BRAHMAIAH BONTHAGARALA

@brahmaiah.b@svcp.edu.in

Assistant Professor, Department of Pharmaceutics, Shri Vishnu College of Pharmacy, Bhimavaram
Shri Vishnu College of Pharmacy

BRAHMAIAH BONTHAGARALA


                     Download Compact PDF  
https://researchid.co/brahmaiah

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Pharmaceutical Science
9

Scopus Publications

Scopus Publications

  • Eco-friendly fabrication and characterization of polyherbal silver nanoparticle-loaded shampoo with enhanced antibacterial efficacy for the topical management of scalp and hair folliculitis
    Sunil T. Galatage, Arehalli S. Manjappa, Somnath D. Bhinge, Rama Rao Vadapalli, Nagineni Sudarshan Rao, Brahmaiah Bonthagarala, Arige Sirisha, Malleswara Rao Peram, Machindra R. Holam, Utkarsh V. Nagvekar, Unnam Sambamoorthy, Priyanka Powar
    Next Nanotechnology, 2026
    Folliculitis is a common dermatological disorder characterized by inflammation and bacterial infection of hair follicles, most frequently caused by Staphylococcus aureus . The present study aimed to develop a polyherbal silver nanoparticle (PH-AgNPs)–loaded shampoo using a green synthesis approach to exploit phytochemical synergy for enhanced antibacterial efficacy in the management of scalp folliculitis. Silver nanoparticles were synthesized by reducing silver nitrate (AgNO₃) with an aqueous polyherbal extract containing Acacia concinna , Camellia oleifera , Emblica officinalis , and Sapindus mukorossi , which simultaneously acted as reducing and stabilizing agents. The synthesized PH-AgNPs were characterized using UV–visible spectroscopy, dynamic light scattering (DLS), zeta potential analysis, and energy-dispersive X-ray spectroscopy (EDX). The nanoparticles exhibited a mean particle size of 87 ± 2 nm, a polydispersity index of 0.218 ± 0.07, and a zeta potential of −33.2 ± 2.1 mV, indicating good colloidal stability. Antibacterial evaluation demonstrated potent activity against S. aureus , with a minimum inhibitory concentration (MIC) of 0.8 ± 0.06 µg/mL and a minimum bactericidal concentration (MBC) of 3.12 ± 0.5 µg/mL. Furthermore, PH-AgNPs significantly inhibited bacterial adhesion and biofilm formation in a dose-dependent manner, achieving complete biofilm inhibition at MBC within 48 h. Incorporation of PH-AgNPs into a shampoo base provides a green, polyherbal-synergistic topical nanotherapeutic system with promising potential for the treatment of bacterial folliculitis, warranting further in vivo and clinical investigations to confirm therapeutic safety and efficacy. • Polyherbal silver nanoparticles (PH-AgNPs) were synthesized using a green approach from Acacia concinna , Camellia oleifera , Emblica officinalis , and Sapindus mukorossi . • The synthesized PH-AgNPs showed nanoscale size (87 ± 2 nm) and high stability (zeta potential −33.2 ± 2.1 mV). • PH-AgNPs exhibited strong antibacterial activity against Staphylococcus aureus with MIC = 0.8 μg/mL and MBC = 3.12 μg/mL. • The PH-AgNPs effectively inhibited bacterial adhesion and biofilm formation, demonstrating potential for treating scalp folliculitis.
  • Phytochemical Screening and Microbicidal Activity of Siegesbeckia orientalis Against Human Bacterial Pathogens
    Surya Prabha Matangi, Ramu Samineni, Shaik Khadir Yazdan, Subramanyam Sibbala, A. Suneetha Devi, Sampath A. Gouru, Brahmaiah Bonthagarala, M. Guru Prasad, V. Sridevi
    Journal of Natural Remedies, 2026
    Background: Sigesbeckia orientalis, commonly known as the “Chinese herb” has been utilized in traditional medicine for its various therapeutic properties. This plant is part of the Asteraceae family and is known for its anti-inflammatory, analgesic, and antimicrobial effects. The increasing prevalence of antibiotic-resistant pathogens has prompted researchers to explore alternative sources of antimicrobial agents, particularly from natural products. Aim: This study investigated the ability of Sigesbeckia orientalis to inhibit common human pathogens, including Proteus vulgaris, Staphylococcus aureus, Klebsiella sp., Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Trichophyton rubrum, and Epidermophyton floccosum. Method: Fifty grams of crushed material were treated with 300 ml each of chloroform, hexane, methanol, and ethanol for 24 hours at 23±2°C. The extracts were filtered through Whatman filter paper into a clean beaker. A second extraction was performed with the same solvents for another 24 hours, followed by filtration. The combined extracts were evaporated using a rotary flash evaporator and stored in sealed containers at 4°C until further use. Results: The ethanol extract showed significant antibacterial activity, particularly against Pseudomonas aeruginosa (15 mm) and Staphylococcus aureus (13 mm). In contrast, the chloroform extract was less effective, with minimal inhibition against several bacteria. Minimum inhibitory concentrations (MICs) were 0.75 mg/ml for S. aureus and 1.0 mg/ml for P. aeruginosa, while other bacterial isolates exceeded 2.0 mg/ml. MIC values for Trichophyton rubrum and Epidermophyton floccosum from the ethanol extract were higher than the standard antifungal agent, ketoconazole. Conclusion: These findings support the antimicrobial potential of phytoconstituents in traditional medicinal plants for developing new treatments for infections. Major Findings: The antimicrobial activity observed in plant extracts may be attributed to the presence of one or more phytoconstituent active compounds, which could be functioning synergistically. According to the current study’s findings, S. orientalis leaf preparations in ethanol contain a variety of pharmacologically potent substances.
  • Improving Solubility and Dissolution Characteristics of Dapoxetine Hydrochloride through the Liquisolid Compact Method
    , Nagineni Sudarshan Rao, Rama Rao Vadapalli, , Brahmaiah Bonthagarala, , Jalluri Charishma Vasavi, , Mallabathula Meghana, and
    International Journal of Drug Delivery Technology, 2025
    This study aimed to enhance the solubility and dissolution properties of Dapoxetine hydrochloride (DXH) tablets by using of novel method i.e., liquisolid compact technology (LCT). A total of 9 formulations of DXH tablets were prepared by using carrier materials like microcrystalline cellulose and coating materials like lactose, silica, and starch. In out of nine formulations Super disintegrants like cross povidone (CP) in F1–F4 and Cross Carmellose Sodium in F5–F9 added. All formulations were evaluated for both pre compressional and post compressional evaluation parameters. Based on the evaluation parameters, the F6 formulation exhibited superior dissolution characteristics compared to others, indicating enhanced solubility rates. In vitro dissolution studies showed significantly improved release rates for DXH tablets.X-ray diffraction (XRD) analysis revealed a reduction in crystallinity, further supporting enhanced dissolution. Scanning electron microscopy (SEM) confirmed uniform dispersion of drug particles in the optimized formulation, leading to improved drug release. The absence of notable interactions between the drug and excipients was confirmed via FTIR analysis, ensuring formulation stability. In conclusion, LCT effectively enhanced the dissolution rate of DXH, demonstrating its potential as a promising approach for improving poorly water-soluble drugs.
  • IN VIVO AND IN SILICO ANTI-ATHEROSCLEROTIC ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF OCIMUM BASILICUM AND ANNONA RETICULATE
    , Premi Gelam, Rama R Vadapalli, , Sathish K. Konidala, , Ramayyappa Muddala, , Brahmaiah Bonthagarala, , Geethika V. R. Samineni, , Mohammed Shakir, , Mounica R. Meka, , Eswari Singampalli, , Raveendra B. Gudimetla, and
    Indian Drugs, 2025
    Annona reticulata and Ocimum basilicum plants are known for their medicinal qualities and exhibit promise in managing atherosclerosis by regulating lipid levels. The study assessed the potential of selected extracts in managing atherosclerosis in hyperlipidemia induced rats with a high-fat diet. Parameters such as body weight, organ weight, blood glucose and lipids levels were measured. Histopathology of the aorta was conducted. In silico docking study was conducted to predict the antiatherosclerosis activity against Liver X receptor and PPAR-γ proteins. The animal group treated with a mixed extract (1:1 ratio) (200 mg kg-1 body weight) of selected plants exhibited significantly reduced body weight and improved lipid profiles, compared to the control group. Histopathological analysis showed no significant changes in aortic diameter in the treated group compared to controls. In in silico analysis, the potential compounds with prominent interactions with target were proteins were predicted. These findings suggest that the mixed extract may possess atherosclerosis-controlling properties.
  • Formulation Optimization and Evaluation of Herbal Films Containing Ethanol Leaves Extract of Cassia auriculata to Treat Chronic Constipation Disorder
    Brahmaiah Bonthagarala, Seetha Devi Alla, Sudarshan Rao Nagineni, Rama Rao Vadapalli, Sri Rekha Malakapurapu
    International Journal of Drug Delivery Technology, 2024
    An intriguing trend in recent years has been the designing of oral films containing extracts from medicinal plants. Therefore, efforts were made in the current work to create fast-dissolving herbal films using Cassia auriculata ethanol leaf extract in order to create a dosage form that would be more convenient to administer and treat chronic constipation disorders in the elderly. Varying ratios of hydroxy propyl methyl cellulose as polymer, propylene glycol as film softener, and a solvent-casting approach were utilized to create the quickly dissolving herbal films of C. auriculata leaf extract. A number of quality control measures, including weight fluctuation, thickness variation, surface pH, percentage moisture uptake, percentage moisture loss, disintegration time and folding endurance, were assessed. According to the findings, every film had a decent appearance, a smooth texture, was free of particle matter, and had excellent folding endurance. According to a content uniformity analysis, the drug is dispersed evenly across the entire film, and each one dissolves in less than 95 seconds. In-vitro dissolving studies using Paddle type apparatus in pH 6.8 phosphate buffer pH 6.8, which is simulated saliva, were performed for each film composition. Out of all nine formulations, formulation F5, which is an herbal film with 10% propylene glycol and 40% HPMC, exhibited complete drug release (99.6%) in 30 minutes and had a strong folding endurance value. The release of medication from films was found to follow a first-order kinetics. Overall, studies indicate that the most feasible dose form that can be used in medical settings for the treatment of chronic constipation disorder is fast-dissolving herbal films containing C. auriculata leaves extract. This is especially true for patients who have difficulty swallowing.
  • WEARABLE MEDICAL DEVICES: STANDARDS, APPROVAL PROCESS AND REGULATORY ISSUES
    Pharma Times, 2024
  • Quality-by-Design based development and characterization of pioglitazone loaded liquisolid compact tablets with improved biopharmaceutical attributes
    Brahmaiah Bonthagarala, Varun Dasari, Vijay Kotra, Suryakanta Swain, Sarwar Beg
    Journal of Drug Delivery Science and Technology, 2019
  • Solubility enhancement effect at absorption site on bioavailability of ritonavir using liquisolid technique
    Brahmaiah Bonthagarala, Varun Dasari, Vijay Kotra
    Therapeutic Delivery, 2019
    Aim: The present study revolved around determining the effect of increase in the solubility of these drugs at the absorption site using ritonavir as a drug model. Materials & methods: Ritonavir per-oral tablets were prepared using versatile and nonionic surfactants having high solubilization rate, which were further marked with high rate of dissolution. The high rate of dissolution formula applied to the solid state characterization by means of transition electron microscopy, differential scanning calorimetry, scanning electron microscopy, X-ray diffraction and infrared spectroscopy. Results & conclusion: The drug bioavailability was seen to increase expressively by administration of liquisolid tablets as compared with conventional tablets.
  • Formulation and evaluation of orodispersible atenolol maleate tablets: A comparative study on natural super disintegrents and synthetic super disintegrents
    Brahmaiah Bonthagarala, Prasanth Pasumarthi, Katta Vamsi Kiran, Sathram Nataraja, Sudarshan Donthiboina
    International Journal of Research in Ayurveda and Pharmacy, 2014
    O ral Disintegrating T ablets (ODT s ) may also be used to deliver drugs to the oral cavity, for local action or, in some cases, absorption across the oral mucosa, thereby avoiding first - pass hepatic metabolism and po tentially increasing the rate and extent of uptake, and reducing undesirable metabolites. The o bjectives of the research work wa s to formulate oral disintegrating tablets of Atenolol maleate by using different super disintegrates (Natural, Synthetic) in di fferent ratio by direct compression technique and tablets were evaluated for pre compression and post compression parameters such as angle of repose, bulk density, tapped density, compressibility index, drug content and in - vitro drug release study, hardnes s, friability, wett ing time and in vitro dispersion time. Among the all formulations , the promising formula (CCS3, IH2) have showed fast disintegration and displayed in vitro d ispersion time of 11 s and 10.5 s. The dissolution rates of the optimized formul ations (CCS3, IH2) were found to be good. Among the promising ODT formulation CCS3, IH2 the formula IH2 was found to be superior when compared to formulation CCS3 since formulation IH2 us ed natural disintegrant (i.e . 6 %w/w Isphagula husk) at a lower conce ntration than the formulation CCS3 (8 % w/w Cross Carmellose Sodium) hence it wa s found to be more cost effective. The FTIR studies also showed that there was no interaction between drug and polymer. Formulation CCS3, IH2 were subjected to stability studie s as per ICH guidelines at temperatures and humidity of 25 ± 5oC/60 ± 5 % RH; and 40 ± 5oC/75 ± 5 % RH. Tablets didn’t reveal any appreciable changes with respect t o hardness, disintegration time , drug content and dissolution profile.