Prakash Saudagar

Scopus Publications

In-vitro biomineralization study of eco-friendly synthesized borosilicate glass with strontium oxide as dopant
Satish Jain, Md Monirujjaman, Locherla Daloji, Raghavendra Gujjala, P. Abdul Azeem, Raj Kumar Samudrala, Prakash Saudagar, Shakuntala Ojha
Ceramics International, 2025
The landscape of intrinsically disordered proteins in Leishmania parasite: Implications for drug discovery
Seshaveena Gollapalli, Banesh Sooram, Hitesh Sugandh, Prakash Saudagar
International Journal of Biological Macromolecules, 2024
A comprehensive study on bioactivity, mechanical and tribological behavior of copper-doped borosilicate glass derived from natural waste for dental applications
Satish Jain, Raghavendra Gujjala, Hemanth Boyina, P. Abdul Azeem, Raj Kumar Samudrala, Prakash Saudagar, Sooram Banesh
Ceramics International, 2024
A novel approach to design chimeric multi epitope vaccine against Leishmania exploiting infected host cell proteome
Sooram Banesh, Neharika Gupta, Chethireddy Vihadhar Reddy, Uppuladinne Mallikarjunachari, Nupoor Patil, Sonavane Uddhavesh, Prakash Saudagar
Heliyon, 2024
Leishmaniasis is a major infectious disease having high mortality which could be attributed to lack of a suitable vaccine candidate. We propose a novel approach to design multiepitope vaccine to leishmaniasis exploiting specific membrane proteome from infected macrophage from host. The MHC-I, MHC-II and BC epitopes predicted for unique proteins from the infected macrophages and Leishmania and a MEV designed in various combinations (1a-1m). The epitope arrangements 1a, 1k, 1l, and 1m showed a strong antigenicity profile and immune response. The molecular dynamics simulation indicate the 1k, 1l, and 1m constructs have strong affinity toward TLR-2, TLR-3, and TLR-4. Overall the structural and immunogenicity profile suggests 1k is top candidate. Further, a computational model system with TLR-2, TLR-3, TLR-4, BCR, MHC-I and MHC-II was generated for 1k construct to understand the MEV interactions with immune components. Dihedral distribution and distance was enumerated to understand the movement of immune components towards 1k. The results indicate 1k has strong affinity for the immune response molecules especially TLR-3, BCR and MHC-II are coming in close contact with the MEV through the simulation. The study suggests that designed multi-epitope vaccine 1k has potential to induce proper immune response but warrants further studies. Leishmaniasis is a major infectious disease having high mortality which could be attributed to lack of a suitable vaccine candidate. We propose a novel approach to design multiepitope vaccine to leishmaniasis exploiting specific membrane proteome from infected macrophage from host. The MHC-I, MHC-II and BC epitopes predicted for unique proteins from the infected macrophages and Leishmania and a MEV designed in various combinations (1a-1m). The epitope arrangements 1a, 1k, 1l, and 1m showed a strong antigenicity profile and immune response. The molecular dynamics simulation indicate the 1k, 1l, and 1m constructs have strong affinity toward TLR-2, TLR-3, and TLR-4. Overall the structural and immunogenicity profile suggests 1k is top candidate. Further, a computational model system with TLR-2, TLR-3, TLR-4, BCR, MHC-I and MHC-II was generated for 1k construct to understand the MEV interactions with immune components. Dihedral distribution and distance was enumerated to understand the movement of immune components towards 1k. The results indicate 1k has strong affinity for the immune response molecules especially TLR-3, BCR and MHC-II are coming in close contact with the MEV through the simulation. The study suggests that designed multi-epitope vaccine 1k has potential to induce proper immune response but warrants further studies.
Design and evaluation of a multiepitope vaccine for pancreatic cancer using immune-dominant epitopes derived from the signature proteome in expression datasets
Sooram Banesh, Nupoor Patil, Vihadhar Reddy Chethireddy, Arnav Bhukmaria, Prakash Saudagar
Medical Oncology, 2024
Corrigendum to “Biofunctionalized chrysin-conjugated gold nanoparticles neutralize Leishmania parasites with high efficacy” [Int. J. Biol. Macromol. Volume 205, 30 April 2022, Pages 211–219] (International Journal of Biological Macromolecules (2022) 205 (211–219), (S0141813022002835), (10.1016/j.ijbiomac.2022.02.047))
Shweta Raj, Santanu Sasidharan, Timir Tripathi, Prakash Saudagar
International Journal of Biological Macromolecules, 2024
Pharmacophore-guided drug design using LdNMT as a model drug target for leishmaniasis
Banesh Sooram, Uppuladinne Mallikarjunachari, Sonavane Uddavesh, Prakash Saudagar
Journal of Biomolecular Structure and Dynamics, 2024
Leishmaniasis is caused by Leishmania genus parasites and has a high mortality rate. The available drugs to treat leishmaniasis fail due to acquired resistance in parasites. Several enzymes of the Leishmania parasite have been used to design new therapeutic molecules against leishmaniasis. This study uses a pharmacophore-guided approach to design the drug candidate by targeting Leishmania N-Myristoyl transferase (LdNMT). From the initial sequence analysis of LdNMT, we have identified a unique 20 amino acid stretch exploited for screening and designing the small molecules. The pharmacophore for the myristate binding site on LdNMT was elucidated, and a heatmap was constructed. The leishmanial NMT pharmacophore has similarities with other pathogenic microorganisms. Moreover, substituting alanine in pharmacophoric residues elevates the affinity of myristate with NMT. Furthermore, a molecular dynamics (MD) simulation study was conducted to ascertain the stability of the mutants and or wild type. The wild-type NMT has a comparatively low affinity to myristate compared to alanine mutants, indicating that hydrophobic residues favor the myristate binding. The molecules were initially designed by using pharmacophore as a sieving mechanism. In subsequent steps, the selected molecules screened against leishmanial unique amino acid stretch and subsequently with human, leishmanial full-size NMTs. The compounds BP5, TYI, DMU, 3PE and 4UL were the top hits and chemical features similar to the myristate. The molecule 4UL was found to be highly specific towards leishmanial NMT over human NMT, suggesting the molecule is a strong leishmanial NMT inhibitor. The molecule can be taken further to assess it in in-vitro conditions.
4′,7-dihydroxyflavone conjugated carbon nanotube formulation demonstrates improved efficacy against Leishmania parasite
Santanu Sasidharan, Prakash Saudagar
Biochimica Et Biophysica Acta General Subjects, 2023
An anti-leishmanial compound 4′,7-dihydroxyflavone elicits ROS-mediated apoptosis-like death in Leishmania parasite
Santanu Sasidharan, Prakash Saudagar
FEBS Journal, 2023
The treatment for leishmaniasis is currently plagued by side effects such as toxicity, and the emergence of drug resistance to the available repertoire of drugs, as well as the expense of these drugs. Considering the rising concerns, we report here , the anti-leishmanial activity and mechanism of a flavone compound 4',7-dihydroxyflavone (TI 4). Four flavanoids were initially screened for anti-leishmanial activity and cytotoxicity. The results showed that the compound TI 4 exhibited higher activity and selectivity index while maintaining low cytotoxicity. Preliminary microscopic studies and FACS analysis reported that the parasite underwent apoptosis on TI 4 treatment. Further in-depth studies revealed high ROS production and thiol levels in the parasites suggesting ROS mediated apoptosis in the parasites upon TI 4 treatment. Other apoptotic indicators like intracellular Ca2+ and mitochondrial membrane potential also indicated the onset of apoptosis in the treated parasites. The mRNA expression levels signified that the redox metabolism genes were upregulated by 2-fold along with the apoptotic genes. In summary, the use of TI 4 on Leishmania parasites induces ROS-mediated apoptosis, therefore the compound has immense potential to be an anti-leishmanial drug. However, in vivo studies would be required to ascertain its safety and efficacy before we can exploit the compound against the growing leishmaniasis crisis.
Deciphering the intrinsic dynamics of unphosphorylated IRAK4 kinase bound to type I and type II inhibitors
Vijayakumar Gosu, Santanu Sasidharan, Prakash Saudagar, Kamalakannan Radhakrishnan, Hak-Kyo Lee, Donghyun Shin
Computers in Biology and Medicine, 2023
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a vital protein involved in Toll-like and interleukin-1 receptor signal transduction. Several studies have reported regarding the crystal structure, dynamic properties, and interactions with inhibitors of the phosphorylated form of IRAK4. However, no dynamic properties of inhibitor-bound unphosphorylated IRAK4 have been previously studied. Herein, we report the intrinsic dynamics of unphosphorylated IRAK4 (uIRAK4) bound to type I and type II inhibitors. The corresponding apo and inhibitor-bound forms of uIRAK4 were subjected to three independent simulations of 500 ns (total 1.5 μs) each, and their trajectories were analyzed. The results indicated that all three systems were relatively stable, except for the type II inhibitor-bound form of uIRAK4, which exhibited less compact folding and higher solvent surface area. The intra-hydrogen bonds corroborated the structural deformation of the type-II inhibitor-bound complex, which could be attributed to the long molecular structure of the type-II inhibitor. Moreover, the type II inhibitor bound to uIRAK4 showed higher binding free energy with uIRAK4 than the type I inhibitor. The free energy landscape analysis showed a reorientation of Phe330 side chain from the DFG motif at different metastable states for all the systems. The intra-residual distance between residues Lys213, Glu233, Tyr262, and Phe330 suggests a functional interplay when the inhibitors are bound to uIRAK4, thereby hinting at their crucial role in the inhibition mechanism. Ultimately, the intrinsic dynamics study observed between type I/II inhibitor-bound forms of uIRAK4 may assist in better understanding the enzyme and designing therapeutic compounds.
Molecular dynamics of the ERRγ ligandbinding domain bound with agonist and inverse agonist
Santanu Sasidharan, Kamalakannan Radhakrishnan, Jun-Yeong Lee, Prakash Saudagar, Vijayakumar Gosu, Donghyun Shin
Plos One, 2023
meso-Carbazole decorated BODIPYs - an electron donor-acceptor system with excellent fluorosolvato/vapochromic behavior, aggregation-induced emission, and antileishmanial activity
Diana Mathew, Santanu Sasidharan, Prakash Saudagar, Subramaniam Sujatha, Pattiyil Parameswaran
New Journal of Chemistry, 2023
Protein Folding Dynamics and Stability: Experimental and Computational Methods
Prakash Saudagar, Timir Tripathi
Protein Folding Dynamics and Stability Experimental and Computational Methods, 2023
Preface
Protein Folding Dynamics and Stability Experimental and Computational Methods, 2023
Fluorescence Spectroscopy-Based Methods to Study Protein Folding Dynamics
Ritesh Kumar, Timir Tripathi, Prakash Saudagar
Protein Folding Dynamics and Stability Experimental and Computational Methods, 2023
Discovery of compounds inhibiting SARS-COV-2 multi-targets
Santanu Sasidharan, Neellohit Sarkar, Prakash Saudagar
Journal of Biomolecular Structure and Dynamics, 2023
Simplified CRISPR-Mediated DNA Editing in Multicellular Eukaryotes
Ritesh Kumar, Kartikeya Tiwari, Prakash Saudagar
Methods in Molecular Biology, 2023
Design of SaCas9-HF for In Vivo Gene Therapy
Kartikeya Tiwari, Ritesh Kumar, Prakash Saudagar
Methods in Molecular Biology, 2023
pH-Based Molecular Dynamics Simulation for Analysing Protein Structure and Folding
Santanu Sasidharan, Rohit Shukla, Timir Tripathi, Prakash Saudagar
Protein Folding Dynamics and Stability Experimental and Computational Methods, 2023
Gene Alterations Induced by Glutamine (Q) Encoding CAG Repeats Associated with Neurodegeneration
Gundappa Saha, Sukanya Ghosh, Vikash Kumar Dubey, Prakash Saudagar
Methods in Molecular Biology, 2023
Molecular Dynamics Simulation to Study Protein Conformation and Ligand Interaction
Santanu Sasidharan, Vijayakumar Gosu, Timir Tripathi, Prakash Saudagar
Protein Folding Dynamics and Stability Experimental and Computational Methods, 2023
In Vitro Assay for the Assessment of Oxygen Depletion Triggers in Human Cell Lines, Associated with Improving Responses to Cancer Therapy
Kartikeya Tiwari, Ritesh Kumar, Gundappa Saha, Prakash Saudagar
Methods in Molecular Biology, 2023
Applications of Differential Scanning Calorimetry in Studying Folding and Stability of Proteins
Banesh Sooram, Neharika Gupta, Vihadhar Reddy Chethireddy, Timir Tripathi, Prakash Saudagar
Protein Folding Dynamics and Stability Experimental and Computational Methods, 2023
Knockout of Tyrosine Aminotransferase Gene by Homologous Recombination Arrests Growth and Disrupts Redox Homeostasis in Leishmania Parasite
Santanu Sasidharan, Prakash Saudagar
Parasitology Research, 2022
Novel ultrasonic atomization approach for sunflower oil in water emulsion
S. B. Potdar, P. Saudagar, I. Potoroko, S. H. Sonawane
Aip Conference Proceedings, 2022
ANN-based modelling of peppermint flavour encapsulation process with ultrasound approach
Shital B. Potdar, Bharat A. Bhanvase, Prakash Saudagar, Irina Potoroko, Shirish H. Sonawane
Canadian Journal of Chemical Engineering, 2022
Gold and silver nanoparticles functionalized with 4’,7-dihydroxyflavone exhibit activity against Leishmania donovani
S. Sasidharan, Prakash Saudagar
Acta Tropica, 2022
Photodynamic evaluation of triazine appended porphyrins as anti-leishmanial and anti-tumor agents
Monisha Manathanath, Santanu Sasidharan, Prakash Saudagar, Unnikrishnan Gopalakrishna Panicker, Subramaniam Sujatha
Polyhedron, 2022
Biofunctionalized Chrysin-conjugated gold nanoparticles neutralize Leishmania parasites with high efficacy
Shweta Raj, Santanu Sasidharan, Timir Tripathi, Prakash Saudagar
International Journal of Biological Macromolecules, 2022
Phase separation of FG-nucleoporins in nuclear pore complexes
Niharika Nag, Santanu Sasidharan, Vladimir N. Uversky, Prakash Saudagar, Timir Tripathi
Biochimica Et Biophysica Acta Molecular Cell Research, 2022
Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition
Sushma Subedi, Santanu Sasidharan, Niharika Nag, Prakash Saudagar, Timir Tripathi
Molecules, 2022
Influence of SeO2 on in vitro bioactivity and antibacterial activity of CaF2–CaO–B2O3–P2O5–SrO glass system
B. Madhavi, A. Siva Sesha Reddy, P. Syam Prasad, Prakash Saudagar, P. Venkateswara Rao, V. Ravi Kumar, N. Veeraiah
Materials Chemistry and Physics, 2022
Preface
Prakash Saudagar, Timir Tripathi
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics, 2022
Prediction, validation, and analysis of protein structures: A beginner’s guide
Santanu Sasidharan, Prakash Saudagar
Advances in Protein Molecular and Structural Biology Methods, 2022
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics, 2022
Experimental methods to study the thermodynamics of protein-protein interactions
Santanu Sasidharan, Niharika Nag, Timir Tripathi, Prakash Saudagar
Advances in Protein Molecular and Structural Biology Methods, 2022
Fundamentals of spectroscopy for biomolecular structure and dynamics
Niharika Nag, Santanu Sasidharan, Prakash Saudagar, Timir Tripathi
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics, 2022
Interactions and interplay of MLOs with classical membrane-bound organelles
Santanu Sasidharan, Niharika Nag, Timir Tripathi, Prakash Saudagar
Droplets of Life Membrane Less Organelles Biomolecular Condensates and Biological Liquid Liquid Phase Separation, 2022
Integration of spectroscopic and computational data to analyze protein structure, function, folding, and dynamics
Kavya Prince, Santanu Sasidharan, Niharika Nag, Timir Tripathi, Prakash Saudagar
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics, 2022
Applications of infrared spectroscopy to study proteins
Riya Sahu, Banesh Sooram, Santanu Sasidharan, Niharika Nag, Timir Tripathi, Prakash Saudagar
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics, 2022
Critical Insight into Plausible Acquired Tocopherol Pathway in Neglected Human Trypanosomatids
Santanu Sasidharan, Timir Tripathi, Prakash Saudagar
ACS Omega, 2021
Interface-based design of the favipiravir-binding site in SARS-CoV-2 RNA-dependent RNA polymerase reveals mutations conferring resistance to chain termination
Aditya K. Padhi, Jagneshwar Dandapat, Prakash Saudagar, Vladimir N. Uversky, Timir Tripathi
FEBS Letters, 2021
Computational insights into the structural dynamics of mda5 variants associated with aicardi–goutières syndrome and singleton–merten syndrome
Vijayakumar Gosu, Santanu Sasidharan, Prakash Saudagar, Hak-Kyo Lee, Donghyun Shin
Biomolecules, 2021
Therapeutic p28 peptide targets essential H1N1 influenza virus proteins: insights from docking and molecular dynamics simulations
Santanu Sasidharan, Vijayakumar Gosu, Donghyun Shin, Subhradip Nath, Timir Tripathi, Prakash Saudagar
Molecular Diversity, 2021
Leishmaniasis: where are we and where are we heading?
Santanu Sasidharan, Prakash Saudagar
Parasitology Research, 2021
High-throughput rational design of the remdesivir binding site in the RdRp of SARS-CoV-2: implications for potential resistance
Aditya K. Padhi, Rohit Shukla, Prakash Saudagar, Timir Tripathi
Iscience, 2021
Synthesis, TDDFT Calculations and Biological Evaluation of Dicationic Porphyrins as Groove Binders and Antimicrobial Agents
Diana Mathew, Jagadeesan Ramesh, Santanu Sasidharan, Kannan Subburaj, Prakash Saudagar, Pattiyil Parameswaran, Subramaniam Sujatha
Chemistryselect, 2021
Bacterial protein azurin and derived peptides as potential anti-SARS-CoV-2 agents: insights from molecular docking and molecular dynamics simulations
Santanu Sasidharan, Chandrabose Selvaraj, Sanjeev Kumar Singh, Vikash Kumar Dubey, Sachin Kumar, Arsenio M. Fialho, Prakash Saudagar
Journal of Biomolecular Structure and Dynamics, 2021
Culture-Independent Omics-Techniques for Microbiome-Based Molecular Therapeutics Against Infectious Diseases
Santanu Sasidharan, K. Divakar, Prakash Saudagar
Metagenomic Systems Biology Integrative Analysis of the Microbiome, 2020
Mapping N- and C-terminals of Leishmania donovani tyrosine aminotransferase by gene truncation strategy: a functional study using in vitro and in silico approaches
Santanu Sasidharan, Prakash Saudagar
Scientific Reports, 2020
Flavones reversibly inhibit Leishmania donovani tyrosine aminotransferase by binding to the catalytic pocket: An integrated in silico-in vitro approach
Santanu Sasidharan, Prakash Saudagar
International Journal of Biological Macromolecules, 2020
Exploring the Zika Genome to Design a Potential Multiepitope Vaccine Using an Immunoinformatics Approach
Ayushi Mittal, Santanu Sasidharan, Shweta Raj, S. N. Balaji, Prakash Saudagar
International Journal of Peptide Research and Therapeutics, 2020
Computational design of a potential multi-epitope subunit vaccine using immunoinformatics to fight Ebola virus
Ajinkya Kadam, Santanu Sasidharan, Prakash Saudagar
Infection Genetics and Evolution, 2020
An overview of biochemically characterized drug targets in metabolic pathways of Leishmania parasite
Shweta Raj, Santanu Sasidharan, S. N. Balaji, Prakash Saudagar
Parasitology Research, 2020
Concerted motion of structure and active site charge is required for tyrosine aminotransferase activity in Leishmania parasite
Santanu Sasidharan, Prakash Saudagar
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2020
Utilising capsid proteins of poliovirus to design a multi-epitope based subunit vaccine by immunoinformatics approach
Nitin Bohra, Santanu Sasidharan, Shweta Raj, S. N. Balaji, Prakash Saudagar
Molecular Simulation, 2020
Encapsulation and delivery of antiparasitic drugs: a review
Santanu Sasidharan, Prakash Saudagar
Encapsulation of Active Molecules and their Delivery System, 2020
Virus-like particles: nano-carriers in targeted therapeutics
Gundappa Saha, Prakash Saudagar, Vikash Kumar Dubey
Encapsulation of Active Molecules and their Delivery System, 2020
Role of phenols and polyphenols in plant defense response to biotic and abiotic stresses
Palistha Tuladhar, Santanu Sasidharan, Prakash Saudagar
Biocontrol Agents and Secondary Metabolites Applications and Immunization for Plant Growth and Protection, 2020
Green-synthesized feso4 nanoparticles exhibit antibacterial and cytotoxic activity by dna degradation
B. Bharath, Santanu Sasidharan, Sai K. Bhamidipati, Prakash Saudagar
Current Pharmaceutical Biotechnology, 2020
Biochemical characterization and chemical validation of Leishmania MAP Kinase-3 as a potential drug target
Shweta Raj, Gundappa Saha, Santanu Sasidharan, Vikash Kumar Dubey, Prakash Saudagar
Scientific Reports, 2019
Biochemical and structural characterization of tyrosine aminotransferase suggests broad substrate specificity and a two-state folding mechanism in Leishmania donovani
Santanu Sasidharan, Prakash Saudagar
FEBS Open Bio, 2019
Plant metabolites as new leads to drug discovery
Santanu Sasidharan, Prakash Saudagar
Natural Bio Active Compounds Chemistry Pharmacology and Health Care Practices, 2019
Identification of lead molecules against potential drug target protein MAPK4 from L. Donovani: An in-silico approach using docking, molecular dynamics and binding free energy calculation
Shweta Raj, Santanu Sasidharan, Vikash Kumar Dubey, Prakash Saudagar
Plos One, 2019
An overview of protein/metabolite based advances in monitoring tools and biosensors: Benefits and application in environmental toxicology
Santanu Sasidharan, Prakash Saudagar
Tools Techniques and Protocols for Monitoring Environmental Contaminants, 2019
Plant cell culture as alternatives to produce secondary metabolites
Shweta Raj, Prakash Saudagar
Natural Bio Active Compounds Volume 3 Biotechnology Bioengineering and Molecular Approaches, 2019
Nanomaterial synthesis: Chemical and biological route and applications
Santanu Sasidharan, Shweta Raj, Shirish Sonawane, Shriram Sonawane, Dipak Pinjari, A.B. Pandit, Prakash Saudagar
Nanomaterials Synthesis Design Fabrication and Applications, 2019
Episomal expression of human glutathione reductase (HuGR) in Leishmania sheds light on evolutionary pressure for unique redox metabolism pathway: Impaired stress tolerance ability of Leishmania donovani
Jay Prakash, Sunita Yadav, Gundappa Saha, Adarsh Kumar Chiranjivi, Suresh Kumar, Santanu Sasidharan, Prakash Saudagar, Vikash Kumar Dubey
International Journal of Biological Macromolecules, 2019
Novel Schiff base metal complexes: synthesis, characterization, DNA binding, DNA cleavage and molecular docking studies
Mayuri Bheemarasetti, Kavitha Palakuri, Shweta Raj, Prakash Saudagar, Durgaiah Gandamalla, Narsimha Reddy Yellu, Laxma Reddy Kotha
Journal of the Iranian Chemical Society, 2018
Carbon nanotube based betulin formulation shows better efficacy against Leishmania parasite
Prakash Saudagar, Vikash Kumar Dubey
Parasitology International, 2014
Discovery of novel anti-leishmanial agents targeting LdLip3 lipase
Saravanan Parameswaran, Prakash Saudagar, Vikash Kumar Dubey, Sanjukta Patra
Journal of Molecular Graphics and Modelling, 2014
Molecular mechanisms of in vitro betulin-induced apoptosis of Leishmania donovani
Prakash Saudagar, Vikash Kumar Dubey
American Journal of Tropical Medicine and Hygiene, 2014
In vivo assessment of antileishmanial property of 4-(4,4,8-trimethyl-7-oxo- 3-oxabicyclo[3.3.1]non-2-yl)-benzoic acid methyl ester, an oxabicyclo[ 3.3.1]nonanones
Prakash Saudagar, Shyam Mudavath, Pipas Saha, Anil Saikia, Shyam Sundar, Vikash Dubey
Letters in Drug Design and Discovery, 2014
Miltefosine-unresponsive Leishmania donovani has a greater ability than miltefosine-responsive L. donovani to resist reactive oxygen species
Mousumi Das, Prakash Saudagar, Shyam Sundar, Vikash K. Dubey
FEBS Journal, 2013
Evaluation of a diospyrin derivative as antileishmanial agent and potential modulator of ornithine decarboxylase of Leishmania donovani
Sudipta Hazra, Subhalakshmi Ghosh, Madhushree Das Sarma, Smriti Sharma, Mousumi Das, Prakash Saudagar, Vijay Kumar Prajapati, Vikash Kumar Dubey, Shyam Sundar, Banasri Hazra
Experimental Parasitology, 2013
Molecular mechanism underlying antileishmanial effect of oxabicyclo[3.3.1]nonanones: Inhibition of key redox enzymes of the pathogen
Prakash Saudagar, Pipas Saha, Anil K. Saikia, Vikash Kumar Dubey
European Journal of Pharmaceutics and Biopharmaceutics, 2013
Nanobiosciences: A contemporary approach in antiparasitic drugs
Molecular and Cellular Pharmacology, 2012
Epitopic analysis of potential vaccine candidate in Leishmania infantum for development of human vaccine
Abhinav Grover, Sushil Kumar Shakyawar, Prakash Saudagar, Vikash Kumar Dubey, Durai Sundar
Letters in Drug Design and Discovery, 2012
Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani
Prakash Saudagar, Vikash Kumar Dubey
Biological Chemistry, 2011
Screening natural products database for identification of potential antileishmanial chemotherapeutic agents
Santhosh K. Venkatesan, Prakash Saudagar, Anil K. Shukla, Vikash Kumar Dubey
Interdisciplinary Sciences Computational Life Sciences, 2011

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