Dr Nurul Akmal Jamaludin

Abu-Hayyeh S, Papacleovoulou G, Lövgren-Sandblom A, Tahir M, Oduwole O, Jamaludin NA, Ravat S, Nikolova V, Chambers J, Selden C, Rees M, Marschall HU, Parker MG, Williamson C. Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype. Hepatology. 2013 Feb;57(2):716-26. doi: 10.1002/. Epub 2013 Jan 8
Cited by: 104
Jamaludin NA, Basatvat S, Aboussahoud W, Elliott S, Hunt S, Peacock B, Ebbens S, Fazeli F. Characterisation of extracellular vesicles produced by the Porcine oviductal epithelial cells using size exclusion chromatography. Society for Reproduction and fertility Annual Conference 2016, Winchester, UK, 11-13 July 2016.
Jamaludin NA, Meikle A, Hunt S, Wachernig H, Thurston LM, Andronowska A,Ebbens S, Fazeli A. Characterisation of extracellular vesicles secreted byoviductal and endometrial epithelial cells. UKEV 2016 congress, Oxford Brookes University, UK.

EDUCATION

UNIVERSITY OF SHEFFIELD [June 2013 until May 2018]
PhD
IMPERIAL COLLEGE LONDON [October 2008 until October 2009]
MSc in Reproductive and Developmental Biology

RESEARCH INTERESTS

Role of extracellular vesicles in reproductive medicine.

Scopus Publications

TOWARDS SUSTAINABLE COMMUNITY: SOCIAL RESPONSIBILITY AND COMMUNITY RESILIENCE IN FLOOD DISASTER MANAGEMENT
Malaysian Journal of Public Health Medicine, 2024
Immune-Cell-Mediated Cancer Treatment: Advantages, Drawbacks And Future Direction
Ohn Mar Lwin, Atif Amin Baig, Nurul Akmal Jamaludin, Thin Thin Aung, Haziq Hazman Norman, Aung Myo Oo
Journal of Experimental Biology and Agricultural Sciences, 2023
Cancer ranks as the most lethal and prevalent non-communicable disease in clinical settings. Therapeutic options for cancer comprise chemotherapy, radiotherapy, surgery, and combined treatment. Cancer remission and relapse cases are widespread despite having various advanced medications and sophisticated dissection techniques. A new approach involving immune-cell-mediated cancer therapy has been adopted extensively for cancer treatments by utilizing immune cells. Immunotherapy has gained much attention to prevent and treat various types of cancer. Immunotherapy treatments operate in multiple contexts. Several immunotherapy therapeutic interventions assist the immune function in halting or reducing the advancement of cancer cells. Many also facilitate the immune cells in destroying cancerous cells or safeguarding against cancer from disseminating to certain other regions of the human body. Among other methods, genetic manipulation of immune cells offers hope for innovative anticancer treatment. T lymphocytes and natural killer cells have become the most extensively documented immune cells for immunotherapy. Chimeric antigen receptor T-cell therapy exhibits the most promising blood cancer treatment. However, adoptive NK cell transfer therapy displays potential anticancer treatment options, although more research is needed to be carried out. In addition, cytokine-induced immunomodulation is also plausible for cancer immunotherapy. This review will highlight the most comprehensive information, observations, and consequences associated with different cancer immunotherapy initiatives.
Trends in Health Communication: Social Media Needs and Quality of Life among Older Adults in Malaysia
Hana W. Jun Chen, Roy Rillera Marzo, Nur Hafizah Sapa, Absar Ahmad, Haryati Anuar, Mohammed Faez Baobaid, Nurul Akmal Jamaludin, Hazian Hamzah, Siamak Sarrafan, Hassan Omar Ads, Kavitha Ashok Kumar, Jalal Hadi, Hafsah Sazali, Mohammed A. Abdalqader
Healthcare Switzerland, 2023
Background: While social media continues to dominate, social media platforms have become powerful health communication tools for older users. However, fulfilling their social media needs can be both detrimental and beneficial to their quality of life (QoL). This study assessed social media needs as they relate to QoL among older adults in Malaysia. Methods: We conducted a cross-sectional study and adopted convenience sampling to recruit participants. The participants were required to self-report their sociodemographic profile, social media use and needs, and QoL. Social media use and needs were assessed using the Social Networking Sites Uses and Needs (SNSUN) scale, and QoL was assessed using the WHOQOL-BREF questionnaire. Multiple linear regression was performed to identify the predictors of QoL. Results: The findings revealed that the fulfilment of social integrative needs was the strongest predictor of higher QoL in all domains. However, those using social media for their affective needs demonstrated lower psychological health quality. Conclusions: Fulfilling social integrative needs is the key to improving the QoL among older adults. The continuous development of age-friendly applications is essential to keep up with constantly changing social media trends and bridge the gap of social media inequalities. More importantly, it would enable older adults to utilize social media to its fullest potential and enjoy a higher QoL through accessible health communication tools.
Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin
Nurul Akmal Jamaludin, Lisa Marie Thurston, Krzysztof Jan Witek, Albany Meikle, Shaghayegh Basatvat, Sarah Elliott, Stuart Hunt, Aneta Andronowska, Alireza Fazeli
Theriogenology, 2019
Effective communication between the maternal reproductive tract, gametes and the pre-implantation embryo is essential for the successful establishment of pregnancy. Recent studies have recognised extracellular vesicles (EVs) as potent vehicles for intercellular communication, potentially via their transport of microRNAs (miRNAs). The aim of the current investigation was to determine the size, concentration and electrical surface properties (zeta potential) of EVs secreted by; (1) primary cultures of porcine oviductal epithelial cells (POECs) from the isthmus and ampullary regions of the female reproductive tract; (2) Ishikawa and RL95-2 human endometrial epithelial cell line cultures; and (3) the non-reproductive epithelial cell line HEK293T. In addition, this study investigated whether EVs secreted by POECs contained miRNAs. All cell types were cultured in EV-depleted medium for 24 or 48 h. EVs were successfully isolated from conditioned culture media using size exclusion chromatography. Nanoparticle tracking analysis (NTA) was performed to evaluate EV size, concentration and zeta potential. QRT-PCR was performed to quantify the expression of candidate miRNAs (miR-103, let-7a, miR-19a, miR-203, miR-126, miR-19b, RNU44, miR-92, miR-196a, miR-326 and miR-23a). NTA confirmed the presence of EVs with diameters of 50–150 nm in all cell types. EV size distribution was significantly different between cell types after 24 and 48 h of cell culture and the concentration of EVs secreted by POECs and Ishikawa cells was also time dependent. The distribution of EVs with specific electrokinetic potential measurements varied between cell types, indicating that EVs of differing cellular origin have varied membrane components. In addition, EVs secreted by POECs exhibited significantly different time dependant changes in zeta potential. QRT-PCR confirmed the presence of miR-103, let-7a, miR-19a, miR-203, miR-126, and miR-19b in EVs secreted by POECs (CT ≥ 29). Bioinformatics analysis suggests that these miRNAs are involved in cell proliferation, innate immune responses, apoptosis and cellular migration. In conclusion, reproductive epithelial cells secrete distinct populations of EVs containing miRNAs, which potentially act in intercellular communication in order to modulate the periconception events leading to successful establishment of pregnancy.
Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype
Shadi Abu‐Hayyeh, Georgia Papacleovoulou, Anita Lövgren‐Sandblom, Mehreen Tahir, Olayiwola Oduwole, Nurul Akmal Jamaludin, Sabiha Ravat, Vanya Nikolova, Jenny Chambers, Clare Selden, Myrddin Rees, Hanns‐Ulrich Marschall, Malcolm G. Parker, Catherine Williamson
Hepatology, 2013
Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy‐specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death. The endocrine signals that cause cholestasis are not known but 3α‐sulfated progesterone metabolites have been shown to be elevated in ICP, leading us to study the impact of sulfated progesterone metabolites on farnesoid X receptor (FXR)‐mediated bile acid homeostasis pathways. Here we report that the 3β‐sulfated progesterone metabolite epiallopregnanolone sulfate is supraphysiologically raised in the serum of ICP patients. Mice challenged with cholic acid developed hypercholanemia and a hepatic gene expression profile indicative of FXR activation. However, coadministration of epiallopregnanolone sulfate with cholic acid exacerbated the hypercholanemia and resulted in aberrant gene expression profiles for hepatic bile acid‐responsive genes consistent with cholestasis. We demonstrate that levels of epiallopregnanolone sulfate found in ICP can function as a partial agonist for FXR, resulting in the aberrant expression of bile acid homeostasis genes in hepatoma cell lines and primary human hepatocytes. Furthermore, epiallopregnanolone sulfate inhibition of FXR results in reduced FXR‐mediated bile acid efflux and secreted FGF19. Using cofactor recruitment assays, we show that epiallopregnanolone sulfate competitively inhibits bile acid‐mediated recruitment of cofactor motifs to the FXR‐ligand binding domain. Conclusion: Our results reveal a novel molecular interaction between ICP‐associated levels of the 3β‐sulfated progesterone metabolite epiallopregnanolone sulfate and FXR that couples the endocrine component of pregnancy in ICP to abnormal bile acid homeostasis. (HEPATOLOGY 2013;)

RECENT SCHOLAR PUBLICATIONS

Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin
NA Jamaludin, LM Thurston, KJ Witek, A Meikle, S Basatvat, S Elliott, ...
Theriogenology 135, 121-137 , 2019
2019
Citations: 32
Extracellular vesicles mediated intercellular communication between spermatozoa and oviduct: A new paradigm of spermatozoa–oviduct cross talk
NA Jamaludin
University of Sheffield , 2018
2018
Characterisation of extracellular vesicles produced by the Porcine oviductal epithelial cells using size exclusion chromatography
NA Jamaludin, S Basatvat, W Aboussahoud, S Elliott, S Hunt, B Peacock, ...
Reproduction Abstracts 3 , 2016
2016
Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype
S Abu-Hayyeh, G Papacleovoulou, A Lövgren-Sandblom, M Tahir, ...
Hepatology 57 (2), 716-726 , 2013
2013
Citations: 243

MOST CITED SCHOLAR PUBLICATIONS

Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype
S Abu-Hayyeh, G Papacleovoulou, A Lövgren-Sandblom, M Tahir, ...
Hepatology 57 (2), 716-726 , 2013
2013
Citations: 243
Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin
NA Jamaludin, LM Thurston, KJ Witek, A Meikle, S Basatvat, S Elliott, ...
Theriogenology 135, 121-137 , 2019
2019
Citations: 32
Extracellular vesicles mediated intercellular communication between spermatozoa and oviduct: A new paradigm of spermatozoa–oviduct cross talk
NA Jamaludin
University of Sheffield , 2018
2018
Characterisation of extracellular vesicles produced by the Porcine oviductal epithelial cells using size exclusion chromatography
NA Jamaludin, S Basatvat, W Aboussahoud, S Elliott, S Hunt, B Peacock, ...
Reproduction Abstracts 3 , 2016
2016