AMITESH AGGARWAL

@ucms.ac.in

Director Professor & Unit Head, Department of Medicine
University College of Medical Sciences & GTB Hospital, Delhi

AMITESH AGGARWAL


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https://researchid.co/dramitesh

RESEARCH, TEACHING, or OTHER INTERESTS

Health Professions, General Medicine, Internal Medicine
59

Scopus Publications

Scopus Publications

  • Thiamine supplementation in the management of diabetic ketoacidosis: An open-label, randomized controlled trial
    Alisha Khan, Shiva Narang, Amitesh Aggarwal, Nishant Raizada
    Endocrine and Metabolic Science, 2026
    Background Diabetic ketoacidosis (DKA) is an acute complication of diabetes mellitus with significant mortality. Emerging evidence suggests a potential role for thiamine, as an adjuvant therapy in DKA management. This study explored the effect of thiamine supplementation on the resolution of DKA. Methods An open-label, randomized controlled trial was conducted at a tertiary care facility. Sixty adult DKA patients were randomized into two groups, using online randomization generator. Thirty patients (intervention group) received thiamine supplementation with standard DKA therapy, and thirty patients (active control group) received only standard DKA therapy. Baseline investigations were performed and statistical analyses were conducted to compare time to resolution of ketoacidosis, morbidity, mortality, and adverse events between the two groups. Results The study showed no significant difference between the demographic, clinical and laboratory parameters within the two groups. In the intervention vs the active control group, time to resolution of DKA (9.6 vs. 9.9 h, p = 0.342), duration of hospital stays (4.2 vs. 3.7 days, p = 0.157), and complications (20 % vs. 10 %, p = 0.472) showed no significant statistical differences. Infections (41.7 %) and non-compliance (38.3 %) were leading causes for precipitation of DKA. No adverse events were observed. Conclusion There was no statistically significant difference between the two study groups. Given the safety profile, easy availability and cost effectiveness of thiamine, further research is warranted in larger cohorts to validate the potential therapeutic role of thiamine as adjuvant in DKA management.
  • Abnormalities of Endocrine Function Tests in COVID‑19‑Recovered Individuals
    Phibakordor L. Nonglait, Srivenkata Madhu, Nishant Raizada, Amitesh Aggarwal, Rafat Ahmed, Mohammad Aslam
    Indian Journal of Endocrinology and Metabolism, 2025
    Introduction: Impact of COVID-19 on endocrine system due to the widespread distribution of Angiotensin Converting Enzyme-2 (ACE2) receptors in different endocrine organs of the body has been shown in several studies. However, most of these studies were in the setting of acute COVID-19. The present study was planned to comprehensively evaluate endocrine abnormalities in COVID-19-recovered individuals. Methods: Eighty-three COVID-19-recovered individuals were recruited 8-20 weeks following the recovery. They were further stratified according to disease severity as defined by the Indian Council of Medical Research (ICMR). After recording their demographic and clinical details, an evaluation of inflammatory markers and different hypothalamic-pituitary axes involving thyroid, adrenal, gonadal and prolactin axes was carried out in them. Those who were on treatment for a previous endocrine disorder were not included in the study. Results: Eighty-three patients [33 (39.7%): mild and 50 (60.3%): moderate to severe COVID-19] were recruited after a period of 14.7 ± 3.4 weeks after recovery. Forty-four patients (53%) had some form of endocrine dysfunction. Central pituitary axis dysfunction was observed in 28 patients (33.7%), of which alterations in prolactin (20.4%) were the most common. Thyroid function abnormalities were noted in 25 (30.1%) patients, while gonadal dysfunction was detected in 14% of males and 6% of reproductive-aged females, respectively. Conclusion: Endocrine function test abnormalities were seen in a significant proportion of individuals even after a mean period of more than 3 months post-recovery from COVID-19. These have implications for the long-term endocrine and metabolic health of COVID-19-recovered individuals, besides alerting physicians to interpret endocrine function tests with caution after recovery from acute COVID-19 illness.
  • Position statement on hypertension by Indian Society of Hypertension, 2023
    Anuj Maheshwari, Rajeev Gupta, Narsingh Verma, S. N. Narasingan, Ram B. Singh, Banshi Saboo, C. H. Vasanth Kumar, Arvind Gupta, Manoj K. Srivastava, Amit Gupta, Saurabh Srivastava, Amitesh Aggarwal, Ajoy Tewari, Sajid Ansari, Bijay Patni, Dinesh Agarwal, G. B. Sattur, Lily Rodrigues, K. K. Pareek, Murar Yeolekar, Samar Banerjee, L. Sreenivasamurthy, M. K. Das, Shashank Joshi, Shailendra Vajpeyee, V. V. Muthusamy, A. Muruganathan
    Journal of Human Hypertension, 2024
  • Impact of BCG Vaccination on Morbidity and Mortality among Adult Patients with Tuberculous Meningitis: A Prospective Cohort Analysis
    Journal Indian Academy of Clinical Medicine, 2024
  • Nail fold capillaroscopy in leprosy: Unveiling the microvascular changes
    Bharti Aggarwal, Vijay Gandhi, Archana Singal, Amitesh Aggarwal, Sushobhan Saha
    Microvascular Research, 2024
  • May Measurement Month 2021: an analysis of blood pressure screening campaign results from India
    Anuj Maheshwari, Narsingh Verma, Jalees Fatima, Ajoy Tewari, Jothydev Kesavdev, Preeti Singh Dhoat, Amrit Kaur, Amit Gupta, Saurabh Srivastava, Abhinav Verma, Shivangi Maheshwari, Sajid Ansari, Amitesh Aggarwal, Abhishek Srivastava, Vanshika Arora, Thomas Beaney, Jonathan Clarke, Neil R Poulter
    European Heart Journal Supplement, 2024
    Raised blood pressure (BP) is the leading preventable risk factor for cardiovascular diseases that makes a major impact on early mortality and morbidity. Recognizing hypertension in the community, educating people about routine BP monitoring, and improving medication compliance are all important steps in detecting, controlling, and managing hypertension. During the course of 5 months, members of the Indian Society of Hypertension organized unique medical indoor and outdoor camps at 100 screening locations around India for the May Measurement Month (MMM) 2021 study. At every location, BP was measured three times, and a questionnaire was completed. Participants known to have hypertension before the study whether taking or not taking treatment were not included (not a normal pre-requisite for exclusion in MMM). The analysis included 15 045 participants in total. After calculating the average of the second and third BP measurements, 16.4% of participants were found to have hypertension based on ≥140/90 mmHg thresholds (2461 out of 15 045). 14.0% of females and 16.4% of males had hypertension. 16.4% of participants had undiagnosed hypertension and were not receiving treatment. The MMM screening campaign has the potential for identifying large numbers of people with undiagnosed hypertension and raising awareness of the importance of raised BP among the general public, medical professionals, policymakers, the government, and the media. Future BP screening campaigns should be larger in scope and involve follow-ups with past participants.
  • Long-Term Persistence of COVID-Induced Hyperglycemia: A Cohort Study
    Vrinda Goel, Alpana Raizada, Amitesh Aggarwal, SV Madhu, Rajarshi Kar, Ananya Agrawal, Vikash Mahla, Ashish Goel
    American Journal of Tropical Medicine and Hygiene, 2024
    Although the short-term mortality of patients with COVID-19 infection and hyperglycemia has been well documented, there is little available data regarding longer-term prognosis. The presence of diabetes has not only influenced disease severity but has also impacted its transmission dynamics. In this study, we followed a historical cohort of patients without previous history of diabetes who presented with moderate to severe COVID-19 and were found to have hyperglycemia (random blood glucose > 140 mg/dL) at the time of admission. We evaluated the need for antidiabetic therapy in these patients at the end of 6 months and the risk factors associated with persistent hyperglycemia determined by monthly values of self-monitored blood glucose. Of the seventy participants who were followed telephonically, 54 (77%) continued to receive antidiabetic therapy or have persistent hyperglycemia (> 140 mg/dL) at the end of 6 months. Persistent hyperglycemia at the end of follow-up, was found to be associated with a higher blood glucose at presentation.
  • Health Decline in Older Adults
    Journal of the Indian Medical Association, 2023
  • The increasing presence of the internet in the lives of patients and doctors: threat or opportunity?
    FNU Anamika, Ashish Goel, Amitesh Aggarwal, Ramansh Bandhu Gupta
    Indian Journal of Medical Ethics, 2023
    The conventional sharing of information and education between doctor and patient is no longer what it used to be prior to Dr. Google’s entry into the mix with voluminous data, not only transforming but often threatening the patient-doctor relationship. While patients no longer seek basic information from their physicians since they’ve already consulted Dr. Google, the wise physician accepts that patients are now more aware, more involved in their own care, and more empowered with information. The good old doctor who knew everything is now more a myth that exists largely in folklore. While doctors may be well versed in a variety of fields, they have often narrowed down their areas of specialisation, while they continue to apply what they learn from their daily encounters with patients, establishing a stronger relationship over time. The challenge arises when a patient, having consulted Dr. Google, starts to question their doctor with the little knowledge gained from the internet. Biased opinions based on prior knowledge, have lately placed the doctor-patient relationship in jeopardy.
  • High level of psychological stress in COVID-19 recovered individuals: role of copeptin as a potential biomarker
    Phibakordor Lyngdoh Nonglait, Sri Venkata Madhu, Nishant Raizada, Amitesh Aggarwal, Rafat Ahmed, Mohammad Aslam
    Frontiers in Psychology, 2023
    BackgroundStudy aimed to assess stress in COVID-19 recovered individuals using a validated questionnaire PSS-10 score and stress biomarkers – salivary cortisol and serum copeptin.MethodsA total of 83 subjects of which 54 subjects (66.3%) who were hospitalized were recruited 8–20 weeks following recovery from COVID-19. Stress was assessed by PSS-10 stress-scale after a mean duration of 14.5 weeks after recovery. Sixty-eight subjects (81.9%) had new or persistent symptoms after recovery. Subjects were divided into two groups on the basis of PSS score; mild stress (PSS:0–13) and moderate to severe stress (PSS:>14) and levels of biomarkers (serum copeptin, DHEAS and salivary cortisol) were compared in the two groups.ResultsForty-four subjects (53%) had moderate to severe stress and 39 subjects (47%) had mild stress. Subjects with post COVID symptoms had significantly higher stress levels as compared to subjects who were asymptomatic [15 vs. 9; p = 0.003]. Serum copeptin levels were significantly higher among subjects with moderate to severe stress as compared to those with mild stress [0.41 vs. 0.67 ng/mL; p = 0.031]. Subjects with moderate to severe stress had higher median salivary cortisol compared to subjects with mild stress [1.03 vs. 1.44 nmol/L; p = 0.448].ConclusionOur study demonstrated moderate to severe stress in over half and some level of stress in nearly all COVID recovered individuals even after 3 months. Serum copeptin was found to be a useful biomarker to objectively measure stress in these subjects.
  • Apparent Treatment - Resistant Hypertension in Hypertensive Stroke Patients
    Journal International Medical Sciences Academy, 2022
  • Sars-cov-2 vaccines: A systematic review
    Journal of the Indian Medical Association, 2021
  • Physical Frailty Phenotype and Depression are Associated with More Severe Disease in Older Subjects Presenting with Acute Coronary Syndrome
    A Aggarwal, A Kumar, R Sharma, A Goel, R Kar, R Avasthi, AK Gupta
    Nigerian Journal of Clinical Practice, 2020
  • Correlation of lipid sub-fractions with atherosclerosis in Indian coronary artery disease patients
    Journal Indian Academy of Clinical Medicine, 2019
  • Isoniazid and rifampicin heteroresistant Mycobacterium tuberculosis isolated from tuberculous meningitis patients in India
    Renu Gupta, Rajeev Thakur, Suman Kushwaha, Nupur Jalan, Pumanshi Rawat, Piyush Gupta, Amitesh Aggarwal, Meena Gupta, Vikas Manchanda
    Indian Journal of Tuberculosis, 2018
  • Recurrent hypokalemia leading to flaccid quadriparesis: A renal or connective tissue disorder
    Puerto Rico Health Sciences Journal, 2017
  • Dyslipidaemia & oxidative stress in patients of psoriasis: Emerging cardiovascular risk factors
    Archana Singal, Kumari Asha, SumanBala Sharma, VinodKumar Arora, Amitesh Aggarwal
    Indian Journal of Medical Research, 2017
  • Predictors of adverse outcome in patients of tuberculous meningitis in a multi-centric study from India
    Renu Gupta, Suman Kushwaha, Rajeev Thakur, Nupur Jalan, Pumanshi Rawat, Piyush Gupta, Amitesh Aggarwal, Meena Gupta, Vikas Manchanda
    Indian Journal of Tuberculosis, 2017
  • Diffuse melanonychia as a clue to vitamin B12 deficiency
    Laxmikant Ramkumarsingh Tomar, Amit Kumar Dhawan, Sonal Sharma, Amitesh Aggarwal
    Tropical Doctor, 2016
  • Glycated apolipoprotein B - A surrogate marker of subclinical atherosclerosis
    Kapil Dev, Suman B. Sharma, Seema Garg, Amitesh Aggarwal, S.V. Madhu
    Diabetes and Metabolic Syndrome Clinical Research and Reviews, 2016
  • Nonketotic Hyperglycemia Presenting as Monoballism
    Amitesh Aggarwal, Nitin Bansal, Raghav Aggarwal
    Journal of Emergency Medicine, 2016
  • Missing diagnosis: Gingival hypertrophy due to amlodipine
    L.R. Tomar, A. Aggarwal
    Indian Heart Journal, 2015
  • An Unusual Presentation of Dengue Fever: Association with Longitudinal Extensive Transverse Myelitis
    Permanente Journal, 2015
  • Paroxysmal supraventricular tachycardia in hypothyroidism: A case report
    Laxmikant Ramkumarsingh Tomar, Sundaram Thondikulam Gopalakrishnan, Amitesh Aggarwal
    Journal of Cardiovascular Disease Research, 2015
  • Asymptomatic thoracic esophageal duplication cyst in a young adult with bronchiectasis
    Amitesh Aggarwal, LaxmikantRamkumarsingh Tomar, Velmurugan Mannar, Sonal Pruthi
    Lung India, 2015
  • Premature Graying of Hair: An Independent Risk Marker for Coronary Artery Disease in Smokers - A Retrospective Case Control Study
    A Aggarwal, S Srivastava, MP Agarwal, S Dwivedi
    Ethiopian Journal of Health Sciences, 2015
  • Splenic abscess: Plasmodium vivax with secondary Escherichia coli infection
    Laxmikant Ramkumarsingh Tomar, Ranjith Rajendran, Santosh Kumar Pandey, Amitesh Aggarwal
    Tropical Doctor, 2015
  • Acute viral hepatitis E presenting with haemolytic anaemia and acute renal failure in a patient with glucose-6-phosphate dehydrogenase deficiency
    Laxmikant Ramkumarsingh Tomar, Amitesh Aggarwal, Piyush Jain, Surender Rajpal, Mukul P Agarwal
    Tropical Doctor, 2015
  • Evaluation of geno type MTBD rplus line probe assay for early detection of drug resistance in tuberculous meningitis patients in India
    Renu Gupta, Rajeev Thakur, Prerna Gupta, Nupur Jalan, Suman Kushwaha, Meena Gupta, Piyush Gupta, Amitesh Aggarwal, Vikas Manchanda
    Journal of Global Infectious Diseases, 2015
  • Short-term mortality in acute coronary syndrome: Effect of dysglycaemia and smoking
    A. Aggarwal, A. Raoot, S. Srivastava, S. Dwivedi
    International Journal of Clinical Practice, 2014
  • Association of carotid intima-media thickness with leptin and apoliprotein b/apoliprotein a-I ratio reveals imminent predictors of subclinical atherosclerosis in psoriasis patients.
    Kumari Asha, Suman B. Sharma, Archana Singal, Amitesh Aggarwal
    Acta Medica Hradec Kralove Universitas Carolina Facultas Medica Hradec Kralove, 2014
  • Coronary artery disease: An Indian re?ection
    European Heart Journal, 2013
  • Why does an undergraduate student choose medicine as a career
    National Medical Journal of India, 2013
  • Heartburn literally: Cardiac injury due to corrosive ingestion
    V Sharma, A Aggarwal, A Bansal, A Dixit
    Journal of Postgraduate Medicine, 2013
  • Disaster management in India: A road ahead
    Sonal Pruthi, Amitesh Aggarwal, Ashish Goel
    Prehospital and Disaster Medicine, 2013
  • Role of family milieu in tobacco addiction: A study in a tertiary-care institution in India
    Shridhar Dwivedi, Amitesh Aggarwal, Nishant Singh, Sourabh Aggarwal, Vishal Sharma
    Journal of Health Population and Nutrition, 2013
  • All in the name of flavour, fragrance & freshness: Commonly used smokeless tobacco preparations in & around a tertiary hospital in India
    Indian Journal of Medical Research, 2012
  • Familial xanthelasma with dyslipidemia: Just another family trait?
    Amitesh Aggarwal, Safal Singh, Vishal Sharma, Shridhar Dwivedi
    North American Journal of Medical Sciences, 2012
  • Acute pancreatitis in a patient with vivax malaria
    Journal of the Pancreas, 2012
  • Newer antiatherosclerosis treatment strategies
    Amitesh Aggarwal, Safal Singh
    Heart Asia, 2011
  • Short Report: Cardiotoxicity from ‘safe’ herbomineral formulations
    Shridhar Dwivedi, Amitesh Aggarwal, Vishal Sharma
    Tropical Doctor, 2011
  • Cause of seizures: Lungs, not the brain
    Vishal Sharma, Amitesh Aggarwal, Surendra Rajpal, Shridhar Dwivedi
    Lung India, 2011
  • Adrenal insufficiency in primary adrenal lymphoma: Innocuous presentation of a rare sinister illness
    V Sharma, A Aggarwal, M Kotru, S Sharma
    Nigerian Journal of Clinical Practice, 2011
  • An uncommon infectious cause of pleural effusion
    Amitesh Aggarwal, Lokesh Champally Rajashekaraiah, Kiran Misra, Munish Dev, Vishal Sharma
    Tropical Doctor, 2011
  • Giant gluteal xanthomas
    S. Dwivedi, Amitesh Aggarwal, Vishal Sharma, Girish Dwivedi
    Circulation, 2010
  • The skin in general medicine
    Amitesh Aggarwal
    Clinical Medicine Journal of the Royal College of Physicians of London, 2010
  • The skin in general medicine
    Shridhar Dwivedi, Amitesh Aggarwal
    Clinical Medicine Journal of the Royal College of Physicians of London, 2010
  • Primary splenic hydatidosis in a 25-year-old man: A case report
    Amitesh Aggarwal, Vishal Sharma
    Cases Journal, 2009
  • Right ventricular endomyocardial fibrosis presenting with ventricular tachycardia and apical thrombus - An interesting presentation
    Indian Pacing and Electrophysiology Journal, 2009
  • Indigenous drugs in ischemic heart disease in patients with diabetes
    Shridhar Dwivedi, Amitesh Aggarwal
    Journal of Alternative and Complementary Medicine, 2009
  • Time line of cardiovascular continuum: Does it tick together in a subset of coronary artery disease
    Biomedicine, 2008
  • Cannabis smoking and acute coronary syndrome: Two illustrative cases
    Shridhar Dwivedi, Vivek Kumar, Amitesh Aggarwal
    International Journal of Cardiology, 2008
  • A young lady with hypotension and engorged neck veins
    A Aggarwal, V Sharma, MP Agarwal, S Giri
    Journal of Postgraduate Medicine, 2008
  • Acute severe poisoning by barium carbonate (rat poison)
    Journal Indian Academy of Clinical Medicine, 2008
  • Lipid profile of term infants on exclusive breastfeeding and mixed feeding: A comparative study
    D Harit, M M A Faridi, A Aggarwal, S B Sharma
    European Journal of Clinical Nutrition, 2008
  • Response to paper 'malignant ventricular arrhythmias due to aconitum napellus root'
    Indian Heart Journal, 2008
  • Acute myocardial infarction associated with carotid and left ventricular atherothrombosis: Clinical and preventive relevance
    Journal of Internal Medicine of India, 2007
  • Role of Terminalia arjuna in ischaemic mitral regurgitation
    S. Dwivedi, A. Aggarwal, M.P. Agarwal, S. Rajpal
    International Journal of Cardiology, 2005
  • Rupture of the Aneurysm of Sinus of Valsalva to the Right Ventricle
    Ultrasound International, 2003