SUNILKUMAR BHIKCHAND BOTHARA

@gcopr.ac.in

Professor and Principal (Incharge) Government College of Pharmacy, Ratnagiri
Government College of Pharmacy, Ratnagiri

SUNILKUMAR BHIKCHAND BOTHARA


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https://researchid.co/botharasb1

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Toxicology and Pharmaceutics, Pharmacy
18

Scopus Publications

895

Scholar Citations

18

Scholar h-index

24

Scholar i10-index

Scopus Publications

  • In vivo, ex vivo, and in vitro mucoadhesive strength assessment of potential pharmaceutical bio-resource polymer from diospyros melonoxylon Roxb seeds
    Sudarshan Singh, Tanvi R Dodiya, Rajesh Dodiya, Sangeeta Singh, Sunil B Bothara
    International Journal of Pharmaceutical Sciences and Nanotechnology, 2021
    In this study, an oral bio-based mucoadhesive polymer was developed from Diospyros melonoxylon Roxb (Ebenaceae) seed mucilage and evaluated for mucoadhesive strength. The mucilage showed shear stress results (0.140 ± 0.0007N), with comparable adhesiveness to HPMC E5 (0.098 ± 0.0008N). Force of adhesion required to detach the seed mucilage and HPMC E5 tablets from the mucin of intestinal tissue were 0.0509 ± 0.0007 (N) and 0.0049 ± 0.0006 (N). Seed mucilage revealed significant higher detachment time, erosion time, in vitro wash off time and ex vivo residence compared to HPMC E5 and lactose tablets (p<0.01). In vivo test indicated that seed mucilage tablets possessed good mucoadhesive strength compared to HPMC E5 and resisted disintegration for ≤ 8 h. The swelling index and wetting time showed comparable results between the mucilage and synthetic polymer tablets. Mucilage demonstrated high moisture absorption, percentage hydration, and matrix erosion of 20.0 ± 0.037, 53.66 ± 0.127, and 20.00 ± 0.077 compared to HPMC E5 10.0 ± 0.079, 36.00 ± 0.089, and 1.26 ± 0.085. The mucoadhesive properties of seeds mucilage were comparable to guar gum and HPMC E5. Thus, seed mucilage of D. melonoxylon can be exploited for usage as pharmaceutical excipient in oral bioadhesive drug delivery systems.
  • Bio-based Polymer Isolated from Seeds of Buchanania lanzan Spreng with Potential Use as Pharmaceutical Mucoadhesive Excipient
    Sudarshan Singh, Tanvi R Dodiya, Sangeeta Singh, Rajesh Dodiya, Sunil B Bothara
    International Journal of Pharmaceutical Sciences and Nanotechnology, 2020
    This study was aimed to develop an oral bio-based mucoadhesive polymer from seeds mucilage of Buchanania lanzan spreng, belongs to family anacardiaceae. Isolated mucilage was evaluated for mucoadhesive strength and compared with existing polymer. The mucilage showed shear stress results (0.099 ± 0.0001N), with comparable adhesiveness to methocel E5 (0.098 ± 0.0008N). Force of adhesion required to detach the seed mucilage and methocel E5 tablets from the mucin of intestinal tissue were 0.0276 ± 0.0019 (N) and 0.0049 ± 0.0006 (N), respectively. Seed mucilage revealed significant (P<0.01) higher detachment time, erosion time, in-vitro wash-off time and ex-vivo residence compared to methocel E5 and lactose tablets. In vivo test indicated that seed mucilage tablets possessed good mucoadhesive strength compared to methocel E5 and resisted disintegration for ≤ 8 h. The swelling index and wetting time showed comparable results between the mucilage and synthetic polymer tablets. Mucilage demonstrated high moisture absorption, percentage hydration, and matrix erosion of 18.57 ± 0.036, 50.00 ± 0.051, and 8.30 ± 0.155 compared to methocel E5 10.0 ± 0.079, 36.00 ± 0.089, and 1.26 ± 0.085, respectively. Mucoadhesive properties of seeds mucilage were comparable to guar gum and methocel E5, thus seed mucilage of B. lanzan can be potentially exploited for usage as a bioadhesive pharmaceutical excipient.
  • Physico-chemical and structural characterization of mucilage isolated from seeds of Diospyros melonoxylon Roxb.
    Sudarshan Singh, Sunil B. Bothara
    Brazilian Journal of Pharmaceutical Sciences, 2014
    Mucilage was isolated from the seeds of Diospyros melonoxylonRoxb., a plant growing naturally in the forests of India. Various physico-chemical methods like particle analysis, scanning electron microscopy, differential scanning calorimetry, differential thermal analysis, thermogravimetry analysis, molecular weight by gel permeation chromatography, rheometry, elemental analysis, x-ray diffraction spectrometry, zeta potential, fourier transform infrared spectroscopy, 1D(1H and 13C) (NMR) have been employed to characterize this gum in the present study. Particle analyses suggest that mucilage had particle size in nanometer. SEM analysis suggested that the mucilage had irregular particle size. The glass transition temperature of the gum observed was 78 °C and 74 °C by DSC and DTA respectively. The Thermogravimetry analysis suggested that mucilage had good thermal stability with two stage decomposition. The molecular weight of mucilage was determined to be 8760, by gel permeation chromatography, while the viscosity of mucilage was observed to be 219.1 cP. The XRD pattern of the mucilage indicated a complete amorphous nature. Elemental analysis of the gum revealed specific contents of carbon, hydrogen, nitrogen and sulfur. The major functional groups identified from FT-IR spectrum include 3441 cm-1 (-OH), 1632 cm-1 (-COO-), 1414 cm-1 (-COO-) and 1219 cm-1 (-CH3CO). Analysis of mucilage by paper chromatography and 1D NMR indicated the presence of sugars.
  • Investigation of antihypertensive activity of leaves of Barleria Prionitis in doca salt induced hypertensive rats
    International Journal of Pharmaceutical Sciences Review and Research, 2013
  • Evaluation of anxiolytic activity of methanolic and aqueous root extracts of cocculus hirsutus
    International Journal of Pharmacy and Pharmaceutical Sciences, 2012
  • Thermal studies on natural polysaccharide
    Sunil B Bothara, Sudarshan Singh
    Asian Pacific Journal of Tropical Biomedicine, 2012
    To characterize thermal property of natural gums obtained from the seeds of Diospyros melonoxylon (D. melonoxylon) Roxb, Buchanania lanzan (B. lanzan) spreng and Manilkara zapota (M. zapota) (Linn.) P. Royen syn. Natural gums were thermally characterized using differential scanning calorimetry (DSC), differential thermal analysis (DTA) and thermo-gravimetric analysis (TGA) under nitrogen atmosphere. Major thermal transitions as well as activation energies of the major decomposition stages were determined. Elemental analysis was performed in order to determine the composition of carbon, hydrogen, nitrogen and sulfur. DSC traces indicated a major intense exothermic transition (around 200 °C) followed by weaker exotherm(s). Thermogravimetric analysis showed two phase of weight loss. The first phase has minor weight loss in samples is attributed to the loss of adsorbed and structural water of biopolymers or due to desorption of moisture as hydrogen bound water to the saccharide structure. The second weight loss event may be attributed to the polysaccharide decomposition. The initial decomposition temperature (IDT) was calculated from thermograms obtained of TGA, seed Polysaccharide of D. melonoxylon (IDT 221.21 °C), B. lanzan (IPDT 170.4 °C) and M. zapota (IPDT 178.6 °C) were obtained. According to the integral procedural decomposition temperature (IPDT) values calculated based on the TGA thermograms; D. melonoxylon (IPDT 563.3 °C), B. lanzan (IPDT 598.1 °C) and M. zapota (IPDT 600.6 °C) were obtained respectively. The elemental analysis study shows that the isolated natural Polysaccharides consist of certain percentage of carbon, nitrogen, sulphur and hydrogen in all the gums. The results of the present investigation reveal that the natural gums are thermally stable and these gums can be used as release modifiers in various dosage forms.
  • Pharmacognostical studies of seeds on some plants belonging Chhattisgarh
    Sunil B. Bothara, Sudarshan Singh
    Pharmacognosy Journal, 2012
    Abstract Diospyros melonoxylon Roxb . belonging to family Ebenaceae, commonly known as Tendu in Hindi is a small tree with rather slender stem and smooth grey bark. Buchanania lanzan spreng. commonly known as Char in Hindi is a tree of 12-15 mt high, with straight trunk, belonging to family Anacardiaceae. Manilkara zapota (Linn.) P. Royen syn., belonging to family sapotaceae commonly known as Chiku in Hindi is a large, evergreen, forest tree more than 30 mt in height. These three plants are easily available in the forests of Chhattisgarh used in various diseases traditionaly. The pharmacognostical studies of these plants were done by evaluating its microscopical studies, phytochemical screening, flourescence analysis of extracts of the seeds with different reagents and presence of Elemental analysis such as CHNS and heavy metals. The microscopical studies revealed the specific characters in all three seeds, it has obsereved and identified. Phytochemical screening revealed the presence of carbohydrates, proteins, fat and oils, present in extracts of all three seeds. Flourescence analysis of Extarcts of seeds shows diffrent colours with different reagents. The above pharmacognostical and preliminary phytochemical studies will be beneficial for proper identification and authentification of seeds of D. melonoxylon Roxb ., B. lanzan spreng, M. zapota (Linn.) P. Royen syn.
  • Preliminary pharmaceutical characterization of some flowers as natural indicator
    Pharma Research, 2011
  • Antiarthritic activity of root extracts of Cocculus hirsutus
    International Journal of Pharmacy and Pharmaceutical Sciences, 2011
  • In-vitro cytotoxicity evaluation of aqueous fruit and leaf extracts of Grewia asiatica using MTT assay
    Der Pharma Chemica, 2011
  • Ethnopharmacological properties of cocculus hirsutus (L.) diels- a review
    International Journal of Pharmaceutical Sciences Review and Research, 2011
  • Pharmaceutical characterization of Prosopis Juliflora (SW) seed mucilage - excipient
    Pharma Research, 2011
  • Acid-base indicator properties of dyes from local flowers: Cassia aungostifolia Linn., Thevetia peruviana (Pers.) K. Schum and Thevetia thvetiodes (Kunth) K. Schum
    Sudarshan Singh, S.B. Bothara, Sangeeta Singh
    Pharmacognosy Journal, 2011
  • Evaluation of aqueous extract of Ocimum sanctum in experimentally induced parkinsonism
    Journal of Chemical and Pharmaceutical Research, 2011
  • Preliminary pharmaceutical characterization of some flowers as natural indicator: Acid-base titration
    Sudarshan Singh, S.B. Bothara, Sangeeta Singh, Roshan Patel, Reena Ughreja
    Pharmacognosy Journal, 2011
  • Effect of chronic administration of green tea extract on chemically induced electrocardiographic and biochemical changes in rat heart
    LeenaJ Patil, SunilB Bothara, R Balaraman
    International Journal of Green Pharmacy, 2010
  • Anticonvulsant activity of Abutilon indicum leaf
    International Journal of Pharmacy and Pharmaceutical Sciences, 2010
  • Effect of atorvastatin treatment on isoproterenol-induced myocardial infarction in rats
    Chitrang J. Trivedi, R. Balaraman, Jayesh B. Majithiya, Sunil B. Bothara
    Pharmacology, 2006

RECENT SCHOLAR PUBLICATIONS

  • Exploring The Impact of Bite-to-Needle Time on Snakebite Complications: Insights from a Study at Tertiary Care Hospital
    SP Bhattacharya MA, Bothara SB, Aher A, Chavan A, Bhagore S
    International Journal of Medical and Pharmaceutical Research 6 (4), 680‐699 , 2025
    2025
  • FEATURES AND FACTS OF MUCOADHESIVE BUCCAL TABLET: AN OVERVIEW
    Shaikh SM, Bothara SB, Kachare DM
    WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 12 (5) , 2023
    2023
  • NANOSUSPENSION: AN OVERVIEW
    Kachare DM, Shaikh SM, Bothara SB
    WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 12 (5) , 2023
    2023
  • A Nano Drug Carrier System: NIOSOMES
    Pardeshi JC, Jogdade NN, Bothara SB
    International Journal for Research Trends and Innovation 7 (9), 523-534 , 2022
    2022
  • In vivo, ex vivo and in vitro Mucoadhesive Strength Assessment of Potential Pharmaceutical Bio-resource Polymer from Diospyros melonoxylon Roxb seeds
    S Singh, TR Dodiya, R Dodiya, S Singh, SB Bothara
    International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN … , 2021
    2021
    Citations: 4
  • NANOCOCHLEATE – AN IMPORTANT DRUG DELIVERY SYSTEM OFFERING UNIQUE FEATURES
    MVL Pawar SF, Bothara SB, Mahaparale PR
    World Journal of Pharmaceutical Research 9 (9) , 2020
    2020
    Citations: 7
  • Methods of Pelletization Using Extrusion – Spheronization: A Review
    LPS Barkate AR, Bothara SB, Tambade SB, Mahaparale PR
    International journal of Pharmacy and Pharm res 18 (1) , 2020
    2020
    Citations: 5
  • Nanosuspension: A Novel Approach for Poorly Water Soluble Drugs
    LPS Tambade SB, Bothara SB, Barkate AR3, Mahaparale PR
    International journal of Pharmacy and Pharm res 18 (4) , 2020
    2020
  • Bio-based polymer isolated from seeds of Buchanania lanzan spreng with potential use as pharmaceutical mucoadhesive excipient
    TR Dodiya, S Singh, R Dodiya, SB Bothara
    International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN … , 2020
    2020
    Citations: 8
  • Antioxidant and antimutagenic potential of Ipomoea reniformis Roxb. leaf, cyclophosphamide induced bone marrow micronucleuses test in mice
    SK Vaidya, DK Golwala, NB Gohil, SB Bothara
    Aegaeum J 8 (2), 262-71 , 2020
    2020
    Citations: 1
  • Evaluation of Nootropic Activty of Gmelina arborea in Experimental Animal Models
    DN Madiya, B SB
    Inventi Impact: Ethnopharmacology 2018 (3), 1-4 , 2018
    2018
  • EVALUATION OF NOOTROPIC ACTIVTY OF CAYRATIA TRIFOLIA IN EXPERIMENTAL ANIMAL MODELS
    MDNDSB Bothara
    WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 7 (6), 1558-1568 , 2018
    2018
  • FAST DISSOLVING TABLET: A REVIEW
    SBBPRM Pritam T. Kelgire
    European Journal of Pharmaceutical and Medical Research 4 (10), 213-219 , 2017
    2017
    Citations: 2
  • Evaluation of Antioxidant and Antidiabetic Effect of Ipomoea reniformis Chois in Alloxan Induced Diabetes in Rats
    VSK Bothara, SB
    International Journal of Pharmacy and Pharmaceutical Reserach 6 (3), 251-279 , 2016
    2016
    Citations: 5
  • Solubility enhancement of nevirapine by cocrystallisation technique
    YK Nalte, VA Arsul, SG Shep, SB Bothara
    J. Pharm. Res 9 (8), 556-561 , 2015
    2015
    Citations: 19
  • Solubility enhancement of nevirapine by hydrotropic solubilization
    VA Arsul, RN Gopale, SG Shep, SB Bothara
    Indo American Journal of Pharmaceutical Sciences 2 (8), 1240-1247 , 2015
    2015
    Citations: 5
  • Formulation and Evaluation of Self-microemulsifying drug delivery system of Curcumin for enhanced solubility and dissolution
    AR Sahu, SB Bothara
    Asian Journal of Pharmaceutical Education and Research 4 (1), 48-59 , 2015
    2015
    Citations: 3
  • EVALUATION OF ANTICANCER POTENTIAL OF IPOMOEA RENIFORMIS CHOIS (CONVOLVULACEAE) LEAVES AGAINST EHRLICH ASCITES INDUCED CANCER IN MICE
    VSK Bothara SB
    Indo American journal of Pharm Reserach 5 (12) , 2015
    2015
  • Formulation and Ex-vivo Evaluation of Transdermal Patches of Glipizide using the Penetration Enhancer Buchanania-Lanzan (Spreng) Seed Oil
    S Singh, SB Bothara, PD Roshan, MK Naveen
    International Journal of Pharmaceutical Science and nano technology 8 (1 … , 2015
    2015
    Citations: 5
  • In vivo mucoadhesive strength appraisal of gum Manilkara zapota
    S Sudarshan, B Sunil B
    Brazilian Journal of Pharmaceutical Sciences 51, 689-698 , 2015
    2015
    Citations: 14

MOST CITED SCHOLAR PUBLICATIONS

  • Thermal studies on natural polysaccharide
    SB Bothara, S Singh
    Asian Pacific Journal of Tropical Biomedicine 2 (2), S1031-S1035 , 2012
    2012
    Citations: 118
  • Physico-chemical and structural characterization of mucilage isolated from seeds of Diospyros melonoxylon Roxb.
    S Singh, SB Bothara
    Brazilian Journal of Pharmaceutical Sciences 50, 713-725 , 2014
    2014
    Citations: 74
  • Formulation and evaluation of phytosome drug delivery system of boswellia serrata extract
    AR Sahu, SB Bothara
    Int J Res Med 4 (2), 94-99 , 2015
    2015
    Citations: 53
  • Preliminary pharmaceutical characterization of some flowers as natural indicator: acid-base titration
    S Singh, SB Bothara, S Singh, R Patel, R Ughreja
    Pharmacognosy journal 3 (22), 39-43 , 2011
    2011
    Citations: 44
  • Anti-inflammatory activity of Abutilon indicum extract
    P Tripathi, NS Chauhan, JR Patel
    Natural product research 26 (17), 1659-1661 , 2012
    2012
    Citations: 41
  • In vitro cytotoxicity evaluation of aqueous fruit and leaf extracts of Grewia asiatica using MTT assay
    B Marya, KH Dattani, DD Patel, PD Patel, D Patel, MP Suthar, VP Patel, ...
    Pharm. Chem 3, 282-287 , 2011
    2011
    Citations: 40
  • Anticonvulsant activity of Abutilon indicum leaf
    DK Golwala, LD Patel, SK Vaidya, SB Bothara, M Mani, P Patel
    Int. J. Pharm. Pharm. Sci 2 (1), 67-71 , 2010
    2010
    Citations: 40
  • Manilkara Zapota (Linn.) Seeds: A Potential Source of Natural Gum
    S Singh, SB Bothara
    ISRN Pharmaceutics 2014 (1), 1-6 , 2014
    2014
    Citations: 33
  • Ethnopharmacological properties of Cocculus hirsutus (L.) Diels-a review
    BH Marya, SB Bothara
    International Journal of Pharmaceutical Sciences Review and Research 7 (1 … , 2011
    2011
    Citations: 31
  • Effect of atorvastatin treatment on isoproterenol-induced myocardial infarction in rats
    CJ Trivedi, R Balaraman, JB Majithiya, SB Bothara
    Pharmacology 77 (1), 25-32 , 2006
    2006
    Citations: 27
  • A review on in vitro—In vivo mucoadhesive strength assessment
    S Singh, M Govind, SB Bothara
    PhaTechMed 2, 221-229 , 2013
    2013
    Citations: 25
  • Evaluation of aqueous extract of Ocimum sanctum in experimentally induced parkinsonism
    SV Joshi, SB Bothara, SJ Surana
    Journal of Chemical and Pharmaceutical Research 3 (1), 478-487 , 2011
    2011
    Citations: 25
  • Anti-obesity effect of Stellaria media methanolic extract in the murine model of cafeteria diet induced obesity
    VR Chidrawar, KN Patel, SB Bothra, SS Shiromwar, AR Koli, ...
    International Journal of Nutrition, Pharmacology, Neurological Diseases 2 (2 … , 2012
    2012
    Citations: 21
  • Solubility enhancement of nevirapine by cocrystallisation technique
    YK Nalte, VA Arsul, SG Shep, SB Bothara
    J. Pharm. Res 9 (8), 556-561 , 2015
    2015
    Citations: 19
  • Morphological, physico-chemical and structural characterization of mucilage isolated from the seeds of Buchanania lanzan Spreng
    S Singh, S Bothara
    International Journal of Health & Allied Sciences 3 (1), 33-33 , 2014
    2014
    Citations: 19
  • Acid-Base indicator properties of dyes from local flowers: Cassia aungostifolia Linn., Thevetia peruviana (pers.) K. Schum and Thevetia thvetiodes (Kunth) K. Schum
    S Singh, SB Bothara, S Singh
    Pharmacognosy Journal 3 (19), 35-39 , 2011
    2011
    Citations: 19
  • Pharmaceutical characterization of Cassia tora of seed mucilage in tablet formulations
    S Singh, SB Bothara, S Singh, RD Patel, NK Mahobia
    Scholars Research Library 2 (5), 54-61 , 2010
    2010
    Citations: 19
  • Analgesic activity of ethanolic leaf extract of Pavetta indica
    DK Golwala, LD Patel, SB Bothara, PM Patel, SK Vaidya, MK Raval
    Int. J. Pharm. Sci. Drug Res.,(1), 119-120 , 2009
    2009
    Citations: 18
  • AN ETHNO-PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW ON SOME UNEXPLORED MEDICINAL PLANTS BELONGS TO NORTH-EAST AND SOUTH-EAST REGION OF CHATTISHGARH
    BSB Vaidya SK
    European Journal of Pharmaceutical and Medical Research 1 (1), 240-261 , 2014
    2014
    Citations: 17
  • Pharmacognostical studies of seeds on some plants belonging Chhattisgarh
    SB Bothara, S Singh
    Pharmacognosy Journal 4 (28), 24-30 , 2012
    2012
    Citations: 15