Enrique Gonzalez-Mateo
@upv.es
Scopus Publications
- Real-time ultrasound shear wave elastography using a local phase gradient
Enrique González-Mateo, Francisco Camarena, Noé Jiménez
Computer Methods and Programs in Biomedicine, 2025
BACKGROUND AND OBJECTIVE: Current approaches for ultrasound spectral elastography make use of block processing, resulting in long computational times. This work describes a real-time, robust, and quantitative imaging modality to map the elastic and viscoelastic properties of soft tissues using ultrasound. METHODS: This elastographic technique relies on the spectral estimation of the shear-wave phase speed by combining a local phase-gradient method and angular filtering. We first apply directional filtering in the spatio-temporal frequency domain for providing one-way, smooth, and harmonic displacement maps in the frequency range of interest. Thanks to this, we can apply a simple, fast, and local phase gradient approach to obtain the axial and lateral components of the wavevector, which are linked to phase velocity and soft-tissue elasticity and viscoelasticity. The technique is validated numerically and experimentally using a 7.6 MHz ultrasound probe, tested in calibrated soft-tissue phantoms and ex vivo liver tissues. The method is compared with state-of-the-art spectral methods. RESULTS: The technique significantly reduces the computation time, e.g., the reconstruction time for a 155 × 315-pixel phase-velocity map was 0.16 s, while local-phase velocity-imaging techniques was 156.73 s for 2D implementation and 13.56 s for the 1D version, a reduction between two and three orders of magnitude, while showing a similar accuracy and resolution than standard methods. CONCLUSIONS: This approach eliminates the need for block processing that may limit the spatial resolution and computational time of the velocity map. In this way, the phase gradient elastography method is revealed as an efficient and robust approach for real-time spectral elastography. - MLS-Coded ARF Excitation for Noise-Resilient Shear Wave Elastography
Enrique González-Mateo, Matthew Urban, Noé Jiménez
IEEE International Ultrasonics Symposium Ius, 2025
This study proposes a shear wave elastography (SWE) technique based on maximal length sequence (MLS) coded acoustic radiation force (ARF) excitation combined with frequency-domain pulse compression. The goal is to enable robust SWE measurements under low-voltage conditions where conventional single-push (SP) methods suffer from low signal-to-noise ratio (SNR) due to safety constraints on acoustic output. A 127-bit MLS sequence was used to modulate the ARF push, distributing the energy over long ARF excitations while maintaining a low peak voltage. After compression, the induced displacement fields exhibited impulse-like profiles with enhanced SNR. In vivo measurements were performed on the human biceps brachii using three excitation modes: high-voltage SP (60 V), low- voltage SP (20 V), and low-voltage MLS-coded excitation (20 V). Under low-voltage conditions, MLS increased the SNR from - 3.5 dB (SP) to 5.6 dB, recovered accurate group velocity estimates (5.26 m/s, R<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> = 0.93), and preserved stable phase velocity profiles up to 900 Hz. In contrast, low-voltage SP produced unreliable group velocity (−8.83 m/s, R<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> = 0.15) and degraded phase velocity at high frequencies. The results demonstrate that MLS-coded excitation enables high-quality SWE at reduced acoustic exposure, expanding its applicability to safety-sensitive tissues such as neonatal or lung. - Enhanced Real-Time Ultrasound Elastography with Phase Gradient
Enrique González-Mateo, Francisco Camarena, Noé Jiménez
IEEE Ultrasonics Ferroelectrics and Frequency Control Joint Symposium Uffc Js 2024 Proceedings, 2024
Elastography is a well-practiced, non-invasive technique for imaging mechanical deformations to quantify the stiffness of tissues. The current methods of estimating shear wave velocity may often be troubled by issues of viscoelastic dispersion and computational complexity. A new algorithm is proposed in this paper, where a combination of the angular spectrum method and a local phase gradient estimator improves wavenumber determination in shear wave elastography. Testing on phantoms with homogeneous, rigid, and soft inclusions was performed by this algorithm. The average phase velocity obtained in the phase velocity map was 1.58 m/s with a standard deviation of 0.05 m/s for the homogeneous phantom. On the other hand, in heterogeneous phantoms, velocities ranged from 1 to 3 m/s. The method achieved an average reconstruction time of 0.253 s by averaging over nine frequency bands and two push locations. This algorithm achieves much-reduced computational complexity for high accuracy scanning; therefore, it offers a great improvement toward real-time elastography applications. - Shear-Wave Pulse-Compression Elastography using a Modulated Acoustic Radiation Force Excitation
Enrique González-Mateo, Josep Rodríguez-Sendra, Francisco Camarena, Noé Jiménez
IEEE Ultrasonics Ferroelectrics and Frequency Control Joint Symposium Uffc Js 2024 Proceedings, 2024
Ultrasound shear wave elastography is a technique that induces shear waves in soft tissues through dynamic stress, thereby enabling the assessment of their elasticity by measuring wave velocity. However, limitations in ultrasound imaging, including shadowing, endogenous motion, reverberation, and depth-dependent attenuation, often result in low signal-to-noise ratio (SNR) signals, which present significant challenges for capturing shear waves. To address this issue, we propose a novel shear wave generation method based on acoustic radiation force (ARF) pulses modulated with binary maximum-length sequences (MLS). The method employs a binary-modulated ARF to induce tissue motion, which is then deconvolved with the pulse-coded excitation. The MLS deconvolution results in a broadband impulse response, thereby enabling the recovery of the compressed shear-wave pulse shape over the excitation frequency band and, moreover, enhancing the displacement amplitude and SNR. The initial experimental outcomes indicate that the use of extended coded-excitation ARF pulses results in an SNR gain exceeding 10 dB, attributable to pulse compression. By enhancing the quality of displacement data and reducing noise, the method fortifies the reliability of algorithms utilized to estimate shear wave speed, minimizing the potential for biased outcomes. - Quasi-omnidirectional shear wave generation using acoustic vortices for elastography
Enrique Gonzalez-Mateo, Noe Jimenez, Francisco Camarena
IEEE International Ultrasonics Symposium Ius, 2022
Ultrasound elastography is a reliable tool for medical diagnosis with the aim of finding pathologies that cause tissue stiffness irregularities. Currently, the most used techniques based on acoustic radiation force deform the tissue with a pulse in the direction of beam propagation resulting in linear momentum transfer, producing shear waves in the transverse direction of the beam. In this work we propose using focused acoustic vortices to transfer angular momentum. By twisting the tissue quasi-omnidirectional shear waves can be generated. The goal of this work is to show the first experimental evidence of angular momentum transfer from a vortex to a tissue-mimicking material, and apply this mechanism to improve ultrasound elastography. - Rotating acoustic drills by the interference of detuned vortices
Noe Jimenez, Enrique Gonzalez-Mateo, Francisco Camarena, Kestitis Staliunas
IEEE International Ultrasonics Symposium Ius, 2022
We present acoustic drill beams, structured sound beams exhibiting a dynamic intensity distribution that matches the shape of a helix. The intensity distribution rotates along the beam axis with controlled direction and angular frequency, resembling in this way the shape of a mechanical drill bit. Acoustic drill beams emerge as the spatiotemporal interference of two confocal, detuned vortex beams. The beam parameters are fully tuneable. The detuned frequency, the detuned wavenumber and the detuned topological charge of the composing beams can be tuned to control the drill parameters such as the number of drill arms, the winding period, the rotational speed, and their direction. We show that elongated drill beams are obtained using two confocal high-order Bessel beams, allowing analytical solutions for optimal overlap. In addition, drill beams can also be synthesised using focused ultrasound vortices. Analytical, numerical, and experimental results are shown in the ultrasound regime using a low-cost device based on two 1-MHz confocal piezoelectric transducers and 3D printed acoustic holograms. This exotic structured wavefront opens new avenues for wave-matter interaction, such as contactless particle manipulation, matter processing or biomedical applications. - Synchronized sine-sweep imaging for uncoupling nonlinear signatures during pulse compression
Nathalie Lamothe, Enrique Gonzalez-Mateo, Noe Jimenez, Francisco Camarena
IEEE International Ultrasonics Symposium Ius, 2021
Cavitation mapping is a reliable tool to monitor therapeutic ultrasound applications based in microbubbles. However, when the temporal duration of the transmitted pulses is long, the acoustic emission of the bubbles extends in time, and it becomes difficult to generate sharp acoustic cavitation images. In this work, we present a method based on long synchronized sine-sweep pulses that enable the separation of individual impulse responses to produce sharp cavitation images and increases the signal-to-noise ratio. By uncoupling nonlinear signatures, the method allows the separation of pulse-compressed impulse responses for the linear response and for each harmonic component. In this way, using synchronized sine-sweep, the cavitation of microbubbles under the action of a therapeutic transducer can be mapped with accuracy and with a robust signal-to-noise ratio. This pulse compression method enables the harmonic localization for nonlinear cavitation mapping, enabling the individual imaging of nonlinear signatures of cavitating bubbles. The cavitation images allow to identify the real focal spot of a therapeutic transducer, and the nonlinear signatures offers quantitative information about the stable or inertial regime of the cavitating bubble.
RECENT SCHOLAR PUBLICATIONS
- MLS-Coded ARF Excitation for Noise-Resilient Shear Wave Elastography
E González-Mateo, M Urban, N Jiménez
2025 IEEE International Ultrasonics Symposium (IUS), 1-4 , 2025
2025.0 - A0638–Lithovortex project: Creating new ways for urinary lithotripsy
AJB Romero, B Morant-Ferrando, P Bahilo-Mateu, F Quereda-Flores, ...
European Urology 87, S1463 , 2025
2025.0 - Real-time ultrasound shear wave elastography using a local phase gradient
E González-Mateo, F Camarena, N Jiménez
Computer Methods and Programs in Biomedicine 260, 108529 , 2025
2025.0
Citations: 5 - CAN ACOUSTIC VORTICES FRAGMENT KIDNEY STONES?
S Maldonado-Ortega, E González-Mateo, A Cebrecos, CD Vera-Donoso, ...
2025.0 - Enhanced Real-Time Ultrasound Elastography with Phase Gradient
E González-Mateo, F Camarena, N Jiménez
2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium … , 2024
2024.0 - Shear-Wave Pulse-Compression Elastography using a Modulated Acoustic Radiation Force Excitation
E González-Mateo, J Rodríguez-Sendra, F Camarena, N Jiménez
2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium … , 2024
2024.0 - Improving SNR and Bandwidth of Shear-Wave Displacements Via Modulated Force Excitation
E González-Mateo, F Camarena, N Jiménez
2023.0 - REFLECTORES HELICOIDALES PARA LA FOCALIZACIÓN DE VÓRTICES ACÚSTICOS DE ALTA INTENSIDAD
N Jiménez, E González-Mateo, F Camarena
2023.0 - Midiendo la elasticidad de tejidos biológicos empleando ultrasonidos
E Gonzalez-Mateo, J Rodríguez Sendra, F Camarena Femenia, ...
Sociedad Españ , 2023
2023.0 - Quasi-omnidirectional shear wave generation using acoustic vortices for elastography
E González-Mateo, N Jiménez, F Camarena
2022 IEEE International Ultrasonics Symposium (IUS), 1-4 , 2022
2022.0
Citations: 3 - Rotating acoustic drills by the interference of detuned vortices
N Jiménez, E González-Mateo, F Camarena, K Staliunas
2022 IEEE International Ultrasonics Symposium (IUS), 1-3 , 2022
2022.0 - Synthesizing acoustic drill beams by the superposition of detuned vortices
N Jiménez, E González-Mateo, F Camarena, K Staliunas
The Journal of the Acoustical Society of America 151 (4_Supplement), A121-A121 , 2022
2022.0 - Metamaterial absorbente de alta porosidad para problemas en transmisión
EM González Mateo
Universitat Politècnica de València , 2022
2022.0 - Sharp and nonlinear cavitation mapping using synchronized sine-sweep imaging
E González-Mateo, N Lamothe, N Jiménez, F Camarena
European Congress of Acoustics and Noise Control Engineering, 921-924 , 2021
2021.0 - Synchronized sine-sweep imaging for uncoupling nonlinear signatures during pulse compression
N Lamothe, E González-Mateo, N Jiménez, F Camarena
2021 IEEE International Ultrasonics Symposium (IUS), 1-3 , 2021
2021.0 - VÓRTICES ACÚSTICOS PARA MEDIR LA ELASTICIDAD DE TEJIDOS BIOLÓGICOS
E González-Mateo, F Camarena, N Jiménez - ACOUSTIC DRILL BEAMS: TWISTING WAVE INTENSITY BY THE SUPERPOSITION OF DETUNED VORTICES
N Jiménez, E González-Mateo, F Camarena, K Staliunas - MAPEADO DE LA ELASTICIDAD DE TEJIDOS MEDIANTE UN MÉTODO RÁPIDO BASADO EN GRADIENTE DE FASE
E González-Mateo, N Jiménez, F Camarena - TÉCNICAS DE HOLOGRAFÍA ACÚSTICA PARA LA VALIDACIÓN RÁPIDA DE HOLOGRAMAS ACÚSTICOS
N Jiménez, A Carrión-García, D Andrés, E González-Mateo, ... - Tortuous metamaterial for perfect sound absorption in transmission
E González-Mateo, R Venegas, F Camarena, N Jiménez
MOST CITED SCHOLAR PUBLICATIONS
- Real-time ultrasound shear wave elastography using a local phase gradient
E González-Mateo, F Camarena, N Jiménez
Computer Methods and Programs in Biomedicine 260, 108529 , 2025
2025.0
Citations: 5 - Quasi-omnidirectional shear wave generation using acoustic vortices for elastography
E González-Mateo, N Jiménez, F Camarena
2022 IEEE International Ultrasonics Symposium (IUS), 1-4 , 2022
2022.0
Citations: 3 - MLS-Coded ARF Excitation for Noise-Resilient Shear Wave Elastography
E González-Mateo, M Urban, N Jiménez
2025 IEEE International Ultrasonics Symposium (IUS), 1-4 , 2025
2025.0 - A0638–Lithovortex project: Creating new ways for urinary lithotripsy
AJB Romero, B Morant-Ferrando, P Bahilo-Mateu, F Quereda-Flores, ...
European Urology 87, S1463 , 2025
2025.0 - CAN ACOUSTIC VORTICES FRAGMENT KIDNEY STONES?
S Maldonado-Ortega, E González-Mateo, A Cebrecos, CD Vera-Donoso, ...
2025.0 - Enhanced Real-Time Ultrasound Elastography with Phase Gradient
E González-Mateo, F Camarena, N Jiménez
2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium … , 2024
2024.0 - Shear-Wave Pulse-Compression Elastography using a Modulated Acoustic Radiation Force Excitation
E González-Mateo, J Rodríguez-Sendra, F Camarena, N Jiménez
2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium … , 2024
2024.0 - Improving SNR and Bandwidth of Shear-Wave Displacements Via Modulated Force Excitation
E González-Mateo, F Camarena, N Jiménez
2023.0 - REFLECTORES HELICOIDALES PARA LA FOCALIZACIÓN DE VÓRTICES ACÚSTICOS DE ALTA INTENSIDAD
N Jiménez, E González-Mateo, F Camarena
2023.0 - Midiendo la elasticidad de tejidos biológicos empleando ultrasonidos
E Gonzalez-Mateo, J Rodríguez Sendra, F Camarena Femenia, ...
Sociedad Españ , 2023
2023.0 - Rotating acoustic drills by the interference of detuned vortices
N Jiménez, E González-Mateo, F Camarena, K Staliunas
2022 IEEE International Ultrasonics Symposium (IUS), 1-3 , 2022
2022.0 - Synthesizing acoustic drill beams by the superposition of detuned vortices
N Jiménez, E González-Mateo, F Camarena, K Staliunas
The Journal of the Acoustical Society of America 151 (4_Supplement), A121-A121 , 2022
2022.0 - Metamaterial absorbente de alta porosidad para problemas en transmisión
EM González Mateo
Universitat Politècnica de València , 2022
2022.0 - Sharp and nonlinear cavitation mapping using synchronized sine-sweep imaging
E González-Mateo, N Lamothe, N Jiménez, F Camarena
European Congress of Acoustics and Noise Control Engineering, 921-924 , 2021
2021.0 - Synchronized sine-sweep imaging for uncoupling nonlinear signatures during pulse compression
N Lamothe, E González-Mateo, N Jiménez, F Camarena
2021 IEEE International Ultrasonics Symposium (IUS), 1-3 , 2021
2021.0 - VÓRTICES ACÚSTICOS PARA MEDIR LA ELASTICIDAD DE TEJIDOS BIOLÓGICOS
E González-Mateo, F Camarena, N Jiménez - ACOUSTIC DRILL BEAMS: TWISTING WAVE INTENSITY BY THE SUPERPOSITION OF DETUNED VORTICES
N Jiménez, E González-Mateo, F Camarena, K Staliunas - MAPEADO DE LA ELASTICIDAD DE TEJIDOS MEDIANTE UN MÉTODO RÁPIDO BASADO EN GRADIENTE DE FASE
E González-Mateo, N Jiménez, F Camarena - TÉCNICAS DE HOLOGRAFÍA ACÚSTICA PARA LA VALIDACIÓN RÁPIDA DE HOLOGRAMAS ACÚSTICOS
N Jiménez, A Carrión-García, D Andrés, E González-Mateo, ... - Tortuous metamaterial for perfect sound absorption in transmission
E González-Mateo, R Venegas, F Camarena, N Jiménez