CORAUX Christelle
@univ-reims.fr
Scopus Publications
- Electrolyte-rich saline solutions significantly improve nasal epithelial repair, ciliary beating and epithelial inflammation vs. normal saline
Ludovic de Gabory, Christelle Coraux, Anne Beaulieu, Mélodie Kerimian
European Archives of Oto Rhino Laryngology, 2026 - Peptide CIGB-552 has a synergistic effect on CFTR-F508del when combined with elexacaftor/tezacaftor/ivacaftor triple therapy for cystic fibrosis
Benjamin Simonneau, Stéphanie Simon, Bénédicte Duriez, Aurélie Guguin, Frédéric Becq, Sandra Mirval, Christelle Coraux, Fanny Degrugillier, Bruno Costes, Maribel G. Vallespi, Pascale Fanen, Abdel Aissat
British Journal of Pharmacology, 2025
Background and PurposeCystic fibrosis is an autosomal recessive disease caused by mutations in the CFTR gene, leading to progressive respiratory decline and reduced life expectancy. The most common mutation, CFTR‐F508del, results in mislocalised and non‐functional protein. Although triple therapy with elexacaftor/tezacaftor/ivacaftor (ETI) is prescribed for patients carrying this mutation, some biological defects remain unresolved. We previously identified COMMD1 as a potential therapeutic target, as its overexpression enhances CFTR‐WT plasma membrane localisation. CIGB‐552, a cell‐penetrating peptide discovered in 2013, stabilises COMMD1. This study evaluates its therapeutic potential in cystic fibrosis.Experimental ApproachCIGB‐552 was tested, with and without ETI, in CFBE and HEK cells stably expressing CFTR‐WT or CFTR‐F508del, and in primary human bronchial cells. CFTR function was assessed using YFP quenching and short‐circuit current assays. Peptide uptake was evaluated using FITC‐labelled CIGB‐552 in submerged and air–liquid interface models. Plasma membrane density of CFTR was measured in CFBE CFTR‐HA cells, and western blotting assessed CFTR maturation and COMMD1 expression.Key resultsCIGB‐552 was non‐toxic and preferentially entered CFBE CFTR‐F508del cells rather than CFBE CFTR‐WT cells, without altering COMMD1 expression or localisation. Although not a corrector or potentiator alone, CIGB‐552 synergised with ETI, enhancing CFTR‐F508del‐mediated chloride efflux, confirmed in primary cells. CIGB‐552 also increased YFP quenching of CFTR‐WT and CFTR‐G551D, in combination with ivacaftor. This effect required COMMD1.Conclusions and ImplicationsCOMMD1 expression was necessary for CIGB‐552 to affect CFTR function positively. Its synergy with the triple therapy offers a promising strategy for improving CF treatment. - Low-molecular-weight hyaluronic acid improves regeneration of cystic fibrosis airway epithelium
Damien Adam, Emilie Luczka-Majérus, Julie Cellier, Charline Dos Santos-Dietz, Claire Kileztky, Arnaud Bonnomet, Christophe Ruaux, Edouard Sage, Myriam Polette, Michel Abély, Christelle Coraux
Erj Open Research, 2025
Background Cystic fibrosis is characterised by defective mucociliary clearance, chronic lung infection and exaggerated neutrophilic inflammation. Airway epithelium damage and remodelling affect lung defence functions and are therefore important components of lung pathology progression in cystic fibrosis. Identifying compounds that favour mucociliary clearance by improving airway epithelial structure and regeneration is therefore crucial for patients with cystic fibrosis. Materials and methods Using air–liquid interface culture of human airway epithelial cells obtained from patients with cystic fibrosis, we examined the influence of low-molecular-weight hyaluronic acid (LMW-HA) (∼40 kDa) on the regeneration and remodelling of cystic fibrosis human airway epithelial cells. Results Our results show that LMW-HA normalises cystic fibrosis epithelial regeneration, even in an inflamed environment, by preventing remodelling in terms of epithelial height and basal cell hyperplasia, by avoiding inflammation-related goblet cell hyperplasia and by stimulating multiciliated cell differentiation. Because remodelling is mainly due to either intrinsic inflammation of cystic fibrosis human airway epithelial cells or an extrinsic inflammatory environment, we examined the impact of LMW‑HA on epithelial interleukin 8 pro-inflammatory chemokine and found that it exerts an anti-inflammatory effect, evidenced by reduced epithelial interleukin 8 expression and secretion. Conclusion We report here that LMW-HA prevents cystic fibrosis human airway epithelial cell remodelling and normalises its cell structure, probably through the epithelial cell inflammatory phenotype modulation, and improves multiciliated cell differentiation by a mechanism that is independent of its anti-inflammatory effect. These results demonstrate that LMW-HA should be considered as a therapeutic candidate for the treatment of cystic fibrosis lung disease. - Roscovitine enhances the bactericidal activity of the airway surface liquid of the cystic fibrosis bronchial epithelium but does not protect against Pseudomonas aeruginosa infection
Adrien Maupas, Anaëlle Muggeo, Pierre Vermeulen, Sophie Moussalih, Edouard Sage, Emilie Luczka-Majérus, Christelle Coraux, Thomas Guillard
Plos One, 2025
Cystic fibrosis (CF) is the most common genetic diseases in the Caucasian population. CFTR defects, the most common being F508del, lead to abnormal mucus accumulation. Respiratory failure caused by the resulting chronic infections is the leading cause of death in people with cystic fibrosis (pwCF). Pseudomonas aeruginosa is a major pathogen in CF and is responsible for a deterioration of respiratory function in pwCF. The increase of antibiotic-resistant P. aeruginosa strains encourages the search for alternative therapeutics for treating P. aeruginosa infection. In vitro studies have shown an interest in (R)-roscovitine (roscovitine) in the fight against bacterial infection in pwCF. Here we show a nuanced effect of roscovitine on ASL bactericidal activity and CF bronchial epithelium protection against P. aeruginosa. Using a 3D model of fully differentiated and functional F508del-CFTR human bronchial epithelium, we evidenced (i) an enhancement of the bactericidal activity of the airway surface liquid for 25 μM roscovitine but (ii) no limitation of the dynamic of the epithelium destruction upon roscovitine treatment whatever the concentrations. Our findings shed light on reasons for the lack of beneficial effects to prevent P. aeruginosa infection in pwCF treated with roscovitine in the ROSCO-CF clinical trial. We anticipate that our findings would have significant therapeutic implications in seeking to optimize roscovitine analogs. - The F508del-CFTR trafficking correctors elexacaftor and tezacaftor are CFTR-independent Ca2+-mobilizing agonists normalizing abnormal Ca2+ levels in human airway epithelial cells
Manuella Lévêque, Sandra Mirval, Christine Barrault, Isabelle Fixe, Christelle Coraux, Edouard Sage, Frédéric Becq, Clarisse Vandebrouck
Respiratory Research, 2024
BACKGROUND: Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) channel. For people with CF (pwCF) affected by the most common pathogenic variant F508del, a tritherapy, named Trikafta/Kaftrio (ETI: elexacaftor (VX-445) /tezacaftor (VX-661) / ivacaftor (VX-770)) was successfully developed. However, in CF airway epithelial cells the calcium homeostasis is also disturbed; it is observed an increased calcium mobilization in CF cells compared to non-CF cells. Here, we studied the effects of ETI on intracellular calcium levels in F508del-CFTR airway epithelial cells to determine whether these compounds, individually or collectively, could normalize intracellular calcium levels. METHODS: We measured intracellular calcium variations using human airway epithelial cells (hAEC) from pwCF, human bronchial epithelial CFBE41o- F508del-CFTR cells and Chinese Hamster Ovary (CHO) cells using the fluorescent probe Fluo4-AM, in the presence or absence of extracellular calcium. The rescue to the plasma membrane of F508del-CFTR protein by ETI was determined by western blot. The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA), was also analysed by western blotting and by interference assay. RESULTS: We show that ETI normalizes calcium homeostasis in our cellular models. However, we also found that (1) each ETI-corrector compound is capable of mobilizing calcium acutely in the absence of CFTR, and (2) tezacaftor mobilizes calcium from the endoplasmic reticulum (ER) probably via inhibition of the SERCA pump. CONCLUSIONS: We show that ETI not only corrects the abnormal trafficking and function of F508del-CFTR but also normalizes calcium homeostasis in our cellular models. Finally, we identified SERCA as a potential intracellular target for tezacaftor. - The Inhibition of the Membrane-Bound Transcription Factor Site-1 Protease (MBTP1) Alleviates the p.Phe508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Defects in Cystic Fibrosis Cells
Raphaël Santinelli, Nathalie Benz, Julie Guellec, Fabien Quinquis, Ervin Kocas, Johan Thomas, Tristan Montier, Chandran Ka, Emilie Luczka-Majérus, Edouard Sage, Claude Férec, Christelle Coraux, Pascal Trouvé
Cells, 2024
Cystic Fibrosis (CF) is present due to mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, the most frequent variant being p.phe508del. The CFTR protein is a chloride (Cl-) channel which is defective and almost absent of cell membranes when the p.Phe508del mutation is present. The p.Phe508del-CFTR protein is retained in the endoplasmic reticulum (ER) and together with inflammation and infection triggers the Unfolded Protein Response (UPR). During the UPR, the Activating Transcription Factor 6 (ATF6) is activated with cleavage and then decreases the expression of p.Phe508del-CFTR. We have previously shown that the inhibition of the activation of ATF6 alleviates the p.Phe508del-CFTR defects in cells overexpressing the mutated protein. In the present paper, our aim was to inhibit the cleavage of ATF6, and thus its activation in a human bronchial cell line with endogenous p.Phe508del-CFTR expression and in bronchial cells from patients, to be more relevant to CF. This was achieved by inhibiting the protease MBTP1 which is responsible for the cleavage of ATF6. We show here that this inhibition leads to increased mRNA and p.Phe508del-CFTR expression and, consequently, to increased Cl-efflux. We also explain the mechanisms linked to these increases with the modulation of genes when MBTP1 is inhibited. Indeed, RT-qPCR assays show that genes such as HSPA1B, CEBPB, VIMP, PFND2, MAPK8, XBP1, INSIG1, and CALR are modulated. In conclusion, we show that the inhibition of MBTP1 has a beneficial effect in relevant models to CF and that this is due to the modulation of genes involved in the disease. - IL-20 Cytokines Are Involved in the Repair of Airway Epithelial Barrier: Implication in Exposure to Cigarette Smoke and in COPD Pathology
Olivia Barada, Sophie Salomé-Desnoulez, Fahima Madouri, Gaëtan Deslée, Christelle Coraux, Philippe Gosset, Muriel Pichavant
Cells, 2023
Background: Dysregulated inflammation as seen in chronic obstructive pulmonary disease (COPD) is associated with impaired wound healing. IL-20 cytokines are known to be involved in wound healing processes. The purpose of this study was to use ex vivo and in vitro approaches mimicking COPD to evaluate the potential modulatory role of interleukin-20 (IL-20) on the inflammatory and healing responses to epithelial wounding. Methods: The expression of IL-20 cytokines and their receptors was investigated in lung-derived samples collected from non-COPD and COPD patients, from mice chronically exposed to cigarette smoke and from airway epithelial cells from humans and mice exposed in vitro to cigarette smoke. To investigate the role of IL-20 cytokines in wound healing, experiments were performed using a blocking anti-IL-20Rb antibody. Results: Of interest, IL-20 cytokines and their receptors were expressed in bronchial mucosa, especially on airway epithelial cells. Their expression correlated with the disease severity. Blocking these cytokines in a COPD context improved the repair processes after a lesion induced by scratching the epithelial layer. Conclusions: Collectively, this study highlights the implication of IL-20 cytokines in the repair of the airway epithelium and in the pathology of COPD. IL-20 subfamily cytokines might provide therapeutic benefit for patients with COPD to improve epithelial healing. - Current concepts on Pseudomonas aeruginosa interaction with human airway epithelium
Anaëlle Muggeo, Christelle Coraux, Thomas Guillard
Plos Pathogens, 2023
Pseudomonas aeruginosa is a major, but opportunistic, respiratory pathogen, which rarely infects healthy individuals, mainly due to the barrier effect of the human airway epithelium (HAE). This review explores the interaction of P. aeruginosa with HAE and the progression of the infection. The basolateral part of the epithelium, which includes the basolateral membrane of the epithelial cells and the basement membrane, is inaccessible in normal tight epithelia with intact junctions. We highlight how P. aeruginosa exploits weaknesses in the HAE barrier to gain access to the basolateral part of the epithelium. This access is crucial to initiate respiratory infection and is mainly observed in the injured epithelium, in repairing or chronically remodeled epithelium, and during extrusion of senescent cells or cell multiplication during normal epithelium renewal. The subsequent adhesion of the bacteria and cytotoxic action of virulence factors, including the toxins delivered by the type 3 secretion system (T3SS), lead to retractions and cell death. Eventually, P. aeruginosa progressively reaches the basement membrane and propagates radially through the basal part of the epithelium to disseminate using twitching and flagellar motility. - Involvement of inorganic phosphate starvation in Pseudomonas aeruginosa bacterial virulence
L. Jahdauti, A. Muggeo, V. Paturel, S. Jaisson, E. Luczka, C. Coraux, T. Guillard
Revue Des Maladies Respiratoires, 2023 - Ciliogenesis is intrinsically altered in COPD small airways
Emilie Luczka-Majérus, Arnaud Bonnomet, Adeline Germain, Nathalie Lalun, Claire Kileztky, Jeanne-Marie Perotin, Gaëtan Deslée, Gonzague Delepine, Myriam Polette, Valérian Dormoy, Christelle Coraux
European Respiratory Journal, 2022
COPD is characterised by a progressive and irreversible airflow limitation due to airway obstruction and emphysema [1]. We and others showed that bronchial epithelial remodelling in COPD is characterised by alteration of ciliogenesis and cilia function [2, 3], as well as a dysregulation of non-motile primary cilia (PC) [4]. In COPD, the main site of obstruction is in the small airways [5]. Considering that COPD is foremost a small airway disease (SAD) [6–8], we investigated the differentiation of bronchiolar epithelium in COPD, focusing on motile and primary ciliogenesis. An alteration of primary and motile ciliogenesis is detected in mild/moderate COPD small airways and could be at the origin of the initiation of epithelial remodelling http://bit.ly/3Tz3JDj - Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity
Antony Hoarau, Myriam Polette, Christelle Coraux
Biomolecules, 2022 - The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor
Frédéric Becq, Sandra Mirval, Thomas Carrez, Manuella Lévêque, Arnaud Billet, Christelle Coraux, Edouard Sage, Anne Cantereau
European Respiratory Journal, 2022 - Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells
Lionel Froux, Christelle Coraux, Edouard Sage, Frédéric Becq
Scientific Reports, 2019 - Involvement of the Prion Protein in the Protection of the Human Bronchial Epithelial Barrier Against Oxidative Stress
Amal Kouadri, Mariam El Khatib, Johanna Cormenier, Sylvain Chauvet, Wael Zeinyeh, Micheline El Khoury, Laurence Macari, Pierre Richaud, Christelle Coraux, Isabelle Michaud-Soret, Nadia Alfaidy, Mohamed Benharouga
Antioxidants and Redox Signaling, 2019 - Inactivation of the interleukin-22 pathway in the airways of cystic fibrosis patients
Antoine Guillon, Deborah Brea, Emilie Luczka, Virginie Hervé, Soujoud Hasanat, Camille Thorey, Magdiel Pérez-Cruz, Juliette Hordeaux, Julie Mankikian, Philippe Gosset, Christelle Coraux, Mustapha Si-Tahar
Cytokine, 2019 - Alteration of primary cilia in COPD
Jeanne-Marie Perotin, Christelle Coraux, Eymeric Lagonotte, Philippe Birembaut, Gonzague Delepine, Myriam Polette, Gaëtan Deslée, Valérian Dormoy
European Respiratory Journal, 2018 - MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
Florence Sonneville, Manon Ruffin, Christelle Coraux, Nathalie Rousselet, Philippe Le Rouzic, Sabine Blouquit-Laye, Harriet Corvol, Olivier Tabary
Nature Communications, 2017 - Buserelin alleviates chloride transport defect in human cystic fibrosis nasal epithelial cells
Marie-Laure Calvez, Nathalie Benz, Florentin Huguet, Aude Saint-Pierre, Elise Rouillé, Christelle Coraux, Claude Férec, Mathieu Kerbiriou, Pascal Trouvé
Plos One, 2017 - Non-diluted seawater enhances nasal ciliary beat frequency and wound repair speed compared to diluted seawater and normal saline
Arnaud Bonnomet, Emilie Luczka, Christelle Coraux, Ludovic de Gabory
International Forum of Allergy and Rhinology, 2016 - In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis
Clémence O. Henry, Emilie Dalloneau, Maria-Teresa Pérez-Berezo, Cristina Plata, Yongzheng Wu, Antoine Guillon, Eric Morello, Rose-France Aimar, Marie Potier-Cartereau, Frédéric Esnard, Christelle Coraux, Christian Börnchen, Rainer Kiefmann, Christophe Vandier, Lhousseine Touqui, Miguel A. Valverde, Nicolas Cenac, Mustapha Si-Tahar
American Journal of Physiology Lung Cellular and Molecular Physiology, 2016 - Cystic fibrosis airway epithelium remodelling: Involvement of inflammation
Damien Adam, Jacqueline Roux-Delrieu, Emilie Luczka, Arnaud Bonnomet, Julien Lesage, Jean-Claude Mérol, Myriam Polette, Michel Abély, Christelle Coraux
Journal of Pathology, 2015 - Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity
Jeanne-Marie Perotin, Damien Adam, Juliette Vella-Boucaud, Gonzague Delepine, Sebastian Sandu, Anne-Carole Jonvel, Alain Prevost, Gérard Berthiot, Christophe Pison, François Lebargy, Philippe Birembaut, Christelle Coraux, Gaëtan Deslee
Respiratory Research, 2014 - Regeneration of airway epithelium
D. Adam, J.-M. Perotin, F. Lebargy, P. Birembaut, G. Deslée, C. Coraux
Revue Des Maladies Respiratoires, 2014 - Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure
Kamel Maouche, Kahina Medjber, Jean-Marie Zahm, Franck Delavoie, Christine Terryn, Christelle Coraux, Stéphanie Pons, Isabelle Cloëz-Tayarani, Uwe Maskos, Philippe Birembaut, Jean-Marie Tournier
Proceedings of the National Academy of Sciences of the United States of America, 2013 - Improvement of defective cystic fibrosis airway epithelial wound repair after CFTR rescue
Nguyen Thu Ngan Trinh, Olivier Bardou, Anik Privé, Emilie Maillé, Damien Adam, Sarah Lingée, Pasquale Ferraro, Martin-Yvon Desrosiers, Christelle Coraux, Emmanuelle Brochiero
European Respiratory Journal, 2012 - Modification of macroporous titanium tracheal implants with biodegradable structures: Tracking in vivo integration for determination of optimal in situ epithelialization conditions
Nihal Engin Vrana, Agnes Dupret-Bories, Charlotte Bach, Christophe Chaubaroux, Christelle Coraux, Dominique Vautier, Fouzia Boulmedais, Youssef Haikel, Christian Debry, Marie-Helene Metz-Boutigue, Philippe Lavalle
Biotechnology and Bioengineering, 2012 - Impact of microRNA in normal and pathological respiratory epithelia.
Lisa Giovannini-Chami, Nathalie Grandvaux, Laure-Emmanuelle Zaragosi, Karine Robbe-Sermesant, Brice Marcet, Bruno Cardinaud, Christelle Coraux, Yves Berthiaume, Rainer Waldmann, Bernard Mari, Pascal Barbry
Methods in Molecular Biology Clifton N J, 2011 - MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation
Brice Marcet, Benoît Chevalier, Christelle Coraux, Laurent Kodjabachian, Pascal Barbry
Cell Cycle, 2011 - The effect of hyaluronan on airway mucus transport and airway epithelial barrier integrity: Potential application to the cytoprotection of airway tissue
Jean-Marie Zahm, Magali Milliot, Anthony Bresin, Christelle Coraux, Philippe Birembaut
Matrix Biology, 2011 - MicroDNA control biosynthesis of motile cilia in vertebrates
Benoît Chevalier, Laurent Kodjabachian, Christelle Coraux, Pascal Barbry, Brice Marcet
Medecine Sciences, 2011 - Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
Brice Marcet, Benoît Chevalier, Guillaume Luxardi, Christelle Coraux, Laure-Emmanuelle Zaragosi, Marie Cibois, Karine Robbe-Sermesant, Thomas Jolly, Bruno Cardinaud, Chimène Moreilhon, Lisa Giovannini-Chami, Béatrice Nawrocki-Raby, Philippe Birembaut, Rainer Waldmann, Laurent Kodjabachian, Pascal Barbry
Nature Cell Biology, 2011 - Hybrid titanium/biodegradable polymer implants with an hierarchical pore structure as a means to control selective cell movement
Nihal Engin Vrana, Agnès Dupret, Christelle Coraux, Dominique Vautier, Christian Debry, Philippe Lavalle
Plos One, 2011 - Long acting β2-agonist and corticosteroid restore airway glandular cell function altered by bacterial supernatant
Jean-Marie Zahm, Franck Delavoie, Férial Toumi, Béatrice Nawrocki-Raby, Claire Kileztky, Jean Michel, Gérard Balossier, Malcolm Johnson, Christelle Coraux, Philippe Birembaut
Respiratory Research, 2010 - Salmeterol restores secretory functions in cystic fibrosis airway submucosal gland serous cells
Franck Delavoie, Michael Molinari, Magali Milliot, Jean-Marie Zahm, Christelle Coraux, Jean Michel, Gérard Balossier
American Journal of Respiratory Cell and Molecular Biology, 2009 - Video-microscopic imaging of cell spatio-temporal dispersion and migration
Christine Terryn, Arnaud Bonnomet, Jérôme Cutrona, Christelle Coraux, Jean-Marie Tournier, Béatrice Nawrocki-Raby, Myriam Polette, Philippe Birembaut, Jean-Marie Zahm
Critical Reviews in Oncology Hematology, 2009 - α7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation
Kamel Maouche, Myriam Polette, Thomas Jolly, Kahina Medjber, Isabelle Cloëz-Tayarani, Jean-Pierre Changeux, Henriette Burlet, Christine Terryn, Christelle Coraux, Jean-Marie Zahm, Philippe Birembaut, Jean-Marie Tournier
American Journal of Pathology, 2009 - Epithelial cell-extracellular matrix interactions and stem cells in airway epithelial regeneration
Christelle Coraux, Jacqueline Roux, Thomas Jolly, Philippe Birembaut
Proceedings of the American Thoracic Society, 2008 - Airway Epithelial Defence, Repair and Regeneration
Christelle Coraux, Jean‐Marie Tournier, Jean‐Marie Zahm, Edith Puchelle
Chronic Obstructive Pulmonary Disease, 2008 - Feasibility of nasal epithelial brushing for the study of airway epithelial functions in CF infants
Katharina Mosler, Christelle Coraux, Konstantina Fragaki, Jean-Marie Zahm, Odile Bajolet, Katia Bessaci-Kabouya, Edith Puchelle, Michel Abély, Pierre Mauran
Journal of Cystic Fibrosis, 2008 - Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation
Marie Skowron-zwarg, Sonja Boland, Nathalie Caruso, Christelle Coraux, Francelyne Marano, Frédéric Tournier
Experimental Cell Research, 2007 - Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation
Pierre LeSimple, Isabelle van Seuningen, Marie-Pierre Buisine, Marie-Christine Copin, Margitta Hinz, Werner Hoffmann, Rodolphe Hajj, Steven L. Brody, Christelle Coraux, Edith Puchelle
American Journal of Respiratory Cell and Molecular Biology, 2007 - Human airway surface epithelial regeneration is delayed and abnormal in cystic fibrosis
R Hajj, P Lesimple, B Nawrocki‐Raby, P Birembaut, E Puchelle, C Coraux
Journal of Pathology, 2007 - Basal cells of the human adult airway surface epithelium retain transit-amplifying cell properties
Rodolphe Hajj, Thomas Baranek, Richard Le Naour, Pierre Lesimple, Edith Puchelle, Christelle Coraux
Stem Cells, 2007 - Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease
Edith Puchelle, Jean-Marie Zahm, Jean-Marie Tournier, Christelle Coraux
Proceedings of the American Thoracic Society, 2006 - Regeneration of injured airway epithelium
E. Puchelle, P. Le Simple, R. Hajj, Ch. Coraux
Annales Pharmaceutiques Francaises, 2006 - α3α5β2-nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells
Jean-Marie Tournier, Kamel Maouche, Christelle Coraux, Jean-Marie Zahm, Isabelle Cloëz-Tayarani, Béatrice Nawrocki-Raby, Arnaud Bonnomet, Henriette Burlet, François Lebargy, Myriam Polette, Philippe Birembaut
American Journal of Pathology, 2006 - In vivo models of human airway epithelium repair and regeneration
C. Coraux, R. Hajj, P. Lesimple, E. Puchelle
European Respiratory Review, 2005 - Differential expression of matrix metalloproteinases and interleukin-8 during regeneration of human airway epithelium in vivo
Christelle Coraux, Corinne Martinella‐Catusse, Béatrice Nawrocki‐Raby, Rodolphe Hajj, Henriette Burlet, Sandie Escotte, Véronique Laplace, Philippe Birembaut, Edith Puchelle
Journal of Pathology, 2005 - Embryonic stem cells generate airway epithelial tissue
Christelle Coraux, Béatrice Nawrocki-Raby, Jocelyne Hinnrasky, Claire Kileztky, Dominique Gaillard, Christian Dani, Edith Puchelle
American Journal of Respiratory Cell and Molecular Biology, 2005 - Repair and regeneration of the airway epithelium
Christelle Coraux, Rodolphe Hajj, Pierre Lesimple, Edith Puchelle
Medecine Sciences, 2005 - Reconstitution of human airway tissue in the humanized xenograft model
Sandie Escotte, Corinne Catusse, Christelle Coraux, Edith Puchelle
Journal of Cystic Fibrosis, 2004 - Regeneration of a well-differentiated human airway surface epithelium by spheroid and lentivirus vector-transduced airway cells
Nicolas Castillon, Aurélie Avril‐Delplanque, Christelle Coraux, Christophe Delenda, Bruno Péault, Olivier Danos, Edith Puchelle
Journal of Gene Medicine, 2004 - Airway epithelial integrity is protected by a long-acting β2-adrenergic receptor agonist
Christelle Coraux, Claire Kileztky, Myriam Polette, Jocelyne Hinnrasky, Jean-Marie Zahm, Philippe Devillier, Sophie de Bentzmann, Edith Puchelle
American Journal of Respiratory Cell and Molecular Biology, 2004 - Reconstituted skin from murine embryonic stem cells
Christelle Coraux, Caroline Hilmi, Matthieu Rouleau, Anne Spadafora, Jocelyne Hinnrasky, Jean-Paul Ortonne, Christian Dani, Daniel Aberdam
Current Biology, 2003 - Distribution of laminin 5, integrin receptors, and branching morphogenesis during human fetal lung development
Christelle Coraux, Guerrino Meneguzzi, Patricia Rousselle, Edith Puchelle, Dominique Gaillard
Developmental Dynamics, 2002 - Binding of USF to a non-canonical E-box following stress results in a cell-specific derepression of the lama3 gene
T. Virolle
Nucleic Acids Research, 2002 - Contribution of MT1-MMP and of human laminin-5 γ2 chain degradation to mammary epithelial cell migration
Christine Gilles, Myriam Polette, Christelle Coraux, Jean-Marie Tournier, Guerrino Meneguzzi, Carine Munaut, Laure Volders, Patricia Rousselle, Philippe Birembaut, Jean-Michel Foidart
Journal of Cell Science, 2001 - Epithelial stem cell-mediated development of the human respiratory mucosa in SCID mice
Journal of Cell Science, 2000 - β1-Integrins are involved in migration of human fetal tracheal epithelial cells and tubular morphogenesis
Christelle Coraux, Jean-Marie Zahm, Edith Puchelle, Dominique Gaillard
American Journal of Physiology Lung Cellular and Molecular Physiology, 2000 - Modified basement membrane composition during bronchopulmonary tumor progression
Corinne Catusse, Myriam Polette, Christelle Coraux, Henriette Burlet, Philippe Birembaut
Journal of Histochemistry and Cytochemistry, 2000 - Distribution of integrins during human fetal lung development
Christelle Coraux, Aurélie Delplanque, Jocelyne Hinnrasky, Bruno Peault, Edith Puchelle, Dominique Gaillard
Journal of Histochemistry and Cytochemistry, 1998
