Research in my group involve the synthesis, structural characterisation {elemental analysis, UV-VIS, FTIR, NMR, Electrochemistry, Fluorescence and single crystal x-ray analysis} of coordination complexes and their applications in biology
One-Dimensional Copper(II) Coordination Polymer Based on 1,2-bis-(4-Pyridyl) Ethane and 1,10-Phenathroline V. A. Kawade, S. S. Bhat, S. Naveen, N. K. Lokanath, R. J. Butcher Journal of Structural Chemistry, 2023 Abstract The one dimensional copper(II) coordination polymer {[Cu(phen)(bpe)(NO3)(H2O)](NO3)(H2O)}n (1) has been synthesized using [Cu(phen)2(NO3)2] (where phen = 1′10-phenanthroline and linker bpe = 1,2-bis-(4-pyridyl) ethane. Complex 1 was characterised by using elemental analysis, IR spectroscopy and single crystal X-ray diffraction analysis. The copper(II) ion is octahedrally coordinated with two nitrogen donor atoms from two bpe, two nitrogen donor atoms from phen, one oxygen donor atom from water and one oxygen donor atom from nitrato. Each 1D polymeric chain is connected to another chain via hydrogen bonding and π…π stacking interaction to form 3D network structures.
CHARACTERIZATION, CRYSTAL STRUCTURE, ANTICANCER AND ANTIOXIDANT ACTIVITY OF NOVEL N-(2-OXO-2-(10H-PHENOTHIAZIN-10-YL) ETHYL)PIPERIDINE-1-CARBOXAMIDE Manasa A. Doddagaddavalli, S. S. Bhat, J. Seetharamappa Journal of Structural Chemistry, 2023 Abstract A new compound, N-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)piperidine-1-carboxamide (PTZ–PIP) was synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (1H and 13C NMR) and mass spectrometry. The molecular structure of the compound (PTZ–PIP) was confirmed by single-crystal X-ray crystallographic studies. The compound (PTZ–PIP) was crystallized in a monoclinic crystal system with a space group of C2. The anticancer and antioxidant activity of the compound was investigated.
Co(II), Ni(II), Cu(II) and Zn(II) complexes of 1,8-naphthalimide-based ligand: syntheses, characterizations and evaluation of antibacterial activities Sabiha A. Shaikh, Satish S. Bhat, Vidyanand K. Revankar, Naveen S., Mahesha, N.K. Loknath, Vijay Kumbar Journal of Coordination Chemistry, 2023 Mononuclear later first-row transition metal complexes, [M(L)2] (1–4), where M = Co(II) (1), Ni(II) (2), Cu(II) (3), and Zn(II) (4) incorporating 1,8-naphthalimide based ligand were designed. The complex preparation was achieved by reacting metal nitrates with ligand (L) in 1:2 stoichiometry. The ligand and complexes were characterized with analytical and photophysical techniques. Single crystal X-ray diffraction determines that 3 is square planar. The complexes are highly fluorescent compared to the free ligand. The synthesized ligand (L) and complexes (1–4) were screened for their antibacterial activities against gram-positive [Streptococcus mutans (SM), Staphylococcus aureus (SA)] and gram-negative [Escherichia coli (EC), Klebsiella pneumoniae (KL)] bacterial strains. Ni(II) and Cu(II) complexes exhibited good activity against K. pneumonia and S. aureus compared to the free ligand. Particularly effective against gram-negative bacteria (Klebsiella pneumoniae), Ni(II) complex (2) has a MIC value of 6.25 µM and exhibits similar activity to standard ciprofloxacin. Cu(II) complex (3) is two times more effective than the common antibiotic ciprofloxacin with a MIC value of 3.125 µM against gram-positive bacteria (S. aureus).
Synthesis, crystal structure and biological properties of a fluorophore-labelled mixed-ligand copper(II) complex incorporating N-hydroxynaphthalene-1,8-dicarboximide Satish Shantaram Bhat, Vitthal A. Kawade, Vidyanand K. Revankar, Vijay Kumbar, Kishore Bhat Acta Crystallographica Section C Structural Chemistry, 2022 The mixed-ligand fluorophore-labelled copper(II) complex aqua[2,4-dioxo-3-azatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaen-3-olato-κ2 O 2,O 3](1,10-phenanthroline-κ2 N,N′)copper(II) nitrate, [Cu(C12H6NO3)(C12H8N2)(H2O)]NO3·CH3OH or [Cu(L)(phen)(H2O)]NO3·CH3OH (where phen is 1,10-phenanthroline and HL is N-hydroxynaphthalene-1,8-dicarboximide), (1), was synthesized and structurally characterized. The structure of (1) was confirmed by single-crystal X-ray structure determination. The complex crystallized in the triclinic space group P-1. The geometry around the copper centre is distorted square pyramidal, with the apical position occupied by a water molecule. The complex is highly fluorescent in organic and aqueous solutions. It has good anticancer activity, with an IC50 value of 17 µM, which is almost five times greater than cisplatin (IC50 = 82 µM) under identical experimental conditions.
Design, synthesis, crystal structure and spectral characterization of copper (II) complexes of the heterocyclic aroylhydrazones: Antimicrobial and antitubercular activity studies GS Hegde, SS Bhat, S Shaikh, V Kamat, VK Revankar Inorganica Chimica Acta 579, 122568 , 2025 2025 Citations: 6
Dinuclear copper (II) complexes bridged with acetate and nitrate anions: Study of protein binding and in-vitro anticancer activity SA Shaikh, SS Bhat, VK Revankar, S Naveen, NK Lokanath, V Kumbar Inorganica Chimica Acta 559, 121799 , 2024 2024 Citations: 8
Synthesis, crystal structure, DNA and protein binding study of N-(4-pyridyl)-1, 8-naphthalimide copper (II) complex SA Shaikh, SS Bhat, V Kamat, VK Revankar Inorganic Chemistry Communications 158, 111456 , 2023 2023 Citations: 7
Co (II), Ni (II), Cu (II) and Zn (II) complexes of 1, 8-naphthalimide-based ligand: syntheses, characterizations and evaluation of antibacterial activities SA Shaikh, SS Bhat, VK Revankar, N S, Mahesha, NK Loknath, V Kumbar Journal of Coordination Chemistry 76 (13-15), 1586-1603 , 2023 2023 Citations: 2
One-Dimensional Copper (II) Coordination Polymer Based on 1, 2-bis-(4-Pyridyl) Ethane and 1, 10-Phenathroline VA Kawade, SS Bhat, S Naveen, NK Lokanath, RJ Butcher Journal of Structural Chemistry 64 (7), 1341-1349 , 2023 2023 Citations: 2
Luminescent pyrene-based schiff base receptor for hazardous Mercury (II) detection demonstrated by cell imaging and test strip Chethanakumar, M Budri, KB Gudasi, RS Vadavi, SS Bhat Journal of Fluorescence 33 (2), 539-551 , 2023 2023 Citations: 26
Influence of counter ions on supramolecular structures of copper (II) complexes derived from 1, 8-naphthalimide tecton SA Shaikh, SS Bhat, PL Hegde, VK Revankar, K Kumara, NK Lokanath, ... Journal of Molecular Structure 1271, 134086 , 2023 2023 Citations: 6
Synthesis, crystal structure and biological properties of a fluorophore-labelled mixed-ligand copper (II) complex incorporating N-hydroxynaphthalene-1, 8-dicarboximide SS Bhat, VA Kawade, VK Revankar, V Kumbar, K Bhat Crystal Structure Communications 78 (12), 755-759 , 2022 2022
Synthesis, Characterization and DNA Cleavage Activity of the Coordination Polymer {[Cu(phen)(azpy)(NO 3 )(H 2 O)]·(NO 3 )} n MB Baraskar, VA Kawade, SS Bhat, RJ Butcher, M Mohite, N Deshmukh, ... Journal of Chemical Crystallography 52 (4), 494-502 , 2022 2022 Citations: 1
Syntheses, structural characterization and evaluation of the anti-tubercular activity of copper (II) complexes containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone PL Hegde, SS Bhat, VK Revankar, SA Shaikh, K Kumara, L NK Journal of Molecular Structure 1257, 132589 , 2022 2022 Citations: 19
Synthesis, characterization and biological properties of Ruthenium (II) polypyridyl complexes containing 2 (1H)-quinolinone-3 (1H-imidazo [4, 5f][1, 10] phenanthrolin-2-yl SS Bhat, VK Revankar, RV Pinjari, V Kumbar, K Bhat, VA Kawade Inorganic Chemistry Communications 138, 109260 , 2022 2022 Citations: 8
Synthesis, structural characterization and biological properties of cyclometalated iridium (III) complexes containing 2-methyl-3-{(E)-[(quinolin-2-yl) methylidene] amino … RS Vadavi, SS Bhat, VK Revankar, KB Gudasi, NK Lokanath, RV Pinjari, ... Inorganica Chimica Acta 531, 120735 , 2022 2022 Citations: 2
Syntheses and structural characterization of metal complexes of 4-(naphthalen-1-yl)-1-(quinolin-2-yl)methylene)thiosemicarbazide: their in-vitro screening studies … PL Hegde, K Naik, SS Bhat, SA Shaikh, RJ Butcher, N S, NK Lokanath, ... Journal of Coordination Chemistry 74 (17-20), 3018-3030 , 2022 2022
Copper (I) complexes with quinolone appended 1, 8-naphthalimide conjugates: structural characterization, DNA and protein binding and cytotoxicity studies SA Shaikh, SS Bhat, VK Revankar, K Kumara, NK Lokanath, RJ Butcher, ... New Journal of Chemistry 46 (35), 16801-16812 , 2022 2022 Citations: 5
Fluorophore tagged mixed ligand copper (II) complexes: synthesis, structural characterization, protein binding, DNA cleavage and anticancer activity SA Shaikh, SS Bhat, VK Revankar, BD Kulkarni, K Kumara, NK Lokanath, ... ChemistrySelect 6 (45), 12666-12676 , 2021 2021 Citations: 4
The Co (II), Ni (II), Cu (II) and Zn (II) complexes of aroylhydrazone of quinolone core: syntheses, characterization and evaluation of antimicrobial and antitubercular activity GS Hegde, SS Bhat, SP Netalkar, PL Hegde, A Kotian, RJ Butcher, ... Inorganica Chimica Acta 522, 120352 , 2021 2021 Citations: 18
A new modified ridge regression estimator S Bhat Comm. Statist. Theory Methods 50 (10), 2227-2242 , 2021 2021 Citations: 2
Synthesis, structural characterization, protein binding, DNA cleavage and anticancer activity of fluorophore labelled copper (II) complexes based on 1, 8-naphthalimide conjugates SA Shaikh, SS Bhat, PL Hegde, VK Revankar, A Kate, D Kirtani, ... New Journal of Chemistry 45 (35), 16319-16332 , 2021 2021 Citations: 19
Synthesis, Structural Characterization and Hirshfeld Surface Analysis of Mixed Ligand Copper (II) Complex NA Shaikh, SN Rathod, SS Bhat, S Shaikh, VK Revankar, NK Lokanath Chemical Data Collections 28, 100374 , 2020 2020 Citations: 2
Highly sensitive and selective colorimetric probe for detection of Cu2+ in aqueous medium based on rhodamine B SS Bhat, A Kotian, S Shaikh, PL Hegde, RV Pinjari, VK Revankar Chemical data collections 26, 100359 , 2020 2020 Citations: 7
MOST CITED SCHOLAR PUBLICATIONS
Synthesis, electronic structure, DNA and protein binding, DNA cleavage, and anticancer activity of fluorophore-labeled copper (II) complexes SS Bhat, AA Kumbhar, H Heptullah, AA Khan, VV Gobre, SP Gejji, ... Inorganic chemistry 50 (2), 545-558 , 2011 2011 Citations: 299
Nonheme Fe (IV) oxo complexes of two new pentadentate ligands and their hydrogen-atom and oxygen-atom transfer reactions M Mitra, H Nimir, S Demeshko, SS Bhat, SO Malinkin, M Haukka, ... Inorganic Chemistry 54 (15), 7152-7164 , 2015 2015 Citations: 92
Ruthenium (II) polypyridyl complex as inhibitor of acetylcholinesterase and Aβ aggregation NA Vyas, SS Bhat, AS Kumbhar, UB Sonawane, V Jani, RR Joshi, ... European Journal of Medicinal Chemistry 75, 375-381 , 2014 2014 Citations: 89
A phosphate-targeted dinuclear Cu (II) complex combining major groove binding and oxidative DNA cleavage Z Molphy, D Montagner, SS Bhat, C Slator, C Long, A Erxleben, A Kellett Nucleic acids research 46 (19), 9918-9931 , 2018 2018 Citations: 66
Self-association of ruthenium (II) polypyridyl complexes and their interactions with calf thymus DNA SS Bhat, AS Kumbhar, P Lönnecke, E Hey-Hawkins Inorganic chemistry 49 (11), 4843-4853 , 2010 2010 Citations: 61
Efficient dna condensation induced by ruthenium (II) complexes of a bipyridine‐functionalized molecular clip ligand SS Bhat, AS Kumbhar, AA Kumbhar, A Khan Chemistry–A European Journal 18 (51), 16383-16392 , 2012 2012 Citations: 55
Synthesis, crystal structure and biological properties of a cis-dichloridobis (diimine) copper (II) complex SS Bhat, VK Revankar, V Kumbar, K Bhat, VA Kawade Crystal Structure Communications 74 (2), 146-151 , 2018 2018 Citations: 54
Ruthenium (II) polypyridyl complexes as carriers for DNA delivery SS Bhat, AS Kumbhar, AA Kumbhar, A Khan, P Lönnecke, ... Chemical Communications 47 (39), 11068-11070 , 2011 2011 Citations: 44
Effect of long term administration of aluminium chloride on oxidative stress and acetylcholinesterase activity in rat brains NR Naidu, S Bhat, U Dsouza Int J Pharm Bio Sci 3 (1), 616-22 , 2013 2013 Citations: 34
Highly enantioselective epoxidation of olefins by H 2 O 2 catalyzed by a non-heme Fe (ii) catalyst of a chiral tetradentate ligand M Mitra, O Cusso, SS Bhat, M Sun, M Cianfanelli, M Costas, E Nordlander Dalton Transactions 48 (18), 6123-6131 , 2019 2019 Citations: 31
Luminescent pyrene-based schiff base receptor for hazardous Mercury (II) detection demonstrated by cell imaging and test strip Chethanakumar, M Budri, KB Gudasi, RS Vadavi, SS Bhat Journal of Fluorescence 33 (2), 539-551 , 2023 2023 Citations: 26
Tris-heteroleptic ruthenium (II) polypyridyl complexes: synthesis, structural characterization, photophysical, electrochemistry and biological properties SS Bhat, AS Kumbhar, N Purandare, A Khan, G Grampp, P Lönnecke, ... Journal of Inorganic Biochemistry 203, 110903 , 2020 2020 Citations: 24
Synthesis, crystal structure and cytotoxicity studies of cis-dichloro (4, 5-diazafluoren-9-one) platinum (II) AR Biju, MV Rajasekharan, SS Bhat, AA Khan, AS Kumbhar Inorganica Chimica Acta 423, 93-97 , 2014 2014 Citations: 23
Syntheses, structural characterization and evaluation of the anti-tubercular activity of copper (II) complexes containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone PL Hegde, SS Bhat, VK Revankar, SA Shaikh, K Kumara, L NK Journal of Molecular Structure 1257, 132589 , 2022 2022 Citations: 19
Synthesis, structural characterization, protein binding, DNA cleavage and anticancer activity of fluorophore labelled copper (II) complexes based on 1, 8-naphthalimide conjugates SA Shaikh, SS Bhat, PL Hegde, VK Revankar, A Kate, D Kirtani, ... New Journal of Chemistry 45 (35), 16319-16332 , 2021 2021 Citations: 19
A class of generalized ridge estimators S Bhat, V Raju Communications in Statistics-Simulation and Computation 46 (7), 5105-5112 , 2017 2017 Citations: 19
The Co (II), Ni (II), Cu (II) and Zn (II) complexes of aroylhydrazone of quinolone core: syntheses, characterization and evaluation of antimicrobial and antitubercular activity GS Hegde, SS Bhat, SP Netalkar, PL Hegde, A Kotian, RJ Butcher, ... Inorganica Chimica Acta 522, 120352 , 2021 2021 Citations: 18
Luminescent ruthenium (II) polypyridyl complexes as nonviral carriers for DNA delivery SS Bhat, VK Revankar, A Khan, RV Pinjari, M Necas Chemistry–An Asian Journal 12 (2), 254-264 , 2017 2017 Citations: 18
Supramolecular architecture and photophysical and biological properties of Ruthenium (II) polypyridyl complexes SS Bhat, VK Revankar, A Khan, RJ Butcher, K Thatipamula New Journal of Chemistry 39 (5), 3646-3657 , 2015 2015 Citations: 17
Synthesis, structural characterization and biological properties of phosphorescent iridium (III) complexes SS Bhat, N Shivalingegowda, VK Revankar, NK Lokanath, MS Kugaji, ... Journal of Inorganic Biochemistry 177, 127-137 , 2017 2017 Citations: 16
