Tukhieva Daria Vladislavovna

@irkgmu.ru

Department of Obstetrics and Gynecology with a course in Gynecology for children and adolescents
Irkutsk State Medical University of the Ministry of Health of Russia

Tukhieva Daria Vladislavovna


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https://researchid.co/d.glukhova2017

RESEARCH, TEACHING, or OTHER INTERESTS

Obstetrics and Gynecology
6

Scopus Publications

Scopus Publications

  • Simultaneous and staged surgeries in urological patients within an Enhanced Recovery After Surgery (ERAS) pathway: safety and efficacy evaluation
    A. R. Tukhiev, V. A. Vorobev, D. V. Tukhieva, K. M. Su-Yanz
    Vestnik Urologii Urology Herald, 2025
    Introduction. Combined surgical pathology poses a dilemma between simultaneous and staged approaches. Simultaneous surgeries, performed during a single anesthetic session, reduce hospitalization time, lower anesthetic burden, however, increased operative volume and duration may elevate the risk of complications. The staged approach reduces the immediate burden on the patient but requires multiple hospitalizations, prolongs overall treatment and recovery time. Objective. To compare clinical outcomes, length of hospitalization, postoperative complications and effectiveness of simultaneous versus staged urological surgeries within a structured enhanced recovery after surgery (ERAS) protocol. Materials & methods. A prospective single-center randomized study evaluating the safety of simultaneous and staged urological surgeries included 78 patients with combined urological and surgical pathologies, randomized into two groups. Compliance with the ERAS protocol above 80% was a criterion for inclusion in both groups. Group 1 (n = 53) underwent simultaneous surgeries, where multiple procedures were performed during a single operative session. Group 2 (n = 25) received staged treatment, with surgical interventions separated in time. Perioperative parameters, complication rates according to the Clavien-Dindo classification, length of hospitalization, patient-reported outcomes including postoperative pain assessed by the visual analog scale (VAS), requirement for opioid analgesics, intraoperative blood loss, total duration of urinary drainage, and cumulative surgical access size were evaluated. Results. Simultaneous surgeries demonstrated a significant reduction in overall hospitalization time (p < 0.01) and total operative time compared with staged interventions. No statistically significant differences in postoperative complication rates were observed between groups (p = 0.94). Conclusion. Both simultaneous and staged urological surgeries are safe approaches for patients with combined pathology. Simultaneous interventions offer advantages including reduced hospitalization time without increasing the risk of postoperative complications.
  • MATRIX METALLOPROTEINASES AND INFLAMMATION FACTORS IN WOMEN WITH PELVIC VARICOSE VEINS
    Klinichescheskaya Laboratornaya Diagnostika, 2025
  • Activity of NAD(P)-Dependent Dehydrogenases of Ovarian Vein Lymphocytes in Women with Pelvic Varicose Veins
    A. A. Semendyaev, M. A. Darenskaya, D. A. Stupin, S. I. Kolesnikov, N. V. Semenova, D. V. Tukhieva, L. I. Kolesnikova
    Bulletin of Experimental Biology and Medicine, 2024
  • Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women
    M. A. Darenskaya, A. A. Semendyaev, D. A. Stupin, S. I. Kolesnikov, N. V. Semenova, D. V. Tukhieva, A. V. Shcherbatykh, L. I. Kolesnikova
    Bulletin of Experimental Biology and Medicine, 2024
    The tissue preparations of the pelvic veins obtained during laparoscopy were examined. The expression of markers of proliferation (Ki-67), apoptosis (p53), and angiogenesis (CD31, CD34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohistochemical method. A decrease in the median expression of the proliferation marker (Ki-67) and estrogen and progesterone receptors and simultaneous increase in the expression of apoptosis marker (p53) and activation of angiogenesis processes (markers CD31 and CD34) were observed with increasing the severity of the disease. These data extend our understanding of the pathogenetic mechanisms of pelvic varicose veins and contribute to the development of methods of pathogenetically based targeted therapy.
  • Impact of Antioxidant Therapy on Lipid Peroxidation and Venous Hemodynamics in Women with Pelvic Venous Incompetence
    Marina A. Darenskaya, Dmitriy A. Stupin, Andrey A. Semendyaev, Sergey I. Kolesnikov, Daria V. Tukhieva, Lyubov I. Kolesnikova
    Biomedical Research and Therapy, 2024
    Introduction: Pelvic varicosity, a subset of pelvic venous incompetence (PVI), is considered a multifactorial, chronic disease with a progressive course. One effective therapeutic approach may be the use of drugs that inhibit oxidative stress (OS) reactions. The aim of this study was to evaluate the effect of an antioxidant complex on the state of the lipid peroxidation system and venous hemodynamic parameters in the treatment of patients with pelvic varicose veins. Methods: One hundred fifty patients with PVI were divided into two groups of seventy-five each, comparable in basic characteristics. Treatment for both groups included standard therapy with one of the venotropic drugs for 60 days. Additionally, the patients in the second group received an antioxidant complex application (ACA) for 30 days (one course), with a total of three courses over two months. Spectrophotometric and immunoenzymatic research methods were used. Results: In patients with PVI, the application of an antioxidant complex in combination with baseline venotropic therapy resulted in a statistically significant decrease in levels of LH, CDs, TBARs, and an increase in Catalase, SOD, GPO, GR, GST, and GSH after treatment. Additionally, there was an increase in blood flow velocity in varicose pelvic veins (iliac, ovarian, and arcuate), as well as a decrease in the duration of retrograde discharge to 0.3 cm. Conclusion: The use of antioxidant drugs (superoxide dismutase, acetyl glutathione, astaxanthin) in combination with venotropic therapy for the treatment of PVI significantly improves the indices of the lipid peroxidation-antioxidant defense system and venous hemodynamics in the pelvic organs of this patient cohort. The advantages of this complex treatment are evident both in comparison with the data before treatment and with the data from patients on venotropic therapy alone.
  • Clinical efficacy of complex antioxidant therapy for pelvic varicose veins in women: A prospective non-randomized controlled study
    Dmitry A. Stupin, Lyubov I. Kolesnikova, Andrey A. Semendyaev, Marina A. Darenskaya, Daria V. Tukhieva, Ekaterina S. Bystrova, Ksenia V. Kuryshova, Aleksandr I. Gus
    Gynecology, 2024
    Aim. To evaluate the clinical efficacy of complex antioxidant therapy (CAT) in the treatment of patients with pelvic varicose veins (PVV).Materials and methods. Patients with PVV (n=150) were divided into groups 1 and 2 of 75 subjects; the groups were comparable. Treatment in both groups included standard therapy with one of the venotropic agents (60 days). Patients of group 1 additionally received CAT for 30 days (1 course), in total 3 courses with 2-month intervals.Results. When assessing the parameters of the lipoperoxidation system (antioxidant protection) in group 1 during CAT combined with standard venotropic therapy, there was a statistically significant decrease in the levels of lipid hydroperoxides (p0.0001), diene conjugates (p=0.001), malonic dialdehyde (p0.0001), an increase in the levels of catalase (p0.0001), superoxide dismutase (p0.0001), glutathione peroxidase (p0.0001), glutathione reductase (p0.0001), glutathione-S-transferase (p=0.002) and the reduced glutathione content (p=0.032) compared to levels before treatment. The above group showed a decrease in the diameter of the pelvic varicose veins: internal iliac (p0.001), ovarian (p0.0001) and arcuate (p0.001), an increase in their blood flow velocity (p=0.003, 0.041, and 0.040, respectively), a decrease in the duration of retrograde flow to 0.3 cm. There was a decrease in pelvic pain (p0.0001), dysmenorrhea (p=0.024), dyspareunia (p=0.037), the frequency of irregular menstruation (p=0.031), an improvement in quality of life (p=0.047), pregnancy rate (p=0.013), the number of live births (p=0.004), and the duration of remission (p=0.047).Conclusion. The use of a combination of antioxidants superoxide dismutase 250 mg 2 times a day, acetyl-glutathione at 100 mg 2 times a day, and astaxanthin 400 mg/day for 30 days in 3 courses with 2-month intervals combined with venotropic therapy can significantly improve the treatment outcomes of patients with PVV.