Frederic Sampedro

Scopus Publications

The profiling of extracellular vesicle subtypes in Huntington’s disease brains identifies Alix as a novel marker of neuropathology
Rocío Pérez-González, Anna Vázquez-Oliver, Nil Salvat-Rovira, Saül Martínez-Horta, Elisa Rivas-Asensio, Eva Borràs, Samanta Ortuño-Miquel, María Sánchez-Carcelén, Marta Garcia-Forn, Frederic Sampedro, Jesús Pérez-Pérez, Eduard Sabidó, Esther Pérez-Navarro, Jaime Kulisevsky
Acta Neuropathologica Communications, 2026
Background Huntington’s disease (HD) is the most frequent autosomal dominant neurodegenerative disorder, which is caused by a CAG repeat expansion in the HTT gene. Despite its well-defined genetic origin, there is currently no cure, and reliable biomarkers for disease progression and pathophysiology remain limited. Mutant huntingtin protein accumulates in endosomal compartments, disrupting endosomal trafficking and potentially affecting the biogenesis, release, and cargo of exosomes–extracellular vesicles (EVs) derived from the endosomal pathway. However, the role of exosomes in HD pathogenesis and their potential as biomarkers has been underexplored. In this work, we investigated whether the levels and content of small EV subpopulations, including exosomes, are altered in the brains of HD patients. Methods We analyzed two distinct subpopulations of small EVs from the striatum and cortex of postmortem HD brains at early and advanced neuropathological stages, as well as from age-matched controls. EVs were isolated by differential ultracentrifugation and high-resolution iodixanol density gradient centrifugation, and analyzed by Western blotting, electron microscopy, NTA, and proteomics using mass spectrometry. EV secretion was also analyzed in primary fibroblasts derived from HD patients and healthy controls. Results Mass spectrometry data revealed HD-associated alterations in EV protein content, particularly proteins related to the endosomal system. Our data also indicate that the level of ectosomes increased in the HD cortex, whereas exosomes were reduced in the HD striatum compared to controls. In terms of EV content, EVs from HD brains showed increased levels of Annexin A2 and decreased levels of Alix, a key component of the endosomal sorting complex required for transport (ESCRT). Alix depletion in EVs mirrored a progressive reduction of Alix in brain tissue, correlating with disease severity based on Vonsattel staging. In vitro, HD fibroblasts secreted EVs with reduced Alix content, despite no significant difference in cellular Alix levels compared to controls. Conclusions These findings highlight disease-specific changes in EV populations and cargo in HD, and identify Alix as a potential neuropathological marker. This study advances our understanding of the role of brain-derived EVs in HD and underscores their potential utility in biomarker discovery.
Neural and biomarker correlates of the Parkinson's Disease–Cognitive Rating Scale in Huntington's disease
Saul Martinez-Horta, Arnau Puig-Davi, Frederic Sampedro, Jesús Pérez-Pérez, Carla Franch-Martí, Gonzalo Olmedo-Saura, Elisa Rivas-Asensio, Anna Vazquez-Oliver, Laura Pérez-Carasol, Andrea Horta-Barba, Javier Pagonabarraga, Jaime Kulisevsky
Neuroimage Reports, 2026
Background: Cognitive decline is a core feature of Huntington's disease (HD), often preceding motor symptoms and progressing with disease severity. While several neuropsychological tests track cognitive changes, few studies have examined the biological correlates of brief screening tools adapted for HD. Objectives: This study investigates the neuroanatomical and fluid biomarker correlates of performance on the Parkinson's Disease-Cognitive Rating Scale (PD-CRS), aiming to validate it as a clinically and biologically grounded tool for cognitive assessment in HD. Methods: Fifty-two symptomatic gene-expansion carriers (CAG >39) underwent cognitive (PD-CRS), motor (UHDRS), and behavioral (PBA) assessments. Plasma neurofilament light chain (NfL) levels were measured via Simoa as a marker of neurodegeneration. Voxel-based morphometry (VBM) was used to identify gray matter volume (GMV) correlates of PD-CRS scores. Linear regressions evaluated relationships among PD-CRS, GMV, and NfL, including subdomain-level and stage-stratified analyses based on HD-ISS classification. Results: = 0.519), particularly in later disease stages. Conclussions: The PD-CRS reflects biologically meaningful aspects of cognitive dysfunction in HD, with robust associations to structural and molecular disease markers. These findings support its use as a practical and sensitive tool for clinical and research applications.
Spontaneous speech and language measures as predictive biomarkers of clinically meaningful disease progression and neurodegeneration in Huntington’s disease
Arnau Puig-Davi, Carla Franch-Marti, Lara Caler-Gameiro, Jesus Perez-Perez, Gonzalo Olmedo-Saura, Jon Rodriguez-Antiguedad, Anna Vázquez-Oliver, Elisa Rivas-Asensio, Laura Perez-Carasol, Margarita Rubio-Romera, Yi Ji, Iñigo Ruiz-Barrio, Lidia Bojtos, Frederic Sampedro, Javier Pagonabarraga, Jaime Kulisevsky, Saul Martinez-Horta
Journal of Neural Transmission, 2026
Huntington’s disease (HD) is characterized by heterogeneous rates of clinical progression, complicating patient monitoring and clinical trial design. Although speech and language alterations are increasingly recognized as part of the HD cognitive phenotype, their value as short-term prognostic biomarkers of clinically meaningful disease progression and neurodegeneration remains unestablished. In this prospective 12-month longitudinal study, we investigated whether objectively quantified spontaneous speech and language measures predict short-term clinically meaningful progression and relate to biomarkers of neurodegeneration in HD. Eighty-six participants (42 manifest HD, 24 premanifest gene carriers, and 20 healthy controls) underwent baseline spontaneous speech assessment, structural MRI, and plasma neurofilament light chain (NfL) quantification. Clinically meaningful worsening was defined using validated minimal clinically important difference thresholds in the composite Unified Huntington’s Disease Rating Scale (cUHDRS). Spontaneous speech and language measures progressively deteriorated across disease stages and were associated with reduced cortico-subcortical gray matter volume in distributed associative and integrative regions. In manifest HD, logistic regression analyses revealed that baseline language integrity independently predicted clinically meaningful worsening at 12 months (OR = 3.840, 95% CI = 1.46–13.33; AUC = 0.783). Combining speech-derived measures with plasma NfL improved discrimination accuracy of individuals with accelerated clinical progression (AUC = 0.807). Spontaneous speech represents an early, accessible and sensitive marker of neurodegeneration in HD. The combination of speech and language derived measures and plasma NfL enables accurate identification of individuals at risk of accelerated, clinically meaningful disease progression, supporting their potential utility as short-term prognostic biomarkers for clinical trials enrichment and stratification.
Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease
Arnau Puig‐Davi, Carla Franch‐Marti, Iñigo Ruiz‐Barrio, Frederic Sampedro, Jesus Perez‐Perez, Jordi A. Matias‐Guiu, Fernando Cuetos, Gonzalo Olmedo‐Saura, Laura Perez‐Carasol, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Javier Pagonabarraga, Jaime Kulisevsky, Saul Martinez‐Horta
Annals of Clinical and Translational Neurology, 2025
ObjectiveHuntington's disease (HD) speech/language disorders have typically been attributed to motor and executive impairment due to striatal dysfunction. In‐depth study of linguistic skills and the role of extrastriatal structures in HD is scarce. This study aimed to explore the profile of language compromise in HD and identify the structural neuroimaging correlates.MethodsLanguage and structural correlates were assessed using the Mini Linguistic State Examination (MLSE) in 81 participants (20 HD‐ISS 0‐1, 40 HD‐ISS 2‐3 and 21 controls). Clinical and global cognition measures were also obtained. Imaging data included computed gray matter volume (GMV) and cortical thickness (CTh) values extracted from a general linear model with the MLSE. Correlation analyses were performed with the language components of the MLSE. Multivariate regression analyses were used to explore the predictive ability of the language components on GMV and CTh loss.ResultsHD individuals showed impaired MLSE performance (84.5 ± 12.8), particularly in syntax, motor speech, and to a lesser extent, semantics and phonology. Significant associations were found between linguistic performance and the structural integrity of nodes within the temporo‐parietal, fronto‐parietal, and fronto‐striatal lexical‐semantic and syntactic networks. Correlation analyses linked motor speech and syntax with predominantly left fronto‐striatal GMV and CTh clusters, while semantics had a bilateral fronto‐parietal topography. Multivariate regression analyses showed language domains as independent contributing factors of GMV and CTh loss in classical language‐related regions.InterpretationLanguage impairment is an integral part of the HD cognitive phenotype, with severity associated with structural disintegration in extensive cortico‐subcortical territories involved in language production and processing.
A randomized clinical trial to evaluate the efficacy of cognitive rehabilitation and music therapy in mild cognitive impairment in Huntington’s disease
Andrea Moreu-Valls, Arnau Puig-Davi, Saul Martinez-Horta, Gabriel Kulisevsky, Frederic Sampedro, Jesus Perez-Perez, Andrea Horta-Barba, Gonzalo Olmedo-Saura, Javier Pagonabarraga, Jaime Kulisevsky
Journal of Neurology, 2025
Retinal Microperimetry as a Novel Tool for Early Detection of Subclinical Cognitive Dysfunction and Brain Damage in Type 1 Diabetes: A Pilot Study
Manel Mateu‐Salat, Nicole Stanton‐Yonge, Frederic Sampedro Santaló, José Ignacio Vela, Jesús Díaz Cascajosa, Eva Safont Pérez, Daniela Rego‐Lorca, Ana Chico
Endocrinology Diabetes and Metabolism, 2025
ContextRetinal microperimetry (MPR) is a non‐invasive method that measures retinal light sensitivity (RS) and gaze fixation stability (GFS). MPR has been described as a marker of cognitive impairment in people with Type 2 diabetes, but it has never been assessed in people with Type 1 diabetes (T1D). Our group described subclinical cognitive alterations, structural brain differences, and increased levels of light chain neurofilament (NfL) in people with T1D and impaired awareness of hypoglycaemia.ObjectiveTo measure RS and GFS using MPR in individuals with T1D and evaluate its correlation with neuropsychological assessment, plasma NfL levels and CGM‐derived glucometric parameters. Secondary objectives: to evaluate the possible differences of RS and GFS in people with T1D depending on hypoglycaemia awareness.Design, Setting and ParticipantsPilot observational study, people with T1D without clinical cognitive impairment, moderate–severe retinopathy or glaucoma. MPR was performed with MAIA3.ResultsA total of 30 subjects were studied: 40% women, age 58 ± 11 years; T1D duration 31 ± 9 years, mild retinopathy 33%. RS was 27.5 dB (26.1–28.3) and GFS(%) 97.6% (93.5%–99.5%). We found a correlation between RS and memory alteration tests (p = 0.016) and between GFS(%) and a composite of attention and executive neuropsychological tests (p = 0.025). An inverse correlation between GFS and time below range was found. No correlation was found with NfL.ConclusionThis first exploratory study in people with T1D supports the potential utility of MPR as a screening tool for subclinical neurocognitive alterations in this population.
Consolidation deficits in episodic memory define distinct clinical and neurodegenerative profiles in Huntington’s disease
Saul Martinez-Horta, Angela Quevedo-García, Arnau Puig-Davi, Frederic Sampedro, Javier Oltra-Cucarella, Jesús Pérez-Pérez, Carla Franch-Martí, Gonzalo Olmedo-Saura, Elisa Rivas-Asensio, Anna Vazquez-Oliver, Laura Pérez-Carasol, Andrea Horta-Barba, Javier Pagonabarraga, Jaime Kulisevsky
Neuroimage Clinical, 2025
BACKGROUND: Huntington's disease (HD) is primarily associated with executive dysfunction, but episodic memory impairment is also present. Traditionally, these memory deficits have been attributed to retrieval difficulties linked to fronto-striatal dysfunction, rather than to disruptions in encoding or consolidation processes. However, the specific nature and diversity of memory impairments in HD remain underexplored. OBJECTIVE: To characterize the profile of episodic memory impairment in HD, identify distinct cognitive phenotypes, and examine their clinical, neuroanatomical, and biomarker correlates. METHODS: We assessed episodic memory in HD patients and healthy controls using the Free and Cued Selective Reminding Test (FCSRT), complemented by Item-Specific Deficit Approach (ISDA) indices to quantify encoding, consolidation, and retrieval deficits. Structural MRI was used to identify gray matter volume correlates, and plasma neurofilament light chain (NfL) was measured as a marker of neuroaxonal injury. RESULTS: Compared to controls, HD patients showed marked impairments in free recall with preserved cued recall, suggesting predominant retrieval deficits. However, nearly one-third of patients exhibited global impairments across all FCSRT components, mainly driven by consolidation deficits consistent with medial temporal lobe dysfunction. This subgroup also showed worse cognitive and functional performance and significant atrophy in the hippocampus, entorhinal cortex, and parahippocampal gyrus. CONCLUSION: Episodic memory dysfunction in HD is heterogeneous and includes both retrieval-related and consolidation-driven profiles. These profiles reflect distinct neurodegenerative patterns, emphasizing the importance of cognitive subtyping for improving clinical characterization and biomarker development in HD.
Facial emotion recognition deficits are associated with hypomimia and related brain correlates in Parkinson’s disease
Jon Rodríguez-Antigüedad, Saül Martínez-Horta, Andrea Horta-Barba, Arnau Puig-Davi, Antonia Campolongo, Frederic Sampedro, Helena Bejr-Kasem, Juan Marín-Lahoz, Javier Pagonabarraga, Jaime Kulisevsky
Journal of Neural Transmission, 2024
Prediction of Cognitive Heterogeneity in Parkinson's Disease: A 4-Year Longitudinal Study Using Clinical, Neuroimaging, Biological and Electrophysiological Biomarkers
Arnau Puig‐Davi, Saul Martinez‐Horta, Laura Pérez‐Carasol, Andrea Horta‐Barba, Iñigo Ruiz‐Barrio, Ignacio Aracil‐Bolaños, Rocío Pérez‐González, Elisa Rivas‐Asensio, Frederic Sampedro, Antonia Campolongo, Javier Pagonabarraga, Jaime Kulisevsky
Annals of Neurology, 2024
ObjectiveCognitive impairment in Parkinson's disease (PD) can show a very heterogeneous trajectory among patients. Here, we explored the mechanisms involved in the expression and prediction of different cognitive phenotypes over 4 years.MethodsIn 2 independent cohorts (total n = 475), we performed a cluster analysis to identify trajectories of cognitive progression. Baseline and longitudinal level II neuropsychological assessments were conducted, and baseline structural magnetic resonance imaging, resting electroencephalogram and neurofilament light chain plasma quantification were carried out. Linear mixed‐effects models were used to study longitudinal changes. Risk of mild cognitive impairment and dementia were estimated using multivariable hazard regression. Spectral power density from the electroencephalogram at baseline and source localization were computed.ResultsTwo cognitive trajectories were identified. Cluster 1 presented stability (PD‐Stable) over time, whereas cluster 2 showed progressive cognitive decline (PD‐Progressors). The PD‐Progressors group showed an increased risk for evolving to PD mild cognitive impairment (HR 2.09; 95% CI 1.11–3.95) and a marked risk for dementia (HR 4.87; 95% CI 1.34–17.76), associated with progressive worsening in posterior‐cortical‐dependent cognitive processes. Both clusters showed equivalent clinical and sociodemographic characteristics, structural magnetic resonance imaging, and neurofilament light chain levels at baseline. Conversely, the PD‐Progressors group showed a fronto‐temporo‐occipital and parietal slow‐wave power density increase, that was in turn related to worsening at 2 and 4 years of follow‐up in different cognitive measures.InterpretationIn the absence of differences in baseline cognitive function and typical markers of neurodegeneration, the further development of an aggressive cognitive decline in PD is associated with increased slow‐wave power density and with a different profile of worsening in several posterior‐cortical‐dependent tasks. ANN NEUROL 2024
Skin Tau Quantification as a Novel Biomarker in Huntington's Disease
Iñigo Ruiz‐Barrio, Anna Vázquez‐Oliver, Arnau Puig‐Davi, Elisa Rivas‐Asensio, Jesus Perez‐Perez, Cristina Fernandez‐Vizuete, Andrea Horta‐Barba, Gonzalo Olmedo‐Saura, Nil Salvat‐Rovira, Frederic Sampedro, Elena Vacchi, Giorgia Melli, Javier Pagonabarraga, Jaime Kulisevsky, Saul Martinez‐Horta
Movement Disorders, 2024
BackgroundEmerging research implicates tau protein dysregulation in the pathophysiology of Huntington's disease.ObjectiveThis study investigated skin tau quantification as a potential biomarker for Huntington's disease and its correlation with disease burden outcomes.MethodsIn this cross‐sectional study, we measured skin tau levels using enzyme‐linked immunosorbent assay in 23 Huntington's disease mutations carriers and eight control subjects, examining group discrimination, correlations with genetic markers, clinical assessments, and neuroimaging data. Brain atrophy was quantified by both volumetric measurements from brain segmentation and a voxel‐based morphometry approach.ResultsOur findings showed elevated skin tau levels in manifest Huntington's disease compared with premanifest and healthy controls. These levels correlated with CAG repeat length, CAG‐Age‐Product score, composite Unified Huntington's Disease Rating Scale Total Motor Score, cognitive assessments, and disease‐related cortical and subcortical volumes, all independent of age and gender. Using skin tau levels in cluster analysis along with genetic and clinical measures led to improved subject stratification, providing enhanced distinction and validity of clusters.ConclusionsThis study not only confirms the feasibility of skin tau quantification in Huntington's disease but also establishes its potential as a biomarker for enhancing group classification and assessing disease severity across the Huntington's disease spectrum, opening new directions in biomarker research. © 2024 International Parkinson and Movement Disorder Society.
Cognitive phenotype and neurodegeneration associated with Tau in Huntington's disease
Saul Martinez‐Horta, Jesús Perez‐Perez, Rocío Perez‐Gonzalez, Frederic Sampedro, Andrea Horta‐Barba, Antonia Campolongo, Elisa Rivas‐Asensio, Arnau Puig‐Davi, Javier Pagonabarraga, Jaime Kulisevsky
Annals of Clinical and Translational Neurology, 2024
The success of assessing cortical microstructure through surface-based diffusion-weighted neuroimaging
Frederic Sampedro
Clinical Neurology and Neurosurgery, 2023
Divergent cognitive trajectories in early stage Huntington's disease: A 3-year longitudinal study
Saul Martínez‐Horta, Jesús Perez‐Perez, Javier Oltra‐Cucarella, Frederic Sampedro, Andrea Horta‐Barba, Arnau Puig‐Davi, Javier Pagonabarraga, Jaime Kulisevsky
European Journal of Neurology, 2023
Structural and metabolic brain correlates of arithmetic word-problem solving in Huntington's disease
Andrea Horta‐Barba, Saul Martinez‐Horta, Frederic Sampedro, Jesús Pérez‐Pérez, Javier Pagonabarraga, Jaime Kulisevsky
Journal of Neuroscience Research, 2023
Cortical macro and microstructural correlates of cognitive and neuropsychiatric symptoms in Parkinson's disease
Frederic Sampedro, Arnau Puig-Davi, Saul Martinez-Horta, Javier Pagonabarraga, Andrea Horta-Barba, Ignacio Aracil-Bolaños, Jaime Kulisevsky
Clinical Neurology and Neurosurgery, 2023
Editorial: Genotype–phenotype correlations in neurodegenerative diseases: From clinical features to neuroimaging signatures
Pilar M. Ferraro, Nicola Spotorno, Eoin Finegan, Frederic Sampedro, Francesca Caso
Frontiers in Neurology, 2022
Predicting Impulse Control Disorders in Parkinson Disease through Incentive Biomarkers
Juan Marín‐Lahoz, Saül Martinez‐Horta, Javier Pagonabarraga, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Helena Bejr‐kasem, Frederic Sampedro, Antonia Campolongo, Jaime Kulisevsky
Annals of Neurology, 2022
Plasma TDP-43 Reflects Cortical Neurodegeneration and Correlates with Neuropsychiatric Symptoms in Huntington’s Disease
Frederic Sampedro, Saul Martínez-Horta, Jesus Pérez-Pérez, Rocío Pérez-González, Andrea Horta-Barba, Antonia Campolongo, Cristina Izquierdo, Ignacio Aracil-Bolaños, Elisa Rivas, Arnau Puig-Davi, Javier Pagonabarraga, Beatriz Gómez-Ansón, Jaime Kulisevsky
Clinical Neuroradiology, 2022
Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease
Javier Pagonabarraga, Rocío Pérez-González, Helena Bejr-kasem, Juan Marín-Lahoz, Andrea Horta-Barba, Saul Martinez-Horta, Ignacio Aracil-Bolaños, Frederic Sampedro, Antonia Campolongo, Elisa Rivas, Arnau Puig-Davi, I. Ruiz-Barrios, Jesús Pérez-Pérez, Berta Pascual-Sedano, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2022
Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease
Frederic Sampedro, Saul Martínez‐Horta, Andrea Horta‐Barba, Michel J. Grothe, Miguel A. Labrador‐Espinosa, Silvia Jesús, Astrid Adarmes‐Gomez, Fatima Carrillo, Arnau Puig‐Davi, Florinda Roldan‐Lora, Miquel Aguilar‐Barbera, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots‐Foraster, Javier Ruiz‐Martínez, Francisco Carrillo‐Padilla, Mercedes Pueyo‐Morlans, Isabel Gonzalez‐Aramburu, Jon Infante‐Ceberio, Jorge Hernandez‐Vara, Oriol de Fabregues‐Boixar, Teresa de Deus Fonticoba, Asuncion Avila, Juan Carlos Martínez‐Castrillo, Helena Bejr‐Kasem, Antonia Campolongo, Berta Pascual‐Sedano, Pablo Martínez‐Martín, Diego Santos‐García, Pablo Mir, Pedro J. Garcia‐Ruiz, Jaime Kulisevsky, and
European Journal of Neurology, 2022
Brain metabolic changes in patients with disseminated malignant melanoma under immunotherapy
Marina Sizova, Valle Camacho, Frederic Sampedro, Aida Sabaté-Llobera, Safae Abouzian, Patricia Stefaneli, Joan Duch, Alejandro Fernández-León, Diego Alfonso López-Mora, Montserrat Estorch, Ignasi Carrió, Albert Flotats
Melanoma Research, 2022
The role of attentional control over interference in minor hallucinations in Parkinson's disease
Helena Bejr-kasem, Saül Martínez-Horta, Javier Pagonabarraga, Juan Marín-Lahoz, Andrea Horta-Barba, Frederic Sampedro, Ignacio Aracil-Bolaños, Jesús Pérez-Pérez, Antonia Campolongo, Cristina Izquierdo, Berta Pascual-Sedano, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2022
Response to letter: “Association of elevated blood homocysteine with cognitive decline in early, untreated Parkinson's disease”
Frederic Sampedro, Saul Martínez-Horta, Jaime Kulisevsky
Journal of the Neurological Sciences, 2022
Measuring the functional impact of cognitive impairment in Huntington’s disease
Andrea Horta-Barba, Saül Martínez-Horta, Jesus Pérez-Pérez, Frederic Sampedro, Arnau Puig-Davi, Javier Pagonabarraga, Jaime Kulisevsky
Journal of Neurology, 2022
Tipping the scales: how clinical assessment shapes the neural correlates of Parkinson’s disease mild cognitive impairment
Ignacio Aracil-Bolaños, Frederic Sampedro, Juan Marín-Lahoz, Andrea Horta-Barba, Saül Martínez-Horta, José María Gónzalez-de-Echávarri, Jesús Pérez-Pérez, Helena Bejr-Kasem, Berta Pascual-Sedano, Mariángeles Botí, Antonia Campolongo, Cristina Izquierdo, Alexandre Gironell, Beatriz Gómez-Ansón, Jaime Kulisevsky, Javier Pagonabarraga
Brain Imaging and Behavior, 2022
Increased homocysteine levels correlate with cortical structural damage in Parkinson's disease
Frederic Sampedro, Saul Martínez-Horta, Andrea Horta-Barba, Michel J. Grothe, Miguel A. Labrador-Espinosa, Silvia Jesús, Astrid Adarmes-Gómez, Fátima Carrillo, Arnau Puig-Davi, Florinda Roldán Lora, Miquel Aguilar Barberá, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots Foraster, Javier Ruiz Martínez, Francisco Carrillo Padilla, Mercedes Pueyo Morlans, Isabel González Aramburu, Jon Infante Ceberio, Jorge Hernández Vara, Oriol de Fábregues-Boixar, Teresa de Deus Fonticoba, Asunción Ávila, Juan Carlos Martínez-Castrillo, Helena Bejr-Kasem, Antonia Campolongo, Berta Pascual-Sedano, Pablo Martínez-Martín, Diego Santos-García, Pablo Mir, Jaime Kulisevsky
Journal of the Neurological Sciences, 2022
Structure and Dynamics of Large-Scale Cognitive Networks in Huntington's Disease
Ignacio Aracil‐Bolaños, Saül Martínez‐Horta, Jose M. González‐de‐Echávarri, Frederic Sampedro, Jesús Pérez‐Pérez, Andrea Horta‐Barba, Antonia Campolongo, Cristina Izquierdo, Beatriz Gómez‐Ansón, Javier Pagonabarraga, Jaime Kulisevsky
Movement Disorders, 2022
Editorial: Neuroimaging of Cognitive and Neuropsychiatric Symptoms in Movement Disorders
Frederic Sampedro, Estela Camara, Jaime Kulisevsky
Frontiers in Neurology, 2022
Intracortical surface-based MR diffusivity to investigate neurologic and psychiatric disorders: a review
Frederic Sampedro, Jaime Kulisevsky
Journal of Neuroimaging, 2022
Apathy Reflects Extra-Striatal Dopaminergic Degeneration in de novo Parkinson's Disease
Frederic Sampedro, Saul Martínez-Horta, Juan Marín-Lahoz, Javier Pagonabarraga, Jaime Kulisevsky
Journal of Parkinson S Disease, 2022
A Functional Connectivity Study to Investigate the Role of the Right Anterior Insula in Modulating Emotional Dysfunction in Borderline Personality Disorder
Frederic Sampedro, Ignacio Aracil-Bolaños, Cristina Carmona i Farrés, Joaquim Soler, Carlos Schmidt, Matilde Elices, Edith Pomarol-Clotet, Raymond Salvador, Daniel Vega, Juan C. Pascual
Psychosomatic Medicine, 2022
The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A
Genís Ona, Frederic Sampedro, Sergio Romero, Marta Valle, Valle Camacho, Carolina Migliorelli, Miguel Ángel Mañanas, Rosa Maria Antonijoan, Montserrat Puntes, Jimena Coimbra, Maria Rosa Ballester, Maite Garrido, Jordi Riba
International Journal of Neuropsychopharmacology, 2022
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: Stemming the tide?
Ignacio Aracil‐Bolaños, Frederic Sampedro, Jesus Pujol, Carles Soriano‐Mas, José María Gónzalez‐de‐Echávarri, Jaime Kulisevsky, Javier Pagonabarraga
Human Brain Mapping, 2021
Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease
Frederic Sampedro, Saul Martinez‐Horta, Jesús Pérez‐Pérez, Rocio Perez‐Gonzalez, Andrea Horta‐Barba, Antonia Campolongo, Ignacio Aracil‐Bolaños, Beatriz Gomez‐Anson, Jaume Kulisevsky
Annals of Clinical and Translational Neurology, 2021
Structural brain abnormalities in borderline personality disorder correlate with clinical severity and predict psychotherapy response
Frederic Sampedro, Cristina Carmona i Farrés, Joaquim Soler, Matilde Elices, Carlos Schmidt, Iluminada Corripio, Elisabet Domínguez-Clavé, Edith Pomarol-Clotet, Raymond Salvador, Juan C. Pascual
Brain Imaging and Behavior, 2021
Cognitive and behavioral profile of progressive supranuclear palsy and its phenotypes
Andrea Horta-Barba, Javier Pagonabarraga, Saül Martínez-Horta, Laura Busteed, Berta Pascual-Sedano, Ignacio Illán-Gala, Juan Marin-Lahoz, Ignacio Aracil-Bolaños, Jesús Pérez-Pérez, Frederic Sampedro, Helena Bejr-Kasem, Jaime Kulisevsky
Journal of Neurology, 2021
Defective involuntary attention to novelty in type 1 diabetes and impaired awareness of hypoglycaemia
Nicole Stantonyonge, Saul Martinez-Horta, Frederic Sampedro, María Belén Sánchez-Saudinós, Ana Chico
Diabetes Research and Clinical Practice, 2021
Grey matter microstructural alterations in schizophrenia patients with treatment-resistant auditory verbal hallucinations
Frederic Sampedro, Alexandra Roldán, Anna Alonso-Solís, Eva Grasa, Maria J. Portella, Eduardo J. Aguilar, Fidel Núñez-Marín, Beatriz Gómez-Ansón, Iluminada Corripio
Journal of Psychiatric Research, 2021
Robot-induced hallucinations in Parkinson’s disease depend on altered sensorimotor processing in fronto-temporal network
Fosco Bernasconi, Eva Blondiaux, Jevita Potheegadoo, Giedre Stripeikyte, Javier Pagonabarraga, Helena Bejr-Kasem, Michela Bassolino, Michel Akselrod, Saul Martinez-Horta, Frederic Sampedro, Masayuki Hara, Judit Horvath, Matteo Franza, Stéphanie Konik, Matthieu Bereau, Joseph-André Ghika, Pierre R. Burkhard, Dimitri Van De Ville, Nathan Faivre, Giulio Rognini, Paul Krack, Jaime Kulisevsky, Olaf Blanke
Science Translational Medicine, 2021
Cortical microstructural correlates of plasma neurofilament light chain in Huntington's disease
Frederic Sampedro, Jesus Pérez-Pérez, Saul Martínez-Horta, Rocío Pérez-González, Andrea Horta-Barba, Antonia Campolongo, Cristina Izquierdo, Javier Pagonabarraga, Beatriz Gómez-Ansón, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2021
Quantitative evaluation of oculomotor disturbances in progressive supranuclear palsy
Javier Pagonabarraga, Andrea Horta-Barba, Laura Busteed, Helena Bejr-kasem, Ignacio Illán-Gala, Ignacio Aracil-Bolaños, Juan Marín-Lahoz, Berta Pascual-Sedano, Jesús Pérez, Antonia Campolongo, Cristina Izquierdo, Saul Martinez-Horta, Frederic Sampedro, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2021
Minor hallucinations reflect early gray matter loss and predict subjective cognitive decline in Parkinson's disease
H. Bejr‐kasem, F. Sampedro, J. Marín‐Lahoz, S. Martínez‐Horta, J. Pagonabarraga, J. Kulisevsky
European Journal of Neurology, 2021
Structural Gray and White Matter Differences in Patients with Type 1 Diabetes and Impaired Awareness of Hypoglycemia
Nicole Stantonyonge, Frederic Sampedro, Jorge Méndez, Saül Martínez-Horta, Ana Chico, Beatriz Gómez-Anson
Journal of Clinical Endocrinology and Metabolism, 2021
Structural brain correlates of irritability and aggression in early manifest Huntington’s disease
Saul Martinez-Horta, Frederic Sampedro, Andrea Horta-Barba, Jesús Perez-Perez, Javier Pagonabarraga, Beatriz Gomez-Anson, Jaime Kulisevsky
Brain Imaging and Behavior, 2021
Correction to: Utility of the Parkinson’s disease-Cognitive Rating Scale for the screening of global cognitive status in Huntington’s disease (Journal of Neurology, (2020), 267, 5, (1527-1535), 10.1007/s00415-020-09730-6)
Cognitive Phenotype Working Group of the European Huntington’s Disease Network, Saul Martinez-Horta, Andrea Horta-Barba, Jesús Perez-Perez, Frederic Sampedro, Natascia de Lucia, Giuseppe De Michele, Stefanie Kehrer, Josef Priller, Simone Migliore, Ferdinando Squitieri, Anna Castaldo, Caterina Mariotti, Veronica Mañanes, Jose Luis Lopez-Sendon, Noelia Rodriguez, Asunción Martinez-Descals, Pedro Garcia-Ruiz, Filipa Júlio, Cristina Januário, Marianna Delussi, Marina de Tommaso, Sandra Noguera, Jesus Ruiz-Idiago, Emilia J. Sitek, Angela Nuzzi, Javier Pagonabarraga, Jaime Kulisevsky
Journal of Neurology, 2021
Increased cerebral FDG-PET uptake in type 1 diabetes patients with impaired awareness of hypoglycaemia
Frederic Sampedro, Nicole Stantonyonge, Saul Martínez‐Horta, Nicoleta Nan, Valle Camacho, Ana Chico
Journal of Neuroendocrinology, 2021
Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease
Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Valle Camacho, Diego-Alfonso Lopez-Mora, Javier Pagonabarraga, Jaime Kulisevsky
Neurobiology of Aging, 2021
Cognitive and Affective Empathy in Huntington's Disease
Arnau Puig-Davi, Saul Martinez-Horta, Frederic Sampedro, Andrea Horta-Barba, Jesus Perez-Perez, Antonia Campolongo, Cristina Izquierdo-Barrionuevo, Javier Pagonabarraga, Beatriz Gomez-Anson, Jaime Kulisevsky
Journal of Huntington S Disease, 2021
Arithmetic Word-Problem Solving as Cognitive Marker of Progression in Pre-Manifest and Manifest Huntington's Disease
Andrea Horta-Barba, Saul Martinez-Horta, Jesús Perez-Perez, Frederic Sampedro, Natascia de Lucia, Giuseppe De Michele, Elena Salvatore, Stefanie Kehrer, Josef Priller, Simone Migliore, Ferdinando Squitieri, Anna Castaldo, Caterina Mariotti, Veronica Mañanes, Jose Luis Lopez-Sendon, Noelia Rodriguez, Asunción Martinez-Descals, Filipa Júlio, Cristina Janurio, Marianna Delussi, Marina de Tommaso, Sandra Noguera, Jesus Ruiz-Idiago, Emilia J. Sitek, Renata Wallner, Angela Nuzzi, Javier Pagonabarraga, Jaime Kulisevsky, on behalf the Cognitive Phenotype Working Group of the European Huntington’s Disease Network
Journal of Huntington S Disease, 2021
Author response to Wang et al. Blood neurofilament light chain in Parkinson's disease: A biological marker for prediction of cognitive impairment?
Frederic Sampedro, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2020
Preservation of brain metabolism in recently diagnosed Parkinson’s impulse control disorders
Juan Marín-Lahoz, Frederic Sampedro, Andrea Horta-Barba, Saül Martínez-Horta, Ignacio Aracil-Bolaños, Valle Camacho, Helena Bejr-kasem, Berta Pascual-Sedano, Jesús Pérez-Pérez, Alexandre Gironell, Javier Pagonabarraga, Ignasi Carrió, Jaime Kulisevsky
European Journal of Nuclear Medicine and Molecular Imaging, 2020
Measuring impulsivity in Parkinson’s disease: a correlational and structural neuroimaging study using different tests
J. Marín‐Lahoz, S. Martínez‐Horta, F. Sampedro, J. Pagonabarraga, A. Horta‐Barba, H. Bejr‐kasem, M. Á. Botí, R. Fernández‐Bobadilla, B. Pascual‐Sedano, J. Pérez‐Pérez, I. Aracil‐Bolaños, A. Gironell, B. Gómez‐Ansón, J. Kulisevsky
European Journal of Neurology, 2020
Increased plasma neurofilament light chain levels in patients with type-1 diabetes with impaired awareness of hypoglycemia
Frederic Sampedro, Nicole Stantonyonge, Saül Martínez-Horta, Daniel Alcolea, Alberto Lleó, Laia Muñoz, Rocío Pérez-González, Juan Marín-Lahoz, Beatriz Gómez-Ansón, Ana Chico
BMJ Open Diabetes Research and Care, 2020
Corrigendum: Depression as a Risk Factor for Impulse Control Disorders in Parkinson Disease (Annals of Neurology, (2020), 87, 6, (939-949), 10.1002/ana.25731)
Juan Marín‐Lahoz, Frederic Sampedro, Saül Martinez‐Horta, Javier Pagonabarraga, Jaime Kulisevsky
Annals of Neurology, 2020
Brain metabolic changes in patients with treatment resistant schizophrenia treated with deep brain stimulation: A series of cases
Alexandra Roldán, Maria J. Portella, Frederic Sampedro, Anna Alonso-Solís, Salvador Sarró, Mireia Rabella, Eva M. Grasa, Enric Álvarez, Rodrigo Rodríguez, Valle Camacho, Alejandro Fernandez-León, Francisco Fuentes, Josefina Pérez-Blanco, Víctor Pérez, Peter Mckenna, Edith Pomarol-Clotet, Iluminada Corripio
Journal of Psychiatric Research, 2020
Serum neurofilament light chain levels reflect cortical neurodegeneration in de novo Parkinson's disease
Frederic Sampedro, Rocío Pérez-González, Saul Martínez-Horta, Juan Marín-Lahoz, Javier Pagonabarraga, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2020
Utility of the Parkinson’s disease-Cognitive Rating Scale for the screening of global cognitive status in Huntington’s disease
Cognitive Phenotype Working Group of the European Huntington’s Disease Network, Saul Martinez-Horta, Andrea Horta-Barba, Jesús Perez-Perez, Frederic Sampedro, Natascia de Lucia, Giuseppe De Michele, Stefanie Kehrer, Josef Priller, Simone Migliore, Ferdinando Squitieri, Anna Castaldo, Caterina Mariotti, Veronica Mañanes, Jose Luis Lopez-Sendon, Noelia Rodriguez, Asunción Martinez-Descals, Pedro Garcia-Ruiz, Filipa Júlio, Cristina Januário, Marianna Delussi, Marina de Tommaso, Sandra Noguera, Jesus Ruiz-Idiago, Emilia J. Sitek, Angela Nuzzi, Javier Pagonabarraga, Jaime Kulisevsky
Journal of Neurology, 2020
The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates
Andrea Horta-Barba, Javier Pagonabarraga, Saül Martínez-Horta, Juan Marín-Lahoz, Frederic Sampedro, Ramón Fernández-Bobadilla, M. Ángeles Botí, Helena Bejr-Kasem, Ignacio Aracil-Bolaños, Jesus Pérez-Pérez, Berta Pascual-Sedano, Antonia Campolongo, Cristina Izquierdo, Beatriz Gómez-Ansón, Jaime Kulisevsky
Frontiers in Neurology, 2020
Reduced gray matter volume in cognitively preserved COMT 158Val/Val Parkinson’s disease patients and its association with cognitive decline
Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Javier Pagonabarraga, Jaime Kulisevsky
Brain Imaging and Behavior, 2020
Autoscopic phenomena as an atypical psychiatric presentation of Huntington's disease: A case report including longitudinal clinical and neuroimaging data
Saul Martínez-Horta, Jesús Perez-Perez, Javier Pagonabarraga, Frederic Sampedro, Andrea Horta-Barba, Olaf Blanke, Jaime Kulisevsky
Cortex, 2020
CLU rs11136000 promotes early cognitive decline in Parkinson's disease
Frederic Sampedro, Juan Marín‐Lahoz, Saul Martínez‐Horta, Rocío Pérez‐González, Javier Pagonabarraga, Jaime Kulisevsky
Movement Disorders, 2020
Impaired face-like object recognition in premanifest Huntington's disease
Saul Martínez-Horta, Andrea Horta-Barba, Jesús Perez-Perez, Mizar Antoran, Javier Pagonabarraga, Frederic Sampedro, Jaime Kulisevsky
Cortex, 2020
Structural brain correlates of dementia in Huntington's disease
Saul Martinez-Horta, Frederic Sampedro, Andrea Horta-Barba, Jesús Perez-Perez, Javier Pagonabarraga, Beatriz Gomez-Anson, Jaime Kulisevsky
Neuroimage Clinical, 2020
APP-derived peptides reflect neurodegeneration in frontotemporal dementia
Ignacio Illán‐Gala, Jordi Pegueroles, Victor Montal, Daniel Alcolea, Eduard Vilaplana, Alexandre Bejanin, Sergi Borrego‐Écija, Frederic Sampedro, Andrea Subirana, María‐Belén Sánchez‐Saudinós, Ricard Rojas‐García, Hugo Vanderstichele, Rafael Blesa, Jordi Clarimón, Anna Antonell, Albert Lladó, Raquel Sánchez‐Valle, Juan Fortea, Alberto Lleó
Annals of Clinical and Translational Neurology, 2019
Longitudinal intracortical diffusivity changes in de-novo Parkinson's disease: A promising imaging biomarker
Frederic Sampedro, Saul Martínez-Horta, Juan Marín-Lahoz, Javier Pagonabarraga, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2019
Depression as a Risk Factor for Impulse Control Disorders in Parkinson Disease
Juan Marín‐Lahoz, Frederic Sampedro, Saül Martinez‐Horta, Javier Pagonabarraga, Jaime Kulisevsky
Annals of Neurology, 2019
Pattern of cortical thinning associated with the BDNF Val66Met polymorphism in Parkinson's disease
Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Javier Pagonabarraga, Jaime Kulisevsky
Behavioural Brain Research, 2019
Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse
Daniel Alcolea, Jordi Pegueroles, Laia Muñoz, Valle Camacho, Diego López‐Mora, Alejandro Fernández‐León, Nathalie Le Bastard, Els Huyck, Alicia Nadal, Verónica Olmedo, Frederic Sampedro, Victor Montal, Eduard Vilaplana, Jordi Clarimón, Rafael Blesa, Juan Fortea, Alberto Lleó
Annals of Clinical and Translational Neurology, 2019
A divergent breakdown of neurocognitive networks in Parkinson's Disease mild cognitive impairment
Ignacio Aracil‐Bolaños, Frederic Sampedro, Juan Marín‐Lahoz, Andrea Horta‐Barba, Saül Martínez‐Horta, Mariángeles Botí, Jesús Pérez‐Pérez, Helena Bejr‐Kasem, Berta Pascual‐Sedano, Antonia Campolongo, Cristina Izquierdo, Alexandre Gironell, Beatriz Gómez‐Ansón, Jaime Kulisevsky, Javier Pagonabarraga
Human Brain Mapping, 2019
Cortical atrophic-hypometabolic dissociation in the transition from premanifest to early-stage Huntington’s disease
Frederic Sampedro, Saul Martínez-Horta, Jesús Perez-Perez, Andrea Horta-Barba, Diego Alfonso Lopez-Mora, Valle Camacho, Alejandro Fernández-León, Beatriz Gomez-Anson, Ignasi Carrió, Jaime Kulisevsky
European Journal of Nuclear Medicine and Molecular Imaging, 2019
Clinical manifestations of homozygote allele carriers in Huntington disease
Esther Cubo, Saul-Indra Martinez-Horta, Frederic Sampedro Santalo, Asunción Martínez Descalls, Sara Calvo, Cecilia Gil-Polo, Ignacio Muñoz, Katia Llano, Natividad Mariscal, Dolores Diaz, Aranzazu Gutierrez, Laura Aguado, María A. Ramos-Arroyo, for the European HD Network
Neurology, 2019
Dopaminergic degeneration induces early posterior cortical thinning in Parkinson's disease
Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Javier Pagonabarraga, Jaime Kulisevsky
Neurobiology of Disease, 2019
The impact of bilingualism on brain structure and function in Huntington's disease
Saul Martínez-Horta, Andrea Moreu, Jesús Perez-Perez, Frederic Sampedro, Andrea Horta-Barba, Javier Pagonabarraga, Beatriz Gomez-Anson, Gloria Andrea Lozano-Martinez, Diego Alfonso Lopez-Mora, Valle Camacho, Alejandro Fernández-León, Ignasi Carrió, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2019
Widespread increased diffusivity reveals early cortical degeneration in huntington disease
F. Sampedro, S. Martínez-Horta, J. Perez-Perez, A. Horta-Barba, J. Martin-Lahoz, A. Alonso-Solís, I. Corripio, B. Gomez-Anson, J. Kulisevsky
American Journal of Neuroradiology, 2019
Selection of reference regions to model neurodegeneration in huntington disease by 18 F-FDG PET/CT using imaging and clinical parameters
Diego Alfonso López Mora, Frederic Sampedro, Valle Camacho, Alejandro Fernández, Francisco Fuentes, Joan Duch, Jesús Pérez-Perez, Saül Martínez-Horta, Juan Marín-Lahoz, Anna Domènech, Albert Flotats, Montserrat Estorch, Jaime Kulisevsky, Ignasi Carrió
Clinical Nuclear Medicine, 2019
Disruption of the default mode network and its intrinsic functional connectivity underlies minor hallucinations in Parkinson's disease
Helena Bejr‐kasem, Javier Pagonabarraga, Saül Martínez‐Horta, Frederic Sampedro, Juan Marín‐Lahoz, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Jesús Pérez‐Pérez, M. Ángeles Botí, Antonia Campolongo, Cristina Izquierdo, Berta Pascual‐Sedano, Beatriz Gómez‐Ansón, Jaime Kulisevsky
Movement Disorders, 2019
Structural and metabolic brain correlates of apathy in Huntington's disease
Saul Martínez‐Horta, Jesús Perez‐Perez, Frederic Sampedro, Javier Pagonabarraga, Andrea Horta‐Barba, Mar Carceller‐Sindreu, Beatriz Gomez‐Anson, Gloria Andrea Lozano‐Martinez, Diego Alfonso Lopez‐Mora, Valle Camacho, Alejandro Fernández‐León, Ignasi Carrió, Jaime Kulisevsky
Movement Disorders, 2018
Early gray matter volume loss in MAPT H1H1 de Novo PD patients: A possible association with cognitive decline
Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Javier Pagonabarraga, Jaime Kulisevsky
Frontiers in Neurology, 2018
Cortical Thinning Associated with Age and CSF Biomarkers in Early Parkinson’s Disease Is Modified by the SNCA rs356181 Polymorphism
Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Javier Pagonabarraga, Jaime Kulisevsky
Neurodegenerative Diseases, 2018
Non-demented Parkinson’s disease patients with apathy show decreased grey matter volume in key executive and reward-related nodes
Saul Martinez-Horta, Frederic Sampedro, Javier Pagonabarraga, Ramón Fernandez-Bobadilla, Juan Marin-Lahoz, Jordi Riba, Jaime Kulisevsky
Brain Imaging and Behavior, 2017
Assessing the psychedelic "after-glow" in ayahuasca users: Post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacities
Frederic Sampedro, Mario de la Fuente Revenga, Marta Valle, Natalia Roberto, Elisabet Domínguez-Clavé, Matilde Elices, Luís Eduardo Luna, José Alexandre S Crippa, Jaime E C Hallak, Draulio B de Araujo, Pablo Friedlander, Steven A Barker, Enrique Álvarez, Joaquim Soler, Juan C Pascual, Amanda Feilding, Jordi Riba
International Journal of Neuropsychopharmacology, 2017
Longitudinal brain structural changes in preclinical Alzheimer's disease
Jordi Pegueroles, Eduard Vilaplana, Victor Montal, Frederic Sampedro, Daniel Alcolea, Maria Carmona‐Iragui, Jordi Clarimon, Rafael Blesa, Alberto Lleó, Juan Fortea, Alzheimer's Disease Neuroimaging Initiative
Alzheimer S and Dementia, 2017
Cocaine addiction is associated with abnormal prefrontal function, increased striatal connectivity and sensitivity to monetary incentives, and decreased connectivity outside the human reward circuit
Lucía Vaquero, Estela Cámara, Frederic Sampedro, José Pérez de los Cobos, Francesca Batlle, Josep Maria Fabregas, Joan Artur Sales, Mercè Cervantes, Xavier Ferrer, Gerardo Lazcano, Antoni Rodríguez‐Fornells, Jordi Riba
Addiction Biology, 2017
Computing quantitative indicators of structural renal damage in pediatric DMSA scans
F. Sampedro, A. Domenech, S. Escalera, I. Carrio
Revista Espanola De Medicina Nuclear E Imagen Molecular, 2017
Striatal hypometabolism in premanifest and manifest Huntington’s disease patients
Diego Alfonso López-Mora, Valle Camacho, Jesús Pérez-Pérez, Saül Martínez-Horta, Alejandro Fernández, Frederic Sampedro, Alberto Montes, Gloria Andrea Lozano-Martínez, Beatriz Gómez-Anson, Jaime Kulisevsky, Ignasi Carrió
European Journal of Nuclear Medicine and Molecular Imaging, 2016
Erratum: Corrigendum to “Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's disease” (Parkinsonism and Related Disorders (2016) 25C (58–64) (S1353802016300360) (10.1016/j.parkreldis.2016.02.008))
Saul Martinez-Horta, Jesus Perez-Perez, Erik van Duijn, Ramon Fernandez-Bobadilla, Mar Carceller, Javier Pagonabarraga, Berta Pascual-Sedano, Antonia Campolongo, Jesus Ruiz-Idiago, Frederic Sampedro, G. Bernhard Landwehrmeyer, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2016
Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's Disease
Saul Martinez-Horta, Jesus Perez-Perez, Erik van Duijn, Ramon Fernandez-Bobadilla, Mar Carceller, Javier Pagonabarraga, Berta Pascual-Sedano, Antonia Campolongo, Jesus Ruiz-Idiago, Frederic Sampedro, G.Bernhard Landwehrmeyer, Jaime Kulisevsky
Parkinsonism and Related Disorders, 2016
Cerebrospinal Fluid Anti-Amyloid-Beta; Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation
María Carmona-Iragui, Ana Fernández-Arcos, Daniel Alcolea, Fabrizio Piazza, Estrella Morenas-Rodriguez, Sofía Antón-Aguirre, Isabel Sala, Jordi Clarimon, Oriol Dols-Icardo, Valle Camacho, Frederic Sampedro, Josep Munuera, Fidel Nuñez-Marin, Alberto Lleó, Juan Fortea, Beatriz Gómez-Ansón, Rafael Blesa
Journal of Alzheimer S Disease, 2016
Effect of REST on brain metabolism in the Alzheimer disease continuum
Oriol Dols‐Icardo, Eduard Vilaplana, Frederic Sampedro, Daniel Alcolea, Olivia Belbin, Valle Camacho, Rafael Blesa, Alberto Lleó, Jordi Clarimón, Juan Fortea, for the Alzheimer's Disease Neuroimaging Initiative
Annals of Neurology, 2015
Telling true from false: Cannabis users show increased susceptibility to false memories
J Riba, M Valle, F Sampedro, A Rodríguez-Pujadas, S Martínez-Horta, J Kulisevsky, A Rodríguez-Fornells
Molecular Psychiatry, 2015
Spatial codification of label predictions in multi-scale stacked sequential learning: A case study on multi-class medical volume segmentation
Frederic Sampedro, Sergio Escalera
Iet Computer Vision, 2015
Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease
Daniel Alcolea, Eduard Vilaplana, Jordi Pegueroles, Victor Montal, Pascual Sánchez-Juan, Andrea González-Suárez, Ana Pozueta, Eloy Rodríguez-Rodríguez, David Bartrés-Faz, Dídac Vidal-Piñeiro, Sofía González-Ortiz, Santiago Medrano, María Carmona-Iragui, MaBelén Sánchez-Saudinós, Isabel Sala, Sofía Anton-Aguirre, Frederic Sampedro, Estrella Morenas-Rodríguez, Jordi Clarimón, Rafael Blesa, Alberto Lleó, Juan Fortea
Neurobiology of Aging, 2015
Deriving global quantitative tumor response parameters from 18F-FDG PET-CT scans in patients with non-Hodgkin's lymphoma
Frederic Sampedro, Anna Domenech, Sergio Escalera, Ignasi Carrió
Nuclear Medicine Communications, 2015
Automatic tumor volume segmentation in whole-body PET/CT scans: A supervised learning approach
Frederic Sampedro, Sergio Escalera, Anna Domenech, Ignasi Carrio
Journal of Medical Imaging and Health Informatics, 2015
APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
Frederic Sampedro, for the Alzheimer’s Disease Neuroimaging Initiative, Eduard Vilaplana, Mony J de Leon, Daniel Alcolea, Jordi Pegueroles, Victor Montal, María Carmona-Iragui, Isabel Sala, María-Belén Sánchez-Saudinos, Sofía Antón-Aguirre, Estrella Morenas-Rodríguez, Valle Camacho, Carles Falcón, Javier Pavía, Domènec Ros, Jordi Clarimón, Rafael Blesa, Alberto Lleó, Juan Fortea
Oncotarget, 2015
A computational framework for cancer response assessment based on oncological PET-CT scans
Frederic Sampedro, Sergio Escalera, Anna Domenech, Ignasi Carrio
Computers in Biology and Medicine, 2014
Iterative multi-class multi-scale stacked sequential learning: Definition and application to medical volume segmentation
Frederic Sampedro, Sergio Escalera, Anna Puig
Pattern Recognition Letters, 2014
Obtaining quantitative global tumoral state indicators based on whole-body PET/CT scans: A breast cancer case study
Frederic Sampedro, Anna Domenech, Sergio Escalera
Nuclear Medicine Communications, 2014
Static and dynamic computational cancer spread quantification in whole body FDG-PET/CT scans
Frederic Sampedro, Anna Domenech, Sergio Escalera
Journal of Medical Imaging and Health Informatics, 2014
Knowledge management and empowerment at a university hospital in the 21st century
Proceedings of the European Conference on Knowledge Management Eckm, 2012
Measuring and managing intellectual capital at a university hospital in the 21st century
Proceedings of the European Conference on Knowledge Management Eckm, 2012
Modular design of graph theory based software for scientific applications and education
Frederic Sampedro, Anna Puig, Antoni Benseny
22nd Spanish Computer Graphics Conference Ceig 2012, 2012

Frederic Sampedro

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