Eman Abdelmonem Elshenawy

Scopus Publications

Stability indicating RP-HPLC method for estimation of finerenone and its related substances in new dosage form
Aya A. Marie, Mohamed G. Yassin, Eman A. Elshenawy
Scientific Reports, 2025
Stability indicating RP-HPLC method was developed and validated for the estimation of finerenone (FIN) in pure and in new tablet dosage form. The proposed approach was applied and validated for determination of (FIN) related substances. Stability studies of (FIN) was carried out using five stress conditions; acid, alkali, oxidation, photodegradation and heat degradation. The chromatographic analysis of (FIN) was based on using mobile phase consist of filtered and degassed mixture of 450mL water, 550mL acetonitrile and 10mL triethylamine with pH adjusted to 7. Phenomenex (C18, 4.6 × 250 mm, 5 μm) column was used with 0.8 mL/min flow rate and 40 °C column temperature. The UV detection was set at 252 nm with injection volume (10µL). The (FIN) retention time was 4.437 ± 0.05 min. The proposed technique was validated according to ICH guidelines with good linearity in ranges (8–30 µg/mL) for assay of (FIN) and (0.2–1.4 µg/mL) for determination of (FIN) unspecified impurities. The found mean percentage recoveries were 99.74% for (FIN) assay and 99.11% for (FIN) related substance determination which indicate good trueness. The developed approach was successfully applied for the determination of (FIN) in Nexifinerenone® film coated tablet dosage form. Good agreement was established when assay results using the validated RP-HPLC method were compared statistically to those obtained using the reported method. For the greenness assessment Complex GAPI, Complex MoGAPI and AGREE methods were applied.
Sustainable synthesis of Cu-doped carbon dots from biomass waste for sensitive molnupiravir analysis in pharmaceutical capsules
Eman A. Elshenawy, Fotouh R. Mansour
Microchemical Journal, 2025
A spatial hue smartphone-based colorimetric detection and discrimination of carmine and carminic acid in food products based on differential adsorptivity
Aya A. Abdella, Eman A. Elshenawy
Talanta, 2025
Unlocking the potential of eggplant peel: Powerful peroxidase nanozyme for l-cysteine determination in pharmaceutical supplements
Eman A. Elshenawy, Moataz A. Shaldam
Microchemical Journal, 2024
P-doped carbon dot nano-probe for inner filter effect–based determination of sarecycline in pharmaceutical dosage form and human plasma
Eman A. Elshenawy, Mohamed G. Yassin, Aya A. Marie
Luminescence, 2024
Based on novel phosphorus‐doped carbon dots (PCDs), a simple, quick, and accurate fluorescence probe for sarecycline (SAR) determination has been created. The PCDs were prepared in just five minutes using green, straightforward one‐step microwave pyrolysis. To create the PCD probe, sodium phosphate monobasic was utilized as a phosphorus dopant and citric acid as a carbon supply. The proposed synthesis method was energy efficient and yielded CDs with a narrow particle size distribution. Based on inner‐filter effect mechanism, the generated PCDs were used as nano‐probe for SAR determination. The fluorescence quenching intensity showed a strong linear relationship with SAR concentration in the 3–90‐μM range with a detection limit of 0.88 μM. Because there is no surface alteration of the CDs or creation of a covalent bond between SAR and PCDs, the developed approach is quick, easy, inexpensive, and requires less time. The new probe's enhanced sensitivity, broad linear range, and acceptable selectivity made it suitable for SAR measurement in pharmaceutical formulations and spiked human plasma. Most importantly, the Green Analytical Procedure Index (GAPI) and Analytical GREEnness (AGREE) assessments showed that the suggested method was environmentally friendly.
Green microwave-prepared N and S Co-doped carbon dots as a new fluorescent nano-probe for tilmicosin detection
Eman A. Elshenawy, Samah F. El-Malla, Sherin F. Hammad, Fotouh R. Mansour
Talanta, 2023
Innovative spectrofluorimetric determination of vildagliptin based on a “switch off/on” NS-doped carbon dot nanosensor
Eman A. Elshenawy, Samah F. El-Malla, Sherin F. Hammad, Fotouh R. Mansour
Rsc Advances, 2022
Microwave synthesis of a switchable sensor as a label-free recognition system for VLD determination. The sensor was applied for VLD determination in dosage form and human urine.
Rapid microwave synthesis of N,S-doped carbon quantum dots as a novel turn off-on sensor for label-free determination of copper and etidronate disodium
Samah F. El-Malla, Eman A. Elshenawy, Sherin F. Hammad, Fotouh R. Mansour
Analytica Chimica Acta, 2022
N-Doped Carbon Dots as a Fluorescent Nanosensor for Determination of Colchicine Based on Inner Filter Effect
Samah F. El-Malla, Eman A. Elshenawy, Sherin F. Hammad, Fotouh R. Mansour
Journal of Fluorescence, 2021
Green micellar HPLC-fluorescence method for simultaneous determination of metoprolol and amlodipine in their combined dosage form: Application on metoprolol in spiked human plasma
Mokhtar M. Mabrouk, Sherin F. Hammad, Samah F. El-Malla, Eman A. Elshenawy
Microchemical Journal, 2019
Simultaneous determination of amlodipine and metoprolol in their combined dosage form using a synchronous fluorescence spectrofluorimetric method
Mokhtar M. Mabrouk, Sherin F. Hammad, Samah F. El-Malla, Eman A. Elshenawy
Luminescence, 2018

Eman Abdelmonem Elshenawy

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Scopus Publications