assem antar abdelalim mohamed

Scopus Publications

Foamable pluroleosomes system loaded with amlodipine as a repurposed antibacterial topical formulation against MRSA-induced infection; optimization, in-vitro, ex-vivo, and in-vivo studies
Alaa S. Eita, Amna M.A. Makky, Asem Anter, Islam A. Khalil
International Journal of Pharmaceutics X, 2025
Coated Zein Polymeric Nanoparticles Loaded with Amlodipine as a Repurposed Antibacterial Ocular Cure for MRSA-Induced Infection: Optimization, In Vitro, Ex Vivo, and In Vivo Assessments
Alaa S. Eita, Amna M. A. Makky, Asem Anter, Islam A. Khalil
Pharmaceutics, 2025
Background: Amlodipine besylate (AML) is recognized as a calcium channel blocker curative for hypertension. However, the drug emerged recently as an antibacterial cure that competently prevails over resistant strains. Methods: Incorporating amlodipine into zein nanoparticles was employed to innovate a suitable carrier for loading and targeting deep corneal infection. The Box–Behnken design was adopted to produce various formulations of amlodipine-loaded zein nanoparticles (AML-ZNs) with diversity in composition concentration (% w/v), comprising zein, Labrafac, and poloxamer 407. Results: Relying on the optimization criterion, the chosen preference formulation concentration (% w/v) consists of 2.068 for zein, 0.75 for Labrafac, and 1.0 for Poloxamer. Morphological micrography of AML-ZNs showed regular spherical particles in the nanometric scale, and physicochemical characterization procedures confirmed system suitability. While tracking eyedrop optimum features, sodium alginate was selected for coating nanoparticles to improve stability and system viscosity. Both pH and sterility were also considered and maintained. Comparative studies were conducted pre- and post-coating, and the assessed features for the final selected formulation were 349.9 ± 5.8 nm, 0.2186 ± 0.0271, −55.45 ± 1.84 mV, 81.293 ± 0.9%, and 19.3 ± 0.19 cp for size, PDI, surface charge, entrapment, and viscosity, respectively. The AML-ZNs-Alg formulation demonstrates a more controlled pattern of release of roughly 40% of the drug released after 48 h, while the permeation profile shows 37 ± 3.52% permeated after 24 h, confirmed visually. In vitro microbial assay alongside the corneal in vivo microbial and histological pathology evaluation proved the efficacy of amlodipine as an antibacterial agent. Conclusions: These findings highlighted that the prepared AML-ZNs-Alg eyedrop can be a promising system as an antibacterial therapy.
Anticariogenic efficacy of Indian Costus mouthwash in children
Ghada Salem, Maryam ElMansy, Eman Allam, Asem Anter, Rehab Abdelmonem, et al.
Journal of Herbal Medicine, 2025
Corneal targeted Amorolfine HCl-mixed micelles for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments
Eman M. Abd-Elmonem, Amna M.A. Makky, Assem Antar, Wessam H. Abd-Elsalam, Islam A. Khalil
Journal of Drug Delivery Science and Technology, 2023
Inhalable vancomycin-loaded lactose microparticles for treatment of MRSA pneumonia
Moustafa M. Abdelaziz, Amr Hefnawy, Asem Anter, Menna M. Abdellatif, Mahmoud A.F. Khalil, et al.
Journal of Drug Delivery Science and Technology, 2023
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation
Alaa S. Eita, Amna M.A. Makky, Asem Anter, Islam A. Khalil
International Journal of Pharmaceutics X, 2022
Silica-Coated Magnetic Nanoparticles for Vancomycin Conjugation
Moustafa M. Abdelaziz, Amr Hefnawy, Asem Anter, Menna M. Abdellatif, Mahmoud A. F. Khalil, et al.
ACS Omega, 2022
Nanoparticles Loaded Thermoresponsive In Situ Gel for Ocular Antibiotic Delivery against Bacterial Keratitis
Muhammad Naseer Abbas, Saeed Ahmad Khan, Sajid Khan Sadozai, Islam A. Khalil, Asem Anter, et al.
Polymers, 2022
Antibiotics delivered through conventional dosage against ophthalmic infections show lower therapeutic efficacy due to their low residence time. Therefore, there is a great need to design and develop novel dosage forms that would increase the ocular residence time of antibiotics at the site of infection. This study describes the development of nanoparticles laden in situ gelling solution, intended to sustain antibiotic release for improved therapeutic efficiency. Oxytetracycline-loaded gelatin-polyacrylic acid nanoparticles were prepared and incorporated in poloxamer-N407 solution. The rheological properties of the system were studied concerning time and temperature. Moreover, in vivo biocompatibility of the system was ascertained using the Draize test and histological studies. Finally, the optimized formulation was evaluated for in vitro antibacterial activity against one of the most common keratitis causing bacteria, Pseudomonas aeruginosa. Additionally, the in vivo efficacy was evaluated on the rabbit’s eye conjunctivitis model. The formulation showed a sustained effect against keratitis; furthermore, the antibacterial activity was comparable with the commercial product.
Respirable spray dried vancomycin coated magnetic nanoparticles for localized lung delivery
Moustafa M. Abdelaziz, Amr Hefnawy, Asem Anter, Menna M. Abdellatif, Mahmoud A.F. Khalil, et al.
International Journal of Pharmaceutics, 2022
Repurposing of atorvastatin emulsomes as a topical antifungal agent
Alaa S. Eita, Amna M. A. Makky, Asem Anter, Islam A. Khalil
Drug Delivery, 2022

RECENT SCHOLAR PUBLICATIONS

Coated Zein Polymeric Nanoparticles Loaded with Amlodipine as a Repurposed Antibacterial Ocular Cure for MRSA-Induced Infection: Optimization, In Vitro, Ex Vivo, and In Vivo …
AS Eita, AMA Makky, A Anter, IA Khalil
Pharmaceutics 17 (10), 1314 , 2025
2025
Citations: 1
Foamable pluroleosomes system loaded with amlodipine as a repurposed antibacterial topical formulation against MRSA-induced infection; optimization, in-vitro, ex-vivo, and in …
AS Eita, AMA Makky, A Anter, IA Khalil
International Journal of Pharmaceutics: X, 100406 , 2025
2025
Citations: 2
Anticariogenic efficacy of Indian Costus mouthwash in children
G Salem, M ElMansy, E Allam, A Anter, R Abdelmonem, M Rashed
Journal of Herbal Medicine 50, 100997 , 2025
2025
Citations: 3
The role of salicylic acid in increasing the Productivity of some wheat cultivars under saline soil conditions at South Sinai
MA Abdelaziz, A Anter
Journal of Plant Production 14 (9), 443-452 , 2023
2023
Citations: 3
Corneal targeted Amorolfine HCl-mixed micelles for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments
EM Abd-Elmonem, AMA Makky, A Antar, WH Abd-Elsalam, IA Khalil
Journal of Drug Delivery Science and Technology 85, 104614 , 2023
2023
Citations: 10
Inhalable vancomycin-loaded lactose microparticles for treatment of MRSA pneumonia
MM Abdelaziz, A Hefnawy, A Anter, MM Abdellatif, MAF Khalil, IA Khalil
Journal of Drug Delivery Science and Technology 80, 104150 , 2023
2023
Citations: 9
Repurposing of atorvastatin emulsomes as a topical antifungal agent
AS Eita, A Ma Makky, A Anter, IA Khalil
Drug Delivery 29 (1), 3414-3431 , 2022
2022
Citations: 31
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation
AS Eita, AMA Makky, A Anter, IA Khalil
International Journal of Pharmaceutics: X 4, 100140 , 2022
2022
Citations: 25
Silica-coated magnetic nanoparticles for vancomycin conjugation
MM Abdelaziz, A Hefnawy, A Anter, MM Abdellatif, MAF Khalil, IA Khalil
ACS omega 7 (34), 30161-30170 , 2022
2022
Citations: 30
Nanoparticles loaded thermoresponsive in situ gel for ocular antibiotic delivery against bacterial keratitis
MN Abbas, SA Khan, SK Sadozai, IA Khalil, A Anter, ME Fouly, AH Osman, ...
Polymers 14 (6), 1135 , 2022
2022
Citations: 57
Respirable spray dried vancomycin coated magnetic nanoparticles for localized lung delivery
MM Abdelaziz, A Hefnawy, A Anter, MM Abdellatif, MAF Khalil, IA Khalil
International Journal of Pharmaceutics 611, 121318 , 2022
2022
Citations: 23
Nanoparticles Loaded Thermoresponsive In Situ Gel for Ocular Antibiotic Delivery against Bacterial Keratitis. Polymers 2022; 14: 1135
M Abbas, SA Khan, SK Sadozai, IA Khalil, A Anter, MA Fouly, AH Osman, ...
s Note: MDPI stays neu-tral with regard to jurisdictional claims in … , 2022
2022
Citations: 2
Antibacterial Effect Of A New Herbal Paste Used As An Intracanal Medication In Necrotic Primary Molars, A Randomized Control Trial
G Salem, R Abd-Elmonem, A Anter, M El-mansy
Journal of Pharmaceutical Negative Results, 2593-601 , 2022
2022
Citations: 1
POSSIBILITY OF USING ALPHA AMYLASE PRODUCED BY PSEUDOMONAS STUTZERI STRAIN ATCC 17588 AS DIGESTIVE ENZYME
AAAEA Mohamed Salah Azab, Mohamed Ali Abdel-Rahman, Said El-Sayed Desouky
Egypt. J. Biotechnology. 58 (Pharmaceutical Microbiology.), 157-17. , 2019
2019

MOST CITED SCHOLAR PUBLICATIONS

Nanoparticles loaded thermoresponsive in situ gel for ocular antibiotic delivery against bacterial keratitis
MN Abbas, SA Khan, SK Sadozai, IA Khalil, A Anter, ME Fouly, AH Osman, ...
Polymers 14 (6), 1135 , 2022
2022
Citations: 57
Repurposing of atorvastatin emulsomes as a topical antifungal agent
AS Eita, A Ma Makky, A Anter, IA Khalil
Drug Delivery 29 (1), 3414-3431 , 2022
2022
Citations: 31
Silica-coated magnetic nanoparticles for vancomycin conjugation
MM Abdelaziz, A Hefnawy, A Anter, MM Abdellatif, MAF Khalil, IA Khalil
ACS omega 7 (34), 30161-30170 , 2022
2022
Citations: 30
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation
AS Eita, AMA Makky, A Anter, IA Khalil
International Journal of Pharmaceutics: X 4, 100140 , 2022
2022
Citations: 25
Respirable spray dried vancomycin coated magnetic nanoparticles for localized lung delivery
MM Abdelaziz, A Hefnawy, A Anter, MM Abdellatif, MAF Khalil, IA Khalil
International Journal of Pharmaceutics 611, 121318 , 2022
2022
Citations: 23
Corneal targeted Amorolfine HCl-mixed micelles for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments
EM Abd-Elmonem, AMA Makky, A Antar, WH Abd-Elsalam, IA Khalil
Journal of Drug Delivery Science and Technology 85, 104614 , 2023
2023
Citations: 10
Inhalable vancomycin-loaded lactose microparticles for treatment of MRSA pneumonia
MM Abdelaziz, A Hefnawy, A Anter, MM Abdellatif, MAF Khalil, IA Khalil
Journal of Drug Delivery Science and Technology 80, 104150 , 2023
2023
Citations: 9
Anticariogenic efficacy of Indian Costus mouthwash in children
G Salem, M ElMansy, E Allam, A Anter, R Abdelmonem, M Rashed
Journal of Herbal Medicine 50, 100997 , 2025
2025
Citations: 3
The role of salicylic acid in increasing the Productivity of some wheat cultivars under saline soil conditions at South Sinai
MA Abdelaziz, A Anter
Journal of Plant Production 14 (9), 443-452 , 2023
2023
Citations: 3
Foamable pluroleosomes system loaded with amlodipine as a repurposed antibacterial topical formulation against MRSA-induced infection; optimization, in-vitro, ex-vivo, and in …
AS Eita, AMA Makky, A Anter, IA Khalil
International Journal of Pharmaceutics: X, 100406 , 2025
2025
Citations: 2
Nanoparticles Loaded Thermoresponsive In Situ Gel for Ocular Antibiotic Delivery against Bacterial Keratitis. Polymers 2022; 14: 1135
M Abbas, SA Khan, SK Sadozai, IA Khalil, A Anter, MA Fouly, AH Osman, ...
s Note: MDPI stays neu-tral with regard to jurisdictional claims in … , 2022
2022
Citations: 2
Coated Zein Polymeric Nanoparticles Loaded with Amlodipine as a Repurposed Antibacterial Ocular Cure for MRSA-Induced Infection: Optimization, In Vitro, Ex Vivo, and In Vivo …
AS Eita, AMA Makky, A Anter, IA Khalil
Pharmaceutics 17 (10), 1314 , 2025
2025
Citations: 1
Antibacterial Effect Of A New Herbal Paste Used As An Intracanal Medication In Necrotic Primary Molars, A Randomized Control Trial
G Salem, R Abd-Elmonem, A Anter, M El-mansy
Journal of Pharmaceutical Negative Results, 2593-601 , 2022
2022
Citations: 1
POSSIBILITY OF USING ALPHA AMYLASE PRODUCED BY PSEUDOMONAS STUTZERI STRAIN ATCC 17588 AS DIGESTIVE ENZYME
AAAEA Mohamed Salah Azab, Mohamed Ali Abdel-Rahman, Said El-Sayed Desouky
Egypt. J. Biotechnology. 58 (Pharmaceutical Microbiology.), 157-17. , 2019
2019

assem antar abdelalim mohamed

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS