Long term outcomes of the Indian childhood cancer survivorship (C2S) cohort: a multicentre study (2016–2024) Rachna Seth, Gauri Kapoor, Nirmalya Roy Moulik, Prakruthi Kaushik, Nishant Verma, Amita Mahajan, Priyakumari T, Nita Radhakrishnan, Revathi Raj, Amitabh Singh, Sujata Sharma, Venkatraman Radhakrishnan, Sirishia Rani, Parthasarathi Bhattacharyya, Yamini Krishnan, Piali Mandal, Emine A. Rahiman, Prachi Jain, Debasish Sahoo, Debabrata Mohapatra, Gargi Das, Vineeta Gupta, Gurpreet Singh, Shruti Kakkar, Anuj Singh, Prashant Prabhakar, Arun Kumar AR, Jagdish Prasad Meena, Aditya Kumar Gupta, Payal Malhotra, Chandan Kumar, Siyaram Didel, Shilpa Khanna Arora, Veerendra Patil, Anand Prakash, Purva Kanvinde, Maya Prasad, Jagdish Chandra, Purna Kurkure, Ramandeep Arora Lancet Regional Health Southeast Asia, 2026 Background: Almost 90% of childhood cancers occur in lower income- and middle-income countries (LMICs) like India, leading to a growing population of cancer survivors. However, data on long-term outcomes and late effects are limited. The Indian Childhood Cancer Survivorship (C2S) Study was envisaged to build a nationwide survivor cohort and systematically capture treatment exposures and long-term outcomes. Methods: The C2S study is a prospective multicentric observational cohort initiated in 2016 under the Indian Pediatric Hematology Oncology Group (InPOG-LE-16-01). Children diagnosed with cancer before 18 years of age and in remission post-treatment were enrolled. Demographic, clinical, and treatment exposure data were collected at respective centres and monitored centrally. Follow-up was conducted every three months, assessing survival, relapse, and abandonment rates. Findings: As of December 2024, the study includes data from 20 centres across India with 5419 survivors being enrolled, with survival data available for 5140. Acute leukemia was the most common diagnosis (40.9%). Common therapeutic exposures included chemotherapy (94.7%), surgery (30.3%), and radiotherapy (26.3%). The 5-year overall survival (OS) and event-free survival (EFS) rates for the entire cohort were 94.5% (95% CI: 93.7-95.3)% and 89.9% (95% CI: 88.8-91.0)%, respectively. For the 2266 survivors with ≥2 years post-treatment follow-up, 5 y-OS and EFS were 98.2 (95% CI: 97.5-98.7)% and 95.7 (95% CI: 94.7-96.6)%, respectively. Interpretation: The C2S study represents the first structured attempt to build a nationwide childhood cancer survivors' cohort in India. This cohort will serve as a denominator for future research on late effects, support the development of survivorship guidelines, and inform policy planning in India and comparable LMIC settings. Funding: There was no dedicated funding for this study.
Unusual Presentation of Myeloid Sarcoma as Thigh Mass Sneh Yadav, Shilpa Khanna Arora, Alok Hemal, Sonia Sandip, Geetika Sharma, Prakhya Lalita Jyotsana, Shivkumar M Biradar Journal of Pediatric Health Care, 2025
Acute Pancreatitis as an Initial Manifestation of Pediatric AML: A Case Report with Review of Literature Tanya Singh, Shilpa Khanna Arora, Alok Hemal Indian Journal of Medical and Paediatric Oncology, 2025 Acute myeloid leukemia (AML) accounts for around 15 to 20% of childhood leukemia. Acute leukemia has variable presenting features and extramedullary manifestations typically occur in 10 to 20% of patients with AML, even before bone marrow involvement. Therefore, leukemia may get unnoticed if symptoms from other organs predominate. Acute pancreatitis, as an initial manifestation of acute leukemia, is seen commonly during and after the course of chemotherapy.Here, we report the case of a 16-year-old female patient who presented with pain abdomen, multiple swellings in the neck, axilla, and breast for 2 months and had jaundice at presentation was diagnosed to be having acute pancreatitis with AML. Pancreatitis was resolved after starting cytoreductive chemotherapy. Hence, the causation of pancreatitis in the index case was likely due to pancreatic infiltration by the leukemic cells, unlike the common etiologies such as hypercalcemia and chemotherapy drugs seen in the setting of leukemia.
Unusual case of 'scorbutic proptosis' Shilpa Khanna Arora, Manisha Jana, Rachna Seth BMJ Case Reports, 2024 Proptosis is a frequent presenting symptom/sign of many paediatric malignancies. Acute-onset proptosis is an ophthalmic emergency that can endanger vision if not treated promptly. Appropriate treatment must be instituted only after investigating for the underlying aetiology. Here, we report a developmentally delayed boy in middle childhood who presented with recent onset bilateral proptosis. Clinical examination followed by radiological evaluation suggested scurvy to be the underlying cause and vitamin C supplementation led to prompt reversal of proptosis. The relevant literature has been reviewed and presented here to apprise the paediatric oncologists about this rare but easily treatable cause of proptosis.
Mutation spectrum and enzyme profiling of G6PD deficiency in neonates of north India: a prospective study Upasana Bhattacharyya, Preeti Deswal, Sunil Kumar Polipalli, Diksha Sharma, Manpreet Kaur, Madhulika Kabra, Neerja Gupta, Ramesh Agarwal, A. K. Deorari, V. K. Paul, Shevendru Roy, R. K. Sanjeev, R. S. Tomar, J. S. Bhasin, Amit Tyagi, V. K. Sharma, Anil Gulati, Rajesh Yadav, M. M. A. Faridi, Prerna Batra, Pooja Dewan, Veena Devgan, Alka Mathur, Aseem Bhatnagar, Sunita Bhatia, Ajay Kumar, Sushma Nangia, Arvind Saili, Anju Seth, Deepak Singla, S. K. Arora, S. Mehndiratta, Ashish Jain, Gaurav Pradhan, Sangeeta Gupta, Siddarth Ramji, Mukesh Darshan, S. K. Polipalli, Somesh Kumar, Biju Varughese, Avinash Lomash, Poonam Sidana, Sonia Mitta, Amarjeet Chitkara, Arti Maria, Harish Chellani, K. C. Aggarwa, Shobhna Gupta, Arya Sugandha, Ajay Gambhir, Surinder Bisht, Anand Aggarwal, P. M. Kohli, Indermeet Singh, Seema Kapoor, B. K. Thelma, and Journal of Genetics, 2023
Axillary lymph node in extra-ocular retinoblastoma - Benign or malignant? Shubha Gadde Ravindra, Sambit Sagar, Shilpa Khanna Arora, Rachna Seth, Neiwete Lomi, Rakesh Kumar Indian Journal of Nuclear Medicine, 2023 A 1-year-old male child presented with whitish discoloration of pupil of the left eye and swelling over the left axilla. A contrast-enhanced magnetic resonance imaging of the brain and orbits performed revealed left eye extra-ocular retinoblastoma. 18F-fluorodeoxyglucose positron emission tomography/computed tomography scan was done in this child as a part of baseline staging of retinoblastoma in an ongoing research project. The scan revealed left eye extra-ocular retinoblastoma along with calcified left axillary level I lymph node.
Soluble CD 14–An Emerging Marker in Febrile Neutropenia in Children DN Kharmo, A Hemal, SK Arora Indian Journal of Hematology and Blood Transfusion, 1-5 , 2026 2026
Long term outcomes of the Indian childhood cancer survivorship (C2S) cohort: a multicentre study (2016–2024) R Seth, G Kapoor, NR Moulik, P Kaushik, N Verma, A Mahajan, ... The Lancet Regional Health-Southeast Asia 45 , 2026 2026
Outcomes after Immunosuppressive Therapy for Aplastic Anemia: A Single Centre Experience from Northern India N Kumar, A Hemal, A Sangwan, SK Arora Indian Journal of Hematology and Blood Transfusion 41 (3), 579-584 , 2025 2025
Unusual Presentation of Myeloid Sarcoma as Thigh Mass S Yadav, SK Arora, A Hemal, S Sandip, G Sharma, PL Jyotsana, ... Journal of Pediatric Health Care 39 (4), 668-672 , 2025 2025
Psychiatric Morbidity in Children Undergoing Treatment for Acute Lymphoblastic Leukemia B Kumar, A Hemal, RP Beniwal, SK Arora Indian Journal of Hematology and Blood Transfusion, 1-6 , 2025 2025
Acute Pancreatitis as an Initial Manifestation of Pediatric AML: A Case Report with Review of Literature T Singh, SK Arora, A Hemal Indian Journal of Medical and Paediatric Oncology , 2025 2025
Improving survival in childhood acute lymphoblastic leukemia (ISCALL): An adaptive mixed-method hub-spoke model of implementation of the ICiCLe standard of care across India S Ghosh, S Bakhshi, R Seth, A Trehan, NR Moulik, PS Roy, S Kayal, ... Pediatric Hematology Oncology Journal 10 (4), 100545 , 2025 2025
Evaluation of data quality in childhood cancer survivor cohort: A 10-year review of the InPOG-LE-16-01 study N Patel, S Kumari, R Devgon, C Kumar, D Mohapatra, R Seth, G Kapoor, ... Pediatric Hematology Oncology Journal 10 (4), 100535 , 2025 2025
Oral cryotherapy for prevention of oral mucositis following high dose methotrxate in children with acute lymphoblastic leukemia: A randomised controlled study S Kaul, SK Arora, A Hemal Pediatric Hematology Oncology Journal 10 (4), 100644 , 2025 2025
Knowledge and attitudes to paediatric palliative care among healthcare workers (‘Kappc study’) V Ramesh, K Attri, SK Arora, A Hemal Pediatric Hematology Oncology Journal 10 (4), 100514 , 2025 2025
Hepcidin levels in response to oral iron therapy in children with anemia T Singh, SK Arora, P Goyal, A Hemal Indian pediatrics 61 (9), 823-827 , 2024 2024 Citations: 6
Unusual case of ‘scorbutic proptosis’ SK Arora, M Jana, R Seth BMJ Case Reports CP 17 (1), e253380 , 2024 2024
Vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia D Tanwar, A Hemal, D Sachan, SK Arora Pediatric Hematology Oncology Journal 9 (4), S66 , 2024 2024
Ocular manifestations in children with acute leukemia A Durai, A Hemal, MD Singh, SK Arora Pediatric Hematology Oncology Journal 9 (4), S66 , 2024 2024
Volume 61, January-December, 2024 Y Abdelmeguid, S Abdulrahman, T Abiramalatha, AM Abraham, ... Indian Pediatrics 61 , 2024 2024
Spectrum of psychiatric manifestations in children with acute lymphoblastic leukemia in a tertiary care centre S Arora, B Kumar, A Hemal, RP Beniwal Pediatric Hematology Oncology Journal 9 (4), S36 , 2024 2024
Axillary Lymph Node in Extra-Ocular Retinoblastoma–Benign or Malignant? SG Ravindra, S Sagar, SK Arora, R Seth, N Lomi, R Kumar Indian Journal of Nuclear Medicine 38 (3), 305-306 , 2023 2023
Double trouble: Atypical presentation of myeloid sarcoma as thigh mass complicated by hypercalcemia in a challenging clinical encounter SK Arora, S Yadav, A Hemal, S Sandeep, G Sharma, PL Jyotsana Pediatric Hematology Oncology Journal 8 (4), S86 , 2023 2023
Serum survivin for early detection of retinoblastoma SK Arora, N Lomi, M Jana, L Singh, S Kashyap, S Pathy, RM Pandey, ... Pediatric Hematology Oncology Journal 8 (4), S45 , 2023 2023
Paediatric orbital ultrasound: Tips and tricks A Gupta, SK Arora, R Seth, R Kumar, M Jana Australasian Journal of Ultrasound in Medicine 25 (4), 200-206 , 2022 2022 Citations: 4
MOST CITED SCHOLAR PUBLICATIONS
Defining and measuring vulnerability in young people SK Arora, D Shah, S Chaturvedi, P Gupta Indian Journal of Community Medicine 40 (3), 193-197 , 2015 2015 Citations: 207
Clinicohematological profile and platelet trends in children with dengue during 2010 epidemic in north India H Mittal, MMA Faridi, SK Arora, R Patil The Indian Journal of Pediatrics 79 (4), 467-471 , 2012 2012 Citations: 82
Immune response to second dose of MMR vaccine in Indian children S Gomber, SK Arora, S Das, VG Ramachandran Indian Journal of Medical Research 134 (3), 302-306 , 2011 2011 Citations: 59
Impact of an educational film on parental knowledge of children with cerebral palsy SK Arora, A Aggarwal, H Mittal International journal of pediatrics 2014 (1), 573698 , 2014 2014 Citations: 47
Estimation of gestational age, using neonatal anthropometry: a cross-sectional study in India R Thawani, P Dewan, MMA Faridi, SK Arora, R Kumar Journal of Health, Population, and Nutrition 31 (4), 523 , 2013 2013 Citations: 44
Microbiome: paediatricians’ perspective SK Arora, P Dewan, P Gupta Indian Journal of Medical Research 142 (5), 515-524 , 2015 2015 Citations: 37
Comparison of bone mineral density in thalassemia major patients with healthy controls MC Meena, A Hemal, M Satija, SK Arora, S Bano Advances in hematology 2015 (1), 648349 , 2015 2015 Citations: 37
Predictors of severe dengue amongst children as per the revised WHO classification SK Arora, D Nandan, A Sharma, P Benerjee, DP Singh Journal of Vector Borne Diseases 58 (4), 329-334 , 2021 2021 Citations: 29
Role of organochlorine pesticides in children with idiopathic seizures SK Arora, P Batra, T Sharma, BD Banerjee, S Gupta International Scholarly Research Notices 2013 (1), 849709 , 2013 2013 Citations: 22
Giant primary cerebral hydatid cyst: A rare cause of childhood seizure SK Arora, A Aggarwal, V Datta Journal of Pediatric Neurosciences 9 (1), 73-75 , 2014 2014 Citations: 21
Writing methods: How to write what you did? S Arora, D Shah Indian pediatrics 53 (4) , 2016 2016 Citations: 14
Pediatric HIV disclosure in northern India: evaluation of its prevalence, perceptions amongst caregivers, and its impact on CLHIV R Meena, A Hemal, SK Arora AIDS Research and Treatment 2018 (1), 2840467 , 2018 2018 Citations: 13
Dengue encephalitis in children SK Arora, A Aggarwal, H Mittal Journal of Neurosciences in Rural Practice 3 (2), 228 , 2012 2012 Citations: 13
Giant intramuscular calcifying aponeurotic fibroma of gluteus maximus: case report S Arora, D Sabat, SK Arora, V Kumar, Saran Annals of tropical paediatrics 30 (3), 259-263 , 2010 2010 Citations: 11
Acute lymphoblastic leukemia presenting as nephromegaly in a child: a rare case report SK Arora, S Swarnim, A Hemal, N Bidhuri The Turkish Journal of Pediatrics 61 (1), 97-101 , 2019 2019 Citations: 9
Hepcidin levels in response to oral iron therapy in children with anemia T Singh, SK Arora, P Goyal, A Hemal Indian pediatrics 61 (9), 823-827 , 2024 2024 Citations: 6
Psychiatric problems amongst adolescents living with HIV at a tertiary care centre in India R Pilania, A Hemal, S Agarwal, RP Beniwal, SK Arora Indian Pediatrics 57 (11), 1026-1028 , 2020 2020 Citations: 5
Role of organochlorine pesticides in children with idiopathic seizures. ISRN Pediatr 2013: 849709 SK Arora, P Batra, T Sharma, BD Banerjee, S Gupta 2013 Citations: 5
Teaching with emotional intelligence in higher education S Sharma, S Arora Opinion: International Journal of Management 2 (1), 52-57 , 2012 2012 Citations: 5
Primary aneurysmal bone cyst of the proximal tibia crossing the open physis S Arora, D Sabat, SK Arora, V Kumar, RK Saran Journal of Orthopaedic Science 16 (5), 665-669 , 2011 2011 Citations: 5
