Lithopedion—a rare complication of abdominal pregnancy: a clinical case report Avni Kryeziu, Astrit M. Gashi, Lavdim Ymeri, Shend Kryeziu, Fatlinda Berisha, et al. Oxford Medical Case Reports, 2025 Lithopedion (from the Greek words 'lithos' meaning stone and 'paidion' meaning child) refers to a rare medical complication in which a fetus dies during an abdominal pregnancy and, unable to be absorbed by the body, calcifies and is gradually turned into stone. This process of calcification serves as the body's way of protecting itself from the dead tissue, preserving the fetus inside the mother's abdomen for many years, often without any symptoms. Lithopedion cases are extremely rare, with about 330 to 340 documented cases reported throughout 400 years of medical literature. We report a rare clinical case of retained abdominal pregnancy for decades in a 70-year-old postmenopausal female, who presented with chronic back pain. Multiple fetal bones calcified in the abdomen were observed on computed tomography.
A Retrospective Study to Compare Serum Uric Acid Levels in Women with Preeclampsia and Pregnancy-Induced Hypertension and Normotensive Pregnant Women Lindita Ibrahimi, Brikene Dacaj Elshani, Albana Gashi, Elira Nuraj International Journal of Biomedicine, 2025 Background: This study aimed to compare serum uric acid (sUA) levels in 59 women with preeclampsia (PE), 61 women with pregnancy-induced hypertension (PIH), and 80 normotensive women at 24–34 weeks of gestation. Methods and Results: This case-control study included 200 pregnant women at the Obstetrics and Gynecology Clinic, University Clinical Center of Kosovo. Groups comprised 59 PE patients, 61 PIH patients, and 80 normotensive controls. SUA levels were measured and analyzed for statistical significance. Preeclampsia was diagnosed based on criteria of the International Society for the Study of Hypertension in Pregnancy, which include hypertension onset after 20 weeks of gestation and significant proteinuria. Pregnancy-induced hypertension was identified as hypertension after 20 weeks of gestation without proteinuria. Serum uric acid levels were quantified using enzymatic methods with validated laboratory equipment. Significant differences in serum uric acid levels were found among groups (P=0.0000). PE patients had the highest sUA levels (326.1±64.3 µmol/L) compared to PIH (263.3±60.3 µmol/L; P=0.0000) and normotensive women (232.6±44.3 µmol/L; P=0.0000). Sensitivity and specificity for PE detection were 96.6% and 48.8%, respectively, with ROC analysis confirming predictive value (AUC:0.857) Conclusion: Elevated sUA levels are strongly associated with preeclampsia and demonstrate high sensitivity for detecting it. This finding highlights the potential of sUA as a valuable biomarker for early identification and management of preeclampsia, enabling timely interventions to improve maternal and fetal outcomes.
The atypical presentation of uterine scar rupture covered by hematoma – A case report with a favorable prognosis , Astrit M. Gashi, , Dielleza Lleshi, , Ferdeze Haxhijaha, , Albulena Gashi, , and Romanian Medical Journal, 2025 Uterine rupture is a rare but life-threatening obstetric emergency, particularly in women with a history of previous cesarean sections. We present a unique case of uterine scar rupture at 36 weeks of gestation, where the rupture was covered by a hematoma, leading to a favorable outcome for both the mother and the baby. A 35-year-old woman with a history of three prior cesarean sections presented with mild lower abdominal pain and decreased fetal movements. Ultrasound revealed a hematoma in the lower uterine segment near the previous scar, raising suspicion of uterine rupture. An emergency cesarean section confirmed a 5 cm rupture in the lower uterine segment, which was sealed by a large hematoma, limiting significant hemorrhage. The uterine defect was repaired, and both the mother and baby recovered without complications. This case underscores the importance of timely diagnosis and surgical intervention in uterine rupture cases and demonstrates that a hematoma covering the rupture can delay catastrophic outcomes, allowing for a more favorable prognosis.
Omphalomesenteric Duct Remnant: A Case Report Faton Krasniqi, Kujtim Ukperaj, Astrit Gashi, Isabere Krasniqi, Vita Krasniqi International Journal of Biomedicine, 2024 The ductus omphaloentericus, also known as the ductus vitellinus or omphalomesenteric duct (OMD), is an embryonic structure that connects the yolk sac to the midgut lumen of the developing fetus.OMD plays a crucial role in early fetal development by transferring nutrients from the yolk sac to the growing embryo.The OMD usually involutes between the seventh and ninetieth week of fetal development.However, if the duct fails to regress completely, remnants can persist, leading to congenital anomalies that can lead to complications like bleeding, inflammation, or obstruction.Treatment typically involves surgical intervention to remove or correct the anomaly.We present a 15-day-old male newborn who was referred to the emergency department with an umbilical lump protruding from the umbilicus, which raised suspicion of an omphalocele.Surgical exploration was undertaken, and the OMD was found and excised.After improving the clinical condition, on the 10-day hospital stay, the newborn was discharged home without complications.
Unintended Consequences: Exploring Iatrogenic Injuries in Cesarean Section Deliveries Sahadete Shala, Merita Krasniqi, Astrit Gashi International Journal of Biomedicine, 2024 Cesarean delivery (CD), or C-section, which prevents injury and death in mothers and babies at higher risk of complicated deliveries, like any surgery, does carry a risk of complications. By reviewing the medical literature and analyzing documented CD cases, we examined the spectrum of iatrogenic injuries, including unintentional injuries, affecting both maternal and neonatal outcomes. This case report describes iatrogenic bladder damage after CD in a 31-year-old woman who had a previous emergency CD two years ago. This case calls for a comprehensive approach to minimize iatrogenic risks and optimize maternal and neonatal well-being during repeat СD.
Harlequin Ichthyosis – Genetic and Dermatological Challenges: A Case Report and Literature Review Brikene Elshani, Astrit Gashi, Besa Selimi, Arion Elshani International Journal of Biomedicine, 2024 Harlequin ichthyosis (HI) is an extremely rare and severe genetic skin disorder characterized by thick, diamond-shaped scales covering the body, often giving the appearance of a harlequin costume. This paper provides an overview of the genetic and dermatological aspects of HI, delving into its etiology, clinical manifestations, and management. The genetic underpinnings of HI involve mutations in the ABCA12 gene, leading to impaired skin barrier function and abnormal keratinization. Understanding the molecular basis of the disorder is crucial for accurate diagnosis and potential therapeutic interventions. Clinically, HI presents challenges related to skin integrity, thermoregulation, and potential complications, such as infections. The management of HI requires a multidisciplinary approach involving dermatologists, geneticists, and other healthcare professionals. Supportive care, including emollients, careful bathing, and prevention of infections, is essential to improve the quality of life for individuals affected by this condition. Despite its rarity and severity, advancements in medical research and genetic therapies offer hope for improved treatments and interventions. This paper aims to contribute to the collective understanding of HI, fostering ongoing research and compassionate care for those living with this unique and challenging dermatological condition. We presented a premature eutrophic harlequin baby, born at 32+ weeks of gestation via emergency C-section. A clinical diagnosis was established minutes after birth, based on the typical features of HI, from scaly skin, marked fissures, and limbs in flexion contractures to prominent eclabium and bilateral ectropion.
Therapeutic potential of inositol to PCOS: An overview of administration, efficacy, and potential applications Astrit M. Gashi and Romanian Medical Journal, 2024 Inositol, a group of naturally occurring sugar alcohols, has gained attention for the diverse physiological roles and therapeutic potential. This comprehensive overview examines the administration, efficacy, and potential applications of inositol in various medical contexts. Myo-inositol and D-chiro inositol are the two types of inositol covered in this review, exploring their mechanisms of action and biochemical pathways. Discussions on the administration methods, including supplements and dietary sources, provide insights into optimizing therapeutic outcomes. The review also explores the available data on the effectiveness of inositol in treating diseases like mental health disorders, metabolic disorders, and polycystic ovarian syndrome (PCOS). Furthermore, potential reproductive medicine, neurology, and other areas of applications are explored. This overview provides a comprehensive snapshot of the evolving landscape of inositol research, emphasizing its promising role in various therapeutic interventions and prompting further exploration of its multifaceted benefits.
The long-term neurological consequences of congenital Zika Syndrome to Zika-Infected maternal during pregnancy-A narrative review Astrit M. Gashi and Romanian Journal of Neurology Revista Romana De Neurologie, 2023 Background. Congenital Zika Syndrome presents a significant public health concern, particularly due to its association with severe neurological complications in infants born to maternal infected with the Zika virus during pregnancy. This article offers a comprehensive overview of the risks, complications, and preventive measures associated with Zika virus infection during pregnancy. Methods. A thorough literature search was conducted, encompassing studies, case reports, and clinical observations related to neurological complications in infants with congenital Zika syndrome. The review focuses on elucidating the intricate relationship between maternal Zika virus infection and the subsequent neurological challenges faced by newborns. Results. The neurological impacts of congenital Zika syndrome are multifaceted, ranging from the well-documented microcephaly to less explored manifestations such as brain abnormalities, ventriculomegaly, intracranial calcifications, seizures, and sensory impairments. Additionally, joint and limb contractures contribute to the complexity of congenital Zika syndrome-related neurological deficits. This narrative review synthesizes current knowledge on the subject, shedding light on the diverse ways in which Zika virus infection during pregnancy can affect the developing fetal nervous system. Conclusion. Understanding the intricate neurological complications associated with congenital Zika syndrome is crucial for healthcare practitioners, researchers, and policymakers. This review provides a comprehensive overview of the current state of knowledge, emphasizing the need for continued research, surveillance, and public health interventions to mitigate the impact of the Zika virus on maternal and child health.
Consequences of antiphospholipid syndrome in pregnancy-A review Astrit M. Gashi, , and Romanian Journal of Rheumatology, 2023 Background and objectives. Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPL) in the blood. Antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies, including lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies. These antibodies target phospholipids-binding proteins and can leading to various clinical manifestations and complications of thromboembolic nature. Also, the antiphospholipid syndrome is strongly linked to adverse pregnancy outcomes, including recurrent miscarriages, fetal growth restriction, preeclampsia, and preterm birth. Placental dysfunction, impaired blood flow to the fetus, and thrombotic events within the placenta contribute to these complications. The purpose of this review was the research of consequences of antiphospholipid syndrome in pregnancy. Materials and methods. This research involves systematically reviewing and analyzing existing literature on consequences of antiphospholipid syndrome in pregnancy. For relevant literature, academic databases like Pub Med, Scopus, Web of Science, and Google Scholar were used. Search terms and keywords that were used to search for relevant literature in databases was: antiphospholipid syndrome; pregnancy; consequences, and Boolean operator (AND, OR). The criteria used to include literature in this review were; publication date, language, study objectives, study design, research methodology, key findings, and relevance to my research question. For citation and referencing were used the appropriate citation style (e.g., APA, MLA, Chicago, Harvard and Vancouver). Results. The main findings in this review were that antiphospholipid syndrome (APS) of characterizing by dysregulation of the immune system and the production of autoantibodies. These autoantibodies can target various cells and proteins, leading to inflammation, tissue damage, and disrupted physiological processes. This syndrome is associated with a prothrombotic state, increasing the risk of blood clots in veins and arteries. Antiphospholipid syndrome (APS) can affect multiple organs and systems, including the skin, kidneys, heart, and central nervous system. Thrombotic events can occur in various organs, leading to deep vein thrombosis, pulmonary embolism, strokes, and other thromboembolic complications. Also, the antiphospholipid syndrome is strongly linked to adverse pregnancy outcomes, including recurrent miscarriages, fetal growth restriction, preeclampsia, and preterm birth. Placental dysfunction, impaired blood flow to the fetus, and thrombotic events within the placenta contribute to these complications. Manifestations may include skin rashes (livedo reticularis), kidney involvement (glomerulonephritis), heart valve abnormalities, and neurological symptoms etc. Conclusions. We come to the conclusion that it is essential for the pregnant women with antiphospholipid syndrome to receive close monitoring and appropriate management to reduce the risk and severity of these pregnancy complications. This may include interventions such as anticoagulation therapy, regular prenatal care, monitoring of fetal growth and wellbeing, and prompt management of complications. A multidisciplinary approach involving obstetricians, rheumatologists, and other healthcare professionals is often necessary to optimize outcomes for both the mother and the baby.
Recommendations for Prenatal Doppler in Daily Obstetric Practice - A Review Astrit M. GASHI and Medicina Moderna, 2023 Doppler fluximetry in obstetrics refers to the use of Doppler ultrasound technology to assess blood flow patterns and velocities in the maternal and fetal circulations during pregnancy. It provides valuable information about the vascular dynamics in the p
Neurofibromatosis type 1 (Nf1) and pregnancy - Case with positive outcomes Journal of Krishna Institute of Medical Sciences University, 2018
Meningioma in pregnancy and perinatal outcomes Astrit M. Gashi, , Jakup Ismajli, Curr Gjocaj, Atdhe Keqa, Visare Batalli, Qefsere Mulaj, , , , , and Romanian Journal of Neurology Revista Romana De Neurologie, 2018
Postpartum hemorrhage post placenta previa centralis-conservative management Obstetrica Si Ginecologie, 2016
The woman with severe preeclampsia who died from postpartum complications Revista Cubana De Obstetricia Y Ginecologia, 2016
RECENT SCHOLAR PUBLICATIONS
Lithopedion—a rare complication of abdominal pregnancy: a clinical case report A Kryeziu, A Gashi, L Ymeri, S Kryeziu, F Berisha, V Kryeziu, L Sijarina, ... Oxford Medical Case Reports 2025 (11), omaf230 , 2025 2025 Citations: 1
A Retrospective Study to Compare Serum Uric Acid Levels in Women with Preeclampsia and Pregnancy-Induced Hypertension and Normotensive Pregnant Women L Ibrahimi, BD Elshani, A Gashi, E Nuraj Int J Biomed 15 (1), 129-34 , 2025 2025 Citations: 1
The atypical presentation of uterine scar rupture covered by hematoma–A case report with a favorable prognosis. AM Gashi, D Lleshi, F Haxhijaha, A Gashi Romanian medical JouRnal 72 (1) , 2025 2025
Couvelaire Syndrome: A Case Report and Literature Review AMGS Fetiu Romanian Journal of Military Medicine Revista de Medicină Militară 1222 … , 2024 2024
Therapeutic potential of inositol to PCOS: An overview of administration, efficacy, and potential applications AM Gashi Romanian medical JouRnal 71 (1), 37 , 2024 2024 Citations: 1
The long-term neurological consequences of congenital Zika Syndrome to Zika-Infected maternal during pregnancy - A narrative review AM Gashi ROMANIAN JOURNAL OF NEUROLOGY 22 (4), 289-296 , 2023 2023
Chorea Gravidarum: narrative review. AM Gashi, J Ismajli, A Sherifi Romanian Journal of Family Medicine/Revista Română de Medicina Familiei 6 (4) , 2023 2023 Citations: 2
Aspirin use in obstetrics and gynecology: a comprehensive review of applications and considerations AM GASHI, B ELSHANI Romanian JouRnal of medical PRactice 18 (4), 97 , 2023 2023 Citations: 1
Recommendations for Prenatal Doppler in Daily Obstetric Practice-A Review. AM GASHI Medicina Moderna 30 (4) , 2023 2023
Quality of life in cancer patients – A systematic review AMG Vlora Ejupi, Nexhmije Gori Romanian Medical Journal 70 (2), 59-70 , 2023 2023 Citations: 1
Consequences of antiphospholipid syndrome in pregnancy - A review AM Gashi Romanian Journal of Rheumatology 32 (2), 49-55 , 2023 2023 Citations: 3
The Prevalent Cases of Endometrial Carcinoma in Different Life Periods of Women-Clinical and Histopathological Diagnosis H Latifi, AM Gashi, D Latifi Current Health Sciences Journal 49 (2), 151 , 2023 2023 Citations: 2
Necrotizing fasciitis: A challenging obstetric emergency S Shala, M Krasniqi, B Elshani, AM Gashi, J Luta, B Selimi, ... Mortality 3 (16), 17 , 2023 2023 Citations: 1
Beckwith-Wiedemann syndrome: deciphering the genetic and clinical complexity-a case report with literature review AM Gashi, B Elshani Rom J Pediatr 72, 206-10 , 2023 2023 Citations: 1
Prevalence of Trichomonas vaginalis infection in women of reproductive age in Kosovo. AM Gashi, H Latifi, B Elshani Obstetrică şi Ginecologie 71 (1) , 2023 2023
Expression of PD/PD-L1 as a Prognostic Bio-marker in Ovarian Serous carcinoma Carcinoma-A Literature Review. AM Gashi, B Elshani, H Latifi, G Sopa, J Ismajli, A Sherifi Onkologia i Radioterapia 16 (5) , 2022 2022
Expression of PD/PD-L1 as a prognostic bio-marker in ovarian serous carcinoma-A literature review AM Gashi, B Elshani, H Latifi, G Sopa, JIA Sherifi immunity 16, 18 , 2022 2022 Citations: 2
Anxiety scale in surgical abortions and drug-induced abortions: A comparative study HL Astrit M.Gashi, Drilon Latifi Romanian Journal of Neurology/ Revista Romana de Neurologie 20 (4, 2021 … , 2021 2021 Citations: 1
Osteoporosis during Pregnancy-Case Report and Review AM Gashi, J Ismajli, I Berisha, B Elshani, B Rraci, A Berisha Rheumatology (Bulgaria) 29 (2), 85-90 , 2021 2021 Citations: 1
article The birth rate in adolescent girls in Kosovo A Gashi 2021
MOST CITED SCHOLAR PUBLICATIONS
Case report of severe preeclampsia and associated postpartum complications M Pacarada, A Gashi, A Beha, B Obertinca J Case Rep Stud 4 (suppl 4), 408 , 2016 2016 Citations: 10
Anxiety, Depression and other Psychological effects on Women after Induced Abortion O Bujar, M Pacarada, AB Beha, F Gallopeni, N Kongjeli, A Gashi Public Health and Preventive Medicine 2016, 2 , 2016 2016 Citations: 6
The woman with severe preeclampsia who died from postpartum complications AM Gashi Revista Cubana de Obstetricia y Ginecología 42 (4), 519-523 , 2016 2016 Citations: 5
Emotional and Psychological Effects on Women after Induced Abortion VB Bujar Obertinca,2AfrimDangellia,4Myrvete Pacarada,4Albiona Beselica Beha ... International Journal of Science and Research (IJSR) 5 (3), 1785-1788 , 2016 2016 Citations: 5
Trichomonas Vaginalis-A Clinical Image AM Gashi Archives of Case Reports 1 (1), 001-002 , 2017 2017 Citations: 4
Consequences of antiphospholipid syndrome in pregnancy - A review AM Gashi Romanian Journal of Rheumatology 32 (2), 49-55 , 2023 2023 Citations: 3
Non-immunologic hydrops fetalis and coronavirus disease (COVID-19)-A case report F Krasniqi, E Pistulli, A Gashi, I Krasniqi Romanian Journal of Pediatrics 70 (1), 75-79 , 2021 2021 Citations: 3
Neurofibromatosis Type 1 (Nf1) and Pregnancy-Case With Positive Outcomes AM Gashi¹, C Gjocaj, J Ismajli¹, X Gojnovci 2018 Citations: 3
Chorea Gravidarum: narrative review. AM Gashi, J Ismajli, A Sherifi Romanian Journal of Family Medicine/Revista Română de Medicina Familiei 6 (4) , 2023 2023 Citations: 2
The Prevalent Cases of Endometrial Carcinoma in Different Life Periods of Women-Clinical and Histopathological Diagnosis H Latifi, AM Gashi, D Latifi Current Health Sciences Journal 49 (2), 151 , 2023 2023 Citations: 2
Expression of PD/PD-L1 as a prognostic bio-marker in ovarian serous carcinoma-A literature review AM Gashi, B Elshani, H Latifi, G Sopa, JIA Sherifi immunity 16, 18 , 2022 2022 Citations: 2
Borderline Ovarian Tumor and Pregnancy AM GASHI, J ISMAJLI, X GOJNOVCI Romanian Journal of Medical Practice 14 (1) , 2019 2019 Citations: 2
The impact of assisted reproductive technology (ART), to the increasing incidence of the high order multiple pregnancies AM Gashi, S Fetiu, M Ramosaj Gynecol Obstet (Sunnyvale) 5 (302), 2161-0932.1000302 , 2015 2015 Citations: 2
Lithopedion—a rare complication of abdominal pregnancy: a clinical case report A Kryeziu, A Gashi, L Ymeri, S Kryeziu, F Berisha, V Kryeziu, L Sijarina, ... Oxford Medical Case Reports 2025 (11), omaf230 , 2025 2025 Citations: 1
A Retrospective Study to Compare Serum Uric Acid Levels in Women with Preeclampsia and Pregnancy-Induced Hypertension and Normotensive Pregnant Women L Ibrahimi, BD Elshani, A Gashi, E Nuraj Int J Biomed 15 (1), 129-34 , 2025 2025 Citations: 1
Therapeutic potential of inositol to PCOS: An overview of administration, efficacy, and potential applications AM Gashi Romanian medical JouRnal 71 (1), 37 , 2024 2024 Citations: 1
Aspirin use in obstetrics and gynecology: a comprehensive review of applications and considerations AM GASHI, B ELSHANI Romanian JouRnal of medical PRactice 18 (4), 97 , 2023 2023 Citations: 1
Quality of life in cancer patients – A systematic review AMG Vlora Ejupi, Nexhmije Gori Romanian Medical Journal 70 (2), 59-70 , 2023 2023 Citations: 1
Necrotizing fasciitis: A challenging obstetric emergency S Shala, M Krasniqi, B Elshani, AM Gashi, J Luta, B Selimi, ... Mortality 3 (16), 17 , 2023 2023 Citations: 1
Beckwith-Wiedemann syndrome: deciphering the genetic and clinical complexity-a case report with literature review AM Gashi, B Elshani Rom J Pediatr 72, 206-10 , 2023 2023 Citations: 1
