Eniola Risikat Kadir

@unilorin.edu.ng

Senior Assistant Professor, Faculty of Basic Medical Sciences
Senior Assistant Professor, Others
University of Ilorin

Eniola Risikat Kadir


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https://researchid.co/eniolakadir

RESEARCH, TEACHING, or OTHER INTERESTS

Developmental Biology, Endocrinology, Molecular Biology, Obstetrics and Gynecology
9

Scopus Publications

304

Scholar Citations

10

Scholar h-index

11

Scholar i10-index

Scopus Publications

  • A training program improves poor first aid knowledge and skills among primary school teachers in Ibadan, Nigeria
    Abdulmumin Ibrahim, Nadia Adjoa Sam-Agudu, Sadiya Musa Gwadabe, Risikat Eniola Kadir, Boniface Ayanbekongshie Ushie, et al.
    Pan African Medical Journal, 2025
  • Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinson’s disease model
    Fatimo Ajoke Sulaimon, Ruqayyah Yetunde Ibiyeye, Aminu Imam, Aboyeji Lukuman Oyewole, Abubakar Lekan Imam, et al.
    Anatomy and Cell Biology, 2024
    Parkinson’s disease (PD) affects about 8.5 million individuals worldwide. Oxidative and inflammatory cascades are implicated in the neurological sequels, that are mostly unresolved in PD treatments. However, proper nutrition offers one of the most effective and least costly ways to decrease the burden of many diseases and their associated risk factors. Moreover, prevention may be the best response to the progressive nature of PD, thus, the therapeutic novelty of honey and levodopa may be prospective. This study aimed to investigate the neuroprotective role of honey and levodopa against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced oxidative stress. Fifty-four adult male Swiss mice were divided into control and PD model groups of 27 mice. Each third of the control mice either received phosphate buffered saline, honey, or levodopa for 21 days. However, each third of the PD models was either pretreated with honey and levodopa or not pretreated. Behavioral studies and euthanasia were conducted 2 and 8 days after MPTP administration respectively. The result showed that there were significantly (P<0.05) higher motor activities in the PD models pretreated with the honey as well as levodopa. furthermore, the pretreatments protected the midbrain against the chromatolysis and astrogliosis induced by MPTP. The expression of antioxidant markers (glutathione [GSH] and nuclear factor erythroid 2-related factor 2 [Nrf2]) was also significantly upregulated in the pretreated PD models. It is thus concluded that honey and levodopa comparably protected the substantia nigra pars compacta neurons against oxidative stress by modulating the Nrf2 signaling molecule thereby increasing GSH level to prevent MPTP-induced oxidative stress.
  • MORINGA OLEIFERA (MOF6) AND MUSA SAPIENTUM (MSF1) AMELIORATED 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED SKIN HISTO-PATHOLOGY, INFLAMMATION, HEPATIC OXIDATIVE STRESS AND MUTAGENESIS IN RATS
    New Armenian Medical Journal, 2024
  • Morinda lucida and Annona muricata reduced hepatic lipid peroxidation and promoted melatonin/TNFα/p53-mediated apoptosis in sodium arsenite-induced toxicity in rats
    Adelaja Akinlolu, Adeoye Oyewopo, Risikat Kadir, Mubarak Ameen, Victor Owoniyi, et al.
    European Journal of Anatomy, 2022
    Arsenic-induced carcinogenesis can result in cancers of the liver in exposed organisms. This study evaluated anticancer potentials of MLF1 and AMF1 extracted from Morinda lucida and Annona muicata leaves respectively in Sodium arsenite (SA)-induced toxicity in rats. Sixty adult female rats were randomly divided into 12 groups (n = 5). Group 1 was control. Group 2 received 5-weeks administrations of 10 mg/kg bodyweight of SA. Groups 3-6 received SA-dose for 2 weeks followed by 3-weeks posttreatments with MLF1-doses and AMF1-doses respectively. Groups 7-10 received only 5-weeks administrations of MLF1-doses and AMF1- doses respectively. Groups 11 and 12 received 5-weeks co-administrations of SA-dose with highdoses of MLF1 and AMF1 respectively. Drugs/ extracts were administered orally. Liver histopathology (Heamatoxylin and Eosin) and ELISA concentrations of sera Melatonin and TNF-alpha were evaluated. Malondialdehyde (thiobarbituricacid assay) and p53 (ELISA) levels were evaluated in liver homogenates. Data were statistically analysed. Results showed normal liver histology in Groups 1-12. Post-treatments of SA-induced toxicity with MLF1 and AMF1 resulted in significant (P≤0.05) and non-significant decreased levels (P≥0.05) of Malondialdehyde, TNF-alpha and p53, but significant (P≤0.05) and non-significant increased Melatonin levels (P≥0.05) in Groups 3-12 compared with Group 2. MLF1 and AMF1 possess anticancer, antioxidant, pro-Melatonin, anti-inflammatory and hepato-protective potentials.
  • Anticancer potentials of Morinda lucida and Annona muricata on Ki67 and Multidrug resistance1 genes expressions in Sodium arsenite-induced hepato-toxicity in rats
    Adelaja A. Akinlolu, Temitope Omohimoria, Adeoye Oyewopo, Risikat E. Kadir, Mubarak O. Ameen, et al.
    Acta Pharmaceutica Sciencia, 2022
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  • Author’s reply
    Risikat Eniola Kadir, Abdulmumin Ibrahim, Balkis Abimbola Ibrahim, Sadiya Musa Gwadabe, Rukayat Sulaiman-Jaji, et al.
    International Journal of Reproductive Biomedicine, 2021
    This is a Reply Letter and does not have an abstract. Please download the PDF or view the article HTML.
  • Low dose bitter leaf improves sperm quality disrupted in immunosuppressed wistar rats: An experimental study
    Risikat Eniola Kadir, Abdulmumin Ibrahim, Balkis Abimbola Ibrahim, Sadiya Musa Gwadabe, Rukayat Jaji-Sulaimon, et al.
    International Journal of Reproductive Biomedicine, 2020
    Background: Synthetic prednisolone (PRED) is a widely used over-the-counter glucocorticoid. Glucocorticoids have inhibitory effects on the immune system and are often used as immunosuppressive agents. Suppressed immunity may impact fertility via the hypothalamic-pituitary-adrenal axis. Bitter leaf (BL) has been shown to improve sperm parameters, but its effects on immunosuppression-associated infertility have not yet been documented.&#x0D; Objective: To determine the fertility effects of bitter leaf on immunosuppressed Wistar rats.&#x0D; Materials and Methods: A total of 30 male adult Wistar rats were randomly assigned to 6 groups (n = 5/each). Group A served as a control and were given distilled water in addition to normal feeds, group B received 2 mg/kg PRED for 14 days and served as the standard immunosuppressed group, and groups C-F were immunosuppressed as in B but in addition received 50 mg/kg levamisole, low-dose (250 mg/kg) BL, highdose (375 mg/kg) BL, and low-dose BL + levamisole, respectively. The CD4 counts, hematological parameters, and sperm parameters were analyzed and compared.&#x0D; Results: There were significant decreases in sperm motility, progressive motility, morphology, and life/death ratio in the animals given PRED only compared to the controls (p = 0.002, 0.001, 0.001, and 0.01, respectively). These were significantly increased in the treated groups, and animals given levamisole and 250 mg/kg BL showed significantly increased sperm counts compared to the controls (p = 0.04 and p = 0.04, respectively).&#x0D; Conclusion: Low-dose BL (250 mg/kg) restored the sperm parameters altered by prednisolone administration.&#x0D; Key words: Bitter leaf, Immunosuppression, Infertility, Prednisolone, Rats.
  • Prenatal exposure to gestational nicotine before neurulation is detrimental to neurodevelopment of wistar rats’ offspring
    Gabriel Olaiya Omotoso, Risikat Eniola Kadir, Fatima A. Sulaimon, Rukayat Jaji-Sulaimon, Ismail Temitayo Gbadamosi, et al.
    Malaysian Journal of Medical Sciences, 2018
    Background and aim This study aimed to determine the effect of gestational nicotine exposure before neurodevelopment on the morphology and histology of the prefrontal cortex (PFC) in rats. Methodology Adult female Wistar rats were time-mated and grouped into three categories: (a) control–given 0.1 mL of normal saline, (b) low-dose nicotine–given 6.88 mg/ kg/d/0.05 mL, and (c) high-dose nicotine–given 13.76 mg/kg/d/0.1 mL in two divided doses. Treatment was given intraperitoneally from gestational days 2 to 6. On postnatal day 15 (P15), the pups were separated from their mothers, anaesthetised and sacrificed, followed by intracardial perfusion with 4% paraformaldehyde. PFC was excised from the brain and processed for tissue histology, histochemistry, and morphology of brain cells. Results Gestational nicotine exposure during the first week of gestation in rats significantly reduced birth weights in nicotine-treated groups compared with control; it, however, accelerated body weights, altered neuronal morphology, and elevated astrocytic count significantly, while oligodendroglial count was slightly increased in the PFC of juvenile rats examined at P15. Conclusion These alterations revealed that gestational nicotine exposure before the commencement of the cellular processes involved in brain development negatively affects neurodevelopment, and this could result in neurological dysfunctions in later life.
  • Histoenzymic effects of cigarette smoke on the superior colliculus of rattus norvegicus
    G. Omotoso, O. Akinola, E. A. Caxton-martins, R. Kadir, A. Akinyinka
    Internet Journal of Toxicology, 2010
    The study was conducted using twenty adult Wistar rats that were randomly grouped into a treatment and a control group comprising both sexes. The control group was exposed to smoke from cotton wool, while the treatment group inhaled smoke from a completely burnt cigarette containing 0.735 g tobacco, once daily for 14 days. The rats were sacrificed by cervical dislocation and the superior colliculi (SC) excised, weighed, homogenized and assayed for the activities of lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G6PDH), and alkaline phosphatase (ALP). SC tissues for histological studies were fixed in formol calcium and subsequently processed using Feulgen reaction for nucleic acids and Cresyl violet stain for Nissl bodies studies. There was an increase in the enzyme activities in the treated group, compared to the control; and this increase was more in the female rats although not statistically significant. The derangements observed in the enzyme studies led to various histoarchitectural changes in the SC of the rats exposed to tobacco smoke, and a gradual depletion of DNA positive cells and Nissl bodies in the neurons.

RECENT SCHOLAR PUBLICATIONS

  • The Overlooked Link between Adolescent Menstrual Health and School Attendance: A Call for Integrated Reproductive Health Education in Nigerian Schools
    R Kadir, GS Musa
    Shiraz University of Medical Sciences , 2026
    2026
  • The Overlooked Link between Adolescent Menstrual Health and School Attendance: A Call for Integrated Reproductive Health Education in Nigerian Schools
    RO Mohammed-Nasir, ER Kadir, SM Gwadabe
    International Journal of School Health 13 (1), 83-84 , 2026
    2026
  • Vernonia Amygdalina restores prednisolone-induced damage to hypothalamic pituitary testicular axis in male wistar rats
    ER Kadir, AD Yakub, WA El-Hussein, EO Oluwafemi, AT Abdulmaliq, ...
    Tissue and Cell 96, 103022 , 2025
    2025
  • Postpartum Pubic Symphysis Diastasis Following Vaginal Delivery: A Case Report
    RO Mohammed-Nasir, ER Kadir
    International Journal of Health Sciences (Egypt) , 2025
    2025
  • Evaluating the hypoglycaemic, anti-inflammatory, and antioxidant effects of Hibiscus sabdariffa in alloxan-induced diabetic rats
    LS Ojulari, NS Njinga, RA Ganiyu, TO Ayinde, ER Kadir
    Bulletin of Medical and Biological Research 1 (7), 33-42 , 2025
    2025
  • A training program improves poor first aid knowledge and skills among primary school teachers in Ibadan, Nigeria
    A Ibrahim, NA Sam-Agudu, SM Gwadabe, RE Kadir, BA Ushie, ...
    The Pan African Medical Journal 50, 58 , 2025
    2025
    Citations: 1
  • Dominant Traits of the Cheek and Tongue in North Central Nigeria
    ER Kadir, AD Yakub, TM Obe, GN Bada, A Imam, GO Omotoso
    Anatomical Society of Nigeria , 2025
    2025
  • Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1 …
    FA Sulaimon, RY Ibiyeye, A Imam, AL Oyewole, AL Imam, M Shehu, ...
    Anatomy & cell biology 57 (3), 431-445 , 2024
    2024
    Citations: 3
  • Cytoarchitectural differences in reproductive organs of some polycystic ovary-like induced animal models
    ER Kadir, AD Yakub, LS Ojulari, AO Hussein, IA Lawal, R Jaji-Sulaimon, ...
    Tissue and Cell 89, 102456 , 2024
    2024
    Citations: 3
  • Mammographic outcomes among women attending a large imaging facility in Ilorin, Nigeria: a retrospective chart review
    A Ibrahim, AO Olagunju, MK Abdulkadir, K Mpolokeng, KO Mashood, ...
    PAMJ Clinical Medicine 15 (7) , 2024
    2024
  • Exposure to Bisphenol-A and Melatonin altered the Expression of Estrogen and Androgen Receptors in Neonatal Female rats
    ER Kadir
    2024
  • MORINGA OLEIFERA (MOF6) AND MUSA SAPIENTUM (MSF1) AMELIORATED 7, 12-DIMETHYLBENZ [A] ANTHRACENE-INDUCED SKIN HISTO-PATHOLOGY, INFLAMMATION, HEPATIC OXIDATIVE STRESS AND …
    B FAGBOHUNKA, A AKINLOLU, M AMEEN, R KADIR, A OYEWOPO, ...
    New Armenian Medical Journal 18 (1) , 2024
    2024
  • Connective Tissue
    AA Akinlolu, AIR Abioye, ER Kadir, OK Ghazal, FS Lewu
    Department of Anatomy, Kwara State University. , 2024
    2024
  • Reproductive System and Perineum
    ER Kadir, AO Oyewopo, AS Alabi
    Department of Anatomy, University of Ilorin. , 2024
    2024
  • Urinary System
    AL Imam, SB Kareem, ER Kadir, AO Oyewopo
    Department of Anatomy, University of Ilorin. , 2024
    2024
  • Restorative Effects of Melatonin on Bisphenol A-induced Interference of Gene Expression in Hypothalamic Pituitary Axis Following Early Exposure
    ER Kadir, AD Yakub, A Imam, OJ Olajide, IA Lawal, AL Oyewole, ...
    International Journal of Health Sciences 8 (S1), 1293-1315 , 2024
    2024
    Citations: 1
  • ANTI-TOXIC PRINCIPLES FROM MUSA SAPIENTUM AND MORINGA OLEIFERA AMELIORATED SKIN HISTO-PATHOLOGY, DECREASED LIPID PEROXIDATION AND PROMOTED MELATONIN/TNF-ALPHA/P53-MEDIATED …
    A Akinlolu, MO Ameen, AO Oyewopo, RE Kadir, P Nwogu, M Saad, ...
    Malaysian Journal of Pharmaceutical Sciences 22 (1), 43-59 , 2024
    2024
  • Honey and levodopa comparably prevented oxidative damage by modulating ROS-Nrf2-GSH pathway in MPTP-induced Parkinson's disease
    FA SULAIMON, RY Ibiyeye, A Imam, AL Oyewole, AL Imam, M Shehu, ...
    Available at SSRN 4706081 , 2024
    2024
    Citations: 2
  • Handgrip strength as a screening tool for diabetes in resource-constrained settings: a potential solution to overcome barriers to diagnosis
    LS Ojulari, SE Sulaiman, TO Ayinde, ER Kadir
    medRxiv, 2023.10. 19.23297260 , 2023
    2023
    Citations: 3
  • Role of Pituitary Gland in Fertility Preservation
    ER Kadir, AO Hussein, LS Ojulari, GO Omotoso
    IntechOpen , 2023
    2023

MOST CITED SCHOLAR PUBLICATIONS

  • A new model for alloxan-induced diabetes mellitus in rats
    OL Sheriff, O Olayemi, AO Taofeeq, KE Riskat, DE Ojochebo, ...
    Journal of Bangladesh society of physiologist 14 (2), 56-62 , 2019
    2019
    Citations: 47
  • Midline diastema amongst south-western Nigerians
    G Omotoso, E Kadir
    Internet J Dent Sci 8, 1-5 , 2009
    2009
    Citations: 41
  • Effects of aqueous extract of Allium sativum (garlic) on semen parameters in Wistar rats
    G Omotoso, A Oyewopo, R Kadir, S Olawuyi, A Jimoh
    Internet J Urol 7 (2), 1-5 , 2010
    2010
    Citations: 33
  • Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamo-pituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats
    ER Kadir, A Imam, OJ Olajide, MS Ajao
    Anatomy & cell biology 54 (2), 212-224 , 2021
    2021
    Citations: 18
  • Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
    GO Omotoso, RE Kadir, SF Lewu, IT Gbadamosi, AA Akinlolu, ...
    Research journal of health sciences 6 (1), 13-25 , 2018
    2018
    Citations: 18
  • Effects of monosodium glutamate on semen quality and the cytoarchitecture of the testis of adult Wistar rats
    RE Kadir, GO Omotoso, TJ Balogun, AO Oyewopo
    International Journal of Biochemical and Health Sciences 7 (1) , 2011
    2011
    Citations: 18
  • Moringa oleifera and Musa sapientum ameliorated 7, 12-Dimethylbenz [a] anthracene-induced upregulations of Ki67 and multidrug resistance 1 genes in rats
    AA Akinlolu, AO Oyewopo, RE Kadir, A Lawal, J Ademiloye, A Jubril, ...
    International journal of health sciences 15 (3), 26 , 2021
    2021
    Citations: 17
  • Lipid profile and liver histochemistry in animal models exposed to cigarette smoke
    GO Omotoso, BU Enaibe, OB Akinola, RE Kadir, AA Akinlolu, ...
    Journal of Basic & Applied Sciences 8 (1), 12-17 , 2012
    2012
    Citations: 14
  • Testiculo-protective effect of stem bark extract of Enantia chlorantha on lead induced toxicity in adult Wistar rat (Rattus norvergicus)
    AO Oyewopo, LC Saalu, BJ Dare, CI Oyewopo, AA Jimoh, OE Yama, ...
    Reprod. Syst. Sexual Disord 1 (2), 3 , 2012
    2012
    Citations: 12
  • Exposure to cigarette smoke altered the cytoarchitecture and anti-oxidant activity of the frontal cortex in Wistar rats
    GO Omotoso, RE Kadir, JT Alabi, AS Alabi, AO Oyabambi
    International Journal of Biological and Chemical Sciences 7 (4), 1595-1601 , 2013
    2013
    Citations: 11
  • Cephalometric study of mouth morphology among major Nigerian tribes
    AA Akinlolu, RE Akinola, B.Oluwole, Nurudeen R.L., Kadir, A M. S
    Anatomy Journal of Africa 4 (1), 496 - 504 , 2015
    2015
    Citations: 10
  • Prenatal exposure to gestational nicotine before neurulation is detrimental to neurodevelopment of Wistar rats’ offspring
    GO Omotoso, RE Kadir, FA Sulaimon, R Jaji-Sulaimon, IT Gbadamosi
    The Malaysian Journal of Medical Sciences: MJMS 25 (5), 35 , 2018
    2018
    Citations: 9
  • Anticancer effects of Morinda lucida and Annona muricata on immunomodulations of Melatonin, tumor necrosis factor-alpha and p53 concentrations in lead acetate-induced toxicity …
    AA Akinlolu, MO Ameen, AO Oyewopo, RE Kadir, O Ahialaka, S Tijani, ...
    International Journal of Health Sciences 15 (4), 20 , 2021
    2021
    Citations: 8
  • Low dose bitter leaf improves sperm quality disrupted in immunosuppressed Wistar rats: An experimental study
    RE Kadir, A Ibrahim, BA Ibrahim, SM Gwadabe, R Jaji-Sulaimon, ...
    International Journal of Reproductive Biomedicine 18 (3), 215 , 2020
    2020
    Citations: 6
  • Testicular Morphology and Seminal fluid parameters of adult Wistar rats following honey administration
    RE Kadir, LS Ojulari, A Ibrahim, E Oluwole J., R Jaji-Sulaimon, ...
    Tropical Journal of Pharmaceutical Research 17 (7), 1331 - 1335 , 2018
    2018
    Citations: 4
  • Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1 …
    FA Sulaimon, RY Ibiyeye, A Imam, AL Oyewole, AL Imam, M Shehu, ...
    Anatomy & cell biology 57 (3), 431-445 , 2024
    2024
    Citations: 3
  • Cytoarchitectural differences in reproductive organs of some polycystic ovary-like induced animal models
    ER Kadir, AD Yakub, LS Ojulari, AO Hussein, IA Lawal, R Jaji-Sulaimon, ...
    Tissue and Cell 89, 102456 , 2024
    2024
    Citations: 3
  • Handgrip strength as a screening tool for diabetes in resource-constrained settings: a potential solution to overcome barriers to diagnosis
    LS Ojulari, SE Sulaiman, TO Ayinde, ER Kadir
    medRxiv, 2023.10. 19.23297260 , 2023
    2023
    Citations: 3
  • Altered Testicular Histomorphometric and Antioxidant Levels Fol-lowing In vivo Bisphenol-A Administration
    ER Kadir, LS Ojulari, TA Gegele, IA Lawal, L Sulu-Gambari, FA Sulaimon
    Iranian journal of toxicology 15 (3), 165-174 , 2021
    2021
    Citations: 3
  • Haematological effects of aqueous extract of Vernonia amygdalina and a known immunostimulant in Wistar rats
    RE Kadir, A Ibrahim, IM Bamtefa, BA Ibrahim, MK Ogunfemi, SM Gwadabe, ...
    EDITORIAL BOARD, 3447 , 2018
    2018
    Citations: 3