Seung Hyuk Yim

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Department of Surgery, Clinical Associate Professor
Yonsei University College of Medicine

Seung Hyuk Yim


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RESEARCH, TEACHING, or OTHER INTERESTS

Surgery, Transplantation
24

Scopus Publications

Scopus Publications

  • Clinical implications of early blood transfusion after kidney transplantation
    Minyu Kang, Hwa-Hee Koh, Seung Hyuk Yim, Mun Chae Choi, Hyun Jeong Kim, Hyung Woo Kim, Jaeseok Yang, Beom Seok Kim, Kyu Ha Huh, Myoug Soo Kim, Juhan Lee
    Scientific Reports, 2025
    Pre-transplantation red blood cell transfusion (RBCT) is a well-recognized cause of allosensitization. However, the effects of RBCT after kidney transplantation remain controversial. This study evaluates the impacts of RBCT within the first 30 days post-transplantation (early RBCT) with regard to long-term patient and graft outcomes. We retrospectively analyzed 785 patients who underwent HLA- and ABO-compatible kidney transplantation between 2014 and 2020. Patients were categorized based on whether they received early RBCT. Overall, 18.9% of patients received early RBCT. On multivariable analysis, early RBCT was independently associated with increased risks of all-cause mortality (hazard ratio, 2.264; 95% CI 1.186-4.324; P = 0.013) and death-censored graft loss (hazard ratio, 1.995; 95% CI 1.045-3.810; P = 0.036). Cumulative incidence of antibody-mediated rejection was significantly higher in the early RBCT group (P = 0.024). In the sensitivity analysis, the early RBCT significantly increased the risk of patient mortality (P = 0.017), death-censored graft loss (P = 0.018) and antibody-mediated rejection (P = 0.05), regardless of the donor profile. Early post-transplantation RBCT was associated with increased risks of all-cause mortality, graft loss, and antibody-mediated rejection, highlighting the need for reconsideration of transfusion practices following kidney transplantation.
  • Association between low fasting glucose of the living donor and risk of graft loss in the recipient after liver transplantation
    Hwa-Hee Koh, Minyoung Lee, Minyu Kang, Seung Hyuk Yim, Mun Chae Choi, Eun-Ki Min, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim, Jae Seung Lee, Deok-Gie Kim
    Scientific Reports, 2025
    Several donor-specific factors influence the functional recovery and long-term outcomes of liver grafts. This study investigated the association between donor fasting glucose (DFG) and recipient outcomes after living donor liver transplantation (LDLT) in 950 cases at a single center. Patients were divided into two groups: low-DFG (< 85 mg/dL, n = 120) and control (≥ 85 mg/dL, n = 830). The five-year graft survival rate was significantly lower in the low-DFG group (71.5%) compared to the control group (80.0%) (P = 0.02). Multivariable Cox regression analysis showed that low DFG was independently associated with graft loss (hazard ratio 1.72, 95% CI 1.15-2.56, P = 0.008). In propensity score-matched groups, the low-DFG group also had lower survival rates (71% vs. 83.1%, P = 0.004). The presence of additional risk factors, such as low graft-to-recipient weight ratio, older donor age, and longer cold ischemic time, further reduced graft survival in the low-DFG group. A DFG level < 85 mg/dL is associated with higher risk of graft failure after LDLT, especially when combined with other risk factors. Low DFG should be considered a prognostic marker in LDLT planning, with potential to improve patient outcomes as further research clarifies the underlying pathophysiological mechanisms.
  • Correction to: Association between low fasting glucose of the living donor and risk of graft loss in the recipient after liver transplantation (Scientific Reports, (2025), 15, 1, (951), 10.1038/s41598-024-80604-x)
    Hwa-Hee Koh, Minyoung Lee, Minyu Kang, Seung Hyuk Yim, Mun Chae Choi, Eun-Ki Min, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim, Jae Seung Lee, Deok-Gie Kim
    Scientific Reports, 2025
    In the original version of this Article, Jae Seung Lee was omitted as a corresponding author. Correspondence and requests for materials should also be addressed to sikarue@yuhs.ac.
  • Cytomegalovirus Infection in Seropositive Kidney Transplant Recipients With Diverse Immunological Risks Under Preemptive Strategy
    Mun Chae Choi, Minyu Kang, Hwa‐hee Koh, Seung Hyuk Yim, Hyun Jeong Kim, Su Jin Jung, Hyung Woo Kim, Jaeseok Yang, Beom Seok Kim, Kyu Ha Huh, Myoung Soo Kim, Juhan Lee
    Journal of Medical Virology, 2025
    Cytomegalovirus (CMV) infection remains the most prevalent viral infection in kidney transplant recipients. Despite effective preventive strategies, the use of desensitization therapies and potent immunosuppressive agents in patients with high immunological risks underscores the continued importance of CMV as a major concern. This study aims to determine the incidence and outcomes of CMV infection in patients with diverse immunological risks under preemptive stategies. We analyzed 614 CMV‐seropositive kidney transplant recipients managed under preemptive strategies. Of them, 231 patients (37.6%) underwent immunologically incompatible transplantation, including 75 ABO‐ and 156 HLA‐incompatible transplants. During the median follow‐up of 60 months, 354 patients (57.7%) experienced CMV infection. Multivariable analysis identified older recipient age, deceased donor, rituximab, and anti‐thymocyte globulin as independent risk factors for CMV infection, while the use of mammalian target of rapamycin inhibitor was protective. Multivariable Cox regression analysis confirmed that CMV infection was independently associated with increased risks of death‐censored graft loss (adjusted hazard ratio [aHR], 2.05; 95% confidence interval [CI], 1.17–3.59) and all‐cause mortality (aHR, 3.40; 95% CI, 1.60–7.23). CMV infection adversely affects graft and patient outcomes in seropositive recipients managed under preemptive strategies. These findings emphasize the need for optimized CMV prevention strategies in recipients with high immunological risks, hereby intensified preemptive strategies or immunological risk‐adapted antiviral prophylaxis are key options.
  • Robust Predictive Performance of the SALT-M Score for Clinical Outcomes in Asian Patients With Acute-on-Chronic Liver Failure
    Kunhee Kim, Seung Hyuk Yim, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim, Jun Yong Park, Sang Hoon Ahn, Deok‐Gie Kim, Hye Won Lee
    Alimentary Pharmacology and Therapeutics, 2025
    BackgroundAcute‐on‐chronic liver failure (ACLF) is a syndrome of patients with chronic liver disease presenting with multiple organ failures. Recently, Sundaram‐ACLF‐LT Mortality (SALT‐M) score has been developed to predict 1‐year post‐liver transplantation mortality. We validated the SALT‐M score in a large‐volume, Asian single‐centre cohort.AimsWe validated the SALT‐M score in a large‐volume, Asian single‐centre cohort.MethodsWe analysed 224 patients of ACLF grade 2–3. Area under the receiver operating characteristic curve (AUROC) and concordance index (c‐index) were used to assess and compare the predictability of posttransplant mortality of SALT‐M and other scores. Moreover, we compared the survivals of patients with high and low SALT‐M, in conjunction with MELD score and ACLF grade.ResultsThe AUROC for prediction of 1‐year post‐LT survival was higher in SALT‐M (0.691) than in MELD, MELD‐Na, MELD 3.0 and delta‐MELD. Similarly, the c‐index of the SALT‐M (0.650) was higher than aforementioned MELD systems. When categorised by the cut‐off of SALT‐M ≥ 20 and MELD ≥ 30, patients with high SALT‐M exhibited lower post‐LT survival than those with low SALT‐M scores regardless of high or low MELD (40.0% for high SALT‐M/high MELD vs. 42.9% for high SALT‐M/low MELD vs. 73.8% for low SALT‐M/high MELD vs. 63.7% for low SALT‐M/low MELD, p &lt; 0.001). In patients with ACLF grade 3, SALT‐M effectively stratified the posttransplant mortality (39.4% for high SALT‐M vs. 63.1% for low SALT‐M, p = 0.018).ConclusionsSALT‐M outperformed previous MELD systems for predicting posttransplant mortality in Asian LT cohort with severe ACLF. Transplantability for patients with severe ACLF could be determined based on SALT‐M.
  • Corrigendum: Number of Pretransplant Therapeutic Plasma Exchange Sessions Increase the Recurrence Risk of Hepatocellular Carcinoma in ABO-Incompatible Living Donor Liver Transplantation (Transplant International, (2025), 38, (14304), 10.3389/ti.2025.14304)
    Young Jin Yoo, Deok-Gie Kim, Eun-Ki Min, Seung Hyuk Yim, Mun Chae Choi, Hwa-Hee Koh, Minyu Kang, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo
    Transplant International, 2025
    Text Correction In the published article, there was an error regarding the corresponding authorship. The article omitted the designation of Deok-Gie Kim as a co-corresponding author. Yoo et al. TPE and ABOi LDLT Oncology Meg Carbery A correction has been made to Author Information section, from paragraph 20. "The corresponding authors are Dong Jin Joo, djjoo@yuhs.ac and Deok-Gie Kim, mppl01@yuhs.ac." Here's a corrected paragraph below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
  • Number of Pretransplant Therapeutic Plasma Exchange Sessions Increase the Recurrence Risk of Hepatocellular Carcinoma in ABO-Incompatible Living Donor Liver Transplantation
    Young Jin Yoo, Deok-Gie Kim, Eun-Ki Min, Seung Hyuk Yim, Mun Chae Choi, Hwa-Hee Koh, Minyu Kang, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo
    Transplant International, 2025
    Previous studies have reported comparable oncologic outcome between ABO-incompatible (ABOi) living donor liver transplantation (LDLT) and ABO-compatible (ABOc) LDLT in patients with hepatocellular carcinoma (HCC). We aimed to analyze the relationship between number of therapeutic plasma exchanges (TPE) before LDLT and HCC outcomes in ABOi LDLT. In this single-center retrospective study, 428 adult LDLT recipients with HCC were categorized into three groups according to ABO incompatibility and the number of pretransplant TPE: ABOc (n = 323), ABOi/TPE ≤5 (n = 75), and ABOi/TPE ≥6 (n = 30). The RFS and HCC recurrence rates were compared. Three groups showed similar characteristics in most demographics, pretransplant tumor markers and pathologies. The median initial isoagglutinin (IA) titer was 1:64 (range negative-1:512) in ABOi/TPE ≤5 group and 1:512 (range 1:128–1:4,096) in ABOi/TPE ≥6 group. Five-year RFS was significantly lower (75.7% vs. 72.7% vs. 50.0%, P = 0.005) and HCC recurrence was significantly higher in the ABOi/TPE ≥6 group than in the other groups(16.4% vs. 17.0% vs. 39.4%, P = 0.014). In multivariable Cox regression analysis, ABOi/TPE ≥6 was an independent risk factor for RFS (aHR 1.99, 95% CI:1.02–3.86, P = 0.042) and HCC recurrence (aHR 2.42, 95% CI:1.05–5.57, P = 0.037). More than six pretransplant TPE sessions may increase the risk of HCC recurrence after ABOi LDLT. Reducing TPE sessions to fewer than six should be considered while maintaining immunological stability through IA titer control.
  • Creatinine-cystatin C ratio and death with a functioning graft in kidney transplant recipients
    Mun Chae Choi, Deok Gie Kim, Seung Hyuk Yim, Hyun Jeong Kim, Hyoung Woo Kim, Jaeseok Yang, Beom Seok Kim, Kyu Ha Huh, Myoung Soo Kim, Juhan Lee
    Scientific Reports, 2024
    Death with a functioning graft is important cause of graft loss after kidney transplantation. However, little is known about factors predicting death with a functioning graft among kidney transplant recipients. In this study, we evaluated the association between post-transplant creatinine-cystatin C ratio and death with a functioning graft in 1592 kidney transplant recipients. We divided the patients into tertiles based on sex-specific creatinine-cystatin C ratio. Among the 1592 recipients, 39.5% were female, and 86.1% underwent living-donor kidney transplantation. The cut-off value for the lowest creatinine-cystatin C ratio tertile was 0.86 in males and 0.73 in females. The lowest tertile had a significantly lower 5-year patient survival rate and was independently associated with death with a functioning graft (adjusted hazard ratio 2.574, 95% confidence interval 1.339–4.950, P &lt; 0.001). Infection was the most common cause of death in the lowest tertile group, accounting for 62% of deaths. A low creatinine-cystatin C ratio was significantly associated with an increased risk of death with a functioning graft after kidney transplantation.
  • Learning Curve of Autologous Arteriovenous Fistula Formation for Junior Vascular Surgeons
    Mun Chae Choi, Seung Hyuk Yim, Seong Wook Shin, Seok Jeong Yang, Deok-Gie Kim, Seon-Hee Heo, Soo Jin Kim
    Vascular Specialist International, 2024
    Purpose Autologous arteriovenous fistulas (AVFs) are considered the gold standard for hemodialysis access, with outcomes largely dependent on the surgeon’s experience. Nevertheless, few studies have been conducted on the learning curve of junior vascular surgeons in AVF creation. This study aims to address this by examining the development of surgical skills among junior vascular surgeons. Materials and Methods A retrospective analysis was conducted on 100 patients who underwent autologous AVF procedures performed by five junior surgeons between January 2018 and December 2023. To establish the cutoff number of cases for the learning curve, we examined the cubic spline curve using the hazard ratio for primary failure. Results The cutoff number for operation cases was 15.33, and we divided the analysis into a pre-learning curve period (≤15 cases of AVF) and a post-learning curve period (>15 cases of AVF). The 1-year primary patency rate for AVF during the post-learning curve period was 84.0%, which was higher than the 65.5% rate observed during the pre-learning curve period. In a subgroup analysis based on AVF type, the radiocephalic fistula patient group demonstrated a significant increase in 1-year primary patency in the post-learning curve period compared to that in the pre-learning curve period (80.0% vs. 43.0%, log-rank P=0.033). In contrast, there was no significant difference in the primary patency rates between the post- and pre-learning curve periods in the brachiocephalic fistula patient group (90.0% vs. 89.2%, log-rank P=0.930). Conclusion Junior vascular surgeons demonstrated improved primary AVF patency beyond the learning curve benchmark in 15 patients, with particularly notable enhancements in radiocephalic fistulas.
  • High Number of Plasma Exchanges Increases the Risk of Bacterial Infection in ABO-incompatible Living Donor Liver Transplantation
    Mun Chae Choi, Eun-Ki Min, Seung Hyuk Yim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim
    Transplantation, 2024
    Background. Bacterial infections are major complications that cause significant mortality and morbidity in living donor liver transplantation (LDLT). The risk of bacterial infection has not been studied in ABO-incompatible (ABOi) recipients with a desensitization protocol in relation to the number of plasma exchanges (PEs). Therefore, we aimed to analyze the risk of bacterial infection in ABOi LDLT recipients with a high number of PEs compared with recipients with a low number of PEs. Methods. A retrospective study was performed with 681 adult LDLT recipients, of whom 171 ABOi LDLT recipients were categorized into the high (n = 52) or low (n = 119) PE groups based on a cutoff value of 6 PE sessions. We compared bacterial infections and postoperative bacteremia within 6 mo after liver transplantation with the ABO-compatible (ABOc) LDLT group (n = 510) as a control group. Results. The high PE group showed a bacterial infection rate of 49.9% and a postoperative bacteremia rate of 28.8%, which were significantly higher than those of the low PE group (31.1%, 17.8%) and the ABOc group (26.7%, 18.0%). In multivariate analysis, the high PE group was found to have a 2.4-fold higher risk of bacterial infection (P = 0.008). This group presented a lower 5-y survival rate of 58.6% compared with the other 2 groups (81.5% and 78.5%; P = 0.030 and 0.001). Conclusions. A high number of preoperative PEs increases bacterial infection rate and postoperative bacteremia in ABOi LDLT.
  • Benefits of statin therapy within a year after kidney transplantation
    Seung Hyuk Yim, Hyun Jeong Kim, Han Ro, Jung-Hwa Ryu, Myung-Gyu Kim, Jae Berm Park, Chan-Duck Kim, Seungyeup Han, Sik Lee, Jaesok Yang, Kyu Ha Huh, Myoung Soo Kim, Juhan Lee
    Scientific Reports, 2024
  • Clinical Impact and Risk Factors of Seizure After Liver Transplantation: A Nested Case-Control Study
    Minyu Kang, Hwa-Hee Koh, Deok-Gie Kim, Seung Hyuk Yim, Mun Chae Choi, Eun-Ki Min, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo
    Transplant International, 2024
  • Clinical relevance of the living kidney donor profile index in Korean kidney transplant recipients
    Hyun Jeong Kim, Eunki Min, Seung Hyuk Yim, Mun Chae Choi, Hyung Woo Kim, Jaeseok Yang, Beom Seok Kim, Kyu Ha Huh, Myoug Soo Kim, Juhan Lee
    Clinical Transplantation, 2024
  • One-way donor-to-recipient human leukocyte antigen mismatch and graft-versus-host disease in liver transplantation: an observational study of a single-center experience in Korea
    Seung Hyuk Yim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim
    Korean Journal of Transplantation, 2023
  • Cumulative exposure to tacrolimus during early period after liver transplantation does not affect the recurrence of hepatocellular carcinoma
    Deok-Gie Kim, Seung Hyuk Yim, Eun-Ki Min, Mun Chae Choi, Dong Jin Joo, Myoung Soo Kim, Jae Geun Lee
    Scientific Reports, 2023
  • Unusual grafts for living-donor liver transplantation
    Seung Hyuk Yim, Eun-Ki Min, Mun Chae Choi, Deok-Gie Kim, Dai Hoon Han, Dong Jin Joo, Jin Sub Choi, Myong Soo Kim, Gi Hong Choi, Jae Geun Lee
    European Journal of Medical Research, 2023
  • Survival benefit of living-donor liver transplantation in patients with a model for end-stage liver disease over 30 in a region with severe organ shortage: a retrospective cohort study
    Seung Hyuk Yim, Deok Gie Kim, Minyu Kang, Hwa Hee Koh, Mun Chae Choi, Eun Ki Min, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo
    International Journal of Surgery, 2023
  • Effect of statins on the recurrence of hepatocellular carcinoma after liver transplantation: An illusion revealed by exposure density sampling
    Deok‐Gie Kim, Seung Hyuk Yim, Eun‐Ki Min, Mun Chae Choi, Myoung Soo Kim, Dong Jin Joo, Jae Geun Lee
    Liver International, 2023
  • Risk factors for late-onset Pneumocystis jirovecii pneumonia in liver transplant recipients
    Eun-Ki Min, Juhan Lee, Su Jin Jeong, Deok-Gie Kim, Seung Hyuk Yim, Mun Chae Choi, Dong Jin Joo, Myoung Soo Kim, Jae Geun Lee
    International Journal of Infectious Diseases, 2023
  • Incidence, mortality, and risk factors associated with carbapenem-resistant Acinetobacter baumannii bacteremia within 30 days after liver transplantation
    Eun‐Ki Min, Seung Hyuk Yim, Mun Chae Choi, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim, Deok‐Gie Kim
    Clinical Transplantation, 2023
  • Risk Factors for Cytomegalovirus Infection and Its Impact on Survival after Living Donor Liver Transplantation in South Korea: A Nested Case-Control Study
    Seung Hyuk Yim, Mun Chae Choi, Deok-Gie Kim, Eun-Ki Min, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim
    Pathogens, 2023
  • Successful Recovery After Veno-Arterio-Venous Extracorporeal Membrane Oxygenation Immediately Before Liver Transplantation in Multi-Organ Failure Including Acute Respiratory Distress Syndrome: A Case Report
    Mun Chae Choi, Eun-Ki Min, Seung Hyuk Yim, Jae Geun Lee, Bon-Nyeo Koo, Hyohyun Kim, Hye Won Lee, Dong Jin Joo, Myoung Soo Kim
    Transplantation Proceedings, 2023
  • Predicted Impact of the Model for End-Stage Liver Disease 3.0 in a Region Suffering Severe Organ Shortage
    Deok-Gie Kim, Seung Hyuk Yim, Eun-Ki Min, Mun Chae Choi, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo
    Journal of Korean Medical Science, 2023
  • Successful treatment of renal malakoplakia via the reduction of immunosuppression and antimicrobial therapy after kidney transplantation: a case report
    Seung Hyuk Yim, Eun-Ki Min, Hyun Jeong Kim, Beom Jin Lim, Kyu Ha Huh
    Korean Journal of Transplantation, 2022