Pharmacology (medical), Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Toxicology
47
Scopus Publications
905
Scholar Citations
16
Scholar h-index
23
Scholar i10-index
Scopus Publications
2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity Rodrigo Santos Aquino de Araújo, Vitória Gaspar Bernardo, Robert da Silva Tibúrcio, Danilo Cesar Galindo Bedor, Michel Leandro de Campos, Roberto Pontarolo, Julyanne Maria Saraiva de Sousa, Klinger Antonio da Franca Rodrigues, Marcus Tullius Scotti, Anuraj Nayarisseri, Pascal Marchand, Francisco Jaime Bezerra Mendonça-Junior Pharmaceuticals, 2025 Background/Objectives: Leishmaniasis is one of the 20 Neglected Tropical Diseases according to the WHO, affecting approximately 12 million people in four continents, generating serious public health problems. The lack of therapeutic options, associated with toxicity and the emergence of resistance to the few available drugs, makes it urgent to develop new drug options. In this context, the aims of this work are to expand the knowledge about the pharmacophore group responsible for the antileishmanial potential of 2-aminothiophene derivatives. Thus, new compounds were synthesized containing chemical modifications at the C-3, C-4, and C-5 positions of the 2-aminothiophene ring, in addition to the S-Se bioisosterism. Methods: Dozens of 2-AT and 2-aminoselenophen (2-AS) derivatives were sequentially synthesized through applications of the Gewald reaction and were then evaluated in vitro for their activities against L. amazonensis and for cytotoxicity against macrophages. Results: Several series of compounds were synthesized, and it was possible to identify some substitution patterns favorable to the activity generating compounds with IC50 values below 10 µM, such as the non-essentiality of the presence of a carbonitrile group at C-3; the importance of the presence and size of cycloalkyl/piperidinyl chains at C-4 and C-5 in modulating the activity; and the increase in activity without affecting the safety of the S/Se bioisosteric substitution. Conclusions: Taken together, these findings reaffirm the great potential of 2-aminothiophenes to generate antileishmanial drug candidates and offers contributions to the drug design of compounds with an even more promising profile for the problem of leishmaniasis.
Pharmacokinetics of oral ciprofloxacin in adult patients: A scoping review Allan Michael Junkert, Raul Edison Luna Lazo, Flávia Deffert, Jaqueline Carneiro, Helena Hiemisch Lobo Borba, Michel Leandro de Campos, Roberto Pontarolo British Journal of Clinical Pharmacology, 2024 AimsTo map the literature on oral ciprofloxacin's pharmacokinetics and its implications for dose adjustments in specific populations.MethodsA scoping review was performed according to the Cochrane Collaboration and JBI and reported following the PRISMA‐ScR. Systematic searches on electronic databases were conducted to integrate the current evidence on ciprofloxacin's pharmacokinetics. The quality of the included studies was assessed using ClinPK's checklist.ResultsThe search yielded 55 relevant studies. Within the traditional pharmacokinetics studies (n = 46), 86 profiles were examined (72 involving healthy patients and 14 with various clinical conditions). Oral ciprofloxacin's pharmacokinetics were influenced by covariates such as drug interactions (ferrous ions, calcium carbonate, diclofenac and itraconazole), food interactions (calcium‐rich foods), elderly populations and renal impairment. Notably, variability in pharmacokinetic parameters existed among subjects, regardless of their health status, underscoring the need for comprehensive population descriptions. Population pharmacokinetic studies (n = 9) identified significant covariates for hospitalized patients, such as creatinine clearance, plasma bicarbonate, estimated glomerular filtration rate, renal replacement therapy, age, sex, total bilirubin, fat‐free mass, dietary factors in renal disease, rifampicin for clearance models and body weight for volume of distribution models. Most pharmacokinetic/pharmacodynamic assessments concluded that 1200 mg/day provides a high probability of target attainment for bacteria with minimum inhibitory concentration <0.5 mg L−1, aiming for an area under the curve for 24 h/minimum inhibitory concentration >125 h.ConclusionsThis study offers a comprehensive overview regarding oral ciprofloxacin's pharmacokinetics across various health conditions. It highlights the complexities of ciprofloxacin's pharmacokinetics, emphasizing the importance of considering multiple factors in dose adjustments.
Pharmacokinetic Profile of Metformin and SGLT2 Inhibitors alone and in Combination: a Pharmacokinetic Study in Wistar Rats Mariana Millan Fachi, Bruna Carolina Lui Dias, Jonata Augusto de Oliveria, Rosângela Gonçalves Peccinini, Roberto Pontarolo, Michel Leandro de Campos Journal of Applied Bioanalysis, 2023 Objective: To achieve glycemic control, a combination of drugs is eventually necessary, especially the dual therapy of SGLT2 inhibitors with metformin. Despite the value of combination therapy, understanding the pharmacokinetic properties is critical. Therefore, this study aimed to conduct the combined and isolated administration of hypoglycemic drugs to understand their pharmacokinetic properties. Methodology: The study was performed by gavage in twenty-five rats that were divided into five groups: metformin alone (60 mg/kg), canagliflozin alone 20 mg/kg, canagliflozin and metformin (20 mg/kg and 60 mg/kg, respectively), dapagliflozin alone 2 mg/kg, and dapagliflozin and metformin (2 mg/kg and 60 mg/kg, respectively). Blood samples were collected between 0.25 and 36 hours postdose and quantified by an HPLC-MS/MS method. Results: The metformin pharmacokinetics showed values lower than those from literature, but the most relevant result was a significant change in Cmax (3400 ng/mL), AUC (872.4 ng.min/L) and CL/F (72 mL/min/kg) in the metformin with dapagliflozin group compared to metformin alone Cmax (523 ng/mL), AUC (106.8 ng.min/L) and CL/F (752 mL/min/kg). For canagliflozin, the Cmax of 6116.7 ng/mL observed in our study was similar to that observed in literature, while the clearance (5.1 mL/min/kg) was higher than that of literature, which was 3.5 mL/min/kg. Clearance of dapagliflozin CL/F was reported as 3.33 mL/min/kg, while our result was 4.6 mL/min/kg. The same study also published dapagliflozin half-life and MRT, which were slightly lower than our findings. In general, the parameters of canagliflozin and dapagliflozin were similar to the literature and did not change with simultaneous administration with metformin. Conclusion: Dapagliflozin significantly changed the pharmacokinetic disposition of metformin, while metformin coadministration had no influence on the pharmacokinetics of SGLT2 inhibitors
Plasma and erythocyte magnesium levels: from validation of the method to analysis in volunteers diagnosed to migraine Marcio Tadashi Hoshino, Matheus Gomes Bochio, Juliandra Spagnol Bonache, Larissa Ludwig, Michel Leandro de Campos, G. Emerick Magnesium Research, 2022 Deficiency of serum magnesium is associated with the incidence of migraine attacks. The present study aimed to evaluate plasma and erythrocyte magnesium levels in a group of patients diagnosed with migraine. Human donors were selected from basic health units (migraine, n = 25) and from a collection and transfusion unit (control, n = 25), both located in the city of Sinop, Brazil. Plasma and erythrocyte magnesium were assessed using flame atomic absorption. Plasma magnesium concentration was significantly lower in the migraine group (0.172 ± 0.018) compared to the control group (0.197 ± 0.020 mg/L), and erythrocyte magnesium concentration was also lower in the migraine group (0.393 ± 0.053 mg/L) compared to the control group (0.432 ± 0.056 mg/L). The method for analysis of magnesium in human plasma and erythrocytes by flame atomic absorption was shown to be in accordance with validation guidelines. This study shows that plasma and erythrocyte magnesium levels were significantly lower in volunteers diagnosed with migraine compared to healthy volunteers. Furthermore, erythrocyte magnesium proved to be a better marker than plasma magnesium for patients with migraine.
Pharmacokinetics of isoniazid in Wistar rats exposed to ethanol Taísa Busaranho Franchin, Jonata Augusto de Oliveira, Caroline Damico Candido, Evelin dos Santos Martins, Elias Carvalho Padilha, Michel Leandro de Campos, Rosângela Gonçalves Peccinini Brazilian Journal of Pharmaceutical Sciences, 2022 Tuberculosis treatment consists of a drug combination, where isoniazid is the core drug and alcoholism is a factor highly related to poor patient compliance with the therapy. CYP2E1 is an enzyme involved both in the metabolism of ethanol and in the formation of hepatotoxic compounds during the metabolism of isoniazid. The shared metabolism pathway accounts for the possibility of pharmacokinetic interaction in cases of concomitant alcohol use during tuberculosis treatment. The aim of this study was to evaluate the effect of repeated exposure of Wistar rats (males, 250 g, n=6) to ethanol on the pharmacokinetics of a single dose of isoniazid in combination with pyrazinamide and rifampicin (100 mg/kg, 350 mg/kg and 100 mg/kg, respectively). An animal group received the combination of drugs and ethanol and was compared to a control group, which received the combination of drugs without exposure to ethanol. The plasma concentrations of isoniazid were determined by a UHPLC/UV bioanalytical method that was previously validated. Biochemical markers of liver function were measured to assess potential damage. A lower elimination half-life of isoniazid was observed in the ethanol group than in the control group (t1/2 0.91 h versus 1.34 h). There was no evidence of hepatotoxicity through the biomarker enzymes evaluated. The results allow us to infer that although there are no biochemical changes related to liver damage, there is a slight influence of ethanol exposure on the pharmacokinetic profile of isoniazid. This change may have a relevant impact on the efficacy of isoniazid in the outcome of tuberculosis treatment.
In vitro metabolism of copalic and kaurenoic acids in rat and human liver microsomes Mariana Mauro, Rodrigo Silva, Michel Campos, Anelize Bauermeister, Norberto Lopes, Natalia Moraes Quimica Nova, 2021 Copalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to characterize the metabolism of CA and KA in rat and human liver microsomes using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The in vitro assays showed deviations from the Michaelian kinetics in the metabolism of CA and KA. Putative metabolites of CA and KA were characterized by LC-MS/MS using electrospray ionization (ESI) with time of flight (LC-ESI-TOF) and ion-trap (LC-ESI-IT) systems and identified as a CA isomer and 16,17-dihydroxy-kaurenoic acid, respectively. CA and KA are subject to extensive metabolism with each passage through the liver with extraction ratios (E) estimated as 0.97 and 0.99, respectively. In conclusion, the kinetic parameters and metabolites described here might support drug development and the traditional use.
Ceftriaxone and methicillin-susceptible staphylococcus aureus: a perspective from pharmacokinetics/pharmacodynamics studies Joao Paulo Telles, Rodrigo Cuiabano Paes Leme, Michel Leandro Campos, Carmen Ito, Larissa Bail, Keite Da Silva Nogueira, Felipe Francisco Tuon Expert Opinion on Drug Metabolism and Toxicology, 2021 Introduction: Usage of ceftriaxone-based therapy to treat Methicillin-Susceptible Staphylococcus aureus (MSSA) infections is a controversial issue, from in vitro to clinical studies. Area covered: We conducted a literature review using PubMed of articles with ceftriaxone pharmacokinetics parameters and built a probability of target attainment (PTA) based on PK values from stable conditions (non-critically-ill patients) with goals of fT>55%, fT>75%, and fT>100%. Ceftriaxone’s minimal inhibitory concentration from 31 MSSA strains (0.25–64 mg/L) was used to build the cumulative fraction response (CFR). The isolates were clinically relevant from blood, bronchoalveolar lavage, and soft tissue biopsy. Expert opinion: The results from controversies about using ceftriaxone for MSSA infections have been commonly addressed in the literature. However, variables such as (i) pharmacokinetic profile, (ii) pharmacodynamic target, (iii) site of infection, and (iv) MIC distributions may influence divergences. From this pharmacokinetics-pharmacodynamics perspective, ceftriaxone may be a reasonable option for MSSA infections when the MIC50 and MIC90 were 4 mg/L and 8 mg/L. CFR analysis demonstrated that ceftriaxone 1 g q24 h could be used if bacteriostasis is the aim (fT>55%), while 1 g q12h should be used for bactericidal effects (fT>75% or fT>100%). These dosing regimens should be considered in other clinical trials.
New Validated Method for Quantification of Glycated Hemoglobin by LC-QToF-MS: Is HRMS Able to Quantify Clinical Samples? Letícia Bonancio Cerqueira, Mariana Millan Fachi, Wilton Hideki Kawagushi, Flavia Lada Degaut Pontes, Michel Leandro de Campos, Roberto Pontarolo Journal of the American Society for Mass Spectrometry, 2020 High-resolution mass spectrometry is a powerful tool in clinical analysis but remains less explored due to its lower dynamic range and sensitivity than triple quadrupoles. Glycated hemoglobin (HbA1c) is the current gold standard biomarker to monitor the control of diabetes, representing long-term plasma glycemic levels. Due to its clinical importance, several methods have been developed for HbA1c quantification, using different principles; however, the results obtained with these techniques may differ according to the method adopted. Hence, there is a great need to standardize the current methods to quantify glycated hemoglobin. A new UPLC-QToF-MS method was fully validated and tested to quantify HbA1c in human samples. The peptides VHLTPE m/z 695.373 and gly-VHLTPE m/z 857.426, obtained via Glu-C digestion, were the selected peptides for quantification of HbA1c (mmol/mol). Chromatographic separation was obtained in a C18 column, maintained at 40 °C. The mobile phase was composed of water and acetonitrile, both containing 0.02% TFA and 0.1% acetic acid, and eluted in gradient mode. The method was fully validated, being considered linear in the range of 25 mmol/mol to 107 mmol/mol of HbA1c, and was sensitive, selective, precise, accurate and free of matrix and carryover effects. The method was successfully applied to real samples, reaching about 90% agreement with reference method results, providing accurate and precise information on peptide mass, without laborious sample preparation. These results support the use of HRMS to improve the quality of quantitative results of HbA1c in health services and demonstrate a possible application of peptide investigation for clinical analysis in the near future.
In vivo and in vitro anti-inflammatory and pro-osteogenic effects of citrus cystatin CsinCPI-2 Natalia Da Ponte Leguizamón, Elisandra Marcia Rodrigues, Michel Leandro de Campos, Andressa Vilas Boas Nogueira, Kennia Scapin Viola, Vanessa Karine Schneider, Daniela Morilha Neo-Justino, Mario Tanomaru-Filho, Willian Fernando Zambuzzi, Flavio Henrique-Silva, Andrea Soares-Costa, Gisele Faria, Joni Augusto Cirelli Cytokine, 2019
Design, synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent Michelle de Oliveira Pedrosa Rolim, Anderson Rodrigues de Almeida, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Lucindo José Quintans-Júnior, Jullyana de Souza Siqueira Quintans, Luana Heimfarth, Luciana Scotti, Marcus Tullius Scotti, Ryldene Marques Duarte da Cruz, Reinaldo Nóbrega de Almeida, Teresinha Gonçalves da Silva, Jonata Augusto de Oliveira, Michel Leandro de Campos, Pascal Marchand, Francisco Jaime Bezerra Mendonça-Junior International Immunopharmacology, 2019
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses Juliana de Moura Alonso, Thiago Yukio Nitta, Tatiana Yumi Mizucina Akutagawa, Amanda Paulino Crescencio, Regina Kiomi Takahira, Bruna dos Santos, Ana Liz Garcia Alves, Marcos Jun Watanabe, Celso Antônio Rodrigues, Rosangela Gonçalves Peccinini, Michel Leandro de Campos, Carlos Alberto Hussni Journal of Equine Veterinary Science, 2017
Implementation of in vitro metabolism studies: Comparison of NADPH addition and NADPH regenerating system Revista De Ciencias Farmaceuticas Basica E Aplicada, 2017
Application of the in vitro metabolic stability assay in the evaluation of drug candidates Revista De Ciencias Farmaceuticas Basica E Aplicada, 2017
Biocompatible microemulsion modifies the tissue distribution of doxorubicin Caroline Damico Candido, Michel Leandro Campos, Juliana Uruguay Correa Vidigal Assumpção, Kelly Chrystina Pestana, Elias Carvalho Padilha, Iracilda Zeppone Carlos, Rosângela Gonçalves Peccinini Journal of Pharmaceutical Sciences, 2014
Evaluation of antimalarial activity and toxicity of a new primaquine prodrug Marcelo Gomes Davanço, Anna Caroline Campos Aguiar, Leandro Alves dos Santos, Elias Carvalho Padilha, Michel Leandro Campos, Cleverton Roberto de Andrade, Luiz Marcos da Fonseca, Jean Leandro dos Santos, Chung Man Chin, Antoniana Ursine Krettli, Rosangela Gonçalves Peccinini Plos One, 2014
Compounded oral doxycycline in late-term pregnant mares: pharmacokinetics, fetoplacental diffusion, and neonatal safety FT D’el Rey Dantas, IF Canisso, LS Feijó, PMF de Vasconselos, ... Theriogenology, 117783 , 2025 2025
2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity RSA de Araújo, VG Bernardo, RS Tibúrcio, DCG Bedor, ML Campos, ... Pharmaceuticals 18 (1), 125 , 2025 2025 Citations: 7
Development and validation of a new method by MIR-FTIR and chemometrics for the early diagnosis of leprosy and evaluation of the treatment effect AC Novack, A de Fátima Cobre, DP Stremel, LM Ferreira, ML Campos, ... Chemometrics and Intelligent Laboratory Systems 254, 105248 , 2024 2024 Citations: 4
Safety evaluation of Mikania glomerata and Mikania laevigata in healthy volunteers: A randomized, open label and multiple dose phase I clinical trial G Bertol, A de Fatima Cobre, ML Campos, R Pontarolo Journal of Ethnopharmacology, 117018 , 2023 2023 Citations: 6
Pharmacokinetics of isoniazid in Wistar rats exposed to ethanol TB Franchin, JA Oliveira, CD Candido, ES Martins, EC Padilha, ... Brazilian Journal of Pharmaceutical Sciences 58 , 2023 2023 Citations: 2
Pharmacokinetic Profile of Metformin and SGLT2 Inhibitors alone and in Combination: a Pharmacokinetic Study in Wistar Rats MM Fachi, BCL Dias, JA de Oliveria, RG Peccinini, R Pontarolo, ... Journal of Applied Bioanalysis , 2023 2023 Citations: 1
PD29 Systematic Review With Meta-analysis Of Pharmacokinetic Parameters Of Tyrosine Kinase Inhibitors Used In Chronic Myeloid Leukemia M Fachi, M de Campos, A Junkert, R Vilhena, B Böger, A Cobre, ... International Journal of Technology Assessment in Health Care 38 (S1), S100-S100 , 2022 2022
Plasma and erythocyte magnesium levels: from validation of the method to analysis in volunteers diagnosed to migraine MT Hoshino, MG Bochio, JS Bonache, L Ludwig, ML de Campos, ... Magnesium Research 35 (2), 51-61 , 2022 2022
Ceftriaxone and methicillin-susceptible staphylococcus aureus : a perspective from pharmacokinetics/pharmacodynamics studies JP Telles, RCP Leme, ML Campos, C Ito, L Bail, KS Nogueira, FF Tuon Expert Opinion on Drug Metabolism & Toxicology , 2021 2021 Citations: 9
In vitro metabolism of copalic and kaurenoic acids in rat and human liver microsomes M Mauro, RM Silva, ML Campos, A Bauermeister, NP Lopes, NV Moraes Química Nova 44, 700-708 , 2021 2021 Citations: 3
New Validated Method for Quantification of Glycated Hemoglobin by LC-QToF-MS: Is HRMS able to quantify clinical samples? LB Cerqueira, MM Fachi, WH Kawaguchi, FLD Pontes, ML Campos, ... Journal of the American Society for Mass Spectrometry , 2020 2020 Citations: 7
In vivo and in vitro anti-inflammatory and pro-osteogenic effects of citrus cystatin CsinCPI-2 NDP Leguizamón, EM Rodrigues, ML de Campos, AVB Nogueira, ... Cytokine 123, 154760 , 2019 2019 Citations: 41
Design, synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent MOP Rolim, AR de Almeida, MG da Rocha Pitta, MJB de Melo Rêgo, ... International immunopharmacology 76, 105856 , 2019 2019 Citations: 23
A new HPLC‐MS/MS method for the simultaneous quantification of SGLT2 inhibitors and metformin in plasma and its application to a pharmacokinetic study in healthy volunteers BCL Dias, MM Fachi, ML de Campos, FLD Degaut, RG Peccinini, ... Biomedical Chromatography, e4663 , 2019 2019 Citations: 36
Acid diterpenes from copaiba oleoresin (Copaifera langsdorffii): chemical and plasma stability and intestinal permeability using Caco-2 cells M Mauro, RA De Grandis, ML De Campos, A Bauermeister, RG Peccinini, ... Journal of Ethnopharmacology , 2019 2019 Citations: 16
New Pioglitazone Metabolites and Absence of Opened-Ring Metabolites in New N-Substituted Thiazolidinedione ML Campos, LB Cerqueira, BCU Silva, TB Franchin, MR Galdino-Pitta, ... Drug Metabolism and Disposition 46 (6), 879-887 , 2018 2018 Citations: 17
Plasma and peritoneal fluid concentrations of ceftriaxone after intravenous and intraperitoneal administration in horses JM Alonso, RG Peccinini, ML Campos, TY Nitta, TYM Akutagawa, ... The Veterinary Journal 234, 72-76 , 2018 2018 Citations: 8
Efficacy and Safety of Chagas Disease Drug Therapy and Treatment Perspectives WH Kawaguchi, LB Cerqueira, MM Fachi, ML Campos, IJM Reason, ... Chagas Disease-Basic Investigations and Challenges , 2018 2018 Citations: 18
Acid diterpenes from copaiba oleoresin (Copaifera langsdorffii): chemical and plasma stability and M Mauro, RA De Grandis, ML De Campos, A Bauermeister, RG Peccinini, ... 2018
Anti-Inflammatory Effect of Malva sylvestris, Sida cordifolia, and Pelargonium graveolens Is Related to Inhibition of Prostanoid Production CAF Martins, ML Campos, AC Irioda, DP Stremel, ACLB Trindade, ... Molecules 22 (11), 1883 , 2017 2017 Citations: 78
MOST CITED SCHOLAR PUBLICATIONS
Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite (s) VO Gutierres, ML Campos, CA Arcaro, RP Assis, HM Baldan-Cimatti, ... Evidence-Based Complementary and Alternative Medicine 2015 , 2015 2015 Citations: 118
Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy FC Carvalho, ML Campos, RG Peccinini, MPD Gremião European Journal of Pharmaceutics and Biopharmaceutics 84 (1), 219-227 , 2013 2013 Citations: 114
Anti-Inflammatory Effect of Malva sylvestris, Sida cordifolia, and Pelargonium graveolens Is Related to Inhibition of Prostanoid Production CAF Martins, ML Campos, AC Irioda, DP Stremel, ACLB Trindade, ... Molecules 22 (11), 1883 , 2017 2017 Citations: 78
Imprint desorption electrospray ionization mass spectrometry imaging for monitoring secondary metabolites production during antagonistic interaction of fungi A Tata, C Perez, ML Campos, MA Bayfield, MN Eberlin, DR Ifa Analytical chemistry 87 (24), 12298-12305 , 2015 2015 Citations: 69
Monitoring Toxic Ionic Liquids in Zebrafish ( Danio rerio ) with Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) CJ Perez, A Tata, ML de Campos, C Peng, DR Ifa Journal of The American Society for Mass Spectrometry 28 (6), 1136-1148 , 2017 2017 Citations: 63
In vivo and in vitro anti-inflammatory and pro-osteogenic effects of citrus cystatin CsinCPI-2 NDP Leguizamón, EM Rodrigues, ML de Campos, AVB Nogueira, ... Cytokine 123, 154760 , 2019 2019 Citations: 41
Evaluation of Antimalarial Activity and Toxicity of a New Primaquine Prodrug MG Davanço, ACC Aguiar, LA dos Santos, EC Padilha, ML Campos, ... PloS one 9 (8), e105217 , 2014 2014 Citations: 37
A new HPLC‐MS/MS method for the simultaneous quantification of SGLT2 inhibitors and metformin in plasma and its application to a pharmacokinetic study in healthy volunteers BCL Dias, MM Fachi, ML de Campos, FLD Degaut, RG Peccinini, ... Biomedical Chromatography, e4663 , 2019 2019 Citations: 36
Benznidazole extended-release tablets for improved treatment of Chagas disease: preclinical pharmacokinetic study MG Davanço, ML Campos, TA Rosa, EC Padilha, AH Alzate, LA Rolim, ... Antimicrobial agents and chemotherapy 60 (4), 2492-2498 , 2016 2016 Citations: 29
Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect JL Santos, V Moreira, ML Campos, RC Chelucci, KP Barbieri, ... International journal of molecular sciences 13 (11), 15305-15320 , 2012 2012 Citations: 25
Design, synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent MOP Rolim, AR de Almeida, MG da Rocha Pitta, MJB de Melo Rêgo, ... International immunopharmacology 76, 105856 , 2019 2019 Citations: 23
Biocompatible microemulsion modifies the pharmacokinetic profile and cardiotoxicity of doxorubicin JUCV AssumpçãO, ML Campos, MAF Nogueira Filho, KC Pestana, ... Journal of pharmaceutical sciences 102 (1), 289-296 , 2013 2013 Citations: 21
A systematic and critical review on bioanalytical method validation using the example of simultaneous quantitation of antidiabetic agents in blood MM Fachi, LP Leonart, LB Cerqueira, FLD Pontes, ML de Campos, ... Journal of Chromatography B 1055, 61-71 , 2017 2017 Citations: 20
Efficacy and Safety of Chagas Disease Drug Therapy and Treatment Perspectives WH Kawaguchi, LB Cerqueira, MM Fachi, ML Campos, IJM Reason, ... Chagas Disease-Basic Investigations and Challenges , 2018 2018 Citations: 18
Ceftriaxone pharmacokinetics by new simple and sensitive ultra-high-performance liquid chromatography method ML Campos, J de Moura Alonso, E dos Santos Martins, JA Oliveira, ... Diagnostic Microbiology and Infectious Disease 88 (1), 95-99 , 2017 2017 Citations: 18
New Pioglitazone Metabolites and Absence of Opened-Ring Metabolites in New N-Substituted Thiazolidinedione ML Campos, LB Cerqueira, BCU Silva, TB Franchin, MR Galdino-Pitta, ... Drug Metabolism and Disposition 46 (6), 879-887 , 2018 2018 Citations: 17
Acid diterpenes from copaiba oleoresin (Copaifera langsdorffii): chemical and plasma stability and intestinal permeability using Caco-2 cells M Mauro, RA De Grandis, ML De Campos, A Bauermeister, RG Peccinini, ... Journal of Ethnopharmacology , 2019 2019 Citations: 16
Rapid and sensitive ultra‐high‐pressure liquid chromatography method for quantification of antichagasic benznidazole in plasma: application in a preclinical pharmacokinetic study MG Davanço, ML Campos, RG Peccinini Biomedical Chromatography 29 (7), 1008-1015 , 2015 2015 Citations: 14
A Review of Pharmacokinetic Parameters of Metabolites and Prodrugs M Leandro de Campos, E Carvalho Padilha, R Goncalves Peccinini Drug Metabolism Letters 7 (2), 105-116 , 2013 2013 Citations: 14
Pharmacokinetic profile of a new diclofenac prodrug without gastroulcerogenic effect M Leandro de Campos, H Mariana Baldan-Cimatti, M Gomes Davanco, ... Drug metabolism letters 6 (4), 235-241 , 2012 2012 Citations: 12
