M. Vlăsceanu, Roxana-Maria Amărandi, Mariana Ioniță, Teddy Tite, Horia Iovu, Luisa Pilan, Jorge S. Burns
    Biosensors and Bioelectronics, 2018
  • Advantages of Graphene Biosensors for Human Stem Cell Therapy Potency Assays
    Roxana-Maria Amărandi, Diana F. Becheru, George M. Vlăsceanu, Mariana Ioniță, Jorge S. Burns
    Biomed Research International, 2018
  • Graphene and functionalized graphene: Extraordinary prospects for nanobiocomposite materials
    Mariana Ioniţă, George Mihail Vlăsceanu, Aiza Andreea Watzlawek, Stefan Ioan Voicu, Jorge S. Burns, Horia Iovu
    Composites Part B Engineering, 2017
  • Nanostructures for cancer therapy: From targeting to selective toxicology
    George M. Vlasceanu, Lamaru Victor, Hodorogea Maricica, Tudor Raluca, Ologeanu Vlad, Irina Gheorghe, Alexandra Bolocan, Alexandru M. Grumezescu, Alina M. Holban
    Nanostructures for Cancer Therapy, 2017
  • Quantum dots for bioimaging and therapeutic applications
    George Vlasceanu, Alexandru Mihai Grumezescu, Irina Gheorghe, Mariana C. Chifiriuc, Alina M. Holban
    Nanostructures for Novel Therapy Synthesis Characterization and Applications, 2017
  • Alternative strategies to reduce the incidence of severe infections
    G.M. Vlăsceanu, A.M. Holban, A.M. Grumezescu
    Biofilms and Implantable Medical Devices Infection and Control, 2017
  • Properties of biofilms developed on medical devices
    R.A. Puiu, G. Dolete, A.-M. Ene, B. Nicoară, G.M. Vlăsceanu, A.M. Holban, A.M. Grumezescu, A. Bolocan
    Biofilms and Implantable Medical Devices Infection and Control, 2017
  • Nanostructurated composites based on biodegradable polymers and silver nanoparticles
    Oana Fufă, Oana Fuf?, George Mihail Vlăsceanu, Georgiana Dolete, Daniela Cabuzu, Rebecca Alexandra Puiu, Andreea Cîrjă, Bogdan Nicoară, Alexandru Mihai Grumezescu
    Handbook of Composites from Renewable Materials, 2017
  • Understanding dental implants
    Georgiana Dolete, Cristina Florina Ilie, Irina Florentina Nicoară, George Mihail Vlăsceanu, Alexandru Mihai Grumezescu
    Nanobiomaterials in Dentistry Applications of Nanobiomaterials, 2016
  • Silver nanoparticles in cancer therapy
    George Mihail Vlăsceanu, Ştefania Marin, Roxana Elena Ţiplea, Ioana Raluca Bucur, Mădălina Lemnaru, Maria Minodora Marin, Alexandru Mihai Grumezescu, Ecaterina Andronescu
    Nanobiomaterials in Cancer Therapy Applications of Nanobiomaterials, 2016
  • Applications and toxicity of silver nanoparticles: A recent review
    Stefania Marin, George Vlasceanu, Roxana Tiplea, Ioana Bucur, Madalina Lemnaru, Maria Marin, Alexandru Grumezescu
    Current Topics in Medicinal Chemistry, 2015

RECENT SCHOLAR PUBLICATIONS

  • 3D printing of multicomponent polymeric inks enables hierarchical hybrid architectures for bone tissue regeneration
    E Cojocaru, EA Chiticaru, GM Vlăsceanu, MC Nicolae, RC Popescu, ...
    Materials Today Advances 29, 100683 , 2026
    2026
  • Formulation and Characterization of Hydrogel Based on Pectin, Collagen, Alginate and Myrtus communis Essential Oil for Applications in Skin Regeneration
    MM Marin, JE Iancu, PA Vlaicu, DA Kaya, MGA Kaya, RR Constantinescu, ...
    Applied Sciences 16 (1), 186 , 2025
    2025
  • Nanostructured gelatin-gellan inks double reinforced with cellulose nanofibrils and graphene derivatives for 3D printing in bone regeneration applications
    MR Dobrisan, AG Toader, EA Chiticaru, GM Vlasceanu, RC Popescu, ...
    Materials Today Advances 28, 100621 , 2025
    2025
    Citations: 3
  • Functionalized Reduced Graphene Oxide‐Based Nanocomposite Hydrogels for Enhanced Osteogenesis in Bone Tissue Engineering
    GM Vlăsceanu, CI Zamfir, C Baltă, H Herman, A Ciceu, ...
    Advanced Healthcare Materials 14 (31), e01941 , 2025
    2025
    Citations: 4
  • Processing and characterization of Ca3ZrSi2O9 ceramics doped with Ag+ ions for bone tissue engineering applications
    S Caramarin, C Ilie, RC Popescu, GM Vlăsceanu, RD Truşcă, OC Oprea, ...
    Journal of Alloys and Compounds, 185099 , 2025
    2025
    Citations: 2
  • Suitability of Mg-Nd and Mg-Zn Alloys to Obtain Biodegradable Structures for Bone Defects
    V Manescu, A Antoniac, MC Moraru, I Antoniac, CM Cotrut, S Gradinaru, ...
    Journal of Functional Biomaterials 16 (11), 423 , 2025
    2025
    Citations: 2
  • Correction: Balahura et al. Cellulose Nanofiber-Based Hydrogels Embedding 5-FU Promote Pyroptosis Activation in Breast Cancer Cells and Support Human Adipose-Derived Stem Cell …
    LR Balahura, S Dinescu, M Balaș, A Cernencu, A Lungu, GM Vlasceanu, ...
    Pharmaceutics 17 (9), 1122 , 2025
    2025
  • Comprehensive Appraisal of Graphene-Oxide Ratio in Porous Biopolymer Hybrids Targeting Bone-Tissue Regeneration (vol 10, 1444, 2020)
    GM Vlasceanu, A Selaru, S Dinescu, C Balta, H Herman, S Gharbia, ...
    NANOMATERIALS 15 (15) , 2025
    2025
  • Correction: Vlasceanu et al. Comprehensive Appraisal of Graphene–Oxide Ratio in Porous Biopolymer Hybrids Targeting Bone-Tissue Regeneration. Nanomaterials 2020, 10, 1444
    GM Vlasceanu, A Șelaru, S Dinescu, C Balta, H Herman, S Gharbia, ...
    Nanomaterials 15 (15), 1207 , 2025
    2025
  • Advanced Nanobiocomposite Hydrogels Incorporating Organofunctionalized LDH for Soft Tissue Engineering Applications
    IC Radu, E Tanasa, S Dinescu, G Vlasceanu, C Zaharia
    Polymers 17 (4), 536 , 2025
    2025
    Citations: 1
  • MORPHOLOGICAL STUDIES ON CERAMIC SCAFFOLDS BASED ON PRISTINE AND ZINC-DOPED MERWINITE APPLIED TO TISSUE ENGINEERING
    FG Ioniță, GM Vlăsceanu, C Busuioc
    Book of Abstracts, 87 , 2024
    2024
  • Fabrication of k-carrageenan/alginate/carboxymethyl cellulose basedscaffolds via 3D printing for potential biomedical applications
    C Stavarache, A Ghebaur, A Serafim, GM Vlăsceanu, E Vasile, SA Gârea, ...
    Polymers 16 (11), 1592 , 2024
    2024
    Citations: 18
  • Three-dimensional-printed sodium alginate and k-carrageenan-based scaffolds with potential biomedical applications
    C Stavarache, SA Gȃrea, A Serafim, E Olăreț, GM Vlăsceanu, MM Marin, ...
    Polymers 16 (3), 305 , 2024
    2024
    Citations: 18
  • Dual nanofiber and graphene reinforcement of 3D printed biomimetic supports for bone tissue repair
    E Cojocaru, M Oprea, GM Vlăsceanu, MC Nicolae, RC Popescu, ...
    RSC advances 14 (44), 32517-32532 , 2024
    2024
    Citations: 10
  • Advances in therapeutic contact lenses for the management of different ocular conditions
    M Ioniță, GM Vlăsceanu, AG Toader, M Manole
    Journal of personalized medicine 13 (11), 1571 , 2023
    2023
    Citations: 26
  • Advances in Therapeutic Contact Lenses for Different Ocular Condition Management
    M Ioniță, GM Vlăsceanu, GA Toader, M Manole
    Preprints , 2023
    2023
  • Human bone-marrow-derived stem-cell-seeded 3D chitosan–gelatin–genipin scaffolds show enhanced extracellular matrix mineralization when cultured under a perfusion flow in …
    G Boretti, E Giordano, M Ionita, GM Vlasceanu, ÓE Sigurjónsson, ...
    Materials 16 (17), 5898 , 2023
    2023
    Citations: 7
  • Nanoclay-reinforced alginate/salecan composite inks for 3D printing applications
    R Ianchis, MM Marin, RL Alexa, IC Gifu, E Alexandrescu, GG Pircalabioru, ...
    International Journal of Bioprinting 10 (1), 0967 , 2023
    2023
    Citations: 7
  • Double-reinforced fish gelatin composite scaffolds for osteochondral substitutes
    AG Toader, GM Vlasceanu, A Serafim, A Banciu, M Ionita
    Materials 16 (5), 1815 , 2023
    2023
    Citations: 7
  • 3D double-reinforced graphene oxide–nanocellulose biomaterial inks for tissue engineered constructs
    AI Cernencu, GM Vlasceanu, A Serafim, G Pircalabioru, M Ionita
    RSC advances 13 (34), 24053-24063 , 2023
    2023
    Citations: 21

MOST CITED SCHOLAR PUBLICATIONS

  • Applications and toxicity of silver nanoparticles: a recent review
    S Marin, G Mihail Vlasceanu, R Elena Tiplea, I Raluca Bucur, M Lemnaru, ...
    Current topics in medicinal chemistry 15 (16), 1596-1604 , 2015
    2015
    Citations: 318
  • Graphene and functionalized graphene: Extraordinary prospects for nanobiocomposite materials
    M Ioniţă, GM Vlăsceanu, AA Watzlawek, SI Voicu, JS Burns, H Iovu
    Composites Part B: Engineering 121, 34-57 , 2017
    2017
    Citations: 215
  • Graphene inks for the 3D printing of cell culture scaffolds and related molecular arrays
    GM Vlăsceanu, H Iovu, M Ioniţă
    Composites Part B: Engineering 162, 712-723 , 2019
    2019
    Citations: 70
  • 3D printable composite biomaterials based on GelMA and hydroxyapatite powders doped with cerium ions for bone tissue regeneration
    R Leu Alexa, A Cucuruz, CD Ghițulică, G Voicu, LR Stamat, S Dinescu, ...
    International journal of molecular sciences 23 (3), 1841 , 2022
    2022
    Citations: 61
  • Versatile biomaterial platform enriched with graphene oxide and carbon nanotubes for multiple tissue engineering applications
    SR Ignat, AD Lazăr, A Şelaru, I Samoilă, GM Vlăsceanu, M Ioniţă, E Radu, ...
    International journal of molecular sciences 20 (16), 3868 , 2019
    2019
    Citations: 46
  • Silver nanoparticles in cancer therapy
    GM Vlăsceanu, Ş Marin, RE Ţiplea, IR Bucur, M Lemnaru, MM Marin, ...
    Nanobiomaterials in Cancer Therapy, 29-56 , 2016
    2016
    Citations: 46
  • Cellulose nanofiber-based hydrogels embedding 5-FU promote pyroptosis activation in breast cancer cells and support human adipose-derived stem cell proliferation, opening new …
    LR Balahura, S Dinescu, M Balaș, A Cernencu, A Lungu, GM Vlăsceanu, ...
    Pharmaceutics 13 (8), 1189 , 2021
    2021
    Citations: 45
  • Graphene oxide reinforcing genipin crosslinked chitosan-gelatin blend films
    GM Vlasceanu, LE Crica, AM Pandele, M Ionita
    Coatings 10 (2), 189 , 2020
    2020
    Citations: 45
  • 5-Aminosalicylic acid loaded chitosan-carrageenan hydrogel beads with potential application for the treatment of inflammatory bowel disease
    CE Stavarache, A Ghebaur, S Dinescu, I Samoilă, E Vasile, ...
    Polymers 13 (15), 2463 , 2021
    2021
    Citations: 39
  • Assessment of naturally sourced mineral clays for the 3D printing of biopolymer-based nanocomposite inks
    RL Alexa, H Iovu, B Trica, C Zaharia, A Serafim, E Alexandrescu, IC Radu, ...
    Nanomaterials 11 (3), 703 , 2021
    2021
    Citations: 38
  • Versatile graphene biosensors for enhancing human cell therapy
    GM Vlăsceanu, RM Amărandi, M Ioniță, T Tite, H Iovu, L Pilan, JS Burns
    Biosensors and Bioelectronics 117, 283-302 , 2018
    2018
    Citations: 37
  • Nanostructures for cancer therapy
    AM Grumezescu, A Ficai
    Elsevier , 2017
    2017
    Citations: 36
  • 3D printing of alginate-natural clay hydrogel-based nanocomposites
    R Leu Alexa, R Ianchis, D Savu, M Temelie, B Trica, A Serafim, ...
    Gels 7 (4), 211 , 2021
    2021
    Citations: 34
  • Comprehensive appraisal of graphene–oxide ratio in porous biopolymer hybrids targeting bone-tissue regeneration
    GM Vlasceanu, A Șelaru, S Dinescu, C Balta, H Herman, S Gharbia, ...
    Nanomaterials 10 (8), 1444 , 2020
    2020
    Citations: 29
  • Graphene–oxide porous biopolymer hybrids enhance in vitro osteogenic differentiation and promote ectopic osteogenesis in vivo
    A Șelaru, H Herman, GM Vlăsceanu, S Dinescu, S Gharbia, C Baltă, ...
    International Journal of Molecular Sciences 23 (1), 491 , 2022
    2022
    Citations: 28
  • 3D POSS cages decorated 2D graphenic sheets: A versatile platform for silicon-carbonaceous nano-additives design
    A Lungu, AI Cernencu, GM Vlasceanu, NM Florea, M Ionita, H Iovu
    Composites Part B: Engineering 207, 108578 , 2021
    2021
    Citations: 28
  • Optical graphene-based biosensor for nucleic acid detection; influence of graphene functionalization and ionic strength
    DF Becheru, GM Vlăsceanu, A Banciu, E Vasile, M Ioniţă, JS Burns
    International Journal of Molecular Sciences 19 (10), 3230 , 2018
    2018
    Citations: 27
  • Advances in therapeutic contact lenses for the management of different ocular conditions
    M Ioniță, GM Vlăsceanu, AG Toader, M Manole
    Journal of personalized medicine 13 (11), 1571 , 2023
    2023
    Citations: 26
  • 3D printed composite scaffolds of GelMA and hydroxyapatite nanopowders doped with Mg/Zn ions to evaluate the expression of genes and proteins of osteogenic markers
    R Leu Alexa, A Cucuruz, CD Ghițulică, G Voicu, LR Stamat, S Dinescu, ...
    Nanomaterials 12 (19), 3420 , 2022
    2022
    Citations: 24
  • Predicting the drug loading efficiency into hybrid nanocarriers based on PLGA-vegetable oil using molecular dynamic simulation approach and Flory-Huggins theory
    J Ghitman, R Stan, G Vlasceanu, E Vasile, H Iovu
    Journal of Drug Delivery Science and Technology 53, 101203 , 2019
    2019
    Citations: 24