Claudia Silva Marques

@cecaicetaup.wixsite.com

Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), Center for Study in Animal Science (CECA) - ICETA (University of Porto) and Instituto Nacional de Saúde Pública Dr. Ricardo Jorge - Porto

Claudia Silva Marques


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https://researchid.co/claudia.marques

RESEARCH, TEACHING, or OTHER INTERESTS

Parasitology, Cell Biology, Immunology, Animal Science and Zoology
29

Scopus Publications

1016

Scholar Citations

19

Scholar h-index

22

Scholar i10-index

Scopus Publications

  • An Experiment in Personalized Shopping for Optimal Health, with Integration of Nutrigenetics and Gut Microbiome Information
    Veronica Fernandes, Magalí Pezzarini, Yamile Márquez, Cláudia S. Marques, Facundo Ballesteros, Arnau Carmona, Priscila M. S. Delgado, Jéssica Fernández, Luciano Heitt, Darmit M. Kumar, Ana C. Magalhães, Nahuel Rosas, Keyvan Torabi, Marina Riera, Jean Pierre Lannou, Luisa Pereira
    Nutrients, 2026
    Background: An individual’s health status is determined by the interaction of genetic, environmental, social, and lifestyle variables. Nutrition plays a fundamental role in disease prevention, a notion widespread among the informed public, which is keen on participating in initiatives for personalized recommendations informed by advanced biological data. Objectives: To evaluate whether a personalized nutrition service can produce measurable changes in nutritional behavior and biological outcomes, we established the GENIE digital platform. This platform delivers personalized online food shopping and recipe recommendation informed by integrated data from (i) biochemical blood markers, (ii) nutrigenetic profiles, (iii) gut microbiota composition, and (iv) consumer preferences. Methods: We conducted a single-arm study in a Spanish cohort that used a specific online retailer for food shopping, totaling 1177 participants. Group 1 (n = 620) had recommendations based only on the biochemical blood test; Group 2 (n = 357) included the nutrigenetic test; and Group 3 had the gut microbiome test (first batch, n = 200; second batch, n = 97). After one month of informed, tailored dietary advice, a quantitative evaluation of the experience was conducted. Results: The GENIE platform led to strong engagement (mean session time 7.07 min; +154% e-commerce use), with 71% of participants following at least part of the recommendations. This was associated with an increase in microbiome diversity in about 70% of participants, after just one month of guided recommendations. Conclusions: The GENIE platform represents a pragmatic model for translating nutrigenetic and microbiome data into actionable dietary recommendations, bridging the gap between scientific evidence and consumer behavior.
  • Protozoa as the “Underdogs” for Microbiological Quality Evaluation of Fresh Vegetables
    Cláudia S. Marques, Susana Sousa, António Castro, Vânia Ferreira, Paula Teixeira, José M. Correia da Costa
    Applied Sciences Switzerland, 2022
    The monitoring of the microbial quality of fresh products in the industrial environment has mainly focused on bacterial indicators. Protozoa, such as Giardia duodenalis, Cryptosporidium spp., Toxoplasma gondii, and Cyclospora cayetanensis, are routinely excluded from detection and surveillance systems, despite guidelines and regulations that support the need for tracking and monitoring these pathogens in fresh food products. Previous studies performed by our laboratory, within the scope of the SafeConsume project, clearly indicated that consumption of fresh produce may be a source of T. gondii, thus posing a risk for the contraction of toxoplasmosis for susceptible consumers. Therefore, preliminary work was performed in order to assess the microbiological quality of vegetables, highlighting not only bacteria (Escherichia. coli, Listeria monocytogenes, and Salmonella spp.), but also the zoonotic protozoa G. duodenalis and Cryptosporidium spp. Although all samples were found to be acceptable based on bacteriological parameters, cysts of G. duodenalis and oocysts of Cryptosporidium spp. were observed in vegetables. Moreover, it was possible to genetically characterize G. duodenalis positive samples as assemblage A, a genotype that poses risks to human health. Although these are preliminary results, they highlight the need to include protozoa in the microbiological criteria for foodstuffs, as required by EU Law No. 1441/2007, and to improve inactivation and removal procedures of (oo)cysts in fresh produce and water.
  • The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review
    Sepideh Mahmoudzadeh, Hojjatollah Nozad Charoudeh, Cláudia Silva Marques, Saeed Bahadory, Ehsan Ahmadpour
    Parasitology Research, 2021
  • rTgOWP1-f, a specific biomarker for Toxoplasma gondii oocysts
    Susana Sousa, André Almeida, Lurdes Delgado, Antónia Conceição, Cláudia Marques, José Manuel Correia da Costa, António Castro
    Scientific Reports, 2020
    Toxoplasma gondii oocyst wall protein 1 (TgOWP1) integrates a family of seven proteins, consensually assumed as specific antigens of Toxoplasma gondii oocyst stage, located in the outer layer of the oocyst wall. Herein, we notice the expression of a recombinant antigen, rTgOWP1-f, derived from a fragment selected on basis of its structural homology with Plasmodium MSP1–19. Rabbit polyclonal antibodies anti-rTgOWP1-f evidence ability for specific identification of environmental T. gondii oocysts. We assume, rTgOWP1-f, as a possible biomarker of oocysts. In addition, we present findings supporting this vision, including the development of an immunodetection method for T. gondii oocysts identification.
  • Detection of Toxoplasma gondii oocysts in fresh vegetables and berry fruits
    Cláudia S. Marques, Susana Sousa, António Castro, José Manuel Correia da Costa
    Parasites and Vectors, 2020
    Background Toxoplasma gondii is the third most important contributor to health burden caused by food-borne illness. Ingestion of tissue cysts from undercooked meat is an important source of horizontal transmission to humans. However, there is an increasing awareness of the consumption of fresh fruit and vegetables, as a possible source for oocyst transmission, since this stage of the parasite can persist and remain infective in soil and water for long time. Herein, we outline findings related with detection of T. gondii oocysts in vegetables and berry fruits, which are usually raw consumed. The procedure includes the estimation of the number of oocysts. Methods Food samples were collected from local producers and supermarket suppliers. Toxoplasma gondii oocysts were concentrated after washing the samples by applying high resolution water filtration and immunomagnetic separation (method 1623.1: EPA 816-R-12-001-Jan 2012), in order to (i) remove potential Cryptosporidium spp. oocysts and Giardia spp. cysts present in the samples; and (ii) select T. gondii oocysts. Toxoplasma gondii oocyst detection and an estimation of their numbers was performed by conventional PCR and real time qPCR, using specific primers for a 183-bp sequence of the T. gondii repetitive DNA region. All PCR-positive DNA samples were purified and sequenced. Restriction enzyme digestion with EcoRV endonuclease confirmed the presence of the T. gondii DNA fragment. In addition, the presence of the parasite was observed by fluorescent microscopy, taking advantage of the oocysts autofluorescence under UV light. Results Forty percent of the analysed samples (95% CI: 25.5–56.5%) presented the expected PCR and digested DNA fragments. These fragments were confirmed by sequencing. Microscopic autofluorescence supported the presence of T. gondii-like oocysts. The estimated mean (± SE) oocyst concentration was 23.5 ± 12.1 oocysts/g, with a range of 0.6–179.9 oocysts/g. Conclusions Our findings provide relevant evidence of contamination of fresh vegetables and berry fruits with T. gondii oocysts.
  • In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives
    Honorina Cidade, Verónica Rocha, Andreia Palmeira, Cláudia Marques, Maria Elizabeth Tiritan, Helena Ferreira, José Sousa Lobo, Isabel Filipa Almeida, Maria Emília Sousa, Madalena Pinto
    Arabian Journal of Chemistry, 2020
    Many natural products play important roles as antioxidants and represent useful scaffolds for the development of new agents. Particularly, polyphenols in which oxygenated xanthones can be included have proven their efficacy as antioxidants for several applications. To better understand the antioxidant potential of oxygenated xanthones, a library of twenty mono and di-oxygenated xanthones was investigated. The antioxidant properties were evaluated by their 2,2-diphenyl-1-picrylhydrazyl (DPPH) and peroxyl radical scavenging effect as well as their inhibitory effect on the prooxidant enzyme myeloperoxidase (MPO). A quantitative structure-activity relationship (QSAR) model predicted the maximal atomic partial charge (Qmax) as the descriptor being implied in the antioxidant activity of the referred xanthones. From the antioxidant screening, emerged the hit compound, 1,2-dihydroxyxanthone (10), that was further characterized for its chelating properties and its effect on a human keratinocyte cell line. Taken together, the results suggest the possible effectiveness of xanthone derivatives as antioxidants with potential for topical administration.
  • A Plasmodium berghei sporozoite-based vaccination platform against human malaria
    António M. Mendes, Marta Machado, Nataniel Gonçalves-Rosa, Isaie J. Reuling, Lander Foquet, Cláudia Marques, Ahmed M. Salman, Annie S. P. Yang, Kara A. Moser, Ankit Dwivedi, Cornelus C. Hermsen, Belén Jiménez-Díaz, Sara Viera, Jorge M. Santos, Inês Albuquerque, Sangeeta N. Bhatia, John Bial, Iñigo Angulo-Barturen, Joana C. Silva, Geert Leroux-Roels, Chris J. Janse, Shahid M. Khan, Maria M. Mota, Robert W. Sauerwein, Miguel Prudêncio
    Npj Vaccines, 2018
    There is a pressing need for safe and highly effectivePlasmodium falciparum(Pf) malaria vaccines. The circumsporozoite protein (CS), expressed on sporozoites and during early hepatic stages, is a leading target vaccine candidate, but clinical efficacy has been modest so far. Conversely, whole-sporozoite (WSp) vaccines have consistently shown high levels of sterilizing immunity and constitute a promising approach to effective immunization against malaria. Here, we describe a novel WSp malaria vaccine that employs transgenic sporozoites of rodentP. berghei(Pb) parasites as cross-species immunizing agents and as platforms for expression and delivery ofPfCS (PbVac). We show that both wild-typePbandPbVac sporozoites unabatedly infect and develop in human hepatocytes while unable to establish an infection in human red blood cells. In a rabbit model, similarly susceptible toPbhepatic but not blood infection, we show thatPbVac elicits cross-species cellular immune responses, as well asPfCS-specific antibodies that efficiently inhibitPfsporozoite liver invasion in human hepatocytes and in mice with humanized livers. Thus,PbVac is safe and induces functional immune responses in preclinical studies, warranting clinical testing and development.
  • Potential benefits of a sulfated resveratroderivative for topical application
    Marta Correia-da-Silva, Verónica Rocha, Cláudia Marques, Cláudia M Deus, Adriana Marques-Carvalho, Paulo J Oliveira, Andreia Palmeira, Madalena Pinto, Emília Sousa, José Manuel Sousa Lobo, Isabel Filipa Almeida
    Journal of Molecular Endocrinology, 2018
    Resveratrol (RSV) is a polyphenolic compound with antioxidant, anti-inflammatory and anti-aging properties partly associated with sirtuin 1 (SIRT1)-activation in the skin. However, poor water solubility may limit RSV efficacy. This work aimed to clarify the interest of a new synthetic water-soluble RSV derivative (resveratrol glucoside sulfate, RSV-GS) for topical application. Resveratrol glucoside sulfate was synthesized using microwave-assisted sulfation. Cytotoxicity assays were performed with the keratinocyte HaCaT cell line, using MTT reduction, neutral red uptake, Alamar Blue/resazurin reduction, trypan blue exclusion and measurement of ATP concentration. Western blotting was used to evaluate SIRT1 protein content. Regarding SIRT1 binding, anin silicodocking study was performed, using AutoDock Vina. Our results showed that the synthetic derivative RSV-GS was 1000 times more soluble in water than RSV and its non-sulfated glucoside. No relevant decrease in HaCaT cell viability was observed for concentrations up to 5 mM for RSV-GS, and up to 500 μM for resveratrol glucoside, while a significant decrease in HaCaT viability occurred from 100 μM for RSV. RSV-GS and RSV showed a similar behavior regarding protective effect against oxidative stress-induced cytotoxicity. SIRT1 protein content increased after treatment with 500 μM of RSV-GS and 100 μM of RSV. Moreover,in silicostudies predicted that RSV-GS binds more stably to SIRT1 with a lower binding free energy than RSV. Although these results support the possible use of RSV-GS in topical formulations,in vivosafety and efficacy studies are needed before considering the use of RSV-GS in commercial products.
  • CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors
    Cláudia S. Marques, Ana Rita Santos, Andreia Gameiro, Jorge Correia, Fernando Ferreira
    BMC Cancer, 2018
    BACKGROUND: The receptor CXCR4 and its ligand CXCL12 play crucial roles in breast cancer. Despite the fact that the spontaneous feline mammary carcinoma (FMC) is considered a suitable model for breast cancer studies, the importance of the CXCR4/CXCL12 axis in FMC is completely unknown. Therefore, this work aims to elucidate the role of CXCR4 and its ligand in the progression of FMC and metastatic disease. METHODS: CXCR4 and CXCL12 expression was analyzed by immunohistochemistry and immunofluorescence on primary tumors (PT), regional and distant metastases of female cats with mammary carcinoma and correlated with serum CXCL12 levels, tumor molecular subtypes and clinicopathological features. RESULTS: CXCR4 was more expressed in PT than in metastases (p = 0.0067), whereas CXCL12 was highly expressed in metastatic lesions located in liver and lung (p < 0.0001), as reported for human breast cancer. Moreover, cats with CXCR4 positive PT exhibited significantly lower serum CXCL12 levels than cats with CXCR4 negative mammary carcinomas (p = 0.0324). At metastatic lesions, HER2-overexpressing tumors presented higher CXCR4 expression than the other molecular tumor subtypes (p = 0.012) and significant differences in overall (p = 0.0147) and disease-free survival (p = 0.0279) curves between the cats with CXCL12 positive and CXCL12 negative tumors were found. Indeed, CXCL12 negative PT were associated with unfavorable prognosis in cats with HER2-overexpressing tumors. CONCLUSIONS: This work exposes part of the complex interaction between CXCR4 and CXCL12 in PT, but also in metastases of a breast cancer model. These findings could uncover novel therapeutic tools to be used in cats and humans.
  • In vitro cytotoxicity evaluation of resveratrol-loaded nanoparticles: Focus on the challenges of in vitro methodologies
    V. Rocha, C. Marques, J.L. Figueiredo, A.R. Gaio, P.C. Costa, J.M. Sousa Lobo, I.F. Almeida
    Food and Chemical Toxicology, 2017
  • Serum SDF-1 levels are a reliable diagnostic marker of feline mammary carcinoma, discriminating HER2-overexpressing tumors from other subtypes
    Cláudia S. Marques, Maria Soares, Ana Santos, Jorge Correia, Fernando Ferreira
    Oncotarget, 2017
  • HER2-positive feline mammary carcinoma
    Cláudia Marques, Jorge Correia, Fernando Ferreira
    Aging, 2016
  • Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders
    I. M. Carvalho, P. B. Coelho, P. C. Costa, C. S. Marques, R. S. Oliveira, D. C. Ferreira
    Neuromolecular Medicine, 2015
  • New insights into neutrophil and Leishmania infantum in vitro immune interactions
    Cláudia S. Marques, Luiz Felipe D. Passero, Inês Vale-Gato, Armanda Rodrigues, Olivia Roos Rodrigues, Catarina Martins, Ivone Correia, Ana M. Tomás, Graça Alexandre-Pires, M. Helena Ferronha, Gabriela M. Santos-Gomes
    Comparative Immunology Microbiology and Infectious Diseases, 2015
  • Influence of glioma cells on a new co-culture in vitro blood-brain barrier model for characterization and validation of permeability
    Bárbara Mendes, Cláudia Marques, Isabel Carvalho, Paulo Costa, Susana Martins, Domingos Ferreira, Bruno Sarmento
    International Journal of Pharmaceutics, 2015
  • Sustained drug release by contact lenses for glaucoma treatment - A review
    I.M. Carvalho, C.S. Marques, R.S. Oliveira, P.B. Coelho, P.C. Costa, D.C. Ferreira
    Journal of Controlled Release, 2015
  • Immunization with the Leishmania infantum recombinant cyclophilin protein 1 confers partial protection to subsequent parasite infection and generates specific memory T cells
    G.M. Santos-Gomes, A. Rodrigues, F. Teixeira, J. Carreira, G. Alexandre-Pires, S. Carvalho, D. Santos-Mateus, C. Martins, I. Vale-Gato, C. Marques, A.M. Tomás
    Vaccine, 2014
  • Tissue regulation of somitic colloid-like1 gene expression
    Tomas Pais de Azevedo, Vanessa Zuzarte-Luís, Lisa Gonçalves, Claudia Marques, Isabel Palmeirim
    Biochemical and Biophysical Research Communications, 2012
  • Analysis of the protective potential of antigens released by Leishmania (Viannia) shawi promastigotes
    Luiz Felipe Domingues Passero, Cláudia Marques, Inês Vale-Gato, Carlos Eduardo Pereira Corbett, Márcia Dalastra Laurenti, Gabriela Santos-Gomes
    Archives of Dermatological Research, 2012
  • Cytokine Gene Expression in the Tissues of Dogs Infected by Leishmania infantum
    M.A.G. Barbosa, G. Alexandre-Pires, M. Soares-Clemente, C. Marques, O. Roos Rodrigues, T. Villa De Brito, I. Pereira Da Fonseca, L.C. Alves, G.M. Santos-Gomes
    Journal of Comparative Pathology, 2011
  • Histopathology, humoral and cellular immune response in the murine model of Leishmania (Viannia) shawi
    Luiz Felipe Domingues Passero, Cláudia Marques, Inês Vale-Gato, Carlos Eduardo Pereira Corbett, Márcia Dalastra Laurenti, Gabriela Santos-Gomes
    Parasitology International, 2010
  • Identification of regulatory T cells during experimental Leishmania infantum infection
    Olivia Roos Rodrigues, Cláudia Marques, Marta Soares-Clemente, Maria Helena Ferronha, Gabriela Maria Santos-Gomes
    Immunobiology, 2009
  • Differential expression of cytokine genes among sickle-cell-trait (HbAS) and normal (HbAA) children infected with Plasmodium falciparum
    D. A. Hassan, C. Marques, G. M. Santos-Gomes, V. E. do Rosario, H. S. Mohamed, A. M. Elhussein, M. E. Ibrahim, N. H. Abdulhadi
    Annals of Tropical Medicine and Parasitology, 2009
  • Efficacy of the liposome trifluralin in the treatment of experimental canine leishmaniosis
    C. Marques, M. Carvalheiro, M.A. Pereira, J. Jorge, M.E.M. Cruz, G.M. Santos-Gomes
    Veterinary Journal, 2008
  • Immunization with Leishmania infantum released proteins confers partial protection against parasite infection with a predominant Th1 specific immune response
    Ricardo Rosa, Cláudia Marques, Olivia Roos Rodrigues, Gabriela M. Santos-Gomes
    Vaccine, 2007
  • Intra-specific variability of virulence in Leishmania infantum zymodeme MON-1 strains
    Teresa Baptista-Fernandes, Cláudia Marques, Olivia Roos Rodrigues, Gabriela Maria Santos-Gomes
    Comparative Immunology Microbiology and Infectious Diseases, 2007
  • Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
    Ricardo Rosa, Cláudia Marques, Olivia Roos Rodrigues, Gabriela M. Santos-Gomes
    Acta Tropica, 2006
  • Leishmania infantum: Soluble proteins released by the parasite exert differential effects on host immune response
    R. Rosa, O. Roos Rodrigues, C. Marques, G.M. Santos-Gomes
    Experimental Parasitology, 2005
  • Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: Interferon-γ and interleukin-4 mRNA expression
    Cláudia S Marques, Nuno Rolão, Sónia Centeno-Lima, Hélder Lousada, Carla Maia, Lenea Campino, Virgílio E do Rosário, Henrique Silveira
    Memorias do Instituto Oswaldo Cruz, 2005

RECENT SCHOLAR PUBLICATIONS

  • An Experiment in Personalized Shopping for Optimal Health, with Integration of Nutrigenetics and Gut Microbiome Information
    Nutrients 18 , 2026
    2026
  • Protozoa as the “Underdogs” for Microbiological Quality Evaluation of Fresh Vegetables
    CS Marques, S Sousa, A Castro, V Ferreira, P Teixeira, JMC da Costa
    Applied Sciences 12 (14), 7145 , 2022
    2022
    Citations: 4
  • The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review
    S Mahmoudzadeh, H Nozad Charoudeh, CS Marques, S Bahadory, ...
    Parasitology Research 120 (7), 2303-2309 , 2021
    2021
    Citations: 50
  • Detection of Toxoplasma gondii oocysts in fresh vegetables and berry fruits
    CS Marques, S Sousa, A Castro, JMC da Costa
    Parasites & Vectors 13 (1), 1-12 , 2020
    2020
    Citations: 67
  • rTgOWP1-f, a specific biomarker for Toxoplasma gondii oocysts
    S Sousa, A Almeida, L Delgado, A Conceição, C Marques, JMC da Costa, ...
    Scientific Reports 10 (1), 1-8 , 2020
    2020
    Citations: 5
  • In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives
    H Cidade, V Rocha, A Palmeira, C Marques, ME Tiritan, H Ferreira, ...
    Arabian Journal of Chemistry 13 (1), 17-26 , 2020
    2020
    Citations: 50
  • CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors
    CS Marques, AR Santos, A Gameiro, J Correia, F Ferreira
    BMC cancer 18 (1), 741 , 2018
    2018
    Citations: 28
  • A Plasmodium berghei sporozoite-based vaccination platform against human malaria
    AM Mendes, M Machado, N Gonçalves-Rosa, IJ Reuling, L Foquet, ...
    npj Vaccines 3 (1), 1-11 , 2018
    2018
    Citations: 42
  • SULFATION PATHWAYS: Potential benefits of a sulfated resveratrol derivative for topical application
    M Correia-da-Silva, V Rocha, C Marques, CM Deus, A Marques-Carvalho, ...
    Journal of molecular endocrinology 61 (2), M27-M39 , 2018
    2018
    Citations: 11
  • Serum SDF-1 levels are a reliable diagnostic marker of feline mammary carcinoma, discriminating HER2-overexpressing tumors from other subtypes
    CS Marques, M Soares, A Santos, J Correia, F Ferreira
    Oncotarget 8 (62), 105775 , 2017
    2017
    Citations: 21
  • In vitro cytotoxicity evaluation of resveratrol-loaded nanoparticles: Focus on the challenges of in vitro methodologies
    V Rocha, C Marques, JL Figueiredo, AR Gaio, PC Costa, JMS Lobo, ...
    Food and Chemical Toxicology 103, 214-222 , 2017
    2017
    Citations: 30
  • HER2-positive feline mammary carcinoma
    FF Marques C, Correia J
    Aging 8, 1574-1575 , 2016
    2016
    Citations: 11
  • Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders
    FDC Carvalho IM, Coelho PB, Costa PC, Marques CS, Oliveira RS
    NeuroMolecular Medicine 17, 404-422 , 2015
    2015
    Citations: 19
  • Influence of glioma cells on a new co-culture in vitro blood–brain barrier model for characterization and validation of permeability
    B Mendes, C Marques, I Carvalho, P Costa, S Martins, D Ferreira, ...
    International journal of pharmaceutics 490 (1), 94-101 , 2015
    2015
    Citations: 55
  • New insights into neutrophil and Leishmania infantum in vitro immune interactions
    CS Marques, LFD Passero, I Vale-Gato, A Rodrigues, OR Rodrigues, ...
    Comparative immunology, microbiology and infectious diseases 40, 19-29 , 2015
    2015
    Citations: 29
  • Sustained drug release by contact lenses for glaucoma treatment-A review.
    FDC Carvalho IM, Marques CS, Oliveira RS, Coelho PB, Costa PC
    Journal of Controlled Release 202, 76-82 , 2015
    2015
    Citations: 205
  • Immunization with the Leishmania infantum recombinant cyclophilin protein 1 confers partial protection to subsequent parasite infection and generates specific memory T cells
    GM Santos-Gomes, A Rodrigues, F Teixeira, J Carreira, ...
    Vaccine 32 (11), 1247-1253 , 2014
    2014
    Citations: 28
  • Role of neutrophils in parasite persistence and in host immunity during the initial phase of Leishmania chagasi experimental infection
    CS Marques, S Falcão, F Novais, DM Santos, A Rodrigues, LF Passero, ...
    Frontiers in Immunology , 2013
    2013
    Citations: 2
  • Tissue regulation of somitic colloid-like1 gene expression
    TP de Azevedo, V Zuzarte-Luís, L Gonçalves, C Marques, I Palmeirim
    Biochemical and biophysical research communications 424 (2), 295-300 , 2012
    2012
    Citations: 2
  • Analysis of the protective potential of antigens released by Leishmania (Viannia) shawi promastigotes
    LFD Passero, C Marques, I Vale-Gato, CEP Corbett, MD Laurenti, ...
    Archives of dermatological research 304 (1), 47-55 , 2012
    2012
    Citations: 5

MOST CITED SCHOLAR PUBLICATIONS

  • Sustained drug release by contact lenses for glaucoma treatment-A review.
    FDC Carvalho IM, Marques CS, Oliveira RS, Coelho PB, Costa PC
    Journal of Controlled Release 202, 76-82 , 2015
    2015
    Citations: 205
  • Identification of regulatory T cells during experimental Leishmania infantum infection
    OR Rodrigues, C Marques, M Soares-Clemente, MH Ferronha, ...
    Immunobiology 214 (2), 101-111 , 2009
    2009
    Citations: 109
  • Detection of Toxoplasma gondii oocysts in fresh vegetables and berry fruits
    CS Marques, S Sousa, A Castro, JMC da Costa
    Parasites & Vectors 13 (1), 1-12 , 2020
    2020
    Citations: 67
  • Influence of glioma cells on a new co-culture in vitro blood–brain barrier model for characterization and validation of permeability
    B Mendes, C Marques, I Carvalho, P Costa, S Martins, D Ferreira, ...
    International journal of pharmaceutics 490 (1), 94-101 , 2015
    2015
    Citations: 55
  • Cytokine gene expression in the tissues of dogs infected by Leishmania infantum
    MAG Barbosa, G Alexandre-Pires, M Soares-Clemente, C Marques, ...
    Journal of comparative pathology 145 (4), 336-344 , 2011
    2011
    Citations: 51
  • The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review
    S Mahmoudzadeh, H Nozad Charoudeh, CS Marques, S Bahadory, ...
    Parasitology Research 120 (7), 2303-2309 , 2021
    2021
    Citations: 50
  • In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives
    H Cidade, V Rocha, A Palmeira, C Marques, ME Tiritan, H Ferreira, ...
    Arabian Journal of Chemistry 13 (1), 17-26 , 2020
    2020
    Citations: 50
  • A Plasmodium berghei sporozoite-based vaccination platform against human malaria
    AM Mendes, M Machado, N Gonçalves-Rosa, IJ Reuling, L Foquet, ...
    npj Vaccines 3 (1), 1-11 , 2018
    2018
    Citations: 42
  • Intra-specific variability of virulence in Leishmania infantum zymodeme MON-1 strains
    T Baptista-Fernandes, C Marques, OR Rodrigues, GM Santos-Gomes
    Comparative immunology, microbiology and infectious diseases 30 (1), 41-53 , 2007
    2007
    Citations: 37
  • Immunization with Leishmania infantum released proteins confers partial protection against parasite infection with a predominant Th1 specific immune response
    R Rosa, C Marques, OR Rodrigues, GM Santos-Gomes
    Vaccine 25 (23), 4525-4532 , 2007
    2007
    Citations: 35
  • Efficacy of the liposome trifluralin in the treatment of experimental canine leishmaniosis
    C Marques, M Carvalheiro, MA Pereira, J Jorge, MEM Cruz, ...
    The Veterinary Journal 178 (1), 133-137 , 2008
    2008
    Citations: 34
  • Leishmania infantum: soluble proteins released by the parasite exert differential effects on host immune response
    R Rosa, OR Rodrigues, C Marques, GM Santos-Gomes
    Experimental parasitology 109 (2), 106-114 , 2005
    2005
    Citations: 34
  • In vitro cytotoxicity evaluation of resveratrol-loaded nanoparticles: Focus on the challenges of in vitro methodologies
    V Rocha, C Marques, JL Figueiredo, AR Gaio, PC Costa, JMS Lobo, ...
    Food and Chemical Toxicology 103, 214-222 , 2017
    2017
    Citations: 30
  • Histopathology, humoral and cellular immune response in the murine model of Leishmania (Viannia) shawi
    LFD Passero, C Marques, I Vale-Gato, CEP Corbett, MD Laurenti, ...
    Parasitology international 59 (2), 159-165 , 2010
    2010
    Citations: 30
  • New insights into neutrophil and Leishmania infantum in vitro immune interactions
    CS Marques, LFD Passero, I Vale-Gato, A Rodrigues, OR Rodrigues, ...
    Comparative immunology, microbiology and infectious diseases 40, 19-29 , 2015
    2015
    Citations: 29
  • CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors
    CS Marques, AR Santos, A Gameiro, J Correia, F Ferreira
    BMC cancer 18 (1), 741 , 2018
    2018
    Citations: 28
  • Immunization with the Leishmania infantum recombinant cyclophilin protein 1 confers partial protection to subsequent parasite infection and generates specific memory T cells
    GM Santos-Gomes, A Rodrigues, F Teixeira, J Carreira, ...
    Vaccine 32 (11), 1247-1253 , 2014
    2014
    Citations: 28
  • Serum SDF-1 levels are a reliable diagnostic marker of feline mammary carcinoma, discriminating HER2-overexpressing tumors from other subtypes
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