Immunoexpression of HIF-1α and VEGF in periodontal disease and healthy gingival tissues Roseane Carvalho Vasconcelos, Antônio de Lisboa Lopes Costa, Roseana de Almeida Freitas, Bruna Aguiar do Amaral Bezerra, Bruna Rafaela Martins dos Santos, et al. Brazilian Dental Journal, 2016 Hypoxia-inducible factor 1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) are proteins that stimulate the proliferation and migration of endothelial cells. These proteins have been described in many pathologic and inflammatory conditions, but their involvement in the development of periodontitis has not been thoroughly investigated. This study compared the immunohistochemical expression of these proteins, involved in angiogenesis and hypoxia, by imunnostained inflammatory and endothelial cells in periodontal disease and healthy gingival tissues. Gingival tissue samples were divided as follows: 30 samples with chronic periodontitis, 30 with chronic gingivitis, and 30 of healthy gingiva. Results were analyzed statistically by the Kruskal-Wallis, Mann-Whitney and Spearman correlation tests (p=0.01). Inflammatory and endothelial cells were found to express these proteins. Periodontitis showed median percentage of HIF-1α-positive cells of 39.6%, 22.0% in cases of gingivitis and 0.9% in the healthy gingiva group (p=0.001). For VEGF, median percentage of immunopositive cells was 68.7% for periodontitis, 66.1% in cases for gingivitis, and 19.2% for healthy gingival specimens (p<0.001). Significant correlation between VEGF and HIF-1α was also observed in healthy gingiva (p<0.001).The increased expression of HIF-1αα and VEGF in periodontitis, compared to gingivitis and healthy gingiva, suggests possible activation of the HIF-1α pathway in advanced periodontal disease. The correlation between HIF-1α and VEGF expression in healthy gingiva suggests a physiological function for these proteins in conditions of homeostasis. In periodontal disease, HIF-1 and VEGF expression may be regulated by other factors, in addition to hypoxia, such as bacterial endotoxins and inflammatory cytokines.
Prevalence of subgingival staphylococcus at periodontally healthy and diseased sites Bruna Rafaela Martins dos Santos, Clarissa Favero Demeda, Eutália Elizabeth Novaes Ferreira da Silva, Maria Helena Marques Fonseca de Britto, Kenio Costa Lima, et al. Brazilian Dental Journal, 2014 Staphylococci are considered members of the transient oral microbiota and are seldom isolated from the oral cavity. The aim of this study was to establish the prevalence of subgingival staphylococci in healthy and periodontal disease sites. Sterile endodontic paper points were used to isolate subgingival staphylococci in periodontally healthy and periodontally diseased sites in 30 adult subjects (n=540 sites). Staphylococcus spp were identified by an automated method and confirmed by conventional biochemical tests. All the samples were identified as coagulase-negative staphylococci. The results were analyzed using Mann-Whitney U, chi-square and Fisher's exact test at 5% significance level. A total of 86.7% of the subjects harbored these microorganisms in 11.7% of their periodontal sites. The most frequently isolated species was S. auricularis, which was isolated from 31.4% of the periodontal sites, followed by S. epidermidis, isolated from 21.4% of them. There was no statistically significant difference between the frequencies of these species isolated either from the healthy and the diseased sites (p>0.153). Although staphylococci are present in the subgingival environment and contribute to the pathogenic synergism involved in periodontal diseases, the results suggest that they do not participate directly in the pathogenesis of these diseases.
AVALIAÇÃO DO CONHECIMENTO E DO MANEJO CLÍNICO BUCAL DE ENDOCRINOLOGISTAS FRENTE A PACIENTES QUE ESTEJAM EM RASTREAMENTO OU EM TRATAMENTO PARA DIABETES MELLITUS. FM Silva Guedes, A Silveira Santos, I Rodrigues Suassuna, ... Arquivos de Ciências da Saúde da UNIPAR 27 (5) , 2023 2023
Evaluation of endocrinologists' knowledge and oral clinical management of patients being examined or treated for diabetes mellitus. FMS Guedes, AS Santos, IR Suassuna, RSC Soares, RCB Gomes, ... 2023
Condição periodontal associada aos determinantes sociais e à condição sistêmica de pacientes do serviço de periodontia da Universidade Estadual da Paraíba AS Santos, LNS Brito, MG Monteiro, RA de Farias, LP de Aguiar Cabral, ... Research, Society and Development 11 (10), e306111032698-e306111032698 , 2022 2022
Condição periodontal associada à prática de higiene bucal e ao hábito de fumar de pacientes do serviço de periodontia da Universidade Estadual da Paraíba AS Santos, LNS Brito, MG Monteiro, RA de Farias, LP de Aguiar Cabral, ... Research, Society and Development 11 (10), e307111032702-e307111032702 , 2022 2022 Citations: 1
Effect of the endocannabinoid system in memory updating and forgetting P Lunardi, LW de Souza, B Dos Santos, B Popik, L de Oliveira Alvares Neuroscience 444, 33-42 , 2020 2020 Citations: 26
Abordagem dos cirurgiões-dentistas da Estratégia Saúde da Família sobre o câncer bucal CJR de Freitas, MÂF Fernandes, BRM Santos, TMS de Souza Rosendo Revista da Faculdade de Odontologia-UPF 25 (2), 198-205 , 2020 2020 Citations: 3
Análise da condição periodontal e presença de patologias orais em pacientes com doença renal crônica KP Câmara, ND Cardoso, BRM dos Santos ARCHIVES OF HEALTH INVESTIGATION 7 , 2018 2018
Análise da condição periodontal e presença de patologias orais em pacientes com doença renal crônica BRM dos Santos 2018
Alterações da superfície do titânio tratado por plasma através da nitretação por cátodo oco e seu efeito na proliferação de células-tronco JC Sá, C Alves Junior, BRM Santos, EES Lucena Full dent. sci, 139-143 , 2017 2017
Immunoexpression of HIF-1α and VEGF in Periodontal Disease and Healthy Gingival Tissues A Freitas, BA do Amaral Bezerra, BR Martins, LPP dos Santos, ... Braz Dent J 27, 2 , 2016 2016
Immunoexpression of HIF-1α and VEGF in periodontal disease and healthy gingival tissues RC Vasconcelos, ALL Costa, RA Freitas, BAA Bezerra, BRM Santos, ... Brazilian dental journal 27 (2), 117-122 , 2016 2016 Citations: 82
Transmaxillary Access for Resection of Nasopharyngeal Juvenile Angiofibroma: A Case Report GDEO VIEIRA, LB DE SOUZA, RTA PINHEIRO, RDEA FREITAS, ... Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120 (2), e75 , 2015 2015
Peutz–Jeghers Syndrome: Case Report IADEA SENA, ELF DE LIMA, BRM DOS SANTOS, RTA PINHEIRO, ... Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120 (2), e62-e63 , 2015 2015
Peutz–Jeghers Syndrome: Case Report: PCC-195 IA DE ARAUJO SENA, ELF DE LIMA, BR DOS SANTOS, RTA PINHEIRO, ... Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120 (2), e62-e63 , 2015 2015
Cervicofacial Necrotizing Fasciitis: A Case Report LASP FERREIRA, HHA DE MORAIS, JCM BARBALHO, ... Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120 (2), e39 , 2015 2015
Pseudoankylosis Caused by Osteoma of the Coronoid Process: A Case Report SD BARRETO, BRM DOS SANTOS, HHA DE MORAIS, ... Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120 (2), e38 , 2015 2015
Surgical Resection of Mandible as Treatment for Central Giant Cell Lesion: Clinical Case Report IADEA SENA, IPC LIMA, RTA PINHEIRO, RDEA FREITAS, LB DE SOUZA, ... Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120 (2), e56 , 2015 2015
Immunohistochemical Analysis of Proteins Related to Th1, Th2 and Th17 Responses in Periodontal Disease BRM DOS SANTOS, VADEO MAIA, BADOA BEZERRA, MCDAC MIGUEL, ... Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120 (2), e95 , 2015 2015
Neurilemmoma of the oral cavity in pediatric patient PPA Santos, BRM Santos, VS Freitas, RA Freitas, LB Souza RGO. Revista Gaúcha de Odontologia (Online) 60 (3), 281-383 , 2012 2012 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Immunoexpression of HIF-1α and VEGF in periodontal disease and healthy gingival tissues RC Vasconcelos, ALL Costa, RA Freitas, BAA Bezerra, BRM Santos, ... Brazilian dental journal 27 (2), 117-122 , 2016 2016.0 Citations: 82
Immunohistochemical expression of E-cadherin and β-catenin in ameloblastomas and tooth germs KMA Pereira, BA do Amaral, BRM dos Santos, HC Galvão, ... Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and … , 2010 2010.0 Citations: 42
Effect of the endocannabinoid system in memory updating and forgetting P Lunardi, LW de Souza, B Dos Santos, B Popik, L de Oliveira Alvares Neuroscience 444, 33-42 , 2020 2020.0 Citations: 26
An epidemiological study of immune-mediated skin diseases affecting the oral cavity CHP Carvalho, BRM Santos, CC Vieira, ENA Lima, PPA Santos, ... Anais brasileiros de dermatologia 86, 905-909 , 2011 2011.0 Citations: 25
A importância da bioética na odontologia do século XXI RCD Galvão, LMM Silva, FR Matos, BRM Santos, HC Galvão, RA Freitas Odontologia Clínico-Científica (Online) 9 (1), 13-18 , 2010 2010.0 Citations: 25
Immunohistochemical expression of matrix metalloproteinases 1, 2, 7, 9, and 26 in the calcifying cystic odontogenic tumor BF Ribeiro, CRF de Araújo, BRM dos Santos, R de Almeida Freitas Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and … , 2011 2011.0 Citations: 19
Estudo epidemiológico das doenças dermatológicas imunologicamente mediadas na cavidade oral CHP Carvalho, BRM Santos, CC Vieira, ENA Lima, PPA Santos, ... Anais Brasileiros de Dermatologia 86, 905-909 , 2011 2011.0 Citations: 11
Abordagem dos cirurgiões-dentistas da Estratégia Saúde da Família sobre o câncer bucal CJR de Freitas, MÂF Fernandes, BRM Santos, TMS de Souza Rosendo Revista da Faculdade de Odontologia-UPF 25 (2), 198-205 , 2020 2020.0 Citations: 3
Prótese Parcial Removível Rotacional: conhecimento e aplicabilidade pelos profissionais do Estado do Rio Grande do Norte BA Amaral, BRM Santos, CFR Bezerra, AFP Carreiro, AUD Batista, ... Odontol. clín.-cient, 155-161 , 2007 2007.0 Citations: 3
Neurilemmoma of the oral cavity in pediatric patient PPA Santos, BRM Santos, VS Freitas, RA Freitas, LB Souza RGO. Revista Gaúcha de Odontologia (Online) 60 (3), 281-383 , 2012 2012.0 Citations: 2
Condição periodontal associada à prática de higiene bucal e ao hábito de fumar de pacientes do serviço de periodontia da Universidade Estadual da Paraíba AS Santos, LNS Brito, MG Monteiro, RA de Farias, LP de Aguiar Cabral, ... Research, Society and Development 11 (10), e307111032702-e307111032702 , 2022 2022.0 Citations: 1
Interrelação periodontia e prótese AP Maia, BA Amaral, BRM Santos, MNM Nogueira, EG Seabra Multidisciplinaridade na saúde bucal, 17-25 , 2009 2009.0 Citations: 1
Prevalência e susceptibilidade antimicrobiana de Staphylococcus spp. em quadros de saúde e doença periodontal. 2007 BRM SANTOS Dissertação de Mestrado. Universidade Federal do Rio Grande do Norte , 0 Citations: 1
AVALIAÇÃO DO CONHECIMENTO E DO MANEJO CLÍNICO BUCAL DE ENDOCRINOLOGISTAS FRENTE A PACIENTES QUE ESTEJAM EM RASTREAMENTO OU EM TRATAMENTO PARA DIABETES MELLITUS. FM Silva Guedes, A Silveira Santos, I Rodrigues Suassuna, ... Arquivos de Ciências da Saúde da UNIPAR 27 (5) , 2023 2023.0
Evaluation of endocrinologists' knowledge and oral clinical management of patients being examined or treated for diabetes mellitus. FMS Guedes, AS Santos, IR Suassuna, RSC Soares, RCB Gomes, ... 2023.0
Condição periodontal associada aos determinantes sociais e à condição sistêmica de pacientes do serviço de periodontia da Universidade Estadual da Paraíba AS Santos, LNS Brito, MG Monteiro, RA de Farias, LP de Aguiar Cabral, ... Research, Society and Development 11 (10), e306111032698-e306111032698 , 2022 2022.0
Análise da condição periodontal e presença de patologias orais em pacientes com doença renal crônica KP Câmara, ND Cardoso, BRM dos Santos ARCHIVES OF HEALTH INVESTIGATION 7 , 2018 2018.0
Análise da condição periodontal e presença de patologias orais em pacientes com doença renal crônica BRM dos Santos 2018.0
Alterações da superfície do titânio tratado por plasma através da nitretação por cátodo oco e seu efeito na proliferação de células-tronco JC Sá, C Alves Junior, BRM Santos, EES Lucena Full dent. sci, 139-143 , 2017 2017.0
