A randomized prospective study of neonatal hepatitis B vaccine immunogenicity in The Gambia and Papua New Guinea Joann Diray-Arce, Caitlin Syphurs, Annmarie Hoch, Kerry McEnaney, Kinga K. Smolen, Oghenebrume Wariri, Abdulazeez Imam, Tida Dibassey, Fatoumata Cole, Fatoumatta Ceesay, Alansana Darboe, William S. Pomat, Rebecca Ford, Geraldine Masiria, Dorcas Joseph, Joe Jude, Rym Ben-Othman, Casey P. Shannon, Sanya Thomas, Geert Leroux-Roels, Frédéric Clement, Gwenn Waerlop, Caitlyn McLoughlin, Sofia M. Vignolo, Shun Rao, Nelly Amenyogbe, Nelly Amenyogbe, Asimenia Angelidou, Winnie Bao, Rym Ben-Othman, Tue B. Bennike, Travis M. Blimke, Morten Bjerregaard-Andersen, Ryan R. Brinkman, Byron Brook, Kendyll Burnell, Bing Cai, Abhinav Checkervarty, Jing Chen, Virginia Chen, Mitchell Cooney, Momoudou Cox, Alansana Darboe, Bhavjinder K. Dhillon, Tida Dibassey, Joann Diray-Arce, Reza Falsafi, Benoit Fatou, Rebecca Ford, Freddy Francis, Christian N. Golding, Robert E.W. Hancock, Danny J. Harbeson, Daniel He, Samuel H. Hinshaw, Annmarie Hoch, Joe Huang, Olubukola T. Idoko, Abdulazeez Imam, Beate Kampmann, Meagan Karoly, Wendy Kirarock, Tobias R. Kollmann, Ken Kraft, Kristina Lindberg Larsen, Jessica Lasky-Su, Amy H. Lee, Ofer Levy, Aaron Liu, Mark Liu, Mehrnoush Malek, Arnaud Marchant, Geraldine Masiria, David Jim, John Paul Matlam, Kerry McEnaney, Caitlyn McLoughlin, Sebastiano Montante, Elena Morrocchi, Jorjoh Ndure, Athena Nguyen, Jainaba Njie-Jobe, Oludare A. Odumade, Al Ozonoff, Jensen Pak, Paolo Palma, Edward P.K. Parker, Matthew A. Pettengill, Alec Plotkin, William S. Pomat, Shun Rao, Peter C. Richmond, Elishia Roberts, Gerard Saleu, Lilica Sanca, Guzman Sanchez-Schmitz, Frederik Schaltz-Buchholzer, Casey P. Shannon, Amrit Singh, Maren Smith, Kinga K. Smolen, Hanno Steen, Julia Strandmark, Caitlin Syphurs, Scott J. Tebbutt, Anita H.J. van den Biggelaar, Simon D. van Haren, Natallia Varankovich, Sofia M. Vignolo, Diana Vo, Oghenebrume Wariri, Oludare Odumade, Asimenia Angelidou, Scott J. Tebbutt, Arnaud Marchant, Tobias R. Kollmann, Ofer Levy, Peter C. Richmond, Anita H.J. van den Biggelaar, Beate Kampmann, Olubukola T. Idoko, Al Ozonoff Journal of Allergy and Clinical Immunology Global, 2026 Background: Protection of newborns from infection can be achieved through maternal or vaccine-induced antibodies, but the factors influencing vaccine protection (correlate of protection) and subsequent infant immunity remain insufficiently understood. Further investigation is essential to optimize early-life vaccination strategies. Objective: We sought to evaluate the impact of timing and sequence of hepatitis B vaccine (HBV) and Bacille Calmette-Guérin (BCG) vaccine within the first week of life on infant HBV immunogenicity and its relationship with maternal antibodies. Methods: This was an exploratory analysis of a US National Institutes of Health-supported prospective, randomized study of systems biology signatures predictive of HBV immunogenicity in 2 geographically distinct cohorts in The Gambia (GAM; N = 720) and Papua New Guinea (PNG, N = 101) (clinicaltrials.gov NCT03246230). Healthy, hepatitis B surface antigen (anti-HBs)-negative mothers and their infants were enrolled and randomized into 4 vaccine groups: HBV alone, BCG alone, HBV + BCG, or no vaccination (delayed until no later than day of life [DOL]7). Blood samples were collected at birth (DOL0) and on a randomly assigned day (either DOL1, DOL3, or DOL7) with a maximum of 2 blood draws in the first week of life per ethics approval. All infants received catch-up vaccination within DOL7 and the recommended oral polio vaccine within 10 days of birth. Additional blood samples were collected at DOL30 and DOL128 to measure anti-HBs titers and assess immunogenicity. Results: = .019, respectively). Conclusions: This study demonstrates the feasibility of conducting large-scale neonatal immunogenicity studies in resource-constrained settings. Our observations underscore the importance of vaccine timing and maternal antibodies in shaping early-life vaccine-induced immunogenicity, offering valuable insights for neonatal vaccination schedules.
Higher Promoter Methylation of the Ubiquitin-Associated and SH3 Domain Containing A (UBASH3A) Gene Is Associated With T-Lymphocyte Ontogeny and Reduced Susceptibility to Early-Onset Sepsis Ziyi Wang, Nelly Amenyogbe, Rym Ben-Othman, Bing Cai, Mandy Lo, Olubukola T Idoko, Oludare A Odumade, Reza Falsafi, Travis M Blimkie, Andy An, Casey P Shannon, Sebastiano Montante, Bhavjinder K Dhillon, Joann Diray-Arce, Al Ozonoff, Kinga K Smolen, Ryan R Brinkman, Kerry McEnaney, Asimenia Angelidou, Peter Richmond, Scott J Tebbutt, Beate Kampmann, Robert E W Hancock, Amy H Y Lee, Ofer Levy, Tobias R Kollmann, David Martino Journal of Infectious Diseases, 2026 We investigated the genetic and epigenetic regulation of the UBASH3A gene and its association with early-onset sepsis. Using matched whole blood DNA methylation, gene expression, genotypes, and immune cell counts from the EPIC-HIPC newborn cohort, we report that promoter methylation was negatively correlated (Pearson r = −0.5, P < 2.2 × 10−16) with ontogenetic changes in UBASH3A gene expression and circulating CD3+ T-cell numbers. Higher promoter methylation at birth was associated with lower UBASH3A expression and reduced early-onset sepsis risk (odds ratio, 0.26; P = .015). Genetic variation significantly influenced variations in baseline UBASH3A methylation (132 cis-meQTL, false discovery rate <0.05).
Pre-vaccination immune signatures of children with inborn errors of immunity associate with COVID-19 vaccine response Paolo Palma, Elena Emili, Chiara Pighi, Nicole Colantoni, Elena Morrocchi, Giuseppe Rubens Pascucci, Beatrice Rivalta, Gioacchino Andrea Rotulo, Chiara Rossetti, Veronica Santilli, Paola Zangari, Emma Concetta Manno, Marco Sanna, Andrea Finocchi, Caterina Cancrini, Maria Pia Cicalese, Sabina Cenciarelli, Emilia Cirillo, Giuliana Giardino, Viviana Moschese, Donato Amodio, Nicola Cotugno Human Vaccines and Immunotherapeutics, 2026 = .014). Transcriptional profiling revealed 41 differentially expressed genes between groups at baseline. Activated memory B cells and peripheral T follicular helper cells from high responders exhibited greater induction of activation and memory-related genes, including NFKB1, CD69, TIGIT, CD40L, and BATF, indicating greater intrinsic readiness to support coordinated antibody production. These findings demonstrate that distinct pre-vaccination gene expression patterns within specific immune subsets are associated with differential humoral responses to mRNA vaccination in individuals with inborn errors of immunity. More broadly, the study highlights that baseline molecular immune features substantially influence vaccine efficacy and suggests that pre-vaccination transcriptional profiling may enable more personalized vaccination strategies for individuals with impaired immunity.
Innate Lymphoid Cell Phenotypic and Functional Alterations in Patients With Systemic Juvenile Idiopathic Arthritis Linda Quatrini, Cecilia Ciancaglini, Ivan Caiello, Silvia Santopolo, Manuela Pardeo, Valentina Matteo, Elena Loricchio, Donato Amodio, Elena Morrocchi, Giulio Olivieri, Paolo Palma, Antonella Insalaco, Marco Francesco Natale, Arianna De Matteis, Nicola Tumino, Claudia Bracaglia, Paola Vacca, Lorenzo Moretta, Fabrizio De Benedetti, Giusi Prencipe Arthritis and Rheumatology, 2025 ObjectiveSystemic juvenile idiopathic arthritis (sJIA) is a chronic childhood disease classically attributed to innate immune cell dysregulation. This study aimed to elucidate the role of innate lymphoid cells (ILCs), including natural killer (NK) cells and helper‐ILCs (hILCs), in sJIA during clinically inactive disease (CID) through phenotypic and functional analysis.MethodsPeripheral ILCs from children with sJIA during CID receiving interleukin‐1 (IL‐1) inhibitors (n = 40) were analyzed by flow cytometry and compared to 23 healthy children (HC) and 22 patients with unrelated autoinflammatory diseases taking IL‐1 inhibitors. Plasma proteomic profiling was also performed.ResultsPatients with sJIA showed a significant reduction in circulating NK cell frequencies compared to HC, with an increased proportion of CD56bright NK cells. Although overall hILC frequencies were comparable to HC, ILC1s were increased, whereas ILC precursors were reduced. ILC1 frequency correlated positively with IL‐18 plasma levels, whereas ILC2 frequency correlated negatively. Functional assessments revealed that NK cells from patients with sJIA had variable interferon γ (IFNγ) production upon IL‐18/IL‐12 stimulation, inversely correlating with IL‐18 levels. Additionally, hILCs from these patients showed a specific impairment in IFNγ production despite normal IL‐13 production, potentially linked to decreased IL‐18 receptor α expression in ILC1s. Proteomic analysis confirmed IL‐18 as the most up‐regulated cytokine in sJIA plasma.ConclusionPatients with sJIA in CID exhibit significant innate immune abnormalities, including altered ILC subset distribution and impaired IFNγ production, strongly associated with IL‐18 levels. These findings suggest ongoing immune dysregulation despite clinical remission, underscoring a potential role for ILCs and cytokine interaction in sJIA pathogenesis.
Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls Danilo Buonsenso, Nicola Cotugno, Donato Amodio, Giuseppe Rubens Pascucci, Gabriele Di Sante, Chiara Pighi, Elena Morrocchi, Alessandro Pucci, Giulio Olivieri, Nicole Colantoni, Lorenza Romani, Arianna Rotili, Alessia Neri, Rosa Morello, Michela Sali, Adriana Tremoulet, Francesca Raffaelli, Giuseppe Zampino, Paolo Rossi, Piero Valentini, Paolo Palma Pediatric Research, 2025
Distinct viral reservoirs and immune signatures in individuals on long-term antiretroviral therapy with perinatally acquired HIV-1 Benjamin Bone, Nicola Cotugno, Chiara Pighi, Arianna Rotili, Seohyun Hong, Leah Carrere, Elena Morrocchi, Giuseppe Rubens Pascucci, Ce Gao, Nicole Colantoni, Weiwei Sun, Giovanna Leone, David R. Collins, Mpho J. Olatotse, Giovanna Del Principe, Toong Seng Tan, Melanie Lancien, Alessia Neri, Libera Sessa, Giulio Olivieri, Kailey Shapiro, Isabelle Roseto, Catherine Koofhethile, Elena Emili, Stefania Bernardi, Ann Chahroudi, Paolo Rossi, Bruce D. Walker, Xu G. Yu, Mathias Lichterfeld, Paolo Palma Cell Reports Medicine, 2025 T cell response. Collectively, our data suggest that long-term ART initiated in early life following perinatal transmission may facilitate an immune environment better equipped to restrict the HIV-1 reservoir.
Pre-vaccination immune markers predict response to BNT162b2 mRNA vaccine in vulnerable groups – The CONVERS project, report from a pediatric tertiary hospital Nicola Cotugno, Marco Sanna, Donato Amodio, Elena Morrocchi, Chiara Pighi, Chiara Medri, Giuseppe Rubens Pascucci, Veronica Santilli, Emma Concetta Manno, Paola Zangari, Chiara Rossetti, Nicole Colantoni, Giulio Olivieri, Elena Emili, Alessia Neri, Arianna Rotili, Paolo Rossi, Ofer Levy, Lorenza Putignani, Paolo Palma, Lorenza Romani, Andrea Finocchi, Caterina Cancrini, Viviana Moschese, Mayla Sgrulletti, Laura Lancella, Stefania Bernardi, Maia De Luca, Carmela Giancotta, Luna Colagrossi, Francesco Bonfante, Elisa Profeti, Enrica Franzese, Antonino Amodeo, Carlo Federico Perno, Marta Ciofi Degli Atti, Carlo Plebani, Carlo Giaquinto, Diletta Valentini, Alberto Villani, Paola De Angelis, Francesca Rea, Renato Tambucci, Beatrice Rivalta, Lucia Pacillo, Gioacchino Andrea Rotulo Vaccine, 2025 BACKGROUND: Whereas several studies have demonstrated the long-term immunogenicity of BNT162b2 vaccine in healthy adults, little evidence was provided in vulnerable populations (VPs) with generally low ability to respond to immunizations. We aimed to identify pre-vaccination immune phenotype and transcriptional signatures in B and T-cell subsets associated with immune response and long-term maintenance upon SARS-CoV-2 vaccination in VPs. METHODS: A cohort of VPs (N = 169) including solid organ transplant recipients (SOT; N = 35), Inflammatory Bowel Disease (N = 31), Down Syndrome (N = 42), people living with HIV (N = 36), primary immune deficiencies (N = 25) and healthy controls (N = 37) were enrolled in the CONVERS Study. SARS-CoV-2 Vaccine responsiveness was evaluated by SARS-CoV-2-specific Ab and SARS-CoV-2-specific CD4+ T cells in VPs naive to infection or vaccination. Based on the humoral response at T28, individuals were classified as Protected (P: anti-spike antibody [anti-S] titer ≥0.8) and Not-Protected (NP: anti-S titer <0.8). Peripheral blood mononuclear cells, after SARS-CoV-2 Prot-S peptides stimulation were sort-purified in four cell subsets and analyzed by multiplexed RT-PCR (Fluidigm, Biomark). RESULTS: SOT presented a significantly lower serological immunogenicity with 31 % of individuals being NP at T28 whereas only 1 out of the remaining 119 resulted Ab negative at T28. At T0, NP individuals showed a lower increase of Ag specific CD40L+ T cells and lower switched memory B cells compared to P patients. Gene-expression analysis revealed distinct signatures at baseline between P and NP individuals with 63 and 49 DEGs identified in two experimental conditions, respectively unstimulated and stimulated. CONCLUSIONS: Pre-vaccination B and T-cell characteristics at both phenotypic and gene- expression level correlate with short- and long- term memory maintenance in VPs with lower immunogenicity upon BNT162b2 vaccine. Such signatures need to be validated in larger cohorts and may provide a predictive score to inform personalized and more effective vaccine interventions.
Early inflammation as a footprint of increased mortality risk in infants living with HIV from three African countries Elena Morrocchi, Giuseppe R. Pascucci, Nicola Cotugno, Chiara Pighi, Sara Dominguez-Rodriguez, Maria Raffaella Petrara, Alfredo Tagarro, Louise Kuhn, Mark F. Cotton, Kennedy Otwombe, Maria G. Lain, Paula Vaz, Shaun L. Barnabas, Moira J. Spyer, Elisa Lopez, Sheila Fernández-Luis, Tacilta Nhampossa, Almoustapha I. Maiga, Oumar Dolo, Anita De Rossi, Pablo Rojo, Carlo Giaquinto, Mathias Lichterfeld, Avy Violari, Theresa Smit, Osee Behuhuma, Nigel Klein, Lesley De Armas, Savita Pahwa, Paolo Rossi, Paolo Palma, , Paolo Rossi, Silvia Faggion, Daniel Gomez Pena, Inger Lindfors Rossi, Federica D’Ambrosio, Andrea Oletto, Francesca Mazzetto, Musakanya Ching’andu, Alessandra Nardone, William James, Nicola Cotugno, Paola Zangari, Carla Paganin, Paolo Palma, Alfredo Tagarro, Anita De Rossi, Sara Dominguez-Rodriguez, Louise Kuhn, Andrew Yates, Mark F. Cotton, Shaun Barnabas, Avy Violari, Kennedy Otwombe, Paula Vaz, Maria Grazia Lain, Moira Spyer, Eleni Nastouli, Kathleen Gartner, Elisa López, Sheila Fernandez-Luis, Denise Naniche, Tacilta Nhampossa, Almoustapha Maiga, Mariam Sylla, Pablo Rojo, Carlo Giaquinto, Mathias Lichterfeld, Nigel Klein, Carlota Miranda, Savita Pahwa, Anne-Genevieve Marcelin, Vincent Calvez, Caroline Foster, Deborah Persaud, Viviana Giannuzzi, Annalisa Landi, Adriana Ceci, Ofer Levy, Philip Goulder, Holly Peay, Thanyawee Puthanakit, Cissy Kityo Scientific Reports, 2024 In this work our aim was to identify early biomarkers in plasma samples associated with mortality in children with perinatal HIV treated early in life, to potentially inform early intervention targeting this vulnerable group. 20/215 children (9.3%) with perinatal HIV, enrolled within 3 months of age died prematurely within the first year of the study, despite early ART initiation. Using a propensity score, we selected 40 alive study participants having similar clinical and virological records compared to the deceased group. 13 HIV unexposed (HU) healthy children were additionally used as controls. Baseline plasma samples were analyzed using a targeted proteomic approach, and to assess pathogen-associated and damage-associated molecular patterns (PAMPs, DAMPs) levels. Data from deceased participants were compared to both control groups, with multivariate logistic regression models used to evaluate the association between mortality and plasma proteins. We developed a machine learning model to predict mortality risk, finding that IL-6 and CXCL11 not only were higher in deceased children than Matched-children with HIV (p < 0.001 and p = 0.0034) but also predictive of mortality (accuracy of 77%); levels of PAMPs were higher in deceased children (p = 0.0016). Thus, measuring early inflammatory biomarkers, particularly IL-6, could help mortality risk prediction and potentially guide targeted interventions.
Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation Andy Y. An, Erica Acton, Olubukola T. Idoko, Casey P. Shannon, Travis M. Blimkie, Reza Falsafi, Oghenebrume Wariri, Abdulazeez Imam, Tida Dibbasey, Tue Bjerg Bennike, Kinga K. Smolen, Joann Diray-Arce, Rym Ben-Othman, Sebastiano Montante, Asimenia Angelidou, Oludare A. Odumade, David Martino, Scott J. Tebbutt, Ofer Levy, Hanno Steen, Tobias R. Kollmann, Beate Kampmann, Robert E.W. Hancock, Amy H. Lee, Nelly Amenyogbe, Asimenia Angelidou, Winnie Bao, Rym Ben-Othman, Tue Bennike, Travis Blimkie, Morten Bjerregaard-Andersen, Ryan R. Brinkman, Byron Brook, Kendyll Burnell, Bing Cai, Abhinav Checkervarty, Jing Chen, Virginia Chen, Mitchell Cooney, Momoudou Cox, Alansana Darboe, Bhavjinder K. Dhillon, Tida Dibassey, Joann Diray-Arce, Reza Falsafi, Benoit Fatou, Rebecca Ford, Freddy Francis, Christian N. Golding, Robert E.W. Hancock, Danny J. Harbeson, Daniel He, Samuel H. Hinshaw, Annmarie Hoch, Joe Huang, Olubukola T. Idoko, Abdulazeez Imam, Beate Kampmann, Wendy Kirarock, Tobias R. Kollmann, Meagan E. Karoly, Ken Kraft, Kristina Larsen, Jessica Lasky-Su, Amy H. Lee, Ofer Levy, Aaron Liu, A, Mark Liu, M, Mehrnoush Malek, Arnaud Marchant, Geraldine Masiria, David Jim Martino, John Paul Matlam, Kerry McEnaney, Caitlyn McLoughlin, Sebastiano Montante, Elena Morrocchi, Jorjoh Ndure, Athena Nguyen, Jainaba Njie-Jobe, Oludare A. Odumade, Al Ozonoff, Jensen Pak, Paolo Palma, Edward P.K. Parker, Matthew A. Pettengill, Alec Plotkin, William S. Pomat, Shun Rao, Peter C. Richmond, Elishia Roberts, Gerard Saleu, Lilica Sanca, Guzman Sanchez-Schmitz, Frederik Schaltz-Buchholzer, Casey P. Shannon, Amrit Singh, Maren Smith, Kinga K. Smolen, Hanno Steen, Julia Strandmark, Caitlin Syphurs, Scott J. Tebbutt, Anita H.J. van den Biggelaar, Simon D. van Haren, Natallia Varankovich, Sofia Vignolo, Diana Vo, Oghenebrume Wariri Ebiomedicine, 2024 BACKGROUND: Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There remains a need for early biomarkers to facilitate timely intervention. Our objective was to identify neonatal sepsis gene expression biomarkers that could predict sepsis at birth, prior to clinical presentation. METHODS: Among 720 initially healthy full-term neonates in two hospitals (The Gambia, West Africa), we identified 21 newborns who were later hospitalized for sepsis in the first 28 days of life, split into early-onset sepsis (EOS, onset ≤7 days of life) and late-onset sepsis (LOS, onset 8-28 days of life), 12 neonates later hospitalized for localized infection without evidence of systemic involvement, and 33 matched control neonates who remained healthy. RNA-seq was performed on peripheral blood collected at birth when all neonates were healthy and also within the first week of life to identify differentially expressed genes (DEGs). Machine learning methods (sPLS-DA, LASSO) identified genes expressed at birth that predicted onset of neonatal sepsis at a later time. FINDINGS: Neonates who later developed EOS already had ∼1000 DEGs at birth when compared to control neonates or those who later developed a localized infection or LOS. Based on these DEGs, a 4-gene signature (HSPH1, BORA, NCAPG2, PRIM1) for predicting EOS at birth was developed (training AUC = 0.94, sensitivity = 0.93, specificity = 0.92) and validated in an external cohort (validation AUC = 0.72, sensitivity = 0.83, and specificity = 0.83). Additionally, during the first week of life, EOS disrupted expression of >1800 genes including those influencing immune and metabolic transitions observed in healthy controls. INTERPRETATION: Despite appearing healthy at birth, neonates who later developed EOS already had distinct whole blood gene expression changes at birth, which enabled the development of a 4-gene predictive signature for EOS. This could facilitate early recognition and treatment of neonatal sepsis, potentially mitigating its long-term sequelae. FUNDING: CIHR and NIH/NIAID.
The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo Byron Brook, Abhinav Kumar Checkervarty, Soumik Barman, Cali Sweitzer, Anna-Nicole Bosco, Amy C. Sherman, Lindsey R. Baden, Elena Morrocchi, Guzman Sanchez-Schmitz, Paolo Palma, Etsuro Nanishi, Timothy R. O’Meara, Marisa E. McGrath, Matthew B. Frieman, Dheeraj Soni, Simon D. van Haren, Al Ozonoff, Joann Diray-Arce, Hanno Steen, David J. Dowling, Ofer Levy Iscience, 2024 mRNA vaccines demonstrate impaired immunogenicity and durability in vulnerable older populations. We hypothesized that human in vitro modeling and proteomics could elucidate age-specific mRNA vaccine actions. BNT162b2-stimulation changed the plasma proteome of blood samples from young (18-50Y) and older adult (≥60Y) participants, assessed by mass spectrometry, proximity extension assay, and multiplex. Young adult up-regulation (e.g., PSMC6, CPN1) contrasted reduced induction in older adults (e.g., TPM4, APOF, APOC2, CPN1, PI16). 30–85% lower T H 1-polarizing cytokines and chemokines were induced in elderly blood (e.g., IFNγ, CXCL10). Analytes lower in older adult samples included human in vivo mRNA immunogenicity biomarkers (e.g., IFNγ, CXCL10, CCL4, IL-1RA). BNT162b2 also demonstrated reduced CD4 + T H 1 responses in aged vs. young adult mice. Our study demonstrates the utility of human in vitro platforms modeling age-specific mRNA vaccine immunogenicity, highlights impaired support of T H 1 polarization in older adults, and provides a rationale for precision mRNA vaccine adjuvantation to induce greater immunogenicity.
Multi-modal immune dynamics of pre-COVID-19 Kawasaki Disease following intravenous immunoglobulin Nicola Cotugno, Giulio Olivieri, Giuseppe Rubens Pascucci, Donato Amodio, Elena Morrocchi, Chiara Pighi, Emma Concetta Manno, Gioacchino Andrea Rotulo, Carolina D'Anna, Marcello Chinali, Isabella Tarissi de Jacobis, Danilo Buonsenso, Alberto Villani, Paolo Rossi, Alessandra Marchesi, Paolo Palma Clinical Immunology, 2024
High mortality following early initiation of antiretroviral therapy in infants living with HIV from three African countries Alfredo Tagarro, Sara Domínguez-Rodríguez, Mark Cotton, Kennedy Otwombe, Nigel Klein, Maria Grazia Lain, Tacilta Nhampossa, Almoustapha Issiaka Maiga, Shaun Barnabas, Paula Vaz, Avy Violari, Sheila Fernández-Luis, Osee Behuhuma, Mariam Sylla, Elisa López-Varela, Denise Naniche, Anita Janse-Van-Rensburg, Afaaf Liberty, Nastassja Ramsagar, Theresa Smit, Senamile Makhari, Nalia Ismael, Carlo Giaquinto, Paolo Rossi, Louise Kuhn, Paolo Palma, Moira Spyer, Mathias Lichterfeld, Eleni Nastuoli, Viviana Giannuzzi, Alvaro Ballesteros, Nicola Cotugno, Elena Morrocchi, Andrea Oletto, Fatoumata Tata Traoré, Els Dobbels, Yasmeen Akhalwaya, Gregory Ording-Jespersen, Caroline Foster, Helena Rabie, Pauline Amuge, Camille Brehin, Savita Pahwa, Yacouba Aba Coulibaly, Pablo Rojo Eclinicalmedicine, 2024
Children with perinatally acquired HIV exhibit distinct immune responses to 4CMenB vaccine Nicola Cotugno, Alessia Neri, Marco Sanna, Veronica Santilli, Emma Concetta Manno, Giuseppe Rubens Pascucci, Elena Morrocchi, Donato Amodio, Alessandra Ruggiero, Marta Luisa Ciofi degl Atti, Irene Barneschi, Silvia Grappi, Ilaria Cocchi, Vania Giacomet, Daria Trabattoni, Giulio Olivieri, Stefania Bernardi, Daniel O’Connor, Emanuele Montomoli, Andrew J. Pollard, Paolo Palma Jci Insight, 2024
Effective early antiretroviral therapy in perinatal-HIV infection reduces subsequent plasma inflammatory profile Athena N. Nguyen, Alec L. Plotkin, Oludare A. Odumade, Lesley De Armas, Savita Pahwa, Elena Morrocchi, Nicola Cotugno, Paolo Rossi, Caroline Foster, Sara Domínguez-Rodríguez, Alfredo Tagarro, Caitlin Syphurs, Joann Diray-Arce, Benoit Fatou, Al Ozonoff, Ofer Levy, Paolo Palma, Kinga K. Smolen, Carlo Giaquinto, Silvia Faggion, Daniel Gomez Pena, Inger Lindfors Rossi, William James, Alessandra Nardone, Federica D’Ambrosio, Paola Zangari, Carla Paganin, Eleni Nastouli, Moira Spyer, Anne-Genevieve Marcelin, Vincent Calvez, Pablo Rojo, Maria Angeles Munoz, Anita De Rossi, Mark Cotton, Nigel Klein, Deborah Persaud, Rob J. De Boer, Juliane Schroeter, Adriana Ceci, Viviana Giannuzzi, Kathrine Luzuriaga, Louise Kuhn, Andrew Yates, Avy Violari, Kennedy Otwombe, Paula Vaz, Maria Grazia Lain, Elisa López-Varela, Tacilta Nhamposssa, Elisa Lopez, Denise Naniche, Philip Goulder, Mathias Lichterfeld, Holly Peay, Pr Mariam Sylla, Almoustapha Maiga, Thanyawee Puthanakit, Cissy Kityo, and Pediatric Research, 2023
BNT162B2 mRNA COVID-19 Vaccine in Heart and Lung Transplanted Young Adults: Is an Alternative SARS-CoV-2 Immune Response Surveillance Needed? Nicola Cotugno, Chiara Pighi, Elena Morrocchi, Alessandra Ruggiero, Donato Amodio, Chiara Medri, Luna Colagrossi, Cristina Russo, Silvia Di Cesare, Veronica Santilli, Emma Concetta Manno, Paola Zangari, Carmela Giancotta, Stefania Bernardi, Luciana Nicolosi, Marta Ciofi Degli Atti, Massimiliano Raponi, Salvatore Zaffina, Sara Alfieri, Richard Kirk, Carlo Federico Perno, Paolo Rossi, Antonio Amodeo, Paolo Palma Transplantation, 2022
Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology Nicola Cotugno, Alessandra Ruggiero, Giuseppe Rubens Pascucci, Francesco Bonfante, Maria Raffaella Petrara, Chiara Pighi, Loredana Cifaldi, Paola Zangari, Stefania Bernardi, Laura Cursi, Veronica Santilli, Emma Concetta Manno, Donato Amodio, Giulia Linardos, Livia Piccioni, Maria Antonietta Barbieri, Daniela Perrotta, Andrea Campana, Daniele Donà, Carlo Giaquinto, Carlo Concato, Petter Brodin, Paolo Rossi, Anita De Rossi, Paolo Palma, Lorenza Romani, Paola Pansa, Sara Chiurchiu, Andrea Finocchi, Caterina Cancrini, Laura Lancella, Maia De Luca, Renato Cutrera, Alberto Villani, Elena Morrocchi, Sonia Zicari, Lorenza Putignani, Francesca Calò Carducci, Maria A. De Ioris, Patrizia D'Argenio, Marta Ciofi degli Atti, Carmen D'Amore, and Pediatric Allergy and Immunology, 2021
Humoral and Cellular Response Following Vaccination With the BNT162b2 mRNA COVID-19 Vaccine in Patients Affected by Primary Immunodeficiencies Donato Amodio, Alessandra Ruggiero, Mayla Sgrulletti, Chiara Pighi, Nicola Cotugno, Chiara Medri, Elena Morrocchi, Luna Colagrossi, Cristina Russo, Salvatore Zaffina, Gigliola Di Matteo, Cristina Cifaldi, Silvia Di Cesare, Beatrice Rivalta, Lucia Pacillo, Veronica Santilli, Carmela Giancotta, Emma Concetta Manno, Marta Ciofi Degli Atti, Massimiliano Raponi, Paolo Rossi, Andrea Finocchi, Caterina Cancrini, Carlo Federico Perno, Viviana Moschese, Paolo Palma Frontiers in Immunology, 2021
Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies Nicola Cotugno, Alessandra Ruggiero, Francesco Bonfante, Maria Raffaella Petrara, Sonia Zicari, Giuseppe Rubens Pascucci, Paola Zangari, Maria Antonietta De Ioris, Veronica Santilli, E.C. Manno, Donato Amodio, Alessio Bortolami, Matteo Pagliari, Carlo Concato, Giulia Linardos, Andrea Campana, Daniele Donà, Carlo Giaquinto, Petter Brodin, Paolo Rossi, Anita De Rossi, Paolo Palma, Stefania Bernardi, Lorenza Romani, Paola Pansa, Sara Chiurchiú, Andrea Finocchi, Caterina Cancrini, Laura Lancella, Laura Cursi, Maia De Luca, Renato Cutrera, Libera Sessa, Elena Morrocchi, Chiara Medri, Lorenza Putignani, F.I. Calò Carducci, Patrizia D’Argenio, Marta Ciofi degli Atti, Carmen D’Amore, Livia Piccioni, Martina Di Giuseppe, Alessandro Jenkner, Carmela Giancotta, Andrzej Krzysztofiak Cell Reports, 2021
